Depressive disorder

This study tests whether deep brain stimulation (DBS) can help people with severe depression that hasn't improved with other treatments. Participants have a device surgically implanted to stimulate a specific brain area, then receive active stimulation for six months along with b…

This study tested whether levodopa, a drug used for Parkinson's disease, can improve thinking speed, walking, and mood in older adults with depression. Researchers gave 79 participants either levodopa or a placebo for three weeks. The goal was to see if boosting dopamine could he…

This study tests whether a computer-assisted tool helps mental health providers in rural VA clinics deliver cognitive behavioral therapy (CBT) more effectively for depression and anxiety. About 34 therapists and 167 veterans will take part. Therapists are randomly assigned to use…

This study tests whether a personalized mobile health app (iTAB-CV) plus self-monitoring helps people with bipolar disorder or major depression take their blood pressure medication more regularly and lower their blood pressure. About 176 adults aged 21-80 with both conditions and…

This study tests a new behavioral therapy called OPT-A for teenagers who have both substance use problems and mood or anxiety disorders. 140 teens aged 10-17 will receive either OPT-A or standard treatment. Researchers will track substance use and mental health for 18 months to s…

This trial investigates whether adding low-intensity transcranial magnetic stimulation (Li-TMS) to standard antidepressant medication can improve depressive symptoms and sleep disorders in people with major depression. The study involves 40 participants who receive either real Li…

This study tested a weight-loss program called CoachToFit for 257 veterans with serious mental illness (like schizophrenia or bipolar disorder) who were obese. Participants used a smartphone app, an activity tracker, and a Bluetooth scale, and worked with a peer coach. The goal w…

This study tested a stepped care model for depression in 14 HIV clinics in Malawi. 487 adults with moderate to severe depression received group counseling and, if needed, antidepressant medication. The goal was to see if this approach could reduce depression symptoms and improve …

This completed trial in Xishui, China, tested a community-based program for 3,571 adults aged 35 and older who were at high risk for COPD and had mental health symptoms. The program included lung function tests, digital mental health support, smoking cessation help, and health ed…

This study tested a stepped-care program where trained non-specialists provided mental health support and HIV medication adherence help to 280 people in rural Zimbabwe. Participants had both depression and high HIV viral loads. The goal was to see if this approach could improve v…

This study tested a behavioral activation program given as part of a freshman orientation course at the University of Kansas. The program helps students set personal goals and engage in rewarding activities to indirectly reduce alcohol misuse, stress, binge eating, and depression…

This study tested a special team-based program called R-FACT for people with serious mental illness who are also involved with the criminal justice system. The program provides intensive, community-based support with close coordination between mental health and justice staff. Res…

This study tested magnetic seizure therapy (MST) in 239 adults with treatment-resistant depression to see if it works as well as electroconvulsive therapy (ECT) but with fewer memory side effects. MST uses magnetic pulses to trigger a controlled seizure, aiming to relieve depress…

This study looked at whether adding lithium to personalized maintenance ECT can help prevent depression relapse in people who already got better with ECT. 96 adults with major depression took part. The goal was to see if the combination keeps depression away longer than ECT alone…

This study tested whether an online screening tool (mISP) alone or combined with a mental health skills program (MINDBODYSTRONG) can reduce suicide risk and depression in nurses. About 849 nurses who were at moderate to high risk for suicide took part. The program teaches coping …

This study looked at 6 people with schizophrenia who were already taking a combination of two long-acting injectable medications: Abilify Maintena and Rexulti. Researchers tracked their symptoms and side effects over 6 months to see how well the combo worked in everyday life. The…

This study tested a blended collaborative care model that uses telemedicine to integrate mental health treatment into primary care at smaller VA clinics serving rural veterans. Researchers enrolled 318 veterans who screened positive for depression, alcohol use disorder, or PTSD. …

This study tested whether deep brain stimulation (DBS) can help people with severe depression that hasn't responded to other treatments. 46 patients received either active DBS or a sham (inactive) device. The goal was to see if DBS reduces depression symptoms safely.

This study tested whether a 3-year physical activity program could help prevent colon cancer from coming back in 889 patients who had surgery and chemotherapy for high-risk stage II or stage III colon cancer. Participants were randomly assigned to either the exercise program plus…

This study tested a program called Positive Minds-Strong Bodies Enhanced (PMSB-E) in 427 older adults from racial, ethnic, and linguistic minority groups who had depression, anxiety, and some mobility issues. The program combined mental health support with physical exercises to h…

This study looked at whether providing mental health care to people who inject drugs can improve their mental health and reduce their risk of getting HIV or hepatitis C. Over 500 participants in Haiphong, Vietnam, received free psychiatric consultations, medications, and support …

This completed trial tested a mobile app called iGAME that gives tips to reduce sitting and encourage healthy habits. Researchers enrolled 48 adults with low back pain, cancer, or depression who were sedentary. The goal was to see if the app could increase physical activity and i…

This study tested two ways to help primary care doctors prescribe opioids more safely for patients with chronic pain, depression, or anxiety. One approach used an electronic tool that reminded doctors about risk checks and guidelines. The other added a team of a pharmacist, a soc…

This study tested a collaborative care model for people with opioid use disorder and depression, anxiety, or PTSD. 567 adults received medication (buprenorphine-naloxone or naltrexone) along with therapy and support from a primary care team. The goal was to reduce opioid use and …

This study tested whether a 6-week mindfulness program could help teens at risk for type 2 diabetes by reducing depression and insulin resistance. 120 teens aged 12-17 with overweight, a family history of diabetes, and elevated depression symptoms took part. They were randomly as…

This study looked at the long-term safety of a new daily medication called BHV-7000 for people with major depressive disorder. A total of 233 adults who had already completed an earlier study took the pill once a day. Researchers tracked side effects, lab results, and heart chang…

This study tested a 12-month telephone-based nurse care program for 805 adults with depression and signs of opioid use disorder. Participants were randomly assigned to receive nurse support or usual care. The goal was to see if the program could improve treatment for opioid use a…

This study tested a personalized brain stimulation technique called accelerated intermittent theta burst stimulation (aiTBS) in 79 people with treatment-resistant depression. The goal was to see if targeting specific brain areas could ease symptoms like loss of pleasure (anhedoni…

This study looked at whether repeated ketamine infusions can help people with hard-to-treat bipolar depression stay well. 41 adults who had already responded to an initial course of ketamine received up to 6 more infusions over 12 weeks. The goal was to see if maintenance doses c…

This study tested whether a smartphone app designed for people with serious mental illness can help them quit smoking better than standard methods. Researchers enrolled 343 adults with conditions like bipolar disorder or schizophrenia who wanted to quit. Participants used either …

This completed study tested whether painting metal roofs with a special heat-reflecting coating can lower indoor temperatures and improve health in Niue, a Pacific island nation facing record heat. Researchers enrolled 288 adults living in single-story homes with metal roofs. The…

This study tested if transplanting healthy gut bacteria (fecal microbiota) can help people with chronic insomnia. 80 adults received either the bacteria or a placebo in capsules. Researchers measured sleep quality using sleep tests and questionnaires to see if the treatment impro…

This completed study tested a health system intervention called ENHANCE in 1,837 adults aged 40+ with at least two chronic conditions (HIV, high blood pressure, diabetes, asthma, or depression). The intervention included a clinical decision support tool for clinicians, health edu…

This study tested whether a program called Circadian Reinforcement Therapy (CRT) — which helps people strengthen their sleep-wake cycle and daily routines — could reduce the chance of depression coming back after leaving a psychiatric hospital. 103 adults with major depression us…

This study tested whether adding mental health care (like therapy and education) to standard job support helps people on sick leave due to anxiety or depression return to work sooner. Over 600 participants in Denmark were randomly assigned to one of two programs or usual care. Th…

This study tested whether a daily probiotic drink (like Yakult) can reduce cold symptoms in triathletes before and after a competition. 80 healthy amateur triathletes drank either the probiotic or a placebo for 30 days before and 14 days after a race. Researchers tracked symptoms…

This study tested whether adding peer support and online education helps college students manage their weight and improve their mood. Researchers enrolled 216 full-time students aged 18-25 with a BMI of 24 or higher and randomly assigned them to one of three groups: standard heal…

This early-stage trial tested whether a one-time infusion of donor stem cells is safe for people with both alcohol use disorder and major depression. Thirty-one participants received either the stem cells or a placebo. The main goal was to check for serious side effects, like sui…

This study tested whether delivering coordinated specialty care (CSC) via telehealth works as well as standard in-person care for young people (ages 16–35) with early psychosis. Over 12 months, researchers tracked hospitalizations and engagement in 74 participants. The goal was t…

This study tested whether a speech analysis platform called AcceXible can accurately screen for depression and anxiety in university students. Over 900 students aged 16-25 provided voice samples through open-ended speaking tasks. The platform analyzed acoustic and linguistic feat…

This study tested a smartphone app that analyzes speech to screen for depression and anxiety in 785 university students aged 16-25. Participants completed speaking tasks, and the app's accuracy was compared to standard mental health questionnaires. The goal is to provide a quick,…

This study tested whether a speech analysis tool called acceXible can help screen for and monitor major depressive disorder. Researchers analyzed voice recordings from 166 adults as they described images. The goal was to see if changes in speech patterns relate to depression. If …

This study tested whether an electronic self-report screening system (eScreening) helps VA clinics detect depression, PTSD, alcohol problems, and suicide risk more quickly and more often in newly enrolled post-9/11 veterans. Researchers compared screening rates and referral times…

This study tested whether personalized, intensive nursing follow-up (by phone, home visits, or hospital consultations) after a suicide attempt could prevent another attempt or crisis in people with mood disorders. 380 participants were followed for one year. The goal was to see i…

This study tests a program called 'Thoughts and Health' designed to prevent depression in adolescents. The program is delivered in 12 sessions in a school setting. Researchers will see if it helps students' mental health and their ability to finish junior high with passing grades…

This study follows up on 217 children who took part in a cognitive behavioral therapy program for anxiety and depression 5 years earlier. Researchers want to see if the program helped prevent these conditions from developing or worsening over time. The children, now teenagers, wi…

This study tested an online program called PROCARE-I+ designed to prevent anxiety and depression in teenagers who are at high risk. Thirty adolescents with early symptoms took part in the program, which included extra modules tailored to their needs. Results showed improvements i…

This study tested an online psychological program designed to prevent depression in people with atrial fibrillation (AF), a common heart rhythm problem. The program combined phone or video sessions with online modules and exercises over 4-12 weeks. The trial included 28 adults wi…

This study tested a program called iDOVE2 for teens at risk of peer violence and mild-to-moderate depression. The program started with a brief session in the emergency department, followed by automated text messages designed to prevent violence and depressive symptoms. Researcher…

This study looked at how to keep a program called ROSE, which prevents postpartum depression, running in clinics that serve low-income pregnant women. Researchers tested different levels of support—like coaching—to see what clinics need to keep offering the program long-term. The…

This study tested whether telehealth coaching from a nurse, based on cognitive behavioral therapy for insomnia (pCBT-I), could prevent or reduce insomnia and depression in 167 adults with low income or education. Participants had early signs of insomnia and were coached to improv…

This study tested whether an 8-week program focused on boosting positive emotions could improve how children of mothers with depression process rewards. 73 children aged 8-12 and their mothers participated. The program used cognitive and behavioral skills to up-regulate positive …

This study tested a program called "Parents and Babies" to see if it could prevent depression in pregnant women. The program is an online course with phone support. 510 pregnant women with mild to moderate depression symptoms took part. The goal was to see if the course plus phon…

This study tested whether giving a low-dose ketamine drip after surgery could prevent depressive symptoms in 32 neurosurgical patients who had a history of depression. Researchers measured depression scores before surgery and for two weeks after. The main goal was to see if a lar…

This completed study tested whether a smartphone app called InBloom could help prevent postpartum depression in pregnant people at risk. 152 participants were randomly assigned to use the app or attend a weekly group program called ROSE. The study measured depression rates and se…

This study tested an online parenting program called Family Check-Up Online for rural families where a parent may misuse opioids. 356 parents of young children (18 months to 5 years) took part. The program aimed to improve parenting skills, reduce stress and depression, and preve…

This study tested whether a 12-week healthy lifestyle program could prevent depression in older adults who recently lost a spouse. Participants used digital tools to track sleep, meals, and activity, plus received weekly health coaching. The goal was to see if this approach reduc…

This study tested whether a single 3-hour group therapy session based on Acceptance and Commitment Therapy (ACT) could prevent mental health disorders in 120 women recently displaced by war in Ukraine. The women had mild to moderate symptoms of anxiety or depression. The goal was…

This study tested a trauma-informed program to prevent postpartum depression in women living in earthquake-affected regions of Türkiye. The program included education, emotional support, and coping skills, delivered by healthcare workers. 106 women took part, and the study measur…

This study tested a 10-week program called the Protecting Families Program (PFP) for depressed parents and their pre-teen children. The goal was to see if the program could prevent depression in the children. 42 families took part, with parents in treatment for depression. The pr…

This study tested a behavioral sleep program for 16 depressed teenagers who slept less than 7 hours on school nights or had irregular sleep schedules. The program included one session with a provider and used smartphone tools to help teens create a plan for longer and more regula…

This study tests whether shining a specific type of near-infrared light on the front of the brain can safely help people with major depressive disorder. The light is thought to boost energy production in brain cells, which may improve mood. Researchers will measure changes in dep…

This study tests whether a non-invasive brain stimulation device, used at home, can safely and effectively ease symptoms of major depression in people who have not improved with medication. Participants use the device for 30 minutes a day, five days a week, for four weeks. The tr…

This study tests whether a mindfulness app called Headspace can help low-income parents reduce stress, anxiety, and depression. Participants use the app on their own schedule for guided meditations. Researchers measure changes in stress and mood over time to see if the app provid…

This study explores whether virtual reality goggles and noise-cancelling headphones can make ketamine/esketamine treatment for depression more tolerable and effective. Participants receive a single treatment while immersed in a relaxing virtual environment. The goal is to see if …

This study tests whether adding passive sensing technology (like smartphone data) to a standard counseling program helps community health workers better treat postpartum depression in low-resource settings. The trial compares the digital-enhanced approach to standard counseling a…

This trial tests whether a brief online group therapy called EMDR Flash can help adults who survived the 2023 Kahramanmaraş earthquakes in Türkiye. Participants receive two 60-90 minute group sessions via Zoom and are compared to a waitlist group. The study measures changes in PT…

This study tested a counseling program called Youth Friendship Bench SA for young women aged 18-25 in South Africa who had symptoms of depression, anxiety, or stress. The program included individual and group counseling sessions, plus optional text reminders. The goal was to see …

This pilot study tested a six-session culturally adapted cognitive behavioral therapy (Ca-CBT) for depression and anxiety in 50 people living with HIV in Pakistan. The therapy was delivered by trained HIV health workers and included culturally relevant stories and materials. The …

This study tested a new capsule called MI078 in 72 women with postpartum depression. The women took the drug or a placebo for 3 days. Researchers measured depression scores to see if the drug helps symptoms and to find the best dose. The trial is complete, and results will show i…

This study tested whether adding dog-assisted therapy to usual care helps teens aged 12-18 with mental health issues like anxiety, depression, and emotional dysregulation. 70 teens in a day hospital were randomly assigned to either get dog therapy plus usual care or usual care al…

This study tested an experimental drug called CLE-100 (oral esketamine) in 99 adults with major depression that didn't get better after trying at least two standard antidepressants. Participants took CLE-100 or a placebo pill alongside their usual antidepressant for several weeks…

This pilot study tested whether a non-invasive device that uses magnetic pulses to stimulate the brain (rTMS) could safely help cancer survivors with depression and anxiety. Twenty-four adults who had been treated for any type of cancer and still had major depression received eit…

This study tested whether daily gummies containing L-theanine and lion's mane mushroom extract could reduce stress, anxiety, and improve sleep in university students. 67 students aged 18-25 took either the gummies or no supplement for 8 weeks. The goal was to see if this natural …

This study compared two psychological treatments—cognitive behavioral therapy (CBT) and Ericksonian hypnosis—for reducing symptoms of depression and anxiety. 45 adults with symptoms but no formal diagnosis were randomly assigned to CBT, hypnosis, or a no-treatment control group. …

This study looked at whether having a tendency toward depression affects how well people with thymoma-associated myasthenia gravis (MG) respond to psychological counseling. Nineteen adults who had surgery for thymoma and MG received eight sessions of counseling based on Gestalt t…

This small study tested whether a type of brain stimulation called iTBS could help people who have both hoarding disorder and depression. Fourteen adults received 20 sessions over 4 weeks. Researchers measured changes in hoarding and depression symptoms, as well as brain connecti…

This study compared an online yoga program with an online behavioral therapy for adults with depression. Over 500 participants were randomly assigned to either yoga or therapy for 12 weeks. Researchers measured depression symptoms and well-being at several points to see which app…

This study looked at whether adding supervised Pilates exercises and structured prenatal education to standard care could reduce depressive symptoms, low back pain, and labor pain in first-time mothers. 85 pregnant women participated, with some attending the program and others re…

This study tested whether giving oral probiotics to adolescents before non-cardiac, non-digestive surgeries could reduce anxiety and depression afterward. 150 teens aged 12-17 were randomly assigned to receive either probiotics or a placebo. Researchers measured anxiety and depre…

This study tested a mobile app called EASE to help people manage anxiety and depression during the COVID-19 pandemic. It included 822 adults who identified as Black, Hispanic, or American Indian and had significant anxiety or depression symptoms. The app provided symptom tracking…

This study tested whether professional socio-aesthetics (specialized beauty and well-being care) can improve quality of life, reduce pain, and ease anxiety in adults undergoing chemotherapy for lung, breast, colon, or prostate cancer. 400 participants were randomly assigned to re…

This study tested whether listening to Baroque music for 30 minutes could reduce anxiety in 18 adults with major depressive disorder. Participants listened to a specially chosen set of Baroque pieces, and their anxiety levels were measured before and after. The idea is that the m…

This study tested a program called PRIME for older women with chronic pain and depression who also have physical disabilities. Nine women took part in nurse-led goal-setting visits and group therapy sessions focused on acceptance and commitment. The goal was to see if this combin…

This study tested a virtual support group called the Sister Circle for Black women aged 40 and older who have depressive symptoms. The program ran for 8 weeks and aimed to see if it was feasible and acceptable. Thirty women participated, and researchers measured how many complete…

This study tested a smartphone app that uses cognitive behavioral therapy (CBT) to help treat depression. 146 adults with depression used the app for 8 weeks, completing weekly AI-guided lessons and homework. The goal was to see if the app could reduce depression symptoms, as mea…

This study tested an accelerated form of transcranial magnetic stimulation (TMS) in 50 adults with treatment-resistant depression. Participants received 50 sessions over two weeks, comparing a bilateral approach (stimulating both sides of the brain) with a unilateral one (stimula…

This study tested three short, one-time digital sessions (called Project YES) designed to help teens and young adults ages 13-25 who have depression, anxiety, or eating disorder symptoms. Participants completed questionnaires before the session, right after, and again 3 months la…

This study tested an online guided self-help program called EMPOWER for medical professionals with mild depression or anxiety. The program teaches problem-solving and acceptance skills through videos and stories. 161 participants were randomly assigned to the program or a control…

This study tested whether wearing special light glasses for 30 minutes each morning could help breast cancer patients feel less tired, sleep better, and think more clearly during treatment. The trial included 260 women with early-stage breast cancer, plus a healthy comparison gro…

This study tested a type of group therapy called Resilience-Oriented Therapy (RoT) for adults in Rwanda who were struggling with mental health issues like trauma, depression, anxiety, or anger. 427 people took part, and the therapy was tailored to each person's main problem, such…

This study tested a 6-week mindful self-compassion program for homeless women with PTSD and substance use. The program includes meditation, group discussions, and home practices. Researchers compared the program to usual care in 202 women living in a residential drug treatment fa…

This study tested whether internet-delivered cognitive behavior therapy (ICBT) can help teens aged 13-17 with mild to moderate depression. 219 participants were randomly assigned to guided ICBT (with therapist support), self-guided ICBT (without support), or usual care. The goal …

This study tested an online group program called Healthy Minds for people on sick leave due to depression, anxiety, or adjustment disorders. 123 participants either joined the 8-week program or received standard care. Researchers tracked their return to work, symptoms, and job fu…

This study tested an 8-week program called STAIRS for people recovering from depression. The program combines group meetings with homework exercises to help improve personal recovery and daily functioning. 36 adults in the final phase of depression treatment took part. The goal w…

This study tested whether a gentle electrical current applied to the scalp (tDCS) could make computer-based brain training more effective for older adults with recurrent depression. Sixteen people aged 60 and older took part. The goal was to see if this combination improved memor…

This study tested a brief, community-based psychological program called Problem Management Plus to see if it can reduce depression, anxiety, and distress. Over 1,200 adults with mild to moderate symptoms took part. The program focuses on practical problem-solving skills in just f…

This study tested whether an AI chatbot called Emohaa can reduce symptoms of depression, anxiety, and loneliness in young adults aged 15 to 30. 222 participants with emotional distress were randomly assigned to use the chatbot, receive traditional counseling, or join a waitlist. …

This study looked at whether online laughter therapy could help people on hemodialysis feel less depressed, anxious, and stressed, and improve their quality of life. Sixty-nine adults who were on dialysis took part. They did laughter therapy sessions online. The results showed th…

This study tested a new way to use repetitive transcranial magnetic stimulation (rTMS) to treat depressive episodes in 40 adolescents with bipolar disorder. Instead of the usual front-brain target, researchers stimulated the visual cortex at the back of the brain, aiming to affec…

This study tested a non-invasive brain stimulation technique called temporal interference stimulation (TI) to improve depression in people with bipolar disorder. Thirty-six participants received 10 sessions over two weeks, targeting a deep brain area linked to pleasure and reward…

This small study tested whether adding whole-body hyperthermia (like a sauna session) to cognitive behavioral therapy (CBT) is feasible for adults with major depression. Sixteen participants received up to 8 weekly or 4 bi-weekly sauna sessions along with 8 weekly CBT sessions. T…

This study tested whether adding whole-body hyperthermia (mild heat sessions) to standard cognitive behavioral therapy (CBT) could help adults with major depression. Thirty participants received either real or sham heat sessions alongside weekly therapy. The main goal was to see …

This study tested whether an 8-day creativity camp could help 160 teens aged 12-17 with depression symptoms think more flexibly and feel more positive. The camp included various creative arts activities. Researchers measured changes in depression and anxiety scores using question…

This study tested a computer-assisted cognitive behavioral therapy program called Raising Our Spirits Together (ROST) for rural adults with depressive symptoms. The program was delivered in small groups by local pastors, either online or in person at churches. Researchers compare…

This study tested a program called MOSAIC Plus for pregnant women and mothers of children under 5 who have experienced intimate partner violence and have symptoms of depression or PTSD. The program pairs women with community advocates who provide support and teach skills to impro…

This study tested whether taking buprenorphine (a low-dose opioid) after a ketamine infusion can reduce suicidal thoughts more quickly and effectively than ketamine alone in people with major depression. Fifty adults participated, and researchers measured changes in suicidal idea…

This study tested whether a humanoid robot named HUMANE could help older adults living at home feel less lonely and more connected. Sixty people aged 50 and older used the robot for 6 weeks, interacting with it through music, news, games, and conversation. Researchers measured lo…

This study explores whether locally adapted nature-based health interventions can help people with mild to moderate anxiety, depression, or stress. Around 120 adults will take part in weekly outdoor group sessions for at least 10 weeks, focusing on nature interaction, social conn…

This small pilot study tested whether a single 25mg dose of psilocybin, given with psychological support, could help people with treatment-resistant depression who still struggle with anhedonia—the inability to feel pleasure or interest. Twenty adults took either the full dose or…

This study tested whether a new oral medicine, BI 1569912, can help adults aged 18 to 65 with major depressive disorder. 225 participants were randomly assigned to one of three doses of the drug or a placebo, taken daily for 6 weeks. Researchers measured changes in depression sym…

This study looked at whether bright light therapy helps depression equally well in spring/summer compared to autumn/winter. Over 200 adults with depression received daily 30-minute light sessions for at least a week. Researchers measured symptom changes and followed up for three …

This study compared two well-known talk therapies for depression: cognitive-behavioral therapy (CBT) and acceptance and commitment therapy (ACT). Both were delivered in online group sessions over 8 weeks. A total of 116 adults with major depressive disorder took part. The goal wa…

This study tested whether a 4-week program using active video games (exergames) on the Nintendo Switch could help adults with mental illness feel better and stay motivated. Twelve participants were split into two groups: one played exergames, the other continued their usual routi…

This study tested an online psychological service called eClinic for young adults aged 15 to 35 in Hong Kong who have moderate to severe anxiety or depression. The eClinic offers a private, flexible online platform with therapist-guided self-learning modules. Researchers measured…

This early-phase study tested whether combining psilocybin (the active ingredient in magic mushrooms) with cognitive behavioral therapy is a feasible and acceptable treatment for major depression. Sixteen adults with moderate to severe depression received two doses of psilocybin …

This study tested whether giving clonidine, a blood pressure medication, before electroconvulsive therapy (ECT) could reduce the confusion and agitation that often follows the procedure. ECT is effective for severe depression and bipolar disorder, but up to 65% of patients experi…

This study tested whether a 4-month gym exercise program helps young adults (18-35) taking antipsychotic medication for psychosis or mood disorders feel better in their daily lives. 226 participants were randomly assigned to either continue their usual care or add gym workouts. R…

This study tested a single injection of RE104 in 84 women with moderate-to-severe postpartum depression. The goal was to see if it reduces depressive symptoms better than a low-dose comparison. Results will help determine if this approach is safe and effective for new mothers.

This study tested a new drug, centanafadine, in 337 adults with major depression who hadn't responded well to at least one prior treatment. Some participants took the drug alone, others added it to their current antidepressant. The main goal was to see if it reduced depression sy…

This study tested a 3-week program that helps cancer patients identify their personal strengths (like hobbies, social support, or personal qualities) and use them to cope better. 32 adults with different cancers took part in card-sorting sessions, phone calls, and home exercises.…

This study tested an internet-based cognitive behavioral therapy (CBT) program called AMTE for adolescents with anxiety and depression. Sixty teens were randomly assigned to either the online program or a control group. The goal was to see if the program could reduce symptoms of …

This study tested whether adding a traditional Chinese herbal formula (Xingpi Jieyu) to a standard antidepressant helps people with severe major depression. 100 patients received either the herb plus antidepressant or a placebo plus antidepressant for 8 weeks. Researchers also ch…

This study tested whether a 6-session educational program could help people receiving electroconvulsive therapy (ECT) feel less stigma and anxiety about their mental health treatment. Sixty adult inpatients with conditions like depression or bipolar disorder took part. Those who …

This study tested a Dialectical Behavior Therapy skills training program for older adults (age 50+) who care for a family member with Alzheimer's disease or related dementias. The goal was to reduce suicidal thoughts and feelings. Nine caregivers participated, and the program foc…

This study tested whether adding seltorexant, a sleep-related drug, to standard antidepressants helps improve depression symptoms in adults with major depression and insomnia. About 588 participants who hadn't responded well enough to their current antidepressant took either selt…

This study tested a group therapy program called HUGS for mothers with postpartum depression. The goal was to see if it improves the mother-baby relationship compared to a playtime group. 104 mothers participated, and researchers measured bonding through video analysis. The thera…

This study tested two types of talk therapy—behavioral activation and emotion-focused interventions—for adults with depression. Seven people took part, and researchers tracked their symptoms, mood, and daily functioning over time. The goal was to see if these therapies could redu…

This study tested whether a 12-week home-based walking program could help heart failure patients with depression, frailty, and quality of life. 68 patients were split into two groups: one got standard health education, the other added a walking routine of 3,000 extra steps per se…

This study tested a remote program called "And Now What?" to help prevent depression and anxiety in new mothers. 128 first-time moms in Chile took part, with some receiving the program plus usual care and others only usual care. The program included educational modules, messaging…

This study tested whether extra psychoeducational nursing sessions could improve quality of life, emotional well-being, and reduce anxiety in 120 adults receiving modified electroconvulsive therapy (ECT) for depression, bipolar disorder, or schizophrenia. Half the patients got th…

This study tested an experimental oral drug, GM-1020, in 46 adults with major depressive disorder. The goal was to check safety and see if it can quickly improve mood. Researchers measured side effects and depression scores over 24 hours.

This study tested whether a combination of dextromethorphan and bupropion works better than standard SSRI antidepressants for major depression. 80 adults with moderate to severe depression were randomly assigned to one of the two treatments for 6 weeks. Researchers measured chang…

This study tested whether adding virtual reality (VR) nature experiences to standard treatment helps adults with mild to moderate depression feel better. 45 participants were split into three groups: one used a high-end VR lab setup, another used a simple self-managed VR, and a c…

This study adapted a behavioral activation treatment called BeatIt-MV to help improve mood in minimally verbal autistic adults with depression. Nine adults took part, along with a caregiver. The therapy focused on increasing meaningful activities like recreation and social time. …

This study tested whether a short behavioral program called Acceptance and Commitment Therapy (ACT) could reduce pain and improve function in veterans at risk for persistent pain after knee replacement. 402 veterans were randomly assigned to ACT or an attention control group. Res…

This study tested whether virtual peer support groups, co-led by a mental health clinician and a trained peer specialist, could help veterans with serious mental illness (like schizophrenia or bipolar with psychosis) feel more socially connected and less distressed. Twenty-eight …

This study tested an online program called ORCHID that helps people with HIV feel more positive emotions. The goal was to see if it could reduce depression and improve HIV care. 29 adults from Chicago clinics took part. The program was designed to be used on a phone or computer.

This study looked at whether Acceptance and Commitment Therapy (ACT), a type of talk therapy, could help university students in Malaysia with mild to moderate anxiety, depression, and stress. 32 students either received six weekly online ACT sessions or were placed on a waiting l…

This study tested whether pramipexole, a drug used for Parkinson's disease, can help people with depression who still have trouble feeling pleasure or motivation despite taking standard antidepressants. 85 adults with depression and significant anhedonia took either pramipexole o…

This study tested whether computerized brain-training activities could improve thinking skills and depression symptoms in older adults who were already taking antidepressants. Thirty-eight participants completed the program, and researchers measured changes in mental flexibility,…

This study tested a personalized form of brain stimulation called iTBS for people with major depression. Researchers used MRI scans to target specific brain areas in 68 participants. The goal was to see if this tailored approach could improve depression symptoms more than a sham …

This study tested a version of cognitive behavioral therapy (CBT) that was adapted to fit the cultural background of Canadians of South Asian origin. Researchers worked with 146 adults who had depression or anxiety to see if this tailored therapy could help reduce their symptoms.…

This pilot study tested whether a single dose of a ketone drink could improve information processing and cognition in 28 people with schizophrenia or bipolar disorder. Participants drank either the ketone drink or a carbohydrate drink, then had brain wave tests, cognitive tasks, …

This study tested a version of cognitive behavioral therapy (CBT) that was adapted to be more culturally relevant for Chinese youth in Ontario. 36 participants aged 12 to 21 with anxiety or depression received the therapy from community therapists. The goal was to see if this app…

This study tested whether a single dose of the experimental drug zelquistinel (AGN-241751) can quickly improve depression symptoms compared to a placebo. 251 adults with major depressive disorder took either the drug or a dummy pill, and researchers measured mood changes using a …

This study tested whether playing specially designed video games (MEL-T01 and MEL-S01) for 12 weeks could reduce depression symptoms in adults with major depressive disorder. Over 1000 participants were assigned to either the game therapy or usual care. The main goal was to see i…

This completed study tested whether weekly peer-led social groups could help older veterans struggling with depression and loneliness. Eighteen veterans took part in 16 weeks of group meetings. Researchers measured changes in mood, social support, and loneliness using questionnai…

This pilot study tested a remotely delivered self-management program called TEAM-Red for depressed young African American women who also have risk factors for high blood pressure. 83 women participated in group video sessions over 12 weeks, with researchers tracking changes in de…

This study looked at whether adding pramipexole (a drug used for Parkinson's) for 6 months can safely reduce anhedonia — the loss of pleasure or interest — in people with depression. 55 adults who had already been in a shorter trial took pramipexole alongside their usual treatmen…

This study tested whether low-intensity focused ultrasound, aimed at the amygdala (a brain area linked to emotions), could reduce symptoms of depression, anxiety, bipolar disorder, and PTSD. Twenty-nine adults received daily 10-minute sessions for three weeks. Researchers measure…

This study tested whether a blend of online and in-person therapy (called blended CBT) works as well as standard face-to-face therapy for adults with major depression. 105 participants were randomly assigned to either blended CBT or usual care. Researchers measured depression sym…

This study looked at three ways to manage pain after severe perineal tears (called OASIS) that can happen during vaginal delivery. Sixty-seven women received either a placebo, epidural morphine alone, or epidural morphine plus intravenous ketamine. The goal was to see which optio…

This study tested whether celecoxib (Celebrex), an anti-inflammatory drug, can reduce brain inflammation in people with major depression. 41 adults with depression received 400 mg of celecoxib daily for 8 weeks. Researchers used PET scans to measure inflammation before and after …

This study tested a digital mental health program for adults with depressive symptoms. The program includes nine online modules covering topics like positive thinking, relaxation, and healthy habits. Researchers compared results between people with diagnosed mood disorders and th…

This study tested whether a single 25 mg dose of psilocybin, the active ingredient in magic mushrooms, could reduce depression symptoms better than a placebo (niacin). 347 adults with major depressive disorder received either psilocybin or niacin in a double-blind setup. The main…

This small study tested whether taking aspirin and ketamine together by mouth can help people with treatment-resistant depression. Fifteen adults who had not gotten better with standard antidepressants received the combination alongside their usual medication. Researchers measure…

This study tested a personalized form of transcranial magnetic stimulation (TMS) to treat emotional blunting—a common symptom where people feel numb or disconnected—in 80 adults with depression. Researchers used brain imaging to target the stimulation precisely. The goal was to s…

This study tested a program that helps mothers with depression and their young children (ages 2-4) with behavior problems at the same time. The program combines parenting support with short videos to help moms cope with stress. Researchers wanted to see if treating both together …

This study tested a type of talk therapy called interpersonal psychotherapy (IPT) for women who became severely depressed after losing a baby during pregnancy or shortly after birth. About 199 women in Michigan took part. The goal was to see if IPT helps them recover from depress…

This study tested whether a program called PRISM (Promoting Resilience in Stress Management) could help young adults aged 18-39 who have cancer or desmoid tumors manage anxiety and depression. The program teaches skills like stress management, goal setting, and positive thinking.…

This study tested a 5-week digital counseling program for 54 women who had a pregnancy loss within the past two months. The program focused on emotional support and coping skills. Researchers measured grief and stress levels before, right after, and up to 6 months later to see if…

This study tested an accelerated schedule of theta-burst stimulation, a type of brain stimulation, in 40 people with treatment-resistant depression. Participants received multiple sessions per day targeting the left or both sides of the brain. Researchers measured changes in depr…

This study tested whether the antiviral drug valganciclovir can improve depression symptoms and reduce brain inflammation in people with major depressive disorder who also have a common virus called CMV. Twenty participants took either the drug or a placebo for 8 weeks, and resea…

This early study tested whether a carefully controlled dose of propofol, a common anesthetic, could safely boost brain slow waves in 16 older adults with treatment-resistant depression. Participants received two propofol infusions days apart while researchers monitored brain acti…

This study tested whether a device that sends mild electrical currents to the brain (tDCS) can help treat major depression when used at home. 174 adults with depression used either the active device or a placebo version for 10 weeks. The goal was to see if the active device reduc…

This study tested a program called ENCODE designed to help family caregivers of people with dementia manage stress and communicate better about pain. 452 caregivers were randomly assigned to either the ENCODE program or friendly video calls. The goal was to see if the program imp…

This study tested a counseling program called the Friendship Bench for 106 teens aged 13-18 who have HIV and feel depressed or anxious. The program aims to improve their mood and help them stay engaged in their HIV care. Researchers measured how well the program worked by looking…

This study tested whether an 8-week group therapy program called behavioral activation could help adults with depression in rural Vietnam. The program was delivered at local health stations by trained staff. Researchers measured changes in depression symptoms, distress, and quali…

This study tested an experimental drug called ALTO-203 in 69 adults with moderate major depressive disorder who also had anhedonia (loss of interest or pleasure). Participants received either a low dose, a higher dose, or a placebo, and reported their mood and alertness. The goal…

This small study tested a new virtual reality (VR) therapy called VR-Moodboost in 12 teenagers and young adults with depression. The therapy focuses on increasing positive feelings, like joy and interest, rather than just reducing sadness. Over 12 weekly sessions, participants us…

This study tested a new, non-invasive treatment for major depression called transcranial photobiomodulation (tPBM), which uses near-infrared light on the scalp. Fifty adults with depression received either real light therapy or a sham treatment three times a week for six weeks. T…

This study tested a digital mental health app designed to help young adults (ages 18-25) who engage in nonsuicidal self-injury and are not currently in treatment. The app provides psychoeducation, skill-building exercises, and daily check-ins. Researchers compared a self-guided v…

This study tested a behavioral therapy called BE-SMART-DR in 65 teens and young adults with bipolar disorder or major depression who had suicidal thoughts or past attempts. The therapy teaches self-directed strategies to regularize sleep and other daily rhythms to reduce short-te…

This study tested a mindfulness-based program (including breathing exercises and meditation) in 39 Generation Z nursing students during their clinical internship. The goal was to see if it could improve mental health and reduce anxiety, depression, and stress compared to usual ca…

This study tested whether personalized text messages can help people with depression manage their symptoms. 100 adults with moderate to severe depression received either adaptive texts that learned their preferences, non-adaptive texts, or just educational links. The goal was to …

This study compared two treatments—electroconvulsive therapy (ECT) and intravenous ketamine—in 70 adults whose depression did not improve with standard medications. Over three weeks, researchers measured changes in mood and thinking skills. The goal was to see which treatment wor…

This study tested whether a program combining behavioral activation (helping people do meaningful activities) and medication optimization (adjusting meds) can reduce depression and anxiety in adults 60 and older undergoing heart surgery. 105 participants were split into two group…

This study tested a program that combines counseling (behavioral activation) with medication adjustments to reduce depression and anxiety in adults aged 60 and older who were scheduled for hip or knee replacement surgery. 116 participants were randomly assigned to receive the pro…

This study tested a new drug called ropanicant in 41 adults with moderate to severe major depressive disorder. The main goal was to check safety and side effects, while also measuring how well it improved depression symptoms using a standard rating scale. The trial was open-label…

This study looked at whether taking magnesium supplements alongside the antidepressant fluoxetine can improve cognitive function in adults with major depression. Forty participants took either fluoxetine plus magnesium or fluoxetine alone for six weeks. Researchers measured chang…

This study tested two remotely delivered programs—mindfulness-based cognitive therapy and internet-based cognitive behavioral therapy—against standard remote monitoring alone for reducing depression and substance use related to COVID-19 stress. 113 adults from a health system par…

This study tested an experimental drug called AGN-241751 in 226 adults with major depressive disorder. Participants received either the drug or a placebo to see if it could quickly improve depression symptoms. The trial was completed and aimed to measure changes in mood using a s…

This completed Phase 2b trial tested whether ropanicant, an experimental drug taken twice daily, can reduce symptoms of major depressive disorder. 214 adults with moderate to severe depression received either ropanicant or a placebo for 6 weeks. The main goal was to see if the dr…

This study tested whether a low dose of interleukin-2 (IL-2), a protein that helps regulate the immune system, could improve depressive symptoms in people with bipolar disorder. Fourteen participants already on mood stabilizers received the treatment. The goal was to see if it in…

This study tested an 8-week online program to help people with multiple sclerosis (MS) improve their problem-solving and coping skills. The goal was to see if the program was easy to use and if it helped reduce anxiety and depression. Thirty adults with MS in Lebanon took part. T…

This study tested a therapy called Cognitive Behavioral Therapy for Work Success (CBTw) in 294 veterans with serious mental illness (like depression, bipolar disorder, or PTSD) who were unemployed. The goal was to help them find and keep competitive jobs, which can improve their …

This study tested whether a type of compassion meditation could help Veterans with chronic pain who also have depression or PTSD. 142 Veterans were randomly assigned to either compassion meditation training or a health education group. The goal was to see if meditation could redu…

This phase 2 study tested a daily oral drug called MAP4343 in 126 adults whose depression did not improve with standard antidepressants. Participants took either MAP4343 or a placebo for 6 weeks. The main goal was to see if the drug reduced depression symptoms more than placebo, …

This study tested whether a program that combines behavioral activation (a type of counseling that helps people engage in meaningful activities) with medication optimization (reviewing and adjusting current medications) can reduce anxiety and depression in adults aged 60 and olde…

This study tested an experimental drug called BI 1569912 in 243 adults aged 18–65 with major depression that didn't improve with previous treatments. Participants took either a low, medium, or high dose of the drug or a placebo once daily for 6 weeks, while continuing their usual…

This study compared two common talk therapies—Cognitive Behavioral Therapy (CBT) and Emotion-Focused Therapy (EFT)—for treating depression. 112 adults with moderate or major depression received 14-18 sessions of one therapy. Researchers measured symptom changes and explored why t…

This small pilot study tested whether laughing gas (nitrous oxide) can improve mood in people with major depressive disorder. Eleven participants received either laughing gas or a sedative (midazolam), and researchers used brain scans to look for changes in brain activity. The go…

This study tested whether giving primary care doctors access to an online cognitive behavior therapy program helps treat major depression in rural West Virginia and Kentucky. Over 1,200 adults participated. The goal was to see if remote therapy can improve depression remission ra…

This study tested a 6-week internet-based mindfulness program for adults with depression. 116 participants were randomly assigned to the program or usual care. The goal was to see if the program reduces depressive symptoms and improves well-being, and to understand how mindfulnes…

This study tested a 9-week online mindfulness program for teens aged 12-17 with anxiety or depression. Half of the teens also had a parent or caregiver join the program. Researchers wanted to see if adding a caregiver improved the teen's symptoms. The study was very small (32 par…

This study tested whether taking part in art activities like theatre, dance, visual arts, music, or cinema can improve mental health. 541 adults with psychiatric diagnoses were randomly assigned to either an art program or a waitlist. Researchers measured changes in depression an…

This study tested an optimized multichannel tDCS (a non-invasive brain stimulation device) against standard and sham versions in 60 adults with moderate-to-severe major depression. The goal was to see if the new protocol better reduces depressive symptoms and improves memory and …

This study tested a new parenting program called ADAPT for depressed parents of children aged 6 to 10 with emotional and behavioral difficulties. The program combines emotion regulation skills with parenting techniques. The goal was to see if the program is feasible and acceptabl…

This study tested a mobile app that teaches Acceptance and Commitment Therapy (ACT) to help people with glaucoma cope with anxiety, depression, and emotional distress. Researchers worked with 28 patients to see if the app was acceptable and easy to use. The goal was to lay the gr…

This study tested a new way of giving electroconvulsive therapy (ECT) for severe depression. The goal was to see if a different electrode placement on the head could reduce memory loss while still effectively treating depression. 156 adults with severe depression took part, recei…

This early-stage trial tested the safety of a single dose of zelquistinel, an experimental drug for major depressive disorder, in 68 healthy adults. Researchers monitored side effects and how the drug moves through the body. Since it was a Phase 1 study, it focused on safety and …

This study tested whether a program called MindUP could help lower depression, anxiety, and stress in orphan teenagers in Pakistan. 61 boys aged 11-16 living in orphanages took part. Some did the MindUP program, which teaches mindfulness and emotional skills, while others did the…

This study tested a new approach: having people with major depressive disorder do 30 minutes of moderate exercise right before a therapy session. 40 adults were split into two groups: one exercised on a stationary bike, the other watched nature videos. The goal was to see if exer…

This study tested whether progressive muscle relaxation (PMR) — a technique where you tense and then relax different muscle groups — could help nursing students feel less depressed, anxious, and stressed. Over 100 students were split into two groups; one group practiced PMR three…

This study tested a new way of using deep transcranial magnetic stimulation (Deep TMS) to treat major depression. Researchers compared the new stimulation protocol to the standard one in 104 adults with depression. The goal was to see if the new method is safe and works as well a…

This study tested whether a mobile app with educational videos could help people with a tracheostomy feel less depressed, adapt socially, and recover better. 45 adults who had a tracheostomy and could use a smartphone took part. Some got the app plus standard care, while others g…

This study tested two online courses designed to help paramedics in Singapore manage stress, anxiety, depression, and burnout during the COVID-19 pandemic. 63 paramedics took part, completing six weekly online modules. The goal was to see which course better improved mental healt…

This study tested a type of therapy called Emotion Regulation Therapy - Attention Regulation (AR-ERT) to help people with obsessive-compulsive disorder, generalized anxiety disorder, or major depressive disorder who struggle with repetitive negative thinking. 65 adults in Massach…

This study tested whether a gentle electrical current applied to the scalp (tDCS) can reduce symptoms of major depression, schizophrenia, OCD, generalized anxiety, and insomnia. 320 adults aged 16–65 received multiple sessions over weeks. Researchers measured symptom changes usin…

This study tested whether a smartphone app called FOCUS, along with coaching from trained clinicians, could help people with serious mental illnesses like schizophrenia and bipolar disorder. 191 participants used the app and received coaching over 12 weeks. Researchers measured c…

This study tested a new way to help people with depression that hasn't improved with standard treatments. 60 adults learned to increase activity in a brain area linked to positive memories using real-time feedback from an MRI machine. The goal was to see if this training could re…

This phase 2 trial tested four intravenous ketamine infusions over two weeks in 71 adults with treatment-resistant bipolar depression. Participants received either ketamine or a sedative (midazolam) to see if ketamine could quickly reduce depression symptoms. The study measured c…

This study tested whether an 8-week mindfulness-based cognitive therapy (MBCT) program can reduce stress, anxiety, and depression in pregnant women at risk for psychological distress. 84 women participated, with some receiving MBCT and others getting usual care. The goal was to u…

This study tested a non-invasive treatment called neurofeedback in 157 teens who had attempted suicide. During MRI scans, participants learned to control their own brain activity in real time, targeting areas linked to self-processing and emotion regulation. The goal was to reduc…

This pilot study tested whether screening for depression and offering group therapy could help adolescents in Mozambique. Researchers compared a 10-session group therapy called IPT-AG to usual care at four youth-friendly health clinics. The study enrolled 95 teens and measured ch…

This study tested a program that combines mindfulness training, music listening, and video counseling to help new mothers manage depression and persistent pain after childbirth. The program was designed for use in outpatient care and includes digital tools. 1,720 healthy women wh…

This study tested whether a dynamic LED-light system that changes brightness and color throughout the day could improve depression symptoms in hospitalized patients. 60 adults with major depression were randomly assigned to either a room with the special lighting or standard ligh…

This study tested whether installing special LED lights that mimic sunlight in hospital rooms could help treat depression and improve sleep. Fifteen adults with major depression participated. The goal was to see if the lights were comfortable and if they could reduce depression s…

This study tested an oral drug called LPCN 1154A in 90 women with severe postpartum depression. The goal was to see if it reduces depressive and anxiety symptoms better than a placebo. Participants took the drug or a placebo and were monitored for side effects and mood changes us…

This study tested whether writing about your deepest thoughts and feelings for 15 minutes a day over two weeks can help reduce anxiety and depression in young adults. Participants were split into three groups: writing to themselves, writing to a loved one, or writing a factual da…

This study tested an online workshop for 109 family caregivers of people with dementia. The workshop taught caregiving skills and ways to manage stress and difficult emotions. The goal was to see if the workshop was easy to use and helpful for caregivers, with the hope of improvi…

This study tested a group teletherapy platform called TheraGroup for Black college students dealing with anxiety and depression. Forty students took part in 12 weeks of cognitive behavioral therapy (CBT) coping skills training delivered online in a group setting. The goal was to …

This study looked at whether nature-based activities can help reduce anxiety and depression in teenagers. Researchers worked with 60 adolescents who did not have a psychiatric diagnosis. The study tested a nature therapy program and measured changes in symptoms using standard que…

This study tested a customized mental health app called Wysa in 30 adults with chronic neck or back pain who also had anxiety or depression. The app uses an AI chatbot and human coaches to deliver therapy and mindfulness tools. Participants used the app for one month, and researc…

This study tested whether adding an experimental drug called SEP-363856 to standard antidepressants can better reduce depression symptoms in adults who didn't respond well to prior treatments. About 929 participants took either the drug or a placebo alongside their usual medicati…

This study tested a personalized form of brain stimulation for people with depression who no longer feel pleasure (anhedonia). Sixty adults received either individualized, standard, or fake magnetic pulses to the brain over one week. The goal was to see if tailoring the stimulati…

This study tested whether a single 60-minute session of a videogame called 'ACTing Minds' could improve mental health in 302 adults with mild to moderate depression, anxiety, or stress. The game is based on Acceptance and Commitment Therapy (ACT) and aims to increase psychologica…

This study tested whether adding aticaprant to a standard antidepressant helps adults with major depression who still feel little pleasure or interest (anhedonia). About 444 people took either aticaprant or a placebo pill for 6 weeks. The main goal was to see if depressive sympto…

This study tested whether using MRI scans to guide brain stimulation (TMS) and combining it with talk therapy could help people with major depression. Thirty-two adults with current depression received either real or fake TMS along with cognitive therapy over 6 weeks. The goal wa…

This study tested whether personalizing transcranial magnetic stimulation (TMS) based on an individual's brain structure and activity could improve outcomes for people with treatment-resistant depression. 75 adults received 20 sessions over 4 weeks, comparing fully personalized T…

This study tested a 9-session program that uses cognitive-behavioral techniques to help people living with HIV quit smoking by reducing anxiety and depression. 131 daily smokers who were motivated to quit took part. The goal was to see if the program led to more people staying sm…

This early study tested whether a faster version of transcranial magnetic stimulation (TMS) could work for major depression. Instead of daily sessions for 7 weeks, the accelerated schedule aimed to be more convenient. Only 11 people took part, and the main goal was to see if the …

This study tested an 8-week text messaging program for young adults (ages 18-25) with depression or anxiety who do not want in-person therapy. Some participants got personalized messages tailored by a computer, while others got standard messages or weekly tips. The goal was to se…

This study tested whether giving pregnant trainee doctors extra support—like a smart bassinet, wearable breast pump, 24/7 online perinatal care, and a faculty mentor—could reduce burnout and improve wellbeing. 156 pregnant residents and fellows from four hospitals were randomly a…

This study tested a wearable morning light device (Re-Timer) for women with postpartum depression. 95 women wore either bright or dim light glasses for 60 minutes each morning for 5 weeks. Researchers measured changes in depression symptoms, sleep, and body clock timing. The goal…

This study tested whether a nature-based physical activity group was practical and helpful for university students dealing with depression and anxiety. Six students took part in group therapy sessions that included outdoor activity. Researchers measured attendance, enjoyment, and…

This study tested whether an 8-week mindfulness-based stress reduction program could lower depression, anxiety, stress, and hopelessness in parents of children with autism. 96 parents took part in weekly 60-minute group sessions. The goal is to see if this simple, non-drug approa…

This study looked at whether using a person's DNA to pick an antidepressant works better than usual care for cancer patients with depression or anxiety. About 99 adults with cancer took part. Half got a DNA-guided choice of medication, and the other half got standard care. Resear…

This study tested whether a collaborative care model, where doctors, nurses, and mental health specialists work together, helps adults with depression more than standard care. 325 Danish adults with depression took part. The goal was to see if this team approach reduces depressio…

This study tested a 10-week peer support program called 'Paths to everyday life' for adults with mental health difficulties. Participants were randomly assigned to either the peer support group plus usual services, or usual services alone. The goal was to see if the program impro…

This study tested a collaborative care model for people with depression in general practice. 389 Danish-speaking adults with depression were randomly assigned to either collaborative care (involving a care manager and stepped treatments like therapy and medication) or standard co…

This study tested whether inhaling cang-ai volatile oil (mugwort oil) for one hour daily could help ease depression. 60 people with depression were randomly assigned to receive either mugwort oil or bergamot oil. Researchers used brain imaging and depression questionnaires to mea…

This small pilot study tested an accelerated version of theta-burst stimulation, a type of magnetic brain stimulation, in 7 adults with bipolar depression that didn't respond to standard treatments. All participants received the active treatment, and researchers measured changes …

This study tested whether a 45-minute chat with an AI bot could help Indian school kids (grades 6-8) feel less anxious or depressed. The bot taught a 'growth mindset'—the idea that you can improve with effort. About 383 students took part, with half getting the full chat and half…

This pilot study tested a brief virtual mindfulness program called RECLAIM in 36 veterans who had difficulty adjusting to civilian life after service. The program aimed to reduce depressive symptoms and improve community reintegration. Participants completed questionnaires about …

This study tested a program called MOSAIC Plus for 15 pregnant women and mothers of young children who had experienced intimate partner violence and had symptoms of depression or PTSD. The program lasted 6 months and aimed to reduce those symptoms and prevent further violence. Th…

This study followed 90 veterans with obesity who took GLP-1 medicines (semaglutide or tirzepatide) for six months. Researchers found that participants reported significant improvements in depression symptoms, eating disorder behaviors, and overall quality of life, including bette…

This study tested a text messaging program designed to reduce the risk of major depression in pregnant and postpartum women. The program sent tailored texts with links to videos and a chat feature where participants could talk with each other. The study included 40 women who were…

This study tested whether an 8-week mindfulness program could reduce depressive symptoms in new mothers. 70 women in Hong Kong with mild to moderate postnatal depression were split into two groups: one took the mindfulness course, the other received a booklet with general advice.…

This study tested two types of online therapy for anxiety and depression in 2477 adults. Participants received either a cognitive behavioral treatment or a psychodynamic treatment, delivered over 8 or 16 weeks, with or without a support forum. The goal was to see which combinatio…

This study tested a 10-week, at-home cognitive training program for 9 veterans with major depression and a recent suicide attempt. The program aimed to improve decision-making and reduce depression through problem-solving exercises delivered via video calls. Early results suggest…

This study tested whether a natural substance called pregnenolone can help reduce depression in women going through menopause or perimenopause. 73 women took either pregnenolone or a placebo for several weeks. Researchers measured changes in mood, anxiety, thinking, and quality o…

This study tested a non-invasive brain stimulation technique called iTBS for treating depression. 73 adults with moderate depression received either real or sham (placebo) stimulation daily for two weeks. Researchers measured changes in mood, thinking skills, and brain scans to s…

This study tested a short talking therapy called CALM for advanced cancer patients with depression. It involved 90 people in Korea and aimed to see if the therapy was practical and helpful. The therapy focuses on managing symptoms, relationships, and finding meaning.

This study tested a non-invasive brain stimulation technique called HD-tACS in 60 adults with depression who had suicidal thoughts. The goal was to see if it could reduce those thoughts and understand how it works in the brain using MRI and EEG scans. The treatment is painless an…

This small pilot study tested whether cannabis oil (with different ratios of CBD to THC) could help with insomnia in people who also have major depression. Fourteen adults took either a high-CBD oil, a low-CBD oil, or a placebo for a short time. The main goal was to see if a larg…

This study tested whether an AI voice coach called Lumen can help adults with mild-to-moderate depression or anxiety. 200 participants were randomly assigned to receive problem-solving training from Lumen, a human coach, or a waitlist. The goal was to see if the AI coach could im…

This study tested whether a probiotic called Weizmannia coagulans BC99 can reduce symptoms of anxiety and depression in stressed adults. 79 people took either the probiotic or a placebo for 8 weeks. Researchers measured changes using standard depression and anxiety rating scales.…

This study tested whether adding a social support program to standard therapy helps trauma-affected refugees with PTSD. 196 unemployed refugees received either standard treatment or standard treatment plus collaboration with municipal social services. The goal was to improve dail…

This study tested a simple web-based platform called Adhere.ly to help therapists and their clients with therapy homework. 79 adults with anxiety or depression took part. The goal was to see if using the tool improved symptoms and quality of life compared to standard therapy alon…

This study tested whether providing overnight infant care and parenting support helps new mothers with substance use disorder living in residential treatment programs. 41 mothers participated, and researchers measured how many enrolled, completed the program, and gave feedback. T…

This completed Phase 4 study tested valbenazine in 59 adults with tardive dyskinesia (involuntary muscle movements) caused by psychiatric medications. Participants had schizophrenia, bipolar disorder, or major depression. Over 24 weeks, researchers measured changes in quality of …

This study tested whether screening pregnant women for depression and anxiety and providing tailored online therapy could prevent these conditions after childbirth. Over 3,300 women participated, with some receiving screening and internet-based cognitive behavioral therapy (iCBT)…

This study looked at whether a 4-week program of group exercise, walking, and education could improve depression, anxiety, quality of life, and spinal mobility in elderly nursing home residents. 44 people aged 65 and older took part. The goal was to see if simple, supervised acti…

This study tested whether eating dates or taking moringa can help new mothers with postpartum depression. 363 mothers with mild to severe depression and low breast milk production were split into three groups: dates, moringa, or a control group. After 28 days, researchers measure…

This study tested a non-invasive brain stimulation technique called HD-tDCS on 57 adults with depression. The goal was to see if it could reduce physical symptoms like aches and fatigue, which often accompany depression. Participants received either real or fake stimulation, and …

This study tested whether an 8-week mindfulness-based stress reduction program could lower stress, anxiety, depression, and cortisol levels in infertile women. 84 women participated, with half taking the program and half serving as a control group. The goal was to see if mindfuln…

This pilot study tested a mindfulness-based cognitive therapy program, called Quiet Focus, in 12 older Black adults with chronic pain and mild depression. The goal was to see if the program is acceptable and helpful, and to gather information for a larger future study. Participan…

This study tested whether a single dose of ketamine, given during spinal surgery, can reduce depressive symptoms afterward. 110 adults with moderate to severe depression received either ketamine or a saltwater placebo. The goal was to see if ketamine could lower depression scores…

This study tested a therapist-guided online program called AMOR for pregnant women and new mothers with ADHD. 31 participants listened to podcasts and attended online group sessions. The goal was to see if the program was easy to use and helpful for managing ADHD, stress, anxiety…

This study looked at whether doing Zumba for 10 weeks could help reduce anxiety and depression in healthy adults aged 40 to 65. Forty people were split into two groups: one did Zumba three times a week, and the other continued their normal routine. Researchers measured mood befor…

This study tested whether a new drug called BHV-7000 can safely reduce depression symptoms in adults with moderate to severe major depressive disorder. About 336 participants took either the drug or a placebo for 6 weeks, and doctors measured changes using a standard depression r…

This study tested a psychoeducational program based on the Watson Human Caring Model to reduce depressive symptoms and strengthen mother-infant bonding after childbirth. 88 pregnant women participated. The program covered topics like postpartum depression, baby care, and bonding.…

This study tested a brief 4-session Zoom program for first-time mothers to help them better understand their baby's thoughts and feelings. Sixty-six mothers with babies aged 1-5 months took part. The program teaches skills like recognizing emotions and reading baby cues. Research…

This study tested whether 8 weeks of psychodrama group sessions could help new mothers with babies in the NICU feel less depressed and more forgiving. 23 women took part, with 11 attending the sessions and 12 receiving no extra support. Results showed that the psychodrama group h…

This Phase 3 trial tested whether solriamfetol, a drug used for sleepiness, can safely ease depression symptoms in adults with major depressive disorder. 346 participants received either solriamfetol or a placebo daily. Researchers measured changes in depression scores and tracke…

This early-stage trial tested the safety and tolerability of a new drug called NH102 in 40 healthy adults. Participants received either the drug or a placebo to check for side effects and how the drug moves through the body. The study is complete, but it does not yet test if NH10…

This study tested whether taking a 15-20 minute power nap each day for six weeks could improve sleep quality, reduce depression symptoms, and lower stress in healthy workers. Forty volunteers, including both daytime and shift workers, participated. Researchers measured changes us…

This study tested a type of brain stimulation called theta burst stimulation (TBS) to see if it could reduce depression symptoms. 21 adults with current depression received the treatment, and some also got positive affect training. The main goal was to measure changes in depressi…

This study tested whether daily smell training over 12 weeks can improve mood and smell perception in 150 people with mild depressive symptoms or major depression. Participants practiced smelling different odors each day. Researchers measured changes in smell ability and emotiona…

This study tested whether very small, non-hallucinogenic doses of psilocybin (the active ingredient in magic mushrooms) can safely improve mood in people with major depression. Thirty-nine adults received either psilocybin or a placebo, then switched. Researchers measured changes…

This early-stage study tested a new drug called ENX-104 in 48 adults with major depressive disorder who also experience anhedonia (loss of interest or pleasure). The main goal was to check the drug's safety and how the body processes it. The study is now complete, and results wil…

This study tested whether four weekly doses of ayahuasca (a plant-based psychedelic drink) or esketamine (a nasal spray) could reduce symptoms in 22 adults with severe major depression. Participants were randomly assigned to one treatment, and their depression levels were tracked…

This study tested a new treatment called transcranial pulse stimulation (TPS) for people with major depression. 80 adults received either real TPS or a fake (sham) version to see if it safely reduces depressive symptoms. The goal is to find out if this non-invasive brain therapy …

This study tested a single 25mg dose of psilocybin in 20 adults with depression that didn't respond to standard treatments and who also had ongoing suicidal thoughts. The goal was to see if the drug is safe and tolerable in this high-risk group. Participants received the dose in …

This study looks at how good or poor sleep quality influences quality of life, depression, and fatigue in people with multiple sclerosis. Researchers will survey about 121 adults with MS to measure their sleep patterns and link them to these health outcomes. The goal is to better…

This study aims to reduce the number of people with depression who do not receive treatment. It compares two approaches: one where people only get a brief psychological therapy at a health center, and another where they also receive community support to encourage them to seek and…

This study looks at whether a smartphone-based program can help veterans with depression begin and continue mental health treatment. Researchers will analyze medical records to find out who struggles to engage in care, then test an eHealth tool that lets veterans track their mood…

This completed study looked at how the brain processes reward signals to improve mood in people with depression. Researchers used brain scans, a mild magnetic stimulation technique (TMS), and a single injection of buprenorphine (a painkiller) to see how these affect brain activit…

This study developed and tested a new questionnaire called the Excessive Emotional Behaviors Scale (EEBS) for Chinese adults experiencing anxiety or depression. Researchers interviewed 18 people and surveyed 637 participants to refine the scale, which measures behaviors like avoi…

This study looked at how depression in mothers affects their interactions with their babies and the child's development. Researchers observed 701 mothers and their infants at home and in a lab when the babies were 5, 12, and 24 months old. The goal was to understand differences i…

This study looked at whether brain activity patterns can predict how well people with major depression or social anxiety respond to cognitive behavioral therapy (CBT). Over 200 participants were randomly assigned to 12 weeks of CBT or supportive therapy. Researchers measured brai…

This study investigates how a medication called lorazepam, which boosts the calming brain chemical GABA, changes emotional brain activity in people with psychosis. Participants aged 16–60 with conditions like schizophrenia or bipolar disorder, along with healthy volunteers, will …

This study looked at 30 adults aged 40-70 with treatment-resistant depression to see if changes in thinking skills (like memory and attention) could predict when depression improves. Researchers measured mood, daily function, and cognitive abilities before and after starting a ne…

This study looked at nearly 2,000 people from the community to understand how depression, anxiety, and migraine are passed down through families. Researchers interviewed family members of all ages, including children as young as 8, to track patterns of these conditions over time.…

This study used brain scans (fMRI) to look at how people process emotions and make decisions, comparing those who have attempted suicide, those with past suicidal thoughts, depressed patients without suicidal history, and healthy controls. The goal was to find brain activity patt…

This study tested whether a 10-week recovery program, co-led by a peer with mental illness and a professional, is feasible for people with mental illness in Taiwan. Twenty participants completed the program, which focused on recovery concepts, strengths, and goal setting. Researc…

This study looked at 15 people with depression who experienced temporary dissociative states (feeling disconnected from reality) while taking Esketamine. Researchers used interviews to understand these experiences better. The goal is to learn more about this side effect to improv…

This study watched 60 adults getting electroconvulsive therapy (ECT) for severe depression to see if their need for anesthesia changed over multiple sessions. Researchers measured the dose of anesthetic used each time and how it related to seizure quality and recovery. No new tre…

This study looked at what makes it hard for new moms with postpartum depression to get mental health care, especially online. Researchers interviewed 10 women and then tested a virtual patient navigation program with 26 moms over 2 months. The goal was to see if the program was e…

This study screens women who gave birth in four French hospitals for postpartum depression and anxiety during the COVID-19 pandemic. Participants fill out three questionnaires shortly after delivery and again about a month later. The goal is to measure how common postpartum depre…

This pilot study tested a new type of brain training called neurofeedback for people with depression. Participants learned to control their own brain activity using real-time feedback from both EEG and fMRI scans. The goal was to see if combining these two methods could help impr…

This completed study looked at 1,740 newly married couples to see if the bacteria in their mouth, eyes, and gut are linked to sleep problems, vision issues, and mood. Participants provided samples and completed surveys about sleep, anxiety, depression, and dry eye symptoms. The g…

This study follows couples who gave birth in either a midwifery-led birth unit or a standard obstetric unit in France. Researchers want to see if the type of care affects parents' mental health, especially post-traumatic stress, and the child's development up to two years later. …

This study looked at whether listening to upbeat music can change how people with depression perceive emotions in faces and voices. Researchers compared the effects of positive and neutral music in 39 adults with and without depression. The goal was to see if positive music could…

This study looked at whether the natural bacteria in your gut are linked to mood changes after having a baby, including postpartum depression. Researchers collected samples from 30 pregnant women before and after delivery to see if certain gut bacteria patterns relate to emotiona…

This study used brain scans to look at two things in people with depression or bipolar disorder: a glutamate receptor called mGluR5 and the density of connections between brain cells (synapses). Researchers compared 120 participants, including healthy volunteers, using PET and MR…

This study tested a digital suicide prevention program for teens in pediatric primary care. Thirty at-risk youth aged 12-17 and their parents used the tool, which helps doctors identify and address suicidal thoughts and behaviors. The goal was to see if the program is practical a…

This study tested whether daily mood check-ins via a mobile app could help predict and prevent depression in people who recently had a stroke. Over 400 participants used the app for three months while researchers tracked their emotional symptoms. The goal was to see if this kind …

This study followed nearly 10,000 Stanford undergraduates over their college years to understand how social ties, loneliness, and stress relate to anxiety and depression. Researchers used surveys and social network analysis to track changes in mental health. The goal is to create…

This study tested a web application called PRATICAdr 2.0, designed to help healthcare workers on sick leave due to common mental disorders like depression or anxiety return to work. The app helps coordinators track progress and improve communication. Researchers compared workers …

This study looked at whether signals from the heart and brain during transcranial magnetic stimulation (TMS) can predict which people with major depression will get better. Thirty-two adults received an accelerated TMS treatment over 5-8 days while their heart rate was monitored …

This completed study looked at how rising temperatures affect people with chronic conditions like heart disease, diabetes, and depression. Researchers in Germany and Italy surveyed 176 patients to see what symptoms they experienced during heat and what protective steps they took.…

This completed Phase 1 trial tested whether the experimental drug SP-624 affects brain electrical activity in 26 people — some healthy, some with major depression. Participants took SP-624 or a placebo daily for two weeks. Researchers used EEG and AI to look for changes in brain …

This study used MRI brain scans and computer tasks to understand how people who attempted suicide make decisions. Researchers compared three groups: those who used violent means, those who used non-violent means, and healthy volunteers. The goal was to find brain activity pattern…

This study looked at 62 children with cerebral palsy (ages 2-18) and their primary caregivers to understand how the children's sleep problems relate to caregiver burden and mental health. Researchers used questionnaires to measure sleep quality in both children and caregivers, al…

This study tested an 8-week parenting program called Circle of Security-Parenting for mothers with depression and infants showing signs of social withdrawal. Researchers compared it to standard care to see if it improves how mothers interact with their babies and helps the child'…

This completed Stanford study looked at whether video-recorded facial expressions and speech patterns can reflect a person's mood. Eleven adults with depression or epilepsy had electrodes temporarily placed in their brains to record brain activity. Researchers stimulated certain …

This study tested whether artificial intelligence (AI) can realistically simulate conversations between a therapist and a person with a mental health problem. Researchers used 520 simulated sessions to see if the AI could follow proper therapy techniques. The goal is to use these…

This study looked at 92 adults aged 55 and older with major depression to see if their brains had amyloid plaques, which are linked to Alzheimer's disease. Researchers used a special PET scan to measure plaque levels after 8 weeks of antidepressant treatment. The goal was to unde…

This study aimed to create a better way to measure apathy—a lack of motivation and goal-directed behavior—in people with brain diseases like frontotemporal dementia and depression. Researchers used video recordings and body sensors to track behaviors in a real-life setting. 66 he…

This study looked at 56 adults with fully remitted depression who wanted to stop their antidepressant. Researchers wanted to see how much of the withdrawal symptoms are caused by the drug itself versus the person's expectations. Participants were randomly assigned to either stop …

This study tested whether a smartphone app that tracks how you type (speed, backspace use, autocorrect) can help monitor mood and thinking problems in people with mood disorders like depression or bipolar disorder. 132 adults aged 25-50 took part. The goal was to see if this simp…

This study looked at how thinking skills and brain activity differ in people who self-harm compared to those who don't. Researchers interviewed 316 adults and gave them thinking tests, with some also having brain scans. The goal was to better understand self-harm to help create m…

This study looked at why some people with depression feel better after taking a placebo (a sugar pill with no active drug). Researchers used brain scans and other tests to find biological markers linked to this placebo response. The goal is to improve future depression treatments…

This study tested whether a training program called Modeling to Learn (MTL) helps clinic staff improve how many veterans start and finish evidence-based treatments for PTSD, depression, and opioid use disorder. The program uses computer simulations to let staff try out changes to…

This study interviewed 12 people with persistent major depression who were referred to a group exercise program. Researchers wanted to understand what makes it easier or harder for them to take part. The goal is to help clinics create exercise programs that better fit the needs o…

This study looks at how certain genes behave in people with major depression compared to healthy individuals. Researchers collected blood samples from 30 participants to measure the activity of 21 specific genes. The goal is to better understand how depression changes over time a…

This study interviewed 12 mothers who had participated in HUGS mother-baby therapy groups for postpartum depression. The goal was to understand how the program affected their bond with their baby and their daily lives, 6 to 12 months later. Researchers used in-depth interviews to…

This study tested a free chatbot called Rosie that gives pregnant women and new moms instant, reliable health information from trusted sources. 400 minority women who were pregnant or had an infant under 6 months used the chatbot to ask questions and get answers. The goal was to …

This study looked at how common postpartum depression is among 401 mothers visiting health clinics in Mekelle, Ethiopia, and what factors might increase their risk. Mothers completed a questionnaire about their mood, social support, and health. The goal is to help doctors and pol…

This study looked at how the COVID-19 pandemic affected the mental health of 193 Amish and Mennonite adults who already had depression, anxiety, or bipolar disorder. Participants filled out surveys about their symptoms and pandemic-related stress over two years. The goal was to u…

This small study tested whether a gentle brain stimulation technique called HD-tDCS could improve the effects of cognitive behavioral therapy (CBT) for people with depression, anxiety, or PTSD. Twenty participants received either real or fake stimulation daily for five weeks whil…

This study tested whether smartphone notifications could improve mood, physical activity, and sleep in over 1,000 medical interns. Participants received daily mood, activity, or sleep notifications through a mobile app. The study measured mood scores, step counts, sleep duration,…

This study tested whether sending outreach messages (via secure messaging or phone) to people from racial and ethnic minority groups could help them start depression treatment after a new diagnosis. The study included 309 adults who had not started treatment within 30 days of dia…

This study looks at whether forgiving people's medical debt can improve their mental health, reduce anxiety and depression, and help them get the medical care they need. Over 15,000 adults who owed medical debt were randomly selected to have their debt forgiven by a charity. Rese…

This completed study followed over 7,500 Chinese patients aged 65 and older who had non-cardiac surgery. Researchers measured how many developed anxiety or depression symptoms afterward using standard questionnaires. The goal was to find out how common these symptoms are and what…

This completed study from the University of Toronto looked at whether certain gut bacteria are linked to anxiety, depression, and panic disorders. 500 adults provided stool samples to test for H. pylori and other bacteria. The goal was to understand possible root causes, not to t…

This study looked at three digital coping strategies—reappraisal, distraction, and relaxation—to help children aged 9-12 whose parents are separated or divorced. The goal was to see which tools best reduce anxiety, depression, and behavior problems. 148 children and a parent took…

This study looked at how a gentle nerve stimulation device (tVNS) affects stress-related brain activity and body functions in people with major depression. Researchers compared active stimulation to a sham (fake) version in 62 adults, focusing on differences between men and women…

This study looked at how electrical brain stimulation influences approach and avoidance behavior in 13 patients with deep brain stimulators for OCD, depression, or epilepsy. Participants played a computer task with their stimulator turned on and off. The goal was to understand br…

This study looked at how often to check in with people after they leave a psychiatric hospital to help lower their suicide risk. About 500 patients in Shenzhen, China, received brief contact interventions (like texts or calls) at different frequencies over a year. The goal was to…

This pilot study adapted a behavioral intervention called BECOME to help people with dementia or mild cognitive impairment and their caregivers manage non-communicable diseases (like diabetes and high blood pressure) and common mental health conditions (like depression and anxiet…

This early-stage study tested a new oral drug, SEP-380135, in 43 adults with schizophrenia or major depression (including bipolar disorder). The main goal was to check its safety and how the body processes it. Participants took multiple doses and were monitored for side effects, …

This completed study used fMRI brain scans to understand how people with major depression can disengage from negative thinking. Researchers analyzed brain activity patterns during different thinking states in 89 participants. The goal was to identify the neural circuits involved …

This study looked at 545 people with major depressive disorder who also have anhedonia (loss of interest or pleasure) and whose current antidepressants weren't working well enough. Researchers tracked their symptoms, treatments, and outcomes to better understand the disease and h…

This study tested a program called Recovery Bridge, where trained peer specialists (people with lived experience of mental illness) helped veterans leaving a psychiatric hospital connect to outpatient care and community life. Fifteen veterans took part to see if the program was f…

This study looked at 39 children with asthma to see if those with depression have a different type of airway response. Researchers tested whether an anticholinergic inhaler (ipratropium) works better in depressed versus non-depressed children. The goal was to better understand th…

This study tested a new afterschool program where college students mentor middle schoolers to help them be more active and improve their mood. The program was designed for teens with depression symptoms who might not otherwise join afterschool activities. Researchers measured how…

This study looked at whether schema therapy, a type of talk therapy, could help people with depression that hasn't gotten better with usual treatments. Two participants received 30 therapy sessions over about a year. The goal was to see if this approach is feasible and to learn h…

This study looked at how children ages 8 to 17 use smartphones and tablets, including social media and games, and how that relates to their mental health, sleep, and physical activity. Over 900 children and their parents used the Aura app and completed surveys for three months. T…

This study checked whether the Turkish version of the Cardiac Depression Scale (CDS) works well for people with heart disease. Researchers tested 360 Turkish adults with various heart conditions to see if the scale accurately measures depression. The goal is to give doctors a rel…

This Norwegian study followed 169 elderly patients with depression for three years to see how they fared after specialist treatment. Researchers tracked whether depression returned or became chronic, and also checked for signs of dementia. The goal was to better understand the lo…

This study tested a new way to treat depression that doesn't respond to medication. Researchers used a brain stimulation technique called rTMS, but with a twist: they monitored brain activity in real time to adjust the stimulation for each person. 44 adults with medication-resist…

This completed study looked at 400 people with both heart disease and a mental health condition (like depression or anxiety). Researchers used questionnaires, blood tests, and imaging to find shared risk factors and biological markers. The goal was to better understand how these …

This study looked at nearly 10,000 patients to see if combining information from clinical trials and electronic health records can help predict which depression medication works best for each person. Researchers analyzed data from people prescribed duloxetine or vortioxetine. The…

This study looked at 120 adults to see if anxiety and depression are linked to a common tooth infection called apical periodontitis. Participants had dental exams and filled out questionnaires about their mental health. The goal was to better understand how emotional well-being a…

This study tested whether an anti-stigma training program for healthcare providers improves attitudes toward people with mental illness or substance use problems. About 485 staff and clients from six health centers took part, with three centers receiving the training and three no…

This study looked at whether levels of certain minerals (like selenium, magnesium, and zinc) in the blood are different in women with fibromyalgia compared to healthy women. It also checked if those mineral levels are linked to how severe the disease is, or to anxiety and depress…

This completed study tested whether noninvasive brain stimulation can be personalized by measuring heart rate responses. Researchers mapped the scalp to find the best spot for stimulation in 34 healthy participants and people with depression, anxiety, and gut issues. They compare…

This study tested a simple program to help new mothers who are at higher risk for health problems after giving birth. 220 Black mothers who delivered at the Hospital of the University of Pennsylvania took part. Some received a helpful pamphlet and a patient navigator they could c…

This study tested whether adding psychodramatic role-playing to standard childbirth classes could reduce postpartum depression and improve self-confidence and social support in first-time mothers. 57 pregnant women participated, with one group taking regular classes and the other…

This study tested how low (1 Hz) and high (20 Hz) frequency repetitive transcranial magnetic stimulation (rTMS) changes brain activity in 30 healthy adults. Participants received both types of stimulation in separate sessions, and their brain waves were measured before and after.…

This study looked at how often insomnia occurs in people hospitalized for psychiatric conditions. Researchers checked 427 patients at 11 hospitals in Switzerland and Germany. They also explored whether age, gender, or type of disorder made insomnia more likely.

This study examined 24 adolescents (ages 14-18) with and without depression to see if their brains respond differently to insulin. Participants received insulin or a placebo nasal spray, and MRI scans measured brain activity and blood flow. The goal was to understand if brain ins…

This study looked at how keeping a diary helps parents and healthcare workers deal with the stress of having a baby in the neonatal unit. Fifteen parents of premature or low-weight babies and hospital staff took part. Researchers analyzed the diaries to understand emotions, stres…

This study looked at whether genetic testing can help doctors choose better medicines for depression, acute pain, and chronic pain. Over 4,000 people were screened to join one of three trials. The goal was to see if matching drugs to a person's genes improves outcomes compared to…

This study tested a program called NAVIGATE, which provides coordinated care for youth and young adults (ages 14-35) who have had a first episode of psychosis. The goal was to see if NAVIGATE helps improve recovery, reduce hospital stays, and lower healthcare costs compared to st…

This study looked at anhedonia, a symptom of depression where people lose interest or pleasure in activities. Researchers used brain scans, blood tests, and questionnaires to understand this symptom in 123 young people. Some participants also tried treatments like brain stimulati…

This study looks at how mood and brain activity are linked in adolescent girls to find genetic and brain-based clues that might predict depression. One hundred healthy girls aged 12-14 and their mothers took part over six months. The teens completed interviews, questionnaires, co…

This study tested a modified behavioral parent training program for children with ADHD who also have peer problems. The program aimed to increase parent engagement, especially for parents with their own ADHD or depression symptoms. Thirty-three parents participated, and researche…

This completed observational study looked at 15 women aged 20-50 who had experienced domestic physical violence and sought help from a social service institution. Researchers wanted to see if a woman's ability to manage daily tasks and take part in social roles was linked to her …

This study tested a new way to target brain stimulation for depression. 50 adults with major depression received a single session of transcranial magnetic stimulation (TMS) aimed at their individual brain networks. The goal was to see if personalized targeting could improve brain…

This study tested a new digital tool called CBTpro that uses artificial intelligence to help therapists improve their skills in cognitive behavioral therapy for psychosis (CBTp). Over 600 participants, including therapists and their clients with conditions like schizophrenia or b…

This completed study looked for biological markers of suicide risk in 97 adults with major depressive disorder. Researchers used brain scans to measure how participants respond to pain, reward, and attention. The goal was to find stable brain-based signs that could help identify …

This study tested whether a generic selegiline skin patch works the same as the brand-name EMSAM patch. Twelve healthy adults wore both patches to measure how much drug got into their blood and to check for skin irritation. The goal was to see if the generic version is a safe and…

This study tested whether a brain wave measurement called mismatch negativity (MMN) can help match veterans with mental illness to the most effective cognitive training program. 100 veterans with conditions like schizophrenia, PTSD, or mood disorders participated. The goal was to…

This pilot study looked at whether giving donor human milk instead of formula to full-term babies whose mothers received antibiotics during labor could improve their gut bacteria and health. The study included 105 infants born vaginally at full term. Researchers compared the babi…

This completed study surveyed 3,100 adults in Slovakia to find out how many people have mental disorders like depression, anxiety, PTSD, or addiction. Researchers used a standard interview tool to measure current and lifetime rates, and looked at who gets help and who doesn't. Th…

This study looked at 300 people to see if depression causes changes in blood cells that show signs of early aging and stress. Researchers measured telomere length and oxidative stress levels to find genetic markers that could help doctors understand how severe a person's depressi…

This pilot study tested an automated phone system called 'My Coach Connect' for people with chronic mental illness. Participants called in twice a week to answer questions about how they were doing. The goal was to see if the system was easy to use and helpful for both patients a…

This study tested a program called IPS-MA, which helps people with mood or anxiety disorders find and keep jobs or return to school. 326 adults who were unable to work within three months took part. The goal was to see if this support, added to their usual treatment, helped them …

This study tested an 8-month program called 'Meaningful Activities and Recovery' (MA&R) for people with mental illness. The program helps people take part in activities that matter to them. 139 adults took part to see if the program improves activity engagement, recovery, and qua…

This study tested whether combining mental health treatment with job coaching helps people on sick leave due to anxiety, depression, stress, personality disorders, or functional disorders return to work. 900 participants in Denmark received either the combined service or usual ca…

This study looked at 206 medical residents in France to see if their physical activity levels are linked to anxiety, depression, and burnout. Participants filled out online surveys about their exercise habits and mental health. The goal is to understand whether staying active mig…

This study looked at how inflammation affects the brain's reward system in 40 younger women with depression. Participants received either an endotoxin (to trigger temporary inflammation) or a placebo, and researchers measured changes in how they responded to rewards like money or…

This study looked at how social factors like income, housing, and stress, along with depression, affect blood vessel health in low-income racial and ethnic minority adults. Researchers measured depression, anxiety, stress, and social needs using questionnaires. The goal was to un…

This study tested a program called iCOT to improve how occupational therapy interns communicate with patients in mental health settings. The program included online training and feedback from patients, supervisors, and experts. Researchers compared interns who received iCOT to da…

This study tested a program called SLAC that helps Veterans who drink heavily and have mental health issues like PTSD or depression get connected to alcohol care. 140 Veterans from VA primary care took part. The goal was to see if the program is practical and liked by Veterans an…

This Stanford study explores how brain circuits relate to anxiety and depression. 167 participants with recent symptoms (no diagnosis needed) undergo brain scans and cognitive tests. Some also receive a 12-week course of pramipexole medication or rTMS therapy. The goal is to unde…

This study tested a mobile app called Baby2Home designed to help new families get the healthcare they need after childbirth. Over 600 parents and their babies took part, with some using the app and others getting usual care. The goal was to see if the app improved checkups, vacci…

This study tested whether prosthetists—specialists who fit artificial limbs—can screen for common but often unnoticed health problems like depression, nerve damage, and poor blood flow in people who have had a leg amputation. Seventy participants were split into two groups: one r…

This study used MRI and PET scans to examine the glutamate system in people with major depression, PTSD, or bipolar disorder. Researchers aimed to understand how a specific glutamate receptor (mGluR5) relates to these conditions. 180 participants aged 18-70 completed cognitive te…

This study tested whether a systematic phone call from a medical student, supervised by a general practitioner, could reduce hospitalizations in patients with chronic heart or mental health conditions during the COVID-19 lockdown in France. Over 22,000 patients aged 70 and older …

This study followed 300 pregnant women to understand why some develop mood disorders like depression or bipolar episodes after giving birth. Researchers collected genetic, hormonal, and environmental data to find patterns that could predict these episodes. The goal is to better i…

This study looked at whether people with long-term neck pain (cervical myofascial pain syndrome) are more likely to have a 'Type D' or distressed personality and feel stigma about their condition. Researchers compared 54 patients with healthy individuals using questionnaires. The…

This study looked at how people with current depression, those who have recovered from depression, and healthy people react physically to emotions. Researchers measured heart rate, breathing, skin sweat, and brain blood flow during emotional tasks. The goal was to understand diff…

This study tested whether keeping a hospital diary during a child's stay in the pediatric intensive care unit (PICU) could improve mental health outcomes for families. Over 400 families participated across four PICUs in Rio de Janeiro. Researchers measured anxiety, depression, PT…

This study tested a program called Collaborative Decision Skills Training (CDST) to help veterans with serious mental illness (like schizophrenia or major depression with psychosis) work more closely with their doctors in making treatment decisions. The program involved eight wee…