Coronary artery disorder

This study tests whether using a special tube (EZ-Blocker) to collapse one lung during heart bypass surgery can reduce fluid buildup and the need for chest drains. The trial includes adults having planned coronary artery bypass surgery that uses the internal thoracic artery. The …

This study looked at two ways to manage older patients (80+) who had a mild type of heart attack (NSTEMI). One group got routine angiography (an invasive look at the heart's arteries), while the other group first had a non-invasive imaging test (SPECT or stress echo) and only got…

This study tested whether personalizing blood-thinning drugs based on a patient's genetics and risk factors could reduce bleeding after a heart attack. It enrolled 39 patients who had already been on standard dual therapy for a year. The trial was terminated early, so the finding…

This study looked at whether long-term treatment with vitamin C+E and statins could reduce artery spasms and plaque buildup in people with variant angina, a type of chest pain. The trial planned to enroll 320 adults aged 30 and older, but it was terminated early. The main goal wa…

This study tested a drug called CardiolRx in 90 hospitalized COVID-19 patients who also had heart disease or risk factors like diabetes or high blood pressure. The goal was to see if the drug could lower the chance of death, needing intensive care, or having heart problems. The t…

This study looked at a hybrid approach for treating multiple blocked heart arteries: a minimally invasive bypass for the main artery plus stents for others. Only 6 people took part before the study was stopped early. The goal was to see if this combination is safe and effective i…

This study tested a device called Efferon LPS that filters blood during heart surgery when a heart-lung machine is used. The goal was to see if it could prevent multiple organ failure, especially kidney damage. Only 14 people took part before the study was stopped, so the results…

This study looked at how well the BIOFREEDOM stent works in everyday medical practice for people with narrowed heart arteries. Researchers planned to track 218 patients to see rates of death, heart attack, or need for repeat procedures. The study was stopped early, so results are…

This study tested a new type of stent (BiOSS LIM C) designed for blockages at the left main coronary artery fork. The trial enrolled 130 people with severe blockages. Unfortunately, the new stent did not work as well as the standard stent, and the study was stopped early.

This study tests new methods to measure pressure, blood flow, and blockage size in heart arteries. Researchers want to see if these measurements can better identify which blockages are serious enough to cause heart damage. The study involves people with known or suspected coronar…

This study looked at whether a special CT scan called FFR-CT can help emergency room doctors better diagnose coronary artery disease in patients with chest pain. The plan was to compare treatment decisions made with and without the FFR-CT results. However, the study was stopped e…

This study tested a new stress echocardiography method using regadenoson and atropine to diagnose coronary artery disease. It involved 45 adults scheduled for cardiac catheterization. The goal was to see if this faster, radiation-free approach could accurately detect significant …

This study looked at whether measuring the speed of pulse waves in arteries, combined with machine learning, could improve prediction of significant coronary artery disease in people with chest pain or shortness of breath. Researchers planned to enroll 156 patients undergoing a h…

This study compared a newer PET heart scan (using XTR004) with a standard SPECT scan to see which gives doctors more confidence in diagnosing borderline blocked arteries. It involved 17 adults with suspected stable heart disease and 30-90% blockages seen on a prior CT scan. The g…

This study tested whether taking roxadustat before heart bypass surgery could prevent sudden kidney damage, a common complication. The trial enrolled 98 adults aged 18-80 with planned bypass surgery. The drug aims to help tissues handle low oxygen better. However, the study was t…

This study tested whether adding a video to standard discharge education helps patients who have had coronary artery bypass graft (CABG) surgery feel more satisfied and less anxious. 120 patients were randomly assigned to receive either standard education, a standard video, or a …

This study looked at whether letting patients manage their own recovery precautions after heart surgery leads to a better quality of life compared to following standard sternal precautions. Ten adults who had heart surgery were followed for up to a year. Researchers checked pain,…

This study looked at whether measuring a natural clot-busting substance (t-PA) released from heart arteries could predict future heart attacks or death in people with mild to moderate coronary artery disease. Researchers gave a small dose of bradykinin into the heart artery durin…

This study looked at how the heart's pumping function recovers after a short, controlled blockage of a coronary artery using a balloon. Six adults with stable coronary artery disease undergoing angioplasty had a balloon inflated in their artery for 90 seconds. Researchers measure…

This study looked at how two common pain relievers—celecoxib (a Coxib) and naproxen (an NSAID)—affect blood clotting in people with rheumatoid arthritis who also have heart disease or are at high risk for it. All participants took low-dose aspirin daily. The goal was to see if on…

This study tested whether starting with a low-cost coronary calcium scan (about $100) could safely avoid the need for a more expensive heart stress test (over $1,500) in people with chest pain. Researchers planned to enroll 48 adults aged 50 and older with suspected heart disease…

This study looked at using a special wire that measures blood pressure inside heart arteries (called FFR) to help doctors decide which blockages to treat with stents. It included 438 people with two or more blockages in the same artery. The study was stopped early, so the results…

This study tested whether a 16-week program of yoga and lifestyle changes could affect gene activity (micro RNA) and heart disease risk factors in 16 adults with coronary artery disease. Participants had either undergone a heart procedure or had non-obstructive heart disease with…

This study tested whether fentanyl, a painkiller used during heart stent procedures, reduces the effectiveness of ticagrelor, a blood thinner given to prevent clots. Researchers compared crushed versus whole ticagrelor pills in 45 patients. The trial was stopped early, so results…