Coronary artery disorder

This study tests whether spermidine, a natural substance found in foods like soy and aged cheese, can improve heart and muscle health in elderly people with coronary artery disease. 180 participants aged 65 and older will receive either spermidine capsules or a placebo for a peri…

This study tests whether a web-based coaching program called CardioFit can help people with coronary artery disease become more physically active. Participants use a secure website to create personalized exercise plans with guidance from an online coach. The trial compares Cardio…

This study tests whether an automated phone system that calls smokers with coronary heart disease after hospital discharge can help them quit. Participants receive calls at several time points over six months, checking on their smoking and offering support. The goal is to see if …

This study explores whether combining a high-protein Mediterranean diet with resistance exercise can help people with heart disease build muscle and lower their risk of future heart problems. The trial enrolls adults who have completed cardiac rehab and may have low muscle mass w…

This study tests whether a three-month smartphone-supported walking program can improve daily step counts, psychological well-being, and body composition in adults with cardiovascular disease or type 2 diabetes. Participants use the Walk15 app to set personalized step goals and t…

This study tested a coaching program called MACRO-I for adults aged 70 and older who had a heart event. The program used coaches to guide patients through starting cardiac rehab, either at a center, at home, or a mix of both. 416 participants were split into the coaching group or…

This study tested whether using ultrasound inside the heart arteries (IVUS) to guide stent placement works better than standard X-ray guidance for people with a blockage in the left main coronary artery. About 800 patients were randomly assigned to one of the two methods and foll…

This study tested whether a drug-coated balloon can stabilize fatty plaques in heart arteries that are at risk of rupturing and causing a heart attack. Researchers treated 45 patients with a recent heart condition, using a special balloon to deliver medication directly to the pla…

This large study tested whether evolocumab (Repatha), a cholesterol-lowering injection, could reduce major cardiovascular events like heart attacks, strokes, or death in over 12,000 adults at high risk but without a prior heart attack or stroke. Participants received either evolo…

This trial tests whether a new 3D-imaging method called vFFR works as well as the standard pressure-wire technique (FFR) to guide treatment for narrowed heart arteries. About 2,200 adults with stable chest pain or a recent non-emergency heart attack will be randomly assigned to o…

This study tested whether sending personalized text messages about lifestyle changes could improve heart health in 700 people who had a stent placed for coronary artery disease. Half received 4 texts per week for 24 weeks, while the other half got standard care. Researchers measu…

This study tests whether motivational interviewing—a supportive, goal-oriented counseling approach—can help people who have had a heart stent adopt and maintain healthier habits. Participants receive one-on-one coaching sessions and reminder texts over three months, while researc…

This study tests a newly designed device to hold arterial pressure monitoring lines in place after coronary artery bypass surgery. The goal is to see if it keeps readings more accurate and stable than standard tape, especially when patients move. Sixty adults undergoing bypass su…

This study tested whether a team of specialists—an endocrinologist, diabetes educator, and dietician—could help people with type 2 diabetes and heart disease control their blood sugar better than standard care. 169 patients were split into two groups: one received usual care from…

This study tested a device called ShortCut that splits the leaflets of a failing artificial heart valve before placing a new valve inside it. The goal was to prevent the old leaflets from blocking the coronary arteries, which can cause a heart attack. Eight people at risk for thi…

This study tested whether breathing air with low and then high oxygen before heart bypass surgery could help protect the heart from damage. 120 adults scheduled for bypass surgery took part. The approach is drug-free and aims to reduce complications after surgery.

This study tested a surgical technique called femoral tripod eversion for people with blocked leg arteries. 37 patients were followed for two years to check safety and effectiveness. The procedure aims to clear blockages without using synthetic materials. Early results suggest it…

This study tested whether using a heart MRI to find scar tissue can help decide which people with mild-to-moderate heart failure should get a defibrillator (ICD) to prevent sudden cardiac death. About 449 adults with a weakened heart pump (ejection fraction 36-50%) and scar tissu…

This study tested whether a half-dose blood thinner (ticagrelor) taken alone after heart stent placement works as well as the standard two-drug therapy in East-Asian patients with chronic coronary syndrome. Sixty participants were randomly assigned to one of three treatment group…

This study tested whether ticagrelor, a newer antiplatelet drug, reduces heart muscle damage during a procedure called rotational atherectomy, which clears hardened arteries. 180 stable heart patients received either ticagrelor or standard clopidogrel before and after the procedu…

This study tested a new device called Firesorb, a temporary scaffold that slowly releases medicine to keep heart arteries open and then dissolves over time. Researchers compared it to a standard permanent stent in 430 people with coronary artery disease. The goal was to see if th…

This pilot study tested whether varenicline (Chantix) helps smokers with coronary heart disease quit better than the standard nicotine patch. Fifty motivated smokers who had a heart-related event were randomly assigned to one of the two treatments for 12 weeks. The main goal was …

This study tested a new drug called RBD4059 in 30 adults with stable coronary artery disease to see if it is safe. Participants received either the drug or a placebo and had 11-12 clinic visits over about a year. The main goal was to check for side effects and measure how the dru…

This study looked at 108 people whose heart stents had narrowed again after being placed. Doctors tested three different devices: two types of drug-coated balloons and one new stent. The goal was to see which one works best to keep the artery open and prevent future heart problem…

This study looked at whether using half the usual dose of heparin during heart surgery (bypass or valve replacement) could reduce bleeding afterward. Heparin is a blood thinner used to prevent clots during surgery, but it can increase bleeding. The study involved 238 adults and c…

This study tested whether eating yam gruel daily for 12 weeks could improve cholesterol levels in 72 people who had a heart stent placed. Participants either received standard care alone or standard care plus yam gruel as a partial dinner replacement. Researchers measured cholest…

This completed Phase 2 trial tested whether a single daily polypill (containing a statin, aspirin, and a blood thinner) could improve medication adherence in 140 patients who had a heart attack and received a stent. The study compared the polypill to usual care with separate pill…

This study tested two different methods of pacing the left side of the heart in people with severe heart failure. The goal was to see if pacing from inside the heart (endocardial) works better than the usual method from outside (epicardial). Only 6 adults took part, and the main …

This study tested a special balloon coated with the drug everolimus in 51 people whose previously placed heart stents had become blocked again. The balloon is inflated inside the artery to deliver the drug directly to the blockage, aiming to keep the artery open. The main goals w…

This phase 2 trial tested a drug called orticumab in 77 adults with moderate-to-severe psoriasis who also had cardiometabolic risks (like obesity and high cholesterol). The goal was to see if orticumab could safely reduce skin plaques and inflammation linked to heart disease. Par…

This early study tested a single injection of HM2002, a circular RNA, given directly into the heart muscle during bypass surgery. Only 3 people with heart failure took part. The main goal was to check safety, not to prove it works. The study is complete, but results are not yet a…

This study looked at whether dapagliflozin, a diabetes medication, can improve how the heart uses sugar and blood flow in people with type 2 diabetes and stable coronary artery disease. 25 adults took either the drug or a placebo for 4 weeks. The goal was to see if the drug helps…

This study tested whether a breathing muscle training device could improve blood flow in the hearts of people with coronary artery disease. Forty participants used the device daily for six weeks. Researchers compared high-intensity versus low-intensity training to see if it incre…

This study looked at whether a 12-week course of glecaprevir/pibrentasivir can safely cure hepatitis C in heart transplant patients who got the virus from infected donors. Fifty adults on the transplant waitlist were enrolled, and those who received a hepatitis C-positive heart w…

This completed study looked at over 3000 people with coronary artery disease to compare two types of drug-eluting stents: everolimus-eluting (Xience/Promus) and sirolimus-eluting (Cypher). The goal was to see which one better prevents major heart problems like heart attacks or th…

This study looked at over 5,500 heart patients in Korea who had a drug-coated stent and took two blood thinners for about a year. After that, they were given either clopidogrel or aspirin alone for up to two more years. The goal was to see which drug better prevents heart attacks…

This study looked at whether doing cardiac rehab at home, or a mix of home and clinic sessions, works as well as going to the clinic for all sessions. 206 heart patients participated, using a mobile health platform and home exercise. The goal was to see if flexible options could …

This study tested two different drug-coated stents (everolimus-eluting vs. sirolimus-eluting) in 1,466 people with narrowed heart arteries. It also compared taking the blood thinner clopidogrel for 6 months versus 12 months after stenting. The goal was to see which stent and whic…

This study tested a once-daily pill called orforglipron against insulin glargine in nearly 2,750 adults with type 2 diabetes, obesity or overweight, and increased cardiovascular risk. The main goal was to see if orforglipron could reduce major heart events like heart attacks or s…

This study tested whether quercetin, a natural compound found in fruits and vegetables, can reduce inflammation and signs of cell aging in 100 people undergoing heart bypass surgery. Participants received quercetin or a placebo before and after surgery. The goal was to see if que…

This study tested two experimental drugs, DFV890 (a daily pill) and MAS825 (a single shot), in 31 adults with coronary heart disease and a blood condition called CHIP. The goal was to see if these drugs could reduce specific markers of inflammation linked to heart risk. The trial…

This early study tested whether placing a thin layer of human amniotic membrane on the heart during bypass surgery could reduce inflammation and prevent post-operative atrial fibrillation (an irregular heartbeat). Twenty-seven patients were randomly assigned to receive either the…

This study looked at two ways to treat heart attack patients who have multiple blocked arteries. One group had all blockages fixed in a single procedure, while the other group had the main blockage fixed first and the others in a separate procedure later. The goal was to see if t…

This study tested two ways of managing breathing during heart bypass surgery to see which better prevents lung complications. Over 1,500 adults having planned heart surgery were randomly assigned to either no breathing support or gentle, low-volume breaths while on the heart-lung…

This study tested an experimental daily pill called DFV890 in 24 adults with coronary heart disease and high levels of inflammation (measured by hsCRP). The goal was to see if the drug could safely lower certain inflammatory markers linked to heart risk. Participants took the pil…

This study tested a new device called the Wave PRO System that helps improve blood flow in people with chronic stable angina (chest pain). The device works by gently squeezing the legs to push more blood to the heart. The study included 52 adults with mild to moderate coronary ar…

This study looked at 1,500 people with severe blockages in three heart arteries. It compared a less invasive procedure using a pressure wire to guide stent placement (FFR-guided PCI) with open-heart bypass surgery (CABG). The goal was to see if the stent approach could match the …

This study tested a two-step procedure for people with severely hardened heart arteries. First, doctors used a special device to shave away hard plaque, then inflated a drug-coated balloon to open the artery. The goal was to see if this approach could safely improve blood flow an…

This study looked at 218 older adults (over 60) with severe calcium buildup in their heart arteries. Researchers compared a drug-coated balloon to a drug-coated stent to see which worked better. The goal was to find a way to open blocked arteries and improve blood flow without ne…

This study tested whether a special monitor placed in the breathing tube during heart bypass surgery could help doctors manage fluids and blood flow better. 100 adults having elective coronary bypass surgery were split into two groups: one got standard care, the other used the EC…

This study tested whether using low tidal volume (gentle) ventilation during heart-lung bypass surgery can lower the risk of postoperative delirium—a state of confusion that can slow recovery. Researchers compared 130 patients who received either low tidal volume ventilation or n…

This study looked at how well the PROMUS PREMIER stent works in everyday medical practice in China. Over 2,000 people with coronary artery disease received the stent and were followed for 12 months to track major heart problems like heart attacks or the need for another procedure…

This study looked at how different amounts of aerobic exercise affect blood flow and fitness in 115 people with heart disease. Participants joined a cardiac rehab program and were monitored for changes in skin blood flow and oxygen use during exercise. The goal is to find the mos…

This study tested a new balloon catheter called SINOMED CBC for treating narrowed coronary arteries. It involved 136 patients with stable or unstable angina or evidence of heart muscle ischemia. The device was compared to a standard balloon catheter to see if it was as safe and e…

This study tested whether removing the ligament of Marshall during coronary artery bypass surgery could prevent a common complication: atrial fibrillation. 220 high-risk patients were randomly assigned to get the extra procedure or standard surgery alone. The goal was to see if t…

This study tested whether taking a daily probiotic drink called Goodbelly for 6 weeks could improve blood vessel function and reduce inflammation in 215 adults with heart disease or type 2 diabetes. Researchers measured blood markers and gut bacteria to see if the probiotic made …

This study tested a new drug-coated stent called EvroSure in 888 people with blocked heart arteries. The stent releases medicine to keep the artery open and prevent future blockages. Researchers tracked major heart events like heart attacks or the need for repeat procedures at 30…

This study tested a special balloon coated with sirolimus, a drug that helps keep heart arteries open after a blockage is cleared. 360 adults with coronary artery disease were treated and followed for 12 months to see if the balloon reduced major heart problems like heart attack …

This study tested whether a single dose of dantrolene, a muscle relaxant, could reduce the risk of dangerous heart rhythms in 68 people with structural heart disease who were scheduled for a procedure to treat ventricular tachycardia. Participants received either dantrolene or a …

This study tested whether the anti-inflammatory drug colchicine can reduce complications like irregular heartbeat, heart sac inflammation, and heart damage after coronary artery bypass surgery. 100 patients who had a recent heart attack and needed bypass surgery were randomly ass…

This study looked at 556 people with coronary artery disease to confirm that the Orsiro drug-eluting stent is safe and effective in everyday use. The stent releases sirolimus to prevent artery re-narrowing. Researchers tracked how many patients had heart-related death, heart atta…

This study looked at whether lowering the use of anticholinergic drugs—common in older adults and linked to confusion and frailty—before and after heart surgery can help patients recover better. Researchers studied 120 adults having elective coronary artery bypass surgery. They m…

This study tested a device that uses sound waves to break up calcium deposits in heart arteries before placing a stent. It involved 145 people with severe coronary artery disease. The goal was to see if the device is safe and helps stents work better.

This study tested whether adding oat bran to the diet could improve cholesterol levels and reduce inflammation in people with coronary artery disease. Thirty-two patients who recently had angioplasty took part. Half ate 28 grams of oat bran daily for two months, while the other h…

This study looked at whether a drug-coated balloon (DCB) can safely treat blocked heart arteries, possibly avoiding the need for a permanent stent. Researchers followed 2487 patients who received the balloon instead of a stent. The goal was to see how well the balloon prevents he…

This study tested whether intensive dental cleaning and oral hygiene advice can improve gum health and also affect markers of heart disease and type 2 diabetes. About 200 adults with gum disease and either heart disease or diabetes (or prediabetes) took part. Researchers measured…

This early study tested a new device called the Supira System in 15 people with coronary artery disease undergoing high-risk angioplasty. The device temporarily helps the heart pump blood during the procedure. The goal was to see if it is safe and works as intended, not to cure t…

This small completed study looked at a blood filtering procedure called double-filtration plasmapheresis (DFPP) in 5 kidney dialysis patients with very high levels of lipoprotein(a), a fatty substance linked to heart disease and blood clots. The goal was to see if DFPP could lowe…

This study looked at how well the Xience Sierra drug-coated stent works in a broad group of heart disease patients, including those with diabetes or prediabetes. Over 1,700 participants received the stent during a routine procedure to open blocked arteries. Researchers tracked he…

This completed study looked at whether evolocumab, a cholesterol-lowering injection, can reduce major heart problems in people who had a heart attack and have several blocked arteries. Researchers analyzed data from 1862 patients to see if the drug lowers the risk of cardiac deat…

This study looked at whether adding a traditional Chinese herbal powder called Yixin Powder to standard heart medications helps people with stable angina (chest pain) from coronary heart disease. 70 adults aged 40-70 with a specific Chinese medicine pattern took part. The goal wa…

This study tested whether metoprolol, an FDA-approved heart medication, can reduce heart damage after surgery in people with coronary artery disease. 72 adults aged 50 and older who were not already on beta-blockers took part. The drug was given after anesthesia and during hospit…

This trial tested a new type of stent (a small mesh tube) that slowly dissolves after being placed in a heart artery. The stent is coated with a drug to prevent the artery from narrowing again. Over 1600 patients with stable heart disease or a mild heart attack received either th…

This study tested whether applying a patient's own platelet-rich plasma (PRP) to the chest wound during heart surgery reduces infections and improves healing. 98 adults undergoing bypass surgery were randomly assigned to receive PRP or standard wound closure. Results showed that …

This study tested whether a smartphone app and regular phone calls could help people with heart or lung disease complete rehabilitation at home instead of going to a clinic. The program included exercise tracking, education, and counseling over 12 weeks. Researchers wanted to see…

This study tested two methods to prepare hardened (calcified) heart arteries before placing a stent: a cutting balloon and a shockwave device. About 413 adults with moderate to severe artery hardening took part. The goal was to see which method helps the stent fit better and work…

This study tested a program to help people with heart disease, stroke, or heart failure in India. The program used non-physician health workers, text messages about healthy living, and a computer tool to help doctors make decisions. 410 adults took part to see if the program impr…

This study looked at whether high-intensity breathing exercises (inspiratory muscle training) can improve blood vessel function and artery stiffness in people with heart disease before they start cardiac rehab. Eleven adults who had heart surgery or related conditions took part. …

This study tracked 161 patients with coronary artery disease who were treated with the Essential Pro device in routine hospital practice. The goal was to confirm the device's safety and performance, such as freedom from heart attack or repeat procedures. Results support its conti…

This study tested whether using a measure of oxygen in the blood (SvO2) to guide red blood cell transfusions during heart surgery could reduce how many patients receive transfusions. Over 600 adults undergoing on-pump cardiac surgery were randomly assigned to either standard rest…

This study tested a transitional care model for 108 patients with coronary heart disease who had a stent procedure. The program used structured follow-up and WeChat-based education to help patients take their medications correctly and improve self-care. Researchers measured medic…

This study looked at two types of resistance training—elastic bands and free weights—in 42 people recovering from coronary artery bypass grafting (CABG). The goal was to see which method better improves lung function, physical ability, and quality of life during the early recover…

This study tested a very small balloon catheter (Sapphire 3) in 170 people with severely blocked heart arteries (chronic total occlusions). The balloon was used to open the blockage before placing a stent. The main goal was to see if the device could be safely delivered, inflated…

This study tested whether a drug called alirocumab, which lowers cholesterol, can reduce heart disease risk in people with HIV. The trial involved 118 adults aged 40 and older with well-controlled HIV and high heart disease risk. Participants received either alirocumab or a place…

This study looked at a device called Coroflex ISAR Neo, a stent used to open blocked heart arteries. Researchers wanted to see if it was safe and worked well. Over 3,500 people with coronary artery disease took part. The main goal was to see how many needed a repeat procedure wit…

This study tested three doses of argatroban, a blood thinner, in 140 patients undergoing elective heart stent procedures. It compared argatroban to the standard blood thinner heparin, both given with clopidogrel and aspirin. The goal was to see how well argatroban prevents blood …

This completed trial looked at whether taking two cholesterol-lowering drugs (rosuvastatin and ezetimibe) is more effective and safer than taking just one (rosuvastatin) for people with heart disease. 66 adults with high cholesterol were randomly assigned to one of the two treatm…

This study looked at a 'hybrid' approach for people with severe coronary artery disease, combining bypass surgery for the main heart artery with a stent procedure for other blocked arteries. Researchers tracked 2000 patients to see if this combined treatment reduced the risk of d…

This study looked at the best way to use drug-eluting stents (tiny mesh tubes that release medication) in patients with coronary artery disease where the blockage is at a fork (bifurcation). 413 patients were randomly assigned to get stents in both branches of the fork or only in…

This study tested two ways to place stents in heart arteries that have a branch (bifurcation). 425 patients with chest pain were randomly assigned to either the 'crush' or 'culotte' technique. Researchers tracked heart-related deaths, heart attacks, stent clots, and the need for …

This study tested a special stent made of magnesium that slowly dissolves in the body. The stent releases a drug to prevent scarring and was used in 20 patients with complex blockages where arteries branch. The goal was to see if it is safe and works well for these tricky cases.

This study tested a special balloon coated with medication to reopen completely blocked heart arteries in 309 people. The balloon delivers drug to keep the artery open without leaving a permanent stent. Researchers checked if the artery stayed open and if there were any heart pro…

This study looked at how well the Ultimaster stent works compared to other stents used to open blocked heart arteries. About 1,000 adults with coronary artery disease who received the Ultimaster stent were followed to track deaths, heart attacks, and the need for repeat procedure…

This completed trial tested a low-AGE diet in 36 adults aged 55-65 with type 2 diabetes, coronary artery disease, and overweight. Participants were instructed to boil or steam food instead of frying, grilling, or roasting. The diet reduced blood levels of a harmful compound calle…

This study looked at a special balloon coated with sirolimus, a drug that helps keep arteries open, to treat large blockages in the heart's blood vessels. Over 300 adults with coronary artery disease were treated and followed for one year to see if they needed another procedure t…

This study tested two different solutions used to protect the heart during bypass surgery. One is a modified version of a common fluid (Ringer acetate), the other is a standard solution (HTK). Researchers checked which one led to fewer abnormal heart rhythms and less heart muscle…

This study tested whether a stellate ganglion block (a nerve injection) before coronary artery bypass surgery can prevent new atrial fibrillation, a common complication. 108 patients were included. The approach aims to calm the nervous system and reduce inflammation. Results coul…

This early-stage study tested the safety of Atorvo+™, a new drug that combines the common cholesterol-lowering medication atorvastatin with cannabidiol (CBD). The trial involved 24 healthy adults aged 40-75 to see how the body processes the drug and if it causes any side effects.…

This completed study looked at 60 postmenopausal women with stable coronary artery disease. Researchers tested whether adding a daily 1000 mg quercetin supplement to standard atorvastatin treatment could affect levels of estrogen and a protein called SIRT1, which are linked to he…

This study tested whether using cardiac MRI to guide ablation (a procedure that destroys small areas of heart tissue) can improve outcomes for people with ventricular tachycardia, a dangerous fast heart rhythm. 104 adults with structural heart disease were randomly assigned to on…

This early study tested a new tool called the FastWire System in 8 people with severely blocked leg arteries. The goal was to see if the device could safely cross the blockage and allow doctors to place other treatments to restore blood flow. The study focused on safety and wheth…

This study tested a virtual cardiac rehabilitation program using a smartphone app, a fitness wristband, and a blood pressure monitor for people who recently had a heart attack, heart surgery, or a stent. The goal was to see if this home-based program could improve walking ability…

This study tested a special balloon coated with sirolimus, a drug that helps prevent arteries from narrowing again after angioplasty. It included 110 adults with stable or unstable coronary artery disease who had long blockages (at least 25 mm) in their heart arteries. The main g…

This study tested whether a device that gently stimulates a nerve in the ear (vagus nerve) can help control blood pressure during heart stent placement. 480 adults with coronary artery disease and high blood pressure were randomly assigned to receive either real or sham stimulati…

This completed trial tested whether taking two blood thinners (clopidogrel and aspirin) for 12 months after a heart stent procedure is better than aspirin alone for people with multiple blocked coronary arteries. Over 8,000 patients were enrolled across 100 centers. The main goal…

This study tested whether starting gentle exercise soon after coronary artery bypass surgery, guided by wearable heart monitors, improves patients' ability to walk and function. 84 stable patients were split into three groups: usual care, usual care plus cycling, or usual care pl…

This study looked at a special drug-coated stent (Genoss DES) in 200 people with coronary artery disease who are at high risk for heart attacks. The stent slowly releases sirolimus to help keep the artery open. Researchers tracked how many patients had heart-related death, heart …

This study followed 204 people with coronary artery disease who received the Ultimaster stent, a thin mesh tube coated with a drug that slowly releases to prevent arteries from clogging again. The stent's coating dissolves over 3-4 months. Researchers tracked safety and effective…

This study tested whether taking aspirin twice a day (200 mg total) works better than the standard once-daily dose (100 mg) to prevent another heart attack, stroke, or urgent heart procedure in diabetic patients who recently had a heart attack. About 2,500 participants were follo…

This study tested whether rosuvastatin, a common cholesterol-lowering drug, could reduce early signs of artery hardening in 121 people with ANCA-associated vasculitis. Participants were in remission and received either rosuvastatin or a placebo for up to 2 years. The goal was to …

This study looked at whether the flu vaccine can reduce inflammation in people with stable coronary artery disease. Inflammation plays a key role in heart disease progression. The trial involved 47 adults aged 60 and older with stable heart disease, who received the flu vaccine e…

This study looked at whether people with diabetes and a high risk of bleeding can safely stop taking two blood thinners (DAPT) just one month after getting a special stent, instead of the usual six months. Doctors used a special camera (OCT) to check if the artery had healed enou…

This study tested whether a 12-week home-based telerehabilitation program works as well as traditional center-based cardiac rehab for people who had coronary artery bypass surgery. 110 stable patients, aged 30 to 75, were enrolled. The main focus was on changes in exercise capaci…

This study looks at whether a blood thinner called ticagrelor can lower heart attack risk in people with high-risk fatty plaques in their heart arteries. Researchers used a special PET scan to find these plaques in 220 patients with coronary artery disease. Participants took eith…

This study looked at whether giving ulinastatin during heart surgery can lower the chance of lung complications like infections or breathing failure. Researchers analyzed data from over 4,500 patients and also used computer models to understand how the drug works. The results sug…

This study looked at whether giving patients their own blood left over in the heart-lung machine after bypass surgery could reduce the need for donor red blood cell transfusions. Sixty adults having elective coronary bypass were split into two groups: one received the leftover bl…

This study looked at 3048 adults with heart or blood vessel disease to see if lowering LDL ('bad') cholesterol to a very low level (below 55 mg/dL) is better than the standard target (below 70 mg/dL). Participants received either a statin alone or a statin plus ezetimibe. The goa…

This early study tested whether a biologic called PEP, made from donor blood particles, is safe to infuse into heart arteries right after stent placement. Nine patients received a single dose during catheterization. The goal was to see if PEP could reduce heart damage, but the ma…

This study tested whether a special balloon that uses sound waves to break up calcium (balloon lithoplasty) works better than standard balloons for preparing severely calcified coronary arteries before placing a stent. The trial involved 200 adults with stable heart disease or no…

This completed trial tested an Ayurvedic herbal supplement called Maharishi Amrit Kalash (MAK) against vitamins C+E and a placebo in 143 Black adults aged 55+ with heart disease or high risk. The goal was to see if MAK improves blood vessel function, measured by how well arteries…

This study tested a nurse-led disease management program using a mobile app and telehealth for people with coronary artery disease at high risk of returning to the hospital. The program aimed to help patients manage their condition through education, medication support, and lifes…

This study tested a simple method to prevent wrist artery blockage after a common heart procedure. Over 1500 patients had their wrist artery pressed with a special thick gauze pad plus a standard device, or just the device alone. The goal was to see if the gauze method reduced ar…

This study tested whether adding a special pressure wire measurement (FFR) to standard angiography helps doctors decide the best treatment for people with multiple blocked heart arteries. Over 900 patients were randomly assigned to get either angiography alone or angiography plus…

This study looked at whether using a person's genetic information to choose their blood-thinning medication (clopidogrel or an alternative) leads to better outcomes after a heart procedure. 283 adults with chronic coronary artery disease who had a stent placed were split into two…

This study tested whether an artificial intelligence (AI)-enhanced mobile app can help people with coronary heart disease manage their health after leaving the hospital. Over 1,100 participants used the app to track health metrics, receive medication reminders, and get lifestyle …

This study tested whether Yangxinshi pills, a traditional Chinese medicine, can improve exercise tolerance in people who recently had a heart stent (PCI). Over 600 participants received either Yangxinshi or the drug Trimetazidine for comparison. The main goal was to see if Yangxi…

This study tested a new method to rebuild bone in the upper front jaw for dental implants. Researchers used custom-made donor bone blocks, designed with computer software, to support immediate implant placement. Twenty patients with bone loss from previous failed implants were tr…

This study tested a stent retriever device, already used for strokes, to remove clots during heart attacks. The goal was to reduce damage to small heart blood vessels caused by clot fragments. 81 patients with severe heart attacks were enrolled to see if the device works better t…

This study compares a new ultra-high-resolution CT scanner (UHR-CT) to the standard invasive coronary angiography for detecting significant blockages in the heart's arteries. It focuses on patients with severe calcium buildup or stents, where regular CT scans often fall short. Th…

This study tested a new type of CT scanner (photon-counting detector CT) to see if it gives clearer images of heart arteries and blood flow compared to standard CT and nuclear stress tests. Researchers enrolled 276 adults with suspected coronary artery disease. The goal was to se…

This study looked at whether a special eye scan (SS-OCTA) can detect signs of cardiovascular disease. Researchers compared retinal blood vessel changes to results from a standard carotid ultrasound in 42 adults. The goal was to see if the eye scan could predict the presence or se…

This study looked at whether using different blood test cutoffs for men and women can better diagnose heart attacks. Current tests use the same cutoff for both sexes, which may miss heart attacks in women and over-diagnose them in men. Researchers tested new sex-specific cutoffs …

This completed trial tested whether an artificial intelligence (AI) tool could help doctors decide which low-risk patients with suspected heart disease should get a safer, non-invasive CT scan instead of an invasive angiogram. The study involved 251 adults referred for non-urgent…

This study tested whether a simple bedside heart ultrasound measurement, called the S' wave, can help emergency doctors quickly identify acute coronary syndrome (heart attack or unstable angina) in patients with chest pain. Researchers enrolled 66 adults who came to the ER with c…

This study compared two contrast agents (Dotarem and Gadovist) used in cardiac MRI to see which provides clearer images of heart muscle damage. 120 adults with coronary artery disease or cardiomyopathy received one of the two dyes during their scan. Researchers rated image qualit…

This study tested whether an AI-powered smart stethoscope can accurately detect structural heart disease in over 6,600 students aged 10-18 in China. Trained staff used the device to listen to heart sounds, and the AI flagged potential issues. Students with positive results, plus …

This study tested whether a new, non-invasive finger sensor (Oxygen Reserve Index, or ORI) can predict breathing complications after coronary artery bypass surgery better than standard spirometry. Researchers measured ORI and spirometry in 142 adults before surgery and tracked lu…

This completed study tested whether a special ultrasound scan (IVUS) of plaque buildup in heart arteries can accurately diagnose reduced blood flow (functional myocardial ischemia). Researchers enrolled 105 adults with coronary artery disease and compared IVUS results to the stan…

This study compared two types of heart scans—CT and PET—to see if CT can measure blood flow to the heart as accurately as PET, which is the current gold standard. Researchers enrolled 20 adults with suspected coronary artery disease. Each participant received both a CT scan and a…

This early-phase study tested a new radioactive tracer called Ga-68 Galmydar for PET scans of the heart. The goal was to see if it can accurately show blood flow to the heart muscle in people with or without coronary artery disease. Fifteen adults received the tracer and underwen…

This study tested a new, non-invasive imaging method to measure blood flow in the heart muscle. It involved 36 people with coronary artery disease who already needed a heart catheterization. The goal was to see if the new scan could give the same results as the standard invasive …

This study tested whether a computer algorithm can spot signs of coronary artery disease by analyzing facial photos. Researchers enrolled 100 adults from the community who had a moderate risk of heart disease. The goal was to see how well the algorithm could identify those with b…

This study tested whether a special CT scan called FFRct can help doctors better manage stable chest pain compared to standard guidelines. About 1,400 adults with chest pain but no other major heart issues took part. The goal was to see if using FFRct as the first test reduces th…

This study tested whether artificial intelligence can predict coronary artery disease using non-contact information, such as facial images or other external data, without any needles or scans. Researchers enrolled nearly 3,000 people suspected of having heart disease and compared…

This study tested a new contrast agent called NH002 in 36 adults with heart disease. The agent is used during heart ultrasound to make the heart's chambers and borders clearer. The main goal was to check safety by monitoring vital signs, heart activity, and allergic reactions aft…

This study tested a new software program that analyzes heart angiogram images to measure blood flow blockages without needing to insert a pressure wire into the artery. Researchers reviewed the records of 100 patients who had both an angiogram and an invasive pressure measurement…

This study tested whether a computer analysis of CT scans (called FFRCT) can better guide decisions about heart artery blockages compared to usual care. About 584 people with suspected coronary artery disease took part. The goal was to see if using FFRCT reduces the number of unn…

This trial tests whether a 12-week program led by a heart health educator can lower cholesterol and improve heart health in spouses, siblings, and children of people hospitalized with coronary heart disease. Participants work with an educator to create a personal plan for smoking…

This study tested whether making a small opening in the lining around the heart (called a left posterior pericardiotomy) can prevent new atrial fibrillation after coronary artery bypass surgery. 270 adults having bypass surgery were randomly assigned to get this extra cut or not.…

This large observational study followed over 135,000 Chinese women aged 40-70 to see if eating soy food reduces the risk of heart attacks and fatal heart disease. Researchers tracked participants' soy intake and heart health over time. The study aims to provide clues about diet a…

This study looked at how often older adults with heart disease risk factors should exercise to improve fitness and blood pressure. Twenty-two participants did combined training either twice or three times a week for 12 weeks. The goal was to see which frequency worked better for …

This study tested whether giving IV acetaminophen (Tylenol) every 6 hours during and after heart surgery could prevent delirium—sudden confusion—in patients aged 60 and older. Delirium is common after heart surgery and can lead to longer hospital stays and other problems. The tri…

This study tested an 8-week digital lifestyle program called MYCardio-PEER for low-income adults at risk of heart disease. Participants received weekly videos and infographics on healthy eating and exercise, plus group chats with peer leaders. The goal was to see if the program i…

This study tested whether making a small cut in the sac around the heart (posterior pericardiotomy) during open-heart surgery can prevent a common complication called atrial fibrillation. 210 adults having elective heart surgery in Yemen were randomly assigned to receive either t…

This study looked at whether a home-based physical activity program and computer-based cognitive training could help prevent memory loss in older women with heart disease. 253 women aged 65 and older participated. The goal was to see if these lifestyle changes could improve memor…

This large study tested whether giving sodium bicarbonate (a type of fluid) or N-acetylcysteine (a supplement) before and after angiography could prevent serious kidney problems, including death or need for dialysis. Over 5,000 high-risk patients with kidney disease took part. Th…

This completed study tested whether sending behavioral nudges through Denmark's official electronic letter system could increase flu vaccination among adults aged 18-64 with chronic diseases. Over 300,000 participants were randomly assigned to receive different types of letters o…

This study compares two types of nerve blocks (ESPB and SPSIPB) to manage pain after heart bypass surgery. About 60 adults aged 18-80 having planned bypass surgery will take part. The goal is to see which block reduces the need for painkillers and improves comfort after surgery.

This study tested whether regular phone calls from a nurse after coronary artery bypass surgery could help patients manage symptoms and take better care of themselves at home. 72 patients were split into two groups: one received standard care, and the other got scheduled phone co…

This study tests whether wearing virtual reality glasses during femoral sheath removal — a routine step after a heart catheterization — can lower pain, anxiety, and changes in vital signs. About 60 adults undergoing this procedure will be randomly assigned to either use VR glasse…

This pilot study tested whether adding a 16-week meditation program to standard cardiac rehabilitation helps people with coronary artery disease feel less stressed and anxious. Forty participants were split into two groups: one did meditation plus rehab, the other did rehab alone…

This study tested whether giving the pain medicine sufentanil as a continuous drip during heart surgery helps patients wake up and leave the ICU sooner compared to giving it as single shots. 65 adults having planned heart surgery took part. The goal was to see if the drip method …

This study looked at 50 adults having heart bypass surgery to see if one sedative (dexmedetomidine) causes less confusion after surgery than another (midazolam). The goal was to find a way to reduce postoperative delirium, a common problem after heart surgery. Researchers checked…

This study looked at two methods to reduce pain after heart surgery through a cut in the chest bone. 120 adults received either a nerve block near the breastbone, pain medicine injected into the wound, or standard painkillers. Researchers measured pain levels using a saliva test …

This study tested two types of nerve blocks (SAP and PECS II) to see if they could reduce pain after coronary artery bypass grafting. 243 adults received one of the blocks or standard care. Researchers measured pain scores, opioid use, and recovery times. The goal was to find a b…

This study looked at whether Emotional Freedom Technique (EFT), a therapy that involves tapping on specific body points, can reduce pain, pain-related beliefs, and anxiety in people recovering from coronary artery bypass graft (CABG) surgery. Researchers enrolled 66 adults and me…

This study tested whether watching a short video before coronary bypass surgery could reduce confusion (delirium) in the ICU and speed up recovery. 220 adults were randomly assigned to either watch the video or receive standard care. The video explained the surgery, ICU environme…

This study tested whether a nurse-led program, including education and an animated video, could reduce anxiety in 60 adults scheduled for coronary artery bypass graft surgery. Participants were split into two groups: one received the extra program, the other standard care. Resear…

This completed trial tested an 8-week program called Healing Hearts Together (HHT) for couples where one partner has heart disease. 474 couples attended weekly group sessions focused on communication, emotional support, and heart health. The goal was to see if the program improve…

This study tested whether giving vascular surgery patients access to a website with educational videos could reduce their anxiety before the operation. 250 patients were split into two groups: one got the videos, the other did not. Researchers measured anxiety using a simple 0-to…

This study looked at whether amlodipine, a blood pressure medicine, can help people with stable angina (chest pain) who already have stents but still have narrowed arteries. About 211 participants took amlodipine or no calcium-channel blocker for 9 months. The main goal was to se…

This study compared two ways to control pain after minimally invasive heart bypass surgery: a newer erector spinae plane block (ESPB) versus the standard paravertebral block (PVB). 140 patients received one of the two blocks using the numbing drug ropivacaine. The goal was to see…

This study tested whether adding mindfulness-based stress reduction (MBSR) to aerobic exercise helps heart patients who recently had a stent procedure. 150 participants were split into two groups: one did only aerobic training, the other added daily mindfulness sessions. Research…

This study tested whether a 20-minute session of nurse-led spiritual care, including prayer and relaxation techniques, could help heart surgery patients feel less anxious and have more stable blood pressure and heart rate before their operation. 248 adults in Indonesia took part.…

This study looked at whether a short virtual reality mindfulness session could help patients feel less anxious and stressed after heart surgery. 34 adults who had heart bypass or valve repair took part. One group did a 15-minute VR mindfulness exercise, while the other group rece…

This study tested whether a parasternal block—an injection of the numbing drug ropivacaine into the chest wall—could reduce the amount of anesthetic needed to keep heart rate and blood pressure stable during coronary artery bypass surgery. Thirty-five patients were randomly assig…

This study tested whether avoiding morphine during heart surgery could reduce common complications like breathing problems, confusion, and gut issues. 268 adults having planned heart surgery were randomly assigned to receive either standard morphine-based anesthesia or a combinat…

This study looked at 60 adults having heart bypass surgery to compare two types of chest wall nerve blocks for pain control. One group got a combination of two blocks, the other got a different pair. Researchers measured pain scores and how much extra pain medicine patients neede…

This study looked at whether circuit training, with or without added arm and leg resistance exercises, could help people who had heart surgery breathe easier at night and improve their daily function. Sixty adults aged 35 to 65 who had bypass surgery 3 to 6 months earlier took pa…

This study tested whether special nerve blocks (fascial plane blocks) can improve pain control and reduce time on a breathing machine after open-heart surgery. 206 adults having heart surgery were divided into two groups: one received the nerve blocks plus standard pain care, the…

This study looked at whether using an incentive spirometer (a device that encourages deep breathing) after coronary artery bypass surgery helps improve oxygen levels and vital signs. 58 patients were randomly assigned to receive either standard care or standard care plus the brea…

This study tested whether using a vibrating device, alone or with a cold gel pack, could reduce pain and anxiety when chest tubes are removed after coronary artery bypass surgery. 93 patients were split into three groups: vibration only, vibration plus cold, or standard care. Res…

This study tested whether adding a diaphragm release technique to standard cardiac rehabilitation could improve sleep quality and lung function in 30 patients who had coronary artery bypass surgery. One group received standard rehab plus the diaphragm release, while the other rec…

This study looked at whether Clinical Pilates exercises can help people who have had coronary artery bypass grafting (CABG) overcome kinesiophobia — a fear of movement that can slow recovery. 36 patients who were stable after surgery and had kinesiophobia took part. They did 30-m…

This study looked at whether giving precise amounts of fluid during coronary artery bypass surgery can reduce the risk of postoperative cognitive dysfunction (POCD) — problems with memory, focus, and thinking that affect up to 70% of heart surgery patients. Researchers monitored …

This study tested whether two types of nerve blocks (SAP and PECS) can reduce pain and shorten the time patients need a breathing tube after heart bypass surgery. 243 adults undergoing open heart surgery received either a nerve block or standard pain medication. Researchers measu…

This study tested whether a 3-month yoga program could improve physical and mental health in adults over 65 who had recently finished cardiac rehab. Participants attended yoga twice a week. Researchers measured balance, muscle strength, anxiety, and mood. The goal was to see if y…

This study looked at whether playing music during an angiography procedure can lower patients' anxiety and keep their vital signs stable. Fifty adults with coronary artery disease were randomly assigned to either listen to music during the procedure or receive standard care. Rese…

This study tested whether adding dexmedetomidine to a standard numbing medicine (bupivacaine) in chest nerve blocks could provide better pain relief after heart surgery. Sixty adults having open-heart surgery through a chest incision received the nerve block with or without the e…

This study tested whether adding a recto-intercostal fascial plane block (RIFPB) to a standard pecto-intercostal fascial plane block (PIFPB) improves pain control after open-heart surgery. Forty adults scheduled for heart surgery received both blocks with the anesthetic bupivacai…

This study tested whether a special 'ultra-fast-track' anesthesia method helps patients recover faster after coronary artery bypass surgery. In this approach, patients wake up and have their breathing tube removed in the operating room or within the first hour, instead of later i…

This study tested whether adding a tramadol injection to a continuous local anesthetic (levobupivacaine) delivered through a wound catheter can reduce the need for morphine after heart surgery via sternotomy. 160 adults undergoing various heart surgeries were enrolled. The goal w…

This study looked at 40 men over 45 with high blood pressure and heart disease to compare two types of exercise: interval training and continuous training, both including aerobic and resistance exercises. The goal was to see which better improves heart function and blood pressure…

This study tested whether using virtual reality (VR) during the removal of a tube from the groin after a heart procedure could reduce pain and anxiety. One hundred adults were randomly assigned to either wear VR goggles showing calming scenes or receive standard care. Researchers…

This study looked at whether having a supervisor guide breathing exercises helps heart bypass patients recover lung function better than doing them alone. Thirty-eight adults who had coronary artery bypass surgery did incentive spirometry (a breathing device) twice daily for thre…

This study looked at two ways to manage pain after coronary artery bypass surgery. All 72 patients received a standard parasternal nerve block, and half also got an additional serratus anterior plane block. Researchers measured pain scores and how much pain medicine patients need…

This study tested whether using nerve blocks and sedation instead of general anesthesia could make upper leg amputation surgery safer for high-risk patients, such as the elderly or those with diabetes or heart disease. Thirty participants received ultrasound-guided nerve blocks a…

This study looked at 102 children who had surgery for a heart problem present at birth. After surgery, they were placed on their stomachs with their heads raised at different angles (10°, 30°, or 45°) to see which angle best helped their heart and lungs recover. The goal was to f…

This study tested whether elastic therapeutic taping can reduce pain after open-heart surgery (CABG). 195 patients were randomly assigned to receive real tape, placebo tape, or another supportive treatment near the surgical site. Neither patients nor researchers knew who got whic…

This study tested a breathing exercise called the active cycle breathing technique in 120 adults who had just had heart surgery. The exercise combines controlled breathing, deep breaths, and huffing or coughing to help clear the lungs and improve breathing. Researchers measured w…

This study tested whether using virtual reality (VR) in the waiting room could reduce anxiety in 156 adults about to undergo a heart catheterization. Participants used VR while waiting for their procedure, and researchers measured their stress levels using heart rate monitors and…

This study looked at whether giving specific nerve blocks (PECS II, parasternal, and serratus plane blocks) before surgery can reduce pain after minimally invasive heart bypass surgery (MIDCAB). Researchers compared 88 patients who either received the blocks or standard painkille…

This study tested a safe early mobilization plan for 60 patients who had coronary artery bypass surgery. The plan included gentle activities like sitting up, deep breathing, and walking starting the day of surgery. The goal was to see if this approach could reduce dizziness, impr…

This study looked at whether music therapy can reduce pain and anxiety in people who had coronary artery bypass grafting (CABG). Sixty adults were enrolled, and those in the music group listened to music before and during surgery. Afterward, they reported their pain and anxiety l…

This study tested whether a nerve block called erector spinae plane block (ESPB) can improve pain control and recovery in adults undergoing open-heart surgery. Sixty-six participants received either the nerve block or standard IV opioids. Researchers measured pain scores, need fo…

This study tested whether a nerve block given before heart surgery can reduce pain and the need for opioids afterward. 76 patients received either the block or a placebo injection. Researchers measured pain scores and opioid use in the first 24 hours after surgery.

This study tested a combination of brain monitoring and specific drugs during heart surgery to see if it could reduce confusion, pain, and blood pressure problems afterward. 70 older adults (60+) having heart bypass or valve surgery took part. The approach used EEG monitoring and…

This study tested a 9-week internet-based cognitive behavioral therapy (CBT) program designed to reduce stress, anxiety, and depression in people with stable heart disease. 215 adults with heart disease and elevated stress or mood symptoms took part. The program was personalized …

This study tested whether a structured early exercise program helps people recover better after coronary artery bypass surgery. Forty adults who had their first bypass surgery were split into two groups: one received standard hospital care plus supervised exercise starting within…

This study tested whether adding a second nerve block (rectus sheath block) to a standard chest wall block (pectointercostal fascial plane block) improves pain control after heart surgery. 62 adults having elective heart surgery through a breastbone incision were randomly assigne…

This study tested whether the sleep medication suvorexant (Belsomra) can help older adults sleep better and reduce confusion after heart surgery. One hundred patients aged 60 and older received either suvorexant or a placebo for seven nights in the ICU. Researchers measured sleep…

This study tested whether adding virtual reality (VR) driving simulations to standard cardiac rehabilitation helps heart surgery patients feel less anxious and depressed. Sixty adults recovering from heart surgery took part. The results suggest VR can improve emotional well-being…

This study tested whether Reiki (a light-touch energy therapy) and manual therapy (gentle massage) can improve recovery after open heart surgery. 272 patients were randomly assigned to receive either 20 minutes of these therapies for 3 days after surgery, or usual care with rest.…

This study tested whether electroacupuncture (using mild electric pulses through thin needles) can protect the heart and reduce inflammation in 104 people undergoing coronary artery bypass surgery. Researchers measured heart injury markers like troponin and inflammation levels. T…

This study explored how family members share health information about genetic diseases like sickle cell, diabetes, and cancer. Over 1,000 adults completed surveys or interviews about their family health history and support. The goal was to understand social and relational factors…

This study examined bleeding inside the heart muscle (intramyocardial hemorrhage) in 60 patients who had a severe type of heart attack called STEMI. Researchers compared two treatment strategies: giving clot-busting drugs followed by a procedure to open the artery, versus going s…

This completed study looked at how inflammation might connect heart disease and diabetes. Researchers used PET scans and blood tests to measure inflammation in 150 adults, including healthy volunteers. The goal was to better understand these links, not to test a new treatment.

This study looked at how two types of drug-coated heart stents (Orsiro and Resolute Integrity) heal inside the arteries of 50 people with stable heart disease. Researchers used a special camera to check the healing 4 months after the stents were placed. The goal was to see if one…

This study looked at 100 people with coronary artery disease who had a heart procedure through the wrist. Half got a short sheath and half got a long sheath. The goal was to see which one leads to fewer blockages in the radial artery. Researchers used ultrasound to check for bloc…

This study follows 200 adults who have elective coronary bypass or heart valve surgery to see how their physical abilities, lung function, and muscle strength change after the operation. Researchers measure walking speed, balance, handgrip strength, and breathing tests before and…

This study looked at whether using a very low flow of the anesthesia gas sevoflurane during heart surgery is safe and reduces environmental impact. 92 adults having planned heart surgery were randomly assigned to receive either ultra-low-flow or normal-flow anesthesia. Researcher…

This completed study looked at whether four easy-to-use nutrition scoring tools (GNRI, MNA-SF, PNI, and NAF) can predict serious lung complications after heart surgery in 217 patients aged 60 and older. Researchers tracked problems like pneumonia, blood clots in the lungs, and ne…

This study looked at 250 adults with stable coronary artery disease to see if feeling empowered and having a sense of purpose (called 'ikigai' in Japanese) are connected. Researchers used surveys to measure these feelings and how they relate to each other. The goal is to help nur…

This pilot study tested whether giving inhaled nitric oxide gas during laparoscopic surgery could protect blood vessels and organs in 40 adults with heart disease. Half received the gas through their breathing tube during surgery, and half received standard care. Researchers meas…

This study looked at whether a quick bedside test (Hemochron Jr) gives the same results as standard lab tests for measuring blood clotting in people having planned heart bypass surgery. Twenty patients were tested before and after being placed on a heart-lung machine. The goal wa…

This study tested a new X-ray-based imaging tool called 3DStent against the standard IVUS method to measure calcium buildup in heart arteries. Thirty adults with coronary lesions were enrolled. The goal was to see if 3DStent can accurately identify and measure calcium deposits, w…

This completed study observed 528 adults who had heart surgery and were admitted to the intensive care unit (ICU). Researchers tracked deaths, serious complications like stroke or infection, and patient details to identify risk factors. The goal is to use this information to impr…

This study tested whether specially designed educational videos, sent through a mobile messaging app, could help people with coronary heart disease improve their fitness and heart health knowledge during a 12-week home-based cardiac rehabilitation program. Twenty-one participants…

This study looked at 49 adults aged 30-65 who had a first heart attack about 4 months earlier. Researchers used brain scans to see if changes in the brain's blood vessels or structure are linked to memory or thinking problems. The goal is to better understand these issues and hel…

This study looked at damage to the protective lining of blood vessels during heart bypass surgery. Researchers measured a substance called syndecan-1 in the blood of 147 patients to see when and why this damage happens. The goal was to understand how surgery affects the body and …

This study looked at 150 Caribbean Hispanic adults with heart disease or stroke risk who take the blood thinner clopidogrel. Researchers wanted to see if certain gene variants affect how well the drug works. The goal is to understand why some people get less benefit and to pave t…

This completed study looked at 1000 people who had a coronary stent placed to see if a score based on insulin resistance could predict whether the stent would narrow again (restenosis). Researchers measured insulin resistance using routine blood tests and checked for restenosis w…

This completed study looked at how rising temperatures affect people with chronic conditions like heart disease, diabetes, and depression. Researchers in Germany and Italy surveyed 176 patients to see what symptoms they experienced during heat and what protective steps they took.…

This study looked at how a sedative called dexmedetomidine affects heart function during off-pump coronary artery bypass surgery. Researchers used ultrasound to measure heart pumping ability in 36 patients with coronary artery disease. The goal was to see if this medication helps…

This study checked how well over 5,000 heart patients follow their prescribed medicine routine. Researchers asked patients about their medication habits and any side effects. The goal was to understand how many patients do not take their medicines as directed.

This completed study looked at whether stomach emptying is slower during a heart attack, which could delay the absorption of crucial antiplatelet drugs. Researchers measured paracetamol levels in the blood every 15 minutes in 23 participants to track stomach emptying. The goal wa…

This study tracked 555 adults hospitalized with acute coronary syndrome (a serious heart condition) to see how quickly they called for help and what factors influenced their recovery. Researchers focused on delays in calling an ambulance and how those delays affected short- and l…

This pilot study looked at whether adding genetic risk information to standard heart disease counseling or health coaching helps people make healthier choices. 31 adults at risk for heart disease participated. The goal was to see if this approach is practical and can improve diet…

This pilot study tested whether drinking beet juice twice daily for two weeks could improve blood vessel function and breathing muscle strength in older adults with coronary artery disease. Eight participants were randomly assigned to receive either nitrate-rich beet juice or a p…

This study looked at 81 patients who had coronary artery bypass surgery to find out what factors affect how long they need a breathing tube afterward. Researchers checked things that happened before, during, and after surgery. The goal was to better understand what influences rec…

This study looked at over 3,300 people having a heart procedure through the wrist artery. Doctors tested different types of introducers (the tube used to access the artery) to see if a smaller size or a special coating could lower the risk of problems like artery blockage or spas…

This study looked at whether using a heart ultrasound probe (TEE) during low-risk coronary artery bypass surgery should be done routinely or only when needed. Researchers enrolled 40 patients and checked if it was possible to randomly assign them to one of two groups. The goal is…

This completed study looked at 76 people having heart bypass surgery. It tested two different ways of managing the pressure in the breathing tube during the procedure to see if it affected swelling in the airway. The goal was to find a safer pressure level to reduce complications…

This completed study followed over 7,200 heart patients in Tunisia to see how well they stick to their heart medications after a heart attack or procedure. Researchers simply observed and recorded data without giving any new treatment. The goal is to understand real-world medicat…

This study aimed to make heart rate monitors more accurate for people with heart conditions. Researchers collected data from 138 participants, including cardiac patients and athletes, using Fitbit and Polar devices over 13 weeks. The goal was to remove false readings and develop …

This study checked if certain blood markers can predict serious heart events like heart attack or death within a year after a stent procedure. Researchers measured two types of cells related to blood vessel health in 170 adults scheduled for a stent. The goal was to see if these …

This study tested whether a family history app can help doctors collect and use information about patients' family health risks. Over 600 adults aged 30-69 took part. The goal was to see if the app leads to better screening and genetic referrals for conditions like cancer, heart …

This study tested how well an Apple Watch measures heart and fitness data compared to standard medical equipment. About 50 adults with heart conditions or athletes wore the watch during exercise. The goal was to see if smartwatches can reliably help monitor heart disease.

This study tested how easy and acceptable the P-STEP mobile app is for people with chronic conditions like asthma, COPD, heart disease, or diabetes. 178 adults in Leicester, UK used the app for 12 weeks to track their walking and get air quality updates. The main goal was to meas…

This completed study tested whether a telehealth program, including a heart monitor and regular phone check-ins, could reduce symptoms and improve self-care and quality of life in 160 adults who had coronary artery bypass surgery. Participants were randomly assigned to either the…

This study looked at data from 100 patients who had heart artery imaging and pressure measurements. Researchers developed a new computer algorithm to analyze ultrasound images of the arteries and estimate how much they block blood flow. The goal was to see if the algorithm could …

This completed registry followed over 17,000 Korean patients with coronary artery disease who received drug-eluting stents. Researchers compared several types of stents to see which ones work best and are safest over the long term in everyday medical practice. The goal is to prov…

This study tested a program where doctors refer inactive people with chronic diseases (like diabetes, heart disease, or obesity) to an exercise professional for personalized counseling. The goal was to see if this referral scheme helps people become more active compared to just g…

This completed study looked at how much radiation people receive during heart CT scans (CCTA) in everyday hospital practice. Researchers enrolled 66 adults who needed a heart CT and recorded the radiation dose used, along with any dose-saving techniques. The goal was to understan…

This study looked at 233 people with heart or blood vessel disease who had calcium buildup in their heart arteries found by chance on a chest CT scan. Researchers wanted to see if telling both the patient and their doctor about this finding would encourage them to start cholester…

This study looked at 150 people with coronary artery disease who had bypass surgery, comparing those with and without diabetes. Researchers measured the fat around the heart (epicardial fat) and checked how it relates to death and heart problems after surgery. They also tested if…

This study tested a new imaging catheter (a thin tube with a camera) used during heart procedures to take pictures of the coronary arteries. 34 adults who were already scheduled for a heart catheterization or stent procedure took part. The goal was to see how easy the catheter wa…

This study checked whether the Turkish version of the Cardiac Depression Scale (CDS) works well for people with heart disease. Researchers tested 360 Turkish adults with various heart conditions to see if the scale accurately measures depression. The goal is to give doctors a rel…

This study looked at 100 people who had a heart attack to see if certain inflammation markers in the blood could predict who might die or develop heart failure within 6 months. Researchers measured these markers at several time points after the attack. The goal was to better unde…

This study looked at how a nerve condition called cardiovascular autonomic neuropathy (CAN) affects the risk of kidney injury in people having heart bypass surgery. Researchers tracked 912 adults before, during, and after surgery to see if those with CAN had worse kidney function…

This completed study looked at 400 people with both heart disease and a mental health condition (like depression or anxiety). Researchers used questionnaires, blood tests, and imaging to find shared risk factors and biological markers. The goal was to better understand how these …

This study looked at 70 adults having open heart surgery (aortic valve or bypass). It compared a newer, smaller heart-lung machine to the standard one. The goal was to see which method better protects the body's tissues and the brain during surgery. Results will help doctors choo…

This study looked at 60 heart surgery patients to see how two different bypass machines affect blood flow in tiny vessels under the tongue. One method was minimally invasive, the other was the standard approach. The goal was to find out which technique keeps small blood vessels w…

This study tested an AI system that reads medical records of 308 heart disease patients and pulls out key information like test results and diagnosis types. The AI's accuracy was compared to that of seven doctors. The goal was to see if AI can help make clinical data collection f…

This study looked at 150 older adults (75+) getting a new heart valve. It compared using a CT scan versus an invasive angiogram to check for blocked arteries beforehand. The goal was to see if the CT scan alone is safe and works just as well, potentially simplifying the process.

This completed study in Syria examined whether certain genetic variations in the apelin system are linked to coronary artery disease and high blood pressure. Researchers analyzed blood samples from 223 participants, including healthy controls and patients with heart disease and h…

This study looked at whether wearing an activity monitor (like a Fitbit) after heart surgery helps patients get moving sooner and return to their normal activity levels faster. Researchers tracked motivation, length of hospital stay, and readmission rates in 12 adults who had car…

This study tested whether a 12-week mobile app program for heart rehab is practical and liked by patients with coronary heart disease. 34 adults used the app after leaving the hospital, and researchers tracked how many signed up, used the app, and stayed in the program. The goal …

This study followed 318 people with suspected coronary artery disease for about 10 years to see whether starting with a CT scan or an invasive angiogram leads to better long-term outcomes. Participants had already completed an earlier study and agreed to additional follow-up, inc…

This study looked at 90 people with low or medium heart risk to see if tiny, non-blocking plaques in the heart arteries affect how blood clots and how blood vessels work. Participants had a special CT scan to find these small plaques, and their blood was tested for clotting activ…

This study looked at two different methods used to protect the heart during coronary artery bypass surgery. Twenty patients were randomly assigned to receive either Calafiore or modified Del Nido cardioplegic solutions. Researchers measured heart muscle damage markers and amino a…

This study looked at whether using low tidal volume (gentle) ventilation during heart-lung bypass surgery helps preserve diaphragm movement and reduce lung problems after surgery. Sixty adults having elective coronary artery bypass surgery were randomly assigned to receive either…

This study looked at 191 women with non-obstructive coronary artery disease (plaque that doesn't block arteries). Researchers used CT scans to measure whether intensive medical therapy (like statins and blood pressure drugs) reduced plaque more than usual care. The goal was to se…

This study looked at 55 adults having beating-heart coronary bypass surgery. Doctors compared a standard ultrasound method (TEE) with a less invasive monitor that uses the arterial line to see how well each predicted the need for extra fluids. The goal was to see if the simpler d…

This completed study looked at 294 patients who had a procedure to open a completely blocked heart artery (CTO PCI) with a drug-coated stent. Researchers wanted to know how often the stents narrowed again over at least three years and what factors increased that risk. The study u…

This study looked at 80 people who had a heart attack but no major blockages in their heart arteries (called MINOCA). Researchers checked if the ratio of white blood cells to a platelet marker in their blood could predict short-term health outcomes. The goal was to see if this si…

This study reviewed records of 65 heart disease patients who completed a structured exercise program. Researchers compared their fitness, depression levels, quality of life, and sleep quality before and after rehab. The goal was to see if the program helped improve these areas. B…

This study tested whether special communication training for pharmacists and general practitioners helps them involve older patients in decisions to stop or lower medications for heart disease and diabetes. Researchers enrolled 310 patients aged 75 and older who were taking certa…

This study looked at whether using very small breaths (ultra-low tidal volume) during heart bypass surgery can reduce stress on the lungs and help patients recover faster. Sixty adults having planned bypass surgery were randomly assigned to receive either this gentle breathing me…

This study looked at two ways to manage breathing during heart surgery that requires one lung to be deflated. Researchers compared using a double-lumen tube versus a bronchial blocker in 66 patients. They checked for lung problems after surgery, how long it took to place the devi…

This study tested whether a theory-based motivational letter mailed six months in advance could increase attendance at a one-year post-cardiac rehabilitation check-up. Researchers compared 102 adults who received the letter to those who got usual care. The goal was to see if a si…

This study looked at 552 people hospitalized with acute coronary syndrome, a serious heart condition. Researchers calculated a value called the leukoglycemic index (LGI) from routine blood tests and compared it to the SYNTAX score, which measures how complex the coronary artery d…

This study looked at whether notifying patients and their doctors about calcium found in the heart arteries on a routine chest CT scan would lead to more people starting statin medications. Researchers enrolled 202 adults who had this incidental finding and randomly assigned them…

This study looked at 485 patients who had coronary artery bypass surgery to see if a computer method called fuzzy logic could better predict who is at risk of dying. Fuzzy logic is a way to handle uncertain information, similar to how doctors think. The goal is to create a tool t…

This study tested a new combination of very low-dose aspirin (20 mg twice daily) plus a blood thinner called rivaroxaban (2.5 mg twice daily) in 48 adults with chronic coronary syndromes. Researchers compared this new regimen to standard aspirin alone (75 mg once daily) and stand…

This completed study with 50 adults undergoing coronary bypass surgery tested whether a neck ultrasound (corrected carotid flow time) and a simple leg-raising maneuver can reliably show if a patient needs more fluids. The goal was to find a non-invasive alternative to standard in…

This study looked at how long people who had a heart attack should take two blood-thinning medicines (aspirin plus a second drug). About 5,000 patients were randomly assigned to shorter or longer treatment. The goal was to find the best balance between preventing another heart at…

This study tested two different solutions used to protect the heart during coronary artery bypass surgery. Forty adults having non-emergency bypass surgery took part. Researchers measured heart enzyme levels and other recovery signs in the first two days after surgery to see whic…

This study looked at how doctors in the U.S. manage blood thinners in heart patients who need surgery. The goal was to understand the risks of bleeding and clotting with different approaches. 147 patients were observed to gather data for future research. No new treatments were te…

This study looked at whether the time of day a person has heart surgery changes how their heart muscle tolerates the stress of the procedure. Researchers took small tissue samples from the hearts of 88 patients having planned heart surgery, either in the morning or afternoon. The…

This completed observational study looked at 43 patients with stable coronary artery disease who had balloon angioplasty. Researchers measured blood flow (fractional flow reserve) right after the procedure and compared it with angiographic images. They also compared two types of …

This study looked at 78 adults who had heart surgery and needed a breathing tube while being moved to the intensive care unit. Researchers compared using a manual bag (AMBU bag) versus a mechanical ventilator (Hamilton C1) to see which method kept blood pressure and oxygen levels…

This study tested a short, fast step-climbing exercise in 44 people with coronary artery disease to see if it is safe and useful for measuring anaerobic fitness. Participants stepped up and down a 17.5 cm step for one minute while heart rate and pain were monitored. The goal is t…

This study tested whether monitoring the pupil's reaction to light (pupillometry) can help doctors give less opioid pain medicine during heart surgery. Fifty adults having coronary artery bypass surgery took part. The goal was to see if using pupillometry to guide pain medicine d…

This study looked at how Chinese Americans talk about advance care planning—decisions about end-of-life care—with their families. Researchers interviewed religious leaders, patients with chronic diseases, and family caregivers in Chicago to understand their needs and readiness. T…

This study looked at whether continuously measuring oxygen levels in the brain during heart bypass surgery can reduce memory and thinking problems after the operation. 326 older adults (age 60+) having planned heart surgery took part. Researchers compared standard care to care gu…

This study looked at 1,695 people with stable heart disease affecting multiple arteries. Researchers compared long-term outcomes for those who had bypass surgery, stents, or took medication only. The goal was to see which approach best prevents heart attacks and heart-related dea…

This study looked at whether nitrous oxide (laughing gas) is safe for people with heart disease risk factors who need major surgery. Over 7,000 adults aged 45 and older were randomly assigned to receive either nitrous oxide or a gas without it during anesthesia. The researchers t…

This study tested if the exact spot where a needle enters the wrist affects the chance of a painful artery spasm during a heart catheterization. 380 adults were randomly assigned to have the puncture either very close to the wrist bone or a bit farther away. The goal was to find …

This completed study tested whether artificial intelligence could analyze CT scans of the heart to better predict who is at risk for heart attacks or death. Researchers looked at data from 2190 patients with coronary artery disease. The goal was to create a risk score that goes b…

This study looked at whether artificial intelligence (AI) can help predict the risk of heart attacks in people with early signs of heart disease. Researchers analyzed heart scans and health data from 3000 patients. The goal was to find a better way to identify who needs more aggr…

This study looked at 129 patients who had surgery to clear blocked neck arteries, a common cause of stroke. Doctors compared two surgical techniques—the eversion method and the conventional method—to see which had fewer complications like stroke or artery re-blockage within 30 da…

This completed study enrolled 100 adults who were already scheduled for a cardiac CT scan for clinical reasons. Researchers wanted to see how well the scans could help diagnose coronary artery disease and predict future heart problems. They also looked at the balance between bene…

This study looked at how a patient's age, health history, and other factors affect brain oxygen levels during coronary artery bypass surgery. Researchers measured brain oxygen using a special light-based device in 80 adults aged 25-80. The goal was to better understand what influ…

This completed study looked at 160 people with coronary artery disease who needed a stent in one artery and also had a partial blockage in another. Researchers measured pressure in the second blockage before and after stenting the first, to see if treatment changed the reading. T…

This study looked at how many coronary artery bypass surgeries a surgical resident needs to perform to become skilled at using two imaging tools: transit-time flowmetry and high-frequency ultrasound. These tools help check the quality of the new blood vessels during surgery. The …

This study looked at people with blocked heart arteries that have side branches. Doctors placed a stent in the main artery but did not always open the side branch if blood flow was acceptable. The goal was to see if opening the side branch caused more harm or benefit. About 477 p…

This study looked at how well a special heart MRI (called stress CMR) finds blocked arteries in real hospitals, not just research centers. Researchers tracked 2,349 people aged 35-85 who had symptoms of heart disease. They recorded heart attacks, deaths, and hospital visits to se…

This study looked at how well a daily low-dose aspirin works in people who have both immune thrombocytopenia (low platelets) and heart disease. Only 4 adults took part. Researchers measured platelet function after aspirin to see if the standard dose is enough to prevent blood clo…

This completed Phase 4 study looked at whether the blood thinner argatroban causes heart rhythm changes (QTc prolongation) in 50 patients with stable coronary artery disease or unstable angina during angioplasty. Patients received argatroban by IV and had ECGs before and after th…

This study tested whether a systematic phone call from a medical student, supervised by a general practitioner, could reduce hospitalizations in patients with chronic heart or mental health conditions during the COVID-19 lockdown in France. Over 22,000 patients aged 70 and older …

This study looked at 320 adults who had heart surgery to see how well two different risk scores (EuroSCORE-II and POSPOM) predict the chance of dying in the hospital. Researchers calculated each patient's scores before surgery and compared them to what actually happened. The goal…

This study gathered information from about 2,700 people with coronary artery disease who had a special imaging test called Optical Coherence Tomography (OCT) during a heart procedure. Researchers followed participants for up to 5 years to track major heart problems. The goal was …

This study combined data from over 1,700 patients who had a heart attack or unstable angina and underwent a special imaging test (OCT) of their heart arteries. Researchers aimed to find factors that predict plaque erosion, a common cause of heart attacks. The goal is to better un…

This study followed 4000 people who received a XIENCE Xpedition, Alpine, or Sierra stent to open blocked heart arteries. Researchers tracked deaths, heart attacks, and repeat procedures to see how safe and effective these stents are in routine care. The goal was to gather real-wo…

This study looked at whether orienteering (a navigation-based walk) is as good as regular walking for heart rehab. 40 people with stable heart disease took part. Researchers measured heart rate and enjoyment during both activities. The goal was to see if orienteering could be a f…

This study checked how well 109 heart attack survivors in Nepal took their prescribed medicines and what made it hard for them. Researchers used a simple questionnaire to find out. The goal is to help doctors and patients improve medicine-taking habits and prevent future heart pr…

This study looked at whether a 6-minute stepper test (ST6) can accurately measure exercise tolerance in people with heart conditions undergoing rehabilitation. Researchers compared the stepper test results with the standard 6-minute walk test and a cardiac stress test in 60 patie…

This study tested whether a new questionnaire, the BETY-Biopsychosocial Questionnaire, accurately measures the overall well-being of people with coronary artery disease. Researchers enrolled 100 adults aged 18-80 with heart disease to complete the questionnaire and compare it wit…

This completed study looked at 175 people with both coronary heart disease and depression. Researchers measured depression severity and heart risk markers to understand which symptoms, like fatigue and loss of interest, might be linked to worse heart outcomes. The goal is to find…

This study looked at whether a non-invasive eye scan (OCTA) can predict how well blood flows in the heart's small arteries. Researchers examined 101 people with coronary artery disease, comparing eye images to measurements taken during heart catheterization. The goal was to see i…

This study looked at 1,655 people who had a heart attack or unstable angina (acute coronary syndrome) to create a personalized risk model. Researchers used medical tests, genetic information, and other health data to predict who might have worse outcomes or complications from tre…

This completed registry study followed 500 Chinese patients who received the Agent DCB, a paclitaxel-coated balloon catheter, during a heart procedure to open blocked arteries. The goal was to collect real-world data on heart-related events like heart attacks or repeat procedures…

This completed study looked at whether patients hospitalized for a heart attack, stroke, or other cardiovascular event received the right medications to prevent future problems. Researchers reviewed records of 129 patients to see if doctors prescribed cholesterol-lowering drugs a…

This study looked at 10,000 people who came to the emergency room with chest pain. Researchers tested new blood markers to see if they could diagnose heart attacks faster than current methods. The goal is to help doctors quickly rule out or confirm a heart attack, especially in t…

This study looked at 1,586 heart attack patients who had multiple blocked arteries. After opening the main blockage, doctors compared doing a second procedure to fix the other blockages either early (within a few days) or later (weeks after). The goal was to see which timing bett…

This study looked at 2000 adults with early heart disease to understand how inherited high cholesterol (familial dyslipidemia) contributes to heart attacks. Researchers reviewed medical records to find patterns in cholesterol levels. The goal was to highlight the need for better …

This completed study in Egypt examined 1,000 adults with heart disease to see how many reached their LDL cholesterol targets and what got in the way. Participants provided a fasting lipid profile, and researchers looked for patterns and barriers. The goal is to find better ways t…

This study looked at 514 people with stable coronary artery disease to see if how their body processes fat after a meal (triglyceride tolerance) is linked to future heart attacks or death. Researchers also checked blood sugar tolerance. The goal was to find a better way to identi…

This study looked at 348 people who had open heart surgery with a heart-lung machine. Researchers wanted to see if the ratio of time on the machine to time the heart was stopped affected complications or death. The goal is to find a better way to predict and improve recovery afte…

This study looked at whether using a thin, 7-French sheath through a small artery in the wrist is safe and effective for opening blocked heart arteries. 100 adults with heart disease took part. The goal was to see if this approach causes fewer bleeding or artery problems while st…

This study analyzed health records from over 400,000 adults who had heart surgery to see if the sedative dexmedetomidine helped prevent problems like confusion, kidney injury, or death within 30 days. Researchers compared patients who received the drug around surgery time to thos…

This study looked at how many girls and young women aged 11 to 20 with chronic diseases (like diabetes or immune conditions) got the HPV vaccine, compared to those without chronic illness. Researchers reviewed records of 223 participants from a hospital in France. The goal was to…

This study examined how immune cells change in people with coronary atherosclerosis (hardening of the arteries). Researchers compared blood and heart tissue samples from 61 patients undergoing heart surgery—some with coronary artery disease and some without. The goal was to see i…

This study compared radiation exposure to doctors during heart procedures (coronary angiography and stenting) using two different arm artery approaches: the left distal radial artery and the conventional right radial artery. Over 1,000 patients participated. The goal was to see i…

This study looked at the gut bacteria and bile acids of 80 people — half with coronary artery disease and half healthy. Researchers wanted to see if differences in these gut factors might be linked to heart disease. The goal is to better understand how the gut influences heart he…

This study looked at 48 older adults having heart bypass surgery to see if a small molecule called microRNA-151-5p is linked to memory and thinking problems after the operation. Researchers measured levels of this molecule and inflammation in the blood before and after surgery, a…

This study tested an indoor air pollution intervention called AIRWISE in 20 adults aged 55 and older with heart disease. Participants received personal air cleaners, a color-changing air quality monitor, and educational materials. The goal was to see if they would use these tools…

This study looked at whether silent myocardial ischemia (reduced blood flow to the heart without chest pain) increases the risk of heart problems or death in people with coronary heart disease. Researchers followed participants for one to three years. The goal was to better under…

This study looked back at over 2,300 people with known or suspected heart disease who had a stress cardiac MRI. Researchers wanted to see if certain MRI findings could predict future heart attacks or death from heart disease. The goal is to better understand how these scans can h…

This study involved 150 people with completely blocked heart arteries who had a special procedure called STAR. Researchers wanted to find the best time to place a stent afterward—either 5-7 weeks or 12-14 weeks later. The goal was to see which timing leads to a more successful st…

This study followed 750 people with severe coronary artery disease who were not eligible for bypass surgery. Researchers tracked survival at 30 days and quality of life at 12 months after less invasive procedures or medical therapy alone. The goal was to understand real-world out…

This completed study tested whether healthcare claims data can predict the results of a major heart trial (SURPASS-CVOT) comparing two diabetes drugs, tirzepatide and dulaglutide. Researchers analyzed records from over 44,000 people with type 2 diabetes and heart disease to see i…

This study looked at 100 patients with aortic valve sclerosis (a stiffening of the heart valve) and chest pain to see if a blood fat called lipoprotein(a) is linked to the severity of blocked heart arteries. Researchers measured Lp(a) levels from blood samples and compared them t…

This study looked back at 51 patients with widened or bulging coronary arteries to see which blood-thinning medications they were prescribed and how those treatments affected their risk of heart attacks, strokes, or bleeding. Researchers reviewed records from a single hospital ov…

This study tested a strategy to decide which patients need additional artery-opening treatment after a TAVI heart valve procedure. Researchers used a special imaging scan (SPECT) to look for areas of the heart not getting enough blood. The goal was to see if this imaging-guided a…

This study looked at 135 adults having off-pump coronary artery bypass surgery to see if vitamin D levels affect hemoglobin (a protein in red blood cells) recovery after surgery. Researchers measured vitamin D and a hormone called hepcidin, which controls iron use. The goal was t…

This study looked at 28 people with both stable coronary artery disease and moderate sleep apnea. Researchers measured blood markers of oxidative stress (a type of cell damage) before and after 3 months of CPAP therapy. The goal was to see if CPAP could reduce oxidative stress, w…

This study tested whether rotigaptide, a drug that improves cell communication, can protect blood vessel function after a temporary blockage of blood flow (ischemia-reperfusion injury). Twelve healthy men received the drug or a placebo while their forearm blood flow was measured.…

This study used cardiac CT scans to compare the amount of high-risk plaque in the coronary arteries of 480 people with and without a family history of coronary artery disease. All participants had no prior heart problems. The goal was to see if those with a family history have mo…

This completed study looked at 258 people with different types of cardiomyopathy (a disease of the heart muscle) to see if special imaging could predict stroke risk. Researchers used echocardiograms and MRI scans to measure blood flow in the heart and check for silent brain infar…

This study monitored brain oxygen levels and electrical activity in 15 children aged 6 to 36 months during open heart surgery. Sensors placed on the forehead measured oxygen and brain waves every 5 minutes. The goal was to understand how these measurements relate to each other, w…

This study looked at two ways to assign care coordinators to older adults (65+) with heart disease or risk factors. One method used patients' own reports of difficulty coordinating care, while the other used usual triggers like hospital discharge. The goal was to see which approa…

This study looked at 116 patients with severe aortic stenosis and moderate coronary artery disease who were scheduled for valve replacement. Researchers measured blood flow in the heart arteries before, right after, and 6 months after valve replacement to see how the procedure af…