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Heart scan study: family history may reveal hidden plaque risk

NCT ID NCT07172308

Knowledge-focused Sponsor: I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study used cardiac CT scans to compare the amount of high-risk plaque in the coronary arteries of 480 people with and without a family history of coronary artery disease. All participants had no prior heart problems. The goal was to see if those with a family history have more dangerous plaque, which could help guide earlier prevention.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If it shows more high-risk plaque in those with a family history, it could support using heart CT scans for earlier prevention in that group.
What could go wrong
This is a small, completed observational study, not a treatment trial. It only looks at images, not future heart attacks, so the real benefit is uncertain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

480 people

The number who actually took part.

Started

Jan 2025

Finished

Aug 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

History of any adverse reaction to contrast medium * History of any severe allergic reactions * Previous history of chronic kidney disease (eGFR\<30 ml/min/1.73m2) * Previous history of cardiovascular disease, including documented asymptomatic atherosclerosis

Ages

40 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Group 1 * Patients with clinical indation to CCTA for suspected CAD with family history of CAD * Age \>40 years old for male and \>50 years old for female * No history of previous cardiovascular disease Group 2 * Patients with clinical indation to CCTA for suspected CAD without family history of CAD * Age \>40 years old for male and \>50 years old for female * No history of previous cardiovascular disease

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Conditions

The condition(s) this trial relates to.

coronary artery disorder coronary atherosclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Atherosclerosis of coronary artery Coronary artery disease (CAD)

Contacts and locations

Locations

  • IRCCS Ospedale Galeazzi-Sant'Ambrogio

    Milan, Italy

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