Could a simple nitrate boost help solve the mystery of chest pain?

NCT ID NCT06896903

Recruiting now Diagnosis Sponsor: Baylor Research Institute Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether giving a nitrate drug during a heart test can better detect blood flow problems in people who have chest pain but no blocked arteries. About 50 adults will get the standard test, then a repeat test after nitrates. The goal is to see if nitrates improve the accuracy of diagnosing microvascular angina.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: intracoronary nitroglycerine (nitrate)
What this could lead to: If successful, this could make coronary reactivity testing more accurate for diagnosing microvascular angina, helping doctors better identify the cause of chest pain.
What could go wrong: This is a small, early-phase diagnostic study with only 50 participants. The improvement from nitrates may be small or not clinically meaningful, and results may not apply to all patients.

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Conditions

The condition(s) this trial relates to.

coronary microvascular disorder nonobstructive coronary artery disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANOCA - ANGINA WITH NON-OBSTRUCTIVE CORONARY ARTERIES INOCA (ISCHEMIA WITH NON OBSTRUCTIVE CORONARY ARTERY DISEASE)

Contacts and locations

Locations

Baylor Scott & White The Heart Hospital - Plano
RECRUITING

Plano, Texas, 75093, United States

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