Tailored TMS shows promise for Treatment-Resistant depression

NCT ID NCT06003309

Completed Symptom relief Sponsor: University of California, San Diego Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether personalizing transcranial magnetic stimulation (TMS) based on an individual's brain structure and activity could improve outcomes for people with treatment-resistant depression. 75 adults received 20 sessions over 4 weeks, comparing fully personalized TMS, partially personalized TMS, and standard TMS. The main goal was to measure changes in brain connectivity, with depression symptoms also tracked.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Transcranial Magnetic Stimulation (TMS)
What this could lead to: If successful, this could lead to more effective, personalized TMS treatments for people with depression that hasn't responded to standard therapy.
What could go wrong: This is a small, early-stage study focused on brain activity changes, not yet proven to improve symptoms. The personalized approach may not work better than standard TMS.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MAJOR DEPRESSIVE DISORDER

Contacts and locations

Locations

Australian National University

Canberra, 2601, Australia
University of California, San Diego

La Jolla, California, 92093, United States

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