New combo aims to shrink head and neck tumors before surgery
NCT ID NCT07400094
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 2 trial tests whether giving a combination of the immunotherapy drug camrelizumab and two chemotherapy drugs (paclitaxel and carboplatin) before surgery can improve outcomes for people with advanced oral cavity or larynx cancer. Fifty participants will receive three cycles of the drug combo, then undergo surgery to remove the tumor. The study will measure how many tumors completely disappear or shrink significantly, and track survival over three years.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- camrelizumab (an immunotherapy drug) combined with paclitaxel and carboplatin (chemotherapy drugs)
- What this could lead to
- If successful, this approach could shrink tumors before surgery, potentially improving long-term survival and reducing the need for additional treatments after surgery.
- What could go wrong
- This is a small, early-phase study (50 people) with no control group, so results may not be definitive. Immunotherapy can cause serious side effects like inflammation of organs.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
P.A. Hertsen Moscow Oncology Research Institute
Moscow, Russia
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