Sealants or varnish? study finds best way to protect Kids' new molars from decay

NCT ID NCT05969756

Completed Prevention Sponsor: Hue University of Medicine and Pharmacy Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested three early treatments—fluoride varnish, conventional sealant, and self-etch sealant—on 132 children's partially erupted permanent molars with early cavity signs. The goal was to see which best prevents cavities from forming or getting worse. Researchers tracked new cavities, sealant retention, and survival over time to find the most effective approach for protecting these vulnerable teeth.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Fluoride varnish, conventional etch-and-rinse sealant, self-etch sealant
What this could lead to: If successful, this could point to the best early treatment to prevent cavities in children's new permanent molars, reducing the need for fillings.
What could go wrong: This is a small, completed study (132 participants) comparing several treatments. Results may not apply to all children or other types of teeth, and long-term benefits are not yet confirmed.

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Conditions

The condition(s) this trial relates to.

dental caries pit and fissure surface dental caries

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARIES,DENTAL CARIES; INITIAL OCCLUSAL CARIES

Contacts and locations

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Locations

Hue University of Medicine and Pharmacy

Huế, Thừa Thiên Huế Province, 49120, Vietnam
Phu Vang Hospital

Phú Vang, Thừa Thiên Huế Province, 49900, Vietnam

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