Could a wakefulness drug lift depression? new trial tests solriamfetol

NCT ID NCT06360419

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This Phase 3 trial tested whether solriamfetol, a drug used for sleepiness, can safely ease depression symptoms in adults with major depressive disorder. 346 participants received either solriamfetol or a placebo daily. Researchers measured changes in depression scores and tracked side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Solriamfetol

What this could lead to

If it works, this could offer a new medication option for people with major depression.

What could go wrong

This is a single Phase 3 trial; results may not confirm effectiveness or safety. Side effects are possible, and the drug may not work for everyone.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Clinical Research Site

    Little Rock, Arkansas, 72211, United States

  • Clinical Research Site

    Bellflower, California, 90706, United States

  • Clinical Research Site

    Encino, California, 91316, United States

  • Clinical Research Site

    Lemon Grove, California, 91945, United States

  • Clinical Research Site

    Los Angeles, California, 90015, United States

  • Clinical Research Site

    Montclair, California, 91763, United States

  • Clinical Research Site

    Oceanside, California, 92056, United States

  • Clinical Research Site

    Redlands, California, 92374, United States

  • Clinical Research Site

    Riverside, California, 92506, United States

  • Clinical Research Site

    Sherman Oaks, California, 91403, United States

  • Clinical Research Site

    Torrance, California, 90501, United States

  • Clinical Research Site

    Upland, California, 91786, United States

  • Clinical Research Site

    Walnut Creek, California, 94596, United States

  • Clinical Research Site

    Cromwell, Connecticut, 06416, United States

  • Clinical Research Site

    Brandon, Florida, 33511, United States

  • Clinical Research Site

    Hialeah, Florida, 33012, United States

  • Clinical Research Site

    Jacksonville, Florida, 32256, United States

  • Clinical Research Site

    Orlando, Florida, 32801, United States

  • Clinical Research Site

    Orlando, Florida, 32806, United States

  • Clinical Research Site

    Orlando, Florida, 32807, United States

  • Clinical Research Site

    Chicago, Illinois, 60634, United States

  • Clinical Research Site

    Overland Park, Kansas, 66210, United States

  • Clinical Research Site

    New Orleans, Louisiana, 70115, United States

  • Clinical Research Site

    Boston, Massachusetts, 02131, United States

  • Clinical Research Site

    Saint Charles, Missouri, 63304, United States

  • Clinical Research Site

    Las Vegas, Nevada, 89102, United States

  • Clinical Research Site

    Brooklyn, New York, 11235, United States

  • Clinical Research Site

    Rochester, New York, 14609, United States

  • Clinical Research Site

    Staten Island, New York, 10314, United States

  • Clinical Research Site

    Hickory, North Carolina, 28601, United States

  • Clinical Research Site

    Cincinnati, Ohio, 45215, United States

  • Clinical Research Site

    Oklahoma City, Oklahoma, 73116, United States

  • Clinical Research Site

    Media, Pennsylvania, 19063, United States

  • Clinical Research Site

    Philadelphia, Pennsylvania, 19104, United States

  • Clinical Research Site

    Memphis, Tennessee, 38119, United States

  • Clinical Research Site

    Austin, Texas, 78737, United States

  • Clinical Research Site

    Dallas, Texas, 75231, United States

  • Clinical Research Site

    Friendswood, Texas, 77546, United States

  • Clinical Research Site

    Wichita Falls, Texas, 76309, United States

  • Clinical Research Site

    Everett, Washington, 98201, United States