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Ice chips vs. mouth sores: simple trick may ease chemo side effect

NCT ID NCT07327476

Not yet recruiting Symptom relief Sponsor: University of Health Sciences Lahore Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether sucking on ice chips during chemotherapy can prevent or reduce the severity of painful mouth sores (oral mucositis) in cancer patients. 102 adults receiving 5-fluorouracil or methotrexate will be randomly assigned to either get ice chips during infusion plus standard mouth care, or standard mouth care alone. The severity of mouth sores will be measured before and after treatment using a standard grading scale.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
oral ice chips (oral cryotherapy)
What this could lead to
If it works, this simple, low-cost method could help prevent painful mouth sores during chemotherapy, improving comfort and quality of life.
What could go wrong
This is a small, early-stage trial (102 people) that hasn't started yet. The benefit may be modest or not better than standard mouth care, and results may not apply to all chemo types.

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Conditions

The condition(s) this trial relates to.

neoplasm stomatitis chemotherapy-induced oral mucositis prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHEMOTHERAPY INDUCED ORAL MUCOSITIS

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-••••

Locations

  • University of Health Sciences

    Lahore, Punjab Province, 54000, Pakistan

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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