Cure My Disease

Don't miss your cure!

 Log in / Sign up

Sealants or varnish? study finds best way to protect Kids' new molars from decay

NCT ID NCT05969756

Prevention Sponsor: Hue University of Medicine and Pharmacy Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested three early treatments—fluoride varnish, conventional sealant, and self-etch sealant—on 132 children's partially erupted permanent molars with early cavity signs. The goal was to see which best prevents cavities from forming or getting worse. Researchers tracked new cavities, sealant retention, and survival over time to find the most effective approach for protecting these vulnerable teeth.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Fluoride varnish, conventional etch-and-rinse sealant, self-etch sealant
What this could lead to
If successful, this could point to the best early treatment to prevent cavities in children's new permanent molars, reducing the need for fillings.
What could go wrong
This is a small, completed study (132 participants) comparing several treatments. Results may not apply to all children or other types of teeth, and long-term benefits are not yet confirmed.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

132 people

The number who actually took part.

Started

Jul 2023

Finished

Oct 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

5 to 14 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: For children: 1. Children presenting with good general health and cooperative behavior. 2. Children having early caries lesions in a permanent molar (first or second). 3. Parents signed informed consent. For permanent molars: 1. Early caries lesions on the occlusal surface corresponding to International Caries Detection and Assessment System (ICDAS) scores 1 and 2. \[Ismail AI, Sohn W, Tellez M, Amaya A, Sen A, Hasson H, Pitts NB. The International Caries Detection and Assessment System (ICDAS): an integrated system for measuring dental caries. Community Dent Oral Epidemiol. 2007 Jun;35(3):170-8\]. 2. Erupting molars: eruption stages 2 (fully erupted occlusal surface with less than half of the crown exposed) and 3 (fully erupted occlusal surface with more than half of the crown exposed). \[Carvalho JC, Ekstrand KR, Thylstrup A. Dental plaque and caries on occlusal surfaces of first permanent molars in relation to stage of eruption. J Dent Res. 1989 May;68(5):773-9\]. Exclusion Criteria: For children: 1. Any allergy reported by the parents. 2. Children unable to return for recall visits. For permanent molars: 1. Teeth with occlusal surfaces completely covered by the gingival tissue. 2. Teeth with hypoplastic defects, restorations, or sealants.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Caries,dental are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

dental caries pit and fissure surface dental caries

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Caries,dental Caries; initial Occlusal caries

Contacts and locations

Locations

  • Hue University of Medicine and Pharmacy

    Huế, Thừa Thiên Huế Province, 49120, Vietnam

  • Phu Vang Hospital

    Phú Vang, Thừa Thiên Huế Province, 49900, Vietnam

More trials for these conditions

Other studies related to the condition(s) this trial covers.