Mouth disorder

This phase 3 trial tests whether adding sintilimab, an immunotherapy drug, to chemotherapy before surgery helps people with early-stage oral squamous cell carcinoma. Participants are adults aged 18 to 75 with cT2N0M0 oral cancer that can be removed by surgery. Half receive sintil…

This phase 2 trial is testing whether giving two drugs before surgery can help people with advanced oral cavity cancer. The drugs, becotatug vedotin and pucotenlimab, are designed to attack cancer cells and boost the immune system. Participants receive three cycles of the combina…

This phase 1 trial is testing an experimental drug called ATG-201 in adults with systemic lupus erythematosus, systemic sclerosis, or Sjögren's disease. ATG-201 is designed to bind to specific proteins on immune cells, potentially quieting the overactive immune response that driv…

Dentists often replace a failed filling in a baby tooth by drilling it out and starting over. This trial tests a gentler option: repairing just the broken part and leaving the healthy filling in place. Researchers will assign 824 baby molars from children aged 4 to 8 to either re…

This study tests a new drug called SX-682 (a tablet) combined with the chemotherapy docetaxel in people whose head/neck, salivary gland, or prostate cancer has spread or returned after treatment. The goal is to find the right dose and see if the combination shrinks tumors. About …

Researchers test whether coconut oil pulling or a moringa mouthwash can reduce gingivitis in children with diabetes, compared with chlorhexidine. Thirty children aged 6 to 12 with mild to moderate gingivitis use one of the three rinses. The team measures gum inflammation and leve…

Researchers test whether a rinse made from frankincense (Boswellia sacra) removes bacteria from infected root canals as well as the standard sodium hypochlorite rinse. Thirty adults aged 18 to 50 with a dead or infected tooth take part. Each person is randomly assigned to one of …

Researchers are testing an experimental antibody called JH013 in adults with primary Sjögren's syndrome, a condition where the immune system attacks moisture-producing glands and other tissues. The trial has two parts: one gives a single injection at increasing doses, and the oth…

Researchers are testing whether a toothpaste containing isopropyl methyl phenol reduces plaque buildup and gum bleeding better than a regular fluoride toothpaste. The 12-week study enrolls 120 Chinese adults with plaque-induced gingivitis. Dentists measure gum bleeding at weeks 2…

Researchers are testing whether adding rimegepant to standard chemoimmunotherapy before surgery helps shrink oral or oropharyngeal squamous cell carcinoma more effectively. The trial enrolls adults with primary or recurrent disease who are scheduled for surgery. Participants rece…

Researchers in Oman are testing whether a structured education program that combines diabetes and oral health advice can improve blood sugar control and gum health in adults with type 2 diabetes. The trial enrolls 290 adults aged 35 and older who have had type 2 diabetes for at l…

This trial tests whether a one-bottle or a two-bottle HEMA-free dental adhesive works better for filling cavities on the front surfaces of teeth. About 50 adults with early to moderate cavities will receive a filling using one of the two adhesives. Researchers will check how well…

This trial tests whether adding injectable platelet-rich fibrin (i-PRF) or hyaluronic acid gel to standard free gingival graft surgery improves healing and reduces graft shrinkage. Adults with gum recession and insufficient keratinized tissue will be randomly assigned to one of t…

This study tests whether using an electric flosser along with a manual toothbrush and fluoride toothpaste reduces plaque and gum inflammation more than brushing alone. About 80 adults with mild gum disease will follow one of two routines for 30 days. Researchers will measure chan…

This trial compares two ways to treat tooth decay at the gum line in elderly cancer patients. One method uses a silver solution to stop decay without drilling, then places a filling. The other uses the traditional approach of drilling out the decay before filling. The study will …

This case series tests a new device called the Sublingual Neonatal Incision Platform (SNIP) for releasing tongue-tie in infants. The study enrolls six infants with anterior ankyloglossia who need intervention. Clinicians will rate how intuitive the device feels and whether they w…

This trial gives deucravacitinib, an oral drug that calms the immune system, to adults with lupus or Sjögren's disease and to children with psoriasis or psoriatic arthritis. Participants join after finishing an earlier study of the same drug, and the goal is to see how safe and t…

This Phase 3 trial tests whether a multi-component oral hygiene regimen, including specific mouthwashes and toothpaste, improves outcomes in adults with stage II periodontitis undergoing non-surgical periodontal treatment. Participants will use either an active regimen or a place…

This trial tests whether a modified gum graft technique, called a vertically coronally advanced flap, covers exposed tooth roots better than the standard coronally advanced flap. Both methods use a connective tissue graft to thicken the gum. Researchers will measure how much the …

This trial tests two resin infiltration systems, ICON and I-Mate, to see which better masks white spot lesions on front teeth and matches the natural tooth color. Researchers will enroll 50 people aged 16 to 35 who have non-cavitated white spots, often from previous braces. Parti…

This early-stage study tests whether a single infusion of a patient's own modified immune cells (CAR-T cells) is safe for people with severe autoimmune diseases like lupus, rheumatoid arthritis, or scleroderma that haven't improved with standard treatments. Only 6 adults aged 18-…

This study tests whether one or two applications of 38% silver fluoride can stop cavities in the baby teeth of children aged 4 to 6 years. Researchers compare a single treatment against two treatments given three months apart, and also measure how the children's oral health affec…

This phase 2 trial tests a combination of two drugs, XL-092 and pembrolizumab (Keytruda), given before surgery to people with a type of oral cancer that is HPV-negative and can be removed. The goal is to see if the drugs can shrink or eliminate the tumor before the operation. Abo…

This study looks at how well children regain their chewing strength after getting a crown on a decayed baby molar. It compares two types of crowns: a newer BioFlx crown and the standard stainless-steel crown. Thirty children aged 5 to 8 with tooth decay will receive one of these …

This trial compares two minimally invasive ways to treat cavities in children's back baby teeth. The standard Hall Technique seals the cavity with a stainless steel crown, without drilling or numbing. The SMART Hall technique adds a silver diamine fluoride (SDF) coating before se…

This trial tests two tooth-colored filling materials for cavities between the back baby teeth of children aged 4 to 7. One filling is a zirconia-fortified glass ionomer, and the other is a resin-modified glass ionomer. Dentists will place the fillings after removing decay and the…

This study compares two materials used in gum graft surgery for people with thin or missing gum tissue around teeth or dental implants. One group receives a graft made from their own palate tissue, while the other group receives a graft made from a collagen matrix derived from pi…

This phase II trial is testing whether adding a special type of radiation therapy to the immunotherapy drug pembrolizumab before surgery can help shrink oral cavity tumors. The study compares two radiation techniques: proton spatially fractionated radiotherapy (SFRT), which deliv…

This study tests whether a special collagen matrix can replace tissue taken from the roof of the mouth to fix receding gums. Forty adults with at least two areas of gum recession will receive either the collagen matrix or a standard palate graft. The main goal is to see how much …

This phase II trial is testing whether combining a TROP-2 antibody-drug conjugate (sacituzumab govitecan or sacituzumab tirumotecan) with the immunotherapy drug toripalimab can shrink tumors in people with resectable, locally advanced oral squamous cell carcinoma. Participants re…

This trial tests whether adding a gel made of hyaluronic acid and polynucleotides to standard gum graft surgery helps cover receding gums better. Twelve people with receding gums will receive the surgery with the gel applied to the graft. Over six months, the study measures how m…

This study looks at two different approaches to help pregnant people with gum disease get better dental care. Participants will receive free dental check-ups, cleanings, and supplies. The goal is to see which method reduces gum inflammation and improves oral health habits, and wh…

This study is testing a mouth rinse made from stingless bee honey as a gentler alternative to standard chemical mouthwashes for gingivitis (gum inflammation). Researchers will develop the rinse, check its safety and germ-fighting power in the lab, then test it in 20 volunteers to…

This trial tests whether daily use of a botanical mouthwash for 14 days can improve gum health in healthy adults. Researchers compare two proprietary botanical blends, a combination of both, and a placebo rinse. They measure gum inflammation, dry mouth symptoms, and changes in th…

This phase 2 trial is testing whether combining the immunotherapy drug pembrolizumab with a short course of high-dose radiation, with or without additional radiation to nearby lymph nodes, can shrink or eliminate head and neck tumors before surgery. Adults with resectable squamou…

This trial tests two different pastes—calcium hydroxide-iodoform and a modified triple antibiotic—used in a procedure called LSTR to treat severely infected baby molars in children aged 4 to 7. The goal is to see which paste better stops infection, relieves pain, and preserves th…

This study tests whether a procedure called full pulpotomy can successfully treat permanent teeth with irreversible pulpitis and apical periodontitis. Instead of removing the entire nerve like a root canal, full pulpotomy removes only the inflamed pulp from the crown, preserving …

This trial asks whether it is safe to skip the routine removal of impacted teeth before radiation therapy for nasopharyngeal carcinoma. Half of the participants will have the extraction as usual, while the other half will not. The study will compare the risk of jaw bone damage (o…

This trial compares two types of clear retainers worn after braces to see if the way they are made affects gum health. One retainer is created from a digital scan of the teeth, while the other uses a traditional plaster mold. About 52 people who recently finished braces will wear…

This trial asks whether a minimally invasive root canal procedure can match the success of the traditional approach in treating lower molars with dead nerves and an infected root tip. Sixty adults aged 20 to 50 with such molars will be randomly assigned to receive either a conser…

This study tests a combination of an experimental drug (ficerafusp alfa), an immunotherapy (pembrolizumab), and targeted radiation before surgery for people with advanced head and neck cancer that is HPV-negative. About 45 participants will receive these treatments over several w…

This trial tests whether an experimental drug called efgartigimod can reduce nerve damage and pain in adults with Sjogren's disease. Participants will receive either the drug or a placebo as a subcutaneous injection. The study measures changes in neuropathy symptoms and quality o…

This trial tests whether giving two immunotherapy drugs—pembrolizumab and cetuximab—before surgery can shrink advanced oral cancers linked to betel-nut chewing. The study enrolls 20 people in the Northern Mariana Islands who have not yet received treatment. Researchers will measu…

This early-stage trial is evaluating an investigational drug called QLS2404, given as an injection, to see if it is safe and tolerable. The study first tests single doses in healthy volunteers, then moves to multiple doses in people with systemic lupus erythematosus or primary Sj…

This trial tests whether extra follow-up—via phone calls, digital messages, or both—helps people recover better after a tooth extraction. Adults having a tooth pulled will get standard instructions, and some will also receive structured phone or digital check-ins during the first…

This Phase 2 trial tests whether a topical drug called KH001 can preserve the pulp (nerve) inside teeth with deep cavities. Adults with deep dentinal caries will receive either KH001 or a placebo applied to the cavity. The study tracks how many people develop irreversible pulpiti…

This trial tests whether cold atmospheric plasma can match standard sodium hypochlorite irrigation for disinfecting root canals in teeth with dead nerves. Sixty adults with a single necrotic tooth will receive one of the two treatments. Researchers will compare post-treatment pai…

This trial compares two types of zirconia crowns—custom-made versus prefabricated—for restoring severely decayed baby molars after a pulpotomy (a procedure to save the tooth). Children aged 5-8 with deep cavities in their primary molars will receive one of the two crowns, and res…

This study will test if a toothpaste with stannous fluoride can reduce bacteria on teeth, tongue, cheeks, and gums better than a regular toothpaste. About 100 adults with plaque and gingivitis will brush with one of the two toothpastes. The goal is to see which one controls bacte…

This trial compares two methods for removing black tooth stains in children aged 4 to 13. After an initial ultrasonic cleaning, one group receives a standard polish with paste and brush, while the other gets an air-polishing treatment using erythritol powder. Researchers will tra…

This phase 2 trial is testing whether an oral drug called ICP-488 can reduce disease activity in people with primary Sjögren's syndrome, an autoimmune condition that causes dry eyes, dry mouth, and fatigue. About 240 adults aged 18 to 70 with moderate-to-active disease will recei…

This trial tests whether adding a clinical pharmacist to dental care can improve how oral mucosal disorders — such as oral lichen planus, recurrent canker sores, burning mouth syndrome, oral thrush, and herpes infections — are managed. Dentists in some clinics will get pharmacist…

This study compares two ways to handle severely decayed front baby teeth in children aged 3 to 5: restoring them with zirconia crowns or simply extracting them. Researchers want to see which approach leads to better quality of life, parental satisfaction, child self-image, and sp…

This study tests whether a new, chlorhexidine-free mouthwash can reduce plaque buildup, gum inflammation, and bad breath in children aged 12 to 17 who wear fixed metal braces. Participants rinse twice daily for 21 days alongside their usual brushing and flossing. The trial compar…

This early-phase trial tests a single dose of universal (off-the-shelf) CAR-T cells in 30 adults with active autoimmune diseases like lupus, scleroderma, vasculitis, myositis, or Sjögren's. The treatment targets CD19 and BCMA on immune cells to reset the faulty immune system. The…

This trial compares a standardized siwak (chewing stick) oral hygiene program to conventional toothbrushing for improving gum health in young adults with gingivitis. Participants are dental students aged 18–24 who will follow either the siwak module or toothbrushing for 21 days. …

This study compares toothpaste tablets to a standard toothpaste (Colgate Cavity Protection) for cleaning teeth and gums. Fifty adults will use one of the two products for six weeks. Researchers will measure plaque, gum inflammation, and cavities before and after the trial to see …

This trial tests a new toothpaste containing a Bio-Descaling Powder (BDP) to see if it can reduce hardened dental plaque (calculus) and gum inflammation. It includes 100 adults with gum disease or who are in a gum maintenance program. Participants brush with either the BDP toothp…

This study looks at whether using a miswak stick—a natural teeth-cleaning twig—along with regular brushing can improve gum health in people with gingivitis. Researchers will measure markers of inflammation and oxidative stress in saliva and plaque. The goal is to see if this trad…

This study tests whether amla (Emblica officinalis), a medicinal plant, can replace standard sodium hypochlorite as a disinfectant during root canal treatment. The trial includes 66 people aged 18–50 with infected single-rooted front teeth. Researchers measure how well each solut…

This phase 2 trial tests the drug zanzalintinib in people whose adenoid cystic carcinoma (a rare salivary gland cancer) has returned or spread. Despite initial surgery and radiation, about half of patients experience recurrence, and current treatments offer limited benefit. Parti…

This study compares two dental filling materials for cavities that form near the gum line (cervical lesions). One is a self-hardening composite, the other a flowable composite. Fifty adults will receive one of the two fillings and be checked over 18 months to see which stays in p…

This large Phase 3 trial is testing a new drug called APG-157, given as a pastille that dissolves in the mouth, for people with advanced head and neck cancer. The study will see if adding APG-157 before and after standard treatments (surgery or chemoradiation) helps keep the canc…

This trial compares two types of rotary files designed for children's primary molars: Fanta AF Baby and EndoArt Pedo Blue. The goal is to see which system prepares root canals faster and with better filling quality during a pulpectomy (removing infected pulp). Thirty children age…

This study investigates how bacteria that cause tooth decay and gum disease spread among family members. Researchers will treat either the child alone, the child and parents, or all family members with professional dental cleaning. They will track bacterial transmission using DNA…

This study tests whether oxymetazoline, a common nasal decongestant, can replace sodium hypochlorite as a bleeding control agent during pulp treatment in children's baby teeth. About 50 Egyptian children aged 4-8 with decayed molars will receive either treatment. The goal is to s…

This phase 2 trial tests whether eye drops containing infliximab, a drug that blocks a key inflammatory protein, can safely improve severe dry eye in people with Sjögren's syndrome. 38 adults will receive either the active drops or a steroid drop for 6 weeks. The study measures s…

This study tests whether a hyaluronic acid mouthwash is more acceptable to children than a standard chlorhexidine mouthwash, while still controlling plaque-induced gingivitis. Thirty-two children aged 8 to 12 with signs of gingivitis will use one of the two mouthwashes. Researche…

This study compares 3D-printed resin crowns to standard stainless steel crowns for children's back teeth that have had pulp treatment. Twenty-six children aged 4 to 8 will receive one type of crown and be followed for a year. The goal is to see if the 3D-printed crowns lead to he…

This study compares two types of computer-designed and milled inlays—hard hybrid ceramic and resin composite—for repairing large cavities in vital back teeth. Fifty healthy adults aged 16 to 50 with a single molar needing a large filling will receive one of the two inlays. Resear…

This first-in-human study tests the safety of a new drug called HBM7020. It will first be given to healthy volunteers at low doses, then to people with moderate to severe autoimmune diseases like lupus, rheumatoid arthritis, scleroderma, and Sjögren's disease. The goal is to see …

This early-phase trial tests whether specially engineered immune cells (NK cells) can safely treat high-risk precancerous spots in the mouth. The cells are injected directly into the lesions and are designed to target a protein called TROP2, while also resisting signals that norm…

This early-stage study tests a new injection called CM336 in 30 adults with active Sjogren's syndrome. The main goal is to check safety and how the body handles the drug. Researchers will also look for signs that it helps control the disease. This is a Phase 1 trial, so it's one …

This study compares two ways of making dental crowns for back teeth that have had root canals: 3D-printing from a ceramic-filled resin versus milling from a ceramic block. Sixty adults will receive one of these crowns and be checked for fractures, fit, and color over two years. T…

This study compares two treatments for severely damaged lower molars: a tooth-saving surgery called hemisection (removing the damaged root) versus replacing the whole tooth with a dental implant. Researchers will track 28 participants over 12 months to see which option leads to b…

This study tests whether applying a thin, clear surface sealant over tooth-colored fillings helps prevent discoloration and improves how long the filling lasts. Twenty-five adults with cavities in their back teeth will receive either a sealant or standard polishing. Researchers w…

This study tests whether a paste made from Salvadora persica (a plant used in traditional toothbrushes) mixed with zinc oxide can work as well as the standard material (MTA) for treating severe tooth inflammation. The trial involves 78 adults aged 18-40 with infected permanent mo…

This study tests whether a new experimental effervescent tablet can clean removable partial dentures better than a commercial cleanser or water. Fifteen adults with denture stomatitis will wear dentures with small material discs to collect plaque, then soak them daily in one of t…

This study compares two types of tonsil surgery for adults with obstructive sleep apnea and enlarged tonsils. One surgery removes the tonsils completely, while the other removes only part of them. The goal is to see if the less invasive approach works just as well at improving br…

This early-phase trial tests an injection called KSVCBD, a type of CAR-T cell therapy, in 60 adults with severe autoimmune diseases like lupus and scleroderma. The goal is to see if it's safe and to get a first look at whether it might help control the disease. Participants recei…

This study looks at three types of dental cement used to attach zirconia crowns to young children's front teeth. About 120 healthy kids aged 2 to 7 with decayed or injured teeth will get crowns and be checked for up to 3 years. The goal is to see which cement holds the crown best…

This study compares rosemary extract to a standard material (MTA) for treating severe tooth pulp inflammation. Researchers will treat 100 adults with a damaged tooth, placing either rosemary extract or MTA directly on the pulp. They will then measure pain and healing over time to…

This study compares two treatments for severely damaged upper molars: root amputation (removing only the damaged root and keeping the rest of the tooth) versus replacing the whole tooth with a dental implant. Researchers will track pain, bone healing, and implant stability over 1…

This study tests if a new bioactive varnish can fix white spot lesions on teeth better than standard fluoride varnish. About 60 people aged 16-35 with at least four white spots will get one of the two varnishes. Researchers will check how well the spots heal and if tooth color im…

This study tests whether a robot can place dental implants more accurately than a computer-guided navigation system in the front upper jaw. Twenty-four adults needing an implant will be randomly assigned to one of the two methods. The main goal is to see which approach achieves b…

This study tests whether a cream made from phenytoin, a seizure drug known to cause gum overgrowth, can help receding gums grow back. Thirty adults who want to avoid surgery will apply either the phenytoin cream or a placebo paste. Researchers will measure changes in gum attachme…

This study compares two types of dental fillings for cavities in the back teeth. Researchers will test a bulk-fill flowable resin against a submicron hybrid resin in 25 patients over 18 months. The goal is to see which filling performs better in terms of shape, comfort, and appea…

This study looks at how much denture teeth wear down over two years in people who have no natural teeth. It compares three types of teeth made with modern digital methods: 3D-printed, milled from a block, and standard prefabricated ones. The goal is to see which type resists wear…

This phase II trial tests a combination of an antibody-drug conjugate (a targeted cancer drug) and stereotactic body radiotherapy (precise, high-dose radiation) in 40 people with recurrent or metastatic salivary gland cancer. Participants first receive the drug; if their disease …

This study compares a new, simpler treatment called CTZ paste against the standard root canal procedure for infected baby teeth in emergency settings. The CTZ paste is placed directly into the tooth without drilling or cleaning the root canals, aiming to kill bacteria and save th…

This pilot study tests whether a gel made from a special form of hyaluronan (HA35) can help people with mild gum recession and chronic gum inflammation. Thirty adults will apply the gel to their gums and teeth twice a day for 42 days. Researchers will measure changes in gum reces…

This study tests a new type of tooth filling that sticks to the tooth without needing a separate bonding step. Researchers will compare it to the standard filling method in 75 adults with small to moderate cavities near the gum line. The fillings will be checked over 18 months fo…

This study compares three types of dental fillings—bioactive, nanohybrid, and bulk-fill—for treating cavities between teeth. Sixty adults with at least three cavities will receive each type of filling and be monitored for up to four years. The goal is to see which material holds …

This study will test a new injectable tooth filling material against a standard one for fixing cavities between baby molars in children aged 3 to 8. Fifty kids will get one of the two fillings, and dentists will check how well they hold up over a year. The goal is to see which fi…

This study compares mustard gel, made from black mustard seeds, to a standard dental material (MTA) for treating deep cavities in baby molars. 72 children aged 6-8 will receive one of the two treatments after the damaged nerve is removed. The goal is to see if mustard gel can kee…

This study will compare two treatments for cavities in children's back baby teeth. One uses a new injectable bioactive filling material, and the other uses the Hall Technique (placing a metal crown without drilling). About 50 children aged 3-8 with moderate cavities will be follo…

This study tests whether giving two drugs together before surgery can shrink advanced mouth or throat cancers. The drugs are becotatug vedotin and pucotenlimab. About 26 people with stage III or IVa cancer will take part. The goal is to see if the cancer nearly or completely disa…

This study tests whether using plaque-disclosing dyes (like erythrosine) with a special light can kill more cavity-causing bacteria in children aged 3 to 7 years. Seventy-two kids at high risk for cavities will get either standard dental cleaning or cleaning plus the dye-and-ligh…

Gum recession exposes tooth roots, causing sensitivity and cosmetic concerns. Standard surgery (CAF + SCTG) covers the root, but healing can be slow. This trial tests whether adding a hyaluronic acid gel (hyaDENT BG®) to the surgery improves root coverage and recovery. Thirty-fou…

This study compares two types of tooth-colored fillings—injectable and packable—for cavities in children's back baby teeth. Researchers will check how well each filling holds up over time using dental exams and X-rays. The goal is to see if the injectable type, which may be easie…

This study tests whether adding cross-linked hyaluronic acid through microneedling after gum surgery can improve gum thickness and cover exposed tooth roots better than microneedling alone. It involves 22 adults with a single gum recession and thin gums. Participants will receive…

This Phase 3 trial will test whether a toothpaste containing chitosan, a natural substance, can reduce plaque, gingivitis, and gum bleeding better than a standard fluoride toothpaste. About 90 adults aged 18-70 with good general health will brush with either the chitosan toothpas…

This early-phase study tests a new treatment called BEN301, which uses specially engineered immune cells (CAR-Tregs) to calm overactive immune responses in people with autoimmune diseases like scleroderma, rheumatoid arthritis, lupus, and inflammatory muscle disease. The trial wi…

This study will compare Bioflx crowns (a newer, tooth-colored material) with standard stainless steel crowns for children aged 6 to 9 who have had pulp treatment on their back baby teeth. The goal is to see how each crown affects bite force and the space between teeth, and how sa…

This study tests three special dental cements—Bio C Repair, Biodentine, and MTA—as treatments for irreversible pulpitis (nerve infection) in children's permanent molars. Sixty kids aged 6-10 will receive one of the materials after removing the infected pulp. The goal is to see wh…

This study tests whether giving the immunotherapy drug nivolumab before surgery can shrink tumors in people with advanced oral cancer. About 60 adults with resectable oral squamous cell carcinoma will receive nivolumab, then have surgery. Researchers will also look for biomarkers…

This study will test four different dental filling materials in 92 children aged 4-8 who have cavities in their baby molars. The fillings include newer materials like Cention N and Stela, as well as standard options like Beautifil II and resin-modified glass ionomer. Researchers …

This study tests whether a mixed reality system, similar to video game technology, can help surgeons remove oral cancer and rebuild the area more accurately. Thirty people with oral cancer will be split into three groups: one using mixed reality, one using a virtual surgical guid…

This study tests whether an antibiotic paste (LSTR) works as well as the standard filling (ZOE) for treating infected baby molars in children aged 4 to 10. 180 kids will be randomly assigned to one treatment and checked after 6 months for healing. The goal is to find a simpler, e…

This study tests whether thalidomide can reduce or stop fever episodes in children with PFAPA syndrome, a condition causing repeated fevers and sore throats. About 106 children aged 3 to 18 will take either thalidomide or colchicine daily for 6 months. Researchers will track how …

This study tests whether a single rotary file system removes more bacteria from infected baby molars than traditional manual files. Thirty-four children aged 4 to 6 with irreversible pulpitis will have their root canals cleaned using one of the two methods. The main goal is to me…

This study tests a low-cost approach to treat pre-cancerous and cancerous mouth lesions using a drug (5-ALA) that makes abnormal cells sensitive to light, followed by laser light delivered through a handheld device. The goal is to destroy these lesions without surgery. The trial …

This study looks at people with advanced mouth or throat cancer who had chemotherapy and immunotherapy before surgery. After surgery, they will either get radiation, immunotherapy maintenance, or just be watched. The goal is to see which approach helps them live longer without th…

This study compares two methods of moving canine teeth after premolar extraction: one with a minor surgical procedure (corticotomy) to speed movement, and one without. Sixty patients aged 12–30 will have their root length measured before and after treatment to see which method ca…

This study tests a new material made from treated dentin and calcium silicate for treating deep cavities that have reached the tooth's nerve. The goal is to see if it can keep the nerve healthy better than the current standard material. Fifty-six people aged 14 to 35 with deep ca…

This study tests two non-surgical treatments for oral leukoplakia, a white patch in the mouth that can turn into cancer. One treatment uses a light-activated dye (photodynamic therapy) and the other uses a vitamin D-based cream (calcipotriol). The goal is to see which works bette…

This study will test whether 3D-printed fillings work as well as standard bulk-filled resin ones for large cavities in back teeth. About 50 adults aged 22 to 45 with deep decay in a molar will receive one of the two filling types. Researchers will check the fillings' strength, fi…

This early-stage trial will test a new cell therapy called YTS109 in 12 children aged 5 to 17 with severe autoimmune diseases like lupus or scleroderma that have not responded to standard treatments. The children will receive a single infusion of these cells, and researchers will…

This study tests a new material called NeoPutty MTA against a standard chemical, formocresol, for treating deep cavities in children's back baby teeth. About 68 kids aged 4 to 9 will get one of the two treatments to save the tooth and prevent pain or infection. Researchers will c…

This study looks at how well a new type of dental filling (bioactive restorative system) works in people with controlled diabetes compared to those without diabetes. Fifty adults needing a filling in a back tooth will be followed for 18 months. Researchers will check for discolor…

This study tests whether graphene oxide can successfully treat decayed baby teeth that need pulp therapy. 126 children will be split into groups receiving graphene oxide, standard materials like MTA or zinc oxide, or a lesion sterilization technique. The goal is to see which appr…

This study tests whether heating sodium hypochlorite (a common disinfectant) inside root canals of dead teeth can kill more bacteria and reduce pain afterward. Thirty-six adults with a single dead tooth will receive one of two heating methods or standard cleaning. Researchers wil…

This study compares two treatments for irreversible pulpitis, a condition causing severe tooth pain. The standard treatment is a root canal, but researchers want to see if a less invasive procedure called pulpotomy works just as well. The study will involve 138 people and also lo…

This study tests if a less invasive procedure called partial pulpotomy using CGF (a blood concentrate) can control pain and inflammation in severely decayed permanent molars as well as standard root canal treatment. It will involve 60 adolescents aged 11-17 with intense tooth pai…

This Phase 3 trial tests whether giving a short course of targeted radiation (SBRT) followed by chemotherapy and immunotherapy before surgery can improve outcomes for people with advanced oral or HPV-negative throat cancer. About 184 participants will be randomly assigned to rece…

This phase 2 trial tests whether giving a combination of the immunotherapy drug camrelizumab and two chemotherapy drugs (paclitaxel and carboplatin) before surgery can improve outcomes for people with advanced oral cavity or larynx cancer. Fifty participants will receive three cy…

This Phase 2 trial tests an experimental drug called ESG206 in 40 adults with primary Sjögren's syndrome, an autoimmune disease causing dry eyes and mouth. The drug targets a protein to reduce immune system attacks on the body. Researchers will compare high and low doses against …

This study tests two cavity-stopping liquids in 60 children aged 3-5 with active tooth decay. One is a well-known treatment that turns cavities black; the other is a newer version that may avoid staining. Researchers will check which works better over 12 months, and ask parents a…

This study tests whether a mouthwash made from moringa leaves can reduce dental plaque, bacteria, and early cavities as well as the standard chlorhexidine rinse. Researchers will enroll 90 adults with mild gum inflammation and moderate-to-high cavity risk. Participants will use e…

This early-phase study tests a new type of radiation (lattice radiotherapy) given with chemotherapy and immunotherapy before surgery for oral cavity cancer. About 30 adults with advanced but removable tumors will receive different radiation doses to find the safest level. The goa…

This study tests whether silver diamine fluoride or silver fluoride, sometimes with a special LED light, can stop early cavities in the back teeth of young adults. About 366 high-risk dental students will receive one of these treatments. The goal is to see which approach works be…

This study compares two types of dental glue used to attach braces to teeth. One is a traditional three-step system, the other a simpler two-step system. The goal is to see which causes less damage (white spots) to tooth enamel. Thirty-four teenagers will have each type of glue u…

This study tests whether a new bioactive filling material helps teeth repair themselves after deep cavities are removed. 66 adults with deep decay will get either the bioactive filling or a standard one. Researchers will check for new tooth layer formation and pain over 2 years.

This study compares the natural chewing stick Miswak to standard fluoride toothpaste for managing tooth sensitivity and preventing cavities in children aged 6-12 with a condition called Molar-Incisor Hypomineralization (MIH). MIH causes weak, discolored enamel that is prone to pa…

This phase II trial tests whether surgically cutting the lingual nerve (which controls tongue sensation) can make chemoimmunotherapy work better for people with advanced tongue cancer. 69 adults with stage T3/T4 tongue cancer will receive the nerve cut along with two cycles of ti…

This study compares a new, easier-to-use tooth-colored filling material to a standard one for cavities between back teeth. Fifty adults aged 18-64 with cavities will receive one of the two fillings and be checked after 12 months for how well they hold up, look, and feel. The goal…

This study tests a new type of dental filling made with graphene, a super-strong material, for teenagers aged 10-16 who have weak enamel (a condition called MIH). The fillings are custom-made using a digital scanner and are meant to be more durable and less sensitive than standar…

This study looks at two methods for cleaning and filling infected baby molars in children aged 5-7. One method uses a manual tool, the other a rotating tool. The goal is to see which works better over a year. About 44 children will take part.

This 6-week study tests whether an AI-based toothbrush (Xiaomi T501) with pressure sensing and coaching removes more plaque and reduces gum bleeding than a standard electric or manual toothbrush. Thirty-three adults with plaque-induced gingivitis will be randomly assigned to one …

This study looks at whether applying cold (cryotherapy) during a pulpotomy—a procedure that removes infected nerve tissue from a tooth—improves the chance of saving the tooth. Researchers will compare treatment success in 140 healthy adults with deep cavities. Success means no pa…

This early-phase trial will test BCT301, a type of immune cell made from stem cells, in 10 people with severe autoimmune diseases like lupus and scleroderma. Participants receive a single infusion of these cells after a short course of chemotherapy. The main goal is to check safe…

This study compares two dental treatments for teeth with deep cavities and reversible pulpitis (early nerve inflammation). One treatment caps the exposed nerve directly, while the other removes a small part of the nerve before capping. The study will include 138 people aged 15-40…

This study tests whether two doses of stem cells, given four months apart, can improve saliva production and reduce dry mouth in people who had radiation for head and neck cancer or have Sjögren's disease. One hundred participants will receive either stem cells or a placebo. The …

This early study tests a new treatment called CD19 UCAR-T cells for people with autoimmune diseases like lupus, vasculitis, and Sjögren's syndrome. The therapy uses modified immune cells to target and calm the overactive immune system. The main goals are to check safety and see i…

This study compares three ways to handle the dental pulp (tooth nerve) after transplanting a wisdom tooth to replace a damaged molar. 360 people aged 18-40 will be randomly assigned to receive either standard root canal treatment weeks after surgery, a special root tip procedure …

This study tests whether shorter dental implants (6.3mm) work as well as standard ones (9mm) for people with low bone height in the upper jaw who need a sinus lift. Thirty-six adults will be randomly assigned to receive one of three implant types. Researchers will track complicat…

This study will test whether a liquid called silver diamine fluoride works as well as gentle fillings (atraumatic restorative treatment) for stopping cavities in children aged 2 to 5. About 156 kids from kindergartens will get one of the two treatments, and researchers will check…

This study tests whether alternating injections of a steroid (triamcinolone) and platelet-rich plasma (PRP) can improve mouth opening and reduce burning pain in people with oral submucous fibrosis, a condition that causes stiffness and can lead to cancer. Forty adults with modera…

This study compares two dental procedures for treating deep cavities in baby molars of children aged 6-8. One group gets a partial nerve treatment (pulpotomy) using a special cement, while the other gets a full root canal (pulpectomy) with a medicated paste. Researchers will trac…

This study will compare two dental filling materials—alkasite-based resin and nanohybrid composite resin—for treating cavities in the chewing surfaces of children's baby molars. About 50 children aged 4-6 will receive one of the two fillings and be checked at 3, 6, and 12 months …

This study tests a new root canal filling made from zinc oxide and ozonated olive oil against a standard material called Metapex in children aged 3-5 with cavities in their front teeth. Over 12 months, researchers will check for pain, swelling, and healing on X-rays. The goal is …

This study tests whether taking a short course of capecitabine pills before surgery can shrink tumors and improve outcomes for people with HPV-negative head and neck cancer. About 75 adults with stage III or IVa cancer will be randomly assigned to either standard care or capecita…

This study compares two surgical techniques to treat single gum recession defects, where the gum has pulled away from the tooth. One method uses a tunnel without cuts, the other adds a small cut. The goal is to see which covers the exposed root better and is less invasive. The tr…

This study compares two dental procedures for treating infected baby molars in children aged 4 to 8. One method removes only the infected part of the tooth's nerve (pulpotomy), while the other removes the entire nerve (pulpectomy). The goal is to see if the simpler pulpotomy work…

This study looks at how different 3D-printed materials affect gum health and restoration success in teeth with deep cavities that need margin elevation. Researchers will treat 48 patients and check their teeth at 6 and 12 months using dental and gum health scores. The goal is to …

This study tests whether natural substances like grape seed extract and glycyrrhizin can replace antibiotics in a procedure to revive dead permanent teeth in children aged 7-13. The goal is to restore blood flow and promote root growth while reducing pain and infection. The trial…

This study compares two cavity removal methods in 144 adults with deep cavities and reversible pulpitis (tooth nerve inflammation that can heal). One method removes all decay, the other leaves some near the nerve. Researchers will check pain, tooth vitality, and X-rays over 12 mo…

This study tests how mouth rinses made with monk fruit or Splenda affect saliva acidity and levels of cavity-causing bacteria. 90 healthy young adults (ages 20-24) with no active cavities will rinse with one of the sweetener solutions. Saliva samples will be checked before rinsin…

This study tests whether a special silver liquid (silver diamine fluoride) can stop tooth decay in elderly people living in nursing homes. Sixty participants will either get the silver treatment or a placebo, and their teeth will be checked after 6 and 12 months. The goal is to i…

This study tests whether different fluoride treatments—like varnishes, solutions, and mousse—can stop root cavities from getting worse in adults over 44. About 136 participants in Switzerland will use these products at home or get them applied by a dentist twice a year. The goal …

This study tests whether a gel made from a patient's own blood (platelet-rich fibrin) can help regenerate the inner part of infected or dead teeth in adults. 57 participants will receive either the gel or a standard blood-clot treatment. The goal is to see if the gel reduces infe…

This early study tests a special contact lens (MSCohi-O) for people with Sjögren's syndrome whose dry eyes don't improve with standard treatments. Twelve participants will wear the lenses for 12 hours a day over 14 sessions. Researchers will check for side effects and measure cha…

This study compares a new material made from eggshells (calcium hydroxyapatite) to a standard one (calcium hydroxide) for protecting the nerve in deep cavities. Fifty-four adults with reversible pulpitis will receive one of the two materials after cavity cleaning. Researchers wil…

This study tests whether a less invasive dental procedure called full pulpotomy can heal infected molars as well as root canals. Researchers will treat 128 adults with deep cavities and compare healing in teeth with and without infection at the root tip. If successful, it may off…

This study tests two ways to improve gum tissue around dental implants in adults with missing teeth. One method uses a collagen membrane from cows, the other uses a small piece of tissue from the roof of the mouth. The goal is to see which approach leads to healthier gums and bet…

This study will test three different materials—hyaluronic acid, TheraCal, and MTA—used to treat deep cavities in children's baby molars. Sixty-six kids aged 4 to 8 will receive one of the treatments, and researchers will check for pain, swelling, and X-ray changes over 12 months.…

This early-stage trial will test an oral probiotic called R-2487 in 36 adults with Sjogren's syndrome. The main goal is to see if the probiotic is safe and tolerable. Researchers will also check for changes in disease activity and inflammation using blood and stool samples. The s…

This study will test two types of dental cement—bioactive and resin—to see which one works better for putting zirconia crowns on children's front teeth. Sixty kids with cavities in at least two baby teeth will get crowns, and researchers will check how well the crowns stay on, if…

Researchers are testing a device called BlueCheck to see if it can reliably find early enamel lesions and track how they change over 12 weeks. Participants aged 13 and older with active enamel lesions but no cavities needing immediate fillings receive high-fluoride toothpaste and…

This trial is testing two new imaging tracers, called CM500, to see if they can help detect solid tumors anywhere in the body. The tracers are given by injection and then used with PET scans to create detailed images. The study includes healthy volunteers and people with various …

This study compares artificial intelligence analysis of dental photographs to standard clinical exams for detecting white spot lesions—early signs of tooth decay. Researchers will train AI models (YOLO and Mask-RCNN) on 329 labeled images from adult patients at Cairo University D…

This study will check if smartphone photos, 3D dental scans, and a special fluorescent light can accurately detect early cavities in people who have finished braces. Thirty participants aged 11 to 46 with early white spots on their teeth will be followed for three months. Researc…

This study will collect thousands of photos of mouth lesions from patients seen over 50 years at a French hospital. Experts will review each photo to confirm the diagnosis. Researchers will then use these images and patient data to train an AI system to automatically identify can…

This study looks at whether two substances in the blood of a tooth's pulp—IL-8 and presepsin—can help dentists tell the difference between a tooth infection that can heal on its own and one that needs a root canal. Researchers will collect pulp blood samples from 50 patients with…

This study will check if a simple questionnaire can accurately identify gum disease in adults. About 291 participants in Saudi Arabia will fill out the questionnaire and then have a standard dental exam. The goal is to see how well the questionnaire matches the exam results, whic…

This study will compare three methods for testing whether a tooth's nerve is alive (vital) or dead (nonvital): laser Doppler flowmetry, cold testing, and electric pulp testing. About 150 people who need root canal treatment will receive all three tests before treatment. The goal …

This study tests a handheld scanner that uses safe near-infrared light to find early cavities without radiation. Fifty adults scheduled for a tooth extraction will get an extra 5-minute scan before their procedure. The scanner's results will be compared to standard X-rays and vis…

This study will test whether artificial intelligence can help diagnose oral lesions that might turn into cancer. Researchers will use photos of the lesions and cell samples from the mouth, along with a special blue stain, to train an AI model. The goal is to see if the AI can mat…

This study will test if people can accurately measure their own tonsil size using a mirror, flashlight, and phone camera. Ninety participants will first assess their tonsils at home, then have their tonsils evaluated by a medical student and two ear, nose, and throat specialists.…

This study will enroll 2,000 adults to see if non-invasive methods like smartphone photos, dental X-rays, and questionnaires can accurately detect gum disease compared to a standard clinical exam. Researchers will use artificial intelligence to analyze the images and combine data…

Researchers in Suzhou, China, are testing whether a comprehensive oral health program in preschools and primary schools can reduce tooth decay. The program includes lessons on oral hygiene, guided toothbrushing and rinsing practice, and support from teachers and parents. About 2,…

Researchers are studying whether aloe vera mouthwash can prevent or reduce the severity of oral mucositis, a painful mouth sore that often affects people receiving chemotherapy for acute leukemia. The trial compares aloe vera mouthwash plus usual care against usual care alone in …

Children who receive hematopoietic stem cell transplants often develop painful mouth sores called oral mucositis, which can lead to poor eating, infection, and longer hospital stays. This trial tests whether a structured oral care program, including caregiver education, supervise…

This trial tests whether training nursing home staff to provide better oral hygiene can reduce pneumonia in residents aged 60 and older. Participants will use special toothpastes and mouthwashes, including stannous fluoride and chlorhexidine options. The study measures how many r…

This trial tests whether sending oral health tips via WhatsApp to mothers, in addition to standard face-to-face advice, improves their knowledge and their children's toothbrushing habits. Mothers of children aged 3 to 6 will receive either usual education alone or with 16 additio…

This trial tests whether swabbing toddlers' teeth with povidone iodine can prevent tooth decay and reduce cavity-causing mouth germs. Children aged 1 to 3 will have their teeth swabbed weekly for the first month and then monthly, with some also receiving a daily probiotic. The st…

This trial tests whether a silver nanoparticle mouthwash can reduce cavity-causing bacteria in children as effectively as chlorhexidine, but without the staining and taste issues. About 96 children aged 6–12 at high risk for cavities will rinse twice daily for 14 days. The study …

This trial tests whether cleaning the chewing surfaces of children's teeth with a fine erythritol powder spray (Guided Biofilm Therapy) before applying a protective sealant helps the sealant stay in place longer than the standard rotary-brush polishing. Each child aged 6–10 will …

This trial tests whether a fluoride-releasing adhesive used to attach braces can prevent white spot lesions—early signs of decay—on teeth. About 40 adolescents getting braces will have standard adhesive on one side of their upper jaw and the fluoride sealant on the other. After 3…

This study tests whether a simple, low-cost oral health program for pregnant women in rural Nepal can reduce the number of babies born too early, too small, or underweight. About 2,280 women will either receive daily antiseptic mouthwash and intensive oral hygiene education, or j…

This study tests whether applying povidone iodine (a disinfectant) to toddlers' teeth before fluoride varnish prevents cavities better than fluoride varnish alone. About 393 children aged 6-24 months with healthy teeth or early white spots will be followed to see which approach r…

This study tests whether light therapy (photobiomodulation) can prevent mouth sores in children receiving chemotherapy. Fifty children aged 0-30 will receive daily light treatments during hospital stays and at home. Researchers will check if the therapy is easy to use and accepta…

This pilot study tests two light therapy devices—one placed inside the mouth and one outside—to prevent and treat painful mouth sores caused by radiation therapy. Sixty adults with oral cavity or oropharynx cancer will receive light sessions twice a week for prevention, then thre…

This study tests if using a diode laser before applying a tooth-colored sealant helps it stick longer and prevent cavities better. About 111 young adults aged 17-22 will get sealants on their back teeth, with or without laser pre-treatment. Researchers will check sealant retentio…

This study tests whether a substance made from a patient's own blood, called platelet-rich fibrin (L-PRF), can prevent a serious condition called jawbone death after tooth extraction. The trial will include 40 people at high risk due to past radiation or certain medications. Half…

This study tests whether a modified herbal mouthwash can prevent painful mouth sores caused by radiation therapy in people with head and neck cancer. About 156 participants will use either the herbal mouthwash or a placebo during their radiation treatment. The goal is to see if t…

This study tests if a spray called Kangfu Spray can prevent severe mouth sores in people with oral cancer who are getting radiation therapy. About 140 participants will either get the spray plus standard mouth care, or standard care alone. The goal is to see if the spray reduces …

This study tests whether motivational interviewing — a supportive, patient-centered conversation style — can help mothers adopt better oral care habits for their infants, preventing early childhood caries. Researchers will enroll 228 mother-infant pairs in Malaysia, with half rec…

This study will test a new self-sticking dental material against a standard sealant to see which better prevents cavities in children's permanent molars. About 88 healthy kids aged 6-8 with high cavity risk will take part. The goal is to find out which material stays on teeth lon…

This study tests if a special light (photobiomodulation) can prevent and treat painful mouth sores caused by chemotherapy in children aged 4-17 with cancer. Half of the 49 participants will get light therapy, and the other half will get a standard gel. The goal is to see if the l…

This study tests an oral spray made from stem cell exosomes to prevent severe mouth sores in head and neck cancer patients undergoing radiation. 200 participants will use the spray three times daily, starting a week before radiation and continuing for two weeks after. The goal is…

This study tests two simple, low-cost methods—cold application (like ice chips) and artificial saliva—to prevent painful mouth sores caused by chemotherapy. About 60 cancer patients starting chemo will be randomly assigned to one of the two treatments or standard care. The goal i…

Researchers compare Er:YAG laser cavity preparation with conventional rotary drills in adults who have permanent premolars scheduled for extraction as part of orthodontic treatment. Each participant receives both methods on two different teeth, at separate visits, and rates pain …

Researchers compare two methods for replacing a missing front upper tooth with an implant right after extraction. One method, the Socket-Shield technique, leaves a thin piece of the tooth root in place to help protect the jawbone and gums. The other method uses the standard appro…

Researchers are testing a gel made from orange peel extract to see if it can reduce the severity of mouth sores caused by radiation therapy in people with head and neck cancer. Thirty adults receiving radiation will be split into two groups: one gets the orange peel gel, the othe…

Researchers are testing an experimental drug called ONO-4915 in adults with primary Sjogren's disease, a condition that causes dryness, fatigue, and pain. The trial enrolls about 60 people who have moderate to severe symptoms and a positive anti-SS-A/Ro antibody. Participants rec…

This study looks at whether using different root canal tools (TruNatomy vs ProTaper Gold) and different sealers (AH Plus vs TotalFill BC) can reduce pain after a root canal. About 144 adults with a tooth infection will take part. They will rate their pain at several times over a …

Researchers at the University of Iowa are studying people with thin gum tissue who need a gum graft to cover exposed tooth roots. The trial compares two ways of preparing the gum bed before placing a graft: removing all tissue down to the bone, or leaving a thin layer of tissue o…

This trial tests whether a toothpaste with calcium sodium phosphosilicate reduces tooth sensitivity better than a regular fluoride toothpaste. About 192 adults with sensitive teeth will brush twice daily for 8 weeks. Researchers measure how teeth respond to a puff of air and a ge…

This study tested whether a technique called apical patency—gently passing a small file just beyond the tooth root during root canal treatment—reduces pain afterward. 150 adults with inflamed but painless teeth (asymptomatic irreversible pulpitis) were randomly assigned to receiv…

This trial tests whether giving IV fluids on a fixed schedule during chemoradiation for head and neck cancer can reduce severe side effects like mouth sores, swallowing problems, and kidney injury. Half of the participants will receive IV fluids twice a week starting in week 3 of…

This study compares two ways of applying cold inside a tooth during a root canal to see which reduces pain better. Ninety adults with a painful, inflamed tooth nerve will be randomly assigned to receive either ice sticks, a cold spray, or no extra cold treatment. Patients will ra…

This trial investigates whether a single injection of dexamethasone, a steroid, given before a root canal can lower pain during the procedure. It includes adults with severe tooth pain from symptomatic irreversible pulpitis. Participants receive either dexamethasone or a placebo,…

This trial asks whether a newer 'bulk-fill' composite filling causes less tooth sensitivity after cavity repair than the traditional layer-by-layer method. Dentists often apply standard fillings in thin layers to avoid shrinkage gaps, but bulk-fill materials can be placed in thic…

This trial tests whether low-level laser therapy or a hyaluronic acid gel can improve healing after free gingival graft surgery, a procedure to treat receding gums. Adults with insufficient gum tissue in the lower front teeth will receive surgery alone, surgery plus laser, or sur…

This study compares two ways of numbing a child's tooth for a root canal on a baby molar: a computer-controlled system that delivers anesthetic slowly and steadily, versus a traditional injection. The goal is to see which method causes less anxiety and pain in children aged 6 to …

This trial tests whether taking a single dose of diclofenac potassium before dental treatment can improve the numbing effect of local anesthesia and reduce pain after the procedure. Adults with severe tooth pain from irreversible pulpitis in lower molars will receive either 50mg,…

This trial compares two simple treatments—sucking on ice chips or using a lidocaine spray—to see which better prevents or reduces painful mouth sores caused by chemotherapy. About 60 adults with cancer who are about to receive chemotherapy will be randomly assigned to one of the …

This trial tests whether a two-week tongue-strengthening exercise, done with a non-invasive device, can improve speech fluency in people with tongue-tie or slurred speech. The exercise relies on muscle resistance training, not medication or electronics. Researchers will measure c…

This trial compares two different file systems used during root canal treatment for infected lower molars. The goal is to see whether a newer, minimally invasive single-file system leads to less pain after the procedure than the standard Wave One Gold system. Adults with a specif…

This study tests whether a mobile-based rehabilitation program, built on the PERMA-H model of well-being, can improve hope, self-confidence, and social support in people recovering from a tracheostomy due to oral cancer. Participants use a WeChat mini-program with a chatbot and t…

This study tests whether a 3% hypertonic saline (saltwater) rinse, used at the end of a root canal procedure, can reduce pain and inflammation better than the standard 0.9% saline rinse. Forty adults with painful tooth inflammation will receive one of the two rinses, and their pa…

This study compares two ways to lift the soft palate during throat surgery to see which causes fewer injuries. About 138 people aged 2 to 70 who need this type of surgery will be randomly assigned to either the standard double-strap method or a new full-wrap method. The goal is t…

This study tests whether a traditional Chinese herbal drink called Sancai Fengsui Decoction can help heal painful mouth sores caused by radiation therapy for head and neck cancer. About 126 adults who have developed moderate to severe mouth sores after radiation will receive eith…

This study tests whether using very cold water (around 2-3°C) to rinse the inside of a tooth during a root canal can lower pain afterward. The trial includes adults aged 20-40 with painful, infected lower molars. Participants are randomly assigned to receive either cold rinses th…

This trial compares early versus delayed acupuncture to reduce dry mouth caused by chemoradiation in head and neck cancer patients. Participants receive acupuncture either during chemoradiation or after, and their dry mouth symptoms are tracked for a year. The goal is to find the…

This study looks at whether using a cold saline rinse after ultrasonic cleaning during a root canal can lower pain afterward. Adults with an inflamed tooth nerve will get either ultrasonic cleaning alone or followed by a cold saline flush. Pain levels are tracked for three days a…

This study tests two simple treatments for tooth sensitivity caused by worn enamel: a blue diode laser and a bioactive glass powder. Thirty adults with two similarly sensitive teeth will each receive both treatments (one per tooth) to see which works better. The goal is to find a…

This study tests whether sucking on ice chips during chemotherapy can prevent or reduce the severity of painful mouth sores (oral mucositis) in cancer patients. 102 adults receiving 5-fluorouracil or methotrexate will be randomly assigned to either get ice chips during infusion p…

This pilot study will test whether a dental gel called theranovis can improve gum health in people with gingivitis (mild gum disease). Twenty adults with gingivitis will use either the gel or a placebo twice daily for a period. Researchers will measure changes in gum bleeding and…

This study tests whether three different desensitizing toothpastes can reduce tooth sensitivity in people with braces. About 200 adults aged 18-40 with mild to moderate sensitivity will use one of the toothpastes or a placebo for 8 weeks. The goal is to see if the special toothpa…

This study compares two strengths of sodium hypochlorite (a disinfectant used during root canals) to see which causes less pain afterward. 116 adults needing a root canal will be randomly assigned to receive either a 2.5% or 5.25% solution. Pain levels will be measured at 6, 12, …

This study will test a 16% carbamide peroxide gel used at home in custom trays for 90 minutes daily over six weeks. Ten adults with healthy gums and no prior whitening will have their tooth color measured by a special device and report how their quality of life changes. The goal …

This study compares two ways to remove cavities in children's baby molars: a special gel that softens decay, versus scraping by hand. The goal is to see which method causes less pain and is more acceptable to kids. Twenty-eight healthy children aged 5 to 9 will take part, and the…

This study tests whether a gel made from the Libidibia ferrea plant can reduce tooth sensitivity after professional whitening. Seventy-five adults will receive either the experimental gel, a standard desensitizing gel, or a placebo before bleaching with hydrogen peroxide. Partici…

This study tests a painless light treatment called photobiomodulation for children aged 3 to 14 who get severe mouth sores from chemotherapy. The treatment uses a handheld red light device for about 5-10 minutes daily for four days, alongside standard care. Researchers want to se…

This study tests whether a new type of root canal filling material (bioceramic nano-coated gutta-percha with a bioceramic sealer) causes less pain and swelling after treatment compared to the standard material (gutta-percha with a resin sealer). About 30 adults aged 20-55 with a …

This study will compare two types of tooth separators—elastomeric and nickel-titanium—used before placing orthodontic bands for braces. Thirty patients with crowded teeth will have one separator type on each side of their mouth. Researchers will measure how well they create space…

This study will compare two types of root canal sealers, NeoSealer Flo and CeraSeal, in 30 adults needing root canal treatment for painful tooth inflammation. The goal is to see which sealer causes less pain after the procedure and less leakage of material beyond the tooth tip. P…

This phase 2 trial tests whether taking taurine (a common amino acid) can prevent or reduce severe mouth sores caused by radiation therapy in people with nasopharyngeal cancer. 130 patients will take taurine pills or receive standard care starting 3 days before radiation until 1 …

This study tests four different ways to clean infected root canals to see which one reduces bacteria and pain the most. Forty adults with tooth infections will be randomly assigned to one of the cleaning methods. The goal is to find a better way to disinfect teeth while making th…

This study tests whether a gel made from propolis (a bee product) can reduce tooth sensitivity after professional whitening. 66 adults will receive either propolis gel, a standard desensitizer, or a placebo before bleaching. Their pain and color change will be tracked for two wee…

This study compares two self-ligating bracket systems (Damon Ultima and Pitts 21 Pro) in 40 people with mild-to-moderate crowding. Researchers will measure treatment time, pain, root resorption, and alignment quality to see if one system works better. The goal is to find which br…

This study tests a gel called Cariclast that softens tooth decay, allowing dentists to remove cavities without a drill. It will involve 24 children aged 4-7 with cavities in their back baby teeth. The goal is to see if this method causes less pain and is more accepted by kids tha…

This study tests whether applying a dipotassium oxalate gel before placing a filling can reduce tooth sensitivity afterward. 64 adults with sensitive tooth cavities will be randomly assigned to get the gel or standard treatment. Pain is measured at 24 hours, 7 days, and 30 days u…

This study compares two ways of using an anti-inflammatory drug (ketorolac) during root canal treatment: one at room temperature and one chilled. The goal is to see if the cold version reduces pain better after the procedure. Sixty adults with tooth infections will be enrolled, a…

This study compares different numbing methods to reduce pain during dental cavity treatment. About 204 adults with tooth decay will receive either a light-based device, a numbing gel, or a placebo before local anesthesia. Researchers will measure pain during and after the procedu…

This study tests whether special scaffolds placed inside a tooth after removing the infected pulp can lower pain and improve healing. About 36 adults with a painful, infected lower molar will be treated and followed for up to a year. The goal is to find a better way to save the t…

This study compares a 1% melatonin gel to a standard calcium hydroxide paste placed inside the tooth after root canal cleaning. It aims to see which one better reduces pain, lowers bacteria, and affects a certain protein linked to healing. The trial will involve 50 adults with a …

This study compares two ways of doing a pulpotomy (a type of root canal) for adults with a painful, infected tooth. Half the treatments will use a special dental microscope, and half will not. The goal is to see if the microscope helps the tooth heal better over time. Fifty healt…

This study tests whether daily red light therapy can prevent or reduce skin and mouth side effects in children aged 0-16 receiving radiation for cancer. About 248 kids will get a daily LED light treatment on the radiated area. Researchers will compare their side effects to those …

This study compares two treatments for dentin hypersensitivity (tooth sensitivity). One group gets a special varnish (CPP-ACPF) alone, the other gets the varnish plus a low-level laser treatment. 70 adults with sensitive teeth will rate their pain before and after. The goal is to…

This study tests a new rinse called Triton during root canal treatment for dead teeth. It aims to see if it kills more bacteria and causes less pain afterward than the standard rinse. Thirty-six adults with infected lower molars will take part. The results could help dentists cho…

This study tests whether using a special rotary file (a spinning tool) causes less pain after a baby tooth root canal than the traditional manual file. Fifty children aged 4 to 6 with an infected baby molar will be randomly assigned to one of the two methods. Parents will rate th…

This study tests whether a new way of aiming radiation beams (non-coplanar) can reduce side effects like dry mouth and swallowing problems in people with head and neck cancer. About 70 adults with cancer of the mouth or throat will be randomly assigned to standard or new radiatio…

This study looks at whether using a special rotating tool (rotary file) instead of a hand tool (manual file) during a baby molar root canal (pulpectomy) makes children behave better. It will include 54 children aged 4-6 who need this treatment. The main goal is to see if the rota…

This study tests whether applying cold (cryotherapy) to the gums right after a numbing shot can make root canal treatment less painful. About 100 adults with an infected lower premolar tooth will be randomly assigned to receive standard numbing methods with or without the cold tr…

This study compares a homemade herbal mouthwash to chlorhexidine, the standard mouthwash for gingivitis. Gingivitis is a common gum disease caused by plaque buildup. The herbal option may have fewer side effects. The trial will include 12 adults with plaque-induced gingivitis and…

This study compares two different medicines placed inside a tooth during a root canal to see which one is better at killing bacteria and reducing pain afterward. About 52 adults with infected single-root teeth will take part. The goal is to find which treatment leads to less disc…

This study tests whether using a dental operating microscope during a pulpotomy (a partial root canal) reduces pain and improves quality of life afterward. 82 adults with deep cavities and tooth nerve pain will be randomly assigned to get the procedure with or without the microsc…

This study tests whether a mobile education app based on Kolcaba's Comfort Theory can improve comfort and well-being for people living with a stoma. About 68 adults scheduled for stoma surgery will be randomly assigned to use the app plus standard care, or standard care alone. Th…

This study tests whether wearing a custom mouth splint (Essix appliance) can reduce pain and dry mouth in people with Burning Mouth Syndrome. Twelve adults who have already felt relief from the splint will take part. Researchers will measure pain levels, saliva volume, and protei…

This study tests a new gel that dissolves tooth decay without drilling, aiming to reduce patient anxiety. Eighty adults with cavities in lower molars will be randomly assigned to either the gel or a standard drill. The main goal is to see which method causes less pain and discomf…

This study tests whether a mouthwash containing sodium hyaluronate and Sh-Oligopeptide-85 can reduce pain and sores in people with oral lichen planus, a chronic inflammatory condition. Forty adults with painful mouth lesions will use either the test mouthwash or a standard cortic…

This study aims to find out which of two root canal sealers causes less pain after treatment. Sixty adults with tooth nerve inflammation will have root canals and then rate their pain over two days. The goal is to improve patient comfort and recovery.

This study tests whether rinsing with hydrogen water can reduce mouth inflammation and pain in people recovering from oral cancer surgery that used a free flap reconstruction. Thirty-six participants will use hydrogen water or plain water for oral care over 7 days. Researchers wi…

This study compares two ways to clean a tooth's root canal (step-back vs step-down) to see which one leads to less pain afterward. About 110 adults with a dead nerve in a single-root tooth will be randomly assigned to one method. Pain levels will be tracked for a week using a sim…

This study compares two methods for fixing cavities in children's back teeth: the Hall Technique (a less invasive approach) and traditional stainless-steel crowns. Researchers will measure bite force, jaw changes, and child comfort in 22 kids aged 6-9. The goal is to see if the g…

This study compares two single-dose pain relievers—piroxicam and prednisolone—given before a root canal to see which one reduces pain better afterward. Sixty adults with an inflamed tooth nerve and infection will take one of the drugs right before treatment. The goal is to find a…

This study compares a single-shade flowable composite resin to a multi-shade composite for filling cavities in back teeth. Thirty adults with at least four cavities will receive both types of fillings and be followed for five years. Researchers will check how well the fillings ma…

This study will test whether rinsing with cold water (15-20°C) reduces mouth soreness and improves comfort compared to room-temperature water in 200 head and neck cancer patients undergoing radiotherapy. Participants will rinse four times daily for six weeks. The goal is to see i…

This study will test if a technique called 'apical patency'—gently passing a small file just past the root tip during cleaning—can reduce pain after a root canal. 48 adults with a dead nerve and infection in a back molar will be randomly assigned to receive either this technique …

This study will compare two treatments—low-level laser therapy and hyaluronic acid gel—to see which helps children's gums heal better after removing a badly decayed first permanent molar. Thirty-six children aged 6 to 10 will receive one of the treatments right after extraction. …

This study looks at two ways of cleaning a tooth's root canal to see which one causes less pain afterward. It involves 72 adults with a specific type of tooth nerve pain in their front teeth. Participants will have their root canals cleaned using one of two methods, then rate the…

This early trial tests whether exosome eye drops can safely relieve dry eye symptoms in people with Sjögren's syndrome. Twelve adults whose dry eyes haven't improved with standard treatments will use the drops four times daily for two weeks. The main goal is to check for side eff…

This study tests whether applying Gluma desensitizer before a filling can reduce tooth sensitivity afterward. Sixty adults with cavities in their back teeth will be randomly assigned to get either the desensitizer plus a standard filling or just the standard filling. Their pain r…

This study compares a computer-controlled injection device (Starpen) to a standard syringe for numbing and extracting upper baby molars in 38 children aged 6-8. The goal is to see if the new device causes less pain during the injection. Children will rate their pain using a faces…

Researchers want to understand the different ways pain works in people with rheumatic diseases such as lupus, rheumatoid arthritis, and Sjogren's syndrome. The study enrolls up to 225 people aged 9 to 85 who have or may have a rheumatic disease, plus healthy volunteers matched by…

Researchers at Kırıkkale University are studying how GLP-1 receptor agonists, drugs prescribed for type 2 diabetes and obesity, affect saliva and oral health. Fifty adults aged 18 to 65 who are newly prescribed these drugs provide saliva samples and undergo dental exams at the st…

Researchers at Assiut University are studying whether long-standing untreated enlarged adenoids are linked to nasal septum deviation in adolescents aged 10 to 18. The adenoids are immune tissues at the back of the nose that can stay enlarged and block airflow. The study will comp…

Researchers at Assiut University are studying whether rheumatic diseases such as rheumatoid arthritis, lupus, and Sjogren's syndrome harm the meibomian glands, the tiny eyelid glands that keep tears from evaporating. The study compares 120 people with these conditions to 30 healt…

This study aims to understand why some teeth fail to erupt (come in) properly. Researchers will look at dental records and test for changes in the PTH1R gene in 50 patients with eruption problems. The goal is to improve diagnosis and distinguish between different causes, such as …

This study looks at how gum inflammation and the bacteria in your mouth interact with your body's immune system. Twenty healthy adults will use a special toothpaste and then stop brushing for a period to see how inflammation and bacteria change. The goal is to better understand t…

This study investigates whether a protein called FCRL5, found on certain immune cells, can serve as a marker for multiple sclerosis (MS) activity and treatment response. Researchers will track MS patients with blood tests every six months for two years, and compare their results …

This study asks whether 3D-printed custom trays can create dental molds as accurately as traditional custom trays. Thirty adults with no upper teeth will have molds made using both methods, and the resulting casts will be compared using 3D scanning technology. The goal is to see …

This study looks at whether smoking changes the tissue in the roof of the mouth where a gum graft is taken, and whether that affects how well the graft covers exposed tooth roots. It will compare 12 smokers with 12 non-smokers, all receiving the same surgical procedure for gum re…

This study looks at how the mouth heals after gum surgery in people with and without diabetes. Researchers will measure wound size and track healing over 12 weeks. They will also check bacteria and inflammation levels to see what affects recovery. The goal is to learn why healing…

This study looks at how well the mouth heals after gum surgery in people with diabetes compared to those without. Researchers will track healing, measure gum recession, and check factors like bacteria and inflammation. The goal is to understand what affects recovery in diabetic p…

This study looks at whether changes in regulatory T cells (a type of immune cell) after facial reconstruction surgery can predict how quickly patients heal and how long they stay in the hospital. Researchers will collect blood samples from about 60 adults before, during, and afte…

This study looks at whether music therapy can reduce painful mouth sores (oral mucositis) in children with cancer. Researchers will interview 50 families online to learn about their experiences with music therapy. The goal is to find patterns that could lead to better, drug-free …

This study follows about 146 mother-infant pairs to see if tongue-tie (ankyloglossia) affects how well breastfeeding goes. Newborns are checked for tongue-tie within their first 72 hours using the TABBY tool, and breastfeeding effectiveness is measured with the LATCH scale. The r…

This study aims to find biological markers in saliva, mouth rinse, blood, or tissue that could help identify and predict the course of oral cancer, gum disease, and tooth decay. Researchers will collect health information and samples from 4,000 adults with these conditions and he…

This study looks back at the medical records of 60 adults with head and neck cancer who received radiation therapy, with or without chemotherapy, and used a topical mouth rinse made from olive oil, betaine, and xylitol. The goal is to see how often severe mouth sores (oral mucosi…

This study uses a novel ingestible mini-pill to collect bacteria samples from different parts of the gut in people with Sjögren's disease and healthy volunteers. By comparing these samples with mouth and stool bacteria, researchers hope to understand how the microbiome relates to…

This study looks at how common cavities are in the first permanent molars of 6- to 7-year-old Egyptian children and whether diet and tooth-brushing habits play a role. Researchers will examine 272 children's teeth and ask parents about their child's eating and oral hygiene routin…

This study looks at whether GLP-1 receptor agonists like semaglutide and tirzepatide, used for weight loss, change saliva composition and increase tooth wear. Researchers will measure saliva calcium, pH, flow rate, and dental erosion in 40 adults before and 3 months after startin…

This study looks at saliva from people with osteoporosis to measure certain immune markers and an enzyme called MMP-8. Researchers also check participants' dental cavities. The goal is to better understand how osteoporosis might affect oral health. No treatments are given—only sa…

This study looks at whether a gel made from polynucleotides and hyaluronic acid can help gum tissue heal better after a graft is taken from the roof of the mouth. Fifteen adults with gum recession will have grafts taken from both sides of their palate in two separate surgeries, n…

This study looks at whether children with molar-incisor hypomineralization (MIH) — a condition that weakens tooth enamel — have different levels of gum inflammation markers compared to children without MIH. Researchers will measure inflammatory substances in gum fluid from 76 chi…

This study investigates whether substances in saliva, specifically interleukin-6 levels and certain gene variations, can indicate whether oral cancer has spread to lymph nodes in the neck. Researchers will collect saliva samples from adults with oral squamous cell carcinoma befor…

This study will measure how well people with gum disease can chew. One hundred adults with periodontitis will chew a special gum for 20 cycles to test their chewing performance. Researchers will also check the severity of their gum disease to see if there is a link. This is an ob…

This study looks at how a standard laryngoscope blade (Macintosh) works during breathing tube placement in 100 adults with normal mouth opening. The goal is to gather measurements that may later help doctors manage patients with restricted mouth opening from submucous fibrosis. R…

This study looks at how well 3D-printed resin fillings hold up in back teeth with large cavities. Researchers will compare two different ways of shaping the tooth before placing the filling. Fifty adults will be followed for 18 months to see which design leads to fewer cracks or …

This study will take 3D scans of the inside of the mouth from 240 people with rare bone or cartilage diseases and from healthy volunteers. Researchers will use shape analysis and artificial intelligence to see if these scans can help tell different diseases apart. The goal is to …

This study aims to create a patient decision aid for young people aged 11-18 who are missing one or both upper front teeth, a condition affecting 1 in 50 people. Researchers will interview patients and their parents, and hold focus groups with clinicians, to understand what matte…

This study tests how well three different toothpastes repair early tooth damage (enamel lesions) in 30 healthy adults aged 18-70. Participants wear a removable mouth device with human enamel pieces for 14 days per toothpaste, with breaks in between. Researchers measure mineral ga…

This study follows 70 adults aged 20-60 who need root canal treatment on a premolar or molar. Researchers measure how hard they can bite and how force spreads across teeth before treatment, after root canal, after a crown, and up to 4 years later. They also ask about chewing comf…

This study will collect data from 10,000 people undergoing upper endoscopy to build an AI model that predicts the risk of developing stomach or esophageal cancer. Researchers will combine information from endoscopy images, tissue samples, genetics, and gut bacteria. Participants …

This study looks at whether people with oral lichen planus (a chronic mouth condition) have more gum disease than those without it. Researchers will compare 88 patients with oral lichen planus to 88 healthy people, all getting standard dental exams. The goal is to understand shar…

This study looks at whether getting complete dentures for the first time changes how anxious patients feel about dental visits. Researchers will measure anxiety in 70 adults who have lost all their teeth at two points: when they first get impressions made and when they receive th…

This study looks at how a disrupted body clock (like in night-shift workers) affects gum inflammation. Researchers will measure clock proteins and immune markers in the gum fluid of 116 people with and without gum disease. The goal is to understand the link between sleep-wake cyc…

This study aims to understand the different cell types in oral cancer and pre-cancerous mouth lesions. Researchers will analyze tissue and blood samples from 150 participants to map gene activity and cell interactions. They will also test whether a simple brush sample can replace…

This study asks 200 practicing midwives in Germany about their role in oral health for pregnant women and young children. Through an anonymous online survey, researchers will learn how confident midwives feel giving dental advice, what barriers they face, and what training they n…

This study follows 400 obese adults in Norway to see how weight loss from lifestyle changes, medication, or surgery affects their oral health. Researchers will measure gum disease, cavities, and tooth erosion before and after weight loss. The goal is to understand the link betwee…

This study looks at how stainless steel crowns placed on weak permanent molars (due to a condition called MIH) affect a child's bite and jaw function. Forty-six children will have their teeth scanned before, right after, and up to 3 months after crown placement. The goal is to un…

This observational study will collect pulp tissue from 1,200 adults during routine dental procedures like root canals or extractions. Researchers will analyze the tissue to understand the immune and inflammatory response at the molecular level. The goal is to see if current diagn…

This study compares a new digital denture-making technique (Easdent) with the traditional method for people who need full dentures. Twenty adults will receive both types of dentures, and researchers will measure chair time, number of visits, and patient satisfaction. The goal is …

This study tests a wireless patch that sticks to the face to monitor facial nerves during surgery, aiming to prevent nerve damage. It will be used alongside standard needle-based monitoring in 20 adults having parotid or facial surgery. Researchers will compare how well the patch…

This study will test five different types of tooth-colored fillings (bulk-fill composites) in 70 adults who need a cavity filled. The fillings use different technologies, like heating or sound waves, to see which one works best. Dentists will check the fillings right after placem…

This study tests whether injecting two dyes around the tumor and into cancerous lymph nodes can help surgeons spot hidden cancer spread in head and neck cancer. Twenty adults with oral cavity or head and neck skin cancer will receive the dyes before surgery. The goal is to see if…

This study looks at the teeth, mouth, and face health of 25 people with Mowat-Wilson syndrome, a rare genetic condition. Researchers will check for cavities, gum disease, and facial features, and ask about quality of life. No treatment is given—the goal is to gather information t…

This study tests a new approach called 'Flipped Discharge' for people with colorectal cancer who have a stoma after surgery. Instead of focusing care in the hospital, it shifts support to the home, with a nurse visit or video follow-up three days after discharge. The goal is to s…

This observational study will follow 3000 adults having oral surgery to see how often complications like infections or nerve damage occur. Researchers will collect patient and surgery details, plus surgeon predictions, to build an AI tool that might one day help prevent these pro…

This study looks at inflammation inside the tooth's inner tissue (dental pulp) in people with painful pulpitis compared to healthy individuals. Researchers will measure specific inflammation markers in saliva, gum fluid, and pulp tissue to see if they reflect the level of inflamm…

This study follows up with 220 people who previously took part in the Sjögren's International Clinical Collaborative Alliance (SICCA) study at the University of Pennsylvania. Researchers will collect tears, saliva, blood, and other samples, along with eye and mouth exams, to trac…

This observational study looks at whether eating lots of ultra-processed foods (like chips, soda, and packaged snacks) is linked to cavities and gum disease. Researchers will track the diets and oral health of 200 adults aged 18 to 65. No treatments or changes are given—just care…

This study will test several over-the-counter mouthwashes to see how they affect the balance of bacteria in the mouth and whether they influence heart health. Researchers will recruit 200 adults with or without gum disease from dental clinics and a university campus. The goal is …

This study will follow 75 adults who need root canal treatment or retreatment at a hospital dental clinic in Rome. Researchers will check how well the teeth heal using X-rays and symptom reports over up to 5 years. The goal is to understand success rates and how factors like over…

This study looks at how two types of dental cement used to attach stainless steel crowns affect gum health in 45 children aged 6-10. Researchers measured gum inflammation and certain immune markers before and one week after placing the crowns. The goal is to see if one cement cau…

This study looks at whether measuring a specific antibody, anti-Ro52, in the blood of people with Sjögren's syndrome can help predict who will develop serious problems like lymphoma or organ damage. Researchers will follow 150 patients over time to see if higher antibody levels a…

This study looks at 1,200 preschool children to understand why some get severe tooth decay. Instead of just looking at teeth, researchers will also study family stress, parenting burnout, children's sleep, and diet. The goal is to create a tool that predicts which kids are most a…

This study looks at how well a special type of dental filling called Giomer works in people with and without diabetes. Researchers will place fillings in cavities on the tooth neck and check them over 18 months to see if they stay in place and prevent new decay. The goal is to un…

This study looks at how removing the adenoids and tonsils changes children's voices and speech. Thirty-six children aged 4 to 13 will have their voices tested before surgery and again 1 and 3 months after. The goal is to help doctors better explain possible voice changes to famil…

This study looks at whether a deep cleaning of the gums can improve symptoms in people with oral lichen planus, a chronic inflammatory condition affecting the mouth. Thirty participants will receive the cleaning and be monitored for changes in signs, symptoms, and immune cell lev…

This study looks at whether sending short dental health videos through WhatsApp can improve how much 10-12 year old children in Cairo know about taking care of their teeth, and whether it changes their brushing and eating habits. About 150 children will take part, with one group …

This study looks at whether people with oral lichen planus, a chronic mouth condition, have higher risks for heart problems or blood clots. Researchers will check blood samples from 55 adults for natural anticoagulant deficiencies and antiphospholipid antibodies. The goal is to b…

This study looks at whether playing an escape room game helps nursing students learn more about stoma care and feel more confident. About 60 students will be split into two groups: one will get a lecture plus the escape room game, and the other will get only a traditional lecture…

This study will test three ways to clean clear aligners: brushing with fluoride toothpaste, using chlorhexidine mouthwash, or using an oxygen-based cleanser. Twenty-one adults will try each method for one month to see how it affects bacteria and gum health. The goal is to find wh…

This study looks at people with Enamel Renal Syndrome, a rare genetic condition that causes calcium deposits in the body, leading to kidney and blood vessel problems. Researchers will measure kidney function and test how the body handles calcium, phosphate, water, and acid. The g…

This study aims to better predict how head and neck cancer responds to chemoradiotherapy. Researchers will use MRI, PET/CT scans, and blood/tumor DNA tests from 152 patients to build a combined prediction model. The goal is to identify which patients have a complete response with…

This study looks at certain proteins (aquaporins and IL-8) in the fluid and tissue of healthy teeth and teeth with a painful, inflamed nerve (irreversible pulpitis). Researchers will collect samples from 70 adults during routine root canal treatment to compare protein levels. The…

This study aims to find genetic links between certain dental issues (like missing or extra teeth) and eye or skin conditions. Researchers will collect DNA from 5 orthodontic patients with these dental problems and a family history of eye or skin issues. They hope to identify shar…

This study uses CT scans to see how a deviated nasal septum (a crooked wall inside the nose) affects the size of the maxillary sinuses and the chance of developing sinusitis. Researchers will compare the deviated side to the normal side in 120 adults. The goal is to better unders…

This study will compare two anesthesia drugs—remimazolam and propofol—in 558 children aged 3 to 6 who are having their tonsils or adenoids removed. The main goal is to see which drug leads to better brain development 1 to 3 years after surgery. Children will be randomly assigned …

This study looks at 58 children with deep cavities in their baby molars. Dentists will perform a pulpotomy (removing the infected nerve and sealing the tooth) and measure levels of cytokines—substances that signal inflammation—in the pulp. The goal is to see if these levels can p…

This study aims to understand how certain immune proteins, called NOD1 and NOD2, relate to gum disease. Researchers will collect saliva and blood samples from 75 people with healthy gums, gingivitis, or periodontitis. They will measure levels of these proteins and other markers t…