Depressive disorder

This study tests whether a rapid form of brain stimulation, called accelerated intermittent theta-burst stimulation (aiTBS), can relieve depression in people with bipolar II disorder whose depression has not responded to other treatments. Participants receive either real or sham …

This study offers NRX-101, a combination of two drugs, to adults aged 18-65 with treatment-resistant bipolar depression and suicidal thoughts. Participants receive the medication from their own psychiatrist and undergo regular check-ins on mood, suicidal ideation, and side effect…

This study tests whether a lifestyle physical activity program, supported by a Fitbit and phone counseling, can help women with depression who are in alcohol treatment reduce their risk of relapse. Participants are randomly assigned to either receive the full program or just a Fi…

This study tests whether measurement-based care — where therapists regularly track symptoms using questionnaires — adds extra benefit to weekly psychotherapy for adults with depression or anxiety. Participants are randomly assigned to measurement-based care, standard therapy, or …

This study tests a special deep brain stimulation (DBS) device that can both stimulate and record brain activity in people with treatment-resistant depression. Ten participants will have electrodes implanted in a brain region called the subcallosal cingulate. The goal is to ident…

This study tests whether adding the diabetes drug metformin to standard antidepressants helps people with both depression and obesity lose weight and feel better. Researchers will also check if certain gene variants affect how well the combination works. The trial involves 200 ad…

This study tested whether adding a special type of talk therapy (CBASP) to standard smoking cessation treatment helps depressed smokers quit and feel better. About 91 adults with depression who smoked at least 5 cigarettes a day took part. The goal was to see if the combined appr…

This pilot study in Malawi tests whether adding stigma-reduction counseling to standard depression treatment helps people living with HIV. Two hundred adults with HIV and depressive symptoms will receive counseling sessions that challenge myths and build coping skills. Researcher…

This study looks at the long-term safety and effectiveness of an experimental drug called NMRA-335140 for people with major depressive disorder. About 1,000 adults who completed earlier studies of this drug will take it for 52 weeks. Researchers will track side effects and change…

This study tests a nurse-led program that uses home monitoring devices to help older adults with conditions like heart failure, diabetes, and depression manage their health after leaving the hospital. The goal is to improve care coordination and reduce hospital readmissions. Abou…

This study looks at whether giving people with PTSD a personalized mix of gut bacteria (called pharmabiotics) can help their mental health. The researchers will track changes in PTSD symptoms, anxiety, depression, and thinking skills over 14 days. The goal is to see if fixing the…

This Phase 3 study tests the long-term safety and effectiveness of azetukalner, a daily pill, in 400 adults with bipolar I or II depression who previously completed a related study. Participants take the drug for 52 weeks, and researchers track side effects, mood changes, and qua…

This study looks at the long-term safety and effectiveness of azetukalner in adults with major depressive disorder. Participants must have successfully completed a previous phase 3 study of this drug. The goal is to monitor side effects and track changes in depression symptoms ov…

This study tests whether semaglutide, a drug used for diabetes and weight loss, can help people with schizophrenia who are overweight or obese and did not lose weight on metformin. About 92 participants will receive either semaglutide or a placebo. The main goal is to see if sema…

This study looks at whether 10 weeks of regular exercise (on land or in water) can lower blood sugar and blood pressure in people aged 60 and older who have several health conditions like diabetes, high blood pressure, and arthritis. 63 volunteers will be split into two exercise …

This study in India tests two common depression treatments—a talk therapy called the Healthy Activity Program and the antidepressant fluoxetine—in 1,500 adults with moderate to severe depression. The goal is to see which treatment works best for different people and to compare co…

This study is testing a mobile app called Suubi-Mhealth for Ugandan teens aged 14-17 who have both HIV and depression. The app uses cognitive-behavioral therapy (CBT) to help improve mood and make it easier to stick with HIV medication. About 248 teens will take part to see if th…

This early-stage study is testing whether combining standard psychiatric medications (like antidepressants and anti-anxiety drugs) with individual cognitive behavioral therapy can improve symptoms and daily functioning in people with anxiety, depression, PTSD, OCD, bipolar disord…

This pilot study is testing whether adults with serious mental health issues like psychosis, anxiety, or depression can receive hospital-level care in their own homes. Researchers will see how many people are eligible and willing to try this approach. The goal is to offer a safe,…

This study tests whether intensive home-based psychiatric treatment can help children and teens with mental health disorders as an alternative to being in the hospital. Over 3 months, participants receive 3 to 7 home visits per week from a team of doctors, therapists, and other s…

This trial tests a nurse-led health program for women aged 45 to 64 in Hong Kong. The program uses a 5-step approach (ask, advice, assess, assist, arrange) to help women manage conditions like high blood pressure, anxiety, and menopause symptoms. Researchers will compare the prog…

This study tests whether using MRI to guide transcranial magnetic stimulation (TMS) works better than the usual scalp-based method for treating depression. It involves 54 participants, including those with treatment-resistant depression and others with COVID-related distress. The…

This study compares two ways to help people with both substance use and mental health disorders: a full team-based program called MISSION that provides counseling, peer support, and community outreach for 6 months, versus just linking them with a peer specialist. Researchers hope…

This study tests a phone-based care management program for adults with depression, anxiety, or risky drinking. Participants get regular check-ins and support from a mental health technician, while their primary care doctor receives treatment recommendations. The goal is to see if…

This study tests whether a home-based program combining cognitive exercises (like puzzles) with mild brain stimulation can improve thinking and memory in older adults with mild cognitive impairment or late-life depression. About 40 participants will use the program at home with h…

This study tested a new approach for people with severe depression that hasn't improved with other treatments. A small wire was placed on the surface of the brain to send gentle electrical pulses to areas that control mood. The goal was to see if this is safe and could help reduc…

This study tests whether the anti-inflammatory drug celecoxib can help people with a specific type of depression linked to inflammation, called immuno-metabolic depression (IMD). Researchers will give 140 people with IMD either celecoxib or a placebo, in addition to their usual d…

This study tests whether taking a daily probiotic supplement can help people who were recently hospitalized for bipolar depression avoid another episode. 80 adults aged 18-65 will be randomly assigned to receive either the probiotic or a placebo pill for several months. Researche…

This study tests a new approach for people with depression that hasn't responded to medication. It combines an FDA-approved brain stimulation technique called rTMS with digital mindfulness exercises. The goal is to see if this combination can improve both mood and cognitive funct…

This study tests whether taking fecal microbiota transplantation (FMT) pills can improve symptoms of major depressive disorder (MDD) and irritable bowel syndrome (IBS). About 133 adults with MDD, with or without IBS, will either receive FMT or continue their usual treatment. Rese…

This study tests a new way of delivering mental health and addiction services to youth aged 14-17. Instead of standard hospital outpatient care, an integrated team offers rapid access to various services like therapy, peer support, and primary care in a youth-friendly setting. Re…

This study is a long-term follow-up for people with major depressive disorder who already completed a previous trial with CYB003, a drug similar to psilocybin. It will test how safe and effective CYB003 is over time, with optional extra doses. About 468 participants will be monit…

This study tests whether psilocybin, the active ingredient in magic mushrooms, can help people with both major depression and alcohol use disorder. Researchers at Johns Hopkins will give 90 adults either psilocybin or a placebo and track changes in mood and drinking habits. The g…

This study was designed to test whether a program called Lifestyle MIND can help people with serious mental illness (like schizophrenia or bipolar disorder) prevent or manage type 2 diabetes. The program includes group exercise and health classes twice a week for 10 weeks. Howeve…

This study tests whether a special food supplement with added omega-3s and choline can help undernourished pregnant women carry their babies longer and improve their babies' brain development. It also tests a simple talk therapy program to reduce depression during and after pregn…

This study tests whether deep brain stimulation (DBS) can help people with severe depression that hasn't improved with other treatments. Sixteen adults aged 22 to 70 will have electrodes implanted in a brain region called the medial forebrain bundle. The device delivers mild elec…

This study tests a program called Living Healthy for Moms, where doulas provide cognitive behavioral training and heart health coaching to new mothers. The goal is to reduce postpartum depression and lower the risk of heart problems. The trial includes 21 mothers who recently gav…

This study tests an updated version of the BRITE app, called ViraBrite, which sends suicide safety planning materials and coping skills to teens when they are feeling high emotional distress. Twenty teens who have recently attempted suicide or had suicidal thoughts with a plan wi…

This study looks at whether having a trained peer (someone with similar experiences) as a case manager can help people with HIV who also have mental health or substance use problems get the care they need. About 405 adults from an HIV clinic will be randomly assigned to either us…

This study tests different ways to bring mental health treatment into methadone clinics in Ukraine. 1,350 patients from 12 clinics are taking part. Some clinics get extra training and financial rewards to help screen and treat depression. The goal is to see if these strategies im…

This study compares a structured group exercise program called Braining with standard advice to exercise on your own. Over 12 weeks, 208 psychiatric patients will attend up to three clinician-led exercise sessions per week. Researchers will measure physical activity, depressive s…

This study compares two treatments—electroconvulsive therapy (ECT) and intravenous ketamine—for quickly reversing acute suicidal depression in 1,500 adults aged 18 to 90. Participants are randomly assigned to receive either ECT or ketamine twice a week for up to four weeks. The m…

This large study compares four FDA-approved medications for bipolar depression to see which one helps people feel better. Over 2,700 adults with bipolar I or II disorder and current depression will be randomly assigned to one of the drugs. The goal is to find which treatment lead…

This study looks at whether two school-based programs can help 7th graders with depression, anxiety, and behavior problems. About 1440 students and their parents will answer surveys over a year. The programs focus on improving school discipline and providing family support.

This study tests whether very short, AI-made videos (under 2 minutes) can help 180 older adults with sarcopenia (muscle loss) follow diet and exercise advice and reduce depression. Participants watch these nano-learning videos at home. The goal is to see if this simple approach i…

This study tests a new group program called Forging New Paths for adults with serious mental illness who have also been involved with the criminal justice system. The program combines cognitive behavioral therapy with social learning techniques to reduce aggression and help peopl…

This study tests whether choosing depression treatments based on a person's specific symptoms (like anhedonia or anxious distress) works better than the usual trial-and-error method. 150 adults with major depressive disorder will receive either standard care or a treatment matche…

This study explores whether a taste test can serve as a diagnostic tool for depression. Participants with untreated major depressive disorder will take a taste test before and after starting an antidepressant prescribed by their doctor, and again six to eight weeks later. The goa…

This study tests whether a Turkish translation of the Four-Dimensional Symptom Questionnaire (4DSQ) helps Belgian general practitioners who don't speak Turkish better diagnose depression and anxiety in Turkish-speaking patients with language barriers. About 80 patients and their …

This study tests whether a Samsung smartwatch can detect signs of depression by analyzing heart rate, sleep, and step count. About 220 adults with and without depression will wear the watch for 3 months and complete daily mood surveys. The goal is to see if the watch's 'Mindfulne…

This study tests whether an AI tool can help radiologists read brain CT and MRI scans more accurately and quickly. Researchers will compare how well doctors, AI alone, and doctors using AI together can spot abnormalities, urgent findings, and classify diseases. The goal is to red…

This study explores whether eye-tracking technology in a virtual reality headset can help identify schizophrenia, bipolar disorder, and depression. Researchers will compare eye movement patterns of 120 participants (including healthy controls) to find specific markers for each co…

This study is testing whether artificial intelligence can analyze a person's speech to help diagnose mental health conditions like depression, anxiety, autism, and schizophrenia. Researchers will record 500 people speaking and compare the AI's predictions to standard clinical dia…

This study tests a self-guided online program called CATCH-IT, designed to prevent depression in teenagers who are at risk. Researchers are working with 400 teens aged 13-18 across four health systems to find the best way to deliver this program in primary care. The goal is to se…

This study tests two different programs designed to prevent depression in teenagers who are at risk. One program is an online course called CATCH-IT, and the other is an 8-session group program called TEAMS. About 636 teens aged 13-19 with mild depressive symptoms but no current …

This study tests a psychological empowerment program designed to prevent postpartum depression in pregnant women. 92 first-time mothers in Indonesia will take part in 5 group sessions over 3 weeks, focusing on control, confidence, and coping. Researchers will check if the program…

This study tests a 12-week digital group program called IMAGINE to see if it can prevent depression in pregnant people and new mothers who are at higher risk. About 100 participants will either join the online group or receive standard care. Researchers will check depression and …

This study tests whether a health promotion program can prevent anxiety and depression in older Latino adults who are at risk. 240 participants will either join a program with group walks and social sessions led by a community health worker, or attend a healthy lifestyles educati…

This study tests whether virtual prenatal yoga classes can prevent postpartum depression in pregnant women who have a history of depression. About 62 women will be randomly assigned to either take yoga classes or receive standard care. Researchers will track depression symptoms a…

This 7-year study tests whether a combination of mild electrical brain stimulation (tDCS) and computer-based memory exercises can slow mental decline and prevent Alzheimer's dementia. It involves 375 older adults with mild cognitive impairment or depression (both risk factors for…

This study tests whether a digital sleep program (CBT-I) can prevent depression in pregnant people with insomnia. 456 participants will either use the CBT-I app or receive standard sleep hygiene education. Researchers will track who develops depression through one year after birt…

This study tests whether a workshop led by fellow firefighters can help prevent PTSD, depression, anxiety, and alcohol problems in new firefighter recruits. About 480 trainees will take part in either an emotion regulation workshop or a standard education session during their aca…

This study planned to give soft infant carriers to Black pregnant parents through a home visiting program, to see if babywearing could help prevent postpartum depression and increase breastfeeding. The researchers believed that babywearing, a practice common in many cultures, cou…

This study tests whether a 4-5 week online program can prevent postpartum depression in expecting parents who have certain risk factors. About 520 parents will be randomly assigned to the online training or usual care. The program includes lessons and exercises to reduce negative…

This study tests a mobile app called FirstFocus that uses attention training to help first responders in rural areas prevent stress and mental health issues like anxiety and depression. About 80 active first responders aged 18+ with an iPhone will use the app before and after shi…

This study tests a non-invasive device that uses gentle electrical currents to stimulate the right amygdala, a brain area linked to emotion. Fifty adults with major depression will receive either real or sham stimulation for six weeks. Researchers will measure changes in mood, th…

This study looked at whether omega-3 fatty acids can reduce inflammation and improve mood in adults with treatment-resistant depression. Fourteen participants who were already on antidepressants but still depressed were randomly given either omega-3 supplements or a placebo for 1…

This study tests whether a smartphone app called AIM+ can help juvenile justice officers and other professionals who work with youth in the legal system manage chronic stress, anxiety, and burnout. Over 30 days, participants use the app for short guided meditations and videos. Th…

This study tests an 8-week online stress management program for health students in Sfax, Tunisia. The program combines cognitive-behavioral therapy and mindfulness meditation through videos, exercises, and motivational messages. Researchers will measure changes in stress, anxiety…

This study tests whether an accelerated form of transcranial magnetic stimulation (TMS) can safely and effectively reduce depression symptoms in people with major depressive disorder. About 50 participants aged 15 and older will receive the treatment in an open-label design. The …

This study tests an oral medication called MM120 against a placebo in adults with major depressive disorder. The trial has two parts: a 12-week blinded phase followed by a 40-week open-label extension where everyone gets MM120. The main goal is to see if MM120 reduces depression …

This study looks at whether a peer support program is acceptable and helpful for people with mild depression or anxiety who are starting or receiving hormone care. One hundred participants are randomly assigned to either the peer support group or usual care. The program includes …

This study looks at whether Behavioral Activation (BA) therapy can change the habit of repetitive negative thinking (rumination) in people with major depression. Up to 120 adults will receive 12 sessions of BA over 11 weeks. Researchers will measure symptom changes and explore wh…

This study tests whether a simple ear acupressure technique, called auricular point sticking therapy, can reduce anxiety and improve sleep in women undergoing IVF. 178 women aged 20-45 with anxiety or insomnia will either receive standard IVF care or standard care plus ear acupre…

This small study tests a new treatment called TEST for people with depression that hasn't improved with standard treatments. TEST uses a lower electric current than standard electroconvulsive therapy (ECT), aiming to avoid memory and thinking problems. Eight adults aged 25-64 wil…

This early-phase trial tests whether inhaling a low dose of xenon gas can quickly improve depressive symptoms in 20 people with treatment-resistant major depression or bipolar depression. Participants receive either xenon or a placebo gas added to their usual treatment, and resea…

This study tests a new method called Strategic Treatment Assessment for Youth (STAY) designed to help racial and ethnic minority teens with depression or suicidal thoughts stay in therapy. Researchers will compare STAY to standard care in 140 teens aged 12-18 across three communi…

This study tests a behavioral program called SWITCH that teaches people with serious mental illness (like depression, schizophrenia, or bipolar disorder) to set goals, use rewards, and build habits to do more activities outside the home. 52 participants will attend weekly online …

This study tests whether a unique music therapy, based on Traditional Chinese Medicine's five-element theory, can help men with depression and anxiety when added to their usual medication. One hundred male inpatients will receive either standard drugs alone, drugs plus regular mu…

This study tests whether a wearable headband that shines near-infrared light can improve depression and sleep in adults aged 60 and older with major depression. Participants will wear the device for up to 8 weeks, and researchers will track sleep, mood, and daily activity using a…

This study was designed to test whether a group therapy that uses basic communication skills common to all therapies can help people with depression, anxiety, PTSD, and stress. The therapy avoids specific methods like cognitive-behavioral therapy. The trial was withdrawn before a…

This study tests whether adding ketamine tablets to a new antidepressant can reduce depression symptoms faster in adults with major depression. Twelve participants will take four doses of ketamine over one week while starting a standard antidepressant. The goal is to see if sympt…

This study tests a new program called BRIDGES, designed with teens, to help young people with depression become more active at their own pace. The goal is to see if increasing physical activity can reduce depressive symptoms. The study will involve 60 adolescents aged 12-19 who a…

This study aimed to see if a web-based self-help program called Deprexis could help orthopedic patients with major depressive disorder. The plan was to offer the 8-week online program to patients with depression and see if they would use it and if their mood and physical function…

This study tests whether real-time brain scans (fMRI) can help people with depression learn to reduce rumination—repetitive negative thinking. 80 participants will receive either real or sham neurofeedback while in a powerful 7T MRI machine. The goal is to strengthen a specific b…

This study tests whether a digital cognitive behavioral therapy program, supported by telephone coaching, can help reduce depression symptoms in pregnant women. About 634 mothers with mild to moderate depression were randomly assigned to either the guided digital program or stand…

This study tests a 7-session, peer-led self-management program for 234 cancer survivors who recently finished treatment with curative intent. The program aims to reduce anxiety and depression by teaching symptom management skills in a group setting. Participants are from central …

This study planned to see if wearing light therapy glasses could help reduce depression and tiredness in children and teens who had a stem cell transplant. Participants would have used the glasses for about four weeks while their mood and sleep were tracked. However, the study wa…

This study tests whether a new type of group therapy, called Group Cognitive Evolutionary Therapy, can help reduce symptoms of depression and anxiety. Sixty-four adults with mild to severe depression will either receive two full days of therapy or be placed on a waiting list. Res…

This study tests a single online session that teaches a simple coping skill to youth ages 9-17 who are on a waitlist for therapy. The goal is to see if this quick digital tool can help ease symptoms of anxiety, depression, and stress while they wait. About 226 youth and their par…

This study tests a therapy called RETELL that helps people with severe mental illness explore and reshape their life stories. The goal is to improve personal recovery, quality of life, and identity. Twenty adults with conditions like schizophrenia, bipolar disorder, or PTSD will …

This study tests an experimental drug called JNJ-89495120 in 107 adults with major depression. The goal is to see if it can reduce depression symptoms faster than a placebo, with checks as early as day 2 and day 5. Participants take the drug alone (no other antidepressants) and a…

This study looks at whether nicotine patches can safely improve mood and thinking in adults aged 60 and older with depression. Participants who completed a previous blinded trial will wear a patch daily for up to 12 weeks, then taper off. The goal is to see if nicotine helps the …

This pilot study tests a chatbot named SMILEY that teaches coping skills and safe social media practices to marginalized youth (ages 12-18) who experience depression and online victimization. Over 4 weeks, participants interact with the chatbot at their own pace to learn how to m…

This study tests whether nicotine patches can improve cognitive control (like focus and memory) and mood in adults aged 60 and older with depression. Sixty participants will wear either a nicotine or placebo patch daily for 12-15 weeks. Researchers will measure changes in depress…

This pilot study tests whether a brief cognitive behavioral therapy delivered via video conference can help adults with mood disorders who are at high risk for suicide. Forty participants will either receive the video therapy plus usual care, or usual care alone. The study will m…

This study tests an 8-week program called Step-CBT that combines physical activity goals with cognitive behavioral therapy for veterans with COPD who also have depression or anxiety. The program is delivered via video calls to make it accessible. Researchers want to see if it is …

This study tests a short, enhanced cognitive behavioral therapy (E-BCBT) for people hospitalized after a suicide crisis. 30 participants will either receive 5 therapy sessions during their stay or standard care. The goal is to see if this therapy reduces suicide attempts and suic…

This study explores whether individualized transcranial magnetic stimulation (TMS) can improve symptoms in adults with irritable bowel syndrome (IBS). Participants receive 10 TMS sessions over two weeks, with brain scans and stool tests before and after to understand how the trea…

This Phase 3 study tests whether a single 25 mg dose of synthetic psilocybin can reduce depression symptoms in 238 adults with major depressive disorder. Participants receive either psilocybin or a placebo, and their depression severity is measured over 43 days. The trial also lo…

This study tests whether a device that sends mild electrical pulses to facial muscles can help treat major depression. Twenty adults with depression will use the device at home for 45 minutes daily over four weeks. The main goal is to see if the approach is feasible and safe, wit…

This study tests a program called Omnis Salutis for recent veterans with PTSD, depression, anxiety, or substance use disorders. The program teaches veterans to identify their health goals and communicate them to doctors and family. Researchers want to see if it improves social an…

This study tests whether a smartphone app can help adults who are hospitalized for depression or suicidal thoughts. After leaving the hospital, participants use the app for 28 days to practice skills that encourage positive activities. The goal is to see if the app is easy to use…

This study tests whether a single injection of ketamine can quickly reduce suicidal thoughts in people with depression who come to the emergency room. About 90 participants will receive either ketamine or a sedative (midazolam) and be monitored for 24 hours. The trial is currentl…

This study tests whether adding a new drug called ABX-002 to current treatments can improve depression symptoms in adults with bipolar disorder. About 30 people with bipolar depression will take the drug for 6 weeks, and some will have brain scans to see how it affects brain chem…

This study is an extension of an earlier trial, testing the safety and tolerability of SPT-300 in 360 adults with major depressive disorder, with or without anxious distress. Participants who completed the prior study will receive SPT-300 for 6 weeks. The goal is to monitor side …

This study tests a digital cognitive behavioral therapy program (SilverCloud) for Spanish-speaking adults with depression or anxiety. 426 participants will either use the program on their own or get extra support from a peer coach via phone or messaging. The goal is to see if add…

This pilot study tests whether an 8-week mindfulness program (MBSR) can reduce anxiety, depression, and stress in people with COPD who are already in pulmonary rehab. About 44 participants will be followed for 12 months. The goal is to see if this mind-body approach improves emot…

This study looks at whether an 8-week yoga program during pregnancy can lower the risk of postpartum depression and strengthen the bond between mother and baby. It involves 60 first-time mothers who are 26-28 weeks pregnant. Participants will either take yoga classes or receive s…

This study tests whether a daily oral drug called SP-624 can safely reduce depression symptoms in adults with major depressive disorder. About 456 participants will receive either SP-624 or a placebo for several weeks. The main goal is to see if SP-624 leads to a greater improvem…

This study looks at how a fast form of brain stimulation called iTBS affects the brains of 22 adults with major depression. Participants receive both real and fake stimulation in a blinded setup, followed by 6 weeks of daily treatment. The goal is to understand how iTBS changes b…

This study tests whether a physical activity program can help pregnant people with symptoms of depression or anxiety feel better. 88 participants will be given a step goal and wear an activity tracker. The program includes weekly reminders and motivational coaching every two week…

This study tests a new device that uses mild electrical currents to stimulate the brain in people with major depression. The device adjusts the stimulation in real time based on brain activity. The goal is to see if the device works correctly and if it can help reduce depression …

This study aimed to see if nitrous oxide (laughing gas) could help people with major depression, especially those who hadn't improved with other treatments. Participants would have received four weekly sessions of the gas or a placebo. However, the study was withdrawn before any …

This study tests a mindfulness program (called GEM) delivered through an app and weekly group video calls. It aims to see if young adults (ages 18-24) who have faced early life hardships find the program helpful and easy to use. The study also checks if the program reduces sympto…

This study looks at whether giving vitamin D supplements to women with depression and low vitamin D levels can change their brain waves. Researchers will measure brain activity using a non-invasive EEG scan before and after supplementation. The trial includes 34 women aged 20-40 …

This study tests an online cognitive behavioral therapy (CBT) program for university students with mild depression or anxiety. Two hundred students who previously took a mental health survey will receive a tailored internet treatment. The goal is to see if this e-health approach …

This study looks at whether a low dose of esketamine, given during and after weight-loss surgery, can help reduce depression in patients who were already depressed before surgery. Forty adults with a BMI over 35 and a Hamilton Depression score of 7 or higher are taking part. The …

This study tests whether listening to specific sound frequencies for just 9 minutes a week can improve mental health. 110 adults with mild anxiety, stress, or depression will either sit in a special sound chamber or use headphones. The goal is to see if this simple, drug-free app…

This study tests whether a non-invasive magnetic brain stimulation technique, called rTMS, can help ease depression in people with Parkinson's disease. Fifty adults with mild to moderate depression will be randomly assigned to receive either real rTMS or a sham (fake) treatment f…

This study tests whether giving different numbers of daily brain stimulation sessions (rTMS) can safely improve symptoms in people with moderate to severe depression that hasn't responded to other treatments. One hundred adults will receive 4, 6, 8, or 10 sessions per day for 5 d…

This pilot study tests whether a wearable device that delivers intermittent white light at 60 Hz can safely help people with moderate to severe depression. Thirty adults on stable antidepressant medication will wear the goggles for 30 minutes daily over two weeks. The main goal i…

This study aims to develop and test a shortened version of Mindfulness-Based Cognitive Therapy (MBCT) to improve mood in older African American/Black women who have had breast cancer and now have mild to moderate depression. About 23 participants will attend group sessions and re…

This study looks at whether cancer patients can use a self-guided meditation program at home to reduce anxiety and depression. About 35 patients will try techniques like deep breathing or gentle movement for two weeks. The goal is to see if this simple, low-cost approach is pract…

This study tests whether a prenatal yoga app called Down Dog can help pregnant African American women feel better mentally and physically. Over 12 weeks, 50 first-time mothers will use the app at home, wear a fitness tracker, and complete surveys. The goal is to see if the app is…

This study tests whether an internet-based self-help program called VIVIM can help university students with anxiety and depression. About 108 students will be randomly assigned to use VIVIM or receive usual support from their university counseling service. They will fill out ques…

This study tests whether up to two doses of psilocybin (the active ingredient in magic mushrooms) can safely reduce depression in adults who have both cancer and major depressive disorder. About 56 participants will receive either psilocybin or a placebo in a first session, and t…

This small pilot study tests whether Imagery Rescripting, a therapy that helps people change negative mental images, can reduce depression and negative beliefs. Ten adults with major depressive disorder will receive weekly sessions after a waiting period. The study tracks depress…

This study tests a stepped care approach to reduce depressive symptoms in 600 adolescents aged 13-15 from 40 schools in Rawalpindi, Pakistan. First, all students receive a universal intervention delivered by non-specialists. Those who still have symptoms after 3 months get extra …

This study tests a program that combines family group sessions with a virtual peer mentoring program for US-born teens (ages 14-17) whose parents resettled as refugees. The goal is to reduce symptoms of PTSD, depression, anxiety, and behavior problems caused by intergenerational …

This small study tests whether group drumming sessions can improve emotional well-being for parents of autistic children. Ten parents will take part in drumming groups and report changes in anxiety, depression, and feelings of belonging. The goal is to see if making music togethe…

This pilot study tests whether a type of brain stimulation called accelerated continuous theta-burst stimulation (acTBS) can reduce suicidal thoughts in people hospitalized for depression. Forty inpatients will receive either real or sham (fake) stimulation up to 5 times a day fo…

This study tests a brief digital mental health program for people on waiting lists for psychological treatment. About 80 participants will be randomly assigned to one of four groups: a short program (30-40 minutes), a longer version, or control conditions. The main goal is to see…

This study aimed to see if transcranial magnetic stimulation (TMS) combined with talk therapy could help teens aged 13–17 whose depression didn't improve with standard treatments. Participants would have daily TMS sessions for two weeks and weekly therapy. However, the study was …

This pilot study tests whether using a soft baby carrier for extra physical contact helps mothers with prenatal anxiety or depression feel more connected to their baby. Forty moms in Montreal will either use the carrier or be on a waitlist. Researchers will measure bonding, brain…

This early-phase study looks at whether Emotional Freedom Techniques (EFT) — a practice that combines tapping on acupressure points with counseling — can reduce anxiety, depression, pain, and insomnia in people with cholangiocarcinoma, a rare and aggressive bile duct cancer. Four…

This study tests a 12-session group therapy program (G-BCBT) for active duty military personnel who have recent suicidal thoughts or a recent suicide attempt. The therapy teaches emotion regulation, cognitive flexibility, and relapse prevention skills. Researchers will measure ch…

This study tests whether an online self-compassion program can help fathers of infants who are feeling anxious or depressed. Forty fathers in Hong Kong will take part in five weekly online sessions. The goal is to see if the program is practical and helpful for improving their me…

This study tests whether combining a mild electrical brain stimulation (tDCS) with virtual reality meditation can help ease anxiety. 52 adults with generalized anxiety disorder or related conditions will receive 12 sessions over two weeks. Researchers will measure anxiety levels …

This study looks at whether music therapy can help children and teenagers with mood disorders who also hurt themselves (called non-suicidal self-injury, or NSSI). About 54 participants will take part, and researchers will use questionnaires, brain scans, and electrical brain acti…

This study looks at whether using a mindfulness app on a smartphone for 8 weeks can improve mental health in Korean immigrants aged 60 and older. Participants use the app for about 10-15 minutes daily and have weekly check-ins. The goal is to see if the app is easy to use and hel…

This study compares two brain stimulation treatments—electroconvulsive therapy (ECT) and magnetic seizure therapy (MST)—for people with severe depression that hasn't improved with standard medications. About 100 adults with major depression or bipolar depression will receive one …

This study tests whether using a virtual reality (VR) relaxation session can lower anxiety in people about to receive electroconvulsive therapy (ECT). Twenty adults already receiving ECT for depression will try VR relaxation, breathing exercises, or no extra relaxation. Researche…

This study tests whether Compound Ciwujia Granules, a traditional Chinese herbal medicine, can help reduce depression symptoms in people with a specific syndrome (heart-spleen deficiency). About 60 adults with major depressive disorder will take either the granules or a placebo t…

This study tests whether short, computer-based cognitive training sessions can enhance or extend the rapid antidepressant effects of ketamine or esketamine. Researchers will enroll 600 adults with depression who are already receiving ketamine treatment. Participants will do eithe…

This study tests if a therapy called FIRST, which uses five key principles to help youth manage negative emotions, works better than standard therapy. About 212 youth aged 7 to 15 with anxiety, depression, trauma, or behavior problems will take part. The goal is to see if FIRST i…

This pilot study tests whether two smartphone apps can help current smokers quit. 24 participants will use either the KickAsh app (to track mood and activity) or the Breathe2Relax app (for relaxation). Researchers will check if the apps improve mood, increase activity, and lead t…

This study tests whether bright light therapy can help ease depression symptoms in adults aged 60 and older who are hospitalized for unipolar depression. Twenty participants will receive either active light therapy or a dim placebo light. The main goals are to see if the treatmen…

This study tests a community-based program called CRISOL Mente to help Latinos in the Philadelphia area with depression, anxiety, or PTSD. The program uses outreach workers to connect people to mental health care and support. Researchers will measure if symptoms improve after six…

This study tests a brief behavioral therapy program delivered via telehealth (STEP-UP) for children and teens aged 8 to 16 with anxiety or depression. Participants are recruited from community health centers and randomly assigned to either STEP-UP or a referral to local mental he…

This study tests a voice-assisted program using Amazon Alexa to help older adults (65+) with depression and their caregivers. Participants use the program for goal setting, reminders, and other mental health support over 12 weeks. Some participants also receive a guide to help th…

This study aims to help mothers of babies in intensive care cope with depression, anxiety, and stress while also addressing basic needs like food and housing. About 200 caregivers of infants up to 6 months old will receive emotional support and referrals to community resources. T…

This study tests an experimental oral medication, NMRA-335140, against a placebo in 332 adults with major depressive disorder. The goal is to see if the drug reduces depression symptoms over 6 weeks. Participants are randomly assigned to receive either the drug or a placebo, and …

This study compares a text message-based mental health and substance use screening program (Listening to Women & Pregnant and Postpartum People) to standard in-person screening. Over 10,000 pregnant and postpartum people will participate. The goal is to see if the text-based appr…

This study tests an experimental oral medication, NMRA-335140, against a placebo in 332 adults with major depressive disorder. Over 6 weeks, researchers measure changes in depression symptoms using standard rating scales. The goal is to see if the drug can safely reduce depressio…

This study tests whether virtual reality (VR) therapy can reduce depressive symptoms in pregnant women who are hospitalized for at least three weeks. Participants will either receive VR-based behavioral activation therapy or standard social work consultations. The goal is to see …

This study aimed to compare online group cognitive behavioral therapy (CBT) with in-person group CBT for adults with major depression. The goal was to see if online therapy is just as effective and more cost-effective. However, the trial was withdrawn before enrolling any partici…

This study tests an accelerated version of a brain stimulation treatment called TMS for people with depression and anxiety. Researchers want to find the best dose to reduce symptoms. About 70 adults will take part, and the study measures changes in mood using standard questionnai…

This pilot study tests a specific type of drama therapy for people who have both a mental health condition (like depression or bipolar disorder) and a substance use disorder. Ten participants will attend weekly group drama therapy sessions for 12 weeks, then put on a performance.…

This pilot study planned to test a group therapy program called Problem Management Plus (PM+), developed by the WHO, with or without a one-time cash payment, for adults with depression, anxiety, or stress in Ethiopia. The goal was to see if combining psychotherapy with financial …

This study tests whether a 12-week physical activity program can reduce depressive symptoms in adults with major depressive disorder. 110 participants are split into two groups: one continues antidepressant treatment alone, the other adds a tailored exercise routine. Researchers …

This pilot study tests a therapy called Positive Affect Treatment (PAT) for Spanish-speaking adults with depression, anxiety, and low positive affect (a lack of joy or interest). Twelve participants will attend 15 therapy sessions over about 4 months, focusing on pleasant activit…

This study looks at whether a special type of massage therapy, designed to be sensitive to trauma and different cultures, can help refugees and asylum seekers who survived torture or war. About 50 people will either get their usual care plus this massage, or just usual care. The …

This pilot study tests whether a personalized form of transcranial magnetic stimulation (TMS) is feasible and safe for people with severe major depressive disorder who haven't improved with multiple medications or therapy. Ten participants will receive up to 30 TMS sessions over …

This pilot study tests whether a 4-month program that encourages people from underserved communities to engage in rewarding community activities can improve depression symptoms, physical activity, and weight. The study involves 102 adults with elevated depressive symptoms and at …

This study tests whether watching a virtual reality (VR) video of an electroconvulsive therapy (ECT) session can reduce anxiety and improve knowledge about the procedure. About 64 adults about to have ECT for the first time will be randomly assigned to either a VR education sessi…

This pilot study tests a six-session psychological intervention for depression in 50 young people aged 15-24 in Zimbabwe. The therapy, delivered by trained lay counsellors, includes education about depression, activity scheduling, and problem-solving. The main goal is to see if t…

This study explores whether low intensity focused ultrasound (LIFU) can safely change brain activity linked to depression and anxiety in 25 veterans. Participants receive LIFU during MRI scans, and researchers monitor for side effects and brain changes. The goal is to see if this…

This pilot study tests a brief psychological intervention called Y-MIND for depression in older adolescents (ages 15-18) in senior high schools in Ghana. The intervention is delivered by trained school guidance counselors and includes education about depression, behavioral activa…

This phase 2 trial tests whether adding magnesium to a standard SSRI antidepressant works better than the SSRI alone for adults with major depressive disorder. Fifty participants will be randomly assigned to receive either the combination or just the SSRI. The main goal is to see…

This study tests whether sitting under a bright light for 30 minutes each day for six weeks can improve mood in people with bipolar depression who also tend to be evening types. Seventy adults will be randomly assigned to either the bright light or a placebo device. The goal is t…

This study tests whether adding a group therapy called Kiesler Circle Training (KCT) to standard cognitive behavioral therapy (CBT) helps people with depression or anxiety improve their interpersonal skills. About 156 participants will receive either CBT alone or CBT plus KCT. Th…

This study looks at whether listening to Surah Al-Inshirah (a chapter from the Quran) in the first two days after a C-section can improve a mother's spiritual well-being, lower depression risk, and strengthen her bond with her newborn. About 172 first-time Muslim mothers who had …

This study aimed to see if a single 45-minute dose of inhaled nitrous oxide (laughing gas) could quickly reduce suicidal thoughts and depression in people visiting the emergency department. It was designed for adults aged 18-65 with major depressive disorder who were actively sui…

This study looks at whether unlicensed professionals can successfully provide cognitive behavioral therapy (CBT) to patients in a general hospital. It includes 250 adults with conditions like anxiety, depression, OCD, and PTSD. The goal is to see if this approach improves psychol…

This study tests whether a non-invasive brain stimulation technique called tDCS can improve depression and other non-motor symptoms in people with Parkinson's disease. About 80 participants will receive either real or fake (sham) stimulation for 30 minutes over 10 sessions. The g…

This study tests a new medicine called ONO-1110 in 100 Japanese adults with major depressive disorder. Participants receive either the drug or a placebo for 8 weeks. The main goal is to see if the drug reduces depression symptoms more than placebo.

This study tests whether a 5-week virtual reality program that teaches positive thinking skills can help reduce depression and improve quality of life in people on hemodialysis. Sixty-one adults with end-stage kidney disease and mild-to-moderate depressive symptoms will either re…

This study tests a device called Cereset that plays tones to mirror your brainwaves, aiming to reduce stress, anxiety, insomnia, and depression. About 40 nurses from one hospital unit will use the device. The goal is to see if it improves their well-being and job performance.

This study tests whether a mobile app called PTSD Coach, with or without brief clinician support, can reduce PTSD, anxiety, depression, and sleep problems in World Trade Center responders living in Florida. About 120 English- or Spanish-speaking responders will be randomly assign…

This study tests two non-invasive brain stimulation methods to help people with major depression who haven't gotten better with medication. Ninety adults will receive either standard or deep brain stimulation daily for four weeks. Researchers will check if the deep method reduces…

This early-stage study is testing a smartphone app called NEAT-O that provides cognitive behavioral therapy (CBT) to adults with opioid use disorder who also have anxiety or depression. The goal is to see if the app is easy to use and acceptable to patients. If successful, it wil…

This pilot study tested whether kava, a herbal supplement, could safely reduce anxiety and stress in 43 cancer survivors who had completed treatment. Participants took either kava or a placebo for 14 days, then switched after a washout period. The trial is currently suspended, an…

This study tests a new way of doing electroconvulsive therapy (ECT) for people with treatment-resistant depression. The goal is to target the brain more precisely to reduce side effects like memory loss while still helping with depression. Twenty participants will receive the new…

This study tests whether a type of brain stimulation called rTMS can reduce depression in people with autism. Twenty-four participants aged 13 to 26 will receive either real or sham (fake) stimulation to see if it helps. The goal is to find a new way to treat depression that hasn…

This trial tests whether an AI-based management platform, called 'Zhiliao Doctor,' can reduce anxiety and depression in 300 breast cancer patients taking CDK4/6 inhibitors at home. Participants are randomly assigned to standard care, the AI platform, or personalized follow-up cal…

This study tests whether a virtual, community-based program combining music and mindfulness can help reduce stress, anxiety, and depression in people of African descent. About 300 participants aged 16 and older will take part. The goal is to see if these culturally relevant activ…

This study looks at whether moderate-to-vigorous aerobic exercise, called Braining, can help people with bipolar depression recover faster and prevent future depressive episodes. Fifty-four participants will be split into three groups: one doing supervised aerobic exercise three …

This study looks at whether following an anti-inflammatory diet for 4 months can improve symptoms of anxiety and depression in 60 adults. Participants will either follow the special diet or their usual eating habits. The study also uses artificial intelligence to analyze speech a…

This study tests whether adding group mindfulness-based therapy to usual treatment helps people with serious mental illnesses like schizophrenia, bipolar disorder, or major depression. Researchers will randomly assign 160 patients to either usual care alone or usual care plus min…

This study tests a program that combines mood management with health and wellness coaching to help pregnant smokers who are depressed quit smoking and stay smoke-free after their baby is born. About 26 participants will take part during pregnancy and after birth. The goal is to s…

This study tests whether 8 weeks of acceptance and commitment therapy (ACT) delivered via Zoom can help reduce depression in people with spinal cord injuries. 140 participants with mild or worse depressive symptoms will be randomly assigned to either ACT or a wait-list that conti…

This early study tests whether adding Adderall XR (a stimulant) to repetitive transcranial magnetic stimulation (rTMS) can improve depression symptoms more than rTMS plus a placebo. Thirty adults with treatment-resistant major depressive disorder will take either Adderall or a su…

This study tests a 15-session creative writing program called REWRITALIZE for people with serious mental illnesses like schizophrenia, bipolar disorder, or severe depression. About 300 adults will either join the writing groups plus their usual care, or stay on a waiting list wit…

This study tests a group therapy called Awareness, Courage, and Love (ACL) for older adults with psychiatric disorders who feel lonely. The therapy focuses on mindfulness, sharing feelings, and building connections. Researchers want to see if the program is practical and helpful …

This study tests whether a faster version of transcranial magnetic stimulation (TMS) can safely treat major depressive disorder. Instead of the usual 30 sessions over six weeks, participants receive three 19-minute sessions in a single day. The trial includes 37 adults aged 22-85…

This early-stage study tests a new tablet called LY03021 in 98 healthy adults aged 18 to 45. The main goal is to check safety and how the body processes the drug. It is a first step before testing the drug in people with depression.

This study tests whether a 10-week online group talking therapy (CBT) can help mothers and birthing parents with postpartum depression or anxiety. About 48 participants in Ontario will be randomly assigned to receive the therapy plus usual care, or usual care alone. The goal is t…

This study aimed to see if a mild electrical current applied to the scalp (transcranial direct current stimulation) could help people with severe depression that didn't improve after at least five treatments or electroconvulsive therapy. Participants would have received 30 sessio…

This study tests whether electroacupuncture (a type of acupuncture with mild electrical pulses) can improve memory and mood in adults aged 60-80 who have subjective cognitive decline (worries about memory) and depression. Eighty-six participants will receive either real or sham e…

This Mayo Clinic study tests whether reducing overall smartphone use and avoiding social media apps like Facebook, Instagram, and TikTok can lower anxiety symptoms in adults. One hundred participants with mild anxiety will be asked to change their phone habits, and their anxiety …

This study tests whether a smartphone app called MENTINA can help people with depression or mental distress better manage their symptoms. About 660 adults from Denmark, Germany, and Spain will use the app daily to track mood, sleep, and activity, and receive personalized tips. Th…

This study tests whether adding a computer-based cognitive training program can improve depression relief for people already receiving esketamine treatment. Researchers will enroll up to 40 adults aged 18-80 at the University of Pittsburgh. The goal is to see if this approach can…

This small pilot study tested whether low-intensity focused ultrasound can safely ease symptoms in people with treatment-resistant depression. The device targets a brain region linked to mood. Only 1 person was enrolled, and the trial is currently suspended, so results are very l…

This study tests whether taking postbiotics (a dietary supplement) for 8 weeks can reduce depressive symptoms and improve mood in Korean adults aged 19-39 with mild to moderate mood issues. Fifty-two participants will receive either postbiotics or a placebo, and their mood will b…

This study is testing whether CreNeuriS CNS herbal nutrition capsules can safely reduce symptoms of mild depression and anxiety. Thirty adults aged 18 to 65 with both conditions will take the capsules for six weeks. Researchers will measure changes using a standard depression rat…

This study tests a new way to deliver an FDA-approved treatment called TMS (transcranial magnetic stimulation) for depression in adults aged 60 to 79. Researchers use fMRI brain scans to personalize the treatment target. The goal is to improve depression symptoms and brain connec…

This study tests a 7-week group physical activity program called Confident, Active and Happy Youth (CAHY) for young people aged 8-17 with anxiety or depression. The program includes fun, non-competitive activities led by a therapist. Researchers want to see if it improves mood an…

This study is testing a device called SAINT® that delivers a special type of brain stimulation (accelerated TMS) to treat major depression. It involves 1000 adults who haven't gotten enough relief from standard antidepressants. Participants get 10 treatments each day for 5 days, …

This study tests whether inhaling nitrous oxide (laughing gas) can quickly reduce suicidal thoughts in people hospitalized for depression. Fifty adults with major depression and active suicidal ideas will receive either nitrous oxide or a placebo gas, plus their usual treatment. …

This study planned to test whether virtual reality-based guided mindfulness meditation could help adults with anxiety, depression, stress, or pain feel better. Researchers wanted to see if using VR meditation was practical and if it improved mood and pain scores. However, the stu…

This study tests whether pairing meditation with a brain stimulation technique called rTMS can better treat depression. rTMS is already FDA-approved but only works for about 15-30% of patients. The researchers hope that adding a focus on internal attention (like breathing) during…

This study compares two non-invasive devices that stimulate the vagus nerve—one placed on the neck, the other on the ear—to see which better reduces physical discomfort and health-related anxiety in people with somatic symptom disorder. Sixty participants will try both devices in…

This study tests a short, 5-session counseling program called LEAD for fathers in Kenya who have depression and drink alcohol. About 102 fathers will be randomly assigned to the program or a waitlist. The goal is to see if the program improves fathers' mental health, parenting, a…

This study compares two non-drug therapies—mindfulness-based therapy and cognitive-behavioral therapy—for pregnant women who have both insomnia and depression. About 100 women in their second trimester will participate to see which approach better reduces sleep problems and depre…

This study tests a quick, non-invasive brain stimulation method called accelerated intermittent theta-burst stimulation (aiTBS) to see if it can improve mood in people with borderline personality disorder (BPD) who are also experiencing a major depressive episode. About 45 adults…

This study tests whether a 9-week online group talk therapy program, co-led by a public health nurse and a mother who has recovered from postpartum depression, can reduce depression symptoms in new mothers. 170 mothers in Ontario with an infant under 12 months and signs of depres…

This study tests whether a smartphone app based on cognitive behavioral therapy (CBT) can help adults who are already taking antidepressants feel better. 150 participants in Sweden will use the app for 9 weeks, with extra online materials and therapist support available. The goal…

This study tests whether taking D-cycloserine (a drug originally used for TB) before a non-invasive brain stimulation therapy called iTBS can improve depression symptoms more than the stimulation alone. About 180 adults with treatment-resistant depression will receive daily iTBS …

This study tests whether a non-invasive brain stimulation method called theta burst stimulation can help people with depression who refuse medication. 72 participants will either start treatment right away or wait four weeks. The goal is to see if the stimulation alone can reduce…

This small pilot study tests whether deep brain stimulation (DBS) aimed at a specific brain region called the lateral habenula can safely reduce symptoms in 6 adults with severe, treatment-resistant depression. Participants have either major depressive disorder or bipolar I and h…

This study tests whether a robot that can be personalized by older adults helps reduce loneliness and depression. 90 people aged 65+ in a care home will either get a personalized robot, a standard robot, or usual care. The goal is to see if a co-designed robot buddy improves well…

This small pilot study tests whether psilocybin, the active ingredient in magic mushrooms, can change brain connections to improve depression. 18 adults with major depression who didn't get better with standard treatments will receive psilocybin. Researchers will measure brain ac…

This study looks at whether two Akashic Records sessions can improve mental health in adults who have felt stressed, anxious, or down in the past year. Participants will attend private video sessions with a therapist and complete surveys about their mood and resilience. The goal …

This study tests a short, acceptance-based therapy (ABBT) to help LGBTQ+ adults with mild anxiety or depression worsened by the COVID-19 pandemic. 240 participants will either receive the therapy or standard care. The goal is to see if ABBT can reduce symptoms and improve social …

This study tests a smartphone app called MS CATCH that lets people with multiple sclerosis regularly report their mood to their neurologist. The goal is to improve how doctors screen and treat depression in MS. About 100 adults with MS and mild-to-moderate depression are taking p…

This study tests a teaching method called Cooperative Learning, where teens work in small groups with the help of technology. The goal is to see if this approach can reduce anxiety, depression, and suicidal thoughts in 1,200 students. The method is designed to be easy for schools…

This study tests a type of brain stimulation called theta-burst rTMS in 54 adults with depression that hasn't responded to other treatments. The goal is to see if it eases depression and thinking problems, and to use brain scans to predict who will benefit. Participants receive d…

This study tests whether a single dose of ketamine, given while patients are sedated, can reduce chronic pain and depression symptoms. Forty adults with both conditions will receive either ketamine or a placebo (saline) during sedation with propofol. Researchers will track pain a…

This study tests whether a type of brain stimulation called intermittent theta burst stimulation (iTBS) can help people with major depression who are already on medication but still have symptoms. About 30 adults will receive either real or sham stimulation to see if it improves …

This early-phase study tests whether giving a single intravenous dose of the antidepressant citalopram together with 10 sessions of theta burst stimulation (a form of transcranial magnetic stimulation) can quickly improve depression symptoms. Thirty adults with major depressive d…

This study tests a new type of brain stimulation for people with treatment-resistant depression. Ten participants will receive both real and sham stimulation in a random order, with a break in between. The goal is to see if this personalized, closed-loop approach can safely impro…

This study tests whether qigong, a gentle mind-body practice, can improve mood and thinking in people aged 65 and older with depression. Sixty participants will do either qigong or regular exercise for 8 weeks. Researchers will measure changes in brain activity and cognitive skil…

This pilot study explores whether laughter yoga can reduce depression and anxiety in children with autism spectrum disorder (ages 8–12) and lower parenting stress for their parents. 66 families will either take part in laughter yoga sessions or be placed on a waiting list. The st…

This study looks at whether taking vitamin D supplements for six months can improve depression symptoms. About 319 adults with depression are getting either a low or high dose of vitamin D daily, while continuing their usual treatment. Researchers will track their mood and health…

This program provides early access to ZULRESSO (brexanolone) for adult women with postpartum depression before the drug is widely available. Eligible women receive a one-time injection under medical supervision. The goal is to help ease severe depression symptoms quickly.

This study tests whether a smartphone app called 'Serene Motherhood' can reduce symptoms of postpartum depression in new mothers who are at high risk. About 79 women in Jordan with elevated depression scores will use the app or receive standard care. The goal is to see if the app…

This study tests whether a mobile app called OkeyMind can reduce social anxiety and depression in young people aged 15 to 24. The app provides psychoeducation and guided meditation over one month. 180 participants will be randomly assigned to use the app immediately or wait three…

This study looks at whether weekly group drumming for 8 weeks can improve the health of people aged 60 and older living in the community. Researchers will measure changes in quality of life, depression, sleep, and blood pressure. 300 participants will take part, and the goal is t…

This study investigates whether changes in brain chemicals (GABA and glutamate) can predict who will respond to ketamine for treatment-resistant depression. Researchers will give two intravenous ketamine infusions to 18 adults and measure chemical levels in the brain and blood. T…

This study tracks 80 adults with different smell disorders (like total loss, partial loss, or distorted smell) plus healthy volunteers over one year. Researchers use brain scans, smell tests, and questionnaires to see how the brain changes and how smell loss impacts mood and dail…

This Phase 1 study aims to understand how the body processes ketamine after a cesarean delivery, and whether it can help with postpartum depression and pain. Fifty participants will receive a low-dose ketamine infusion, and researchers will measure drug levels and side effects. T…

This study investigates how the brain's emotion network works by recording brain activity directly from the surface of the brain in people with epilepsy who are already undergoing surgery for seizure monitoring. Participants watch short video clips designed to trigger emotions li…

This study looks at how vagus nerve stimulation (VNS) affects the nervous system, heart, immune system, and metabolism in people who already have a VNS device for epilepsy or depression. Researchers will measure things like nerve activity, blood pressure, and heart rate during di…

This long-running study follows nearly 100,000 French women, mostly teachers, since 1990 to understand what factors influence their risk of cancer, heart disease, diabetes, and other major illnesses. Participants fill out questionnaires every few years about their lifestyle, medi…

This study aims to find genes that may increase the risk of developing bipolar disorder. Researchers are collecting DNA and health information from 4,185 adults to understand the genetic causes of the condition. The goal is to improve diagnosis and treatment in the future, but th…

This study follows 2,500 people aged 10 and older with depression or bipolar depression over 10 years. Researchers collect data on symptoms, brain scans, genetics, and lifestyle to find patterns that predict how someone will respond to different treatments. No experimental drugs …

This study tests a 10-week program called 'Grow to Recovery' for people with mental illness. The program is co-led by a peer (someone who also has a mental illness) and a professional. Researchers want to see if it helps participants feel more hopeful and capable. 138 people are …

This study explores how anxiety contributes to treatment-resistant depression. Researchers will follow 37 adults with depression to see if anxiety levels can predict who will have a harder time recovering. The goal is to better identify at-risk patients and develop more targeted …

This study looks at whether adding aripiprazole to the antidepressant escitalopram can reduce pathological rumination—repetitive, intrusive negative thoughts—in people with major depressive disorder. 108 participants will receive either escitalopram alone or escitalopram plus ari…

This study uses PET and MRI scans to measure brain cell connections in people with major depression or PTSD. Researchers will give ketamine to see if it can reverse synaptic loss linked to these conditions. The goal is to understand brain changes, not to provide treatment. About …

This study looks at sleep patterns in 94 adults with major depressive disorder, comparing those with moderate-to-severe insomnia to those with mild or no insomnia. Participants wear a headband at home that records brain activity during sleep and also fill out sleep diaries and qu…

This study looks at how the severity of depression relates to erectile dysfunction and premature ejaculation in 100 married men aged 25–60 in the Sohag region of Egypt. Participants are clinically diagnosed with depression and sexually active. Researchers will use standard questi…

This study adapts an existing stigma-reduction program specifically for pregnant and postpartum women living with HIV in Ghana. Researchers will interview 30 women and 20 providers to understand their experiences, then work with stakeholders to tailor the program. Finally, 90 pre…

This study adapts a 'Health at Every Size' program for pregnant people with a BMI over 30. Ten first-time mothers will attend group sessions on nutrition, movement, and self-advocacy. The goal is to see if the program is acceptable and helpful in reducing weight stigma and improv…

This 10-year study follows 1,500 young people aged 10-24 to learn what makes some more resilient to depression and anxiety than others. Researchers will track lifestyle, brain scans, and mental health over time. No treatments or interventions are given—the goal is simply to obser…

This study follows 100 teens aged 13-18 who are already enrolled in a depression registry. For 30 days, they report their feelings and social media use twice daily via a phone app, then complete monthly surveys for 6 months. The goal is to understand how social media relates to d…

This study follows 300 Hispanic and Latino caregivers of relatives with memory problems or dementia. Participants complete daily surveys for three weeks at a time, plus follow-ups at six and twelve months, to track how their mood and stress change day-to-day. The goal is to ident…

This study tests a web-based tool called gp-multitool.de that helps general practitioners follow guidelines for older patients with multiple chronic conditions. About 659 patients from GP practices in Germany are taking part. The tool lets patients fill out questionnaires online …

This study looks at how internet habits, cyberbullying, and emotional coping skills relate to mental health in young people aged 15 to 24. Researchers will survey 50 participants about their internet use, depression, anxiety, and self-harm thoughts. The goal is to better understa…

This study aims to find which patients with treatment-resistant depression are most likely to get relief from a single low dose of IV ketamine. Researchers will use interviews, questionnaires, brain wave tests, and computer tasks to look for clues. The goal is to make this treatm…

This study looks at how transcranial magnetic stimulation (TMS) affects a brain area called the subgenual cingulate, which is linked to depression. Researchers will give 54 adults with depression daily TMS sessions for 4-6 weeks, along with MRI scans, to see how this brain region…

This study looks at whether a single 2-hour group discussion for parents and caregivers can improve eating habits, mood, and parent-child relationships. About 112 Oregon parents of teens (ages 12-17) will either join the talk now or wait. Researchers will measure changes in both …

This study gives ketamine to 120 people with major depression and suicidal thoughts who are not on other psychiatric medications. Researchers use brain scans and a gentle nose swab to see how ketamine changes brain connections and neuron activity. The goal is to understand why ke…

This study looks at how stress influences long-term mood and thinking in 75 older adults with depression. Participants receive standard antidepressant treatment while researchers track their depression severity, memory, and brain activity using MRI scans. The goal is to understan…

This study looks at whether training pediatricians to assess how mothers and babies interact can help identify early signs of child behavior issues or postpartum depression. Over 3,500 mother-child pairs are involved, with babies seen at their one-month checkup. The goal is to se…

This study explores how a specific brain area (the medial prefrontal cortex) influences the ability to savor positive experiences in people with depression. Researchers will use non-invasive brain stimulation (TMS) and brain scans (EEG and fMRI) to see if changing activity in thi…

This study observes 35 people in residential treatment for substance use disorders to measure behavioral rigidity—the tendency to get stuck in inflexible thinking patterns. Participants complete weekly questionnaires and have their therapy sessions analyzed for language patterns.…

This study aimed to see if measuring sertraline (Zoloft) levels in the blood and checking a specific gene (CYP2C19) could help doctors give the right dose to people with major depression. The goal was to reduce side effects and improve treatment. However, the study was withdrawn …

This study is collecting data from 350 people with major depression to build an AI tool that helps doctors choose the best antidepressant for each patient. Researchers are analyzing blood, gut bacteria, brain activity, and genetics to find patterns that predict treatment success.…

This study aimed to see if electronic cigarettes could help people with depression smoke less or quit. It planned to follow smokers for 12 months, measuring how many cut down or stopped. However, the study was withdrawn before enrolling anyone, so no results were collected.

This study tests whether a Norwegian clinic (NSAC) helps people with common mental health issues or muscle pain return to work sooner. 2500 adults are split into three groups: one gets treatment quickly, one waits 10-14 weeks, and one gets a basic check-up. Researchers will track…

This pilot study aims to see if a larger trial on chiropractic care for adults with mild to moderate depression is possible. Researchers will enroll 20 adults and check if they can stick with the study procedures, like attending sessions and completing surveys. The study does not…

This study looks at whether having a licensed counselor available can improve the mental well-being of medical residents (doctors in training). The researchers will measure changes in well-being, depression, and anxiety. 21 internal medicine residents from the University of Nevad…

This study tests whether low intensity focused ultrasound can change negative thought patterns in people with depression. Researchers will target a key brain network involved in mind-wandering and self-judgment. 80 participants will receive both real and sham ultrasound sessions …

This study tests whether an early assessment of activity limitations by occupational therapists can help people with mental disorders return to work. 150 participants in specialized psychiatric care will either receive the assessment or usual care. The goal is to see if this lead…

This study aims to find better ways to ensure veterans with PTSD, depression, or alcohol/opioid problems receive proven treatments. Currently, only 3-28% of patients get these effective therapies. Researchers will compare a participatory business engineering method (Participatory…

This study is creating a large registry of 5,000 young people aged 8 to 20 who have depression or suicidal thoughts. Researchers will collect data from clinics across Texas to better understand these conditions and develop models to predict outcomes. The goal is to improve popula…

This study was designed to test the safety and feasibility of a focused ultrasound device called Exablate Neuro with a new Echo-Focusing feature for people with treatment-resistant brain disorders like essential tremor or depression. However, the trial was withdrawn before enroll…

This study looks at how things like social support, income, and health habits are linked to mental health and brain diseases such as depression, Alzheimer's, and Parkinson's. Researchers will collect surveys, blood samples, and optional brain scans from over 1,300 adults in Europ…

This study looks at two treatments for severe depression: electroconvulsive therapy (ECT) and antidepressant medication. Researchers want to see which one works better and is more cost-effective in the long run. The study involves 220 adults in the Netherlands who have not gotten…

This study was designed to test whether scheduled video calls with a nurse could help family members who make medical decisions for hospitalized older adults with Alzheimer's or similar cognitive issues. The goal was to improve communication and reduce anxiety and depression. How…

This study looks at how Transcranial Magnetic Stimulation (TMS) changes the brain in people with major depression. Researchers will use MRI scans to track these changes over 6 weeks. The goal is to better understand how TMS works, not to test a new treatment. 40 adults aged 18-65…

This study tests a video-based mobile app designed to reduce mental health stigma and medical mistrust among Black adults with moderate to severe depression or anxiety. Participants watch personal stories from others with similar experiences. The goal is to see if this approach i…

This study was designed to explore how cariprazine (Vraylar) might help people with bipolar depression by looking at its effect on a specific brain receptor (D3 dopamine). Participants would have taken cariprazine for six weeks and undergone PET scans to see how the drug works in…

This study aimed to develop and test a 12-week mental health program designed specifically for young South Asian women aged 16-24 with mood or anxiety disorders. The program was meant to address cultural and gender needs. However, the study was withdrawn before any participants w…

This study explores why Black, Indigenous, and People of Color (BIPOC) may have lower rates of starting and sticking with antidepressants after a one-time psychiatric consultation. Researchers will survey 60 adults diagnosed with depression to see if race affects whether they get…

This study follows 2,600 adults with coronary heart disease and depression who received a stent. Researchers track major heart problems like heart attacks or death over one year to find what predicts these events. The goal is to better understand the link between depression and h…

This study looks at a program called the Collaborative Behavioral Health Program (CBHP) for treating depression in primary care. The program brings together primary care doctors, behavioral health managers, and psychiatrists to work as a team. Researchers will track how well the …

This study tests whether giving doctors a summary of their patient's survey answers before a consultation helps people on sick leave return to work. About 1180 adults in Norway are taking part. The goal is to see if this simple nudge improves recovery and reduces time off work.

This study looks at whether an 8-week program of daily brain training exercises, combined with a gentle electrical current applied to the scalp (tDCS), can improve thinking, reduce falls, and help seniors with mental health conditions stay independent. About 270 older adults livi…

This study looks at how older adults with major depression handle emotions and make choices compared to healthy adults. Researchers will use brain scans and computer tasks to measure emotional recognition, reward processing, and impulsivity. The goal is to better understand the b…

This study tests whether a 12-week program that combines brain training, social activities, and exercise is practical and liked by seniors with mental health conditions living in community housing. About 18 participants will try the program in small groups, guided by a support wo…

This study tests whether a culturally tailored mobile health program can improve mental health and pregnancy outcomes in Black pregnant women. Half of the 150 participants will receive the program, which builds communication and self-advocacy skills and provides support. The goal…

This study is developing and testing a smartphone app called R-Assist for people recently released from jail who have both substance use and mental health disorders. The app tracks symptoms, connects users to resources like housing and recovery groups, and measures how easy it is…

This observational study will follow 384 patients in Brazil who are using cannabis-based products (like CBD or THC oils) prescribed by their own doctors for chronic pain, anxiety, or depression. Researchers will not provide the medication but will track patients' quality of life,…

This study looks at how mood disorders and insomnia interact by monitoring heart and brain activity. Researchers will measure signals like heart rate variability and brain waves in 200 people, including healthy volunteers and those with mood or sleep issues. The goal is to unders…

This study looks at how low field magnetic stimulation changes brain activity in older adults (age 60+) with bipolar depression. Forty participants receive both real and sham (fake) stimulation on separate days, with brain scans taken before and after each session. The goal is to…

This study looks at whether specific brain wave patterns (gamma oscillations) can help predict how well ketamine therapy works for people with treatment-resistant depression. Researchers will measure brain activity using EEG before and during ketamine treatment and track depressi…

This study looks at tobacco, cannabis, and other drug use among homeless and at-risk youth in downtown Ottawa. Researchers will follow 520 participants aged 16 and older who are homeless or insecurely housed and have a history of cannabis use and mental illness. The goal is to un…

This study explores whether a personalized therapy method called Process-based Therapy is practical in regular mental health clinics. About 40 adults with depression or anxiety will try this approach, and researchers will measure how satisfied patients and therapists are with it.…

This study looks at how a meditation program called TARA changes brain connections in teens aged 14 to 18 with mild or moderate depression. Researchers will use brain scans to see if meditation strengthens a key brain area and reduces depression symptoms. The goal is to understan…

This study observes 65 adults with major depression or bipolar depression who are receiving electroconvulsive therapy (ECT) as part of their routine care. Researchers track how two different anesthetics—ketamine plus propofol versus propofol alone—affect depression severity, suic…

This study uses health records from about 100,000 people in Israel to see if past viral infections (like Epstein-Barr, COVID-19, or herpes) increase the risk of developing mental illnesses such as depression, anxiety, bipolar disorder, or schizophrenia. It also looks at whether i…

This study explores whether highlighting certain words in questionnaire instructions (like 'bothered by') affects how people with depression or anxiety respond. Two hundred U.S. adults who have been treated for these conditions in the past year will take the same survey twice in …

This study aims to understand how the brain's pain-processing systems relate to a person's ability to attempt suicide. Researchers will use fMRI scans to measure brain activity in 90 adults with depression while they experience pressure pain. The goal is to identify neural patter…

About 11% of new mothers experience postpartum depression, which can affect their baby's growth and development. This study tests whether treating mothers with blue light therapy improves their infants' development and growth during the first year of life. Researchers will compar…

This study aimed to track brain activity in people with depression over time and see how a single dose of ketamine might change it. It was withdrawn before any participants were enrolled, so no results are available.

This study looks at how lithium, a common treatment for bipolar disorder, affects the brain's wiring. Researchers will use MRI scans to track changes in brain connections over 26 weeks in 120 adults with bipolar depression. The goal is to understand why lithium works, not to test…

This study was designed to test a new computer-based tool that uses pictures of food to measure how much pleasure and motivation people with major depression feel. The goal was to compare these responses between depressed patients and healthy volunteers to better understand depre…

This study is analyzing blood samples from 1,799 people with Alzheimer's, dementia, depression, bipolar disorder, schizophrenia, or Parkinson's disease. Researchers want to see if certain substances in the blood can help doctors diagnose and manage these conditions more accuratel…

This study looks at whether having naturally low testosterone levels increases the risk of dementia, depression, or anxiety. Researchers will analyze genetic data from large biobanks (like UK Biobank) to see if certain genes linked to low testosterone are also linked to these men…

This study looks at how to help VA medical centers offer virtual programs that prevent heart disease, diabetes, and depression in women Veterans. Researchers are testing two different support strategies at 20 VA sites to see which works better. The study does not involve patients…

This study was designed to see if low-intensity focused ultrasound could safely change brain activity related to emotion and thinking. It planned to test the device on healthy volunteers using brain scans. However, the study was withdrawn before enrolling any participants, so no …

This study tests an 8-week school program called INSPIRE, designed to help Indonesian teenagers aged 13-15 learn about mental health, build resilience, and reduce symptoms of depression and anxiety. Trained school counselors deliver the program using lesson plans and activities, …

This study was designed to test a holistic education program for stress management in people from colonized English-speaking countries. It aimed to help with conditions like stress, PTSD, anxiety, and fatigue using pastoral counseling and self-care activities. However, the study …

This study will use advanced heart scans (coronary CT angiography) on 4,000 people with rheumatoid arthritis aged 50-75. The goal is to better understand why people with this condition have higher risks of heart attacks, strokes, and lung problems. Researchers will track particip…

This study is collecting DNA, brain scans, and other biological samples from 2,000 people with major depression, bipolar disorder, or psychotic disorders, as well as healthy volunteers. The goal is to better understand the physical and genetic factors behind these conditions, whi…

This study was designed to understand why electroconvulsive therapy (ECT) sometimes causes temporary memory problems. Researchers planned to measure brain waves in people with severe depression or bipolar disorder receiving ECT. The study was withdrawn before any participants wer…

This study tests a method called SAIA-MH to help clinics in Mozambique better diagnose, treat, and follow up with people who have mental health conditions. Researchers will compare clinics using this approach to those that don't, involving about 155 patients. The goal is to see i…

This study looks at whether a hormone called oxytocin, measured in saliva during a psychedelic therapy session, can help predict how well people with major depression respond to treatment. Researchers will track changes in depression symptoms, flexibility in thinking, and anxiety…

This study follows over 6,000 people over many years to see if feelings like hostility and other psychological factors are linked to heart disease. Researchers are tracking who develops heart problems and looking for patterns. The goal is to better understand how our minds and em…

This study uses brain scans and magnetic stimulation to compare brain activity in 160 adults with autism, depression, both, or neither. Researchers want to understand how brain inflammation and the balance of excitation and inhibition relate to social and emotional symptoms. No t…

This study looks at whether brain scans can help predict which veterans with hard-to-treat depression will get better with a treatment called transcranial magnetic stimulation (TMS). Researchers will use MRI scans to measure brain activity before and during TMS therapy. The goal …

This study looks at whether brain wave patterns recorded during and after electroconvulsive therapy (ECT) can predict how much depression symptoms improve. About 31 adults with treatment-resistant depression will have their brain activity measured with a wearable EEG device. The …

This study tests whether using virtual reality (VR) during a C-section can lower the chances of postpartum depression and anxiety. Researchers will compare 98 pregnant women who use VR during surgery to those who don't, measuring mood and brain chemicals linked to depression. The…

This study will survey 25,000 people in China with mood disorders like bipolar disorder or major depression. Researchers want to understand what factors increase the risk of suicide or self-harm. They will follow 1,000 participants for one year to see if their predictions hold tr…

This study looks at two different methods to help VA clinics adopt a team-based depression care service for veterans living with HIV. The service has been shown to work well and save money, but no VA clinics currently use it. Researchers will compare the two approaches to see whi…

This study looks at whether taking antidepressants can reduce gum inflammation in people with chronic periodontitis (gum disease) and depression. Researchers will collect gum fluid and plaque samples from 92 patients during routine dental procedures. The goal is to see if depress…

This study aims to find brain activity patterns that can predict how people with major depression will respond to different treatments. Researchers will use a non-invasive brain imaging device (TD-fNIRS) to measure brain function in 540 adults before they start treatment. The goa…

This study looks at how people who have had major depression in the past make decisions when faced with choices that involve risk or reward. Researchers use brain scans (MRI) and computer tasks to understand which brain areas are involved. The goal is to find patterns that might …

This study looks at how transcranial magnetic stimulation (TMS) changes brain connections in people with major depression. Researchers will use MRI scans to measure brain activity before and after TMS treatment. The study involves 54 adults aged 18-80 who are already receiving TM…

This study looks at brain tissue and lab-grown nerve cells from people with schizophrenia, depression, bipolar disorder, frontotemporal dementia, and Alzheimer's. Researchers want to find out how problems with synapses—the connections between brain cells—differ in these condition…

This study was designed to track stress in real time by measuring things like heart rate, sweat, and temperature, along with how people feel. It planned to include both healthy volunteers and people with psychiatric disorders to find better ways to diagnose stress-related problem…

This study follows 192 teens aged 12 to 20 who are already receiving either Cognitive Behavioral Therapy (CBT) or Brief Strategic Therapy (BST) for anxiety, depression, or OCD. Researchers will track their progress using questionnaires and interviews over 9 months. The goal is to…

This study looks at whether mild whole-body hyperthermia (raising body temperature to about 101.3°F) can help treat major depression by affecting the immune system. Researchers will give some participants a drug that blocks IL-6 (tocilizumab) and others a placebo before the heati…

This study tests whether a team charter—a simple written agreement that clarifies roles and coordination—can help doctors and staff screen children for depression more consistently and connect them to mental health services faster. Forty healthcare providers at a children's hospi…

This study follows over 19,000 older adults who previously took aspirin in a clinical trial. Researchers are monitoring them for delayed effects on cancer, dementia, disability, and death. The goal is to see if aspirin has any long-term benefits or risks years after stopping the …

This study was designed to see if combining low-dose ketamine injections with interpersonal therapy could help improve mood in low-income women after a C-section. The researchers planned to enroll 0 participants and the study was withdrawn before it began. No results are availabl…

This study is testing whether an EEG (a simple brain wave recording) can predict which veterans with treatment-resistant depression will improve with transcranial magnetic stimulation (TMS). About 266 veterans will get EEG scans before, during, and after TMS treatment. The goal i…

This study tests whether brain wave (EEG) measurements can predict who will get better from a non-invasive magnetic stimulation treatment for depression called rTMS. Researchers will treat 30 adults with depression using rTMS and compare their EEG patterns before and after treatm…

This research studies a program that places social workers in 25 children's doctor offices across Indiana. The goal is to help doctors spot and treat mental health issues like depression and anxiety sooner. About 575 patients and staff will take part to see if this approach impro…

This study aims to understand how depression symptoms, like loss of interest, may make it harder for teens and young adults with lupus to keep up with their medical care. Researchers will also test a mobile health app designed to provide education and connect users to their care …

This study looks at how a nasal spray called esketamine can quickly reduce suicidal thoughts in people with severe depression. Researchers want to find out if symptoms like loss of pleasure (anhedonia) or emotional pain can predict who will benefit most. The study re-analyzes dat…

This study looks back at 376 patients who received psychedelic-assisted therapy with LSD or psilocybin for depression, anxiety, PTSD, or substance use disorders. Researchers want to see if the intensity of the psychedelic experience is linked to better outcomes. All data comes fr…

This study aimed to see if a fast-acting form of brain stimulation (called accelerated TMS) could change brain activity linked to suicidal thinking in adults hospitalized for major depression. The researchers planned to measure changes in suicidal thoughts using a standard questi…

This study planned to test a noninvasive device that stimulates the vagus nerve through the skin to see if it could help people recover consciousness more quickly after anesthesia. The researchers wanted to enroll adults undergoing lumbar spine surgery and measure how fast they w…

This study aimed to see if a drug called LY-2940094 could protect healthy adults from developing depression- or anxiety-like symptoms after stress. Researchers planned to give the drug to participants and then measure their brain responses to rewards and fear. However, the trial …

This study explores a personalized form of brain stimulation called resonant frequency rTMS for people with major depression. Researchers will test different stimulation frequencies to see which one best engages brain circuits. The goal is to develop a more targeted treatment app…

This study interviews 18 physiotherapists in private practice to understand how they screen for anxiety and depression in patients with chronic neck, shoulder, and low back pain. The goal is to identify what helps or hinders these mental health checks. The study does not test any…

This study examines blood samples from 46 people with treatment-resistant depression who took psilocybin in a previous trial. Researchers will measure markers of inflammation (cytokines and mRNA) to see if they relate to how well the treatment worked. The goal is to understand wh…

This study tests whether a brain stimulation technique, called theta-burst stimulation, can help predict if depression will come back in people who are currently in remission. Researchers will measure brain activity changes during stimulation using a special imaging cap. The goal…

This study looks at why depression often comes back in older adults and how it affects memory and thinking. Researchers will follow 210 people aged 60 and older, some currently depressed and some in remission, using brain scans and daily mood tracking. The goal is to find biologi…

This study gathers MRI, CT, and ultrasound images from 300 adults—some healthy, some with kidney or brain disease—to build a collection for future not-for-profit research. No new treatments are being tested; the goal is to make medical images available to scientists for advancing…

This study is testing whether data from smartphones and wearable devices can predict when a person with depression or bipolar disorder might have another episode. Over 12 months, 540 participants will wear a Fitbit, log daily moods, and complete five check-ins. Researchers will u…