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Gene hunt: could your Child's DNA predict severe tooth decay?

NCT ID NCT00541060

Knowledge-focused Sponsor: Assistance Publique - Hôpitaux de Paris Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked for gene changes that might make children more prone to severe tooth decay. Researchers compared 390 young people with many cavities to cavity-free adults. They checked for mutations in genes that affect enamel, the hard outer layer of teeth. The goal is to understand why some kids get severe cavities even with good dental care.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help identify children at high risk for severe cavities, leading to better prevention and treatment strategies.
What could go wrong
This is an early genetic study, not a treatment trial. It may not find clear links, and results may not apply to all populations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

390 people

The number who actually took part.

Start date

Oct 2007

Finished

Nov 2009

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

2 to 30 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients : presenting at least 3 active carious lesions aged 2 to 16 years old, written informed consent * Volunteers : young adults 18 to 30 years old totally caries free Exclusion Criteria: * patients with systemic or enamel pathologies such as amelogenesis imperfecta * osteogenesis imperfecta * hypophosphatemia * hypodermal dysplasia * syndrome of Prader Willi * Fluoroses * toxic enamel dysplasia * pregnancy or breast-feeding * HYPOSIALORRHEA * immunodepression status * chronicle diseases * anorexia or bulimia

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Conditions

The condition(s) this trial relates to.

dental caries

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Dental caries

Contacts and locations

Locations

  • Hopital Bretonneau

    Paris, 75018, France

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