Cure My Disease

Don't miss your cure!

 Log in / Sign up

Could a probiotic tame your canker sores?

NCT ID NCT02789605

Disease control Sponsor: Centre Hospitalier Universitaire de Nice Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether a probiotic called Lactobacillus rhamnosus Lcr35® can reduce the number of painful canker sores in people who get them often. Twenty adults with frequent outbreaks took either the probiotic or a placebo daily for 3 months, then were monitored for another 3 months. The goal was to see if the probiotic could safely lower the number of sores and improve quality of life.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Lactobacillus rhamnosus Lcr35® (a probiotic)
What this could lead to
If it works, this could point toward a simple, safe probiotic treatment to reduce canker sore outbreaks.
What could go wrong
This is a very small, early-phase trial (20 participants) with no published results yet. The benefit may be small or no better than placebo.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

20 people

The number who actually took part.

Started

Jan 2018

Finished

Jul 2020

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 18 year-old or more * Recurrent idiopathic aphtous stomatitis with at least one new lesion per month during the past 6 months. Exclusion Criteria: * Symptomatic aphtosis associated with Crohn or Behcet disease * Concomitant use of probiotic for any other reason * Systemic use of colchicine or steroids or immunosuppressive drugs during the past 3 months

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Aphthous stomatitis are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

aphthous stomatitis canker sore

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Aphthous stomatitis

Contacts and locations

Locations

  • CHU de NIce - Dermatologie

    Nice, Alpes-Maritimes, 06200, France