Mouth disorder

This trial tests whether rinsing with coconut oil can reduce plaque and gum inflammation as effectively as a standard chlorhexidine mouthwash. Eighty adults with plaque-induced gingivitis will be split into two groups: one using coconut oil daily and the other using chlorhexidine…

This study is testing whether applying a silver diamine fluoride gel followed by a fluoride varnish can stop cavities in children's baby teeth. Researchers will follow 237 children for a year to see how many cavities become inactive and whether parents are satisfied with the trea…

This trial tests whether herbal mouthwashes containing tea tree oil, thyme hydrosol, or essential oils can reduce the plaque and gum inflammation seen in gingivitis. About 52 adults with gingivitis will use one of these mouthwashes or a placebo twice daily for three months, along…

This trial tests two gentler ways to treat cavities in children's baby molars: the Hall technique, which fits a stainless steel crown without removing decay, and atraumatic restorative treatment (ART), which uses hand tools and adhesive fillings. It compares these to the conventi…

This study compares two popular mouthwashes, Listerine and Chlorhexidine, to see which better controls gum inflammation and plaque in people undergoing orthodontic treatment with braces. Sixty participants aged 13-40 will use one of the rinses and be checked at 2 and 4 weeks. The…

This study tests whether doing a gum graft at the same time as placing a dental implant works as well as the traditional two-step approach. The goal is to increase the width of keratinized gum tissue around implants, which helps prevent inflammation and implant failure. Twenty-tw…

This trial asks whether a newer filling material called zirconomer holds up better than a standard glass ionomer cement when repairing cavities in children's baby molars. About 30 children aged 5 to 7 with a cavity in a back baby tooth will receive one of the two fillings. Resear…

This trial tests three types of tooth-colored fillings in children's baby molars to see which performs best. It compares a preheated bulk-fill composite with two indirect composite systems, looking at how well they hold up, how they look, and whether they cause any problems. The …

This trial tests whether propolis, a natural resin from bees, can control bleeding during a tooth-saving procedure called full pulpotomy for adults with painful, inflamed molars. Participants are randomly assigned to receive propolis or the standard sodium hypochlorite as a hemos…

This trial tests whether using artificial intelligence and computer guidance to lift the sinus floor and place dental implants immediately, along with a graft made from the patient's own tooth, improves outcomes compared to the traditional free-hand method. The study includes peo…

This trial investigates whether a topical clobetasol gel can change the levels of microRNAs in the gum fluid of people with oral lichen planus, a chronic inflammatory condition. Participants will apply either the active gel or a placebo to their lesions, and researchers will comp…

This study compares two types of tooth-colored fillings—alkasite and glass ionomer—for cavities in baby molars. Children aged 5 to 7 with decayed molars will receive one of the two materials, and the fillings will be checked over time for signs of new decay, color match, and how …

This trial investigates whether using a socket sealing abutment, with or without bone graft material, helps preserve bone and soft tissue after immediate molar implant placement. Adults aged 18-45 with non-restorable molars will receive the implant right after extraction, and the…

This trial tests two different mouthwashes—benzydamine hydrochloride and super saturated calcium phosphate—to see which better prevents and manages oral mucositis, a painful inflammation of the mouth lining, in head and neck cancer patients receiving radiation therapy. Participan…

This study tests a new toothpaste with stannous fluoride to see if it improves gum health and reduces plaque better than regular fluoride toothpaste. About 300 adults with mild to moderate gum inflammation will brush with the test toothpaste for 24 weeks. Researchers will measure…

This trial tests whether adding a procedure to shrink the inferior turbinates—small structures inside the nose—during adenoidectomy gives children aged 9 to 18 better relief from nasal blockage and sleep-disordered breathing than adenoidectomy alone. Participants have both adenoi…

This trial tests whether a three-tone plaque-disclosing gel, which stains old and new plaque in different colors, can help people with gingivitis clean their teeth more effectively than standard brushing instructions alone. Sixty-four adults with gingivitis will be randomly assig…

This study tested whether giving the immunotherapy drug durvalumab alongside radiation works better than the standard cetuximab plus radiation for people with advanced head and neck cancer who cannot take the usual chemotherapy drug cisplatin. A total of 196 adults took part. The…

This study tested whether giving lower doses of radiation after surgery for head and neck cancer could reduce long-term side effects like dry mouth and trouble swallowing, while still keeping the cancer from coming back. About 200 patients with certain stages of oral, throat, or …

This early-phase trial tested a new approach for people with advanced head and neck cancer that has come back or spread. It combined specially trained natural killer (NK) immune cells with drugs that help the immune system attack cancer. The study enrolled 11 participants to chec…

This trial tests whether applying a liquid growth factor solution (LPCGF) to the tooth root during standard gum graft surgery can improve gum thickness and coverage. Twenty adults with receding gums will receive either the standard treatment or the standard treatment plus LPCGF. …

This trial tests whether photodynamic therapy (PDT) using methylene blue can control early-stage pericoronitis, a painful gum infection around partially erupted wisdom teeth. Thirty-four healthy young adults with early pericoronitis will receive either standard irrigation or PDT,…

This trial tests whether a calcium silicate cement outperforms the standard calcium hydroxide material when used to treat deep cavities close to the tooth's nerve. Adults aged 18 to 45 with at least one deep cavity will receive one of the two materials after partial decay removal…

This study compares two types of dental implants in people who need a short-span fixed bridge (fewer than four implants). One implant has a lateralized design intended to preserve the crestal bone around it, while the other is a standard version. The goal is to see whether the la…

This trial tests whether adding an interdental brush, water flosser, or rubber toothpick to twice-daily toothbrushing reduces plaque and gum bleeding more than brushing alone. Twenty-nine dental students with gingivitis will use each method in different sections of their mouth fo…

This study tests whether a combination of injectable platelet-rich fibrin (I-PRF) and a collagen membrane can improve coverage of receding gums. The trial includes adults with Miller Class II gum recession, a condition where the gum margin has moved away from the tooth. Participa…

This trial tests whether short dental implants can work as well as standard implants placed after sinus surgery for people with limited bone height in the upper back jaw. Participants have partial tooth loss and a shallow sinus floor that would normally require a sinus lift proce…

This trial compares two types of dental implant surfaces—Nanotite and Osseotite—to see which one integrates more successfully when placed by graduate students learning implant surgery. The study includes adults who already need dental implants for missing teeth. The goal is to fi…

This study looks at whether a specific dental implant can hold a temporary bridge right after being placed, so patients don't have to wait months for a permanent restoration. Researchers will follow 75 adults with missing back teeth who need a short bridge. The main question is w…

This trial tests whether a dental implant with a special lateralized design (Osseotite Certain Prevail) preserves more bone around the implant than a standard version. About 100 adults who need a short fixed bridge to replace missing teeth will receive one of the two implant type…

This pilot study tests whether micro-needling, combined with a gum-lifting procedure, can thicken receding gums as well as a standard gum graft substitute (Alloderm). Twenty-four adults with at least 3 mm of gum recession on a front tooth will receive one of the two treatments. T…

This study tests whether toothpaste containing arginine, an amino acid, can prevent cavities in children aged 10 to 14. Participants brush twice daily with one of three strengths of arginine toothpaste or a standard fluoride toothpaste for one year. Researchers measure new caviti…

This study compares a new single-shade tooth-colored filling material, Omnichroma, to a standard multi-shade filling in children aged 3 to 5 years who have cavities in both upper front teeth. The goal is to see if the one-shade material can match the color of the surrounding toot…

This trial compares different bioactive restorative materials and placement techniques to see how they affect the health of the tooth's pulp (nerve) after treating deep cavities. Researchers will measure inflammatory markers in the fluid around the tooth and track post-treatment …

This trial tests whether a liquid called silver diamine fluoride (SDF) can stop early cavities in molars as effectively as the standard treatment, a plastic coating called fissure sealant. Adults aged 20 to 45 with early, non-cavitated cavities will be randomly assigned to receiv…

This trial tests whether 3D-printed crowns work better than standard stainless-steel crowns for restoring damaged first permanent molars in children. The study will compare how well each crown holds up, its effect on gum health, and how satisfied children and parents are with the…

This study tests whether using hypochlorous acid—a mild disinfectant—during deep dental cleaning helps treat early-stage periodontitis (gum disease) better than cleaning with water alone. Researchers will measure gum healing, pocket depth, and inflammation markers in 44 adults wi…

This study compares two surgical techniques for treating gum recession: gingival unit grafting and conventional free gingival grafting. Researchers measure how well each graft matches the color of surrounding gum tissue and how much healthy gum tissue it adds over 18 months. The …

This trial tests whether using a low-power laser during a pulpotomy (removing infected pulp from a tooth) can improve healing and root formation in children aged 6 to 14 with painful, irreversible pulpitis in immature permanent molars. Participants receive either laser treatment …

This study tests whether a newer, easier-to-use material called NeoPUTTY works as well as the standard MTA for saving permanent back teeth with severe nerve inflammation in children aged 9 to 14. Both materials are used to cover the remaining healthy nerve after removing the dise…

This study tests whether watching a video about brushing and flossing is as effective as a hands-on demonstration with a 3D model for people with gingivitis (early gum disease). Eighty adults with gingivitis will receive either a video link or a live demo, and their gum health wi…

This study tests two types of pit and fissure sealants (Fisseal and Prevent Seal) applied after treating teeth with one of two remineralizing agents (Biflourid or MI Paste). The goal is to see which combination best keeps the sealant in place and prevents cavities from forming or…

This study compares two types of dental implant attachments used in full-arch fixed dentures (All-on-4) for people with no teeth in the lower jaw. The OT-Bridge system is tested against standard multiunit abutments to see which leads to higher patient satisfaction and fewer prost…

This trial compares two types of rotary files (Kedo-Nano Plus and Kedo-S Square) with traditional hand files for root canals in children's baby molars. About 60 healthy kids aged 5-8 with infected molars will receive a pulpectomy using one of the three tools. Researchers will che…

This study compares a new 1% nanochitosan solution to standard nystatin oral suspension for treating Newton's type II denture stomatitis, a fungal infection causing redness and inflammation under dentures. The trial enrolls 30 complete denture wearers diagnosed by an oral special…

This trial tests three different ways of placing resin composite fillings in deep cavities to see which one causes the least irritation to the tooth's nerve (pulp). Adults with deep decay in their molars will receive one of the filling techniques, and researchers will measure inf…

This study tests two types of fluoride varnish—one that hardens with a special light and a standard one—to see if they can reverse white spot lesions (early cavities) that often appear after braces are removed. About 38 teenagers who are finishing orthodontic treatment will recei…

This study tests whether a new Sonicare power toothbrush head removes more dental plaque and reduces gum inflammation (gingivitis) than a standard manual toothbrush. About 100 adults with gingivitis will brush twice daily with either the power or manual brush for six weeks. Resea…

This trial tests whether placing a hyaluronic acid gel into the empty socket after lower wisdom tooth removal can prevent dry socket—a painful condition where the blood clot fails to form or is lost. The study includes 64 healthy adults who need a lower wisdom tooth extracted. Re…

This study tested a new device that uses electrical pulses (IRE) to shrink enlarged tonsils in children, aiming to improve breathing without traditional surgery. Thirty-one children aged 3-18 with tonsil hypertrophy and airway obstruction took part. Researchers measured pain reco…

This trial tests whether specially framed text messages can improve oral health and quality of life in refugees living in Alexandria, Egypt. Participants receive either gain-framed messages (highlighting benefits of good oral care), loss-framed messages (highlighting risks of poo…

This study tested whether a vitamin D mouthwash can help repair weak spots on children's permanent teeth (a condition called molar incisor hypomineralization) and improve gum health. Thirty-two children over age 6 used either a vitamin D or placebo mouthwash. Researchers measured…

This study tests whether a daily dose of Taiwanese Green Propolis, a natural bee-derived supplement, can improve blood fat levels, reduce fatigue, and enhance quality of life in people who have completed treatment for oral cavity cancer. Participants take either propolis capsules…

This study tests whether leaving a tooth's root canal unfilled and using a blood clot to trigger natural healing works as well as the standard root canal filling. The trial involves 48 men with infected but still living upper premolars. One group gets the standard gutta-percha fi…

This study tested whether adding photodynamic therapy (a light-activated treatment) to standard sodium hypochlorite irrigation better kills bacteria in root canals. 64 adults needing root canal treatment were randomly assigned to receive either sodium hypochlorite alone or with p…

This trial tests whether adding a sticky bone graft to a standard gum flap procedure helps cover exposed tooth roots better than the flap alone. It includes 30 adults with mild-to-moderate gum recession. The study measures how much the gum covers the root and how thick the gum ti…

This study compares a new probiotic gel to a standard steroid gel for treating minor recurrent canker sores—painful mouth ulcers that make eating and talking difficult. Adults with these sores will apply either the probiotic or steroid gel four times daily for up to two weeks. Re…

This study tested a special drilling technique called osseodensification, which compresses bone instead of removing it, to prepare the jaw for dental implants. Twenty-three adults with missing teeth received about 40 implants using this method. The goal was to see if the techniqu…

This study tested three different materials used to treat severe, irreversible tooth inflammation. 72 adults with painful molars received a procedure where the damaged pulp was removed and covered with one of the materials. The goal was to see if newer materials (TheraCal LC and …

This study tested different application times (3 seconds to 2 minutes) of 38% silver diamine fluoride solution to see which works best for stopping cavities in preschool children. Over 600 healthy kids aged 3-5 with at least one cavity participated. Researchers checked if the cav…

This study looked at 40 adults aged 35–55 with a history of periodontitis (gum disease) who needed a dental implant. Each received one of two implant surface types: sandblasted acid-etched or plasma-sprayed. Researchers measured bone loss around the implant and gum health over on…

This study tested whether a stannous fluoride toothpaste can reduce gum inflammation, bleeding, and plaque better than a standard fluoride toothpaste. Over 12 weeks, 133 adults brushed with one of the two toothpastes and had their gums checked at several visits. The goal was to s…

This study tested whether a hands-on teaching method called Touch-to-Teach helps people with dental crowns clean between their teeth better than standard advice. 36 adults with at least one crown took part and were split into two groups: one got personalized brush training, the o…

This completed study tested a surgical technique called the combined bilaminar tunnel method for treating gum recession in patients with challenging tooth anatomy. Twelve participants received the procedure and were followed for six months. The goal was to see how much of the exp…

This study compared three approaches for treating dead, infected adult teeth: a regenerative procedure that induces bleeding inside the tooth, standard cleaning and sealing, and a combination. Fifty-four adults with an infected upper premolar were treated and followed for healing…

This study tested two types of fillings for deep cavities in back teeth: a new bioactive material and a standard non-bioactive one. Fifty adults aged 18-40 with deep cavities were treated using a technique that removes only the decayed part. The researchers checked tooth sensitiv…

This study tested a new, less invasive way to treat infected baby molars in children aged 4 to 10. Instead of fully cleaning out the tooth canals (standard pulpectomy), the new method uses an antibiotic paste to kill infection without drilling. The study involved 110 children and…

This phase 2 trial tested a biologic drug called RC18 in 42 people with primary Sjögren's syndrome, an autoimmune disease that causes dry eyes and mouth. Participants received weekly injections of either RC18 (at 160 mg or 240 mg) or a placebo for 24 weeks. The goal was to see if…

This study tested whether using a stannous fluoride toothpaste, a cetylpyridinium chloride mouthwash, and a battery-powered toothbrush together can reduce dental plaque and gingivitis (gum inflammation). 134 adults with at least 20 teeth and signs of gum disease used the regimen …

This study tested a new type of dental implant called T3 to see if it helps preserve the jawbone better than a standard implant. Forty adults who needed dental implants took part. Researchers checked how well the implant stayed in place and how much bone was kept over time.

This study tested two types of dental fillings for cavities and tooth wear at the gum line in 20 professional ballet dancers. One filling was a ceramic-like material (PICN) and the other was a self-hardening composite. Over 24 months, the ceramic fillings had zero failures, while…

This Phase 2 trial tested a drug called CFZ533 (iscalimab) in 273 adults with Sjögren's syndrome, an autoimmune disease causing dryness, pain, and fatigue. Participants received either the drug or a placebo for 24 weeks. The study measured changes in disease activity and symptoms…

This study tested a surgical technique for treating multiple receding gums. Twenty-one adults with gum recession on both sides of the mouth received a modified tunnel procedure with a connective tissue graft. The researchers compared two ways of placing the graft to see which gav…

This study tested two ways to treat receding gums: a new material made from the patient's own blood (T-PRF) and a standard connective tissue graft. Twenty healthy adults with gum recession on both sides of the mouth received both treatments, one on each side. The researchers meas…

This study looked at whether adding a surface sealant to a bulk fill dental filling helps it last longer and resist staining. 53 patients received three different fillings each, with or without a sealant. The fillings were checked every 6 months for 5 years to see if they failed,…

This study tested a chlorhexidine varnish applied to teeth in people with braces. Each person's mouth was split: one side got the active varnish, the other a placebo. Over 3 months, researchers measured gum overgrowth, plaque buildup, and early tooth decay (white spots). The goal…

This study tested whether a self-assembly peptide, with or without laser treatment, can help remineralize (repair) early cavities. Thirty adults with active early decay were treated and monitored for one year. The goal was to see if these approaches could reverse the early damage…

This study tested whether adding microneedling before standard gum surgery (coronally advanced flap) improves root coverage for people with thin gums and receding gums. Thirty-six adults with isolated gum recession on upper front teeth were randomly assigned to receive either mic…

This study tested whether a custom digital surgical guide helps dentists perform crown lengthening more accurately than the usual method. Twenty-four adults with gummy smiles due to a condition called altered passive eruption took part. The digital guide uses 3D scans and imaging…

This study tested whether a mouthrinse with benzydamine hydrochloride could reduce plaque buildup when people stopped brushing for three days. Fifty healthy women with no gum disease used either the active mouthrinse or a placebo. The results showed no significant difference in p…

This study tested whether toothpaste containing hops extract can reduce gum inflammation (gingivitis) better than standard fluoride toothpaste. 120 adults brushed twice daily for 3 months with one of four toothpastes. Researchers measured bleeding and gum health to see if the hop…

This study tested two materials, ProRoot MTA and Biofactor MTA, for direct pulp capping—a procedure to save a tooth's nerve after exposure. Eighty permanent teeth were treated, and patients reported pain levels for 48 hours. Success was checked at 6 and 12 months by looking for s…

This study tested a new type of ceramic crown that can be made and placed in a single dental visit, avoiding the need for temporary crowns. Fifty adults with decayed, fractured, or poorly filled molars or premolars received these crowns and were followed for up to five years. The…

This study tested different types of bulk-fill tooth fillings in 40 adults who had at least 4 cavities in their back teeth. The fillings were placed and then checked after 2 years to see how well they held up. The goal was to find out which filling material works best for treatin…

This study tested two types of dental crowns for children's back teeth: white zirconia crowns and traditional silver-colored metal crowns. Researchers treated 35 healthy kids aged 6-9 with cavities on multiple tooth surfaces. They checked how well each crown held up and asked par…

This study tested a new way to rebuild the lower jaw after removing benign tumors. Surgeons used virtual 3D planning to create custom-made plates and combined them with a piece of the patient's own rib bone. Thirty people took part, and the team checked how well the wounds healed…

This study tested whether injectable platelet-rich fibrin (i-PRF), titanium platelet-rich fibrin (t-PRF), or hyaluronic acid gel can improve wound healing after gum surgery for overgrown gums. Sixty healthy adults were randomly assigned to one of four groups. Researchers measured…

This study looked at whether a special gel could help treat gum disease. Twelve adults with moderate gum disease received standard deep cleaning plus the gel. They also used the gel and a special toothpaste at home. After 8 weeks, their gum pockets and bleeding improved. The stud…

This study tested a porcine collagen matrix (Mucoderm) against the standard connective tissue graft for covering exposed tooth roots due to gum recession. Eighteen adults with gum recession on both sides of the mouth received one treatment on each side. The goal was to see if the…

This phase 2 trial tested darolutamide, a drug that blocks male hormones, in 57 people with a rare type of salivary gland cancer that has male hormone receptors. Some patients received darolutamide alone, while others also got goserelin to lower hormone levels. The goal was to se…

This study tested two daily-use mouth rinses containing chlorhexidine (CHX) plus either hydrogen peroxide or cetylpyridinium chloride against a placebo rinse. Over 3 months, 81 adults used the rinse twice daily alongside normal brushing. Researchers measured plaque buildup, gum i…

This study tested two types of ceramic dental restorations for teeth that have had root canal treatment: overlays and endocrowns. Twenty-five patients received one of the two restorations, and researchers checked how well they fit, any color changes at the edges, and how satisfie…

This trial tested a new dental cement called ALBO-MPCA in 20 adults with tooth decay. The cement is designed to stimulate the tooth to grow new dentin, the hard layer under the enamel. The goal was to see if it is safe and effective for repairing cavities and protecting the tooth…

This study tested a product called DoReMin to see if it can help repair early tooth decay (white spot lesions). 43 adults with at least two early cavities on different teeth took part. One tooth was treated with DoReMin, while a similar tooth was left untreated for comparison. Re…

This study tested three ways to stop early cavities in children's baby molars: fluoride varnish alone, a resin coating alone, or both together. Twenty-six kids aged 4 to 9 with very early, non-cavitated cavities were treated and checked over 12 months. The goal was to see which a…

This study compared two treatments for severely decayed baby molars in children aged 4 to 9. One group received a pulpotomy, where only the infected part of the tooth's nerve is removed and replaced with a special cement (Biodentine). The other group had a full pulpectomy, removi…

This study tested a new material called Mucoderm, made from donated animal tissue, to treat receding gums. It compared it to the standard treatment, which uses a small piece of tissue from the patient's own palate. The goal was to see if Mucoderm could cover exposed tooth roots j…

This study tested a blend of six Chinese herbs, called Anti-tumor B, in 30 people with squamous cell cancer of the mouth. The goal was to see if the herbs could slow cancer cell growth before standard treatment. Results focused on changes in a cell growth marker called Ki-67.

This study tested whether a probiotic called Lactobacillus rhamnosus Lcr35® can reduce the number of painful canker sores in people who get them often. Twenty adults with frequent outbreaks took either the probiotic or a placebo daily for 3 months, then were monitored for another…

This study tested whether a new Colgate toothpaste with dual zinc can better control plaque and gingivitis (gum inflammation) compared to a standard cavity protection toothpaste. 86 adults with mild to moderate plaque and gum issues used one of the two toothpastes for three month…

This study compared a stannous fluoride toothpaste paired with a newly designed toothbrush to a standard toothpaste and brush for reducing plaque and gingivitis (gum inflammation). 95 adults with mild to moderate gum issues used their assigned products for 3 months. Researchers m…

This study tested whether using a stannous fluoride toothpaste along with a cetylpyridinium chloride mouthwash and a manual toothbrush reduces dental plaque and gingivitis better than using regular fluoride toothpaste with a standard toothbrush. Eighty-two adults with mild gum di…

This study tested two types of tooth-colored fillings for cavities in back teeth: a self-hardening composite that sets without a special light, and a light-activated bioactive composite. Fifty adults received one of the two fillings, and their performance was tracked for two year…

This completed Phase 2 study enrolled 84 adults with mild to moderate plaque and gingivitis. Participants were randomly assigned to use one of two manual toothbrush and toothpaste regimens at home for 6 weeks. Dentists measured plaque and gum inflammation at 1, 3, and 6 weeks to …

This study tested whether using a stannous fluoride toothpaste along with a cetylpyridinium chloride mouthwash can improve gum health and reduce plaque buildup better than using regular fluoride toothpaste alone. About 199 adults with mild gum disease (gingivitis) took part. Rese…

This study tested two types of dental fillings for cavities that form near the gum line on front teeth. Fifty adults received either an alkasite-based resin composite or a resin modified glass ionomer filling. Dentists checked the fillings right away, at 6 months, and at 1 year t…

This study tested a new, less invasive surgery for receding gums. 24 adults with gum recession received a procedure using a donated tissue graft placed through a small tunnel under the gum. The goal was to cover exposed tooth roots and improve gum health. Results showed the treat…

This study tested whether baricitinib, a drug already used for rheumatoid arthritis, can help people with active Sjogren's syndrome. 87 participants were randomly assigned to receive either hydroxychloroquine alone or baricitinib plus hydroxychloroquine for 24 weeks. The goal was…

This study compared two types of dental crowns for children's baby molars: the standard stainless steel crown and a newer, tooth-colored BIOFLX crown. Researchers treated 36 children who had at least two decayed baby molars needing crowns. They checked the crowns after 1, 3, 6, a…

This phase II trial tested whether adding sorafenib to cetuximab works better than cetuximab alone for patients with advanced head and neck cancer that has come back or spread. Fifty-five adults with various types of head and neck cancer took part. The study measured how long pat…

This study tested a new way to treat children aged 6 to 18 who have a dead nerve in an immature tooth. The new method uses a material called MTA to help the tooth form a hard barrier, compared to the standard treatment with calcium hydroxide. The goal was to see which method work…

This study tested three cavity treatments in 60 children aged 4-8 years. Each child received all three treatments on different baby molars: the Hall Technique (a cap placed without drilling), silver diamine fluoride (a liquid that stops decay), and a standard tooth-colored fillin…

This study tested two different places to take gum tissue for grafting—the back of the mouth (tuberosity) or the roof of the mouth (palate)—to fix receding gums on a single tooth. Thirty healthy adults with gum recession received one of the two grafts along with a gum-lifting pro…

This study looked at whether a toothpaste made from black seed (Nigella sativa) can lower signs of gum inflammation in 100 Indonesian soldiers with gingivitis. Researchers measured certain proteins in saliva that are linked to gum disease. The goal was to see if this toothpaste c…

This study tested whether adding a hyaluronic acid gel to standard gum surgery (coronally advanced flap) helps treat type 1 gum recession. Twenty adults with gum recession on both sides of the mouth took part. The gel aims to improve gum coverage and reduce discomfort. Results we…

This study tested two simpler procedures called Lesion Sterilization and Tissue Repair (LSTR) against the standard root canal treatment (pulpectomy) for infected baby molars in 66 children. One LSTR method cleaned the root canals, while the other only removed the top pulp and pla…

This study tested whether a mouthwash made from Triphala, an Ayurvedic herbal formula, works as well as the standard chlorhexidine mouthwash for reducing plaque and gum inflammation. 220 adults with mild to moderate gingivitis used one of the two mouthwashes twice daily for 30 da…

This study tested whether a stronger solution of sodium hypochlorite (5% vs 3%) works better as a wash and bleeding stopper during a partial pulpotomy—a procedure to save a tooth with deep decay and nerve inflammation. The trial involved 128 adults with painful, infected molars. …

This study looked at the long-term safety of efgartigimod in 24 adults with primary Sjögren's syndrome who had already completed a prior trial. Efgartigimod works by lowering certain antibodies that may drive the disease. The main goal was to track side effects over 48 weeks, wit…

This study tested whether a toothpaste containing fluoride and baking soda could help repair early tooth decay. Thirty-one healthy adults wore a custom mouthpiece with pieces of damaged enamel for nine days. They brushed with different toothpastes and then researchers measured ho…

This study tested whether TheraBreath toothpaste helps prevent cavities by strengthening tooth enamel. 31 adults wore a dental appliance with enamel samples and used different toothpastes to compare how much fluoride was absorbed and how well enamel recovered. The goal was to see…

This study tested a minimally invasive injection molding technique to restore front teeth affected by enamel hypoplasia in 14 children. The method uses a special resin injected into a clear stent to rebuild the tooth surface. The goal was to see how well the restoration holds up …

This study tested a new type of dental filling that hardens on its own, without needing a special light. Researchers compared it to two other common filling materials in 60 cavities across 20 people. They checked the fillings at several points over one year to see how well they h…

This study compared two surgical techniques to treat receding gums: the pinhole technique and the tunnel technique. 21 adults with gum recession received both procedures on different teeth. The goal was to see which method better covered exposed roots and increased gum thickness …

This study compared two surgical methods for removing adenoids in 128 children: the traditional cold curettage and a newer coblation technique using endoscopes. The goal was to see which method leaves less leftover tissue and causes fewer complications. The coblation method uses …

This study tested whether a mouthwash made from guava leaf extract can reduce plaque and gum inflammation as well as a standard chlorhexidine mouthwash. 160 adults with chronic gingivitis rinsed twice daily for up to 90 days. Researchers measured plaque buildup and gum health to …

This study tested two ways of placing a collagen membrane during immediate dental implant placement in 20 healthy adults with badly decayed front teeth. The goal was to see which method better preserves bone and gum thickness around the implant. Results were measured using 3D sca…

This study tested whether a special toothpaste could help repair early tooth decay. Thirty adults wore a dental device with enamel samples for one week while using different toothpastes. Researchers measured how much the enamel hardened and how much fluoride it absorbed. The goal…

This completed phase II study tested a combination of two drugs—tadalafil (Cialis) and pembrolizumab (Keytruda)—in 7 adults with advanced head and neck cancer that had spread or come back. The goal was to see if the combination was safe and could help control the disease. Because…

This study looked at using a special filling material called OrthoMTA for root canals in second baby molars that have no permanent tooth growing underneath. Thirteen children received the treatment and were checked for up to 12 months to see if the tooth stayed healthy and infect…

This study tested whether a 45°-cut miswak (a natural chewing stick) removes dental plaque as well as a toothbrush in children aged 6 to 14. Researchers measured plaque levels and asked kids which tool they preferred. The goal is to find effective, culturally acceptable ways to i…

This study involved 24 adults with receding gums to see if adding an enamel protein to a standard gum graft procedure improves results. The standard method uses a tissue graft placed under the gum with a small tunnel. Half the participants also got the enamel protein. Researchers…

This study tested whether using a special toothpaste and mouthwash together with a manual toothbrush works better than regular fluoride toothpaste alone for reducing plaque and improving gum health. 90 adults with mild to moderate gum problems brushed twice daily for 12 weeks. Re…

This study compared two dental treatments for deep cavities in children's baby molars: indirect pulp treatment and direct pulp capping. Both used a special material (MTA) and a crown. Forty-five healthy children aged 7-9 took part, and the success was checked after 6 and 12 month…

This study tested a drug called ianalumab in 21 adults with Sjögren's syndrome, an autoimmune disease that causes dry eyes and mouth. The goal was to understand how the drug works in the salivary glands and check its safety. Participants received injections of ianalumab and had b…

This study tested a combination of two drugs, pembrolizumab and cetuximab, in 78 people with advanced head and neck cancer that had returned or spread. The goal was to see if the combination could shrink tumors or slow the disease. Participants were grouped based on whether they …

This study tested whether adding hyaluronic acid to a standard chlorhexidine mouthwash helps treat gingivitis (gum inflammation). Sixteen adults with gingivitis used two different mouthwashes after a professional teeth cleaning. Researchers measured bleeding and plaque levels to …

This study tested whether ozonated olive oil gel can help dental implants fuse with the jawbone as well as a standard injectable bone graft. Sixteen adults needing a tooth replacement received an immediate implant after extraction, with either the oil gel or bone graft applied ar…

This study looked at two different bulk-fill materials used to repair cavities in children's baby molars using a gentle, drill-free method called atraumatic restorative treatment (ART). Researchers treated 127 children aged 4-9 and checked the fillings at 3, 6, and 12 months to s…

This completed trial compared two surgical techniques—frenotomy and frenectomy—for treating high frenum attachment in 46 healthy, non-smoking adults. The goal was to see which procedure leads to less relapse and less pain. Participants were randomly assigned to one of the two sur…

This study tested whether tocilizumab, a drug that blocks inflammation, can help people with primary Sjögren's syndrome—an autoimmune disease causing dry eyes, dry mouth, pain, and fatigue. Researchers gave 110 participants either tocilizumab or a placebo to see if it could reduc…

This study tested whether a special light device used at home can improve oral health in teenagers with braces. Forty teens used the device daily for two months, while others received standard brushing instructions. The goal was to see if the device reduces plaque and gum bleedin…

This study tested two types of dental overlays in 20 children aged 8-13 with Molar-Incisor Hypomineralisation (MIH), a condition that weakens enamel and causes tooth sensitivity. Each child received one overlay made from a hybrid composite and another from a hybrid ceramic, place…

This study looked at whether a root canal for an infected tooth with an abscess can be done in one visit instead of two. Fifty-nine adults received either a single-visit treatment or a two-visit treatment with a calcium hydroxide medication placed in between. After 12 months, bot…

This study tested a less invasive treatment called vital pulp therapy against standard root canals for teeth with severe pulp inflammation. In the new approach, dentists removed only the inflamed pulp and placed a natural blood-derived material (PRF) to help the tooth heal. Forty…

This study tested whether an experimental toothpaste with stannous fluoride, zinc chloride, and alumina can improve gum health better than a regular fluoride toothpaste. 175 adults with mild to moderate gingivitis used the toothpaste for 4 weeks. Researchers measured gum bleeding…

This study tested whether a medical glue (butyl-cyanoacrylate) works as well as traditional stitches for holding gum grafts in place. Twenty-four adults with thin gums received either glue or stitches after graft surgery. Researchers tracked healing, graft size, patient comfort, …

This study tested whether injecting a substance made from a patient's own blood—called injectable platelet-rich fibrin (i-PRF)—could reduce root shortening that sometimes happens when wearing braces. Thirty-six adults with crowded front teeth received either i-PRF or a saltwater …

This study tested three treatments for multiple receding gums in 60 healthy adults. It compared a collagen matrix, platelet-rich fibrin, and a connective tissue graft to see which covers exposed tooth roots best. The goal was to improve gum health and appearance.

This study looked at whether giving radiation therapy after surgery can prevent early-stage oral cancer from coming back. It included 392 patients with tumors at least 5mm thick. Half received radiation, half were just watched. The main goal was to see if radiation reduced local …

This study tested two new methods to treat dental ankylosis, a condition where a tooth fuses to the jawbone, stopping normal growth. Five people aged 6 to 30 received either electric toothbrush vibration or mini-implant-assisted force to move the affected tooth. Researchers measu…

This completed trial tested two surgical procedures to reduce a gummy smile (excessive gum display when smiling). Sixteen women aged 18 to 30 received either a modified lip repositioning surgery or a Z-plasty frenectomy. Researchers measured how much the gum show decreased, pain …

This early study tested a drug called KH001 to see if it could help teeth naturally repair deep cavities. Twelve adults with a decayed wisdom tooth received the treatment. Researchers then checked the teeth for new dentin growth and monitored for side effects.

This study tested whether analyzing the genes of a person's salivary gland tumor could help doctors pick a more effective drug. 114 people with advanced or returning cancer joined. First, their tumor was genetically profiled. Then, if a targetable gene change was found, they got …

This study tested two types of denture material for people with no teeth who got implant-supported overdentures. Sixteen patients received either a standard acrylic denture or a flexible resin one. Researchers measured gum pocket depth, plaque buildup, and Candida yeast growth to…

This study tested two dental materials, TheraCal PT and Biodentine, for pulpotomy (removing infected pulp) in baby teeth of 60 children aged 6-9. It also examined whether adding low-level laser therapy improves success. The goal was to see which approach keeps the tooth healthy a…

This study tested two drugs, apremilast and methotrexate, added to standard steroid treatment for oral lichen planus, a chronic inflammatory mouth condition causing pain and sores. 64 adults with moderate to severe disease who didn't respond to topical steroids took either apremi…

This study tests whether a special light-based scanner, called DIAGNOcam, can better detect early cavities between teeth when used with a dye. Researchers will compare this method to standard X-rays and a visual-tactile exam. The goal is to see if the dye improves the ability to …

This study looks at whether substances in the blood from a tooth's pulp can help dentists tell the difference between reversible pulpitis (a mild inflammation that can heal) and irreversible pulpitis (severe damage needing a root canal). Researchers will collect a small sample of…

This trial tests whether a new hybrid tracer, ICG-99mTc-nanoscan, can replace the standard tracer for sentinel node biopsy in people with penile cancer, melanoma, or oral cancer. The hybrid tracer combines a fluorescent dye with a radioactive marker, potentially allowing surgeons…

This study develops and tests an artificial intelligence model that analyzes standard dental photographs to detect gum recession, classify its severity, and suggest treatment options. Researchers use images from adults with visible gum recession to train the AI and compare its ac…

This study evaluates how accurately the Root ZX3 electronic apex locator measures the working length of root canals in single-rooted teeth that need to be extracted. Researchers compare the device's measurements with microscopic measurements taken after extraction, which serve as…

This study tests whether a non-invasive imaging tool called swept-source optical coherence tomography (SS-OCT) can detect early signs of tooth erosion caused by acidic drinks. Twenty-two healthy adults swished orange juice repeatedly over three days, and their teeth were scanned …

This study tested whether a 3D cone-beam CT scan (a type of X-ray) can diagnose non-cancerous salivary gland diseases as well as MRI. Fifty adults with symptoms like swelling or pain in their salivary glands underwent both imaging methods. The goal was to see if the 3D-CBCT could…

This study tested whether a special light (autofluorescence) can help doctors spot early signs of mouth cancer in people who smoke and drink heavily. 180 adults hospitalized for alcohol withdrawal took part. The goal was to see if the light technique is more reliable than a stand…

This study tested an artificial intelligence (AI) algorithm designed to analyze images of minor salivary gland biopsies to help diagnose Sjogren's syndrome. Researchers used 1,000 biopsy samples from patients with suspected Sjogren's to see if the AI could accurately count immune…

This study tested four methods for finding early tooth decay in children aged 6 to 14. Researchers compared standard visual inspection with three special tools that use light or lasers. The goal was to see which method works best for spotting cavities that haven't yet formed a ho…

This study tested a new type of PET-CT scanner that can scan a tumor right after it is removed from the body. Patients with prostate or head and neck cancer received a small amount of radioactive tracer before surgery, which sticks to cancer cells. After removal, the specimen was…

This study tested how well cold, heat, and electric pulp tests detect tooth nerve health in 175 adults needing root canals. Researchers compared test results to direct observation of nerve bleeding during treatment. The goal was to find which test is most accurate for diagnosing …

This study tested whether an artificial intelligence (AI) program could reliably find cavities between teeth (proximal caries) on digital dental X-rays. Researchers compared the AI's performance to diagnoses made by expert dentists. The study involved 2000 participants and used b…

This study tested a new pain scoring tool to help dentists tell apart reversible and irreversible pulpitis, a common diagnostic challenge. Researchers enrolled 143 patients with tooth pain and compared the tool's results with two standard classification systems. The goal was to s…

This completed study looked at whether lupus patients already taking hydroxychloroquine long-term had a lower risk of catching COVID-19 or developing severe symptoms. Researchers compared 552 patients who either took the drug or did not, using blood tests and questionnaires. The …

This study tests whether a new toothpaste can prevent enamel erosion better than a standard cavity-protection toothpaste. Eighty healthy adults will brush twice daily for 18 days with either the test or control toothpaste. Researchers will measure enamel loss on a small block wor…

This trial investigates whether a low-level diode laser can prevent or reduce severe mouth sores (mucositis) caused by radiation and chemotherapy in people with advanced head and neck cancer. Participants receive either real laser therapy or a non-functional placebo laser during …

This study tested four different dental filling materials in 120 adults at high risk for cavities. The goal was to see if newer 'bioactive' materials could prevent secondary cavities (cavities that form around the edge of a filling) better than a standard composite resin. Partici…

This study tested three methods of keeping teeth dry while applying protective sealants to prevent cavities in children's permanent molars. Thirty children at high risk for cavities took part, and each method was compared for how long it took, how well the sealant stayed on after…

This study tested three early treatments—fluoride varnish, conventional sealant, and self-etch sealant—on 132 children's partially erupted permanent molars with early cavity signs. The goal was to see which best prevents cavities from forming or getting worse. Researchers tracked…

This study tested whether fluoride or probiotic toothpaste can prevent cavities in 508 children aged 4-5. Kids brushed twice daily for 12 months with either fluoride, probiotic, or plain toothpaste. Researchers also surveyed eating and brushing habits to find risk factors for cav…

This study tested whether sending WhatsApp messages that offer a discount or suggest scheduling a dental check-up on the same day as a medical appointment increases preventive dental care. Over 300,000 adults in Chile who had a medical visit coming up and hadn't seen a dentist in…

This study tested a procedure called Periodontally Accelerated Osteogenic Orthodontics (PAOO) in 20 adults getting braces. The goal was to see if it could prevent bone loss and gum recession on the front of the lower teeth. The procedure combines a small cut in the gum with a bon…

This study tested whether giving kids a connected toothbrush and a behavioral health app after cavity surgery helps them brush better and lowers dental costs. 93 children aged 4-7 who had surgery for cavities used the smart toothbrush and received motivational texts. Researchers …

This study tested whether probiotic lozenges can prevent white spots (early cavities) that often appear around braces. 75 healthy people with braces took part. Some used probiotic lozenges, some used a control lozenge, and some had no extra treatment. The researchers measured new…

This study tested whether teaching parents about oral hygiene, diet, and fluoride can prevent early childhood cavities. One hundred parents of children aged 0-3 took part. The intervention group received structured education sessions with booklets and videos. The goal was to impr…

This study looked at three types of tooth sealants made from glass ionomer to prevent cavities in children's back teeth. Two hundred healthy kids aged 6 to 12 got sealants on their lower first molars and were checked over 24 months. The goal was to see which sealant stayed on bes…

This study tested a new way to apply dental sealants (a protective coating) to prevent cavities in young adults aged 17-22. Researchers compared sealants placed with or without a pre-treatment using a bioactive glass air abrasion (a gentle spray of special glass particles). The g…

This study compares four treatments—clonazepam, capsaicin, photobiomodulation (light therapy), and alpha-lipoic acid—against a placebo for burning mouth syndrome. Researchers will enroll 150 adults with daily oral burning for over 3 months. The goal is to see which approach best …

This study tests whether a toothpaste designed for sensitive teeth can also improve oral hygiene and gum health in people with dentine hypersensitivity. Participants will use the toothpaste over time, and researchers will measure changes in tooth sensitivity, plaque buildup, and …

This trial tests whether listening to preferred music or squeezing a stress ball during cataract surgery can reduce patients' pain and anxiety. About 240 adults having their first cataract surgery will be assigned to one of these two simple, drug-free techniques or to standard ca…

This trial tests whether a mouthwash containing lithium can prevent or reduce oral mucositis (painful mouth sores) and dysgeusia (taste changes) in people receiving radiation for head and neck tumors. Participants will rinse with either a lithium mouthwash or a placebo during the…

This trial tests whether low-level laser therapy or a hyaluronic acid gel can improve healing after free gingival graft surgery, a procedure to treat receding gums. Adults with insufficient gum tissue in the lower front teeth will receive surgery alone, surgery plus laser, or sur…

This study looked at how well paracetamol alone or combined with different NSAIDs (ibuprofen, mefenamic acid, or diclofenac) controls pain after root canal treatment. 185 adults with severe tooth pain took part. The goal was to see if combining drugs works better than paracetamol…

This study tests whether a water flosser can improve oral health in adults with plaque-induced gingivitis. Sixty-four healthy adults will use the device twice daily after brushing. Researchers will measure changes in plaque and gum inflammation over time.

This trial investigates whether placing a retraction cord—a thin thread that pushes the gum aside—during a tooth restoration affects gum health. Adults with non-carious cervical lesions (tooth damage near the gumline not caused by decay) will receive composite restorations either…

This trial tests whether two experimental mouthwashes can relieve dentinal hypersensitivity—sharp pain from hot, cold, or air on teeth. About 118 adults with sensitive teeth will use one of the mouthwashes or a placebo, either once or twice daily, for up to 8 weeks. Researchers w…

This trial compares a toothpaste with stannous fluoride against a popular potassium-based desensitizing toothpaste and a regular fluoride toothpaste. About 116 adults with sensitive teeth will brush twice daily for a week. The goal is to see if the stannous fluoride formula reduc…

This trial asks whether photobiomodulation — a type of low-level laser therapy — can lessen pain and swelling after endodontic (root-end) surgery. Thirty-four adults needing surgery on an upper tooth will be randomly assigned to receive either the laser treatment or a sham proced…

This trial tests whether sucking lemon candy and using honey mouthwash can reduce salivary gland damage caused by radioiodine therapy for thyroid cancer. About 120 adults who have had their thyroid removed and are about to receive radioiodine will be randomly assigned to the cand…

This study looks back at medical records of adults with head and neck cancer who developed painful mouth sores from radiation or chemotherapy. Researchers will compare how well laser therapy and ozone therapy eased those sores and reduced pain. The goal is to see if one approach …

This trial compares two irrigation solutions used during regenerative endodontic treatment for immature permanent teeth with infection. Forty children aged 9 to 16 will receive either octenidine or EDTA as a rinse, and their pain levels will be tracked for a week. The goal is to …

This trial tests whether warming up dental filling materials before placement can reduce inflammation inside the tooth and lessen pain after treatment. Thirty adults with deep cavities will receive fillings at different temperatures — one group gets a special flowable composite p…

This trial tests whether an all-in-one dental isolation system called Isolite is more comfortable for children than the traditional rubber dam during cavity treatment. Sixty-six kids aged 8 to 12 will try both methods in random order, and researchers will measure pain, comfort, a…

This trial tests two non-surgical injectable treatments for a gummy smile, where too much gum shows when smiling. Twenty adults with a gummy smile of 3 mm or more received either botulinum toxin (Botox) or a hyaluronic acid filler. The study measures how much the gum exposure is …

This trial compares two ways of giving the anti-inflammatory drug piroxicam to control pain after root canal treatment: a standard oral pill versus an injection into the ligament around the tooth. Adults with a toothache caused by irreversible pulpitis will receive one of the two…

This study tests whether using cooled liquid to clean the inside of a tooth during root canal treatment can reduce pain afterward. It includes adults with certain tooth conditions who need a root canal. The approach involves comparing cooled versus room-temperature irrigation to …

This trial compares two minimally invasive treatments—Antivet and Opalustre—for improving the appearance of mild enamel fluorosis, a condition that causes tooth discoloration. Adults aged 20 to 35 with mild fluorosis on their front teeth are randomly assigned to receive one of th…

This trial tests whether a corticosteroid injection given before root canal treatment can reduce pain and inflammation afterward. One hundred adults with symptomatic pulpitis (tooth nerve inflammation) are randomly assigned to receive either standard root canal treatment alone or…

Dental fluorosis can leave chalky white spots on front teeth, affecting appearance even when the enamel is intact. This trial compares two gentle treatments—resin infiltration and enamel microabrasion followed by a calcium-phosphate paste—for masking those spots. Researchers meas…

This study tested whether injecting vitamins C or E into the gums could help teeth move faster during braces treatment. 51 patients received either vitamin C, vitamin E, or a placebo injection every two weeks to a month for six months. Researchers measured tooth movement, pain, a…

This study tests whether a paste made from chitosan nanoparticles can heal minor mouth ulcers and reduce pain better than a standard steroid ointment. Thirty people with recurrent aphthous stomatitis (canker sores) will apply either the chitosan paste or the steroid paste to thei…

This study looked at two treatments for oral lichen planus, a chronic mouth condition that can cause pain and change how food tastes. Researchers compared a light-based treatment (photodynamic therapy) with steroid cream in 65 adults. They measured taste ability, pain, and lesion…

This study compares two ways of teaching oral hygiene to adults with braces who have gum inflammation (gingivitis). One group gets personalized training called iTOP, while the other gets standard video and model instruction. Researchers will measure plaque and gum health after th…

This study tests whether taking ibuprofen before a root canal can improve the effectiveness of local anesthesia in people with severe tooth inflammation (irreversible pulpitis). Participants will receive either ibuprofen or a placebo before the procedure, and pain levels will be …

This study compares three treatments for recurrent aphthous stomatitis (canker sores): St. John's wort oil, a topical corticosteroid, and hyaluronic acid gel. Researchers measure how well each reduces pain, shrinks ulcer size, and speeds healing in adults with a history of these …

This study tested whether adding thalidomide to glutamine can delay the onset of severe mouth sores caused by radiation therapy. 138 oral cancer patients were randomly assigned to receive either the combination or glutamine alone during their radiation treatment. The main goal wa…

This study looked at four different ways to activate the cleaning solution used during root canals: laser, sonic, ultrasonic, and simple needle irrigation. The goal was to see which method causes the least pain after the procedure and how much debris gets pushed out of the tooth.…

This study compares two final rinses inside the tooth after root canal treatment for people with severe tooth pain from irreversible pulpitis. One rinse is a cold saline solution (cryotherapy), the other is a steroid solution (dexamethasone). The goal is to see which better reduc…

This study tested whether using special lasers during root canal treatment can lower pain afterward compared to standard methods. Forty-five adults with infected front teeth were split into three groups: one got standard cleaning, another got a combination of two lasers, and the …

This study tested two ways to whiten teeth: a chemical bleaching gel and a light-activated bleaching gel. Thirty adults with yellowish or brownish stains on their front teeth were randomly assigned to one of the two methods. Researchers measured how white teeth got, how much toot…

This study tested whether dissolvable mineral-loaded starch strips can quickly relieve dentin hypersensitivity, a common condition causing sharp pain from hot, cold, or touch. 82 adults with sensitive teeth used either the strips or a Novamin toothpaste. The goal was to see if th…

This study looked at pain after root canal treatment using two types of sealers: bioceramic and resin. 72 adults with no pain before treatment had a single-root tooth filled. They rated their pain at 6, 24, 48, and 72 hours, and 7 days after. The goal was to see if the sealer typ…

This study tested whether taking tramadol or naproxen sodium one hour before a dental procedure helps local anesthesia work better and reduces pain afterward. 139 adults with severe tooth inflammation (irreversible pulpitis) in a lower molar were randomly given one of the two dru…

This study tested whether a mobile application could help nurses and caregivers better manage pressure injuries (bedsores) in people receiving home care. Thirty participants were followed for 28 days, with caregivers using the app to track wound healing and receive reminders. The…

This study tested a special lollipop containing the painkiller diclofenac to help children aged 4 to 12 manage pain after having their tonsils removed. Fifty children received a weight-adjusted dose every 8 hours for the first day after surgery. The goal was to see if the lollipo…

This study tested four approaches for treating dentine hypersensitivity (tooth sensitivity): Nd:YAG laser, diode laser, a herbal propolis-based gel, and a sham (fake) treatment. 140 adults with at least two sensitive teeth were followed for 12 months to see which method reduced p…

This study tested whether a technique called apical patency—gently passing a small file just beyond the tooth root during root canal treatment—reduces pain afterward. 150 adults with inflamed but painless teeth (asymptomatic irreversible pulpitis) were randomly assigned to receiv…

This trial investigates whether using an electronic apex locator to determine the exact stopping point during root canal treatment can reduce pain afterward. Participants with a single-rooted tooth needing a root canal are randomly assigned to one of three groups: two groups use …

This study looked back at medical records of 58 adult cancer patients who developed painful mouth sores from chemotherapy or radiation. They had been treated with a combination of ozone applied in the dentist's chair and ozone-based gels, toothpaste, and mouthwash at home. The go…

This study tested whether using an ultrasonic device to clean root canals causes less pain afterward than a standard needle. 108 adults with tooth pain had root canals and were randomly assigned to one method. Pain was measured using a scale. The goal is to find which cleaning me…

This study tested whether pain-relieving skin patches work as well as oral tablets for pain after root canal treatment. 80 adults with tooth pain received either a ketoprofen or fentanyl patch, or an oral medication. They rated their pain over 48 hours. The goal was to see if pat…

This study tested whether a smartphone app designed for patients having gallbladder removal surgery could reduce anxiety, complications, and improve comfort and satisfaction. 64 adults scheduled for laparoscopic cholecystectomy used the app during their hospital stay and recovery…

This study tested two treatments for tooth sensitivity: a special varnish and an air-polishing system. Thirty adults with sensitive teeth were treated, and researchers measured pain relief and any tooth color changes. The goal was to find which method works better for easing disc…

This study tested whether a special tooth gel can help adults with sensitive teeth. Thirty-one participants used the gel three times a day for two weeks. Researchers measured pain from cold air and touch before and after treatment to see if sensitivity improved.

This study tested whether a desensitizing toothpaste, used alone or with a mouthwash, can reduce tooth sensitivity in adults. 71 participants used the products daily for 14 days. Researchers measured changes in sensitivity to see if the toothpaste worked better than regular tooth…

This study tested whether a propolis mouth rinse could delay or prevent severe oral mucositis (painful mouth sores) in 140 head and neck cancer patients undergoing radiation. Participants used either a 15% propolis solution or a placebo four times daily alongside standard oral ca…

This study looked at whether using a special laser (diode laser) after a common dental procedure called direct pulp capping can help reduce pain and tooth sensitivity. Fifty-six people with tooth decay that reached the nerve were treated. Half got standard care, and half got stan…

This study tested whether massage and progressive muscle relaxation exercises can reduce the frequency and severity of muscle cramps in people undergoing hemodialysis. 79 patients participated, and the goal was to see if these non-drug approaches offer relief. The findings could …

This study tested a dental paste called Alveogyl in 120 people who developed a dry socket after a tooth extraction. The paste is placed into the socket by a dentist to relieve pain and help the gum heal. Researchers measured pain levels and healing over 7 days. The trial is alrea…

This study tested whether waiting 2 days or 7 days between in-office teeth whitening sessions affects tooth sensitivity. 47 adults with dark teeth received two bleaching sessions using a 35% hydrogen peroxide gel. Their pain levels were recorded for 48 hours after each session, a…

This study looked at whether a nose spray medicine called midazolam can help calm preschool children (ages 2-6) before they have surgery to remove their tonsils and adenoids. The goal was to make the children less anxious and more comfortable before anesthesia. The study included…

This study tested whether applying antibiotics directly into the tooth socket after wisdom tooth removal works as well as taking antibiotic pills. 90 adults having their lower wisdom teeth taken out were split into two groups: one got antibiotic gel at the surgery site, the other…

This study compared an oral steroid (prednisolone) to a partial root canal for relieving severe tooth pain from pulpitis. Only 5 adults with a painful lower molar took part. The goal was to see if the pill could reduce pain enough to delay the full root canal by 72 hours, potenti…

This study tested three biocompatible materials—TheraCal PT, Biodentin, and MTA—for reducing pain after a pulpotomy (removing the inner pulp) in 51 adults with severe toothache. Participants rated their pain before and up to 7 days after treatment. The goal is to find which mater…

This phase 3 trial tested whether ulinastatin, a drug that blocks certain enzymes, can reduce severe mouth sores caused by chemoradiotherapy in 179 patients with advanced nasopharyngeal cancer. Patients received either standard care or ulinastatin alongside their cancer treatment…

This pilot study tested whether a wheat-free and milk-free diet could reduce symptoms in people with Sjogren's syndrome, an autoimmune disease. Thirty participants were randomly assigned to either the special diet or a control diet. After two months, those on the wheat-free diet …

This study tested if zinc oxide ointment can help heal painful canker sores. One hundred people with canker sores used either the zinc ointment or a placebo three times a day for six days. Researchers measured pain and how the sores affected daily life to see if the ointment made…

This study tested a mineral mouth rinse (THERAVEX®) in 116 adults with primary burning mouth syndrome, a condition causing ongoing mouth pain. Participants rinsed with the mineral solution or a placebo for 8 weeks. The main goal was to see if the rinse reduced burning pain intens…

This study compared two common painkillers—diclofenac sodium and ibuprofen—for managing pain after a root canal. Sixty adults with irreversible pulpitis received one of the two drugs right after treatment, and their pain was tracked for 48 hours. The goal was to see which drug pr…

This study compared two ways to fill a root canal after treating a painful tooth infection (irreversible pulpitis). 56 people aged 18-60 took part. One group got a continuous wave condensation filling, the other a single-cone filling. Researchers measured how long each method too…

This study tested a new dental filling material against a standard one to see which looks better. 36 adults with cavities in their front teeth each got both fillings. Researchers measured patient satisfaction with the appearance using a scale. The goal was to see if the new mater…

This study tested a new device that uses high-voltage electric pulses to shrink enlarged tonsils without cutting. Twenty-four adults with grade 2 or higher tonsil hypertrophy received the treatment. The goal was to reduce tonsil size and pain, with results measured at 3 months.

This study tested whether giving children montelukast before and after tonsillectomy reduces their pain and need for strong painkillers. 116 kids aged 3-8 took part, receiving either montelukast or a placebo. Researchers measured pain scores and how often families contacted docto…

This study tested whether taking a specific probiotic (Limosilactobacillus reuteri) can improve gum health in adults with braces who also have gingivitis (gum inflammation). One hundred participants either received the probiotic or no supplement. Researchers measured gum bleeding…

This study tested two ways to treat early white spot lesions on teeth in 30 teenagers aged 12 to 18. Each participant received both a resin infiltration and a microabrasion treatment on different teeth to see which worked better. The goal was to improve the appearance and stop th…

This study tested whether listening to personally chosen music can reduce pain and anxiety during dental drilling. Thirty adults picked a relaxing song and had their heart rate, blood pressure, and pain levels measured with and without music. The goal is to see if music can be a …

This study tested a home-use light device and special mouth rinse to help people with oral lichen planus, a painful mouth condition. Thirteen participants used the device daily for a year alongside standard care. The goal was to see if it could reduce pain and inflammation better…

This study tested whether a new 2-in-1 foam toothpaste and mouthwash (Scigates) can reduce tooth sensitivity and whiten teeth better than a standard toothpaste. Fifty-seven adults with mild staining and sensitive teeth used either the Scigates product or a control toothpaste thre…

This study tested whether a toothpaste with stannous fluoride can reduce tooth sensitivity in 177 Chinese adults aged 18 to 70. Participants brushed twice daily for 8 weeks, and researchers measured pain response to air and touch. The goal was to see if the special toothpaste wor…

This study looked at whether applying ozone gas to surgical wounds in the mouth can help gums heal faster after gum surgery. Twenty-four people with enlarged gums due to chronic inflammation took part. Each person had two similar areas treated: one with standard surgery alone, an…

This study tested whether injecting dexamethasone, diclofenac sodium, or chymotrypsin into the gum before numbing medicine can make dental treatment less painful. 105 men with severe toothache took part. The goal was to see if these drugs help the numbing work better so patients …

This study tested whether applying cryotherapy (ice or cold saline) during dental procedures for deep cavities reduces pain and improves quality of life. 144 adults received either a pulpotomy or root canal treatment, with or without cryotherapy. The goal was to see if the cold t…

This study tested two different attachment systems (Equator and Novaloc) for lower dentures held in place by dental implants. The goal was to see which one helps dentures stay in place better and improves quality of life for people with no teeth. 26 adults aged 60-70 took part. T…

This study tested whether special pastes containing CPP-ACP and fluoride could reduce tooth sensitivity after in-office bleaching. 64 adults received either a paste with CPP-ACP and sodium fluoride, CPP-ACP and stannous fluoride, or a placebo before and after whitening. Pain was …

This study looked at 146 adults with painful tooth inflammation who needed root canal treatment. It compared two different tools (WaveOne and ProTaper) to see which one leads to less pain after the procedure. Patients rated their pain at several times over a week. The goal is to …

This study tested a resin coating on the front teeth of 40 children aged 7-14 who had weak enamel (hypomineralization or hypoplasia) and tooth sensitivity. The treatment aimed to reduce pain from cold air and improve how kids and parents felt about the look and function of their …

This study tested whether preheating a special tooth-colored filling material before placing it in cavities helps it last longer and cause less tooth sensitivity. Seventy adults with cavities on both sides of their mouth received one preheated and one non-preheated filling. Over …

This study tested whether a special ultrasonic handpiece that sprays hydroxyapatite (a natural enamel mineral) can reduce tooth sensitivity during dental cleanings for people with gum disease. Forty adults with moderate to severe periodontitis had half their mouth cleaned with th…

This study looked at whether regular aerobic exercise, like walking, can reduce fatigue in women with primary Sjögren's syndrome. Forty-five women participated in a 16-week program. Researchers measured changes in fatigue, mood, and physical fitness.

This study tested a custom 3D-printed PEEK shell placed under the gum in the upper jaw to reduce excessive gum display (gummy smile) in 10 patients. The shell was inserted through small incisions using a tunnel technique. The goal was to see if it could decrease the amount of gum…

This study tested a new device called Mucopad HA in 50 adults who had painful mouth sores (oral mucositis) after radiation therapy. The goal was to see if the pad is safe and helps the sores heal. Researchers measured healing time, pain levels, and dry mouth.

This study tested three different rinses used during root canal treatment to see which one causes the least pain afterward. Ninety adults with tooth pain took part, and each received one of the rinses: sodium hypochlorite, hydrogen peroxide, or normal saline. Pain levels were mea…

This study looked at 120 full-term newborns to see if placing them in different positions (on their back, side, or stomach) during a heel stick blood test could lower their pain and improve comfort. Researchers measured pain using standard scales and checked heart rate and oxygen…

This study tested two ways to teach people with gingivitis (early gum disease) how to clean their teeth better. One group watched a video, the other practiced on a dental model. After one month, both groups showed improved gum health and awareness, with no major difference betwee…

This completed Phase 3 trial tested whether a toothpaste with stannous fluoride reduces tooth sensitivity better than a potassium-based toothpaste or regular fluoride toothpaste. 123 adults with sensitive teeth used one of the three toothpastes for 7 days. The study measured sens…

This study tested whether a benzydamine hydrochloride (Difflam) oral spray can reduce the severity of mouth sores caused by high-dose radiation in head and neck cancer patients. Thirty-five adults receiving radiation without chemotherapy were randomly assigned to standard mouth c…

This study tested whether a toothpaste with 5% potassium nitrate can reduce tooth sensitivity better than a regular fluoride toothpaste. 80 adults with sensitive teeth used one of the two toothpastes for eight weeks. The researchers measured sensitivity using a gentle touch and a…

This study tested whether a special toothpaste with 8% arginine (CSPR) can reduce tooth sensitivity better than a regular Colgate toothpaste. 95 adults with sensitive teeth used the toothpaste for 8 weeks. Researchers measured sensitivity using a gentle touch test and a cold air …

This study tested a bioadhesive film made from Acmella oleracea (jambu), a plant with natural pain-relieving properties, to reduce tooth sensitivity during teeth whitening. 72 healthy adults received the film, a standard desensitizing gel, or a placebo before bleaching with hydro…

This study tested whether eye drops made from a patient's own blood (autologous serum) can relieve severe dry eye better than standard artificial tears. 46 adults with severe dry eye tried both diluted (20%) and full-strength (100%) serum drops, as well as artificial tears. The m…

This study looked at how well BioFlx crowns work for fixing cavities in children's back teeth. Twenty-eight kids aged 6 to 9 got the crowns and were checked for up to 24 months. The goal was to see how the crowns held up and how happy the children and parents were with them.

This study tested four different anesthesia drugs in 100 children aged 3-10 having tonsil surgery. The goal was to see which drug best prevents confusion and restlessness after waking up. Researchers measured pain, agitation, and recovery quality in the recovery room.

This study tested whether adding a propolis mouth rinse to standard oral care could prevent or reduce mouth sores in 60 COPD patients in the intensive care unit. Half the patients received propolis care for 15 days, while the other half got standard care only. Researchers checked…

This study compared how well manual and electric toothbrushes remove dental plaque in 50 healthy adults aged 21-25. Participants brushed with one type, and researchers measured plaque and gum health before and after. The goal was to see which toothbrush works better for everyday …

This study tested three types of dental crowns—nanohybrid composite, zirconia, and stainless steel—on the back baby teeth of 46 children aged 4 to 9. The goal was to see which crown lasts longest, looks best, and keeps gums healthy over one year. Results will help dentists choose…

This study tested a device called EDDY that uses sound waves to clean root canals better. Forty adults with infected teeth but no pain were treated. The sonic cleaning killed more bacteria than standard methods, but it did not reduce pain after the procedure compared to usual car…

This study tested a new gel-like desensitizer for people with sensitive teeth. 40 adults received either the new polycation-based desensitizer or a standard one. Researchers measured pain relief from touch and cold air. The goal was to see if the new gel safely reduces tooth sens…

This study tested whether a nightly warm foot bath can reduce fatigue in children aged 7-12 with lymphoma who are undergoing chemotherapy. Sixty children took a 20-minute foot bath at 38-40°C for 7 days. The goal was to see if this simple, non-drug approach could improve their en…

This study tested two treatments for tooth sensitivity: a special toothpaste with bioactive glass and a low-level laser. 100 adults with sensitive teeth were randomly assigned to one of these treatments or a placebo. The goal was to see which approach provides better and longer-l…

This study tested whether Gluma, bioactive glass, or a mix of both could reduce tooth sensitivity better than standard fluoride varnish. Forty adults with sensitive teeth were treated and followed for six months. The goal was to see which approach provided the most lasting relief…

This study looked at 60 adults who needed a single tooth replaced right after extraction. Researchers compared two types of implant surfaces and whether adding low-level laser therapy helped. The goal was to see which approach gave the best implant stability and least bone loss o…

This study tested a procedure called full pulpotomy (removing only the infected pulp inside the tooth crown) in 58 adults with severe toothache. It compared success in teeth with and without an infection at the root tip (apical periodontitis), using an AI tool to help detect the …

This study looked at 120 people who needed root canal treatment on their molars. Researchers tested different filling materials (bioceramic vs. resin-based) and techniques (cold vs. warm filling) to see which caused the least pain afterward. The goal is to help dentists choose op…

This study tested whether mouth rinses containing the amino acids arginine or glutamine could reduce the severity of painful mouth sores caused by radiation therapy in head and neck cancer patients. 69 participants swished and swallowed these supplements three times daily during …

This study tested two ways to protect gums during in-office teeth whitening: relative isolation (using a tray) and absolute isolation (covering gums completely). Thirty healthy adults with no cavities or gum disease took part. Researchers checked for gum irritation, tooth sensiti…

This study looked at 30 adults with braces and gum inflammation (gingivitis). Each person received two different cleanings—one side of the mouth got a newer method called Guided Biofilm Therapy (using air and powder), and the other side got the standard ultrasonic cleaning and po…

This study tested whether a desensitizing gel called UltraEZ can reduce tooth sensitivity during in-office bleaching. Thirty healthy adults with dark teeth received either UltraEZ or a placebo before bleaching. Researchers measured pain levels and color change to see if the gel h…

This study tested whether using a diode laser along with a potassium nitrate gel (a desensitizing toothpaste ingredient) works better than the gel alone for treating sensitive teeth. Twenty-three adults with tooth sensitivity received either the real laser plus gel or a sham lase…

This study tested two ways to remove bone during a minimally invasive sinus surgery called the prelacrimal approach. One method uses a modern ultrasonic device (piezosurgery), the other uses a traditional hammer and chisel. The trial included 40 adults with various non-cancerous …

This study tested two medications placed inside the tooth after an emergency root canal to see which one reduces pain better. 43 adults with severe tooth pain (pulpitis) received either calcium hydroxide or Tobradex (an antibiotic-steroid combo). Pain levels were measured before …

This study tested whether a toothpaste with NovaMin (Sensodyne Repair and Protect) can reduce tooth sensitivity during and after teeth bleaching. 90 adults used either the test toothpaste, a standard fluoride toothpaste, or another sensitivity toothpaste. Participants rated their…

This study looked at whether certain natural proteins in saliva are linked to severe tooth decay in young children. Researchers compared 50 Turkish children aged 3-6 with and without severe cavities. They measured levels of antimicrobial peptides in saliva to see if differences e…

This study looks at how smoking affects proteins linked to blood vessel formation in gum disease. Researchers will measure levels of KLF2, FBXW7, and other markers in fluid from around the teeth and in saliva from adults who are smokers or non-smokers, with healthy gums, gingivit…

This trial compares two different sequences of nickel-titanium (NiTi) archwires used in braces to see which one aligns teeth faster, causes less discomfort, and leads to less root shortening. It involves 60 people aged 12-35 who need full orthodontic treatment for crowding. Parti…

This study looked at how gum tissue heals when taken from two different areas of the palate (roof of the mouth) to treat receding gums. Forty healthy adults aged 20-40 had a gum graft taken either from the front or back of the palate. Using 3D scans, researchers measured volume c…

This study investigates whether proteins from the Hippo signaling pathway—known to control cell growth and bone health—are present at different levels in the gum fluid of people with healthy gums, gingivitis, or periodontitis. Researchers will collect fluid samples from 75 partic…

This study follows nearly 90,000 farmers and their spouses to track long-term health effects of pesticides, crops, and animals. Participants report new medical conditions, which researchers then confirm through medical records and genetic samples. The goal is to better understand…

This trial asks whether two common cleaning methods—mechanical polishing with a paste or applying a 35% hydrogen peroxide gel—change the readings of a laser device (DIAGNOdent) used to spot early tooth decay on the chewing surfaces of back teeth. In each participant, one side of …

This study looked at three substances in saliva—Adseverin, 1-alpha defensin, and sRANKL—to see if they differ between people with healthy gums, gingivitis, or periodontitis. Researchers collected saliva from 60 non-smoking, systemically healthy adults and measured these biomarker…

This study looks at how gum disease, from mild gingivitis to more severe periodontitis, changes the activity of certain genes and proteins involved in inflammation and cellular cleanup. Researchers will collect small gum tissue samples from people with healthy gums, gingivitis, o…

This study investigates whether stress inside gum cells plays a role in periodontal disease, which causes inflammation and damage to the tissues supporting the teeth. Researchers measured markers of cell stress and inflammation in fluid and tissue samples from 72 non-smoking adul…

This study looks at why gum disease (gingivitis) develops at different rates in different people. Healthy adults aged 18 to 35 will stop brushing and flossing for 3 weeks to allow mild gum inflammation to develop, then resume normal hygiene to recover. Researchers will take clini…

This study investigates whether specific proteins involved in inflammation are present at different levels in people with healthy gums, gingivitis, or periodontitis. Researchers will collect saliva, gum fluid, and gum tissue samples from 75 adults and measure the levels of these …

This study examined 318 adults to see if coffee drinking habits are linked to gum health. Participants were grouped by gum condition (healthy, gingivitis, or periodontitis) and asked about their coffee intake. Researchers measured plaque, bleeding, and gum pocket depth to find an…

This study tests whether ultrasound can map blood vessels in the lower jaw before gum recession surgery. Four adults with gum recession will receive a coronally advanced flap procedure, and researchers will compare ultrasound images taken before surgery with what they see during …

This study examined how standard non-surgical gum disease treatment changes the jaw bone structure in 69 people with gingivitis or periodontitis. Researchers used fractal analysis of dental X-rays taken before and 6 months after treatment to detect subtle bone changes. The goal i…

This study aims to discover new genes and mutations that cause isolated forms of amelogenesis imperfecta and dentinogenesis imperfecta—inherited conditions that affect tooth enamel and dentin. Researchers are using whole exome sequencing on participants who have these tooth disor…

This study looks at two different ways clear aligners are trimmed—one that sits on the gums and one that stops at the gum line—to see which leads to less plaque and healthier gums. Twenty adults with mild to moderate crowding will wear both designs at the same time (one on top, o…

This study investigates how gum disease—from mild gingivitis to severe periodontitis—affects specific proteins inside gum tissue cells that help control cellular cleanup and communication. Researchers will collect small gum samples from people with healthy gums, gingivitis, or pe…

This study looks at whether certain genetic variations (in COMT, MAOA, and SLC6A4) influence how well a standard dental numbing injection works for people with a painful tooth condition called irreversible pulpitis. Participants received a numbing shot and had their pain levels m…

This observational study investigates how different levels of gum health influence asprosin (a hormone) and total oxidant/antioxidant levels in people with type 2 diabetes. Researchers will collect fluid from around the gums and blood samples from 67 participants to compare these…

This study examines how different types of bacteria in the mouth are linked to the severity of dental cavities. Researchers will collect saliva and plaque samples from 56 people aged 3 to 45 and grade their cavities using a standard scoring system. The goal is to better understan…

This study follows head and neck cancer patients who received radiation therapy to see how many teeth they lose over two years. It also looks at other mouth problems like dry mouth and bone damage. The goal is to better understand and manage these long-term side effects.

This study looks at whether computer models can predict if local anesthetic (numbing) will work for people with a painful tooth condition called symptomatic irreversible pulpitis. Researchers analyzed records from 4,390 adult patients to compare three different machine learning a…

This study looked at 54 people with primary Sjögren's syndrome who also had muscle inflammation. Researchers wanted to see how many met the official criteria for inflammatory myopathies. The goal was to better understand and classify muscle disease in Sjögren's patients.

This study looked at whether certain amino acids in saliva differ between people with healthy gums, gingivitis, and periodontitis. Researchers also tracked how these amino acids changed after standard non-surgical gum treatment in 32 periodontitis patients. The goal is to see if …

This study tested three ways to teach oral hygiene to 72 teenagers with braces: verbal instructions, a pamphlet, or a video. Researchers measured plaque and gum health before and after to see which method worked best. The goal is to find the simplest, most effective way to help y…

This completed study looked at how oral health problems like cavities and gum issues affect the daily lives of 454 preschool children in Portugal. Researchers asked parents about their child's oral health and its impact on the child and family. The goal was to understand which so…

This study tested two types of magnetic attachments (flat vs. dome-shaped) for lower dentures held by implants. Fourteen adults with no teeth in their lower jaw took part. The goal was to see which design keeps dentures more securely in place.

This pilot study looked at bacteria in root canal infections, comparing painful and painless cases. Researchers used DNA testing to identify bacteria before and after cleaning with two different strengths of sodium hypochlorite. The goal was to see how well the cleaning removes b…

This study looked at 100 people with primary Sjögren's syndrome to understand how the disease affects their physical, emotional, and social well-being. Researchers used questionnaires and simple tests to measure symptoms like fatigue, pain, swallowing problems, and mood. A health…

This study looked at how repeatable and reproducible ADC maps are for measuring head and neck cancer in 58 adults. Participants had MRI scans using a standard method to see if results were consistent across different machines and sessions. The goal was to improve the reliability …

This study examined 180 adults to see if the shape of their gums and their oral habits (like brushing force or teeth grinding) are linked to non-carious cervical lesions — wear on teeth not caused by cavities. Participants filled out a questionnaire and had a dental exam. The goa…

This study examined whether women with autoimmune diseases or inflammatory rheumatism receive proper gynecological follow-up, including cervical cancer screening and contraception advice. Researchers surveyed 318 women with conditions like lupus, rheumatoid arthritis, and Sjögren…

This study looked at how the types of bacteria in an infected root canal change during routine dental treatment. Twenty-four adults with a chronic tooth abscess received standard root canal therapy using one of two bleach solutions (5.25% or 3% sodium hypochlorite) followed by a …

This study looked at whether a remote dental exam (teledentistry) can accurately assess treatment needs and behavior guidance for preschool children compared to a standard in-person exam. Researchers included 29 healthy children aged 4 to 6 years. The goal was to see if teledenti…

This completed study looked at 160 healthy adults to see if a blood test marker called Pan-Immune-Inflammation Value (PIV) is linked to the severity of gum disease. Researchers measured gum inflammation and compared it to PIV from routine blood work. The goal was to explore if th…

This study tested whether taking common painkillers like paracetamol or ibuprofen before a dental pulp sensitivity test changes the results. 184 healthy adults received either a painkiller or a placebo, and their tooth nerve responses were measured. The goal is to help dentists a…

This study looked at whether alcohol consumption affects the success of local anesthesia for people with a painful tooth condition called irreversible pulpitis. Researchers gave 70 patients (35 who drink alcohol and 35 who don't) a standard numbing injection and measured pain dur…

This study looked at how three types of dental crowns (stainless steel, zirconia, and fiber-glass) affect the gums of 21 children aged 6-9. Researchers measured gum pocket depth, bleeding, plaque, and inflammation markers in the gum fluid. The goal was to see which crown material…

This small study tested two methods for cleaning infected root canals: ultrasonic activation and a 980-nm diode laser. Sixteen adults with dead (necrotic) teeth had their root canals cleaned with one of these methods. Researchers checked for leftover bacterial DNA to see which me…

This study looked at 235 people to understand how certain immune cells, called innate T cells, might be involved in systemic sclerosis (a rare disease that causes hardening of the skin and organs). Researchers compared patients with systemic sclerosis to those with other autoimmu…

This study looks at proteins that help parts of cells communicate—specifically mitochondria and the endoplasmic reticulum—in people with healthy gums, gingivitis, or advanced gum disease. Researchers measure these proteins in saliva and gum fluid to see if they relate to inflamma…

This small study tested whether injecting a fluorescent dye called fluorescein sodium helps surgeons see nerves during head and neck surgery. Eight adults having open head or neck surgery received the dye through an IV. Surgeons then rated how well the glowing nerves matched stan…

This study looked at whether immune cells from the intestine play a role in Sjogren's syndrome, an autoimmune disease that causes dry eyes and mouth. Researchers examined saliva gland samples from 57 adults suspected of having Sjogren's. The goal was to better understand the dise…

This study looked at immune cells in a non-cancerous gum growth called peripheral giant cell granuloma (PGCG) and compared them to healthy gum tissue from the same 28 patients. Researchers used special staining to count different types of immune cells. The goal was to better unde…

This study looked at 36 adults with painful tooth nerve inflammation (irreversible pulpitis) to see if biological markers in gum fluid match symptoms. Researchers collected gum fluid samples before and after root canal treatment and measured pain levels. The goal was to find a li…

This study tested two ways of placing a flowable bulk fill composite in class II cavities (fillings between back teeth). 38 patients received two fillings each, one with the flowable composite exposed at the edge and one not. Researchers will check for restoration loss, staining,…

This study looked at 88 adults with chronic kidney disease to see how their oral health changes at different stages. Researchers checked teeth, gums, saliva, and breath to find links with nutrition and inflammation. The goal is to understand if dental problems can worsen kidney d…

This study looked at a rare disease called IgG4-related disease, which causes swelling and scarring in organs. Researchers compared immune cells in the blood of 75 people: those with the disease, those with Sjogren syndrome, and healthy volunteers. The goal was to better understa…

This study looked at whether training health workers and actively reaching out to smokers and heavy drinkers aged 35+ can get more of them to have a simple mouth exam for early oral cancer detection. Over 1,100 people from Rio de Janeiro's primary care clinics took part. The goal…

This study compared five different membranes used to preserve the jawbone after a tooth is pulled. Bone loss after extraction is common, and membranes help protect the area for future dental implants. Researchers measured bone changes and tissue quality in 47 adults who needed a …

This completed study looked at 227 people with HIV who are on antiretroviral therapy. Researchers examined their oral health—including cavities, gum disease, and dry mouth—and checked for links to metabolic problems and ongoing inflammation. The goal was to understand if poor ora…

This study looked at whether adding hands-on simulation training to standard classroom teaching helps nurses cause fewer problems when inserting needles into the arm access (arteriovenous fistula) of dialysis patients. About 9600 adults on chronic hemodialysis took part. The goal…

This completed study used artificial intelligence to examine electronic health records from 10,000 head and neck cancer patients. The goal was to create models that can predict the risk of cancer coming back or progressing, and to identify which patients might live longer after i…

This study tested whether custom-made orthodontic molar bands, created using digital scans and 3D printing, lead to better gum health than standard pre-made metal bands. 180 teenagers getting braces were randomly assigned to one type of band. Researchers checked plaque buildup, g…

This study looked at 24 people getting braces or clear aligners to see which leads to more early tooth decay (white spots and hidden cavities). Over 6 months, researchers checked teeth with visual exams and a special scanner. The goal is to help patients and dentists choose the s…

This completed trial compared two ways of preparing the bone for dental implants: a newer technique called osseo-densification, which compacts bone rather than removing it, and the standard conventional drilling method. Eight adults needing two implants each (16 total) received o…

This study looked at how dental students hold their bodies while doing root canal work. Ten students were recorded on video for 5 minutes, and their posture and muscle fatigue were analyzed. The goal was to understand how their working positions might lead to pain or injury. This…

This study looked at whether kissing can protect teeth from cavities. After drinking acidic beverages, one group kissed their partner for 40 seconds while a control group did not. Researchers measured saliva pH every 5 minutes to see if kissing helped neutralize acid faster. The …

This study looked at the types of bacteria in the mouth and the levels of a protective antibody in the saliva of children with autism, aged 6 to 18. Researchers collected dental plaque and saliva samples to compare with dental health. The goal was to learn more about oral health …

This study tested whether a microteaching approach improves nursing students' urinary catheterization skills and satisfaction compared to standard training. Sixty nursing students were randomly assigned to either microteaching or usual instruction. Researchers measured skill leve…

This study looked back at 420 patients who had jaw surgery after using either clear aligners or traditional metal braces. The goal was to see if the type of orthodontic preparation affected how smoothly the surgery went. Researchers checked things like how stable the jaw was duri…

This study looked at how often people with primary Sjögren's syndrome have digestive issues. Researchers asked 151 patients about 10 different digestive symptoms using a simple questionnaire. The goal was to understand which symptoms are most common and how they relate to how lon…

This completed trial tested a mobile app and web platform (BD4QoL) to monitor quality of life in 410 head and neck cancer survivors after curative treatment. The goal was to see if the platform could reduce or catch early declines in quality of life compared to standard follow-up…

This study compared two ways to remove cavities in children: using a laser or a traditional drill. Researchers measured how much cavity-causing bacteria (Streptococcus mutans and Lactobacillus) remained in the tooth after each method. The goal was to see if the laser could be a l…

This study followed 293 people with autoimmune diseases and healthy volunteers to see how COVID-19 infection or vaccination affects their immune system, inflammation, and blood vessels. Participants were grouped based on their COVID-19 history and had up to 5 visits over 12-18 mo…

This study measured levels of a protein called IL-36α in saliva and gum fluid from 80 people with gum disease, gingivitis, or healthy gums. The goal was to see if this protein is linked to gum inflammation and damage. No treatment was given; it was purely an observational study t…

This completed study surveyed 121 adults with autoimmune diseases like lupus, Sjögren's syndrome, or scleroderma. Participants filled out a questionnaire about their use of alternative medicines. The goal was to find out how common these practices are in this patient group.

This study measured certain inflammatory markers in the saliva and blood of 126 people with type 2 diabetes, some of whom also had kidney disease (diabetic nephropathy). The goal was to see if these markers differ based on gum health. Researchers hope to better understand the lin…

This study explored whether the Epstein-Barr virus (EBV) contributes to inflammation in oral lichen planus, a chronic mouth condition that can be painful. Researchers measured levels of EBV genetic material in 13 adults with the atrophic or erosive form of the disease. The goal w…

This study looked at 209 older adults (ages 50-70) taking blood pressure medication to see how many had cavities on the roots of their teeth. Researchers also checked saliva acidity and other risk factors. The goal was to understand if these medications are linked to root cavitie…

This study looked at a new way to transplant mature teeth that might help them regain blood supply. Researchers reviewed the outcomes of 16 people who had this procedure. The goal was to see if the teeth survived and if blood flow returned.

This early-phase study looked at whether a protein from the Maackia amurensis seed (MASL) can target a receptor called podoplanin found on oral cancer and precancerous cells. Researchers measured how much of this receptor was present in tissue samples from 18 adults with suspicio…

This study tested whether using a digital face scan to position a dental model saves time and reduces material removal when fitting a single crown, compared to digitizing a conventional articulator mount. Thirty-three adults needing a crown on a molar participated. The goal was t…

This study looked at whether a specific gene variation (SCN9A rs6746030) affects the success of numbing injections for root canal treatment. Researchers compared 200 patients with irreversible pulpitis who either had successful or failed anesthesia. By analyzing DNA from cheek sw…

This study measured two proteins, Dkk-1 and sFRP5, in the gum fluid of 99 people with healthy gums, gingivitis, or periodontitis. Researchers collected samples before and after non-surgical periodontal treatment (deep cleaning) to see if these proteins change with treatment. The …

This completed study from Saudi Arabia surveyed 100 adult denture wearers about their knowledge of denture care and oral probiotics. Participants also had a dental exam and provided plaque samples to check for bacteria and fungi. The goal was to see how awareness and practices re…

This study tests a French version of a questionnaire that measures how dentin hypersensitivity (sharp, brief tooth pain) affects people's daily lives. Researchers enrolled 216 adults across three centers in France, including people with different levels of sensitivity and a contr…

This study tested how much fluoride remains in saliva after using different toothpastes (over-the-counter or prescription) followed by either water or a fluoride mouthrinse. Twenty healthy adults tried four different combinations. The goal was to see which routine keeps fluoride …

This study explored whether how addicted a person is to nicotine affects their awareness of having gum disease. Researchers examined 350 smokers with gingivitis or periodontitis, measuring their nicotine dependence with a standard test and asking about their gum health. The goal …

This study looked for gene changes that might make children more prone to severe tooth decay. Researchers compared 390 young people with many cavities to cavity-free adults. They checked for mutations in genes that affect enamel, the hard outer layer of teeth. The goal is to unde…

This study looked at whether gum inflammation affects the genes that control the body's daily (circadian) clock. Researchers collected gum tissue from 60 healthy adults with similar sleep habits, comparing those with healthy gums, gingivitis, or advanced gum disease. They measure…

This study looked at whether measuring brain waves before a root canal can help predict how much pain a person will feel afterward. One hundred adults with tooth pain took part. Researchers recorded their brain activity at rest and then asked them to rate their pain after treatme…

This study looked at what parents and children prefer when it comes to filling cavities in baby molars. About 140 families shared their thoughts on different types of fillings, like stainless steel crowns and tooth-colored materials. The goal was to help dentists understand famil…

This study looked at 105 babies born to mothers who smoked during pregnancy, comparing those whose mothers quit versus those who continued. Researchers checked health indicators like birth weight, Apgar scores, and developmental milestones up to 24 months. The goal is to understa…

This observational study looked at 400 dental and medical students to see how their oral health affects their quality of life. Researchers measured plaque, gum health, and cavities, and asked students about their oral health-related well-being. The goal was to understand if diffe…

This study looked at whether measuring insulin in saliva can help identify children at risk for metabolic problems and cavities. Researchers gave 105 children aged 5-10 either water, apple juice, or nothing, and checked how their saliva insulin changed. The goal was to see if sal…

This completed study looked at 73 children aged 6-12 to see if sleep problems and certain chemicals in saliva are linked to cavities and gum health. Researchers measured things like saliva flow, pH, and stress hormones, and compared them to the severity of tooth decay. The goal w…

This study brings together 35 healthcare professionals from around the world to agree on the best methods for clearing mucus from the airways of intubated, critically ill patients. Using a Delphi process, experts will vote on statements about humidification, inhaled therapies, su…

This completed study measured two immune proteins, IL-8 and IL-10, in fluid from the gums and around the tooth root during root canal treatment. Researchers wanted to see how these levels change as treatment progresses in people with infected, dead tooth pulp. Twenty-two adults a…

This study tested whether using a laser for oral biopsies causes less pain and heals better than the standard punch scalpel in people with oral lichen planus. 112 adults were randomly assigned to one of the two methods. Researchers measured wound healing and discomfort after the …

This study looked at saliva from 21 people: some with oral lichen planus, some with oral leukoplakia, and some healthy. The goal was to see if proteins in saliva are different between these groups. Researchers hope these protein differences could one day help doctors tell these t…

This study looked at four different techniques for placing tooth-colored composite fillings in back teeth with cavities. Fifty patients received 200 fillings and were followed for 2 years to see how well the fillings held up, especially around the edges. The goal is to find the b…

This study looked at two different brands of stainless steel crowns used to fix cavities in children aged 2 to 8 years old. All children were treated under general anesthesia at a dental school. Researchers checked how well the crowns stayed in place and kept the gums healthy, an…

This study looked at how smoking changes saliva and whether it makes teeth more prone to erosion. Fifty healthy volunteers wore a small device in their mouth to collect saliva samples. Researchers then measured how much calcium was lost from tooth samples and analyzed the saliva'…

This study looked at the oral health of 61 obese adults, comparing those who had bariatric surgery to those who did not. Researchers measured tooth wear, cavities, and gum disease to understand how surgery might affect the mouth. The goal was to gather information, not to test a …

This study tested whether a mobile app designed for sick newborn care helps nurses in the Neonatal Intensive Care Unit (NICU) better recognize nursing diagnoses and reduce missed care. 64 nurses used the app for 3 months, while a control group continued routine care. Researchers …

This study looked at 100 people with gum disease, some also with obesity, to see how non-surgical gum cleaning affects the body's immune system. Researchers measured changes in inflammation and immune cells before and after treatment, comparing men and women. The goal was to find…

This study examined whether type 2 diabetes influences how well a dental procedure called pulpotomy works in adults. Researchers compared 70 diabetic and non-diabetic patients who had a molar treated for irreversible pulpitis. They checked the tooth's health, symptoms, and X-ray …

This study looked at 33 people who had surgery for oral or throat cancer and received a collagen patch (Tachosil) to help rebuild the area. Researchers asked patients to fill out questionnaires about their swallowing and voice the day before surgery, and again at 1 month and 6 mo…

This study looked at stem cells taken from two different areas of the gums (the front and back of the palate) to see which ones are better at forming bone and other dental tissues. Researchers collected gum tissue from 7 people and grew the cells in the lab to test their ability …