AI could help dentists detect oral cancer earlier without a biopsy

NCT ID NCT07318922

Not yet recruiting Diagnosis Sponsor: Ain Shams University Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study will test whether artificial intelligence can help diagnose oral lesions that might turn into cancer. Researchers will use photos of the lesions and cell samples from the mouth, along with a special blue stain, to train an AI model. The goal is to see if the AI can match or beat a specialist's ability to identify risky lesions, potentially offering a non-invasive way to catch oral cancer earlier. The study plans to enroll 120 people with conditions like oral lichen planus or leukoplakia.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Toluidine blue stain and exfoliative cytology
What this could lead to: If successful, this could lead to a non-invasive, AI-powered tool that helps dentists catch early signs of oral cancer more accurately and quickly.
What could go wrong: This is a small, early-stage study (120 people) that hasn't started yet. The AI model may not perform as well in real-world settings or on diverse populations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

lichen planus, oral oral mucosa leukoplakia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ERYTHROLEUKOPLAKIA OF MOUTH ORAL LEUKOPLAKIA ORAL LICHEN PLANUS TRAUMATIC ULCER OF ORAL MUCOSA

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