New combo therapy aims to unlock stiff jaws in oral disease
NCT ID NCT07277998
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether alternating injections of a steroid (triamcinolone) and platelet-rich plasma (PRP) can improve mouth opening and reduce burning pain in people with oral submucous fibrosis, a condition that causes stiffness and can lead to cancer. Forty adults with moderate to severe disease will receive either the alternating therapy or steroid alone over 12 weeks. The goal is to see if combining anti-inflammatory and regenerative treatments works better than the standard approach.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Triamcinolone acetonide and platelet-rich plasma (PRP) injections
- What this could lead to
- If it works, this could offer a better way to improve mouth opening and reduce pain for people with oral submucous fibrosis, potentially slowing disease progression.
- What could go wrong
- This is a small, early-stage trial with only 40 participants, so results may not apply to everyone. The alternating treatment may not work better than the standard steroid alone.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Abbasi Shaheed Hospital
Karachi, Sindh, 71510, Pakistan
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Other studies related to the condition(s) this trial covers.