Simple foot exercise may ease stubborn knee pain in women

NCT ID NCT07703072

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First seen Jul 14, 2026 · Last updated Jul 15, 2026 · Updated 1 time

Summary

This study tests whether adding short foot exercises—which train the small muscles in the foot—to standard hip and knee strengthening can better relieve pain and improve function in women with patellofemoral pain syndrome (PFPS). Thirty-eight women aged 18 to 45 with PFPS will be randomly assigned to either a combined exercise group or a group doing only hip and knee exercises for six weeks. The goal is to see if the foot-focused approach leads to greater reductions in pain and better knee function.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Short foot exercises combined with hip and knee strengthening exercises
What this could lead to
If effective, this combined exercise approach could offer a simple, non-drug way to reduce knee pain and improve daily function in women with patellofemoral pain syndrome.
What could go wrong
This is a small, early-stage trial with only 38 participants, so results may not apply broadly. Exercise adherence and individual differences could affect outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 38 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jul 2026

An estimate. Start dates often move.

Expected to finish

Nov 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 45 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Diagnosed cases of patellofemoral pain syndrome confirmed by this protocol. 1. Females aged 18-45 years 2. Anterior or retro patellar knee pain lasting ≥ 6 weeks 3. Pain provoked by at least one PFJ-loading task, including: 1. squatting, 2. stair climbing/descending, 3. running, 4. prolonged sitting with knees flexed 4. Pain elicited by at least two of four clinical tests; 1. Pain during isometric quadriceps contraction at 20-30° knee flexion 2. Pain on palpation of the patellofemoral joint line 3. Pain during patellar compression 4. Pain during active resisted knee extension Exclusion Criteria: History of patellar instability, including subluxation or dislocation 2. Evidence of tibiofemoral pathology, such as: Ligamentous injuries, meniscal tears, and symptomatic knee effusion. 3\. Previous knee surgery within the last 12 months 4. Radiographic or clinical knee osteoarthritis. 5. Neurological disorders or systemic inflammatory diseases that may influence gait or pain perception. \-

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

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How to take part

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Contacts and locations

Locations

  • NUR FMH System

    Lahore, Punjab Province, 54000, Pakistan

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