Old drug, new hope: thalidomide tested for Kids' fever disorder
NCT ID NCT07476625
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether thalidomide can reduce or stop fever episodes in children with PFAPA syndrome, a condition causing repeated fevers and sore throats. About 106 children aged 3 to 18 will take either thalidomide or colchicine daily for 6 months. Researchers will track how many children have no fevers during treatment and monitor for side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- thalidomide
- What this could lead to
- If it works, this could offer a new treatment option to control fever episodes in children with PFAPA syndrome.
- What could go wrong
- This is an early-stage trial with only 106 participants, so results may not apply to all children. Thalidomide has known side effects, including drowsiness and nerve damage.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.