Could a simple mouthwash soothe chronic mouth pain?

NCT ID NCT07280442

Not yet recruiting Symptom relief Sponsor: Universidad Complutense de Madrid Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a mouthwash containing sodium hyaluronate and Sh-Oligopeptide-85 can reduce pain and sores in people with oral lichen planus, a chronic inflammatory condition. Forty adults with painful mouth lesions will use either the test mouthwash or a standard corticosteroid mouthwash for four weeks. Researchers will measure changes in pain and lesion severity to see if the new option works as well as steroids.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: sodium hyaluronate 0.01% and Sh-Oligopeptide-85 SP mouthwash
What this could lead to: If it works, this mouthwash could offer a gentler option to reduce pain and sores from oral lichen planus without using steroids.
What could go wrong: This is a small, early-phase trial with only 40 people, so results may not apply to everyone. The mouthwash may not improve symptoms, and individual responses vary.

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Conditions

The condition(s) this trial relates to.

lichen planus, oral

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ORAL LICHEN PLANUS

Contacts and locations

Locations

Departamento de Especialidades Clínicas Odonotlógicas, Facultad de Odontología, Universidad Complutense de Madrid

Madrid, 28040, Spain

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