Toothpaste and mouthrinse combo: which keeps fluoride in your mouth longest?
NCT ID NCT05601154
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested how much fluoride remains in saliva after using different toothpastes (over-the-counter or prescription) followed by either water or a fluoride mouthrinse. Twenty healthy adults tried four different combinations. The goal was to see which routine keeps fluoride in the mouth longest, which may help prevent cavities.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
fluoride toothpaste and mouthrinse
What this could lead to
If successful, this could help dentists recommend the best combination of toothpaste and mouthrinse to prevent cavities.
What could go wrong
This is a very small, early-phase study with only 20 healthy adults. It measures fluoride levels in saliva, not actual cavity reduction, so real-world benefits are uncertain.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for DENTAL CARIES are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Locations
-
School of Dentistry, University of Michigan
Ann Arbor, Michigan, 48109, United States