Heart stent showdown: ultrasound guidance may beat standard X-Ray for major artery blockage

NCT ID NCT04111770

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether using ultrasound inside the heart arteries (IVUS) to guide stent placement works better than standard X-ray guidance for people with a blockage in the left main coronary artery. About 800 patients were randomly assigned to one of the two methods and followed for up to 2 years. The goal was to see which approach reduces the risk of death, stroke, heart attack, or the need for another procedure.

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Conditions

The condition(s) this trial relates to.

coronary stenosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • A.O.U. di Ferrara

    Ferrara, Italy

  • AOUI Verona

    Verona, Italy

  • ASST Niguarda

    Milan, Italy

  • ASST Papa Giovanni XXIII

    Bergamo, Italy

  • Bristol Royal infirmary

    Bristol, United Kingdom

  • Golden Jubilee National Hospital

    Clydebank, United Kingdom

  • Hospital Alvaro Cunqueiro

    Vigo, Spain

  • Hospital Clinico Lozano Blesa

    Zaragoza, Spain

  • Hospital Clinico San Carlos

    Madrid, Spain

  • Hospital Clinico Universiatrio V. Arrixaca

    Murcia, Spain

  • Hospital Reina Sofia

    Córdoba, Spain

  • Hospital Universitario Marqués de Valdecilla

    Santander, Spain

  • Hospital Universitario de A Coruña

    A Coruña, Spain

  • Hospital Vall d´Hebron

    Barcelona, Spain

  • Hospital de Bellvitge

    Barcelona, Spain

  • Hospital de Cabueñes

    Gijón, Spain

  • Interventistica Cardiologica Strutturale

    Florence, Italy

  • John Radcliffe Hospital

    Oxford, United Kingdom

  • Leeds General Infirmary

    Leeds, United Kingdom

  • Policlinco San Donato

    Milan, Italy

  • Policlinico Umberto I

    Rome, Italy

  • Royal Bournemouth Hospital

    Bournemouth, United Kingdom

  • Royal Sussex Country Hospital

    Brighton, United Kingdom

  • Royal Victoria Hospital

    Belfast, United Kingdom

  • Sant'Ambrogio Clinical Institute

    Milan, Italy

  • St Bartholomew's Hospital

    London, United Kingdom

  • The Freeman Hospital

    Newcastle upon Tyne, United Kingdom

  • University Hospital of Wales

    Cardiff, United Kingdom