Coronary artery disorder

This study tests whether using a temporary heart pump (CorVad) during a procedure to open blocked arteries (PCI) can improve outcomes for people with complex coronary artery disease and a very weak heart (ejection fraction below 35%). Half of the 452 participants will receive the…

This trial compares a new temporary heart pump called VentriCure with standard ECMO support in people with coronary artery disease undergoing high-risk angioplasty. The study includes 220 patients whose hearts are weak or who have severe heart failure. The goal is to see if Ventr…

This early-stage study tests whether it is safe to take nitroglycerin spray (used for chest pain) together with an experimental drug called nurandociguat (designed to help kidneys) in 36 adults with stable coronary artery disease. Both drugs widen blood vessels, so the main conce…

This study tests whether mazdutide, a weekly injection that helps with weight loss, can slow the buildup of fatty plaque in the heart arteries of 116 overweight or obese adults with coronary heart disease. Participants will receive either the drug or a placebo for 52 weeks, and d…

This trial tests whether a specialized scoring balloon, called Naviscore, can better prepare calcified coronary arteries before placing a drug-eluting stent. Hardened plaques often prevent stents from expanding fully, raising risks of re-narrowing or clots. About 200 adults with …

This study looks at whether icosapent ethyl, a purified fish oil medication, can reduce inflammation and improve heart structure in people with coronary artery disease. Researchers will follow 420 patients for one year, comparing those who receive standard care plus icosapent eth…

This study looks at how a special balloon called the OPN balloon is used to open severely hardened or blocked heart arteries. Researchers will track 300 adults who need this procedure to see how well it works and what problems might happen. The goal is to learn the best ways to u…

This study compares a moderate statin (pitavastatin) combined with ezetimibe against high-intensity statins (atorvastatin or rosuvastatin) in patients aged 75+ with coronary artery disease who need a stent. The goal is to see if the combo is just as good at preventing heart attac…

This study looks at a special stent (a small mesh tube) coated with a drug called sirolimus, used to open blocked heart arteries. Researchers will follow 300 adults who received this stent during a standard heart procedure to see how safe and effective it is over 5 years. The mai…

This study tests whether using a computer simulation (virtual stenting) before placing stents in heart arteries can lead to better outcomes than the usual method guided by X-ray images alone. About 1,472 adults with coronary artery disease will be randomly assigned to either the …

This study tests whether customizing ventilator settings during heart bypass surgery can lower the risk of lung complications like pneumonia or respiratory failure. Researchers will compare a standard approach with one that adjusts settings based on lung mechanics. Eighty adults …

This study compares two supervised treadmill exercise programs for people recovering from coronary artery disease or a heart procedure. One group does high-intensity interval training (HIIT) — short, hard efforts with rest periods — while the other does moderate-intensity continu…

This study tests whether adding a Chinese herbal medicine called Qidan Xiaoke Granules to standard heart drugs can reduce major heart problems like heart attacks or repeat procedures in people who have had a stent placed. About 164 adults with coronary artery disease will take th…

This study will compare a newer, less invasive heart procedure called hybrid revascularization to standard coronary artery bypass grafting (CABG) in over 1,000 people with multiple blocked heart arteries. The hybrid approach combines a small incision to graft a key artery with st…

This study compares two approaches for people with heart failure and narrowed heart arteries: a stent procedure plus guideline-directed medications versus medications alone. About 1,150 participants will be followed for at least two years to see which group has fewer major heart …

This study tests whether Baduanjin, a gentle traditional Chinese exercise, helps people recover after heart bypass or stent surgery. Researchers will track 310 adults for up to a year to see if it lowers the risk of heart attacks, chest pain, or the need for more procedures. The …

This pilot study tests two ways of running a temporary heart pump (Impella CP) during a high-risk procedure to open blocked heart arteries in patients with weakened heart muscle. Fifty patients will be randomly assigned to either an automatic mode that adjusts flow or a fixed low…

This study tests a procedure called renal denervation, which uses a catheter to calm overactive nerves in the kidneys, in 1,000 people with both resistant hypertension and multivessel coronary artery disease. Participants will undergo the procedure during a planned heart stent op…

This study tests whether a new wire-free imaging method called μFR can help doctors decide which blocked heart arteries need stents after a heart attack. About 350 patients with multiple blocked arteries will be randomly assigned to standard care or μFR-guided treatment. The goal…

This study will test whether taking ginger supplements for two months can lower inflammation and oxidative stress in people with coronary artery disease. Fifty adults with confirmed heart disease will be randomly assigned to receive either ginger extract or a placebo. Researchers…

This study looks at whether taking royal jelly and propolis (natural bee products) for two months can lower inflammation and improve heart health in 50 adults with coronary artery disease. Participants will be randomly assigned to receive the supplements or a placebo, and researc…

This small pilot study will test a program where nurses and general practitioners help breast cancer survivors who also have heart disease make healthy lifestyle changes. The program includes exercise, diet changes, quitting smoking, and stress-reducing activities like yoga. The …

This study tests a new approach for women with chest pain who don't have blocked arteries. Doctors will use special tests to find the exact cause of the pain, then give each woman a personalized treatment plan. The goal is to see if this tailored approach improves symptoms and qu…

This study compares 1 month versus the standard 6 months of dual antiplatelet therapy (two blood thinners) in people who had a balloon procedure for small coronary artery disease. About 1,484 adults with stable angina or silent ischemia will be randomly assigned to either short o…

This study tests whether the drug vericiguat can prevent serious heart and organ problems in people undergoing heart surgery. About 600 high-risk patients will receive either vericiguat plus standard care or standard care alone. The goal is to see if vericiguat reduces early comp…

This study tests whether the drug propranolol can prevent heart injury after breast cancer surgery in women who also have high blood pressure or angina. One hundred participants will either receive propranolol before surgery or standard care. Researchers will measure heart stress…

This study tests whether adding Vitamin C, Omega-3 fatty acids, lignin, and lactulose to standard care can improve recovery in 108 adults after coronary artery bypass grafting (CABG). Participants will take the supplements daily for 10 weeks starting 15 days after surgery. The go…

This pilot study checks if a bigger trial on low-dose aspirin for people with early, symptom-free coronary artery disease can be done. It will enroll 48 adults with signs of artery narrowing but no symptoms. The main goal is to see if doctors can recruit enough patients and if pa…

This study compares a drug-coated balloon (DCB) to a drug-eluting stent (DES) for treating new blockages in heart arteries. About 1,548 adults with stable or unstable angina, old heart attacks, or silent ischemia will be randomly assigned to one of the two treatments. The main go…

This study tests a program called Moxie that sends weekly mail and a mobile app to help people with chronic heart, kidney, or diabetes conditions manage their health after a hospital stay. The goal is to see if it reduces the chance of going back to the hospital. About 9000 adult…

This study tests whether an early, aggressive approach—using a catheter to open and stent high-risk plaques seen on a CT scan—plus medication is better than medication alone for preventing heart problems. About 2,500 people with coronary artery disease will be randomly assigned t…

This study tests whether drinking a specially designed milk every day for a year can reduce the chance of stents narrowing again and prevent further heart problems in people who have had a first heart attack. About 140 adults who recently had a stent placed will be randomly assig…

This study compares a new stent that releases sirolimus and ascorbic acid (vitamin C) to a standard everolimus-releasing stent in over 2,000 people with coronary artery disease. The goal is to see if the new stent is as good at preventing heart-related complications like death, h…

This study tests whether TA-65, a dietary supplement that activates telomerase, can improve small blood vessel function in healthy older adults and people with coronary artery disease. Researchers will measure blood vessel responses and blood pressure in 180 participants. The goa…

This study tests if using only drug-coated balloons is as safe and effective as stenting for treating blocked heart arteries at branch points. About 272 people with chronic coronary syndrome will be randomly assigned to one of the two treatments. Researchers will track deaths, he…

This early study tests a special cap that shines near-infrared light on the heads of infants who have had a cardiac arrest in the hospital. The light is meant to reduce brain injury caused when blood flow returns. The trial will include 30 infants with heart disease and will chec…

This study looks at how long people should take a combination of two blood thinners (ticagrelor and aspirin) after coronary artery bypass surgery to keep the new vein grafts open. 300 patients will be randomly assigned to take the combination for 3, 6, or 12 months, then switch t…

This study tests whether a medicine given as a nose spray before a heart stent procedure can reduce heart muscle injury or heart attack. About 1800 adults scheduled for elective stent placement will receive either the medicine or a placebo spray. Researchers will measure heart da…

This study compares two surgical techniques for coronary artery bypass grafting (CABG). One uses only arteries (total arterial grafting), while the other uses a mix of artery and vein grafts (conventional mixed grafting). The goal is to see which approach keeps grafts open longer…

This study tests whether a drug-coated balloon (DCB) is as safe and effective as a drug-eluting stent (DES) for treating large blockages in heart arteries. About 2,492 patients will be randomly assigned to receive either a balloon or a stent, guided by advanced imaging. The goal …

This study tests a 3-month behavioral coaching program for 232 adults with coronary heart disease who sit a lot. The program includes face-to-face and phone sessions to help them reduce sitting time and increase physical activity. Researchers will measure changes using activity t…

This study will test if using artificial intelligence to find calcium buildup in heart arteries from chest CT scans people already had can improve cholesterol treatment. Researchers will notify patients and their doctors about the finding, aiming to start or strengthen cholestero…

This study tests whether a drug-coated balloon is as good as or better than a drug-eluting stent for people with multiple blocked heart arteries. About 892 adults with stable heart disease or recent heart attack will be randomly assigned to one of the two treatments. The goal is …

This trial tests a hybrid exercise program (HyBEST) for people with coronary artery disease. It combines supervised sessions at a center with home workouts using a wearable tracker. The goal is to see if this approach improves exercise capacity, body composition, and quality of l…

This study tests whether a smartphone app powered by artificial intelligence can help adults recover after heart surgery. 500 patients will either use the app plus standard care or standard care alone. The app gives personalized advice on medications, spotting complications early…

This study tests a new method for closing the breastbone after coronary artery bypass graft (CABG) surgery using special knotless barbed sutures and a skin adhesive. Researchers will compare 401 adults who receive this new closure to past patients who had standard closure. The go…

This study tests a drug called YN001 in 456 adults with coronary atherosclerosis (plaque buildup in heart arteries). Participants receive weekly injections of YN001 or a placebo for 13 weeks. The main goal is to see if YN001 reduces plaque volume in the arteries, as measured by a…

This study tests whether using a blood-pressure cuff device (called chronic remote ischemic conditioning) along with mindfulness audio sessions can improve blood flow to the heart in people with coronary artery disease who couldn't have all blockages opened. About 480 adults with…

This study tests a new device called the Shockwave C2 Aero, which uses sound waves to break up calcium deposits in heart arteries before placing a stent. About 200 people with coronary artery disease will be enrolled across 8 U.S. sites. The goal is to see if the device works saf…

This registry will follow 2000 people with complex coronary artery disease who receive the Inspiron EVO drug-eluting stent. The stent is designed to be easier to deliver and stronger than standard stents. Researchers will track how well the stent works and whether it reduces hear…

This study looks at whether people with atrial fibrillation who have had a successful heart ablation and also have a heart stent can safely stop taking blood thinners. Participants who maintain a normal heart rhythm for at least a year after ablation will either continue blood th…

This Phase 3 trial will test whether a combination of three cholesterol-lowering drugs—bempedoic acid, ezetimibe, and a high-intensity statin—can reduce and stabilize plaque buildup in the coronary arteries. The study enrolls 103 adults with coronary atherosclerosis who have neve…

This study tracks 1,200 people with coronary artery disease who receive a drug-coated balloon instead of a metal stent during angioplasty. The goal is to see if this approach reduces heart-related deaths, heart attacks, and the need for repeat procedures. Researchers hope to conf…

This study compares two methods to prepare severely calcified heart arteries before placing a stent: a shockwave device that breaks up calcium versus standard balloon treatment. It also tests whether using a special camera inside the artery or standard X-ray leads to better resul…

This study compares two treatments for coronary artery disease: a drug-coated balloon and a drug-eluting stent. It focuses on patients with high bleeding risk who need a simpler approach. Researchers will track heart attacks, strokes, and bleeding events to see which option is sa…

This study tests a special balloon that uses shockwaves to break up hardened calcium deposits in heart arteries. About 200 people with severe blockages will receive this treatment to see if it safely improves blood flow and reduces the risk of heart attack or death. The goal is t…

This study will screen 1,500 people with early signs of heart disease (plaque in arteries) to see if two common drugs—rosuvastatin and colchicine—can reduce or stabilize that plaque over two years. Participants will take pills daily and get heart-healthy lifestyle advice. The goa…

This study tests whether adding adenosine to the standard heart-protecting solution used during bypass surgery helps the heart recover better. Sixty adults having elective valve or bypass surgery will receive either adenosine or a placebo. Researchers will measure heart function,…

This study tests whether a special clinic where heart, kidney, diabetes, and liver doctors work together can help people with type 2 diabetes and heart disease get better control of their blood pressure and cholesterol. About 150 adults will be randomly assigned to either usual c…

This study compares two drugs, milrinone and epinephrine, to treat right heart dysfunction that can occur after cardiac surgery. The trial will enroll 102 adults undergoing heart surgery with a heart-lung machine. The goal is to see which drug better improves right heart function…

This study looks at 4,400 people who had a heart attack and got a stent. It tests two drug strategies: one to lower bleeding risk by adjusting blood thinners, and another to lower cholesterol using a milder statin plus ezetimibe. The goal is to find the safest and most effective …

This study reviews medical records of 252 patients who received a drug-coated balloon to treat blocked heart arteries. The goal is to see how safe and effective the balloon is over two years. Researchers will track heart-related deaths, heart attacks, and the need for repeat proc…

This pilot study tests whether taking a synbiotic supplement (a mix of probiotics and prebiotics) for 10 weeks can lower TMAO levels and improve other heart health markers in 80 adults who recently had a heart attack. The goal is to see if changing gut bacteria can help prevent f…

This study compares the safety of the drug flecainide against standard treatments (sotalol or amiodarone) in about 988 adults with atrial fibrillation and stable coronary artery disease. Participants will be randomly assigned to one treatment and followed for at least a year to t…

This study tests if using a drug-coated balloon along with a stent works better than a stent alone for people with complex blockages in the left main coronary artery. About 186 adults with this condition will be randomly assigned to one of two treatments. The goal is to see which…

This study tests whether a smartwatch, combined with artificial intelligence, can help monitor heart attack patients during their recovery at home. About 1,050 participants will either use the smartwatch with AI, a smartwatch without AI, or receive standard care. The goal is to s…

This study looks at whether people who had a heart procedure with a drug-coated balloon can safely stop taking antiplatelet drugs after 12 months. The goal is to see if stopping reduces bleeding risks while keeping the heart protected. About 1,000 adults who have been event-free …

This study compares two ways of preparing a re-narrowed heart artery before using a drug-coated balloon to open it. In 500 adults with in-stent restenosis, half will get standard balloon prep and half will get a more aggressive prep with special cutting or scoring balloons. The g…

This study tests whether glucose-lowering medications (semaglutide and possibly dapagliflozin) can reverse prediabetes and prevent complications like eye, kidney, and nerve damage in people with heart disease. About 158 participants with prediabetes and coronary artery disease wi…

This study tests a community-based exercise program for people aged 50 and older who have at least two chronic conditions, such as heart disease, diabetes, arthritis, or obesity. The program is designed to improve muscle strength, heart and lung fitness, and overall well-being. R…

This study compares two blood thinners, bivalirudin and heparin, used during a heart procedure called PCI in people with acute coronary syndrome who are at high risk of bleeding. About 5,270 participants will be randomly assigned to receive one of the two drugs. The goal is to se…

This study tests whether using a laser to clear re-narrowed heart stents works better than standard balloon treatment. About 1,260 adults with drug-eluting stent restenosis will be enrolled. The goal is to see if laser-assisted angioplasty reduces heart-related deaths, heart atta…

This study tests whether heart attack patients with high bleeding risk can safely take blood thinners for only one month after a special drug-coated stent, instead of the usual 12 months. About 468 participants will be randomly assigned to the shorter or standard therapy. The goa…

This study tests two different ways to program an implantable defibrillator (ICD) to stop dangerous fast heartbeats. About 4,000 people with heart disease who need an ICD will be assigned to one of two pacing patterns (burst or ramp) and followed for up to 10 years. The goal is t…

This Phase 3 trial tests whether a drug called EA-230 can help people recover faster after coronary artery bypass surgery. About 300 adults scheduled for elective bypass surgery will receive either EA-230 or a placebo during the operation. Researchers will measure how long partic…

This study tests whether taking vitamin B supplements before and after heart surgery can lower the chance of serious problems like heart attack, stroke, or irregular heartbeat. About 1,000 adults having heart surgery will take either vitamin B or a placebo daily for 6 months afte…

This study tests whether a smartphone app can help people with coronary heart disease better manage their blood pressure and cholesterol after having a stent placed. About 792 participants will either use the app for one year or receive usual care. The app reminds patients to che…

This study looks at whether a medical-grade smartwatch (CardioWatch 287-2) can improve a 13-week virtual cardiac rehab program for people with heart disease. About 216 participants will either use the watch or not, and researchers will compare their progress in areas like exercis…

This study tests whether a combination of minimally invasive bypass surgery (through small chest incisions) and stents can match or beat standard open-heart bypass for people with blockages in all three main heart arteries. The trial will enroll 250 adults and measure complicatio…

This study tests if a new hybrid approach—using one stent plus a drug-coated balloon—works better than the usual two-stent method for treating a severe blockage in the left main coronary artery. About 800 adults with this condition will be randomly assigned to one of the two trea…

This study compares two methods to treat severely calcified coronary arteries: one uses a special balloon that inflates at very high pressure, and the other combines a rotating burr with sound waves to break up calcium. Researchers will enroll 162 adults with hardened arteries to…

This study tests whether an AI-powered app called 'Smart family doctor' can help people who have had heart surgery (bypass or stent) better control their blood pressure, blood sugar, and cholesterol. About 951 participants from 10-20 hospitals will use the app for personalized he…

This study tests a device called CA330 that filters blood during heart surgery to reduce severe bleeding. It includes 120 adults on blood thinners who need non-elective heart surgery. Participants are randomly assigned to receive either the filter plus standard care or standard c…

This study compares two medical devices (Amplatzer Amulet and LAmbre) used to close a small pouch in the heart called the left atrial appendage. The goal is to reduce stroke risk in people with an irregular heartbeat (atrial fibrillation) who are at high risk for bleeding from bl…

This study tests whether adding a PCSK9 inhibitor (a strong cholesterol-lowering drug) to standard statin therapy can stabilize fatty plaques in the arteries of people who recently had a heart attack. About 212 participants will receive either the drug combination or standard car…

This study tests whether a robotic system can safely assist doctors in opening blocked heart arteries. About 170 adults with coronary artery disease will be randomly assigned to receive the standard procedure or one assisted by the robot. The goal is to see if the robot can reduc…

This study looks at whether older adults (65+) who get a heart stent can safely stop one of their blood thinners (aspirin) after just 7 days instead of the usual 3 to 12 months. The goal is to see if this shorter treatment reduces bleeding risks without increasing heart attacks, …

This study tests whether a special cardiac rehabilitation program can improve muscle strength and reduce inflammation in elderly patients with both heart disease and sarcopenia (age-related muscle loss). One hundred participants will either receive rehab plus standard care or sta…

This study looks at whether taking propionic acid (a natural substance made by gut bacteria) can improve blood vessel function and reduce inflammation in 20 adults with coronary artery disease. Participants will take the supplement for 4 weeks, and researchers will measure change…

This study will test whether adding a special breathing exercise (inspiratory muscle training) to standard cardiac rehab helps heart patients recover better. About 80 adults who have been hospitalized for a heart condition will take part. The main goal is to see if the training i…

This study tests Mobili®, a portable digital dispenser that automatically gives the right pills at the right time. Researchers will enroll 96 adults with diabetes or heart disease who take at least two daily medications. Participants use the device for a period, and the study mea…

This study looks at 140 heart disease patients who also need a non-emergency surgery. Half will get a heart artery-opening procedure (PCI) before their surgery, and half will have it after. The goal is to see which timing leads to fewer heart attacks, deaths, or repeat procedures…

This study will compare two modern treatments for blocked coronary arteries: a new-generation bioabsorbable scaffold (a temporary mesh that dissolves over time) and a drug-coated balloon (a balloon that releases medication to prevent re-blockage). 150 patients with blockages in l…

This study looks at whether a 12-week cardiac rehabilitation program—including supervised exercise, education, and lifestyle advice—can improve heart function and quality of life in people who have had a heart attack treated with stenting. One hundred participants will be randoml…

This study tests a comprehensive management service package for older adults (65+) who have two or more chronic conditions like high blood pressure, diabetes, or arthritis. The package includes digital tools, personalized lifestyle advice, and long-term support. Researchers will …

This study tests a new radioactive tracer called 18F-FAPI-74 that may help detect scar tissue (fibrosis) in the heart and lungs earlier than current methods. Researchers will compare this new PET/CT scan to standard imaging in 210 adults with conditions like lung disease or heart…

This study tests whether an artificial intelligence system called AngioAI+ can accurately diagnose two types of coronary artery disease using standard angiogram images. The research involves 620 adults with suspected coronary artery disease who are already scheduled for an angiog…

This study tests a small, handheld ECG device that records heart activity when held against the chest and sends the data via smartphone to a doctor. Researchers will enroll 594 adults with known or suspected heart conditions to see if the new device is as good as the standard 10-…

This study will test whether a deep learning-based image reconstruction method can improve the quality of coronary CT scans. Researchers will look at existing scans from 200 patients who had a CT angiogram for suspected heart disease. Two radiologists will rate the images on a sc…

This study tests a new cardiac MRI method called Free-Running Framework (FRF) that lets patients breathe normally and skips the sticky ECG electrodes. It captures a 3D image of the whole heart in one go, potentially making scans faster and more comfortable. Researchers will compa…

This pilot study will test whether breathing controlled amounts of carbon dioxide (CO2) can help doctors see blood flow in the heart using MRI, without needing standard contrast dyes. Thirty adults with known or suspected coronary artery disease will take part. The goal is to che…

This pilot study tests whether a computer-controlled device that delivers precise gas mixtures can safely help identify coronary artery disease in people without known heart problems. Eighty healthy adults aged 45 and older will breathe different gas concentrations while their vi…

This study looks at whether a special heart scan (CZT-SPECT) can better predict heart attacks, strokes, and heart failure in people with chronic kidney disease. Current tests often miss heart problems in these patients. The study will follow 283 participants for two years to see …

This study tests whether a simple, 1-minute electrocardiogram (ECG) analyzed by artificial intelligence can accurately detect significant blockages in the heart's arteries. Researchers will compare the AI's predictions against standard imaging tests in 400 adults. If successful, …

This study tests advanced CT scans to find dangerous blockages in heart arteries without needing to insert a tube into the heart. About 142 adults with moderate blockages will get two types of CT scans, and results will be compared to the standard invasive test. The goal is to se…

This study tests a new, contactless camera technology that measures heart rate, blood pressure, and heart disease risk from a short video of your face. Researchers will compare these readings to standard medical tests in 300 adults aged 30 and older in Jakarta. If accurate, this …

This study will enroll 5000 adults to see if a one-minute, single-lead ECG, analyzed by machine learning, can detect heart conditions like high blood pressure, heart failure, and diabetes. Participants will have their ECG recorded twice and compared with full medical exams. The g…

This study will check if a fast, bedside heart ultrasound performed by emergency doctors or interpreted by artificial intelligence can accurately detect heart problems in children who already have heart disease. About 200 children aged 0-21 will be included. The results will be c…

This study will test a computer algorithm called ECGio that analyzes electrocardiograms (ECGs) to see if it can accurately detect significant coronary artery disease (blockages in heart arteries). Researchers will compare ECGio's results to standard imaging tests like angiograms …

This study is testing a new digital stethoscope that listens for subtle changes in heart sounds to detect coronary artery disease and valve problems earlier. Researchers will record heart sounds from 500 adults who are already scheduled for heart scans or echocardiograms. The goa…

This study looks at whether using a special heart scan (coronary CTA plus CT-FFR) helps doctors make better decisions for people with chest pain who are at moderate risk. About 2,000 emergency room patients will be randomly assigned to get this scan or standard care. The goal is …

This study looks at whether a non-invasive ultrasound of the heart can diagnose blood vessel problems in people with chest pain but no blocked arteries. About 35 patients who previously had an invasive heart test will get an ultrasound instead. The goal is to see if the ultrasoun…

This trial tests a tool called SCOUT that helps doctors check AI-generated diagnoses for coronary heart disease. Seven cardiologists will review cases either with SCOUT's assistance or through standard manual review. The goal is to see if SCOUT can reduce the time doctors spend p…

This study will test a new type of CT scanner that uses silicon-based detectors to take detailed pictures of the heart. The goal is to see if it can provide clearer images of coronary arteries while using less radiation and contrast dye than current scanners. About 1,000 adults r…

This study looks at a new method to diagnose problems in the small blood vessels of the heart in people who have chest pain but no blockages in their main arteries. Researchers will test if the procedure is safe, reliable, and can be done consistently. About 100 adults will take …

This study is testing a new tool called UFR, which uses ultrasound images to measure blockages in heart arteries during a heart attack. Currently, the most accurate method requires patients to return 30 days later for a second invasive procedure. The study will enroll 200 heart a…

This study tests whether an artificial intelligence (AI) tool can help emergency room doctors interpret heart CT scans more accurately. About 530 adults with chest pain and intermediate risk of a heart attack will be randomly assigned to have their scans read with or without AI a…

This study looks at whether two blood markers – mean platelet volume (MPV) and the systemic inflammatory response index (SIRI) – can help diagnose and predict outcomes in people with acute coronary syndrome (heart attack or unstable angina). Researchers will measure these markers…

This study tests whether placing soft foam dressings on the skin before heart surgery can prevent pressure injuries (bedsores). About 80 adults having long heart surgeries will be enrolled. Researchers will check for new skin injuries after surgery and track how severe they are. …

This study looks at whether giving patients and their doctors a polygenic risk score — a genetic test that estimates future risk of coronary heart disease — helps more people start taking statins to prevent heart problems. Researchers will enroll 200 adults aged 40-69 without pri…

This study tests whether taking a low dose of colchicine (0.5 mg) every day for two years after coronary artery bypass grafting (CABG) can prevent the new blood vessel grafts from failing. About 622 adults who just had bypass surgery will be randomly assigned to get either colchi…

This study tests whether a numbing injection around a nerve cluster in the neck, given just before heart bypass surgery, can prevent a common complication called atrial fibrillation (irregular heartbeat) in the first week after surgery. About 450 adults scheduled for bypass will …

This study will test two different surgical techniques used during heart bypass surgery to see which one better prevents a common complication called atrial fibrillation (irregular heartbeat). The trial will involve 122 adults having their first planned bypass surgery. Researcher…

This pilot study explores whether non-drug strategies like virtual reality or relaxing soundscapes can reduce anxiety and pain in adults undergoing scheduled coronary angiography or angioplasty. Participants will be assigned to listen to calming sounds, experience a virtual reali…

This study looks at whether 12 virtual health coaching sessions over 16 weeks can help people with heart disease (like heart failure or a heart attack) improve their health, reduce stress, and lower the chance of going back to the hospital. About 70 adults will take part, and the…

This study tests whether injecting a local anesthetic near the stellate ganglion in the neck, guided by ultrasound, can improve how patients feel after heart surgery. The block temporarily calms part of the nervous system, which may reduce pain, improve sleep, and lower the risk …

This study tests whether wearing eye masks and/or earplugs at night can improve sleep quality and reduce delirium in 128 patients recovering from coronary artery bypass surgery. Participants will be randomly assigned to use these aids on the first three nights after surgery. Rese…

This study tests whether injecting a long-acting numbing medicine (bupivacaine) through chest tubes can safely reduce pain and lower the need for strong painkillers after heart bypass surgery. Sixty adults will receive either the numbing medicine or a saltwater placebo whenever t…

This study tests whether using mild electrical pulses on the diaphragm and belly muscles can improve breathing, heart function, and exercise ability in people who recently had a heart artery-opening procedure (angioplasty). 42 adults will receive either standard rehab plus this s…

This study compares three pain management approaches for 120 adults undergoing coronary artery bypass surgery: standard painkillers alone, standard plus a parasternal nerve block, or standard plus both parasternal and adductor canal blocks. The goal is to see if adding these nerv…

This study tests whether low-intensity focused ultrasound (LIFU) applied to a nerve cluster in the neck can improve sleep quality and heart rate control in people recovering from heart surgery. 200 participants will receive either real or sham ultrasound daily for 3-7 days after …

This study compares two types of exercise—elliptical training and Swiss ball aerobics—to see which better helps people recover after heart bypass surgery (CABG). Researchers will measure improvements in walking ability, heart rate, shortness of breath, and quality of life. The st…

This study tests whether adding a special breathing exercise device (IMT Threshold) to standard rehab can help people recover faster after coronary artery bypass graft surgery. The goal is to reduce time in the hospital and prevent serious breathing complications like pneumonia. …

This study tests whether a structured nursing program—including education, emotional support, and follow-up calls—can help heart bypass patients and their caregivers adapt better during recovery at home. About 40 adults who recently had heart surgery and their primary caregivers …

This study tests if a new flexible cable (SuperCable) is better than standard steel wire for closing the breastbone after heart surgery. About 86 adults will be randomly assigned to one method. The goal is to see if SuperCable leads to faster bone healing, less pain, and shorter …

This study tests whether foot massage or kinesio taping can help older adults (65+) move better and feel less afraid of movement after heart surgery. Sixty participants will receive one of the two treatments daily for a week. Researchers will measure mobility, pain, and fear of m…

This study looks at whether a back massage with mentholated ointment (like Vicks) can lower pain and anxiety in people who just had coronary bypass surgery. 120 adults will be split into three groups: one gets a back massage with mentholated ointment, one gets a back massage with…

This study looks at whether a supplement called Neurofast® can help people who have both anxiety and heart problems. 80 adults aged 18-70 will take the supplement or no extra treatment for 12 weeks. Researchers will measure changes in anxiety, heart rate, and blood pressure.

This study tests whether a personalized AI-generated video, delivered by a nurse avatar, can improve recovery for people after coronary artery bypass surgery. About 128 patients will either get standard discharge instructions or the AI video plus standard care. Researchers will m…

This study will compare two types of aerobic exercise—interval training and continuous training—in 48 people with stable coronary artery disease. Participants will exercise twice a week for 8 weeks as part of a cardiac rehab program. Researchers will measure heart efficiency, exe…

This study tests a small mesh device called a coronary sinus reducer in 25 people with severe chest pain from advanced coronary artery disease who cannot have stents or bypass surgery. The device is placed in a heart vein to increase pressure and improve blood flow. Researchers w…

This study tests whether starting gentle movement earlier than usual can reduce back pain in people who have had a procedure to open blocked heart arteries. After this procedure, patients often lie flat for hours, which can cause back pain. The study will compare early mobilisati…

This study tests whether Emotional Freedom Techniques (EFT) — a therapy that combines tapping on specific body points with focused thoughts — can help people recovering from coronary artery bypass surgery. Researchers will compare 33 patients who receive EFT plus standard care ag…

This study tests whether spraying room-temperature water into the mouth after a breathing tube is removed can reduce thirst, pain, and anxiety in people who had coronary artery bypass surgery. Forty-two adults will receive the spray twice an hour for four hours. The goal is to se…

This study tests a new care program for older adults in Thailand who have had a heart attack. The program combines in-person education, motivational counseling, and a mobile app to help them adopt healthy habits and track their recovery. Researchers will measure if this approach …

This study looks at whether listening to guided meditation audio can reduce stress and anxiety in people having open-heart surgery. About 72 adults will either receive meditation sessions or standard care. Researchers will measure stress hormones, blood sugar, and anxiety levels …

This study tests an 8-week mindfulness program designed to reduce anxiety and improve quality of life in women with coronary artery disease. Researchers will enroll 70 women who have had CAD for at least a month and have elevated anxiety. The program includes meditation, breathin…

This study looks at whether doing special breathing exercises before heart bypass surgery can help improve oxygen levels afterward. It will include 45 men aged 50 to 60. Some will use an incentive spirometer, some will use an inspiratory muscle trainer, and others will receive st…

This study tests whether avoiding opioids during heart bypass surgery helps elderly patients recover faster. Sixty patients aged 65 and older will receive either opioid-free anesthesia with dexmedetomidine and ketamine or standard opioid-based anesthesia. The goal is to see if th…

This study tests whether a short virtual reality (VR) session before a first-time cardiac catheterization can lower patient anxiety and improve satisfaction. About 120 adults in Oman will be randomly assigned to either the VR experience or standard education. Researchers will mea…

This study tests whether adding a short, guided mindfulness meditation session to standard cardiac rehabilitation can help heart patients feel better and control their blood pressure. Eighty adults with heart disease will be split into two groups: one gets standard rehab plus med…

This study will compare cannabis, opioids, and two non-drug therapies (MIRE and TENS) in 1,000 people with chronic pain or circulatory disorders. The goal is to find safer, less addictive pain relief options. Researchers will measure changes in pain and nerve function using objec…

This study tests whether applying an ice bag to the groin area after a heart procedure (called PCI) can reduce pain and bruising. Sixty adults who had the procedure through the femoral artery will receive ice therapy for 20 minutes at a time. Researchers will measure pain levels …

This study tests whether a home-based cardiac rehabilitation program can improve quality of life and health behaviors in heart patients living in low-resource settings in Pakistan. The program includes diet advice, exercise suggestions, medication reminders, and counseling, deliv…

This study will take standard heart CT scans from 1000 adults with structural heart disease and use a super-computer to create ultra-high-resolution images. The goal is to see if these enhanced images show more detail than the originals. No new treatments are being tested; it's a…

This study uses advanced 4D MRI scans to measure blood flow and heart function in adults with heart disease or cancer. Researchers aim to see if these detailed images can help predict how these diseases will progress. The study involves 1,000 participants who are already schedule…

This study will interview 15 people from ethnic minority backgrounds in the UK who have heart disease. The goal is to understand their views on the diet and lifestyle advice they get from doctors, and whether it fits their cultural and religious customs. Researchers hope to learn…

This study checks whether an Apple Watch Series 9 can accurately measure key health indicators—like oxygen levels and exercise capacity—in adults with heart conditions such as congenital heart disease, heart failure, or coronary artery disease. Participants wear the smartwatch du…

This observational study will follow 2,352 adults with coronary heart disease to see how factors like blood sugar, sleep, and heart imaging relate to thinking and memory problems. Participants will take memory tests and undergo scans and blood work during a hospital stay. The goa…

This study tests whether it is possible to run a larger trial comparing two ways of using a breathing machine (ventilator) in critically ill heart patients who need help breathing. The two modes are volume-controlled (delivers a set amount of air each breath) and pressure-control…

This study looks at 150 adults having coronary bypass surgery to find out how often hidden heart injury occurs. Researchers use a sensitive blood test (troponin) and heart MRI to detect damage that standard tests might miss. The goal is to improve diagnosis and long-term care aft…

This observational study at a French hospital will ask 20 heart rehab patients and their care teams about what stops them from getting or offering psychological and social support. The goal is to understand these barriers so that hospitals can better help patients return to work …

This study will follow 600 adults having off-pump heart bypass surgery to see how often memory and thinking problems occur afterward. Participants take a simple thinking test before and after surgery. The goal is to understand what factors might increase the risk of these problem…

This study is creating a decision aid for people with a rare heart condition called right anomalous aortic origin of a coronary artery (R-AAOCA). The condition raises the risk of sudden cardiac death, but the best management—surgery or careful observation—isn't clear. The aid wil…

This study will observe 110 adults having planned heart bypass surgery. Researchers will record settings on the breathing machine during surgery and check if patients develop lung complications like pneumonia or need a breathing tube for too long. No new treatments are given—the …

This study aims to see if a quicker MRI scan can produce images of blood vessel walls that are just as good as the standard, longer scan. Researchers will enroll 15 adults who already need a vessel wall MRI as part of their care. The faster scan will be compared to the regular on…

This study looks back at medical records of 850 patients aged 80 and older who had a heart stent procedure at a UK hospital over seven years. Researchers will describe the patients' health, age, and frailty, and track complications like heart attack, stroke, or death up to one ye…

This study will examine how the heart-lung machine used during cardiac surgery changes platelet function and metabolism. Researchers will take blood samples from 100 adult heart surgery patients at several time points. The goal is to link these platelet changes to post-surgery in…

This study will create a computer tool to predict which older adults are at high risk for serious problems after heart or blood vessel surgery. It will also test if special programs before and during surgery can help prevent confusion, heart issues, and death. About 1,200 people …

This study will follow 600 adults who have had a stent placed or bypass surgery for coronary artery disease. Researchers will collect medical information, blood samples, and traditional Chinese medicine symptoms over 12 months. Using artificial intelligence, they aim to create a …

This study tests two different computer alerts designed to encourage doctors to refer heart patients to cardiac rehab. About 7,000 adults who had heart surgery or a stent in the past year will take part. The goal is to see if these simple reminders increase the number of people w…

This study compares how much radiation doctors are exposed to during heart procedures (PCI) when using the left distal wrist versus the right wrist for artery access. About 748 patients scheduled for PCI will take part. The goal is to see if the left wrist approach reduces radiat…

This study looks at whether a new province-wide electronic health record system (called Connect Care) improves outcomes for adults with chronic diseases like diabetes, heart failure, or kidney disease. Researchers will compare hospital readmission and death rates before and after…

This study looks at 1,000 adults who had planned heart bypass surgery. Researchers will review existing hospital records to see if changes in routine blood tests (like inflammation and kidney markers) in the first hours after surgery can identify patients at higher risk for compl…

This pilot study tests whether a larger trial comparing two methods of harvesting the left internal mammary artery (LIMA) for heart bypass surgery is feasible. About 35 adults having planned bypass surgery will be randomly assigned to either the skeletonized method (isolating the…

This study tests whether using a CT scan to plan a heart stent procedure (PCI) makes it faster, safer, and more effective than the usual approach. About 200 adults with coronary artery disease will either get CT-guided planning or standard care. Researchers will compare procedure…

This study will examine 250 adults with chest pain but no major blockages in their heart arteries (a condition called INOCA). Researchers will collect cells from the heart's blood vessels during a standard angiogram and track symptoms, activity, and function over one year using q…

This study will follow 1000 adults in China with severe coronary artery disease who are too high-risk for bypass surgery and need complex angioplasty. Researchers will collect data on their health, procedures, and outcomes for one year to see what factors affect survival and comp…

This observational study will track 87 people who are already scheduled to receive treatment with the Recana Thrombectomy Catheter System for blocked veins in their legs. The goal is to see how safe the device is and how well it works at clearing the blockages during the procedur…

This observational study in Mexico will follow 30 adults already taking tirzepatide for conditions like diabetes or obesity. Researchers will use MRI scans of the knees, CT scans of the heart, and body composition tests to see how the drug affects cartilage, heart fat, and overal…

This observational study will follow 3000 patients with severely calcified coronary arteries who undergo a procedure to open the blockages (PCI). Researchers will track outcomes like heart attacks and repeat procedures over time. The goal is to learn which techniques work best in…

This study will use AI-guided CT scans to look for signs of heart disease in 100 former high-intensity athletes, like NFL alumni or Division I players, aged 30 and older. The goal is to find out how common coronary artery disease is in this group and understand the types of plaqu…

This study looks at whether adding a special heart function test (coronary function testing) to the standard artery-opening procedure (angioplasty) can better relieve chest pain and improve quality of life. About 450 adults with a significant blockage in a major heart artery will…

This pilot study will test whether a women-focused education program, called Cardiac College for Women, helps women with heart disease learn more about their condition and feel better. About 50 women in cardiac rehab across Canada will either get the program plus usual care or us…

This study will look at how consistently nearly 6,000 adults in Italy take three newer cholesterol-lowering drugs (inclisiran, evolocumab, and alirocumab) over the long term. Researchers will analyze prescription records to measure adherence and persistence in everyday medical pr…

This study will test a new type of CT scan (photon counting CT) to see if it can give doctors a clearer picture of the fatty deposits (plaques) inside heart arteries. The goal is to find out if these detailed images can help predict who might have a heart attack or other serious …

This study looks at whether a cardiopulmonary exercise test (CPET) can help predict serious heart problems in people with coronary heart disease. Researchers will review medical records from 15,000 patients and track their health over time. The goal is to see if CPET results are …

The MISTIC study will examine 1000 adults to see if early, symptom-free artery disease is linked to thinking and memory problems. Participants will get non-invasive imaging of their arteries and cognitive tests. This is an observational study, not a treatment trial, aiming to imp…

This study will examine 108 adults aged 30-65 to see if a gene called Klotho, certain mouth bacteria, and viruses are linked to gum disease and acute coronary syndrome (a type of heart attack). Researchers will measure gum health and collect samples to look for these markers. The…

This study will follow 1,800 people who had a stent placed in their heart arteries using a special camera (OCT). Researchers want to see if new measurements from routine angiograms can better predict future heart problems like heart attacks or chest pain. The goal is to improve h…

This study looks at how ups and downs in blood sugar affect diabetic patients admitted to the coronary care unit. Researchers will track 120 adults with diabetes and heart disease to see if glucose variability increases the risk of death or major heart problems like heart attack …

This study looks at 212 heart disease patients who take antiplatelet drugs and have sudden upper stomach bleeding. It compares having an endoscopy within 12 hours versus waiting 12-24 hours to see which timing is safer and more effective. The goal is to find the best approach to …

This study tests whether giving people with heart or lung conditions real-time air pollution data helps them exercise outdoors more safely. 80 participants will use a smartphone platform that tracks their walking and local air quality. The goal is to see if this approach reduces …

This study will follow 6000 people with heart disease or recent heart attacks for years. Researchers will collect blood, urine, and stool samples, plus medical data, to build a huge database. They hope artificial intelligence can find new ways to predict, diagnose, and treat hear…

This study will follow 600 people who need either bypass surgery (CABG) or a stent (PCI) to open blocked heart arteries. Researchers will test memory and thinking skills before the procedure and again at 1 month, 1 year, and 2 years after. The goal is to see if one approach leads…

This study will test new MRI methods to find early signs of heart disease in 1000 adults. Researchers want to see if these scans can detect tiny changes in heart muscle before standard tests do. Participants will have MRI scans and blood work, but no treatment is given. The goal …

This study looks at how a low dose of colchicine, an anti-inflammatory drug, changes proteins in the blood of people with coronary heart disease and high inflammation. Researchers will compare protein levels before and after one month of treatment in 176 patients. The goal is to …

This study will follow 300 people having planned coronary bypass surgery to see if the amount of belly fat they carry affects their risk of developing atrial fibrillation (a type of irregular heartbeat) after the operation. Before surgery, doctors will use ultrasound to measure t…

This study tests whether sending an electronic letter to people with heart disease and high cholesterol encourages them to get their cholesterol checked. Researchers will compare those who receive the letter to those who don't, using national health records to track results. The …

This study will test a simple score to predict which patients may become confused (delirium) after planned heart surgery. About 100 adults will be checked before surgery using memory, orientation, and frailty tests. The goal is to identify high-risk patients early so doctors can …

This study develops and tests an AI system that reads de-identified patient admission notes to classify four types of coronary syndromes, including heart attacks and angina. The tool is designed to protect patient privacy while helping doctors diagnose more accurately and quickly…

This study looks at whether a special MRI scan can predict if patients will develop an irregular heartbeat (atrial fibrillation) after heart bypass surgery. About 100 adults scheduled for bypass will get an MRI before surgery and wear a heart monitor for a year. The goal is to fi…

This study will examine the medical records of 200 adults with heart disease who had a special X-ray of their heart arteries. Researchers want to see if a score called the triglyceride-glucose (TyG) index, which comes from a routine blood test, is higher in people who have a comp…

This study will test a new computer program designed to help doctors make better decisions for patients with high cholesterol and heart disease. Researchers will review the medical records of 500 adults and compare the program's recommendations to what doctors actually prescribed…

This study is creating an AI tool to help doctors decide the best heart treatment for people who have both immune thrombocytopenia (ITP) and coronary artery disease. Researchers will look at past patient data to build the tool, then test it on 600 new patients. The goal is to bet…

This study looks at a protein called GARP and related inflammatory markers in the blood of 600 adults with either acute (sudden) or chronic (long-term) coronary syndrome. Participants will have blood drawn during a routine heart catheterization. The goal is to understand how GARP…

This pilot study tests whether fecal microbiota transplantation (FMT) can change the gut microbiome in 30 people with type 2 diabetes and stable coronary artery disease. Participants receive processed stool from healthy donors via colonoscopy. The goal is to see if this alters gu…

This study will compare two types of heart-lung machines used during coronary bypass surgery to see how they affect blood flow to the brain. Researchers will measure brain pressure using an eye ultrasound and brain oxygen levels with a forehead sensor in 70 patients. The goal is …

This study compares two imaging methods—CT-FFR and QFR—to see which better guides treatment decisions for people with coronary artery disease. About 1,400 participants with moderate blockages will be randomly assigned to one of the two approaches. The goal is to find out which me…

This study looks at whether doctors would use an AI program called ECGio to help decide care for patients who might have heart artery disease. About 10,000 adults with risk factors like high blood pressure or diabetes will be included. The main goal is to see how often doctors ch…

This large registry study will follow over 2,700 postmenopausal women aged 45-75 who use newer forms of hormone replacement therapy (creams, gels, sprays). The goal is to see if these modern delivery methods lower the risk of heart attacks, strokes, and other cardiovascular event…

This study will follow 4,000 intensive care patients aged 80 and older to see how chronic and acute heart conditions impact their survival, daily function, and quality of life. Researchers will use simple tests to measure frailty and independence. The goal is to help doctors bett…

This study will use a special camera (OCT) to look inside heart arteries before a standard balloon procedure. Researchers want to see if the type of plaque (fatty, hard, or scar-like) affects how well patients do afterward. About 600 people with coronary artery disease will take …

This study looks at ways to help surgeons use more artery grafts instead of vein grafts during heart bypass surgery, since artery grafts last longer. It will involve about 8,700 patients across many hospitals. The study does not test a new drug or device, but rather tests trainin…

This study will follow 500 Beijing residents aged 60 and older to see how urinary function (like bladder and kidney health) relates to the development of multiple chronic conditions such as diabetes, heart disease, and Alzheimer's. Participants will have regular health checks, bl…

This study looks at how well hospitals follow guidelines for blood thinner use after heart stent placement. It will enroll 3,500 patients with acute coronary syndrome who are at high risk for bleeding. Researchers will track their treatment and outcomes for 12 months to see if a …

This study will collect information from 1,200 patients in the French West Indies and Guiana who received ECMO, a machine that helps the heart and lungs. Researchers aim to track survival rates and complications to better understand how ECMO works in this region. The study does n…

This study will use data from over 10,000 people to create a risk prediction model for coronary artery disease. Researchers will combine heart imaging scans (like CT angiograms) with blood markers (like cholesterol) to better identify who is at high risk for heart attacks or othe…

This study will compare three different fluids used to protect the heart during coronary artery bypass surgery. Researchers will measure tiny particles and immune system markers in the blood to see which fluid causes the least heart muscle injury. The goal is to find the safest a…

This study will observe 500 adults with stable or acute heart artery disease who receive a laser treatment called Excimer Laser Coronary Atherectomy (ELCA) during a standard procedure to open blocked arteries. The goal is to track how well the laser works and how safe it is by re…

This study will follow 150 men aged 50-80 who recently had heart bypass surgery and are going through standard cardiac rehab. Researchers will measure physical fitness, mental health, sleep problems, and biological markers at three points over several months. The goal is to find …

This study compares two ways of making treatment decisions for people with diabetes and severe blockages in all three main heart arteries. One group gets a real-time online discussion among heart specialists during an angiogram, while the other gets usual care. The goal is to see…

This study will create a national registry to collect data on 3,000 adults undergoing coronary artery bypass graft (CABG) surgery in Saudi Arabia. The goal is to track complications, recovery, and quality of life for one year after surgery. This information will help hospitals im…

This study tests whether mild hypothermia (cooling the body to about 33°C) during coronary artery bypass grafting protects the brain better than normal temperature (about 36.5°C). Researchers will use advanced brain scans and blood tests to measure brain injury in 160 adults unde…

This study will observe 400 adults who have a stroke within 28 days of a heart procedure, such as a stent or valve replacement. The goal is to learn more about these strokes, including how severe they are and how well current treatments work. No new drugs or devices are being tes…

This study looks at how low oxygen levels during sleep (from obstructive sleep apnea) are connected to problems in the tiny blood vessels of the heart. Researchers will follow 560 adults with suspected heart issues to see if sleep apnea patterns can predict future heart events li…

This study aims to create a risk model that helps doctors decide which elderly patients (over 70) with heart disease need procedures like stents or bypass surgery. Researchers will collect CT scans, blood tests, and frailty assessments from 800 participants and follow them for tw…

This study will look at 2000 adults who had a heart CT scan to find unexpected health issues outside the heart, such as lung problems or blood vessel abnormalities. The goal is to understand how often these surprise findings occur. No treatment is given; it is purely an observati…

This study will check if new risk models can better predict blood clots and bleeding in 5000 adults with coronary heart disease. Participants will be followed for one year to see how well the models work. The goal is to help doctors choose safer, more personalized treatments.

This study will ask 380 heart patients and healthcare workers at Assiut University Heart Hospital to fill out questionnaires about depression, anxiety, stress, and burnout. No treatments or changes are given—the goal is simply to find out how common these mental health problems a…

This study is looking at a specific type of hard plaque in heart arteries called a calcified nodule, which can cause sudden heart attacks and is hard to treat. Researchers will use special cameras inside the arteries to see these plaques in detail and track how patients do over t…

This study aims to understand why some people's coronary artery disease gets worse quickly while others' stays stable. Researchers will compare medical history, lab results, and imaging from 52 patients—34 with rapidly progressive disease and 18 with non-rapidly progressive disea…

This study will use transcranial Doppler (TCD) ultrasound to measure blood flow in the brains of 100 people who had a stroke and underwent endovascular therapy (clot removal). The goal is to see if TCD readings can predict complications like bleeding or brain swelling in the days…

This study will follow 6,000 people in China who have both coronary heart disease and a leaky heart valve (ischemic mitral regurgitation). Researchers will collect medical data and track outcomes like hospitalizations and deaths over two years. The goal is to understand the disea…

This study tests whether using very low radiation doses combined with special software can produce clear images of the heart's arteries. About 50 adults scheduled for a standard heart angiogram will have extra images taken with the new low-radiation method. The goal is to see if …

This study will see if an artificial intelligence program called CaRi-Heart can help doctors make better decisions about treating heart disease. About 15,000 adults getting a standard heart CT scan will have their images re-analyzed by the AI at no extra cost. The goal is to find…

This study tests a computer tool that helps doctors and cancer survivors decide together on the best heart-protective medications and tests. Researchers will enroll 60 cancer survivors at risk for heart problems. The goal is to see if the tool is easy to use and helps people foll…

This study will follow 20,000 patients with complex coronary artery disease to see how non-fatal complications during a heart procedure (stent placement) affect their risk of death over the long term. Researchers aim to identify which complications are most dangerous. The study d…

This study looks at whether measuring a type of fat in the blood, called lipoprotein(a), can help predict future heart problems in people who have had a stent placed to open a blocked artery. Researchers will follow 156 adults for one year after their procedure to see if those wi…

This study looks at 1,700 people with heart disease to see how different treatments—surgery, stents, or medication—affect kidney function over 5 years. Researchers will track changes in kidney health and check for new or worsening kidney disease. The goal is to help doctors choos…

This study will test whether an artificial intelligence (AI) system can detect pulmonary hypertension and other heart diseases using a smart stethoscope. Researchers will collect heart sound and ECG recordings from 1,000 adults already scheduled for routine echocardiography. The …

This study looks at how sleep disorders and problems with the body's automatic functions (like heart rate control) are linked in elderly people with heart disease. Researchers will study 210 patients aged 65 and older to find out how common sleep issues are and how they affect he…

This observational study will check if levels of a fatty substance called lipoprotein(a) in the blood are linked to calcium buildup in heart arteries. About 150 adults at intermediate heart risk will get a CT scan and a blood test. The goal is to see if Lp(a) can help detect earl…

This study looks at whether the bacteria in your gut can affect how your heart heals after a heart attack procedure called PCI. Researchers will measure a substance called TMAO, made by gut bacteria, in 144 patients. The goal is to see if TMAO levels are linked to changes in hear…

This study tests whether nutrition education provided by nurses can improve the eating habits and overall health of people who have recently had coronary artery bypass surgery. Researchers will enroll 160 patients and track their diet quality, weight, and well-being over time. Th…

This study will compare how well heart and lung function recover after robot-assisted heart surgery versus traditional open-heart surgery. Researchers will measure exercise capacity and breathing in 80 patients before and after surgery. The goal is to see if the less invasive rob…

This study looks at whether a 6-minute pegboard and ring test—a simple, low-cost task of moving rings between pegs—can reliably measure upper body exercise capacity in people with coronary artery disease. Researchers will compare the results to standard cardiopulmonary exercise t…

This study looks at whether eating before an elective cardiac catheterization is safe and better for patients. Researchers will randomly assign 2000 adults to either fast or eat as desired before their procedure. They will compare patient satisfaction and breathing complications …

This registry will enroll 1010 minority patients with complex coronary artery disease to see if using intravascular ultrasound (IVUS) during stent placement improves outcomes. The study tracks heart-related death, heart attacks, and need for repeat procedures over time. It aims t…