Coronary artery disorder

This trial tests whether planning coronary artery bypass grafting (CABG) using a non-invasive CT scan (CCTA) works as well as the standard invasive angiography (CAG). About 826 people with blocked heart arteries will be randomly assigned to have their surgery planned with one of …

This study looks at whether taking just one blood thinner (a P2Y12 inhibitor) is as safe and effective as taking two blood thinners (dual antiplatelet therapy) for people with stable heart disease who have a drug-coated balloon procedure without a stent. About 2,170 adults will b…

This first-in-human study tests a new device called Pulse IVL that uses sound waves to break up calcium buildup in heart arteries. Up to 15 people with coronary artery disease will receive the treatment before getting a stent. The goal is to see if the device is safe and helps op…

This study tests whether inclisiran, a twice-yearly injection that lowers cholesterol, can prevent major heart and limb events in 6,000 people who recently had artery-opening procedures. Participants receive either inclisiran or a placebo shot at the start, at 90 days, and every …

This study is checking how well a new drug-coated stent (Coroflex ISAR NEO) works in people with coronary artery disease. Researchers will follow 3,000 patients who get the stent during a routine procedure to see if it keeps arteries open safely. The goal is to confirm the stent …

This trial is testing whether a higher dose of adenosine, a drug used during cardiac MRI to stress the heart, improves blood flow imaging compared to the standard dose. The study includes 180 adults with suspected or known coronary artery disease or heart failure. By comparing th…

This study tests whether a personalized blood-thinner plan can reduce bleeding in people with coronary artery disease who have received a heart stent. About 3,944 participants will either get the usual dual antiplatelet therapy (two blood thinners) or a shorter course followed by…

This study is a registry that follows about 960 people with coronary artery disease who are treated with a special balloon coated with a drug called sirolimus. The balloon is used to open blocked heart arteries. Researchers will track heart-related events like death, heart attack…

This trial tests whether starting respiratory physiotherapy within one hour of breathing tube removal after elective coronary artery bypass surgery improves lung function and reduces complications compared to waiting until the next day. Forty adults undergoing planned heart surge…

This trial tests an implantable device called the Shockwave Reducer for people with severe, persistent chest pain (refractory angina) who cannot have standard treatments like stents or bypass surgery. About 380 participants will either receive the device or a sham procedure. The …

This study tests a drug called CSL300 in people with end-stage kidney disease who are on dialysis and have signs of inflammation. The goal is to see if it can reduce the risk of heart attacks or heart-related death. About 3110 adults will take part, and half will get the drug whi…

This study will screen 1,500 people with early signs of heart disease (plaque in arteries) to see if two common drugs—rosuvastatin and colchicine—can reduce or stabilize that plaque over two years. Participants will take pills daily and get heart-healthy lifestyle advice. The goa…

This study tests a new device called the RevCore Thrombectomy Catheter to treat blocked stents in the leg veins. About 100 adults with stents that have been in place for at least 6 weeks will be enrolled. The device is inserted into the vein to remove the blockage and restore blo…

This trial tests whether adding a low-dose blood thinner (rivaroxaban) to standard antiplatelet therapy for the first three months after a heart stent procedure can reduce the risk of future heart attacks, strokes, and other cardiovascular events in high-risk patients. Participan…

This trial compares two blood thinners, edoxaban and apixaban, in people who have both atrial fibrillation (an irregular heartbeat) and coronary artery disease (narrowed heart arteries). Both drugs help prevent blood clots, but they are taken differently and may have different ri…

This study looks at how a special balloon called the OPN balloon is used to open severely hardened or blocked heart arteries. Researchers will track 300 adults who need this procedure to see how well it works and what problems might happen. The goal is to learn the best ways to u…

This study compares two medicated stents (tiny mesh tubes) used to open blocked heart arteries in people having a heart attack or unstable angina. About 2,100 participants will receive either a sirolimus-eluting stent (ihtDEStiny) or an everolimus-eluting stent (Xience). Research…

This study tests whether using a CT scan to guide heart stent placement is better than the current standard (IVUS ultrasound) for people with hardened, calcified coronary arteries. About 700 adults with evidence of reduced blood flow to the heart will be randomly assigned to one …

This study tests a drug called lepodisiran in 252 adults with high levels of Lp(a), a protein linked to heart disease. Participants must have heart disease or be at risk for a first heart event. The drug is given as an injection and compared to a placebo to see if it reduces plaq…

This study investigates whether aggressive lipid-lowering therapy can reduce plaque buildup in the heart arteries of melanoma patients starting immune checkpoint inhibitors (ICIs). Participants with plaque detected on a heart CT scan are randomly assigned to either usual care or …

This trial tests whether using a supraglottic airway (a mask-like device) instead of a breathing tube during heart surgery can reduce lung complications and speed recovery. Adults having elective heart valve surgery or bypass will be randomly assigned to either the nonintubated a…

This study tests a new type of stent (a small mesh tube) for people with heart disease who also take blood thinners. These patients have a high risk of bleeding when they also need anti-clotting drugs after stent placement. The new stent is designed to allow a shorter course of a…

This study looks at two ways to treat blocked large heart arteries (≥3.5 mm) in people with coronary artery disease. One method uses a drug-coated balloon, the other a drug-releasing stent. The goal is to see which helps the artery relax and function better 8 months after treatme…

This study tests two ways to treat hardened calcium deposits in heart arteries. After using sound waves to break up the calcium, doctors will either place a drug-coated balloon or a drug-coated stent. The trial will follow 128 patients for 9 months to see which approach keeps art…

This study tests a drug called YN001 in 456 adults with coronary atherosclerosis (plaque buildup in heart arteries). Participants receive weekly injections of YN001 or a placebo for 13 weeks. The main goal is to see if YN001 reduces plaque volume in the arteries, as measured by a…

This study tests a new device that uses sound waves to break up calcium deposits in heart arteries before placing a stent. About 408 adults with coronary artery disease will receive this treatment. The goal is to see if the device is safe and effective at clearing blockages to im…

This trial is testing a new coronary extension catheter designed to help doctors deliver balloons and stents more easily during percutaneous coronary intervention (PCI) for coronary artery disease. The study will enroll about 69 adults who need PCI and for whom the catheter is pl…

This study tests whether giving thiamine (vitamin B1) during coronary artery bypass surgery can reduce the memory and thinking problems that sometimes follow the procedure. Older adults with coronary heart disease who are scheduled for bypass surgery and have low thiamine levels …

This early-stage trial tests a single IV dose of VERVE-102, a gene-editing drug designed to permanently lower LDL (bad) cholesterol by turning off a specific gene in the liver. It involves 85 adults with inherited high cholesterol or early heart disease who still need lower chole…

This trial tests whether a smartphone app called HeartCheck can help people who have recently survived a heart attack better manage their blood pressure, cholesterol, blood sugar, and smoking habits. The app provides education, reminders, and easy-to-understand goals to support m…

This large trial tests two types of intravenous fluids given during heart surgery: hydroxyethyl starch (HES) and balanced crystalloids. The goal is to see which fluid leads to fewer serious kidney problems, such as kidney failure or death. About 1,292 adults having heart surgery …

This registry tracks 5,000 people with coronary artery disease who receive one of three drug-eluting stents during angioplasty: Biolimus, Everolimus, or Zotarolimus. Researchers will compare rates of heart-related death, heart attack, and repeat procedures over two years. The goa…

This study looks at the best timing for opening blocked arteries in people having a certain type of heart attack (NSTEMI) who have multiple blockages. About 1,014 participants will be randomly assigned to have all blockages fixed during the same procedure or to wait a few days be…

This trial tests whether a structured physiotherapy program started at least two days before coronary artery bypass grafting (CABG) and continued after surgery can improve recovery in high-risk patients. Participants are adults scheduled for elective CABG who meet at least three …

This study tests a new device called Freesolve, a temporary magnesium scaffold that props open blocked heart arteries and then dissolves over time. About 1,859 people with up to two new blockages will receive either this scaffold or a standard permanent stent. The goal is to see …

This study tests a new balloon coated with sirolimus (Virtue SAB) against an existing balloon coated with paclitaxel (AGENT DCB) for treating in-stent restenosis — when a previously placed stent in a heart artery becomes blocked again. About 740 people with one re-narrowed stent …

This study is testing whether a drug-coated balloon is as good as a drug-eluting stent for treating complex coronary artery disease in high-risk patients. About 2,184 participants will be randomly assigned to receive one of the two treatments. The main goal is to see if the ballo…

This study tests whether combining aerobic exercise with strength training helps people recover better after coronary artery bypass graft (CABG) surgery. Participants, aged 30 to 60 and cleared for phase II cardiac rehab, are randomly assigned to aerobic exercise alone or aerobic…

This study tests a new version of the clot-dissolving drug tenecteplase, coated with platelet membranes, to see if it targets blood clots more effectively. Researchers will apply the coated drug to blood clots made from samples taken from people with coronary artery disease and h…

This trial tests whether an experienced doctor's eye, guided by standard X-ray images, can place a heart stent as well as using a special ultrasound probe inside the artery. The study focuses on the left main coronary artery, a critical vessel. All patients receive the same type …

This study tests a new device called the Elevate™ heart pump in 290 people who need high-risk angioplasty (a procedure to open blocked heart arteries). The pump helps keep blood flowing during the procedure. The goal is to see if it is safer and works better than current methods.…

This early study tests a device called the A-FLUX Reducer, which is implanted into a vein in the heart to help blood flow. It is for people with chest pain caused by problems in the heart's tiny blood vessels (microvascular dysfunction). The study will enroll 30 adults and focus …

This study compares two ways to place stents in the left main coronary artery when there is a blockage at the opening of a branch. One method places a stent only in the blocked branch, while the other extends a stent from the main artery into the branch. Researchers will track 10…

This study compares a new temporary heart pump called the Supira System to the existing Impella pump in 358 patients undergoing high-risk coronary stenting. The goal is to see if Supira is as safe and effective at supporting the heart during the procedure. Participants are random…

This study tests a new type of heart stent made from magnesium that slowly dissolves over time. It is designed for people with long blockages in their heart arteries. The goal is to see if the stent is safe and works well at keeping arteries open for up to 12 months. About 100 pa…

This study tests if a special device called orbital atherectomy can better prepare hardened (calcified) heart artery blockages for stenting compared to standard balloon treatment. About 200 adults with severe blockages will be randomly assigned to one of two groups. The goal is t…

This study looks at how safe and effective a special stent (VBX) is for treating blocked arteries near the aorta in the lower belly. About 158 people who already had this stent placed at least a year ago will be followed. The goal is to see if the artery stays open and if there a…

This trial compares two different dual blood pressure medications in people aged 50–70 with high blood pressure and heart disease who have just received a heart stent. Participants are randomly assigned to one of two drug combinations: losartan plus hydrochlorothiazide or amlodip…

This trial compares two blood thinners—rivaroxaban (Xarelto) and warfarin—in children over 2 years old who have giant coronary artery aneurysms caused by Kawasaki disease. The goal is to see if rivaroxaban is safer and as effective as warfarin at preventing blood clots, major ble…

This study tests whether using a computer simulation (virtual stenting) before placing stents in heart arteries can lead to better outcomes than the usual method guided by X-ray images alone. About 1,472 adults with coronary artery disease will be randomly assigned to either the …

This study looks at how well different drug-eluting stents work in real-world patients with coronary artery disease. Researchers are comparing newer stents to older ones to see which are safest and most effective. The study includes up to 50,000 people who need a stent to open bl…

This early-stage trial tests whether an experimental drug called UDP-003 is safe in healthy volunteers and people with heart disease. Researchers will give single or multiple doses of the drug or a placebo and monitor for side effects. The study includes 84 participants and is th…

This pilot study tests whether the drug colchicine can reduce artery plaque in 120 heart attack survivors who have a specific genetic change (TET2-CHIP). Participants take colchicine or standard care for 12 months. The goal is to see if this genetic marker can guide personalized …

This study tests a new device called ShockFast IVL against an existing one, ShockWave IVL, for treating hardened calcium deposits in heart arteries. Both devices use sound waves to break up calcium so a stent can be placed more easily. The trial will involve 120 adults with coron…

This study compares two stomach-acid-lowering drugs—tegoprazan and rabeprazole—in about 3,300 heart disease patients who take blood thinners and are at high risk for stomach bleeding. The goal is to see if tegoprazan works as well as rabeprazole at preventing serious gut problems…

This study is tracking 2,000 people with coronary artery disease who receive Ultimaster stents during routine care. Researchers want to see how often serious heart problems like death, heart attack, or the need for another procedure happen within a year. The goal is to understand…

This trial tests a 12-week home-based digital cardiac rehabilitation program for people with coronary artery disease. It aims to improve heart health, reduce hospital visits, and enhance quality of life, especially for older adults, women, and those with other health issues. The …

This study is testing a new heart stent called Coroflex ISAR NEO in 1,000 people with narrowed heart arteries. The goal is to see how safe and effective it is compared to other stents in everyday medical practice. Researchers will track major heart problems like death, heart atta…

This study is tracking 1,000 people who receive the DESyne X2 drug-eluting stent to treat narrowed or blocked coronary arteries. Researchers are monitoring how often patients experience serious heart events like death, heart attack, or the need for another procedure. The goal is …

This study compares two advanced heart procedures—stenting guided by imaging and blood flow tests (PCI) versus bypass surgery (CABG)—in 1,500 people with diabetes and three blocked coronary arteries. The goal is to see which approach better prevents major events like death, heart…

This study tests whether adding an implantable cardioverter defibrillator (ICD) to standard medication helps people with variant angina who have survived a sudden cardiac arrest. About 140 adults will be randomly assigned to get either an ICD plus medication or medication alone. …

This study is testing a long version of the Ultimaster Nagomi stent in people with long blockages in their heart arteries. About 1,039 participants will receive the stent and be followed for one year to see if it works well and stays safe. The goal is to see if one long stent can…

This study tests whether using artificial intelligence (AI) to analyze ultrasound images during heart stent placement can reduce future heart problems. About 3,000 adults with coronary artery disease will receive a stent guided by AI-enhanced intravascular ultrasound. Researchers…

This pilot study is testing whether the anti-inflammatory drug colchicine can lower inflammation and reduce the risk of atrial fibrillation (an irregular heartbeat) after coronary artery bypass surgery. 24 adults scheduled for bypass surgery will be randomly assigned to receive e…

This study follows 840 people with a completely blocked coronary artery (chronic total occlusion) for at least 10 years. Half received a drug-eluting stent, and half got optimal medical therapy alone. Researchers will compare rates of death, heart attack, stroke, and repeat proce…

This study compares two methods of guiding stent placement in the left main coronary artery: standard angiography versus fractional flow reserve (FFR), which measures blood pressure across the blockage. About 960 adults with significant left main artery disease will be randomly a…

This study tests whether a home-based cardiac rehab program delivered through a mobile app can reduce plaque buildup in the heart arteries of people with mild to moderate blockages. 176 participants will either get the app-based program (with exercise plans, diet advice, and ment…

This study looks at whether the diabetes drug dapagliflozin can improve how well the right side of the heart works after off-pump coronary bypass surgery. Researchers will measure heart function in 72 patients with weak hearts before and after 6 months of taking the drug. The goa…

This phase 3 trial is testing whether atorvastatin, a common cholesterol drug, is safe and can reduce inflammation in children with Kawasaki disease who also have coronary artery abnormalities. The study will enroll 9 children and give them different doses of atorvastatin for 6 w…

This study looks at whether adding oregano and basil leaves to the diet can lower inflammation and improve cholesterol in people who have recently had unstable angina. About 70 participants will eat these herbs and have their blood and urine tested. The goal is to see if these co…

This study tests a special stent called PK Papyrus to repair holes (perforations) that can happen in heart arteries during procedures. About 41 people with such tears will receive the stent. The goal is to see how safe and effective it is at sealing the artery and preventing comp…

This study tests whether adding evolocumab, a cholesterol-lowering drug, to standard care can slow or stop plaque buildup in heart arteries after a heart attack. About 233 adults aged 40-75 who recently had a heart attack or unstable angina will receive either evolocumab plus sta…

This study tests whether using a tiny ultrasound camera inside the leg arteries during a procedure to open blockages can prevent major problems like amputation or the artery narrowing again. About 772 adults with severe peripheral artery disease (chronic limb-threatening ischemia…

This study compares two ways to treat long, diffuse blockages in heart arteries. One method uses a temporary scaffold and drug-coated balloons that leave no permanent metal behind. The other uses standard metal stents. Researchers will check how well blood flow improves right aft…

This study compares two treatments for narrowed small heart arteries: paclitaxel-coated balloons versus drug-eluting stents. About 1,380 people with stable or unstable chest pain will be randomly assigned to one of two balloon types or a standard stent. The goal is to see if ball…

This study tests whether giving two steroids (hydrocortisone and fludrocortisone) to high-risk patients before heart surgery can lower the chance of serious complications like kidney injury and lung problems. The trial will include 196 adults with a EuroSCORE II above 4% who are …

This study looks at whether it is safer to stop or continue taking direct oral anticoagulants (blood thinners) during planned heart procedures like angiography or stent placement. About 1,270 adults with atrial fibrillation and coronary artery disease will be randomly assigned to…

This trial tests a special cannula that captures debris during high-risk heart valve surgery. The goal is to see if it reduces the chance of stroke, kidney injury, and delirium. About 842 patients aged 60 and older will be randomly assigned to receive either the new device or a s…

This study tests whether dapagliflozin, a diabetes medication, can slow or reverse plaque buildup in the heart arteries of people with type 2 diabetes. About 144 adults with stable heart disease will take either the drug plus standard care or standard care alone for 18 months. Re…

This study looks at whether the heart medication Camzyos (Mavacamten) can improve blood flow to the heart muscle in people with hypertrophic obstructive cardiomyopathy (HOCM). Researchers will use special PET-CT scans to measure blood flow before and after 12 months of treatment.…

This study tests whether a thinner tube (6-French Glidesheath Slender) can make heart procedures safer for people with small wrist arteries. About 594 adults with coronary artery disease will be randomly assigned to get the standard tube or the thinner one through a wrist access …

This study tests a new type of heart stent that dissolves over time, unlike permanent metal stents. The trial will enroll 117 people with stable coronary artery disease to see if the new stent, placed with special imaging guidance, works safely and effectively. The goal is to red…

This study looks for the best type and dose of blood thinner (P2Y12 inhibitor) for people who have had a heart stent placed. After an initial period on two blood thinners, patients switch to one. The goal is to find a dose that keeps blood clotting at a safe level—not too high (w…

This study tests whether a fabric-covered stent (GORE VBX) works better than standard bare metal stents for people with severe blockages in the iliac arteries, which supply blood to the legs. About 244 participants with leg pain or tissue loss will be randomly assigned to receive…

This study tests a personalized diet and exercise program guided by a smartphone app in 140 obese adults with coronary heart disease. Participants receive custom meal plans and daily weight tracking to help them lose weight safely. The goal is to see if this approach improves wei…

This study compares two strategies to reduce bleeding risk in people who take two blood thinners after having a stent placed in their heart. The goal is to see if lowering the dose of one drug works as well as switching to a different drug. About 78 adults who have had a stent wi…

This study compares two common heart procedures—bypass surgery (CABG) and stenting (PCI)—in 358 people with weak hearts (ejection fraction 40% or less) and multiple blocked arteries. The goal is to see which approach leads to better survival, fewer heart attacks or strokes, and i…

This study looks at whether a traditional Chinese herbal prescription called Fuzheng Yangxin can help people recover more quickly after coronary artery bypass grafting. Researchers will follow 300 patients with a specific post-surgery syndrome (Qi-Yin deficiency) to see if the he…

This study tests an inhaled medicine called Aroxxen to see if it can reduce heart damage during and after a common procedure to open blocked heart arteries (stent placement). About 180 adults with coronary artery disease will receive either Aroxxen or standard care. Researchers w…

This pilot study tests whether canagliflozin, a diabetes medication, can reduce inflammation in the arteries of people with type 2 diabetes and stable coronary artery disease. Researchers will compare the drug to a placebo over 6 months in 16 participants. The main goal is to mea…

This study looks at whether adjusting the dose of the blood thinner cangrelor based on individual test results can better control clotting in people with coronary artery disease who are waiting for surgery. About 50 adults will receive either a standard or tailored dose to find t…

This trial tests a new type of stent (Supraflex Cruz) combined with a shorter course of blood thinners (only 1-3 months of dual therapy, then just one drug) for people with a blockage in the left main coronary artery. The goal is to see if this approach reduces bleeding risks whi…

This study is testing absorbable scaffolds—temporary tubes that support blocked heart arteries and then dissolve over time—in over 1,100 people with coronary artery disease. Researchers are tracking heart-related deaths, heart attacks, and the need for repeat procedures to see ho…

This study compares two medical devices used to break up hard calcium deposits in heart arteries before placing a stent. It involves 50 adults with coronary artery disease who will be randomly assigned to receive either orbital atherectomy or intravascular lithotripsy. The goal i…

This study looks at two ways to treat blocked heart arteries in people aged 18 to 68. One uses a drug-coated balloon, and the other uses a temporary scaffold. The goal is to see which approach works better over time, with fewer heart problems or need for repeat procedures. About …

This study is testing a special stent called Supraflex Cruz in 1000 people who have blockages in more than one heart artery. The stent is coated with a drug (sirolimus) that slowly releases to help keep the artery open, and the coating dissolves over time. Researchers want to see…

This study looks at 110 women with blocked heart arteries who need bypass surgery. It compares using the arm artery versus a leg vein (prepared with a special no-touch method) to reroute blood flow. The goal is to see which graft stays open longer and leads to fewer heart problem…

This study tests an investigational drug called SRSD107 in people with chronic coronary artery disease or peripheral arterial disease. The goal is to see if it safely reduces a protein involved in blood clotting, which may lower the risk of dangerous clots. About 104 adults will …

This study tests two strategies for treating people with high-risk coronary artery disease. One strategy uses detailed imaging of plaque inside the arteries to decide which blockages need a stent or bypass. The other uses a standard blood flow test. About 1,944 participants will …

This registry is tracking 10,000 patients with coronary artery disease who receive the Supraflex sirolimus-eluting stent during routine care. The goal is to see how well the stent works in everyday practice, measuring outcomes like heart-related death, heart attacks, and the need…

This study tests whether colchicine, an inexpensive anti-inflammatory drug used for gout, can prevent heart attacks, strokes, and death in heart disease patients undergoing major surgery. Researchers will give the drug to 700 veterans before and after their operation. The goal is…

This study compares a new artificial intelligence (AI) method that uses X-ray images to guide heart artery stenting against the standard invasive method. About 2100 adults with narrowed heart arteries will be randomly assigned to one of the two approaches. The goal is to see if t…

This trial tests whether using two or more arterial grafts during heart bypass surgery is better than using just one. About 4,300 patients will be randomly assigned to receive either a single arterial graft or multiple arterial grafts. The goal is to see if multiple grafts reduce…

This study tests a new surgical method for heart bypass surgery that avoids touching the aorta, aiming to reduce brain complications like silent strokes. About 380 adults with coronary artery disease will be randomly assigned to either the new no-touch technique or the standard m…

This study is testing whether giving the blood thinner cangrelor through a vein during minimally invasive heart bypass surgery is safe and practical. The goal is to prevent dangerous blood clots while the patient is on the operating table. Researchers will compare 30 patients rec…

This study compares two blood-thinning approaches in 326 adults with acute coronary syndrome and coronary artery ectasia (enlarged heart arteries). One group gets standard dual antiplatelet therapy (aspirin plus clopidogrel), while the other gets clopidogrel plus the anticoagulan…

This study looks at two types of stents (small mesh tubes) placed in heart arteries to keep them open. It focuses on patients with acute coronary syndrome who also have a high risk of bleeding. The goal is to see how well the blood vessel heals around the stent one month after th…

This study tests a new device that freezes dangerous plaque in heart arteries to see if it can reduce blockages and prevent future heart problems. About 30 people with stable angina or recent heart events will receive the freezing treatment during a planned procedure. Researchers…

This study tests whether using a blood pressure cuff to create brief periods of reduced blood flow (remote ischemic conditioning) combined with daily mindfulness meditation can lower the risk of heart attacks, heart failure, and chest pain in people with coronary artery disease w…

This study tests a new way of caring for people with new-onset stable chest pain and suspected coronary artery disease. Instead of using a standard invasive heart catheterization, the new model uses a CT scan of the heart, which is less burdensome. The study will include about 3,…

This study is testing whether using multiple arteries during coronary bypass surgery improves outcomes for women compared to using just one artery. About 2,300 women will be randomly assigned to receive either a single arterial graft or multiple arterial grafts. The goal is to se…

This study compares a newer, minimally invasive heart-lung machine (MiECC) to the standard machine used during heart surgery. Researchers want to see if the newer machine reduces serious problems like heart attack, stroke, or kidney injury. About 1,300 adults having elective hear…

This study aims to see if using tiny cameras inside the heart's arteries during stent placement leads to better outcomes for people with complex coronary artery disease. About 11,000 adults in the Netherlands who need a stent for severe blockages will be included. The goal is to …

This study is testing whether a 12-week supervised exercise program can improve artery health and reduce inflammation in people with coronary artery disease. Fifty patients aged 40-70 will do aerobic, resistance, and flexibility exercises three times a week. Researchers will meas…

This study tests if using a single device (orbital atherectomy) to sand away calcium in heart arteries works as well as letting doctors choose from several methods based on each patient's calcium type. About 310 adults with severely calcified arteries will be randomly assigned to…

This study tests whether doing a follow-up CT scan of the heart arteries in people with non-obstructive coronary artery disease can help doctors adjust treatment to better control cholesterol and prevent heart attacks, strokes, or death. About 3,100 participants will be randomly …

This study tests whether adding a Chinese herbal medicine called Yiyang Huoluo Decoction to standard heart medications can improve symptoms and blood vessel health in older adults with coronary heart disease and atherosclerosis. About 30 participants aged 50-75 will be randomly a…

This study tests whether ziltivekimab, a monthly injection that reduces inflammation, can improve artery health in people who have recently had a heart attack. About 332 participants will receive either the drug or a placebo, alongside standard care. Researchers will use special …

This study looks at whether two common statins (pitavastatin and rosuvastatin) affect male sex hormones and erectile function in men aged 40-65 with high heart risk. Researchers will monitor 150 men for 6 months, checking hormone levels, erectile function, and blood vessel health…

This study compares two treatments for people with completely blocked heart arteries (chronic total occlusions). One group gets a drug-coated balloon, with or without a stent; the other gets standard stents. The goal is to see if the balloon approach keeps arteries open just as w…

This study tests whether the drug ranolazine can protect the tiny blood vessels in the heart after a heart attack. One hundred adults who had a major heart attack and have at least one other blocked artery will receive either ranolazine plus standard care or standard care alone. …

This study compares two blood thinner combinations in adults over 65 who have had a heart attack or unstable angina and received a stent. One group gets indobufen plus ticagrelor, the other gets aspirin plus ticagrelor. The goal is to see which combo better prevents heart-related…

This study looks at two strategies to reduce bleeding in people with coronary artery disease who have had a stent placed and are on blood thinners. One approach is to switch from a stronger blood thinner to a milder one while keeping aspirin. The other is to stop aspirin and stay…

This study tests two ways to break up heavy calcium buildup in heart arteries before placing a stent: a super high-pressure balloon versus a special shockwave balloon (lithotripsy). About 78 adults with severe coronary artery disease will be randomly assigned to one method. The g…

This study tests whether a reduced dose of the blood thinner prasugrel (5 mg), taken alone without aspirin, is safe and effective for patients who have had a stent placed for heart disease. Researchers will compare this approach to standard dual antiplatelet therapy (aspirin plus…

This registry is following 10,000 people who receive the BioFreedom Ultra stent, a device coated with the drug biolimus A9 to keep heart arteries open. The goal is to see how well the stent works in real-world patients, not just in controlled trials. Researchers will track proble…

This study is testing a special balloon coated with the drug sirolimus to treat blocked heart arteries. The balloon is inflated inside the artery to push the blockage aside and release the drug, which helps prevent the artery from narrowing again. Researchers will follow over 1,1…

This study tests whether a drug-coated balloon works as well as a drug-eluting stent for people with severe calcium deposits in their heart arteries. After using special tools to break up the calcium, 656 participants will be randomly assigned to one of the two treatments. Resear…

This study looks at how different types of aerobic exercise affect blood vessel health in people with ischemic heart disease (such as after a heart attack or angina). Researchers will compare high-intensity interval training with short bursts, long bursts, and moderate-intensity …

This study tests whether a genetic score (ABCD-GENE) can help doctors choose the right blood thinner for patients after a heart stent. Currently, patients take two blood thinners for months. The score would guide whether to switch to a milder drug or drop one of the two. The tria…

This study tests whether a remote monitoring program can help people with coronary artery disease recover better after a heart procedure called PCI. About 200 participants will either get standard care or use a smartphone app with text follow-up and health coaching. The goal is t…

This study tests a new medicine called YN001 in people with coronary atherosclerosis (hardening of the arteries in the heart). The goal is to see if YN001 can reduce plaque buildup in the arteries when added to standard care. About 24 adults in Australia with at least one blocked…

This study follows 100 people with coronary artery disease who have already been treated with the Essential Pro device. Researchers want to confirm the device is safe and works as intended, meeting new European safety rules. The main goal is to see if the device prevents serious …

This study tests a temporary heart pump called the Supira System in 45 people with heart failure and severe coronary artery disease who need high-risk angioplasty. The pump is inserted through a leg artery to help the heart pump blood during and after the procedure. Researchers w…

This study compares a new dissolvable heart stent (Firesorb BRS) to a standard metal stent in 2000 people with coronary artery disease. The dissolvable stent is designed to support the artery temporarily and then disappear, potentially avoiding long-term risks of permanent stents…

This study tests whether a stronger blood thinner (prasugrel) combined with aspirin works better than the standard combo (clopidogrel plus aspirin) in heart disease patients undergoing complex artery stenting. About 3,500 adults will be enrolled to see if the stronger combo reduc…

This study tests whether custom pressure-guided elastic bandages can prevent leg swelling and other complications after coronary artery bypass surgery. About 106 adults having bypass surgery with leg vein removal will be split into two groups: one gets the custom bandages, the ot…

This study tests whether adding a powerful cholesterol-lowering drug (PCSK9 inhibitor) to standard treatment can prevent heart attacks, strokes, and death in people with high-risk coronary plaques seen on CT scans. About 3,600 adults with at least one severely narrowed or high-ri…

This study compares two blood thinners, prasugrel and ticagrelor, when used alone after stopping aspirin in people with coronary artery disease who have had a stent placed. About 48 participants will take one of the two drugs for three weeks to see which one better prevents blood…

This study compares two blood thinners—low-dose ticagrelor and standard clopidogrel—in 50 stable heart disease patients getting a stent. The goal is to see which drug better prevents blood clots around the time of the procedure. Participants take the assigned drug plus aspirin fo…

This study looks at two ways to treat people with chronic coronary artery disease (narrowed heart arteries). One group gets a special CT scan to find blocked arteries and then receives procedures like stents or bypass surgery. The other group gets only medications and lifestyle a…

This study looks at whether using a temporary mechanical heart pump during a high-risk heart procedure (PCI) can improve safety and outcomes. About 98 adults with weak hearts and complex blockages will be randomly assigned to receive the pump or standard care. The goal is to see …

This study compares two ways to open completely blocked heart arteries (chronic total occlusion): a drug-coated balloon versus a drug-eluting stent. About 200 adults with coronary artery disease will be randomly assigned to one treatment. The goal is to see which approach keeps t…

This study tests a special balloon coated with two drugs to open blocked heart arteries in people with chest pain or minor heart attacks. The balloon is used instead of placing a new stent. About 30 participants will be followed for 12 months to see if the artery stays open and i…

This study tests a pharmacy-led program for low-income patients with multiple chronic conditions like diabetes, heart disease, and depression. After leaving the hospital, participants get their medications with no copay, delivery to their bedside and home, and help from a pharmac…

This study tests whether taking ezetimibe along with a high-dose statin (atorvastatin) works better than the statin alone for people who have had a heart stent placed. About 4,300 participants will be followed for three years to see if the combination reduces deaths, heart attack…

This phase 2 trial tests whether meplazumab, an antibody given by IV, can reduce inflammation and fatty buildup in the arteries of people with coronary artery disease. The study involves 18 participants and will compare three different doses to a placebo. It is an early, explorat…

This study tests whether a team of healthcare professionals using a special algorithm can lower 'bad' cholesterol (LDL-C) more effectively than standard care in people with heart or blood vessel disease. About 100 adults with high cholesterol and known vascular disease will be ra…

This study tests whether adding low-dose colchicine (0.5 mg daily) to standard heart treatments can lower the risk of major heart problems like heart attacks and strokes. About 3,800 adults with stable coronary artery disease and non-flow-limiting plaque will be randomly assigned…

This study looks at whether taking just one blood thinner (single antiplatelet therapy) is safer and as effective as taking two (dual antiplatelet therapy) in older adults or those at high risk of bleeding who have had a balloon procedure to open blocked heart arteries. About 576…

This study looks at whether adding resistance training (like squats and pulling exercises with weights) to standard cycling workouts can improve fitness and muscle mass in women with coronary artery disease. Fifty women who have had a heart attack or heart procedure will take par…

This study tests new plastic tubes (cannulas) used to connect patients to a heart-lung machine during heart surgery. The trial has two parts: first, a small safety check, then a larger comparison with existing tubes. About 80 adults having planned heart surgery will take part to …

This study tests whether a drug-coated balloon can reduce fatty deposits in heart arteries better than standard medications alone. Researchers will enroll 400 adults who recently had a heart-related event (acute coronary syndrome). Participants will get either the balloon treatme…

This study tests whether a new pressure microcatheter works as well as the standard pressure wire for guiding stent placement in people with coronary artery disease. About 2,500 participants will be randomly assigned to one of the two devices during their procedure. The main goal…

This study compares a new shockwave technique to standard balloon or cutting methods for preparing severely calcified heart arteries before placing a stent. About 666 adults with coronary artery disease will take part. The goal is to see if shockwave reduces major heart and brain…

This study tests two methods to fix a common problem: a heart stent that hasn't opened fully (underexpansion). One method uses a balloon to push the stent open, the other uses shock waves (lithotripsy) to crack the blockage. About 80 people with narrowed stents will be randomly a…

This study looks at using a special balloon coated with medicine to open completely blocked heart arteries. About 30 people with chest pain or other symptoms will get this treatment. Doctors will use ultrasound and pressure measurements to check how well the artery opens and stay…

This study is tracking 50,000 people with coronary artery disease who receive drug-eluting stents during a routine procedure to open blocked heart arteries. Researchers want to see how well these stents prevent major heart problems like death, heart attack, or the need for anothe…

This study tests whether taking a low dose of colchicine (a medicine used for gout) every day for a year can prevent the new blood vessels created during heart bypass surgery from failing. About 100 adults who recently had bypass surgery will take colchicine or no extra treatment…

This study compares a new type of heart stent (XIENCE Skypoint) with other drug-coated stents in 2000 people with coronary artery disease. The goal is to see which stent is more effective and safer in real-world use. Participants will be followed for at least one year to track ou…

This study tests whether rapidly adjusting cholesterol-lowering medications, based on frequent blood tests, helps heart disease patients reach their LDL cholesterol targets faster. Researchers will enroll 1000 adults with coronary artery disease and monitor their cholesterol leve…

This study is testing whether taking clopidogrel (a blood thinner) every day for at least 5 years can prevent heart attacks, strokes, and death in people who have early signs of coronary artery disease on scans but no symptoms. About 11,000 adults aged 40 and older will be assign…

This study tests whether adding inclisiran (a twice-yearly injection) to standard care lowers LDL cholesterol more than standard care alone in 520 patients who recently had a heart attack, stroke, or urgent heart procedure. Participants are randomly assigned to receive inclisiran…

This study is tracking 1,500 people with coronary artery disease who are treated with a drug-eluting balloon during angioplasty. The balloon releases a medicine (paclitaxel) to help keep the artery open. Researchers are checking how well it works and if it is safe over the long t…

This study is tracking 2,000 people with coronary artery disease who receive either a Synergy XD or Synergy Megatron stent during a routine procedure to open blocked heart arteries. Researchers want to see how these stents perform in everyday medical practice compared to other dr…

This study looks at 120 people with diabetes who have blocked heart arteries. It compares using a drug-coated balloon together with a drug-eluting stent versus using either device alone. The goal is to see which approach keeps arteries open best after 6 months.

This study compares two methods for guiding a second stent procedure in people whose drug-coated stents have re-narrowed. One method uses standard X-ray (angiography), the other adds detailed imaging from inside the artery. The goal is to see which approach leads to fewer major h…

This study looks at whether taking two blood thinners (ticagrelor plus aspirin) is better than aspirin alone for keeping bypass grafts open in people who had heart surgery after a heart attack. About 360 participants will be followed for 1 to 3 years, and their grafts will be che…

This study tests whether empagliflozin, a diabetes drug, can reduce inflammation after a heart stent procedure. 100 patients with stable coronary artery disease will take either empagliflozin or a placebo for three days before their scheduled stent placement. Researchers will mea…

This study is tracking 508 patients with multivessel coronary artery disease who received the SUPRAFLEX CRUZ stent during routine care. Researchers are monitoring for heart-related events like heart attacks, repeat procedures, and heart function over 12 months. The goal is to con…

This study tests whether a device called Bioboosti, which delivers pulsed electromagnetic fields, can improve blood flow to the heart in people with coronary artery disease. Researchers will measure blood flow during stress and track symptoms like chest pain and exercise capacity…

This study tests whether briefly inflating a blood pressure cuff on the arm before a heart procedure can protect the kidneys and heart in people with congestive heart failure. About 240 participants will be randomly assigned to receive either the real cuff inflations or a sham ve…

This study is testing whether metformin, a common diabetes medicine, can reduce the risk of death, heart attacks, and strokes in veterans who have pre-diabetes and already have heart or blood vessel disease. About 7,410 participants will receive either metformin or a placebo. The…

This study is for women under 75 who need heart bypass surgery for three blocked arteries. It compares two types of grafts for the second most important artery: a leg vein harvested with a special 'no-touch' technique versus a wrist artery. The goal is to see which graft stays op…

This study tests a new device called the SoniCracker IVL, which uses tiny shockwaves to break up hard calcium deposits in heart arteries. The goal is to make it easier to place stents and improve blood flow. About 40 adults with calcified coronary arteries will be enrolled. Resea…

This study is testing whether drug-coated balloons work as well as drug-eluting stents for people with blocked heart arteries. About 321 participants will be randomly assigned to one of three treatments. The main goal is to see how well blood flows through the treated arteries af…

This study tests whether an artificial intelligence (AI) smartphone app can help adults with coronary heart disease exercise safely at home after hospital discharge. About 200 low-risk patients will either use the AI platform with a wristband or receive standard care. The goal is…

This study compares two types of drug-coated balloons (Selution sirolimus vs. SeQuent Please Neo paclitaxel) to treat narrowed coronary arteries in medium-small vessels. About 140 adults with stable angina or stabilized acute coronary syndrome will be enrolled. The main goal is t…

This large trial tests whether the sedative dexmedetomidine can prevent long-term memory and thinking problems that often follow heart surgery. Researchers will give the drug to 2,400 adults aged 60 and older during and after their operation, then track their cognitive function f…

This study compares two newer diabetes drugs, semaglutide and dapagliflozin, against the standard drug metformin in 300 people with pre-diabetes and coronary artery disease. The goal is to see which drug best slows or reverses the buildup of plaque in heart arteries over 24 month…

This study looks at whether people with chronic heart disease and a high risk of bleeding can stop taking antiplatelet drugs (blood thinners) one year after a balloon angioplasty procedure. Researchers will compare those who stop versus those who continue the medication, tracking…

This study tests whether Yangxinshi tablets can improve outcomes for people with coronary heart disease and heart dysfunction. About 2,700 participants aged 40-80 will receive the tablet or a placebo. The goal is to see if the tablets reduce serious heart events like death, strok…

This study compares two anesthetics—desflurane gas and propofol—during coronary artery bypass surgery. Researchers want to see if desflurane helps prevent major heart problems like heart attack or heart failure within 30 days after surgery. About 3,560 adults having planned bypas…

This study tests whether a drug-coated balloon works as well as a drug-eluting stent for people with complex blockages in heart arteries. About 520 adults with coronary artery disease will be randomly assigned to one of the two treatments. The goal is to see which approach leads …

This registry is tracking over 1,100 people with coronary artery disease who receive resorbable magnesium scaffolds—stents that slowly dissolve over time. The goal is to see how well these devices work in everyday medical practice, focusing on safety and whether they keep arterie…

This study compares two blood-thinning strategies after a combined heart bypass and endarterectomy procedure. About 202 adults with widespread coronary artery disease will receive either standard dual antiplatelet therapy or that therapy plus warfarin. The goal is to see if addin…

This study tests whether adding berberine, a natural compound, can improve blood thinning in heart patients who already take aspirin and clopidogrel after a stent procedure. About 64 adults will receive either standard treatment or berberine at increasing doses for 12 weeks. The …

This study tests whether a comprehensive treatment plan can reduce heart attacks and other serious events in people with rapidly-progressive coronary artery disease tied to inflammation. Researchers will compare each participant's outcomes before and after treatment. The study en…

This study looks at whether SGLT2 inhibitors (drugs like empagliflozin and dapagliflozin, typically used for diabetes) can prevent acute kidney injury caused by contrast dye used in heart X-rays and stent procedures. Researchers will review records of 4,000 patients who had these…

This study looks at whether switching from a standard blood thinner (clopidogrel) to a lower-dose version of another (prasugrel) can better control blood clotting in heart patients who have both high bleeding and high clotting risks after getting a stent. About 40 adults who have…

This study tests whether a cardiometabolic clinic can help obese adults with heart disease lose weight and improve health. Sixty participants will receive care from the clinic and be followed for 12 months. Researchers will measure weight loss, body mass index, and fat distributi…

This study is testing whether an AI-driven system called SMART-CHD can improve outcomes for adults aged 18-45 with premature coronary artery disease. Participants will use a mobile app and wearable sensors to track their health and receive personalized guidance. The goal is to se…

This study is tracking 2,000 heart disease patients who receive the VIVO ISAR stent, a drug-coated device that releases medication to keep arteries open. Participants will take blood thinners for three months or less after the procedure. Researchers are monitoring for heart attac…

This early study tests a new vibrating guidewire designed to open completely blocked heart arteries (chronic total occlusions) in people with chronic chest pain that hasn't improved with standard treatments. The wire vibrates at its tip to help cross the blockage during a procedu…

This study tests whether taking spirulina (a microalgae) or seaweed (Gelidium corneum) supplements for 20 weeks can improve markers of heart health and change gut bacteria in people at high risk for heart disease. The trial includes 150 adults aged 50 or older with conditions lik…

This study tests a temporary heart pump called iVAC 2L in 100 patients undergoing high-risk angioplasty. The pump helps stabilize blood flow during the procedure. Researchers will track deaths, heart attacks, strokes, and other complications for up to a year to see if the device …

This study is testing new, lower-radiation CT scan methods for taking pictures of the heart and blood vessels. Researchers want to see if these scans are accurate at finding blocked arteries and predicting future heart problems like heart attacks. About 5,000 adults who need a he…

This study is testing whether a new type of CT scan, called photon-counting CT, can do it all in one go for people who have had a coronary stent placed. The scan aims to check the stent and arteries, measure blood flow to the heart muscle, and assess heart function in a single ex…

This study is testing a cloud-based artificial intelligence platform called Willem that analyzes ECG recordings to detect heart rhythm problems and abnormal patterns. Researchers will compare the AI's readings to those of board-certified cardiologists in over 5,300 high-risk card…

This study aims to create a non-invasive diagnostic algorithm using PET imaging and CT scans to identify microvascular angina in patients who have chest pain and signs of ischemia but no blocked coronary arteries. About 70 participants with symptoms of angina or shortness of brea…

This trial investigates whether an ultrasound of the neck arteries can provide similar information to a CT scan of the heart for diagnosing blocked arteries in people with chest pain. Currently, CT scans are used but involve a small amount of radiation. The study will compare the…

This study tests whether a magnetocardiography (MCG) device can detect reduced blood flow to the heart muscle in people with acute chest pain but no major artery blockages. About 3,786 participants will undergo MCG scanning, and results will be compared to a standard ultrasound t…

This study is testing whether artificial intelligence (AI) can predict or rule out a heart attack using data from standard blood tests. Researchers will analyze white blood cell properties from over 3,000 adults who come to the hospital with chest pain. The goal is to see if AI c…

This study is testing whether a thin wire that measures blood flow in heart arteries can help doctors decide which blockages truly need a stent. About 107 people with severe-looking blockages will have the wire test before and after stent placement. The goal is to see if some blo…

This study compares two types of CT scans—PET/CT and ultra-high-resolution CT—to see which one better detects early signs of coronary artery disease in people with symptoms like chest pain. Researchers will measure the amount of plaque in the arteries and check how accurately eac…

This study is testing whether a computer program (machine learning) can help doctors diagnose severe heart attacks in patients who have a heart condition called left bundle branch block (LBBB). LBBB can hide the usual signs of a heart attack on an ECG, making it hard to tell if a…

This study tests whether a new software-based method called Angio-IMR can diagnose coronary microvascular disease (blockages in tiny heart arteries) as accurately as the current standard test that uses a pressure wire inside the artery. About 192 adults with stable chest pain or …

This study looks at whether a special CT scan (FFR CT) can accurately measure blood flow in the heart's arteries compared to the standard invasive test. Researchers will review data from 500 patients with suspected coronary artery disease. If FFR CT proves accurate, it could redu…

This study looks at whether giving a nitrate drug during a heart test can better detect blood flow problems in people who have chest pain but no blocked arteries. About 50 adults will get the standard test, then a repeat test after nitrates. The goal is to see if nitrates improve…

This pilot study is testing whether advanced CT and MRI scans can diagnose coronary microvascular disease (CMD) without needing an invasive angiogram. CMD affects the heart's tiny blood vessels and causes chest pain in many people with no major artery blockages. Researchers will …

This study tests a new computer program that helps doctors diagnose blocked heart arteries more accurately using CT scans. The software combines several checks into one step, which may reduce the need for invasive procedures like heart catheterization. Researchers will look at pa…

This study aims to improve how doctors diagnose a rare heart condition where a coronary artery starts in the wrong place (AAOCA), which can cause sudden cardiac death in young athletes. Researchers will use artificial intelligence and 3D computer models to analyze CT scans and pr…

This study tests whether a new ultra-high resolution CT scanner is better than a standard CT at finding blocked arteries in the heart. About 140 adults with suspected coronary heart disease will get one scan, and the images will be compared to the usual method (catheterization). …

This study tests whether a non-invasive heart scan called magnetocardiography (MCG) can help doctors decide the best treatment for people with stable coronary artery disease. About 1,300 participants with moderate blockages will be randomly assigned to either MCG-guided care or s…

This registry study is testing a new AI tool called Heartflow PCI Navigator that creates a 3D model of a patient's heart arteries. Doctors use it to plan where to place stents to open blocked arteries. The study will enroll 5,000 people with coronary artery disease who are schedu…

This study is testing a special vest called HALD that records heart and lung sounds. Researchers want to see if the recordings are as accurate as what a doctor hears with a stethoscope. About 200 adults with or without heart or lung conditions will wear the vest during a clinic v…

This study tests a new technology called IVUS-FFR that uses ultrasound images from inside heart arteries to quickly check if a blockage is serious enough to need a stent. Unlike the current standard test, it doesn't require an extra pressure wire or medication that can cause disc…

This phase 3 trial tests whether an injection called XTR004, used with a PET scan, can accurately detect blood flow-blocking narrowings in heart arteries. About 395 adults with known or suspected stable coronary artery disease will receive the injection and undergo imaging. The r…

This study is testing a new type of MRI, called hyperpolarized 13C MRI, to see if it can better identify which patients with heart disease will benefit from bypass surgery. The technique measures how the heart produces energy by tracking two simple molecules. Researchers will com…

This study tests whether artificial intelligence can detect early signs of coronary artery disease from standard chest CT scans that don't use contrast dye. Researchers will analyze scans from about 1,600 adults to see if the AI can identify dangerous plaque and blockages. If suc…

This study tests a new MRI technique that uses a special iron-based contrast agent (ferumoxytol) to detect calcium buildup in heart arteries. Researchers will compare this method to standard CT scans in 100 adults with known calcified arteries. The goal is to see if the MRI can a…

This study tests a new imaging method called µQFR to see how well it can detect blocked blood flow in small side branches after a heart stent is placed. About 290 adults with coronary artery disease will be enrolled. The goal is to see if this non-invasive approach can replace mo…

This study tests whether artificial intelligence and special ECG monitoring can improve diagnosis of angina in people whose arteries are not blocked. Researchers will use a Holter monitor at home and an internal ECG during a procedure to detect subtle signs of heart muscle strain…

This study tests a new imaging tool called 3DStent that creates a 3D picture of stents placed in heart arteries. The goal is to see if it can detect when a stent is not fully expanded, which can cause problems. About 200 patients getting a stent will have both the 3DStent scan an…

This study tests whether an artificial intelligence (AI) algorithm can screen for coronary artery disease (CAD) by analyzing facial images. Researchers will enroll 1,392 high-risk adults (those with diabetes, high blood pressure, or over 65) and use the AI to classify them as hig…

This study compares two non-invasive tests for coronary heart disease: a CT scan of the heart arteries versus a stress ultrasound that also checks the neck arteries. The goal is to see which test better detects blockages and prevents heart attacks or other problems. 2,000 adults …

This study compares two ways to check heart arteries after a CT scan shows non-severe blockages: an invasive angiogram (a tube in the artery) versus standard non-invasive tests (like stress tests). About 2,000 people with chest pain or related symptoms will be randomly assigned t…

This study tests whether artificial intelligence can accurately detect coronary artery disease from ultrasound videos. Researchers will enroll 1500 people with suspected heart disease who are already scheduled for a coronary angiogram. The goal is to develop a faster, non-invasiv…

This study tests whether giving fish oil through a vein during heart surgery can prevent a common complication called atrial fibrillation (irregular heartbeat) and help patients recover faster. About 550 high-risk adults having elective heart surgery will receive either fish oil …

This study tests whether giving insulin or dexmedetomidine as a nasal spray before surgery can prevent early confusion and memory problems after coronary artery bypass grafting. The trial will enroll 150 adults aged 60 and older. Participants will receive one of the two nasal spr…

This study tests if fexuprazan can prevent upper stomach bleeding in 400 heart patients at high risk for bleeding who must take two blood thinners after getting a heart stent. Participants receive either fexuprazan or the standard drug lansoprazole daily for 6 months. The goal is…

This early-phase study tests whether placing amiodarone directly into the sac around the heart during open-chest surgery can prevent a common and serious irregular heartbeat called atrial fibrillation. About 63 adults aged 20-85 having bypass or valve surgery will receive this tr…

This study tests whether using a lung water monitor to tailor fluid intake can prevent acute kidney injury in elderly patients with kidney disease who are undergoing coronary angiography. 320 participants will receive hydration rates adjusted based on their lung water levels. The…

This study looks at whether a tailored prevention plan can stop coronary artery disease (CAD) in people who had cancer treatment more than 5 years ago. About 748 survivors aged 40-70 will get heart risk checks and, if needed, a CT scan to guide prevention. The goal is to catch an…

This study compares two types of nerve blocks (ESPB and SPSIPB) to see which provides better pain relief after coronary artery bypass surgery. About 64 adults aged 45-85 will receive one of the blocks before surgery, and their pain levels, opioid use, and recovery speed will be t…

This study tests if a new flexible cable (SuperCable) is better than standard steel wire for closing the breastbone after heart surgery. About 86 adults will be randomly assigned to one method. The goal is to see if SuperCable leads to faster bone healing, less pain, and shorter …

This study tests two different nerve blocks to see which one better controls pain after open-heart surgery. 90 adults aged 40-60 having coronary bypass will get one of the blocks or a sham procedure. The goal is to reduce pain and the need for extra painkillers, helping patients …

This study looks at whether singing—alone or in a group—can improve heart health in older adults with coronary artery disease. Researchers will test if people stick with the program and if it's practical to run a larger trial. The study involves 32 participants who will sing thre…

This study tests whether combining progressive muscle relaxation and guided imagery can lower stress, anxiety, and depression in people with stable coronary artery disease. Forty adults will be split into two groups: one gets eight sessions of these mind-body techniques over four…

This study tests whether myofascial release, a gentle hands-on therapy, can help people recover after heart surgery that splits the breastbone. Fifty adults with heart disease will receive either standard physical therapy or standard therapy plus seven daily sessions of myofascia…

This study compares two breathing techniques—segmental breathing and active cycle breathing—against standard care for people recovering from open heart surgery. Researchers want to see which method best improves oxygen levels, breathing rate, and shortness of breath. The trial wi…

This study tests whether giving a set of nerve blocks (injections of numbing medicine) right after anesthesia but before surgery can reduce pain and the need for opioid painkillers after coronary artery bypass grafting. 56 adults scheduled for elective bypass surgery will be rand…

This study looks at whether placing stents in blocked heart arteries can improve quality of life for people with heart failure with preserved ejection fraction (HFpEF), a condition where the heart muscle is stiff. About 350 participants will be randomly assigned to receive either…

This study tests whether keeping a special chest tube in place for up to 3 days after heart surgery can lower the chance of developing a fast, irregular heartbeat called atrial fibrillation. About 624 adults having routine heart surgery will be randomly assigned to get the tube p…

This study tests a gentle breathing method called thoraco-abdominal rebalance (TAR) in 26 adults who recently had heart bypass surgery. The goal is to see if TAR improves diaphragm movement and reduces breathing discomfort compared to standard physical therapy. Participants will …

This study tests a 3-month mobile health cardiac rehab program for people with INOCA (chest pain or ischemia without blocked arteries). Participants use an activity tracker, log exercise, and get weekly coaching. The goal is to see if this approach improves symptoms, daily functi…

This study tests whether a brain-training technique called neurofeedback can help people with both heart disease and anxiety control their heart rate during stress. 56 adults will either receive real or fake (sham) neurofeedback while their brain activity and heart rate are measu…

This study tests whether a non-invasive brain-training technique called neurofeedback can help people with both coronary heart disease and anxiety. Participants will learn to control a part of their brain linked to stress, using real-time feedback from a headband. The goal is to …

This study compares two common types of heart medications—beta-blockers and calcium channel blockers—in adults aged 65 and older who have stable angina (chest pain) and at least two other chronic conditions. The goal is to see which drug works better and is easier to tolerate, fo…

This study tests whether watching a short educational video before a planned heart procedure (called PCI) can help lower anxiety. About 144 adults will take part, with some watching the video and others receiving usual care. Anxiety levels are measured before and after using a st…

This study tests whether giving morphine during coronary artery bypass surgery can improve pain control and reduce side effects like nausea after the operation. Sixty adults scheduled for elective heart surgery will be randomly assigned to receive either morphine or no additional…

This study looks at two different virtual exercise programs for women with coronary heart disease. Over 12 weeks, participants will exercise twice a week either with high-intensity intervals or moderate continuous activity. The goal is to see which type better improves exercise c…

This study tests whether giving a numbing medicine (ropivacaine) through chest tubes after heart surgery helps patients recover better than a placebo. About 116 adults having planned heart surgery will take part. The goal is to see if this approach reduces pain and improves overa…

This study tests a new pain medicine called tafalgin against morphine in 100 adults recovering from coronary artery bypass grafting (CABG). Participants receive either a single shot of morphine or tafalgin when their pain level is high. The goal is to see if tafalgin controls pai…

This study tests a simple tool called iHeart DepCare to help people with heart disease who also feel depressed. About 200 adults will either get usual care or extra support and guidance to start depression treatment. The goal is to see if the tool helps more patients get the ment…

This study tests whether combining virtual reality with pleasant smells can lower pain and anxiety in people recovering from heart or lung surgery. About 80 adults scheduled for cardiothoracic surgery will either receive the VR-and-scent therapy or standard care. The goal is to s…

This study tests whether a nerve block called the serratus posterior superior intercostal plane block can reduce pain and the need for strong painkillers after minimally invasive heart surgery. Sixty adults will be randomly assigned to receive either the nerve block plus standard…

This study tests whether a specific nerve block, called the serratus posterior superior intercostal plane block, can reduce pain and opioid use after minimally invasive heart bypass surgery. Sixty adults undergoing this surgery will be randomly assigned to receive either the nerv…

This study will observe 60 adults having heart bypass surgery to see if a higher dose of the anesthetic propofol reduces nausea and vomiting after the operation. Researchers will compare patients who get high-dose propofol to those who get a low dose. Participants will be checked…

This study tests whether adding virtual reality (VR) nature scenes to exercise training helps people who had heart bypass surgery breathe easier and feel better. 66 adults with low heart function and ongoing shortness of breath will be split into three groups: one does circuit tr…

This study tests whether a single infusion of a patient's own bone marrow stem cells can reduce chest pain and improve quality of life for people with refractory angina—a severe form of chest pain that doesn't respond to standard treatments. About 110 participants will be randoml…

This study tests whether music therapy delivered by the BeatMove device can help people with leg artery disease walk farther during a 3-month outpatient walking program. Fifty-four participants will either get real music therapy or a sham version while doing 36 walking sessions. …

This study is testing a new type of MRI scanner that uses less energy than standard machines. The goal is to see if it can still take clear pictures of the heart, which could help people with metal devices in their body. Healthy volunteers and people with heart disease will have …

This study looks at how certain white blood cells, called monocytes, react to injury from a heart attack or ischemic stroke. Researchers want to learn how these cells sense danger signals and produce substances that might help heart muscle and brain tissue heal. The study involve…

This study looks back at the medical records of 1,000 people with coronary artery aneurysms—bulges in the heart's blood vessels. Researchers want to understand how these aneurysms change over time, what factors increase the risk of progression, and whether different treatment str…

This study tracks 500 adults with stable coronary artery disease or unstable angina who are undergoing a heart procedure called percutaneous coronary intervention (PCI) using a drug-coated balloon. Researchers are looking at how procedural details—specifically how long the balloo…

This study looks at whether a special CT scan (CT-FFR) can help doctors predict heart attacks and other serious events in people with chronic coronary syndrome. About 3,000 participants in China will be followed for up to 5 years. The goal is to see if abnormal CT-FFR results are…

This study is creating a decision aid for people with a rare heart condition called right anomalous aortic origin of a coronary artery (R-AAOCA). The condition raises the risk of sudden cardiac death, but the best management—surgery or careful observation—isn't clear. The aid wil…

This study is an early-stage trial to check the safety of a new drug called RO7763505. It involves 196 participants, first in healthy volunteers and then in people with stable coronary artery disease. The main goal is to see if the drug is safe and how the body processes it, not …

This study looks at whether advanced imaging can detect a hidden heart condition called cardiac amyloidosis in people with severe aortic valve stenosis. The condition can complicate treatment and recovery. Researchers will use echocardiography, CT, and SPECT/CT scans to check for…

This study will compare two types of heart-lung machines used during coronary bypass surgery to see how they affect blood flow to the brain. Researchers will measure brain pressure using an eye ultrasound and brain oxygen levels with a forehead sensor in 70 patients. The goal is …

This study is collecting blood samples and health data from 15,000 symptom-free adults over 40 to understand what healthy aging looks like at the molecular level. By tracking participants over time, researchers hope to establish normal ranges for thousands of blood markers and id…

This study aims to develop and test new MRI methods for imaging the heart and blood vessels to improve diagnosis and management of heart disease. It will enroll up to 3,400 adults, including both patients with heart conditions and healthy volunteers. Participants will undergo MRI…

This study examines whether a structured cardiac rehabilitation program — including exercise, education, and lifestyle changes — can influence ferroptosis, a form of regulated cell death, in people with coronary artery disease. Researchers will compare gene expression and blood m…

This study tracks over 16,000 teens and adults with severe asthma to see if the drug tezepelumab raises the risk of serious heart problems like heart attack, stroke, or heart-related death. Researchers will compare those taking tezepelumab to those on standard asthma treatments. …

This study investigates whether testicular cancer survivors who received cisplatin-based chemotherapy and bone marrow transplant have hidden heart disease that standard checkups might miss. Researchers will use advanced blood tests and CT scans to measure cholesterol, plaque in t…

This study tests whether a machine learning model can predict the outcome of a common heart procedure — placing a stent to open a hardened, calcified artery. Researchers will measure blood flow and pressure before and after the procedure in 100 adults with coronary artery disease…

This study will observe 500 adults with stable or acute heart artery disease who receive a laser treatment called Excimer Laser Coronary Atherectomy (ELCA) during a standard procedure to open blocked arteries. The goal is to track how well the laser works and how safe it is by re…

This study examines whether the duration a patient spends on cardiopulmonary bypass (heart-lung machine) and with the aorta clamped during coronary artery bypass surgery is linked to how long they stay in the intensive care unit afterward. Researchers will review medical records …

This study follows 100 people who had heart bypass surgery guided by a special CT scan, to see if imaging details and a blood fat called Lp(a) can predict how well they do afterward. Researchers will track symptoms, quality of life, and major heart events like heart attacks or st…

This observational study will follow 2,352 adults with coronary heart disease to see how factors like blood sugar, sleep, and heart imaging relate to thinking and memory problems. Participants will take memory tests and undergo scans and blood work during a hospital stay. The goa…

This study compares how much radiation doctors are exposed to during heart procedures (PCI) when using the left distal wrist versus the right wrist for artery access. About 748 patients scheduled for PCI will take part. The goal is to see if the left wrist approach reduces radiat…

This study tracks 98 people with peripheral artery disease who had a stent placed in their iliac artery. Researchers want to see which patients later develop serious limb complications, like needing another procedure or amputation. They will also check if frailty plays a role. Th…

This study tests two improvements for heart catheterization done through a small artery in the wrist. First, it checks if a special patch can stop bleeding faster. Second, it sees if using ultrasound to guide the needle makes the procedure more successful. About 480 adults needin…

This study looks at 60 people with stable angina who have two blocked heart arteries. During a procedure, doctors will temporarily inflate a tiny balloon inside each stent to reduce blood flow while the patient exercises on a bike. The goal is to measure exactly how much flow red…

This study is creating a large database of information from 10,000 adults undergoing heart surgery. Researchers will collect detailed data before, during, and after surgery to identify factors that affect recovery and complications. The goal is to improve risk prediction, persona…

This study follows 300 adults aged 30–60 with genetically confirmed familial hypercholesterolemia, a condition causing very high cholesterol. Researchers use CT scans to see how coronary artery plaques change over 5 years. The goal is to better understand disease progression and …

This study is observing 20,000 people undergoing routine heart or blood vessel procedures through the wrist (radial or ulnar artery). Researchers will track complications like artery blockage, spasm, and bleeding. The goal is to gather real-world data to improve safety and succes…

This study looks at whether a special imaging technique called Quantitative Flow Reserve (QFR) can help predict how well a blood vessel graft will work after coronary artery bypass surgery. Researchers will follow 110 patients for one year after surgery to check if the grafts sta…

This registry is following 5,000 adults with coronary artery disease who received a drug-coated balloon during a procedure to open blocked heart arteries. Researchers are tracking how often the treated artery fails, heart attacks, repeat procedures, and bleeding over the long ter…

This study looks at 300 people with rapid atrial fibrillation (a fast, irregular heartbeat) to understand why some have heart damage. Researchers will use blood tests and heart scans to see if blocked arteries are the cause. The goal is to improve how doctors diagnose and manage …

This study is collecting medical information and blood/urine samples from 9,500 people with various heart and blood vessel conditions, plus healthy volunteers, over 20 years. The goal is to find better ways to diagnose heart disease and predict how patients will do in the future.…

This study will enroll 246 people who have had a heart stent but still experience chest pain. Researchers will use a detailed diagnostic approach during a heart catheterization to identify whether the pain is due to new blockages, incomplete treatment, or other issues. The goal i…

This study looks at whether a special nursing care model helps people with long-term health conditions like diabetes, heart disease, or Parkinson's work better with their advanced practice nurse. About 420 adults will take part. The goal is to see if this approach improves how pa…

This study compares two solutions used to protect the heart during coronary artery bypass surgery: standard blood cardioplegia and del Nido cardioplegia. Researchers will use MRI scans to see which solution better preserves heart muscle. The trial involves 60 adults with multives…

This study looks for micro- and nanoplastics in the blood of the heart's arteries in 120 people with chronic coronary syndrome. Participants will have a standard heart CT and an angiogram, and a small blood sample from the heart will be tested for plastic particles. The goal is t…

This study follows 200 people having beating heart bypass surgery to see how well Getinge's devices perform and if they cause any problems. The devices help stabilize the heart and improve visibility during surgery. No extra tests or visits are needed—just information from the ho…

This study aims to develop artificial intelligence tools that can analyze heart CT scans to identify dangerous plaque buildup that may lead to heart attacks. Researchers will study 4,000 people with known or suspected coronary artery disease to create and test a computer model th…

This study gives low-dose interleukin-2 to people who have had a heart attack and are scheduled for bypass surgery. Researchers want to see how the drug affects certain immune cells (regulatory T cells) inside heart tissue compared to blood. The goal is to understand whether thes…

This pilot study tests whether having patients with coronary artery disease fill out online surveys about their symptoms and quality of life, and sharing the results with their doctors, is practical and helpful. About 200 patients and their cardiologists will take part. The goal …

This study looks at immune cells called macrophages in the arteries of people with heart disease or poor leg circulation. Researchers will use imaging and blood tests to see how these cells are activated. The goal is to better understand the disease, not to test a new treatment. …

This study examines how frailty and other health factors affect the short- and long-term outlook for people aged 75 and older who are hospitalized for a heart attack or unstable angina. Researchers will compare two treatment approaches—a procedure to open blocked arteries versus …

This study follows 1,500 people who are scheduled for heart surgery or a less invasive valve procedure. Researchers want to learn what factors predict major heart problems later, like heart failure or stroke. No new treatment is being tested—the goal is to gather information to i…

Many people with chronic kidney disease also have heart disease, but heart procedures like angiograms and surgery can raise the risk of kidney complications. This study tests an online decision aid called 'My Heart and CKD' that helps patients and doctors weigh the benefits and r…

This observational study looks at how lowering body temperature during heart-lung bypass surgery affects two common brain monitors (BIS and PSI). Researchers will track 60 adults undergoing planned coronary bypass surgery. The goal is to see if the monitors' readings change diffe…

This observational study will enroll 10,000 adults who are already scheduled for a cardiac CT scan. Researchers will use artificial intelligence to analyze the scans, looking for subtle signs of dangerous plaque that might predict future heart attacks. Participants will also give…

This study looks at 150 adults who had a heart attack but whose main heart arteries were not blocked. Researchers will use special imaging and pressure tests to check for problems in the tiny blood vessels of the heart. The goal is to see if these microvascular issues lead to wor…

This study is a registry that will enroll 816 adults with coronary artery disease. It compares two types of heart scans—CCTA and OCT—to see which one better identifies dangerous plaque and helps doctors plan treatment. The goal is to improve diagnosis and long-term outcomes, not …

This study tests whether a heart ultrasound measurement called the superior vena cava collapsibility index (SVC-CI) can predict how patients will respond to fluids during coronary artery bypass surgery. Researchers will tilt the operating table (head up then head down) to mimic g…

This study looks at whether gum disease is more common in people who have had a heart attack. Researchers will compare the gum health of 320 adults—some who recently had a heart attack and some who haven't—to see if there's a link. The goal is to gather information that could lea…

This study looks at two ways to check for blocked heart arteries in people with severe aortic stenosis who are getting a new heart valve (TAVI). One method is the usual invasive X-ray test; the other uses non-invasive risk management. The goal is to see which approach leads to be…

This study is testing a drug called regadenoson in children who need a special heart MRI. The drug helps doctors see how well blood flows to the heart during a stress test. Researchers want to find the right dose and make sure it is safe for kids of different ages, from infants t…

This registry is following 2,000 people with chronic coronary artery disease who are taking long-term blood thinners (antiplatelet or anticoagulant drugs). The goal is to track how often serious bleeding or clotting events (like heart attacks or strokes) occur. By understanding t…

This registry is tracking 2,000 people with atrial fibrillation who are taking blood thinners for a long time. The goal is to see how often serious bleeding or clotting events happen. Researchers will also look at genetic factors that might affect risk. This is an observational s…

This study looks at whether giving less fluid during heart surgery, a technique to reduce blood loss, increases the risk of kidney injury. Researchers will measure kidney injury markers in 100 adults having elective bypass surgery. The goal is to understand if this common practic…

This study is testing a tool called Transit-Time Flow Measurement (TTFM) that uses sound waves during heart bypass surgery to check blood flow through the new blood vessels. The goal is to see if using this tool helps the grafts stay open longer. About 1242 adults having their fi…

This study uses advanced total-body PET scans to look inside vein grafts after coronary artery bypass surgery. Researchers want to understand why some grafts fail, leading to heart attacks or strokes. They will scan 70 patients—some soon after surgery and others years later—to tr…

This study reviews the long-term heart health of 1,500 patients who received a drug-eluting balloon to treat coronary artery disease between 2010 and 2025. Researchers will track major heart events like heart attacks, strokes, and repeat procedures. The goal is to better understa…

This study looks at whether filtering out blue light at night in hospital rooms can reduce inflammation, protect thinking skills, and improve mood and sleep in 80 adults having elective heart surgery. Participants will be randomly assigned to wear blue-blocking glasses or regular…

This study looks at how aging inside our cells might make heart arteries more prone to dangerous plaques. Researchers will measure DNA damage and other aging markers in 300 adults with different types of chest pain or heart attacks. The goal is to find better ways to predict who …

This study involves over 12,000 Chinese patients with coronary heart disease who take blood thinners. The goal is to find new biological markers that can better predict who is at risk for dangerous blood clots or major bleeding. Researchers will combine genetic, protein, and imag…

This study looks at people who have chest pain but no major blockages in their heart arteries. Researchers will test if giving medication based on the specific type of tiny blood vessel problem (endotype) works better than standard care. About 180 participants will be followed fo…

This study looks at people with chest pain (angina) but no major blockages in their heart arteries. During a standard angiogram, doctors will perform an extra diagnostic test to see if it helps guide treatment. Half the participants will have the test results shared with their do…

This study tests a new device that collects blood samples directly from heart arteries in 300 people with coronary artery disease. Researchers will analyze these samples to find biomarkers that could help develop personalized treatments. The goal is to better understand the disea…

This study tests whether a new anesthesia method for heart bypass surgery is better for patients and the planet. About 116 adults having planned bypass surgery will receive either the new technique (which uses fewer drugs and a nerve block) or standard anesthesia. Researchers wil…

This study is enrolling 1,200 people with coronary artery disease who are starting cardiac rehab. Researchers will collect detailed health data, including fitness tests, activity tracker steps, and long-term heart monitoring, to train artificial intelligence models. The goal is t…

This observational study at Imperial College London will enroll 70 people undergoing heart catheterization to understand why some patients tolerate ventricular tachycardia (VT) better than others. Researchers will measure blood pressure and blood flow in the heart during simulate…

This study follows 80 adults who had coronary bypass surgery to see how developing pneumonia in the hospital affects their heart and lung health over the next year. Researchers will compare patients who get pneumonia with those who don't, using blood tests, heart and lung functio…

This study looks at whether telling people their genetic risk for coronary artery disease helps them lower cholesterol and improve heart health over one year. Researchers will enroll 500 adults aged 30-75 who are not on cholesterol medication. Half will get their genetic risk sco…

This study follows about 20,000 people with coronary artery disease who had a special test called FFR to guide their artery-opening procedure. Researchers want to see how these patients' heart health changes over 2 years. The goal is to better understand the long-term results of …

This study is observing 10,000 people with severe narrowing in the left main coronary artery, a critical heart vessel. Researchers are comparing the long-term results of three approaches: medication, stenting with drug-coated stents, and bypass surgery. The goal is to see which w…

This study follows 160 heart failure patients who are scheduled for coronary artery bypass surgery. Researchers want to see if measuring a substance called GDF-15 in the blood before surgery can help predict who will have serious heart problems in the next year. The study does no…

This study is testing new heart MRI techniques to see how the heart adapts to stress, like exercise or fluid changes. Researchers will study 135 healthy volunteers and people with heart conditions. The goal is to improve understanding of heart function and develop better diagnost…

This study is re-examining 1,400 adults in Stockholm to find early signs and risk factors for heart, lung, and liver diseases. Participants will get advanced scans, blood tests, and questionnaires. The goal is to better understand how these diseases develop and how to predict the…

This study follows 30,000 adults with coronary artery disease to see how different risk factors affect their long-term survival. Researchers will track deaths from any cause and from heart problems specifically. The goal is to better understand what influences outcomes in real-wo…

This study looks at whether an 8-week stress reduction program can lower inflammation in the arteries of people with stable heart disease. About 36 adults who feel stressed will take part. Researchers will use special PET/MRI scans to measure changes in artery and brain activity …

This study follows 2000 adults with suspected heart artery disease who undergo special imaging and pressure measurements during a heart catheterization. Researchers want to see which test results best predict future heart problems like heart attacks or the need for another proced…

This study looks at 54 adults with coronary artery disease to see which of four treadmill tests best measures how much oxygen their bodies use during exercise. Researchers want to know if the best test differs between women and men. The goal is to improve exercise testing for peo…

This study is observing ICU heart patients who have a femoral artery sheath removed after procedures like cardiac catheterization. Researchers want to find out what factors affect how long it takes for bleeding to stop and how long patients must lie flat. The goal is to create a …

This study uses magnetic resonance spectroscopy, a special MRI technique, to measure the heart's energy levels without needles or biopsies. Researchers will compare healthy volunteers, people with heart failure, and those with other heart conditions to see if low energy metabolis…

This study is measuring a thin layer inside blood vessels called the glycocalyx in 35 adults with coronary heart disease before and after bypass surgery. Researchers want to understand how this layer and oxidative stress affect blood vessel function. The goal is to find new marke…

This study will have up to 10,000 adults wear a smartwatch for one year to collect health data like heart rate and activity. Participants will also answer questions through a phone app. The goal is to see if smartwatch data can help doctors spot heart problems earlier. No drugs o…

This study is looking at 200 people having planned heart bypass surgery to see if their blood sugar levels (HbA1c) before surgery can help predict if they will develop acute kidney injury afterward. Researchers will also use ultrasound to measure kidney blood flow. The goal is to…

This study is observing 1,500 people with coronary artery disease to find better ways to predict who is at risk of sudden cardiac arrest. Researchers are looking at genetic, electrical, and biological markers, as well as psychological factors. The goal is to identify high-risk pa…

This study follows 100 men aged 30-75 who had a heart procedure called PCI (stent placement) to open blocked arteries. Researchers want to see how erectile function changes over 6 months, comparing those who had a heart attack to those with stable chest pain. Participants fill ou…

This study is testing a new type of MRI scan that looks at how the heart uses energy. It involves 15 people: 6 healthy volunteers and 9 patients with severe heart disease who are scheduled for bypass surgery. The goal is to see if this new scan can better measure heart muscle hea…

This study is for adults having planned heart bypass surgery. It tests a technique where leftover blood from the heart-lung machine is returned to the patient right after surgery. The goal is to see if this reduces the need for blood transfusions in the first 24 hours. Researcher…

This study aims to improve how doctors interpret stress echocardiograms—ultrasounds of the heart during exercise—by using machine learning. Researchers will analyze data from 1,250 patients to develop more accurate tools for detecting blocked arteries and heart attack risk. The g…

This study is testing whether a simple brain ultrasound, called transcranial Doppler, can predict confusion or memory loss after heart bypass surgery. Researchers will measure blood flow in the brain during surgery and check patients for delirium and cognitive changes afterward. …

This study looks at a new, drug-free method to measure blood flow after opening blocked heart arteries in people with multiple blockages. About 150 adults will get a standard pressure wire test plus a newer technique using contrast dye and nitroglycerin. The goal is to see if the…

This study will use a special camera (NIRS-OCT) to look inside the heart arteries of 1,516 people with diabetes. The goal is to find fatty plaques that might rupture and cause heart attacks. Researchers hope to create a new way to identify these dangerous plaques early, so doctor…

This study is testing a new way to measure blood flow in the heart's arteries using ultrasound, without needing special wires or drugs. Researchers will follow about 500 people with coronary artery disease for one year to see if this measurement can predict serious heart events l…

This study is testing whether a special CT scan of the heart (CTCA) can better predict heart attacks and other heart problems in people waiting for a kidney transplant. About 332 patients on the transplant list will get a single CTCA scan before their surgery. Researchers will th…

This study is reviewing medical records from 5,000 heart and blood vessel surgery patients to find factors that influence recovery and survival. Researchers are looking at data from 2001 to 2013 to identify what leads to complications or death after surgery. The goal is to improv…

This study is looking at whether data from a Fitbit smartwatch (like heart rate, sleep, and steps) can help assess heart health and predict the risk of heart disease. Researchers will track 100 adults over time, comparing their wearable data with standard heart health measures. T…

This study looks at whether a special heart ultrasound measurement, called global longitudinal strain (GLS), can predict if a person will have trouble coming off the heart-lung machine during heart surgery. About 213 adults having planned heart surgery will have their hearts meas…

This study is for adults with a blocked radial artery who need a heart procedure like angiography or angioplasty. Doctors will use the ulnar artery in the same wrist instead. The goal is to see if this approach is safe and how it affects hand strength, feeling, and daily use. Res…

This study looks at why some people with coronary heart disease continue to have plaque buildup in their arteries even when they are on strong cholesterol-lowering medication. Researchers will follow 900 adults who have already had a heart procedure to see if leftover cholesterol…

This study tests whether doing several heart scans (blood flow, ultrasound, and CT) all in one day is faster and cheaper than the usual step-by-step approach for people with possible coronary artery disease. About 500 patients from Swedish primary care centers will be followed fo…

This study asks 600 people—heart disease patients and healthcare providers—to rate how serious different complications are, like heart attack or stroke, compared to death. The goal is to better understand if patients and doctors value these events differently. The results could h…

This study looks at what heart disease patients and their doctors prefer when choosing between two treatments: a permanent metal stent or a drug-coated balloon that dissolves over time. Researchers want to understand how much extra risk people are willing to accept to avoid havin…

This study is observing 165 adults with coronary artery disease who are getting a drug-coated balloon procedure. Researchers will use CT scans before and after the procedure to measure changes in blood flow and plaque buildup. The goal is to learn how the balloon affects the arte…

This study looks at how mental stress impacts the small blood vessels of the heart in postmenopausal women with coronary microvascular dysfunction (CMD). Researchers will measure heart activity, stress responses, and daily symptoms in 150 women using imaging, questionnaires, and …

This study is creating a large registry of people who have had a spontaneous coronary artery dissection (SCAD), a type of heart attack. Researchers will collect medical history and follow participants over time to learn more about risk factors, treatments, and long-term outcomes.…

This study is following 1,000 people who have had a severe type of heart attack called STEMI. Researchers are collecting detailed medical data to understand how different organs talk to each other during recovery. The goal is to find key signals that could lead to better treatmen…

This study looks at 200 people with a family history of heart disease but no symptoms. They will get a special CT scan and a blood test to find hidden, high-risk plaque in their arteries. The goal is to see if the scan can better predict who needs early treatment compared to stan…

This study looks at whether simple, non-invasive skin tests can detect early signs of heart disease by measuring how well small blood vessels work. Researchers will study 900 people aged 60-75, comparing skin blood flow measurements with detailed heart scans. The goal is to find …

This study tests whether a two-part approach—improving communication about viral infections and having pharmacists double-check prescription lengths—can reduce how many days antibiotics are prescribed for respiratory infections like bronchitis, sinusitis, and sore throat. About 4…

This study is testing a new way to predict if people with stable coronary artery disease will have a heart attack or heart injury during a planned stent procedure. Researchers will use a genetic score (ABCD-GENE) to sort 500 participants into high- or low-risk groups. The goal is…

This study will enroll 250 people with stable coronary artery disease to see how well a CT scan measures plaque buildup in heart arteries compared to an invasive ultrasound. Participants will undergo both tests as part of their standard care. The goal is to improve non-invasive d…

This study looks at whether root canal treatment can reduce inflammation markers linked to heart disease in people with stable coronary artery disease and infected tooth roots. Eighty adults will either get immediate root canal treatment or wait three months. Researchers will mea…

This study is looking at how well drug-coated balloons work for treating narrowed heart arteries. Researchers will follow 1,500 adults who get this treatment to see how they do in the short and long term. The goal is to gather more information on the success and safety of this ap…

This observational study will follow 1,000 patients in Poland who undergo a procedure to open completely blocked heart arteries. Researchers will collect data on success rates, complications, and long-term outcomes to understand what works best in everyday practice. The goal is t…

This study is a large registry that will collect health information from up to 60,000 people with both heart and kidney disease. The goal is to better understand how these conditions interact and to find ways to predict and improve patient outcomes. No new treatments or procedure…

This study looks at 1,300 people with coronary artery disease who have a high risk of bleeding after getting a heart stent. Researchers will use artificial intelligence to analyze which blood-thinning drugs and treatment lengths work best to prevent serious bleeding and heart att…

This study looks at 10,000 adults aged 45 or younger who have symptoms of heart disease. Researchers will use CT scans and health information to find patterns that predict how the disease gets worse over time. The goal is to create a tool that helps doctors identify young people …

This study follows 4000 people with coronary artery disease who have had special imaging of their heart arteries. Researchers will track them for 5 years to see how well the images predict serious events like heart attacks or the need for repeat procedures. The goal is to improve…

This registry is following 5,000 people who had a heart attack and were treated with medications, stents, or bypass surgery at Asan Medical Center in Korea. Researchers are tracking deaths, repeat heart attacks, and other major events over the long term to understand which treatm…

This study follows 25,000 people with multivessel coronary artery disease to see how different treatments—medication, surgery, or stents—affect long-term health. Researchers will track serious events like heart attacks, strokes, and death. The goal is to learn which approach work…

This study is tracking 500 patients who received rotational atherectomy, a procedure that uses a tiny rotating burr to grind away hardened plaque in heart arteries. Researchers want to see how safe and effective it is in real-world settings. The main goal is to measure how many p…

This study compares two methods for opening completely blocked heart arteries: antegrade dissection and re-entry (ADR) versus a retrograde approach. Researchers will measure procedure time, success rates, complications, and even doctor stress levels. 74 participants with difficul…

This large study in China will enroll 12,000 heart disease patients who have had or will have a stent procedure (PCI). Researchers will collect blood samples, imaging, and health data to train an artificial intelligence system. The goal is to predict which patients are likely to …

This study tests a non-invasive device that measures blood flow in the skin of people with severe leg artery disease. Researchers will compare results from 15 patients before and after a procedure to open blocked arteries, and also compare them to 15 healthy volunteers. The goal …

This trial tests whether using a wrist artery access point closer to the hand (distal radial) is safer than the usual wrist access for complex heart procedures like opening blocked arteries. About 708 adults with stable or unstable heart conditions will be randomly assigned to on…

This study looks at whether a follow-up CT scan of the heart's arteries (coronary CT angiography) one year after stent placement can reduce major heart problems like heart attacks or death compared to usual care. It will enroll 3,500 high-risk patients who have had stents placed …

This study will observe 5,000 adults in Taiwan who have a chronic total occlusion (CTO) — a complete, long-term blockage in a heart artery. Researchers will track how often procedures to open these blockages succeed and what complications occur. The goal is to learn which patient…

This study looks at how calcium deposits in artery walls affect the healing of a stent (a small mesh tube) placed to open blocked arteries. Researchers will use a special camera to compare stent healing over calcium spots versus healthy tissue in 40 patients with coronary artery …

This study looks at 1000 people with heart artery disease who already need a special camera (OCT) inside their arteries during a routine procedure. Researchers will use those detailed images and artificial intelligence to find patterns that might predict future heart problems, li…

This study looks at 570 people with chronic coronary syndrome (chest pain or shortness of breath due to narrowed heart arteries). Participants with abnormal blood flow on a PET scan will be randomly assigned to either immediate heart catheterization or a 3-month delay, while both…

This study looks at how different fluids used to fill the heart-lung machine before heart surgery affect the body's balance. 80 adults having bypass or valve surgery will be split into four groups, each receiving a different priming solution. Researchers will track changes in aci…

This study reviews medical records of 200 adults who came to the ER with a heart attack or unstable chest pain. It compares what happens when patients get two blood thinners (aspirin plus another) in the ER versus waiting to give the second one in the catheterization lab. The goa…

People with type 2 diabetes are at high risk for heart disease. This study will follow 1,000 such patients who have already had a heart CT scan. Researchers will repeat the scan and track how plaque buildup in the heart's arteries changes over time. The goal is to better understa…

This study looks at a fast-progressing type of coronary artery disease that may be driven by inflammation. Researchers will compare 20 patients with this condition to 10 patients with typical heart disease, using lab tests, imaging, and physical assessments. The goal is to better…

This study aims to learn more about heart disease that is linked to inflammation but does not progress quickly. Researchers will follow 120 adults with this condition to track their treatments and health outcomes, such as heart attacks or the need for procedures. The goal is to b…

This study is collecting information from 3,000 people who receive a special drug-coated balloon to open blocked heart arteries. The goal is to see how effective and safe the balloon is in real-world use, including for different types of blockages and patient conditions. Research…

This study looks at whether a cholesterol-lowering drug called Evolocumab can improve blood flow in the small blood vessels of the heart. About 50 people with stable coronary artery disease will get the drug for 12 months and have heart scans before and after. A small control gro…

This study will follow 80 people with advanced chronic kidney disease who are waiting for a kidney transplant. Researchers will use PET scans and echocardiograms to measure blood flow and heart function before and after transplant. The goal is to see if improving kidney function …

This study tests whether artificial intelligence can evaluate how well surgeons perform a key step in heart bypass surgery. Researchers will compare AI scores to those from human experts. The trial involves 284 patients undergoing bypass grafting and aims to see if AI can reliabl…

This study looks at 320 people who had a severe heart attack (STEMI) and have blockages in other arteries besides the one that caused the attack. Researchers will use CT scans and blood tests to see which blockages are likely to cause future problems. The goal is to find out if o…

This study will follow 10,000 people who come to a clinic in Davos, Switzerland for cardiac rehabilitation after a heart attack, surgery, or other heart problem. Researchers will collect health data, blood samples, and genetic information to understand what helps people recover b…