Could avoiding Pre-Radiation tooth removal protect jaw health?

NCT ID NCT07764887

Not yet recruiting Disease control Sponsor: First Affiliated Hospital of Guangxi Medical University Source: ClinicalTrials.gov ↗

First seen Aug 14, 2026 · Last updated Aug 14, 2026

Summary

This trial asks whether it is safe to skip the routine removal of impacted teeth before radiation therapy for nasopharyngeal carcinoma. Half of the participants will have the extraction as usual, while the other half will not. The study will compare the risk of jaw bone damage (osteoradionecrosis) over two years, along with survival and quality of life, to see if omitting the procedure is a viable option.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Omission of prophylactic impacted tooth extraction before radiotherapy
What this could lead to: If skipping the extraction is safe, patients could avoid an unnecessary dental procedure before cancer treatment, reducing discomfort and delays.
What could go wrong: The trial is early and noninferiority design; if omission increases jaw bone damage risk, it would be unsafe. Results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

nasopharyngeal carcinoma osteoradionecrosis osteoradionecrosis of the mandible Tooth, Impacted

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NASOPHARYNGEAL CARCINOMA (NPC) OSTEORADIONECROSIS OF THE JAW

Contacts and locations

Locations

Affiliated Hospital of Youjiang Medical University for Nationalities

Baise City, Guangxi, 533000, China
Beihai People's Hospital

Beihai, Guangxi, 536000, China
Guigang People's Hospital

Guigang, Guangxi, 537100, China
Liuzhou People's Hospital

Liuzhou, Guangxi, 545006, China
Liuzhou Workers' Hospital

Liuzhou, Guangxi, 545007, China
The Affiliated Hospital of Guilin Medical University

Guilin, Guangxi, 541001, China
The First Affiliated Hospital of Guangxi Medical University

Nanning, Guangxi, 530021, China
The First People's Hospital of Yulin

Yulin, Guangxi, 537000, China
The People's Hospital of Guangxi Zhuang Autonomous Region

Nanning, Guangxi, 530000, China
Wuming Hospital Affiliated to Guangxi Medical University

Nanning, Guangxi, 530199, China
Wuzhou Red Cross Hospital

Wuzhou, Guangxi, 543002, China

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