Could a simple nitrate boost help solve the mystery of chest pain?
NCT ID NCT06896903
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at whether giving a nitrate drug during a heart test can better detect blood flow problems in people who have chest pain but no blocked arteries. About 50 adults will get the standard test, then a repeat test after nitrates. The goal is to see if nitrates improve the accuracy of diagnosing microvascular angina.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
intracoronary nitroglycerine (nitrate)
What this could lead to
If successful, this could make coronary reactivity testing more accurate for diagnosing microvascular angina, helping doctors better identify the cause of chest pain.
What could go wrong
This is a small, early-phase diagnostic study with only 50 participants. The improvement from nitrates may be small or not clinically meaningful, and results may not apply to all patients.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Baylor Scott & White The Heart Hospital - Plano
RECRUITINGPlano, Texas, 75093, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••