Wheat-Free diet shows promise for Sjogren's sufferers in small study
NCT ID NCT05644795
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This pilot study tested whether a wheat-free and milk-free diet could reduce symptoms in people with Sjogren's syndrome, an autoimmune disease. Thirty participants were randomly assigned to either the special diet or a control diet. After two months, those on the wheat-free diet were given wheat again to see if symptoms returned. The study measured pain, fatigue, dryness, and digestive issues using standard questionnaires.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
wheat-free and milk-free diet
What this could lead to
If it works, this could point toward a simple dietary change to help manage Sjogren's symptoms.
What could go wrong
This is a very small pilot study (30 people) with no phase, so results are preliminary and may not apply to everyone. Dietary changes can be hard to maintain and may not work for all patients.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Internal Medicine Department of the University Hospital of Palermo
Palermo, Palermo, 90127, Italy
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Internal Medicine Division of the "Cervello-Villa Sofia" Hospital
Palermo, PA, 90146, Italy
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Rheumatology Department of the University Hospital of Palermo
Palermo, PA, 90127, Italy