Fast brain stimulation shows promise for stubborn depression

NCT ID NCT06783361

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested an accelerated form of transcranial magnetic stimulation (TMS) in 50 adults with treatment-resistant depression. Participants received 50 sessions over two weeks, comparing a bilateral approach (stimulating both sides of the brain) with a unilateral one (stimulating only the left side). The goal was to see which method better reduces depression and anxiety symptoms. TMS is a non-invasive procedure that uses magnetic pulses to stimulate brain areas linked to mood.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Transcranial magnetic stimulation (TMS) – a non-invasive brain stimulation device
What this could lead to
If successful, this could point toward a faster, more effective TMS protocol for people with depression that hasn't responded to medication.
What could go wrong
This is a small, completed study (50 people) comparing two TMS methods. Results may not apply to everyone, and TMS can cause scalp discomfort or headache. It is not a cure.

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Conditions

The condition(s) this trial relates to.

Depressive Disorder, Treatment-Resistant major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Ataturk University

    Erzurum, 25240, Turkey (Türkiye)

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