New pill aims to lift depression in days, not weeks

NCT ID NCT06785012

Ongoing Symptom relief Sponsor: Janssen Research & Development, LLC Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 31, 2026 · Updated 3 times

Summary

This study tests an experimental drug called JNJ-89495120 in 107 adults with major depression. The goal is to see if it can reduce depression symptoms faster than a placebo, with checks as early as day 2 and day 5. Participants take the drug alone (no other antidepressants) and are monitored for safety and mood changes.

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Conditions

The condition(s) this trial relates to.

major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEPRESSIVE DISORDER, MAJOR

Contacts and locations

Locations

ATP Clinical Research

Orange, California, 92866, United States
Accelerated Clinical Research Group LLC

Snellville, Georgia, 30078, United States
Advanced Research Institute of Miami

Homestead, Florida, 33030, United States
Alpine Research Organization

Clinton, Utah, 84015, United States
Anderson Clinical Research

Redlands, California, 92374, United States
Artemis Institute for Clinical Research

San Diego, California, 92103, United States
Best Choice Medical and Research Service

Pembroke Pines, Florida, 33024, United States
CBH Health

Gaithersburg, Maryland, 20877, United States
CI Trials

Bellflower, California, 90706, United States
Chandler Clinical Trials

Chandler, Arizona, 85224, United States
Coastal Carolina Research Center

North Charleston, South Carolina, 29405, United States
Core Clinical Research

Everett, Washington, 98201, United States
DelRicht Research

New Orleans, Louisiana, 70115, United States
Gulfcoast Medical Research Center

Fort Myers, Florida, 33912, United States
Health Synergy Clinical Research

West Palm Beach, Florida, 33407, United States
IMA Clinical Research PC Phoenix

Phoenix, Arizona, 85012, United States
Indiana University IU Health

Indianapolis, Indiana, 46202, United States
Inland Psychiatric Medical Group Inc

Temecula, California, 92591, United States
Integrative Clinical Trials LLC

Brooklyn, New York, 11229, United States
Interventional Psychiatry of Tampa Bay

Tampa, Florida, 33629, United States
K2 Medical Research

Maitland, Florida, 32751, United States
Lumos Clinical Research Center LLC

San Jose, California, 95124, United States
Mountain View Clinical Research

Denver, Colorado, 80209, United States
National Institute Of Clinical Research

Garden Grove, California, 92844, United States
Noble Clinical Research

Tucson, Arizona, 85704, United States
OSU Department of Psychiatry and Behavioral Health

Columbus, Ohio, 43210, United States
Paradigm Research Professionals, LLC

Oklahoma City, Oklahoma, 73116, United States
Patient Priority Clinical Sites LLC

Cincinnati, Ohio, 45215, United States
Pharmax Research Clinic Inc

Miami, Florida, 33126, United States
Revival Research Institute LLC

McKinney, Texas, 75071, United States
Sunwise Clinical Research

Walnut Creek, California, 94596, United States
Synexus Clinical Research US Inc

Atlanta, Georgia, 30328, United States
Syrentis Clinical Research

Santa Ana, California, 92705, United States
The Medici Medical Research

Hollywood, Florida, 33021, United States
UAB Huntsville Regional Medical Campus

Huntsville, Alabama, 35801, United States
University of Arizona

Tucson, Arizona, 85724, United States
University of Chicago Medical Center

Chicago, Illinois, 60637, United States
University of Cincinnati

Cincinnati, Ohio, 45219, United States
University of Massachusetts Medical School

Worcester, Massachusetts, 01655, United States
University of Pennsylvania

Philadelphia, Pennsylvania, 19104, United States
WR-Newport Beach

Newport Beach, California, 92660, United States
Wake Research PRI Encino

Encino, California, 91316, United States
Wellness Research Center

Miami, Florida, 33135, United States
iResearch Atlanta LLC

Decatur, Georgia, 30030, United States

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