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Ice chips vs. mouth sores: simple trick may ease chemo side effect

NCT ID NCT07327476

Symptom relief Sponsor: University of Health Sciences Lahore Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether sucking on ice chips during chemotherapy can prevent or reduce the severity of painful mouth sores (oral mucositis) in cancer patients. 102 adults receiving 5-fluorouracil or methotrexate will be randomly assigned to either get ice chips during infusion plus standard mouth care, or standard mouth care alone. The severity of mouth sores will be measured before and after treatment using a standard grading scale.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
oral ice chips (oral cryotherapy)
What this could lead to
If it works, this simple, low-cost method could help prevent painful mouth sores during chemotherapy, improving comfort and quality of life.
What could go wrong
This is a small, early-stage trial (102 people) that hasn't started yet. The benefit may be modest or not better than standard mouth care, and results may not apply to all chemo types.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 102 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jul 2026

An estimate. Start dates often move.

Expected to finish

Nov 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria * Adults aged 18-60 years. * Patients treated with 5-Fluorouracil and Methotrexate regimens. * Patients scheduled for a two-week cycle of chemotherapy. * Patients able to tolerate ice and able to communicate effectively. Exclusion Criteria * Patients with diabetes mellitus, cardiovascular disorders, or any immune- compromised disease. * Patients with head and neck surgeries, oral or pharyngeal cancer, or any problems in the oral cavity. * Patients currently enrolled in or who have signed consent for any other clinical studies that could interfere with the desired outcomes.

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Conditions

The condition(s) this trial relates to.

neoplasm stomatitis chemotherapy-induced oral mucositis prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chemotherapy induced oral mucositis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The study's own enquiry address

    This study publishes an address for enquiries. See it below .

  2. The places running it

    1 site. The list below names each one and where it is.

  3. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  4. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University of Health Sciences

    Lahore, Punjab Province, 54000, Pakistan

    Contact Email: •••••@•••••

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