Wheat-Free diet shows promise for Sjogren's sufferers in small study

NCT ID NCT05644795

Completed Symptom relief Sponsor: University of Palermo Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This pilot study tested whether a wheat-free and milk-free diet could reduce symptoms in people with Sjogren's syndrome, an autoimmune disease. Thirty participants were randomly assigned to either the special diet or a control diet. After two months, those on the wheat-free diet were given wheat again to see if symptoms returned. The study measured pain, fatigue, dryness, and digestive issues using standard questionnaires.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: wheat-free and milk-free diet
What this could lead to: If it works, this could point toward a simple dietary change to help manage Sjogren's symptoms.
What could go wrong: This is a very small pilot study (30 people) with no phase, so results are preliminary and may not apply to everyone. Dietary changes can be hard to maintain and may not work for all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Sjogren syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NON CELIAC GLUTEN SENSITIVITY SJOGREN'S SYNDROME

Contacts and locations

Locations

Internal Medicine Department of the University Hospital of Palermo

Palermo, Palermo, 90127, Italy
Internal Medicine Division of the "Cervello-Villa Sofia" Hospital

Palermo, PA, 90146, Italy
Rheumatology Department of the University Hospital of Palermo

Palermo, PA, 90127, Italy

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