Toothpaste and mouthrinse combo: which keeps fluoride in your mouth longest?
NCT ID NCT05601154
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested how much fluoride remains in saliva after using different toothpastes (over-the-counter or prescription) followed by either water or a fluoride mouthrinse. Twenty healthy adults tried four different combinations. The goal was to see which routine keeps fluoride in the mouth longest, which may help prevent cavities.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- fluoride toothpaste and mouthrinse
- What this could lead to
- If successful, this could help dentists recommend the best combination of toothpaste and mouthrinse to prevent cavities.
- What could go wrong
- This is a very small, early-phase study with only 20 healthy adults. It measures fluoride levels in saliva, not actual cavity reduction, so real-world benefits are uncertain.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
School of Dentistry, University of Michigan
Ann Arbor, Michigan, 48109, United States
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