Balloon vs. stent: new trial could change how we treat blocked arteries

NCT ID NCT07363161

Recruiting now Disease control Sponsor: B. Braun Melsungen AG Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 21, 2026 · Updated 4 times

Summary

This study is testing whether a drug-coated balloon is as good as a drug-eluting stent for treating complex coronary artery disease in high-risk patients. About 2,184 participants will be randomly assigned to receive one of the two treatments. The main goal is to see if the balloon works just as well at preventing heart-related events like death, heart attack, or the need for another procedure over 3 years.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: drug-coated balloon (SeQuent® SCB) and drug-eluting stent
What this could lead to: If successful, this could show that a drug-coated balloon is as effective as a stent for treating complex heart disease, with potentially fewer bleeding risks.
What could go wrong: This is a non-inferiority trial, meaning it aims to prove the balloon is not worse than the stent, not necessarily better. Results may not apply to all patients, and long-term outcomes are still being studied.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

coronary artery disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CORONARY ARTERY DISEASE (CAD)

Contacts and locations

Locations

Stadtspital Zürich - Klinik für Kardiologie
RECRUITING

Zurich, 8063, Switzerland
University Hospital Basel
NOT_YET_RECRUITING

Basel, 4031, Switzerland
Universität des Saarlandes - Klinik für Innere Medizin III
NOT_YET_RECRUITING

Homburg, 66421, Germany

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