M.d. Anderson Cancer Center

This early-phase study is testing a personalized peptide vaccine for people with advanced pancreatic or colorectal cancer that has spread. The vaccine is made from each patient's own tumor cells and blood, aiming to help the immune system attack the cancer. The main goals are to …

This study tests a two-step treatment for hairy cell leukemia, a rare blood cancer. First, patients receive chemotherapy (cladribine) to kill cancer cells, then an immunotherapy drug (rituximab) to help the immune system attack any remaining cells. The goal is to see if adding ri…

This study looks at whether targeted radiation can help control multiple myeloma that is still active after CAR-T cell therapy. About 30 adults whose cancer did not fully respond to CAR-T will receive radiation to up to five tumor sites. The goal is to see if this approach improv…

This study is for people with advanced intrahepatic cholangiocarcinoma, a type of bile duct cancer that has spread. It compares standard drug therapy alone versus drug therapy plus targeted radiation to the liver. The goal is to see if adding radiation improves outcomes and is sa…

This study tests whether combining three drugs—pemigatinib, atezolizumab, and bevacizumab—can help control advanced bile duct cancer that has a specific genetic change (FGFR2 fusion). About 25 adults whose cancer has not responded to other treatments will take part. The main goal…

This study tests whether combining two drugs, mosunetuzumab and zanubrutinib, can safely control marginal zone lymphoma that has returned or stopped responding to prior treatment. About 36 adults with stage II–IV disease will receive the combination. The goal is to see how well t…

This early-phase study tests a combination of two drugs (BMS-986504 and olaparib) in adults with advanced solid tumors that have lost a gene called MTAP. The main goal is to find safe doses and understand side effects. About 36 people will take part, and the study is currently re…

This early-stage trial is for people with weakened immune systems who have an adenovirus infection. Researchers are testing a treatment made from donor immune cells grown in a lab to see if it is safe and can help fight the virus. The study involves 16 participants and focuses on…

This study tests whether the drug olverembatinib can control newly diagnosed chronic myeloid leukemia (CML) in its early phase. About 50 adults will take the drug alone and be monitored for side effects and how well the cancer responds. The goal is to find a treatment that keeps …

This study tests a new drug, SAR445877, in people with advanced non-small cell lung cancer that has stopped responding to immunotherapy. The goal is to see if the drug can help control the cancer. About 29 adults will take part, and researchers will monitor safety and side effect…

This study tests whether having a partner to exercise with helps inactive women become more physically active. Researchers will enroll 500 women aged 18-65 who are not currently active enough. Participants will either receive a standard individual program or a partner-based progr…

This study tests whether giving specially engineered natural killer (NK) cells from donated cord blood, along with chemotherapy, is safe and effective for people with relapsed or hard-to-treat blood cancers like leukemia, lymphoma, and multiple myeloma. About 80 participants will…

This study tests whether adding the immunotherapy drug pembrolizumab to standard chemotherapy before surgery can help people with early-stage triple negative breast cancer. About 28 participants will receive the combination to see how safe and effective it is. The goal is to impr…

This study tests a combination of two drugs, enasidenib and azacitidine, in about 50 adults with a type of leukemia (AML) that has come back or not responded to prior treatment. Participants must have a specific gene mutation (IDH2). The goal is to see if the combo can shrink or …

This study tests a type of internal radiation called high-dose-rate brachytherapy for people with liver tumors that cannot be surgically removed. The treatment uses a tiny radioactive source placed directly into the tumor to kill cancer cells while sparing nearby healthy tissue. …

This study is testing whether certain breast cancer patients who have an exceptional response to initial drug therapy can safely avoid surgery or radiation. It includes 120 people with specific breast cancer types. The goal is to see if less aggressive treatment can still keep th…

This study tests whether adding venetoclax to ongoing ibrutinib or acalabrutinib treatment can eliminate remaining leukemia cells in people with high-risk chronic lymphocytic leukemia (CLL). Participants must have been on their current therapy for at least 12 months and still hav…

This study tests a combination of two targeted drugs (tagraxofusp and venetoclax) plus chemotherapy for people with a rare and aggressive blood cancer called BPDCN. The goal is to see if this approach can shrink or eliminate the cancer and improve how long patients live without t…

This study tests whether giving belzutifan alone, pembrolizumab alone, or both together before kidney surgery can help control advanced clear cell kidney cancer. About 10 people with locally advanced disease will receive the drugs before partial or total kidney removal. The main …

This early-phase study tests whether the drug tasquinimod, given alone or with ruxolitinib, can help control myelofibrosis (a type of bone marrow cancer). About 33 adults with primary or post-PV/ET myelofibrosis who cannot take or have stopped responding to standard JAK inhibitor…

This study tests whether adding local treatments like surgery or radiation to the immunotherapy drug durvalumab can help control stage III non-small cell lung cancer that has started to grow again after chemoradiation and durvalumab. About 51 adults will receive this combination.…

This study tests whether combining the drug enfortumab vedotin with radiation therapy can help control locally advanced bladder cancer. About 41 adults with urothelial carcinoma of the bladder will receive the treatment. The main goal is to check safety and side effects.

This study tests whether adding local treatments (like radiation or surgery) to the targeted drug lorlatinib helps control advanced ALK-positive non-small cell lung cancer better than lorlatinib alone. About 30 people with this specific type of lung cancer will take lorlatinib fo…

This early-phase trial tests a new treatment made from specially engineered cord blood cells (TROP2-CAR-NK cells) in adults with advanced solid tumors that have not responded to standard therapies. The main goal is to find a safe dose and watch for side effects. Up to 54 particip…

This study tests whether combining two chemotherapy drugs (tretinoin and arsenic trioxide) with a targeted therapy (gemtuzumab ozogamicin) works better than the two drugs alone for adults with a specific type of leukemia called acute promyelocytic leukemia. About 151 newly diagno…

This study tests if a less invasive surgery (laparoscopy) works as well as standard open surgery for people with advanced ovarian, fallopian tube, or peritoneal cancer who have already had chemotherapy. About 580 participants will be randomly assigned to one of the two surgeries.…

This early-phase trial tests a new treatment for colorectal cancer that has spread to the lining of the abdomen. It combines specially engineered natural killer (NK) cells, given both into a vein and directly into the belly, with the drug cetuximab. The goal is to find the safest…

This early-phase study tests a combination of three drugs—nivolumab (an immunotherapy), fluorouracil (chemotherapy), and interferon alpha-2b (an immune stimulant)—in people with a rare type of liver cancer called fibrolamellar carcinoma that cannot be surgically removed. The goal…

This study tests whether adding 1 year of pembrolizumab (an immunotherapy drug) after radiation therapy can better control kidney cancer that has spread to a few spots. About 144 people with this type of cancer will take part. The main goal is to see if the combination is safe an…

This study tests whether adding belantamab mafodotin to standard lenalidomide maintenance therapy after a stem cell transplant can turn residual myeloma cells undetectable in patients with newly diagnosed multiple myeloma. About 94 adults who have already had a transplant and sti…

This study looks at whether giving radiation to the lymph nodes after surgery can lower the chance of melanoma returning in people who are already receiving immunotherapy. About 168 adults with high-risk melanoma that has spread to a sentinel lymph node will take part. The goal i…

This study tests a new treatment for people with autoimmune disorders like systemic sclerosis, lupus, and lupus nephritis. It combines a special immune cell therapy (AD-PluReceptor-NK cells) with a drug called tafasitamab and chemotherapy to try to control the disease. The study …

This early-stage study tests whether stem cells from a healthy donor can help control heart failure in people whose hearts were weakened by anthracycline chemotherapy. About 72 adults with a low heart pumping ability (LVEF 40% or less) will receive either standard care alone or s…

This study is for men with high-risk prostate cancer that hasn't spread far. It tests whether adding the drug niraparib to standard hormone therapy after radiation can keep the cancer from coming back longer. About 200 men will take part, and researchers will track cancer progres…

This study tests whether a combination of three drugs—calaspargase pegol-mknl, decitabine, and venetoclax—can help control relapsed or treatment-resistant T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LLy) in patients aged 1 month to 21 years. T…

This early-phase study tests a new drug called NBTXR3, which is injected into the tumor and activated by radiation therapy, alongside standard chemotherapy. The goal is to find the safest dose and see if it helps control esophageal cancer. About 24 adults with stage II or III eso…

This early-phase trial tests whether combining chemotherapy, radiation, and the immunotherapy drug dostarlimab is safe and tolerable for people with stage IIIC node-positive endometrial cancer. About 21 participants will receive chemoradiation followed by chemotherapy plus dostar…

This study tests whether combining two drugs, dostarlimab and LB-100, can help control ovarian clear cell carcinoma, a rare and aggressive cancer. About 21 adults with recurrent disease will receive the treatment. The main goal is to check safety and side effects, while also seei…

This early-phase study tests a new type of high-dose radiation (HYDRA) for people with laryngeal cancer. The main goal is to find the highest safe dose and check for side effects. About 11 adults with early to moderately advanced laryngeal cancer will take part. The study is run …

This study tests whether two drugs, venetoclax and revumenib, can control minimal residual disease (MRD) in people with acute myeloid leukemia (AML). MRD means small numbers of cancer cells remain after initial treatment, raising the risk of relapse. The trial enrolls about 8 par…

This study tests whether a combination of two drugs, fruquintinib and tislelizumab, can control colorectal cancer in people who still have signs of minimal residual disease (MRD) after completing standard chemotherapy. About 20 adults with stable colorectal cancer and positive ct…

This study tests whether the drug ivonescimab can help control a rare and aggressive form of breast cancer called invasive lobular carcinoma that has spread and no longer responds to hormone therapy. About 29 adults with either hormone-receptor-positive or triple-negative disease…

This early-phase study tests a new treatment called JV-394 for people with T/NK cell lymphoma that has come back or not responded to standard therapy. JV-394 uses the patient's own immune cells, which are modified in a lab to better recognize and attack cancer cells. The main goa…

This early-phase study is testing whether a new drug called SAR445877, when added to standard chemotherapy and a targeted therapy, is safe for people with advanced colorectal cancer that hasn't spread widely yet. About 41 adults will take part. The main goal is to find any side e…

This study tests two drugs, binimetinib and encorafenib, in people with advanced melanoma that has spread to the brain. The drugs block enzymes that help cancer cells grow. The goal is to see if this combination can control the disease and improve survival. About 35 adults with a…

This study tests whether adding the drug venetoclax to standard chemotherapy can better treat acute myeloid leukemia (AML) that is newly diagnosed or has come back. About 116 adults with AML or high-risk MDS will receive the combination. The goal is to see if the combo improves r…

This study tests whether adding the investigational drug NKTR-255 to the standard immunotherapy durvalumab can help restore immune cells after chemoradiation in people with advanced non-small cell lung cancer. About 39 adults will receive the combination and be followed for overa…

This early-phase trial tests a new combination treatment for people with colorectal cancer who have minimal residual disease (MRD) — tiny amounts of cancer left after standard therapy. The treatment uses specially engineered natural killer (NK) cells from donated cord blood, desi…

This early-stage trial tests whether combining two drugs—atezolizumab (which helps the immune system fight cancer) and cabozantinib (which blocks tumor growth)—can safely control recurrent glioblastoma, an aggressive brain cancer that has returned after standard treatment. About …

This early-phase trial aims to find a safe dose of gemcitabine combined with nab-sirolimus for people with advanced leiomyosarcoma or soft-tissue sarcoma that has specific TSC1 or TSC2 gene changes. About 18 participants will receive the drug combination to see how well it is tol…

This study tests a combination of two drugs, azacitidine and pembrolizumab, for people with Hodgkin's lymphoma that has returned or not responded to treatment. The goal is to see if this combo can shrink tumors. About 24 adults will take part in this early-phase trial at a single…

This study tests whether adding naxitamab to the standard drug sacituzumab govitecan is safe and effective for people with metastatic triple-negative breast cancer (TNBC), a type that has spread and is tough to treat. About 31 adults with TNBC will join this early-phase trial to …

This study tests a new drug called puxitatug samrotecan in people with a rare and aggressive type of salivary gland cancer (adenoid cystic carcinoma subtype I). The goal is to see if the drug can shrink or control the cancer. About 28 adults whose cancer has spread or cannot be r…

This study tests a drug called ivonescimab in 90 adults with metastatic colorectal cancer that has already been treated. The goal is to see if the drug can help control the cancer. Participants will receive the drug and be monitored for side effects.

This early-phase trial tests whether adding the drug lurbinectedin to two standard chemotherapy drugs (paclitaxel and bevacizumab) can better control platinum-resistant ovarian cancer. About 34 adults with advanced ovarian, fallopian tube, or peritoneal cancer will receive the co…

This study tests whether adding ASTX727 to the standard drug dasatinib can better control chronic myeloid leukemia (CML) in newly diagnosed patients. About 70 adults with a specific genetic marker (Philadelphia chromosome) will receive both pills. The goal is to see if the combin…

This study tests a combination of drugs for people whose blood cancer (like AML or MDS) has come back or not responded to treatment. Participants must have specific gene changes (IDH1 and another signaling mutation). The goal is to see if the combination is safe and tolerable. Ab…

This early-phase study tests a new combination treatment for people with advanced pancreatic cancer that has spread or cannot be removed by surgery. The treatment uses specially engineered immune cells (NK cells) from donated cord blood, given through a belly infusion and a vein,…

This study tests if adding medication can treat or prevent lymphedema and fibrosis (tissue hardening and swelling) caused by radiation therapy in head and neck cancer survivors. About 250 participants who finished radiation at least 6 months ago and have moderate-to-severe side e…

This early-phase study tests a drug called belantamab mafodotin in 30 people with high-risk smoldering multiple myeloma, a condition that often leads to active cancer. The main goals are to find a safe dose and see how well the drug controls the disease. Participants receive the …

This study tests a combination of four drugs (venetoclax, cladribine, low-dose cytarabine, and azacitidine) in 145 adults aged 50 and older with untreated acute myeloid leukemia (AML). The goal is to see if this mix can destroy leukemia cells and lead to remission. Participants w…

This study tests whether a chemotherapy-free combination of pirtobrutinib and rituximab can help people with low or intermediate risk mantle cell lymphoma achieve long-term remission. About 50 adults who have not yet been treated for MCL will receive the two drugs. The main goal …

This study tests whether specially grown donor immune cells (called cytotoxic T lymphocytes) can safely and effectively fight BK and JC virus infections in 100 people with weakened immune systems, such as those with cancer, HIV, or organ transplants. The cells are made in a lab f…

This study tests whether adding metal-detoxifying drugs (Ca-EDTA and DMSA) to standard chemotherapy can improve outcomes for adults with intermediate- or high-risk acute myeloid leukemia (AML). Researchers believe that lowering metal levels in the blood and bone marrow may help c…

This study tests a combination of three drugs (azacitidine, venetoclax, and gilteritinib) in people with FLT3-mutated acute myeloid leukemia or high-risk myelodysplastic syndrome that has returned or not responded to treatment. The goal is to find the best dose and see if the com…

This study tests whether the drug sacituzumab govitecan can help control salivary gland cancer that has come back or spread. About 30 adults whose cancer cannot be removed by surgery or cured by radiation will receive the drug. Researchers will monitor side effects and tumor resp…

This study tests a new way to give radiation therapy for advanced prostate cancer. Instead of many sessions, patients get just 5 high-dose treatments. The goal is to see if this shorter approach is safe and works well. About 70 people with high-risk prostate cancer will take part…

This study is testing a new treatment approach for adults with a type of blood cancer called B-cell acute lymphoblastic leukemia (ALL). It combines standard chemotherapy with two targeted immunotherapy drugs, blinatumomab and inotuzumab ozogamicin, to see if this mix works better…

This early-phase study tests a new treatment for people with advanced synovial sarcoma or myxoid/round cell liposarcoma. Participants receive donated immune cells (NK cells) that are specially designed to recognize and attack their cancer, along with chemotherapy to prepare the b…

This study tests whether giving focused radiation before surgery for brain metastases works better than giving it after surgery. About 180 adults with cancer that has spread to the brain will be randomly assigned to one of the two timing strategies. The goal is to see which appro…

This study tests whether adding talazoparib to standard hormone therapy and enzalutamide can better shrink prostate cancer that has spread to lymph nodes. About 30 men will take the drug combination before having their prostate removed. The goal is to see if the treatment is safe…

This study tests whether adding the drug BMS-986504 to standard chemotherapy can help control pancreatic cancer in people with a specific genetic change (MTAP deletion). About 60 adults with this type of pancreatic cancer will receive the combination before and after surgery or w…

This study tests whether a diet rich in prebiotic foods can improve how well immunotherapy works in people with advanced melanoma that cannot be removed by surgery. About 75 participants will eat a special diet while starting standard immunotherapy. The goal is to see if the diet…

This study tests an oral chemotherapy drug, decitabine, given alone or with other targeted drugs, to help keep acute myeloid leukemia (AML) under control after it has gone into remission. About 125 adults whose AML is in first remission but who are not ready for a stem cell trans…

This study tests whether two drugs, pembrolizumab and lenvatinib, can shrink brain metastases in people with triple-negative breast cancer, non-small cell lung cancer, or other solid tumors. About 104 participants will receive the combination therapy. The goal is to see how well …

This study is for people with stage IV cancer that has started to slowly grow in a few new spots while on their current treatment. Researchers want to see if treating those new spots directly with radiation, surgery, or other local methods, while continuing the same drug, works b…

This early-phase trial tests a new treatment called attIL12-TIL for people with advanced or metastatic soft tissue and bone sarcoma. The therapy uses a patient's own tumor-fighting immune cells, modified to better target and attack cancer. The study first finds a safe dose, then …

This study tests whether alternating two different drug combinations can help control higher-risk myelodysplastic syndrome (MDS) and chronic myelomonocytic leukemia (CMML). About 60 adults whose cancer has not responded to or has returned after standard treatment will receive one…

This early-phase study tests a chemotherapy drug (gemcitabine) given as a mist to breathe in. It is for people whose solid tumors have spread to the lungs and who have no standard treatment options. The main goal is to find the safest dose and watch for side effects. Up to 44 par…

This study tests if a very low dose of radiation (4 Gy) can control marginal zone lymphoma, a slow-growing blood cancer. Participants first get the low dose, and if the tumor shrinks enough, they may avoid higher doses. The goal is to reduce side effects while still controlling t…

This early-phase study tests a new treatment for people with advanced pancreatic cancer that has spread and has a specific mutation called KRAS G12D. The treatment uses tiny particles called exosomes to deliver a molecule that blocks the mutated gene. The goal is to find the best…

This study looks at whether adding a prebiotic-rich diet to standard immunotherapy (ipilimumab and nivolumab) can improve the immune response in people with melanoma that can be removed by surgery. About 35 adults with stage III or IV melanoma will follow the diet and take the dr…

This study is for people with brain metastases that have spread from other cancers. It tests whether adding precise radiation (stereotactic radiosurgery) after initial drug therapy can better control brain disease. About 316 adults will be enrolled to see if this combined approac…

This study tests the safety of a drug called olutasidenib given after a stem cell transplant to people with certain blood cancers (like AML or MDS) that have an IDH1 mutation. About 31 participants will take the drug as maintenance therapy to try to keep the cancer from coming ba…

This study is for people with acute myeloid leukemia (AML) that has a specific genetic change called IDH1. It tests a combination of three drugs: decitabine, venetoclax, and olutasidenib. The goal is to find a safe dose and see how well the drugs work together. About 78 adults wi…

This study tests whether inhaling a drug called tranexamic acid can help cancer patients who have severe lung bleeding and are on a breathing machine. The goal is to see if it lowers the chance of death within 28 days compared to standard care. About 60 adults with blood cancers …

This study tests whether adding an immunotherapy drug (obinutuzumab) early to a two-drug combo (acalabrutinib and venetoclax) can better control chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) that is high-risk, has returned, or stopped responding to treatm…

This study tests a new treatment for people with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) that has come back or not responded to standard therapy. The treatment uses specially engineered natural killer (NK) cells designed to recognize and attack cancer cells…

This study tests whether adding special cells from donated umbilical cord blood to a standard drug (ruxolitinib) can better control severe graft-versus-host disease (GVHD) that hasn't improved with steroids. GVHD is a serious condition where donor immune cells attack the patient'…

This study tests whether a cord blood transplant, given after a special conditioning therapy, can help control high-risk blood cancers in people whose disease returned after an earlier stem cell transplant. About 35 participants aged up to 60 will receive the treatment and be mon…

This study tests whether shorter courses of radiation to the lymph nodes can be as safe and effective as standard longer schedules for people with breast cancer who have had surgery. About 768 participants who had a lumpectomy or mastectomy and are at higher risk of the cancer co…

This study tests a new combination of two drugs (REGN5678 and cemiplimab) in men with advanced prostate cancer that has spread and is no longer responding to standard treatments. The main goal is to find the safest dose and understand side effects. About 60 participants will take…

This early-stage study tests a drug called talazoparib combined with radiation therapy for people whose gynecologic cancers (ovarian, endometrial, cervical, and others) have returned after prior treatment. The goal is to find the safest dose and see if the combination can shrink …

This study tests whether giving chemotherapy, immunotherapy (atezolizumab), and radiation before surgery can help prevent soft tissue sarcoma from coming back. About 50 adults with high-risk, removable sarcomas will receive this combination, followed by surgery and more immunothe…

This study tests whether the drug letermovir can prevent the reactivation of cytomegalovirus (CMV) in people who have received a type of cell therapy called axicabtagene ciloleucel. About 36 adults who are CMV-positive and scheduled for this cell therapy will take letermovir. The…

This study tests whether a combination of three drugs (nivolumab, ipilimumab, and cabozantinib) can help people with kidney cancer that has spread to the brain. The goal is to see if the treatment can keep brain tumors from growing. The study involves 20 adults who have not had t…

This study tests a combination of four drugs (mosunetuzumab, polatuzumab, tafasitamab, and lenalidomide) in people with relapsed B-cell non-Hodgkin lymphoma. The goal is to see if this mix can shrink or control the cancer. About 36 adults with follicular lymphoma or diffuse large…

This study tests the safety and best dose of bendamustine, given with or without cyclophosphamide, to prevent graft-versus-host disease (GVHD) in 25 blood cancer patients receiving a stem cell transplant. GVHD occurs when donor cells attack the patient's body. The approach combin…

This study looks at whether stopping a CMV prevention drug (letermovir) based on a patient's immune system response can better protect stem cell transplant patients from CMV infection than taking the drug every day. About 105 participants who have had a stem cell transplant and a…

This early-stage study tests a drug called nivolumab, given both through a vein and directly into the fluid around the spine, for people with melanoma or lung cancer that has spread to the lining of the brain (leptomeningeal disease). The goal is to find the safest dose and see i…

This study tests a drug called AMB-05X in 15 people with colorectal cancer who have completed all curative treatments and show no visible tumors on scans, but still have cancer DNA in their blood. The goal is to see if the drug can safely eliminate these hidden cancer cells and p…

This early-phase study tests a combination of two chemotherapy drugs (hyper-CVAD and venetoclax) in 22 children and young adults whose acute leukemia has returned or not responded to standard treatment. The main goal is to find a safe dose and monitor side effects. Participants m…

This study tests a combination of three drugs (177Lu girentuximab, cabozantinib, and nivolumab) in people with advanced clear cell kidney cancer who have not had prior treatment. The goal is to see if the combination can control the cancer and to check for side effects. About 100…

This early-phase trial tests a new drug called nadunolimab combined with standard treatments (azacitidine, with or without venetoclax) in 40 adults with high-risk myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML). The goal is to see if the combination is safe and to …

This early-stage trial tests whether adding the HIV drug nelfinavir to standard chemotherapy (cisplatin) and radiation can safely treat advanced vulvar cancer that cannot be surgically removed. About 25 adults with stage II–IVA vulvar cancer will receive the combination to find t…

This study tests a drug called zanidatamab in 20 people with early-stage HER2-positive breast cancer. The goal is to see if the drug can make the cancer disappear before surgery. Participants will receive the drug and then have surgery to check if any cancer remains.

This study tests if injecting the cancer drug nivolumab directly into high-risk precancerous mouth lesions can stop them from turning into cancer. About 45 adults with these lesions will receive either the drug or a placebo injection. The goal is to see if the treatment is safe a…

This early-phase study tests a new treatment for advanced head and neck cancer that has stopped responding to standard therapies. The treatment uses specially engineered natural killer (NK) cells from donated cord blood, designed to better target cancer cells and resist the tumor…

This study is testing whether people with stage II-III rectal cancer can safely avoid surgery by closely monitoring their tumor after chemotherapy and radiation. Instead of immediate surgery, participants will be watched for any signs of regrowth. The goal is to see if this appro…

This early-phase study tests a new drug, ulixertinib, combined with cetuximab and/or encorafenib in people with advanced colorectal cancer that has spread and hasn't responded to prior treatments. The main goal is to find the safest dose and check for side effects. About 27 parti…

This study combines a targeted antibody-drug (inotuzumab ozogamicin) with low-intensity chemotherapy to treat adults with acute lymphoblastic leukemia (ALL). The goal is to find the best dose and see if the combination improves survival and remission rates. Participants include o…

This study tests a cream called tofacitinib for people with early-stage cutaneous T-cell lymphoma (CTCL), a rare skin cancer. The cream is applied to the skin to see if it can safely control the disease. About 20 adults with stage IA, IB, or IIA CTCL will take part.

This study tests whether giving standard chemotherapy (doxorubicin and trabectedin) after surgery can help people with early-stage uterine leiomyosarcoma stay cancer-free longer. About 48 participants who had their tumor fully removed will receive the treatment. The goal is to se…

This study tests whether adding the targeted drug sotorasib to standard chemotherapy before surgery can shrink tumors more effectively in people with a specific type of lung cancer (KRAS G12C mutation). About 27 adults with stage IIA to IIIB non-squamous lung cancer will receive …

This study tests a drug called avapritinib in people with advanced solid tumors that have certain genetic changes (CKIT or PDGFRA mutations). The goal is to see if the drug can shrink or control the cancer. About 50 adults with cancers like melanoma, sarcoma, or breast, lung, or …

This study tests a combination of two or three drugs (ivosidenib, venetoclax, with or without azacitidine) in people with blood cancers like leukemia that have a specific IDH1 mutation. The goal is to find the best dose and see how well the drugs work together to stop cancer grow…

This study tests a drug called NBTXR3 given with radiation therapy for people with locally-advanced non-small cell lung cancer who cannot have chemotherapy or surgery. The goal is to see if the combination is safe and helps control the cancer. About 40 adults with stage I to III …

This study tests whether combining two oral drugs, pirtobrutinib and venetoclax, can control mantle cell lymphoma (MCL) in patients whose cancer has come back or hasn't responded to prior treatments. About 30 adults with confirmed MCL will take these pills to see how many achieve…

This study tests a drug called olutasidenib in people with certain early blood conditions (CCUS, lower-risk MDS, or CMML) that have a specific IDH1 gene change. The goal is to see if the drug can control the disease and is safe. About 15 participants will take the drug and be mon…

This early-phase study tests a combination of three drugs (decitabine, lisaftoclax, and olverembatinib) in 30 adults with advanced chronic myeloid leukemia or a related acute leukemia. The goal is to find safe doses and see if the combo can control the disease in people who have …

This phase 3 trial tests whether a multi-disciplinary treatment plan can help people with pancreatic cancer that has spread to only a few other places in the body live longer without the disease getting worse. About 80 adults with this condition will receive either standard care …

This study combines three chemotherapy drugs (cladribine, idarubicin, cytarabine) with a targeted drug (quizartinib) to treat acute myeloid leukemia (AML) and high-risk myelodysplastic syndrome (MDS). It includes up to 80 adults who are newly diagnosed or whose cancer has returne…

This study tests a two-step treatment for people with high-risk mantle cell lymphoma (MCL) who have not been treated before. First, patients receive a combination of targeted therapy (BTKi) and an antibody (rituximab). Then, they get a newer antibody drug (glofitamab) to help con…

This study is for men with prostate cancer who have detectable PSA levels after prostate removal surgery. It tests a personalized approach using the drug apalutamide alongside radiation therapy to see if it can reduce fatigue and other side effects compared to standard care. The …

This early-phase study tests the safety of an engineered virus called M032 in 20 children and adults with diffuse midline glioma, a rare and aggressive brain tumor. Participants receive the virus directly into the tumor after completing standard radiation therapy. The goal is to …

This study tests adding an experimental drug called CTX-009 to standard chemotherapy (gemcitabine and cisplatin) plus an immunotherapy (durvalumab) as a first treatment for people with advanced bile duct cancer that cannot be removed by surgery. The goal is to see if this combina…

This study tests a drug called REGN5678 in men with high-risk prostate cancer who will later have their prostate removed. The goal is to check the drug's safety and how it affects the cancer before surgery. About 42 men will take part in this early-phase trial at MD Anderson Canc…

This study tests whether combining two drugs, blinatumomab and asciminib, can better control Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) in adults. It is for patients who cannot have or have had little prior chemotherapy. The main goal is to check safe…

This study tests whether giving patients their own personalized natural killer (NK) cells after chemotherapy and a cord blood transplant can help kill leftover cancer cells and reduce the risk of graft-versus-host disease. It includes 100 adults with various blood cancers like le…

This study tests whether two drugs, zanzalintinib and pembrolizumab, can help control advanced soft-tissue sarcoma that has spread. About 20 adults with specific sarcoma types will receive the combination. The main goal is to check safety and see if the treatment slows tumor grow…

This study tests a combination of two drugs, CPX-351 and ivosidenib, in about 30 adults with a specific genetic form of acute myeloid leukemia or high-risk myelodysplastic syndrome. The goal is to see if the combo can shrink or control the cancer. Participants must have the IDH1 …

This study is for children whose acute myeloid leukemia (AML) has come back or not responded to treatment. Researchers are testing a combination of two oral drugs, venetoclax and ASTX727, to find the best dose and see how safe it is. About 40 children will take part in this early…

This study tests an experimental drug called nirogacestat in 40 adults with desmoid tumors (also called aggressive fibromatosis). The goal is to see if the drug is safe and how it affects the tumors. Researchers will monitor side effects and tumor response. This is a Phase 2 tria…

This study tests whether the drug ubamatamab, alone or with cemiplimab, can control rare cancers like renal medullary carcinoma and epithelioid sarcoma. About 40 adults with advanced or spreading tumors that lack the SMARCB1 protein will receive the treatment. The goal is to see …

This study tests a new treatment using specially engineered immune cells (TROP2 CAR-NK) delivered directly into the abdomen. It is for people with ovarian or pancreatic cancer that has not responded to standard treatments. The goal is to find a safe dose and see if it can help co…

This early-phase study tests a new three-drug combination for children and young adults (ages 2–21) with acute leukemia that has returned or not responded to treatment. The goal is to find the safest dose of ziftomenib when given with venetoclax and azacitidine. Only patients wit…

This study tests whether two drug combinations—pentoxifylline with vitamin E, or pravastatin alone—can prevent or reduce lymphedema (swelling) and fibrosis (scarring) caused by radiation therapy in head and neck cancer patients. About 295 adults who are about to receive radiation…

This study is for people with acute myeloid leukemia (AML) that has come back or not improved with standard treatments. It tests a combination of three drugs: a chemotherapy pill (ASTX727), a targeted therapy (venetoclax), and another targeted drug (ivosidenib or enasidenib) base…

This study tests whether adding a third drug (relatlimab) to a standard two-drug combination (nivolumab and ipilimumab) works better for advanced kidney cancer that hasn't been treated before. About 15 adults with stage IV clear cell kidney cancer will receive either the three-dr…

This early-phase study tests a new treatment for advanced clear cell kidney cancer that has stopped responding to standard therapies. The treatment uses specially engineered immune cells (CAR NK cells) from a healthy donor that are designed to target and kill cancer cells while r…

This study is collecting information on the safety and effectiveness of placing a stent in the portal vein of people with gastrointestinal cancer who have a narrowed vein. The goal is to see how long the stent keeps the vein open and how it affects patients' overall well-being, i…

This study tests whether combining two antiviral drugs, baloxavir and oseltamivir, works better than oseltamivir alone for severe flu in people who have had a stem cell transplant or have blood cancer. About 60 participants will be followed for 30 days to see if the combo reduces…

This early-phase study tests a wearable device that creates electric fields (tumor treating fields) combined with either cabozantinib or a chemo-immunotherapy pair (nab-paclitaxel and atezolizumab) in people with advanced solid tumors in the abdomen or chest. The goal is to find …

This early-phase trial is testing whether adding natural killer (NK) cells from a healthy donor to the drugs azacitidine and venetoclax can help control acute myeloid leukemia (AML) in adults whose cancer has returned or not responded to treatment. About 32 participants will rece…

This study tests whether a combination of three drugs (avutometinib, defactinib, and cetuximab) can help control advanced colorectal cancer that no longer responds to standard anti-EGFR therapy. About 33 adults with unresectable, anti-EGFR-refractory cancer will receive the drugs…

This study compares two drug combinations to prevent graft-versus-host disease (GVHD) in people aged 65 and older with certain blood cancers who receive a stem cell transplant. Participants will receive either cyclophosphamide, sirolimus, and MMF or cyclophosphamide, sirolimus, a…

This study tests a combination of targeted drugs and immunotherapy for people with untreated primary mediastinal large B-cell lymphoma (PMBL), a rare type of blood cancer. The treatment uses brentuximab vedotin (which delivers a toxin directly to cancer cells) and nivolumab (whic…

This study tests a new all-oral combination of drugs for people with acute myeloid leukemia (AML) or related blood cancers. The goal is to find a safe dose and see if the combo can control the disease. It includes 43 participants aged 12 and older who cannot have standard high-do…

This early-phase study tests two oral drugs, ziftomenib and quizartinib, together in adults with relapsed or hard-to-treat acute myeloid leukemia (AML). The goal is to find a safe and effective all-pill treatment for the most common AML subtypes. About 44 participants will take t…

This study tests whether adding celecoxib to TAS-102 can clear tiny bits of cancer DNA (ctDNA) from the blood of colorectal cancer patients who have finished standard chemotherapy. About 25 adults with no visible tumors but positive ctDNA tests will receive TAS-102 alone or with …

This early-phase study tests a combination of two drugs, pembrolizumab and lenvatinib, in 15 people with advanced stomach or gastroesophageal cancer that has spread or cannot be surgically removed. The goal is to see if the combo can shrink tumors by boosting the immune system an…

This study tests a new treatment for people with myeloid blood cancers (like leukemia) that have come back or not responded to standard therapy. The treatment uses specially engineered immune cells from donated cord blood, designed to better target and kill cancer cells while res…

This study tests a drug called ponatinib in 50 adults with chronic myeloid leukemia (CML) whose cancer did not respond to or they could not tolerate other targeted therapies. The goal is to see if ponatinib can control the disease by blocking a protein that helps cancer cells gro…

This study tests a drug called emapalumab to see if it can safely help people whose blood cell counts stay dangerously low after CAR T-cell therapy for certain lymphomas. About 32 adults who have already received standard CAR T-cell therapy will take part. The goal is to find out…

This study tests whether fecal microbiota transplantation (FMT) can reduce gut-related side effects from antibiotics in 40 adults with B-cell lymphoma who are receiving standard CAR-T cell therapy. Participants will receive FMT alongside their cancer treatment to see if it improv…

This study tests a new, more precise way to destroy liver tumors using a combination of stereotactic guidance, special CT imaging, and computer software. The goal is to ensure the entire tumor is treated with a safe margin of healthy tissue. About 50 adults with up to 5 small liv…

This study tests whether a drug called dexrazoxane can protect the heart from damage caused by chemotherapy in people with certain blood cancers, like acute myeloid leukemia and high-risk myelodysplastic syndrome. About 100 participants will receive the drug alongside standard ch…

This study tests a drug called revumenib in people with certain types of leukemia that have high levels of HOX genes. The goal is to see if the drug can help control the cancer. About 40 people aged 12 and older with leukemia that has come back or not responded to treatment can j…

This study tests if the drug elranatamab, given before and after a stem cell transplant, can better control high-risk multiple myeloma. About 40 adults with newly diagnosed, high-risk disease will receive the drug to reduce cancer cells before transplant and then as maintenance t…

This early-phase trial tests a new treatment called Attil12-T cell therapy for people with advanced soft tissue or bone sarcoma that has spread or cannot be removed. The therapy uses a patient's own immune cells, modified to target and attack the tumor. The main goals are to find…

This early-phase study tests a drug called HC-7366 in 18 adults with acute myeloid leukemia (AML) that has come back or not responded to treatment. The main goal is to find a safe dose and check for side effects. Researchers will also watch for any signs that the drug helps contr…

This early-phase trial tests a new approach for people with recurrent high-grade glioma, an aggressive brain cancer. Researchers use a modified cold virus (DNX-2401) loaded into stem cells and injected into an artery to target and attack tumor cells. The main goals are to find th…

This study is testing a combination of four chemotherapy drugs (cladribine, idarubicin, cytarabine, and venetoclax) in about 500 people with acute myeloid leukemia, high-risk myelodysplastic syndrome, or a fast-growing form of chronic myeloid leukemia. The goal is to see how well…

This study tests whether adding radiation therapy to a CAR T-cell drug (axicabtagene ciloleucel) can safely treat follicular lymphoma that has come back or not responded to at least two prior treatments. About 20 adults will receive the combination and be monitored for side effec…

This early-phase trial tests the safety and effectiveness of pembrolizumab, an immunotherapy drug, in people with thymoma or thymic carcinoma that cannot be surgically removed. The drug helps the immune system attack cancer cells. About 37 adults with advanced thymus gland cancer…

This study tests whether adding the immunotherapy drug pembrolizumab to standard chemotherapy (cisplatin and gemcitabine) before and after surgery can improve long-term results for people with a type of bile duct cancer called intrahepatic cholangiocarcinoma. About 24 adults with…

This study tests a combination of chemotherapy drugs (mini-Hyper-CVD) plus three targeted drugs (rituximab, inotuzumab ozogamicin, and blinatumomab) in children and young adults whose B-cell acute lymphocytic leukemia has come back or not responded to treatment. The goal is to se…

This study tests a combination of five drugs for people newly diagnosed with a specific type of acute myeloid leukemia (AML) or high-risk myelodysplastic syndrome (MDS). The goal is to see how well the treatment kills cancer cells and what side effects occur. About 270 participan…

This study tests a combination of two drugs, CPX-351 and venetoclax, in adults with acute myeloid leukemia (AML) that has come back or not responded to prior treatment. The goal is to see if this combination can stop cancer growth and achieve remission. About 52 participants will…

This early-phase study tests whether a specially engineered virus called G207 is safe for children whose cerebellar brain tumors have come back or not responded to standard treatments. Up to 24 children aged 3 to 21 will receive the virus directly into the tumor, along with a low…

This early-phase study tests whether adding a new drug (HC-7366) to standard immunotherapy (nivolumab with or without ipilimumab) can help control advanced clear cell kidney cancer. About 35 adults with stage IV disease will participate. The main goal is to check safety and side …

This early-phase study tests a new treatment called JV-213 for people with B-cell lymphoma that has returned or not responded to standard therapies. JV-213 uses a patient's own immune cells, modified to attack cancer cells. The main goal is to find the safest dose and monitor sid…

This study tests a new drug called golidocitinib, given alone or with standard chemotherapy (CHOP), for people newly diagnosed with peripheral T-cell lymphoma, a rare blood cancer. The goal is to see if the drug helps control the disease safely. About 30 adults will take part at …

This study tests a drug called canakinumab in people with low- or intermediate-risk myelodysplastic syndromes (MDS) or chronic myelomonocytic leukemia (CMML). The drug is a lab-made antibody that may help slow cancer growth and improve blood cell counts. About 76 adults will rece…

This study tests a shorter, higher-dose radiation schedule (hypofractionated) for people with Merkel cell carcinoma, a rare skin cancer. About 52 participants who have had surgery but no distant spread will receive radiation to the tumor site and nearby lymph nodes. The goal is t…

This study tests whether giving radiation therapy before starting immunotherapy can help people with rare sinonasal or anorectal melanoma. About 40 adults with no distant spread will receive the combination. The main goal is to see how well the tumor responds before surgery.

This study tests whether a combination of three drugs—pirtobrutinib, venetoclax, and obinutuzumab—can control relapsed chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). About 40 adults who have had prior treatment will receive this time-limited therapy. The …

This study tests a combination of two drugs—enasidenib (a targeted pill) and azacitidine (a chemotherapy-like drug)—in people with a high-risk blood cancer called myelodysplastic syndrome (MDS) that has a specific IDH2 gene mutation. The goal is to see if the combo is safe and ca…

This study tests a drug called ivonescimab in 24 people with advanced cutaneous squamous cell carcinoma that cannot be removed by surgery or has spread. The goal is to see if the drug can help control the cancer and to check for side effects. Participants will receive the drug an…

This study tests a combination of three drugs (ASTX727, venetoclax, and gilteritinib) for people with acute myeloid leukemia or high-risk myelodysplastic syndrome that has a specific gene change called FLT3. The goal is to find the best dose and see how well the drugs work togeth…

This study tests a combination of two drugs, gilteritinib and momelotinib, for adults with a specific type of acute myeloid leukemia (AML) that has come back or not responded to treatment. The main goal is to find the safest dose of momelotinib when given with gilteritinib. About…

This early-phase study tests a new drug called CBP-1019 combined with standard chemotherapy or other targeted therapies in people with advanced solid tumors that have stopped responding to treatment. The goal is to find the safest dose and see if the combination can shrink tumors…

This early-stage study is testing a combination of two drugs, alpelisib and pembrolizumab, in people with metastatic breast cancer or melanoma that has spread. The main goal is to find a safe dose and understand side effects. About 50 adults whose cancer has progressed after stan…

This early-phase study tests a new type of cell therapy for people with advanced melanoma that has not responded to standard treatments. The therapy uses a patient's own immune cells (NK cells) that are engineered in the lab to recognize and attack a protein called PRAME found on…

This study is for people whose brain metastases have returned after initial radiation. It combines either laser ablation or surgery with a second round of targeted radiation. The goal is to control the disease and monitor side effects in 155 participants.

This study is testing a combination of six chemotherapy drugs in people whose acute lymphoblastic leukemia, lymphoblastic lymphoma, or related blood cancers have returned or stopped responding to treatment. The goal is to see how well this drug cocktail works and what side effect…

This study tests a pill called larotrectinib in people with advanced solid tumors that have too many copies of the NTRK gene. The drug works by blocking enzymes that help cancer cells grow. About 13 participants will take the drug to see if their tumors shrink or stop growing.

This early-stage trial tests whether genetically modified immune cells (called CTLs) can safely control viral infections like CMV, BK virus, or COVID-19 in cancer patients with weakened immune systems. The cells are designed to attack only the specific virus each patient has. The…

This study tests a new device that uses very short electric pulses to destroy small thyroid tumors without cutting the skin. It is for people with early-stage papillary thyroid cancer that has not spread. The goal is to see if this treatment is safe and can control the disease.

This study tests whether giving the chemotherapy drug paclitaxel before and after stomach surgery can help control gastric cancer that has spread to the lining of the abdomen. About 30 adults with this condition will receive the drug directly into the abdomen and through a vein, …

This study tests a drug called brentuximab vedotin for people with a rare type of chest cancer (CD30+ mesothelioma) that cannot be removed with surgery. The drug works like a smart bomb, targeting a specific marker on cancer cells to stop them from growing. About 55 adults will t…

This study tests whether the drug belzutifan can help control metastatic clear cell kidney cancer in people who are currently being watched without treatment. About 78 adults with slow-growing cancer that has spread will either receive belzutifan or continue monitoring. The goal …

This study tests whether matching smoking cessation treatments—like nicotine patches, counseling, or medications—to a person's unique traits can help them quit. About 2,010 smokers who want to quit will receive personalized care. The goal is to find better ways to help people sto…

This study tests whether adding isatuximab to the standard drug lenalidomide can better control high-risk multiple myeloma after a stem cell transplant. About 61 adults aged 18 to 72 with newly diagnosed high-risk myeloma will receive the combination as maintenance therapy. The m…

This study tests whether a combination of three drugs (adagrasib, cetuximab, and cemiplimab) can help control metastatic colorectal cancer in people whose tumors have a specific KRAS G12C mutation. About 31 adults who have already tried at least one prior treatment will receive t…

This early-phase study tests a new drug called IACS-6274, given alone or with other medicines, in people with advanced solid tumors (like certain melanomas, ovarian, or uterine cancers). The main goal is to find the safest dose and understand side effects. About 54 adults will ta…

This study tests a combination of two drugs, blinatumomab and ponatinib, along with standard chemotherapy, in people with a specific type of acute lymphoblastic leukemia (ALL) that has a genetic change called the Philadelphia chromosome. The goal is to see if this mix can better …

This study tests a drug called loncastuximab tesirine (lonca) in people with large B-cell lymphoma that did not fully respond to CAR T-cell therapy. The goal is to see if lonca can turn a partial response into a complete response and help control the disease. About 30 adults will…

This study is for people with esophageal or stomach cancer that has spread to 3 or fewer places in the body. It compares standard chemotherapy alone to chemotherapy plus radiation or surgery to the main tumor and those spots. The goal is to see if adding local treatment helps peo…

This study tests whether adding a second cream (calcipotriene) to the standard treatment (fluorouracil) works better for people with multiple actinic keratoses—rough, scaly patches caused by sun damage that can turn into skin cancer. About 30 adults will apply one of the two crea…

This study tests a new treatment called KSQ-004EX for people with advanced solid tumors that have not responded to standard therapies. The treatment uses a patient's own immune cells (tumor infiltrating lymphocytes) that are genetically modified to be more powerful against cancer…

This study tests whether combining a very low dose of radiation to the whole skin with a targeted drug called brentuximab vedotin can better control mycosis fungoides, a rare type of skin lymphoma. About 30 adults with stages I to IV disease whose cancer has come back or not resp…

This study tests whether ultra low dose radiation can control skin lesions in people with mycosis fungoides, a rare type of lymphoma. About 50 participants will receive targeted radiation to their skin lesions. The goal is to shrink or control the lesions while reducing side effe…

This study tests whether combining two drugs—atezolizumab (helps the immune system fight cancer) and cabozantinib (blocks cancer growth)—can control osteosarcoma that has returned or spread. About 40 adolescents and young adults (age 12+) whose cancer did not respond to standard …

This study tests whether a combination of three drugs—cladribine, low-dose cytarabine, and decitabine—can help control acute myeloid leukemia (AML) or high-risk myelodysplastic syndrome (MDS) in people aged 60 and older. Participants receive the drugs in cycles to stop cancer cel…

This study tests whether giving high doses of ruxolitinib and busulfan before a stem cell transplant can reduce spleen size and help the transplant work better in people with myelofibrosis. About 30 adults aged 18 to 75 with an enlarged spleen and a matched donor will take part. …

This study is for people with breast cancer who need a mastectomy (breast removal) followed by immediate breast reconstruction using their own tissue. It compares two ways of giving radiation before surgery: the standard longer course versus a shorter course with fewer, higher do…

This study tests a drug called ivonescimab in people with advanced clear cell kidney cancer that has spread or cannot be removed. Participants must have already tried at least one other treatment, including a type of immunotherapy. The goal is to see if ivonescimab can help contr…

This early-phase study tests a chemotherapy drug combo (CPX-351) in about 38 adults with high-risk myelodysplastic syndrome or chronic myelomonocytic leukemia that came back or didn't respond to standard treatment. The main goals are to find the safest dose and check for side eff…

This study tests a new treatment for people with multiple myeloma that has come back or not responded to standard therapy. The treatment uses immune cells (NK cells) from donated cord blood that are genetically modified to recognize and attack myeloma cells. The goal is to find a…

This early-phase study tests a new drug combination (ziftomenib, venetoclax, and gemtuzumab) in children and young adults aged 3 to 21 with acute myeloid leukemia that has come back or not responded to treatment. The main goal is to find a safe dose and check for side effects. Th…

This study tests whether adding the immunotherapy drug pembrolizumab to standard chemotherapy can shrink tumors better than chemotherapy alone in people with advanced squamous cell cancer of the nasal cavity or sinuses. About 35 adults with newly diagnosed, untreated stage II to …

This study tests an oral drug called ONC201 in 120 adults whose acute leukemia or high-risk myelodysplastic syndrome (MDS) has returned or stopped responding to standard treatments. The goal is to find the safest dose and see if the drug can shrink or control the cancer. ONC201 w…

This study tests a CAR T-cell drug called brexucabtagene autoleucel in 40 adults with B-cell acute lymphocytic leukemia that has come back or is hard to treat. Participants first receive standard chemotherapy drugs to reduce cancer, then get the CAR T-cells. The goal is to see if…

This study tests whether combining two drugs (atezolizumab and tiragolumab) before bladder removal surgery can help control the cancer. It is for people with high-risk bladder cancer who cannot receive standard chemotherapy. The trial is currently recruiting 10 participants.

This study tests a new combination of three drugs (eribulin, irinotecan, and temozolomide) in children and young adults up to age 25 whose solid tumors have come back or not responded to treatment. The main goal is to find the safest dose of eribulin when given with the other two…

This study tests whether two drugs, tivozanib and nivolumab, can control advanced non-clear cell kidney cancer. About 48 adults with this rare cancer type will receive the combination. The goal is to see if the treatment is safe and helps keep the disease from growing.

This study tests whether a family-centered program can help Black prostate cancer survivors and their caregivers eat better, be more active, and feel better overall. About 648 survivor-caregiver pairs will join, with some receiving the family program, some the survivor-only progr…

This study tests if surgery plus heated chemotherapy (HIPEC) can help women whose mucinous ovarian cancer has come back. About 30 participants will get this combined treatment. The goal is to see how long they live without the cancer growing again.

This study tests whether adding chemotherapy (cisplatin and etoposide) to standard mitotane therapy works better than mitotane alone after surgery for adrenal cancer that is likely to come back. About 240 adults with stage I-III adrenal cancer at high risk of recurrence will be r…

This study tests a procedure called radiofrequency ablation (RFA) for people whose parathyroid cancer has come back after surgery and who cannot have another operation. RFA uses heat from a needle to destroy the tumor, aiming to lower high calcium levels that can cause serious he…

This study tests a drug called zanzalintinib in people with advanced bone sarcomas that cannot be removed by surgery or have spread. About 70 adults with osteosarcoma, Ewing sarcoma, chondrosarcoma, or other bone sarcomas will take the drug to see if it can shrink or control the …

This early-stage trial tests a new drug called Peposertib combined with radiation and chemotherapy for people with a fast-growing brain cancer (glioblastoma). The goal is to find the best dose and see if the drug can reach the brain to help kill tumor cells. About 29 adults with …

This study tests whether adding the drug epcoritamab to a standard, gentler chemotherapy mix (R-miniCVP) can help control newly diagnosed diffuse large B-cell lymphoma in older or frail adults who cannot tolerate stronger chemo. About 40 participants will receive the combination …

This study tests whether low-dose sirolimus can safely improve blood cell function in adults with RUNX1 familial platelet disorder, a genetic condition that raises bleeding and leukemia risks. Six participants will take sirolimus and be monitored for side effects and changes in b…

This study tests a drug called asciminib in people with chronic myeloid leukemia (CML) whose first treatment did not work well or caused side effects. About 40 adults will take asciminib to see if it can bring their cancer under control again. The goal is to measure how many achi…

This study tests a drug called ivonescimab in 45 adults whose glioblastoma brain tumor has come back after standard treatment. Phase 1 finds the best dose with fewest side effects; Phase 2 checks if that dose can control the cancer. The goal is to manage the disease, not cure it.

This early-stage trial tests genetically engineered natural killer (NK) cells in 25 people with recurrent glioblastoma, an aggressive brain cancer. The cells are designed to resist the tumor's defenses. The main goal is to find a safe dose and check for side effects, while also w…

This study tests a chemotherapy drug called paclitaxel, given directly into the abdominal cavity, for people with appendiceal cancer that has spread within the abdomen. The goal is to find a safe dose and monitor side effects. About 39 adults whose cancer cannot be removed by sur…

This study is for people with colorectal cancer that has spread to the liver and cannot be removed right away because the healthy part of the liver is too small. Doctors will use a treatment called Y-90 radioembolization to deliver radiation directly to the tumor side of the live…

This study tests whether a blood test that looks for tumor DNA (ctDNA) after liver surgery can help doctors decide who needs more chemotherapy. About 120 adults with colorectal cancer that spread to the liver will get chemotherapy based on their ctDNA results. The goal is to see …

This early-phase study is testing whether drugs that remove excess metals from the body can help control acute myeloid leukemia (AML) and related blood cancers. Researchers want to see if lowering metal levels in the bone marrow and blood can improve how well chemotherapy works. …

This study is for people with locally advanced rectal cancer. It tests whether adding the antibiotic metronidazole to standard therapy can lower levels of certain bacteria in the tumor. The goal is to see if this makes the standard treatment work better. About 60 adults will take…

This study tests whether adding venetoclax to standard chemotherapy before a stem cell transplant can help people with high-risk acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). About 324 adults aged 18-70 will receive the drug combination to see if it improves sur…

This study tests a new approach for people with advanced solid tumors that have spread to the lungs or liver. It combines a drug called NBTXR3, which makes cancer cells more sensitive to radiation, with radiation therapy and an immunotherapy drug (anti-PD-1/L-1) that helps the im…

This study tests whether adding low-dose radiation to the drug elranatamab can better kill cancer cells in people with multiple myeloma that has come back or not responded to treatment and has spread outside the bone. About 34 adults will receive the combination. The goal is to s…

This study tests a drug called luspatercept in 40 adults with lower-risk myelodysplastic syndromes (MDS), a bone marrow condition that often requires frequent blood transfusions. The goal is to see if luspatercept can reduce the number of transfusions needed. Participants will re…

This study tests a new treatment using donated immune cells (NK cells) that are engineered to target a protein called CD70 found on cancer cells. The cells are given after chemotherapy that lowers the body's immune defenses. The goal is to find a safe dose and see if it helps con…

This study tests a mix of drugs to treat aplastic anemia and low-risk myelodysplastic syndrome (MDS), conditions where the bone marrow doesn't make enough blood cells. The treatment uses horse-derived antibodies to kill certain immune cells, plus other drugs to suppress the immun…

This early-stage trial tests a precise type of proton radiation for children with ependymoma, a brain tumor. The therapy is designed to kill cancer cells while reducing damage to healthy brain tissue. About 48 children will take part to see if the treatment is safe and what side …

This study tests whether combining two drugs, nivolumab and relatlimab, can help control melanoma that has spread to the brain. About 30 adults with active brain metastases will receive the combination and be monitored for side effects and tumor response. The goal is to improve d…

This study tests whether freezing only the part of the prostate that contains cancer (focal cryotherapy) can control intermediate-risk prostate cancer. About 30 men with a single area of cancer will receive this targeted treatment. The goal is to reduce side effects while keeping…

This study tests whether a combination of three drugs—pembrolizumab, bevacizumab, and low-dose cyclophosphamide—can help control high-grade ovarian cancer that remains after standard frontline therapy. About 20 women with minimal residual disease will receive the treatment to see…

This study tests a new drug called axatilimab, alone and with the standard drug ruxolitinib, for people with myelofibrosis (MF) or chronic myelomonocytic leukemia (CMML). The goal is to find a safe dose and see if the combination helps control the disease. About 66 adults who hav…

This study tests whether giving two powerful cell therapies together can control large B cell lymphoma that has returned or not responded to first treatment. About 40 adults will receive the drugs axicabtagene ciloleucel and glofitamab. The goal is to manage the disease, not to c…

This early-phase study tests whether fecal microbiota transplantation (FMT) can safely treat severe diarrhea or colon inflammation caused by immune-checkpoint inhibitor drugs in people with genitourinary and other cancers. About 40 participants will receive FMT to see if it reduc…

This study tests whether two drugs, niraparib and dostarlimab, can control advanced cancers that have spread to the brain. It includes 120 adults with specific cancer types like BRCA-mutated or lung cancers. The goal is to manage the disease, not cure it, and researchers will mon…

This study tests a new drug combination for men with an aggressive type of prostate cancer. The goal is to find the best dose of ADI-PEG20 when given with two standard chemotherapy drugs. About 30 men will take part to see if the combo is safe and tolerable.

This study tests a combination of three drugs (quizartinib, decitabine, and venetoclax) in people with acute myeloid leukemia or high-risk myelodysplastic syndrome that is new or has returned. The goal is to find the best dose and see how well the drugs work together to stop canc…

This study tests whether the drug asciminib can help control chronic myeloid leukemia (CML) in people who were recently diagnosed. About 50 adults will take the drug, and researchers will monitor side effects and how well the cancer responds. The goal is to manage the disease, no…

This study tests whether adding cediranib or AZD6738 to olaparib can overcome resistance in people with advanced or metastatic breast cancer who have a BRCA gene mutation. About 60 participants will receive one of the combination treatments. The goal is to see if these combos can…

This early-stage trial tests a new drug called NP-101 in 35 adults with advanced solid tumors that have not responded to standard treatments. The main goal is to check the drug's safety and find the right dose. Researchers will also look for signs that the drug is shrinking tumor…

This study tests a combination of two chemotherapy drugs (CPX-351) plus a targeted drug (quizartinib) in people with acute myeloid leukemia (AML) or high-risk myelodysplastic syndrome (MDS). The goal is to find the best dose and see if the combo helps control the cancer. About 52…

This study tests a new treatment using specially engineered natural killer (NK) cells from donated cord blood. The cells are designed to target a protein called CD5 found on certain blood cancer cells. About 64 people with relapsed or hard-to-treat blood cancers will receive thes…

This early-phase study tests a new mix of three drugs (cyclophosphamide, axatilimab, and retifanlimab) in people with metastatic triple negative breast cancer that has spread and is no longer responding to standard treatments. The main goal is to find the safest dose and check fo…

This study is for people with multiple myeloma that has come back or stopped responding to other treatments. The trial has two parts: first, finding the best dose of a drug called belumosudil mesylate, and second, testing that dose alone or with dexamethasone to see if it can con…

This study tests a powerful mix of chemotherapy drugs, including nelarabine, for people with untreated T-cell acute lymphoblastic leukemia or lymphoblastic lymphoma. About 160 participants will receive the treatment to see how well it controls the cancer and what side effects occ…

This study tests whether two drugs, tucatinib and T-DM1, can control HER2-positive solid tumors that have spread to the brain. About 30 adults with this condition will receive the combination treatment. The main goal is to see how safe and tolerable the drugs are, and whether the…

This study tests whether a time-limited combination of three drugs (pirtobrutinib, venetoclax, and obinutuzumab) is safe and effective for people with untreated chronic lymphocytic leukemia (CLL) or Richter transformation (RT). About 60 adults with good organ function and perform…

This study tests whether a special type of immune cell (ONC-PluReceptor NK cells) given with two antibody drugs (epcoritamab and tafasitamab) can control B-cell Non-Hodgkin lymphoma that has come back or not responded to prior treatments. About 30 adults aged 18-80 who have alrea…

This study tests a new drug, valemetostat, combined with two standard treatments (rituximab and lenalidomide) for people with follicular lymphoma that has returned or not responded to prior therapy. About 60 adults will take part to find the safest dose and see how well the combi…

This early-stage trial tests a drug called talazoparib combined with one of three other drugs (palbociclib, axitinib, or crizotinib) in people with advanced solid tumors that have spread. The goal is to find the safest dose and see if the combinations can help control the cancer.…

This study provides compassionate access to a special device that selects CD34+ stem cells for patients whose stem cell transplant did not work well. The goal is to improve blood cell recovery and reduce complications like graft-versus-host disease. Up to 200 participants will re…

This study tests a drug called zanzalintinib given before surgery for people with advanced thyroid cancer. The goal is to see if the drug helps shrink the tumor and makes surgery more effective. About 45 adults with certain types of thyroid cancer that have spread locally will ta…

This early-phase study tests a new drug called rezatapopt combined with azacitidine in 24 adults with acute myeloid leukemia or myelodysplastic syndrome that has a specific TP53Y220C mutation and has not responded to standard treatment. The main goal is to check safety and side e…

This study tests whether a personalized cell therapy called obecabtagene autoleucel (obe-cel) can help control high-risk B-cell acute lymphocytic leukemia (ALL) in adults who have already completed their first round of treatment. About 30 participants will receive obe-cel as a co…

This study tests whether giving two drugs (cemiplimab and cetuximab) before salvage surgery can help control recurrent oral cavity squamous cell carcinoma. About 17 adults whose cancer returned at least 3 months after initial treatment will receive the drug combination, then unde…

This study tests a more intense treatment for a fast-growing type of brain cancer called IDH wildtype glioma. It combines higher doses of radiation with the chemotherapy drug temozolomide to try to stop the tumor from growing longer. The trial will enroll 40 adults with this spec…

This study tests a handheld device called the MasSpec Pen to see if it can tell the difference between tumors, non-cancerous growths, and normal tissue during surgery. About 60 people with MPNST or neurofibroma will take part. The goal is to help surgeons remove all the tumor whi…

This study is testing a new type of MRI scan (without a probe in the rectum) to see if it can accurately find aggressive prostate cancers in men with intermediate or high-risk disease. About 258 men who are planning to have their prostate removed will get this MRI first. The goal…

This study tests whether a special camera and a fluorescent dye can help doctors see which mouth sores are precancerous or cancerous. About 275 adults with mouth lesions who are already scheduled for surgery will have their mouths imaged before the procedure. The goal is to devel…

This study compares synthetic mammography (a 2D image made from 3D data) to standard digital mammography for detecting breast cancer. Researchers will look at medical records from 750 women to see if the synthetic method works just as well while using less radiation. The goal is …

This study tests whether a special MRI technique called magnetic resonance elastography (MRE) can tell the difference between tissue damaged by radiation and tumor that has grown back in people with a type of brain cancer called glioma. About 80 adults who have already had chemot…

This study tests whether advanced scans (PET/MR, PET/CT, and whole-body MR) can find leukemia that has spread outside the bone marrow in people newly diagnosed with acute myeloid leukemia (AML). About 77 participants will receive these scans to see how well they detect hidden dis…

This study compares two types of breast imaging—molecular breast imaging (MBI) and magnetic resonance imaging (MRI)—to see how well each finds or rules out breast cancer in women at high risk. About 300 women will take part. The goal is to find out if MBI works as well as MRI, wh…

This study is testing whether contrast-enhanced mammography (CEM) can detect breast cancer more effectively than standard mammography in women with dense breast tissue. Researchers will enroll 1,000 women aged 30-75 with dense breasts who already get yearly mammograms. The goal i…

This study tests whether a new type of PET scan (18F-FAraG) can find esophageal tumors and predict how well a patient responds to chemoradiation. About 60 adults with untreated, locally advanced esophageal cancer will receive the scan before and during treatment. The goal is to i…

This study aims to see if combining the standard CA-125 blood test with other tumor markers can help detect ovarian cancer earlier in women who are at low risk. Researchers will track changes in these markers over time in 8,000 postmenopausal women aged 50-75 who have at least on…

This study is testing a new, easy-to-use HPV test that could be done at a doctor's office without special lab equipment. Researchers want to see if this new test works as well as the standard HPV test. About 600 people with a cervix, aged 21 or older, will take part. If successfu…

This study looks at whether CT scans can help doctors predict how well pancreatic cancer patients will respond to chemotherapy. About 259 adults with pancreatic or liver cancer will get CT scans before and during treatment. The goal is to see if changes in the tumor's blood flow …

This early-phase study tests a special MRI scan (HP-MR) that may help doctors tell the difference between harmless and dangerous pancreatic cysts. About 20 adults with pancreatic cysts who are already scheduled for surgery will receive this scan before their operation. The goal i…

This study is testing a new radioactive tracer called [18F]FTT to see if it can make PET/CT scans better at finding solid tumors, like ovarian, breast, and other cancers. About 300 adults with known or suspected tumors will get an injection of the tracer and then have a scan. The…

This early-phase study is testing whether a special PET scan (18F-FSPG) and a blood test for tumor DNA can help doctors better guide treatment for liver cancer. About 60 adults with hepatocellular carcinoma will receive standard Y90 radioembolization therapy. The goal is to see i…

This study aims to make cervical cancer screening more accessible by using self-collection and HR-HPV testing instead of traditional methods. Researchers will work with healthcare providers, patients, and community members to develop education and training materials. The study in…

This early-stage study tests a new imaging agent called 18F-4FN for PET scans to safely detect inflammation in the body. It involves 55 adults with cancer who are on immunotherapy or have suspected inflammation. The goal is to see if this agent can highlight areas of inflammation…

This study is testing whether a special type of MRI (DCE-MRI) can predict a serious side effect called osteoradionecrosis (bone death) in people receiving radiation for head and neck cancer. About 1,400 participants will have MRI scans before, during, and after radiation to see i…

This study tests a special type of mammogram called CESM, which uses a dye injected into a vein to make breast tissue and blood vessels clearer. The goal is to see if CESM is better than standard mammograms at finding the cause of nipple discharge and detecting breast cancer. Abo…

This study tests a new imaging device that may help doctors see tumor tissue before taking a needle biopsy. About 150 people with suspected or confirmed cancer will take part. The goal is to see if the device is safe and can make biopsies more precise.

This study tests a new imaging device called the Active Biopsy Guidance System to help doctors decide when and where to take tissue samples (biopsies) from mouth lesions. About 90 adults with suspicious mouth spots or a history of oral cancer will participate. The goal is to see …

This early-phase study tests a special imaging agent called hyperpolarized pyruvate to see if it can help doctors better diagnose glioma, a type of brain tumor. About 13 adults with brain tumors will receive the agent before an advanced MRI scan. The goal is to improve how tumors…

This study aims to find better ways to screen and diagnose cervical cancer in Mozambique. Researchers will test a rapid HPV test and a special imaging system in about 678 women aged 25-49 who have had abnormal screening results. The goal is to see if these new methods are as accu…

This study tests whether a special PET-CT scan using PYLARIFY (piflufolastat F18) can better detect cancer that has spread in people with pancreatic cancer, liver cancer, or breast cancer. About 36 adults will get the scan, and doctors will compare the results to standard methods…

This study is testing a mixed meal test to better diagnose a specific type of diabetes (type 3c) that occurs in people with pancreatic cancer or chronic pancreatitis. Researchers will enroll 775 adults aged 30 to 84 who have new-onset diabetes and one of these pancreatic conditio…

This study tests if repairing the lymphatic system during breast cancer surgery can prevent lymphedema, a painful arm swelling. Researchers will enroll 50 women with breast cancer who are scheduled for lymph node removal. The goal is to see if immediate reconstruction reduces the…

This study tests if a procedure called lymphovenous bypass, done before lymph node removal, can prevent lymphedema (arm swelling). It involves 252 adults with breast cancer or melanoma who are scheduled for lymph node surgery. The bypass reroutes lymph fluid away from the arm, ai…

This study looks at whether removing the fallopian tubes first and delaying the removal of the ovaries is as safe as removing both at once for preventing ovarian cancer. It involves 100 premenopausal women with BRCA or other high-risk gene mutations. The goal is to see if the two…

This study tracks how nerve pain from chemotherapy develops in breast cancer patients. It also tests a brain-stimulating device called a closed-loop brain-computer interface to see if it can prevent that pain. About 45 participants will be observed or receive the experimental sti…

This study tests whether a special 'short stitch' closing method can prevent incisional hernias better than the usual method in 140 adults having open liver surgery for cancer. Participants are randomly assigned to one of two suture techniques. The main goal is to see which metho…

This study tests whether the drug canakinumab can prevent lung cancer in 50 people who have suspicious lung nodules that haven't gone away. Participants receive the drug and are monitored for nodule shrinkage and cancer development. The goal is to see if this approach can stop lu…

This study tests whether naproxen or aspirin can increase immune cells in the colon to help prevent cancer in people with Lynch syndrome, a genetic condition that raises cancer risk. About 40 adults will take one of these drugs or a placebo for a short time. Researchers will chec…

This study is creating an educational tool to help women and their doctors talk about using a levonorgestrel-releasing IUD to prevent endometrial cancer. The tool will be tested with 270 women, including those at risk and those who have had the cancer. The goal is to make it easi…

This study tests whether a lymphovenous bypass performed at the same time as groin lymph node removal can prevent lymphedema (chronic swelling). Twenty adults undergoing inguinal lymphadenectomy will receive the bypass, and researchers will monitor for side effects and swelling. …

This study tests a community-based approach to make cervical cancer screening easier for women who haven't had a Pap test in over 3.5 years. It involves 920 women in low-resource areas of Texas. The goal is to see if this strategy is safe and works well.

This study looks at two ways to treat fluid buildup in the lungs from cancer: using a small tube (catheter) alone or adding an antibiotic (doxycycline) to help seal the lung. The goal is to see if adding the antibiotic lets patients have the tube removed sooner. About 208 adults …

This study aims to develop and test a yoga program that is adapted to different cultures for cancer patients who are in the hospital for a stem cell transplant. About 60 adults from India, Tanzania, and the United States will take part. The main goal is to see if the program help…

This study tests whether listening to live or recorded music before neurosurgery can lower stress, improve mood, and reduce pain. Researchers will measure changes in vital signs, stress hormones, and how patients feel using questionnaires. The goal is to find a simple, drug-free …

This study tests whether using a more advanced imaging method (MR-LINAC) during spinal radiation therapy leads to better treatment results and improved quality of life. About 40 adults with cancer that has spread to the spine will receive stereotactic radiosurgery while being sca…

This study tests whether a reward-based exercise program called TEAM Me can help children and young adults with cancer stay active during a stem cell transplant. Participants earn tokens for walking and other activities, which they can trade for prizes. The goal is to see if the …

This study tests whether alteplase, a drug that dissolves blood clots, can improve drainage of fluid around the lungs and reduce shortness of breath in people with cancer. About 30 participants with a non-draining pleural effusion will receive either alteplase or a placebo throug…

This study looks at whether using a longer IV catheter, placed with ultrasound guidance, can reduce the chance of failure in cancer patients who need IV access in the emergency department. About 400 adults with difficult veins who are expected to stay in the hospital for more tha…

This study tests a new spiritual care program called PEACE for people with advanced cancer. It involves chaplains and doctors working together to help patients explore how their faith affects their medical choices. The goal is to see if this approach is practical and helpful for …

This early-phase study tests whether a weight-loss drug called tirzepatide can safely help overweight or obese men with intermediate-risk prostate cancer lose weight before their prostate removal surgery. About 30 participants will take the drug and be monitored for side effects.…

This study looks at whether giving cancer survivors free healthy food and online cooking lessons can help them feel better and stay healthy. About 80 people who have finished cancer treatment in the last 5 years and struggle to afford food will take part. The program aims to ease…

This study tests a mobile app that guides lung cancer patients and their family caregivers through yoga exercises at home. The goal is to see if the app is safe, easy to use, and helpful during radiation treatment. About 60 patient-caregiver pairs will participate.

This study explores whether a virtual, group-based expressive writing program can improve quality of life for survivors of adolescent and young adult cancer. Researchers will enroll 30 survivors aged 18-39 who were diagnosed between 1 and 5 years ago. Participants will complete f…

This study tests whether a virtual group therapy program, called Meaning-Centered Psychotherapy, can help people with cancer feel better emotionally. Researchers want to see if talking about meaning and purpose in a group setting reduces distress and improves quality of life. The…

This study looks at two different supportive care programs designed to improve the emotional wellbeing and quality of life for people with advanced (stage IV) cancer and their family caregivers. About 400 patient-caregiver pairs will take part. The goal is to see which program be…

This study looks at whether giving only radiation after lumpectomy is safe and effective for women aged 60 and older with early-stage, low-risk breast cancer. The goal is to see if skipping hormone therapy can improve quality of life while still controlling the cancer. About 300 …

This study tests whether adding cryoablation (freezing cancer cells) to standard radiation therapy provides better pain relief for people with cancer that has spread to their bones. About 40 adults with advanced cancers like prostate, kidney, or melanoma will be enrolled. The goa…

This study tests whether a special yoga program can improve physical function, fatigue, sleep, and quality of life for people with lung or esophageal cancer who are getting radiation therapy, as well as for their family caregivers. About 400 patient-caregiver pairs will take part…

This study tests whether adding bright light therapy, methylphenidate, or melatonin to cognitive behavior therapy (CBT) can improve sleep, fatigue, anxiety, and depression in 188 adults with advanced cancer. Participants will receive CBT plus one of the add-on treatments or a pla…

This study is testing a new treatment called nanosecond pulsed field ablation (nsPFA) for people with benign (non-cancerous) thyroid nodules. The procedure uses short electrical pulses to shrink the nodule and improve symptoms. Researchers will follow 30 participants aged 18 to 8…

This study looks at whether a digital art activity can help cancer patients better express their distress, symptoms, and experiences. Researchers will enroll 60 adult cancer patients who are currently receiving treatment. Participants will use a digital tablet to create art and t…

This study looks at whether expressive writing can help cancer survivors cope with stress, especially during tough times like the COVID-19 pandemic. About 414 adults who were diagnosed with cancer in the past 3 years will participate online from home. They will write about their …

This study tests a tele-exercise program called RISE-YA to see if it can reduce cancer-related fatigue in young adults (ages 18-39) who are brain tumor survivors. Participants must be 6 months to 5 years past treatment and currently get little exercise. The goal is to improve ene…

This study tests whether the drug ustekinumab can control diarrhea and colon inflammation caused by immune checkpoint inhibitors in cancer patients. About 10 adults with solid tumors who have moderate to severe symptoms will receive ustekinumab. The goal is to ease these side eff…

This early-phase study tests whether a non-invasive brain stimulation technique called rTMS can help people with impulse control disorders, specifically excessive eating. Researchers will enroll 30 adults aged 21 to 60 with a BMI over 30 to receive personalized, accelerated rTMS …

This study looks at whether using a mask that pushes air into the lungs (non-invasive ventilation) can help cancer patients who have trouble breathing and low oxygen levels. The goal is to see if this method reduces the need for a breathing tube compared to standard oxygen therap…

This study looks at whether a special vacuum dressing (negative pressure wound therapy) can help heal the belly incision better than standard bandages in obese women having breast reconstruction surgery. About 80 participants will be randomly assigned to receive either the vacuum…

This early-phase study tests whether a cream made from capsaicin (the compound that makes chili peppers hot) can reduce nerve pain in the feet and legs caused by chemotherapy. About 20 adults who finished chemo within the last year and have had pain for over 3 months will apply t…

This study looks at whether a couple-based meditation program can improve physical, emotional, and spiritual well-being for people with stage IV lung cancer and their romantic partners. About 300 couples will take part. The goal is to see if the program is practical and helps bot…

This study looks at two surgical techniques, TMR and RPNI, used alone or together to reduce long-term pain in the remaining limb and phantom limb pain in cancer patients who have had an amputation. About 45 adults will be randomly assigned to one of three groups to see which appr…

This study tests whether a custom-made video, showing symptoms and side effects based on each patient's own brain scan, can lower anxiety for people with brain tumors and their caregivers during radiation treatment. About 117 patients with newly diagnosed glioma and their caregiv…

This study tests a parenting support program for 120 parents with advanced cancer and their spouses. The program aims to reduce parenting worries, improve family communication about cancer, and boost emotional wellbeing. Participants must have a child aged 4-16 living at home and…

This study follows 50 adults who choose radiofrequency ablation (RFA) instead of surgery for benign thyroid nodules or low-risk papillary thyroid cancer. RFA uses heat from a tiny needle to shrink the nodule or tumor. Researchers track how well the treatment works over time and h…

This study tests whether a drug called methylnaltrexone is safe for people with head and neck cancer when taken for two weeks before their surgery. The drug is already used for constipation, but researchers want to see if it can be given safely in this setting. About 25 adults wi…

This study looks at whether a simple exercise program is practical and helpful for people with non-small cell lung cancer who are getting radiation therapy, along with their family caregivers. About 40 pairs (patient and caregiver) will take part. The goal is to see if exercising…

This study tests whether psilocybin (the active ingredient in magic mushrooms) combined with talk therapy can safely help cancer survivors with depression and anxiety. Twenty adults who have finished cancer treatment and have no brain tumors will receive the therapy. The main goa…

This study tests a web-based program called Project Prepare for people with throat cancer who are getting radiation therapy. The program aims to help patients stick with swallowing exercises and coping strategies to reduce long-term side effects. About 300 participants will use t…

This study tests whether domperidone can help control symptoms like pain, bloating, nausea, and vomiting in people with chronic digestive disorders. It is for adults who have not gotten relief from standard treatments. The main goal is to see if symptoms improve over 8 weeks usin…

This early-phase study is testing whether a minimally-invasive procedure using special light-activated nails can help people with cancer that has spread to the pelvic bone. The goal is to see if patients have better function and less pain three months after the procedure. About 5…

This study tests whether olanzapine, a medication typically used for mental health conditions, can help lower opioid cravings and misuse in adults with cancer who are on long-term opioid therapy for pain. About 87 participants will receive either olanzapine or a placebo to see if…

This study looks at whether having fewer follow-up scans after surgery for soft tissue sarcoma can lower patients' fear of the cancer coming back. About 227 adults who finished treatment will be split into two groups: one with limited follow-up and one with intense follow-up. Res…

This study tests whether a custom 3D-printed mouth guard (oral stent) can reduce mouth blisters and sores in people receiving radiation for head and neck cancer. About 119 adults will be randomly assigned to get radiation with or without the stent. The goal is to see if the stent…

This study tests whether a nurse-delivered hypnosis session before and during breast cancer surgery can lower the amount of opioid painkillers patients need afterward. About 225 adults having a unilateral breast procedure will be randomly assigned to hypnosis alone, hypnosis plus…

This study tests a short program designed to improve the emotional wellbeing and quality of life of people caring for a loved one with advanced cancer. Researchers will enroll 150 adult caregivers who live with a patient with stage IV cancer. Participants will learn skills to inc…

This study looks at whether writing about their experiences can improve the health of Asian American breast cancer survivors. About 192 people who finished cancer treatment in the last 5 years will take part. They will write and report how they feel, and researchers will track an…

This study looks at whether a computer-assisted vacuum procedure to remove blood clots from the lungs is safe and improves quality of life for cancer patients with a moderate-risk pulmonary embolism. About 25 adults with cancer and a confirmed clot in a major lung artery will tak…

This study tests a special yoga program for women with advanced ovarian cancer who will receive chemotherapy before surgery. The program aims to improve quality of life and overall well-being. Researchers want to see if it is practical and helpful for patients.

This study tests a program called ApricityCare that helps doctors find and treat side effects from cancer therapy early. The goal is to see if catching problems sooner can keep patients on their treatment longer. About 425 adults with cancer will take part.

This study tests whether a shorter course of high-precision radiation (SBRT) can safely reduce symptoms in people with head and neck cancer that cannot be cured. About 108 adults whose cancer has returned or spread will receive either standard or shorter radiation. The goal is to…

This study tests a newer, more precise radiation therapy (SBRT) against standard radiation to see which better relieves pain from cancer that has spread to the bones. About 220 adults with solid tumors or multiple myeloma and pain at the treatment site will take part. The goal is…

This study aims to improve breast reconstruction after mastectomy by using custom 3D-printed molds to shape tissue into a natural breast form. Researchers will enroll 160 adults scheduled for flap-based reconstruction. The goal is to make surgery more efficient and reduce complic…

This study tests a short counseling program called Focused ACT (FACT) to help people with advanced cancer feel less anxious about death. About 70 adults whose cancer has not responded to at least one treatment will take part. The program helps patients talk about important life a…

This study looks at whether having a conversation about care goals in the emergency room can improve quality of life for people with advanced lung or gastrointestinal cancer. It involves 200 adults who have symptoms like trouble breathing or confusion. The goal is to better suppo…

This study tests whether a CPAP device (a mask that gently blows air into the lungs) can reduce tumor movement during radiation therapy for lung cancer. About 30 people will be enrolled to compare CPAP with a standard breath-holding technique. The goal is to see if CPAP helps kee…

This study compares symptoms, especially appetite, in patients who have one of two types of minimally invasive stomach cancer surgery: removing only the upper part of the stomach or the whole stomach. Researchers will track how patients feel using a simple questionnaire. The goal…

This study tests whether psilocybin (the active ingredient in magic mushrooms) combined with talk therapy can safely reduce depression and anxiety in 30 adults with advanced cancer who are on long-term treatment. Participants will receive the drug in a controlled setting and be m…

This study tests whether combining a nerve pain medication (duloxetine) with neurofeedback brain training can better reduce chemotherapy-related nerve pain than either treatment alone. About 380 adults with nerve damage from cancer treatment will participate. The goal is to impro…

This study aims to see if a course called BBCSI, led by trained peers from the community, can improve the quality of life for Black breast cancer survivors. About 46 Black women who had early-stage breast cancer will take the course. Researchers will track safety and any side eff…

This study looks at whether people who have part of their thyroid removed can safely go home the same day instead of staying overnight in the hospital. Researchers will track side effects, patient preferences, and costs. About 224 adults having this surgery will take part.

This study tests whether an accelerated recovery program can safely shorten hospital stays for 36 adults undergoing minimally invasive liver surgery. Participants must have a tumor suitable for a specific type of liver resection, no cirrhosis, and live within 50 miles of the medi…

This study is testing whether a higher dose of radiation can be safely given to cancer patients whose tumors press on the spinal cord. The approach, called CDE-SSRS, aims to better control the tumor while protecting the spinal cord. About 60 adults with spinal metastases will be …

This study looks at whether a supervised exercise program can help people with early-stage triple negative breast cancer who are receiving immunotherapy before surgery. About 33 participants will take part in aerobic exercise sessions. The goal is to see if the program is practic…

This early-phase study is testing the safety of two devices (NovoTTF-200M and 200A) for people with spinal tumors that have not responded to surgery or radiation. About 30 participants will receive the treatment alone or with standard care. The goal is to see if the devices are s…

This study looks at whether nerve transfer surgery can improve facial movement and quality of life for cancer patients who have facial paralysis after treatment. About 40 adults who are scheduled for this surgery will take part. Researchers will track side effects and measure cha…

This study tests if a nerve stimulation treatment, alone or with a steroid shot, works better than a standard steroid shot for long-term knee pain. About 45 adults with chronic knee pain will be enrolled. The goal is to see which approach improves knee movement and reduces pain m…

This study tests whether a small device that sends mild electrical pulses to nerves in the leg can reduce pain caused by chemotherapy. Ten adults who have had chemotherapy in the past year and still have nerve pain will try the treatment. The goal is to see if it is safe and if i…

This study tests a physical activity program designed for cancer survivors and their caregivers. About 164 adults who have finished cancer treatment (except hormone therapy or maintenance chemo) will take part. The goal is to see if the program improves physical function and redu…

This study tests whether combining counseling and education with a placebo pill can better ease severe fatigue in people with advanced cancer, compared to either approach alone. About 240 adults with metastatic cancer and fatigue lasting at least 2 weeks will participate. The goa…

This study tests four treatments (haloperidol, chlorpromazine, valproic acid, and a placebo) alongside standard non-drug care to calm agitated delirium in hospitalized adults with advanced cancer. The goal is to find which option best reduces distress and suffering. About 42 part…

This study tests a personalized treatment plan called SPOT-ON that combines oxygen therapy with other supportive care to reduce shortness of breath in cancer patients. The trial will enroll 150 adults hospitalized with cancer who have significant breathing difficulty. The goal is…

This early-stage study tests whether a precise radiation dose to the pituitary gland (hypophysectomy) can safely reduce severe cancer pain that hasn't responded to standard treatments like opioids. About 40 adults with advanced cancer and hard-to-control pain will receive this on…

This study is creating and testing educational materials about medullary thyroid cancer that are easy to understand and culturally appropriate for Spanish-speaking Hispanic or Latino patients. Researchers will ask 40 participants to fill out surveys to see if the new materials he…

This study looks at what breast cancer survivors and their family members know about chemicals in personal care products that might affect hormones. Researchers also want to see if there is a link between being overweight and these chemicals. The study involves filling out questi…

This study looks at how well healthcare providers and family caregivers agree on the level of discomfort in advanced cancer patients who have hypoactive delirium (a state of reduced awareness and responsiveness). Researchers will survey both groups to compare their perceptions. T…

This study aims to see if a special type of MRI scan can measure and predict damage to the jaw and mouth bones caused by radiation therapy for head and neck cancer. Researchers will follow 300 adults receiving radiation to track how this damage develops over time. The goal is to …

This study aims to understand why some people respond better to a brain stimulation treatment (rTMS) for smoking. Researchers will measure brain activity in 100 smokers aged 21-60 to see if emotional triggers affect treatment success. The goal is to personalize future therapies f…

This study aims to learn about the symptoms and changes patients experience while receiving treatment for sinonasal or nasopharyngeal cancer. Researchers will use a questionnaire to track how severe symptoms are over time. The goal is to better understand what patients go through…

This study looks at how a person's ancestry and financial situation influence their choice of bone marrow donor cells and whether they receive a genetically matched transplant. Researchers will follow 1,200 adults who are candidates for allogeneic transplantation. The goal is to …

This study looks at how the COVID-19 pandemic impacted the well-being and quality of life of people with melanoma. Researchers are surveying over 1,100 participants about their experiences, stress, and social or financial disruptions. The goal is to understand what helped some pe…

This study looks at a rare cervical cancer called clear cell carcinoma. Researchers will test tumor samples from 70 patients to learn more about its genetic and protein features. The goal is to better understand this disease, not to test a new treatment.

This study aims to create and test an educational tool that teaches people how to prevent liver cancer. About 40 adults who have not been diagnosed with liver cancer will review the materials and share their thoughts. The goal is to make sure the information is clear, helpful, an…

This study tests tumor tissue from up to 12,000 cancer patients to find gene changes (mutations). The goal is to match each patient with a clinical trial or therapy that targets their specific cancer type. Researchers will also build a database of mutations to help future patient…

This study looks at how what you eat and the bacteria in your gut might affect your chances of developing colorectal cancer. Researchers will collect tissue, stool, and blood samples from 30 people undergoing screening colonoscopies. The goal is to understand the link between die…

This study gathers medical information and tumor samples from 2,000 people with low-grade ovarian or peritoneal tumors. The goal is to create a detailed database that helps researchers understand these rare cancers better and develop improved treatments in the future. Participant…

This study aims to identify women at risk for hereditary breast, ovarian, and colorectal cancers by offering genetic screening and counseling through mobile mammography units. About 1,000 underserved women in Texas who come for their routine mammograms will be invited to particip…

This study collects blood, stool, and saliva samples from 150 people with non-small cell lung cancer who are getting chemotherapy, radiation, and immunotherapy. The goal is to find early signs of lung inflammation (pneumonitis), a common side effect. Researchers hope this will he…

This study tests whether a screening tool can improve how well patients with advanced lung cancer understand their illness. About 100 adults recently diagnosed with stage IV lung cancer will either use the tool or receive usual care. The goal is to help patients make informed dec…

This study reviews medical records from 600 lung cancer patients who had surgery between 2004 and 2019. The goal is to see if the use of robotic surgery has led to more atypical segmentectomies (removing part of a lung lobe). Researchers want to understand how robotic methods com…

This study creates a registry of medical information and biological samples (blood, tissue, stool) from people with inflammatory or invasive breast cancer. The goal is to collect data for future research that may lead to better ways to treat and understand inflammatory breast can…

This study tests a new way to map important brain areas during tumor surgery. Doctors will use a special grid to record brain activity while patients move or speak. The goal is to see if this method helps protect functions like movement and speech better than current techniques. …

This study is for people with RUNX1 familial platelet disorder, a rare inherited condition that raises the risk of bleeding and leukemia. Researchers want to see if it's safe to collect the person's own blood stem cells using a standard process. Only 4 participants will take part…

This study looks at how people with certain early blood conditions (MGUS and smoldering myeloma) feel day-to-day. About 400 adults will fill out short questionnaires about their symptoms and concerns. The goal is to help doctors better understand what matters most to patients.

This study asks brain cancer patients about their experience with telemedicine compared to in-person visits. Researchers want to learn if patients feel they receive good care through virtual appointments. The goal is to improve how care is delivered to people with brain tumors.

This study looks at how the bacteria in your gut might cause stomach issues like diarrhea and colitis when you take certain cancer drugs called immune checkpoint inhibitors. Researchers will collect stool, blood, and tissue samples from 800 people with melanoma, lung cancer, or g…

This study follows 260 cancer patients who are on long-term blood-thinner medication for blood clots (VTE). Researchers will track how well patients take their medicine, their quality of life, and healthcare costs. The goal is to learn about patient experiences, not to test a new…

This study tests whether a simpler food tracking app called MySnackTracker works as well as the usual method of recording everything you eat. Researchers will compare how satisfied people are and how well they stick with each method. About 90 adults who already take part in certa…

This study tests advanced imaging methods to tell the difference between true tumor growth and pseudoprogression (a harmless scan change after treatment) in people with brain cancer. About 25 adults who have had brain tumor treatment and show a new suspicious finding on scans wil…

This study is for adults about to start immune checkpoint inhibitor therapy for cancer. Researchers want to understand why some patients develop heart problems from this treatment. They will analyze blood samples and genetic factors from 1200 participants to find clues that could…

This study looks at how radiation treatment for esophageal cancer affects the body's ability to respond to the pneumonia vaccine. Researchers will measure antibody levels in 80 patients before and after vaccination. The goal is to understand if radiation-induced low white blood c…

This study looks at whether regular MRI scans after radiation therapy can help predict damage to healthy tissue in patients with mouth or skull base cancers. Researchers will track changes in MRI images over time to see if they can spot early signs of a condition called osteoradi…

This study gathers information on side effects from proton therapy in 5,000 adults with various cancers. Researchers will collect details on treatment plans and any short- or long-term side effects. The goal is to better predict who might have side effects and improve future care…

This study aims to see if using advanced MRI helps doctors target brain tumor biopsies more accurately than standard methods. About 50 adults with suspected brain tumors will get an extra MRI scan before their planned surgery. Researchers will compare the biopsy results from adva…

This study looks at how much of the radioactive drug Pluvicto reaches tumors and organs in patients whose kidneys or bone marrow are not working well. About 25 people will be enrolled to check for side effects and safety. The goal is to better understand dosing in these patients,…

This study aims to create personalized computer walking models for people with pelvic sarcoma, a rare bone cancer. The models will help doctors plan the best surgery and rehabilitation to maximize each patient's ability to walk after treatment. The study involves 130 adults who h…

This study builds a database of 1000 breast cancer survivors aged 50 or younger who have dense breast tissue. Researchers will track their MRI scans over time to see if MRI helps find new cancers that mammograms might miss. No new treatments are tested; the goal is to gather info…

This study aims to understand why people with hereditary colorectal cancer syndromes have different symptoms and outcomes. Researchers will compare patients and their family members to see how genes affect the disease. The goal is to learn more, not to test a new treatment.

This study looks at occupational stress in surgeons and musicians by using wearable brain monitors, saliva tests, and questionnaires. Researchers want to understand how these demanding jobs affect the body and mind. The study involves 20 adults and is run by MD Anderson Cancer Ce…

This study tracks memory and thinking changes in 100 adults with blood cancers who receive whole brain radiation. Researchers will test cognitive skills like recall and attention over time. The goal is to better understand the mental side effects of this treatment, not to change …

This study is testing a new imaging agent called 18F-4FN for PET/CT scans in 16 adults with chronic graft-versus-host disease (GVHD) affecting their joints. The goal is to see if the scan is safe and can help doctors see disease activity better. Participants must be at least 18 a…

This study is creating a large collection of mammogram images, blood samples, and health information from 10,000 women getting routine screening mammograms. The goal is to build a resource for future research on breast cancer and women's health. Participants provide a blood sampl…

This study collects extra tissue and fluid from routine lung procedures that would otherwise be thrown away. Researchers will use these samples to better understand lung complications in cancer patients. Up to 12,000 adults undergoing pulmonary procedures at the Cardiopulmonary C…

This study is testing whether wearing a fitness tracker (like a Fitbit) can give doctors a better picture of how active cancer patients are, and whether that activity level relates to how well they are doing overall. About 590 people with various cancers will wear activity monito…

This study looks at how radiation therapy changes immune cells inside breast cancer tumors. Researchers want to see if radiation helps immune cells enter the tumor and fight cancer cells. About 36 adults with invasive breast cancer will have tumor samples taken before and after r…

This study follows 200 people who had hemipelvectomy surgery (removal of part or all of the pelvis) for pelvic tumors. Researchers want to learn how these patients function and feel in daily life after different types of surgery. The goal is to find ways to improve recovery and q…

This study looks at whether having extra MRI scans during radiation and chemotherapy can help doctors see changes in high-grade glioma (a type of brain cancer) early. By spotting these changes, doctors may be able to adjust the treatment plan to better target the tumor. About 80 …

This study follows people who have already received gene transfer therapy for cancer or other conditions. The goal is to monitor long-term safety and any side effects over up to 15 years. No new treatment is given; participants provide health updates and occasional blood samples.…

This study is testing a new questionnaire system to see how well it measures common cancer symptoms and how those symptoms affect quality of life. Researchers will ask about 6,500 cancer patients, caregivers, and doctors to fill out surveys. The goal is to create a better way to …

This study looks at how the way medical information is presented affects the treatment choices of people with advanced cancer. Researchers will enroll 400 adults with advanced solid tumors or aggressive lymphoma who have already tried at least two cancer treatments. Participants …

This early-stage trial is testing whether the drug ulixertinib can cross the blood-brain barrier in people with recurrent brain tumors called gliomas. About 40 adults will take the drug before surgery to see how much reaches the tumor and how safe it is. The goal is to learn if t…

This study looks at whether a remote training program called Project ECHO can improve the quality of palliative care for advanced cancer patients and their caregivers in underserved areas of Kenya, Nigeria, Ghana, South Africa, India, and Ethiopia. About 312 patients and their ca…

This study talks to adults who have finished a weight loss program to learn what they like and dislike about using a mobile app to track food and drinks. The goal is to help doctors and app designers make better tools that people find useful and appealing. About 39 participants w…

This study is for 1000 people with oral cancer or precancerous mouth lesions. Researchers will collect tissue samples and ask participants about their symptoms before, during, and after treatment. The goal is to find better ways to predict how the disease will behave and which tr…

This study looks at the best ways to teach heavy smokers about lung cancer screening using tobacco quitlines. Researchers will work with 800 participants, including quitline staff and smokers aged 55-80 with a heavy smoking history. The goal is to see what methods work best to sh…

This study is collecting information from over 2000 people with advanced medullary thyroid cancer to understand how the disease develops and changes over time. Researchers will use a patient registry to look at medical records, genetics, and patient-reported experiences. The goal…

This study tests whether a new type of MRI scan, using an inhaled gas called hyperpolarized xenon-129, can help doctors identify and predict lung damage caused by radiation therapy in lung cancer patients. The study will include 70 participants: healthy volunteers and lung cancer…

This study looks at how cancer patients who also have heart failure feel day-to-day. Researchers will ask 100 participants about their symptoms and quality of life using simple questionnaires. The goal is to better understand the challenges these patients face, not to test a new …

This study aims to help heavy smokers aged 55 to 80 make informed decisions about lung cancer screening. Researchers are updating a decision aid and testing it with 620 participants. The goal is to improve understanding and support better choices, not to treat or prevent disease.

This study aims to create a shared decision-making tool for Spanish-speaking women with advanced ovarian cancer. The tool will help them and their doctors discuss and choose maintenance therapy after chemotherapy. About 70 patients will test the tool to see if it reduces regret a…

This study looks at why people with Li-Fraumeni syndrome (a condition that raises cancer risk) might agree to join a future trial comparing standard genetic counseling with a personalized version. About 500 participants will answer questions about their willingness to take part. …

This study looks at how lifestyle factors like diet, exercise, mental health, and social support affect quality of life and health outcomes in people with melanoma. Researchers will survey up to 5,000 participants to understand these connections. The goal is to use this informati…

This study uses a special type of MRI (called hyperpolarized 129-Xenon MRI) to look at lung function in adults who have had a bone marrow transplant and developed lung problems. Researchers want to see if this scan can measure how well the lungs are working and predict if the con…

This study is testing whether giving nutrition through a feeding tube after a stem cell transplant is safe and practical. It involves 40 children and young adults aged 2 to 25. The goal is to see if this method works better than standard care.

This study looks at whether changes in pupil size and reactivity can help predict neurological side effects in people receiving CAR-T cell therapy for certain lymphomas. Researchers will monitor 100 adults at MD Anderson Cancer Center before and after treatment. The goal is to fi…

This study is creating a database of information from 750 people with a rare type of cervical cancer called neuroendocrine carcinoma. Researchers will look at medical records to understand how the disease behaves, what treatments patients receive, and what happens to them over ti…

This study aims to understand how rheumatic side effects (like arthritis) from cancer immunotherapy affect patients' daily lives. Researchers will interview 20 adults who have experienced these side effects to learn about their severity and impact. The goal is to improve future c…

This study is testing a decision aid to help people decide whether to get screened for lung cancer. The tool is designed for patients in a safety-net healthcare system. Researchers will enroll 360 current or former smokers aged 50-80 to see if the aid is safe and helpful.

This study gathers blood, saliva, urine, and stool from up to 1,600 children with recurrent or chronic pancreatitis. Researchers look for genetic markers that might increase the risk of pancreatic cancer later in life. No treatment is given—the goal is simply to learn more about …

This study gathers information from 100 adults with blood cancers who receive CAR-T therapy and/or radiation as part of their standard care. The goal is to learn how these treatments work together, including side effects and how long the benefits last. By collecting this data, do…

This study looks at whether a tool called DIGEST helps doctors better measure swallowing problems in cancer patients. Researchers will work with 85 hospitals and clinics to see if they start using this tool regularly. The goal is to improve how swallowing issues are tracked and t…

This study tests whether a special type of MRI, called hyperpolarized MRI, can predict how well thyroid and head/neck cancers respond to radiation or drug therapy before surgery. About 42 participants will get this imaging before and after one week of treatment. The goal is to se…

This study talks to women with and without endometrial cancer to learn what they know about risk factors and prevention options. Researchers hope to create a tool that helps women make informed decisions. About 45 women will take part at MD Anderson Cancer Center.

This study looks at a method called 'Teaching the Teachers' to see if it helps spread liver cancer diagnosis guidelines more effectively. Researchers will teach the guidelines to expert radiologists, who then teach other doctors. The goal is to see if this approach increases how …

This study explores whether magnetic resonance spectroscopy (MRS) can be used to safely evaluate spinal cord lesions. Researchers will test the technique in healthy volunteers and patients with leptomeningeal disease who are receiving radiation. The main goal is to see if MRS is …

This study looks at how chemoradiation for locally advanced lung cancer affects the heart. Researchers will track heart injury and fitness in 100 patients receiving treatment tailored to their individual risk. The goal is to learn if personalized planning can reduce heart problem…

This study is testing a new screening tool called SOCS-OTS to see if it can correctly identify cancer survivors who need occupational therapy services. Researchers will compare the tool's results with a standard screening measure already used in the rehab clinic. About 80 adults …

This study follows 100 men with low- or very low-risk prostate cancer who choose active surveillance (monitoring instead of immediate treatment). Researchers will use remote symptom tracking and tissue samples to see how the disease progresses over 5 years. The goal is to learn w…

This study tests a rice-sized device that is temporarily placed inside a sarcoma tumor. The device releases tiny amounts of up to 10 different drugs to see which ones damage the tumor tissue. The goal is to find the most effective drug for each patient without exposing the whole …

This study aims to understand the challenges patients with advanced thyroid cancer face in getting treatments and how well they tolerate and respond to available medications in everyday settings. Researchers will collect data from 459 adults with anaplastic or poorly differentiat…

This study looks at whether a blood test that finds tiny bits of tumor DNA (called cfDNA) can help doctors see if lymphoma is still present after treatment. About 517 adults with diffuse large B-cell lymphoma will give blood samples before and after therapy. The goal is to see if…

This study follows 430 people with stage I-IV rectal cancer to see how surgery affects their daily life and well-being. Participants fill out questionnaires about their health and preferences. The goal is to learn more about what life is like after treatment, not to test a new dr…

This study is creating a database of medical information from up to 2000 people with mesonephric-like adenocarcinoma (MLA), the rarest form of uterine cancer. Researchers aim to learn more about the disease's characteristics and behavior. Participants must be over 18 and have a c…

This study surveys up to 9 radiology residents to see how comfortable they feel performing simulated blood vessel procedures after training on a special simulator. The goal is to improve hands-on training in a safe environment, which may lead to safer patient care in the future. …

This study looks at whether regularly checking a heart injury marker (troponin) in cancer patients receiving immune checkpoint inhibitors can lower the risk of heart-related problems. About 980 adults will take part. The goal is to see if this monitoring helps catch and prevent h…

This study explores how cancer treatments cause nerve pain by using simple sensory tests (like heat, cold, and touch) and small skin samples. Researchers aim to better understand why this pain happens and how to measure it. The study involves 450 adults with advanced cancer who h…

This study looks at how much lung cancer patients walk and sleep after surgery, using a Fitbit to track activity. Researchers want to see if more walking leads to fewer complications and better recovery. About 240 adults having lung surgery will participate. The goal is to learn …

This study is testing whether a simple blood test can find tiny bits of tumor DNA left after treatment, which might help doctors know if colorectal cancer will return. Researchers will collect blood samples from 1,000 people with colorectal cancer who have finished their main tre…

This study is creating and testing a decision aid for people with medullary thyroid cancer and their caregivers. The tool helps patients and doctors decide together whether to start or stop drugs, join clinical trials, or continue active monitoring. The goal is to help patients m…

This study looks at how the COVID-19 pandemic impacted the mental health of 20,000 employees at MD Anderson Cancer Center. Researchers are using surveys to measure stress and emotional well-being during and after the pandemic. The goal is to understand what factors put workers at…

This study is for adults with certain advanced solid tumors (non-small cell lung cancer, colorectal cancer, or ovarian cancer). Researchers want to find biological markers that show how the experimental drug SAR444881 works, alone or with cemiplimab. About 40 participants will re…

This study looks at tissue samples from parathyroid tumors to help doctors tell different tumor types apart more accurately. By understanding the molecular and genetic features of these tumors, researchers hope to reduce misdiagnosis, unnecessary surgeries, and patient stress. Th…

This study looks at the financial stress people face after surgery for bone or soft tissue sarcoma. Researchers want to understand how the cost of cancer care affects patients' quality of life. About 100 adults who can read and write English will fill out questionnaires before an…

This study aims to understand what helps or hinders a positive experience for Asian patients being treated for cancer at MD Anderson. Researchers will survey former patients and healthcare providers to identify key factors. The goal is to use these insights to improve care and su…

This study looks at how a dedicated care program (YOLC) affects satisfaction and needs of people under 50 with lung cancer. About 75 participants will fill out surveys over a year. The goal is to learn what support helps most, not to test a new treatment.

This study follows 200 people with early blood conditions (MGUS or smoldering myeloma) that sometimes turn into multiple myeloma. Researchers will track age, blood protein levels, bone marrow cells, genes, and bone health to find patterns that predict progression. No treatments a…

This study looks at what causes biliary tree cancers by examining environmental, viral, and genetic factors. Researchers will study 1,500 people, including patients and healthy volunteers, to find markers that predict cancer development and treatment response. The goal is to help…

This study collects information on side effects and how well the cancer responds in 170 advanced cancer patients receiving anti-VEGF therapy. The goal is to see if certain side effects are linked to better or worse treatment outcomes. No new treatment is being tested; this is an …

This study aims to test an educational tool designed for people with melanoma who also have an autoimmune disease (like rheumatoid arthritis or Crohn's disease) and are considering treatment with immune checkpoint inhibitors. Researchers will ask about 125 patients and their doct…

This study is creating a simple guide (decision aid) for people with advanced cancer who have already tried several treatments. The goal is to help them have better conversations with their doctors about whether to continue treatment. About 155 patients and doctors will help deve…

This study is building a registry of 200 people with stage III or IV inflammatory breast cancer. Researchers will collect data from participants who have had or plan to have a blood test called Signatera (MRD testing) and may have breast surgery. The goal is to gather information…

This study brings together a panel of prostate cancer experts to agree on the most important pieces of information that should be included in medical reports. The goal is to create a standard way of reporting key data in electronic health records, which could help doctors better …

This pilot study looks at how often women experience posttraumatic stress disorder (PTSD) after gynecologic brachytherapy, a type of internal radiation. Researchers want to find better ways to keep patients comfortable and reduce psychological distress when the treatment applicat…

This study looks at why some head and neck cancer patients stick with swallowing exercises after radiation, while others don't. Researchers will use blood tests and questionnaires to explore how immune proteins, emotions, and social support affect a patient's ability to follow th…

This study watches 40 colorectal cancer patients who have no visible tumors but still have cancer DNA in their blood (minimal residual disease). Researchers will see how biomarker-directed therapy, chosen by each patient's own doctor, affects this cancer DNA over time. The goal i…

This study looks at how the breast cancer drug tamoxifen affects certain immune cells called neutrophils. It focuses on a process where these cells create web-like structures (NETs) that may cause side effects. Researchers will measure NET levels in blood samples from 290 women w…

This study aims to learn how patients rate their symptoms during or after radiation therapy using different questionnaires. Researchers want to see if different rating scales give similar or different results. The study involves 300 adults with head and neck cancer who are curren…

This study compares two types of 3D mammography (digital breast tomosynthesis) to see which one makes breast masses and distortions easier to see. About 100 women getting standard screening mammograms will participate. The goal is to improve detection, not to treat any disease.

This study looks at certain lung cells in people who have developed bronchiolitis obliterans syndrome after a stem cell or lung transplant. Researchers want to learn more about these abnormal cells to help doctors spot the condition earlier in future patients. The study involves …

This study is testing whether a blood test, called a liquid biopsy, can find cancer cells and predict if endometrial cancer will return. Researchers will collect blood and tissue samples from 1,000 women with endometrial cancer before and after treatment. The goal is to see if th…

This study works with community groups to find Black individuals who may benefit from genetic testing for breast and colorectal cancer. Participants fill out a simple risk questionnaire and can receive genetic counseling and testing remotely. The goal is to help people understand…

This study aims to understand how social and financial challenges influence the results of transplant and cell therapy treatments. Researchers will follow 2,000 adult patients at MD Anderson Cancer Center and ask them about their social circumstances. The goal is to identify barr…

This study is testing an educational tool to help men aged 65 and older who are on active surveillance for prostate cancer talk with their doctors about possibly reducing follow-up tests like biopsies or scans. The goal is to see if the tool is easy to use and helps men make info…

This study watches children aged 2 to 12 who are getting radiation therapy for cancer. Researchers want to see how their anxiety changes over time. The goal is to learn more about their emotional needs, not to test a new treatment.

This study surveys 250 U.S. lung specialists to learn how the COVID-19 pandemic changed their procedures, staffing, and clinic operations. The goal is to help pulmonary programs improve and guide future research for better pandemic preparedness. Participants are pulmonologists wh…

This study reviews the medical charts of up to 3,000 people with chronic myeloid leukemia (CML) who received standard tyrosine kinase inhibitor drugs (like imatinib) outside of a clinical trial. The goal is to learn how these patients respond to treatment in real-world settings, …

This study looks at whether crushing belumosudil tablets and mixing them in water changes how the drug is absorbed in people with chronic graft-versus-host disease (cGVHD). Eight adults who have had a stem cell transplant will take the drug as a whole tablet and as a crushed tabl…

This study explores whether a simple blood test that measures tumor DNA (ctDNA) can help doctors decide if patients with colorectal or appendix cancer need stronger or weaker chemotherapy before surgery. About 48 adults with cancer that has spread to the abdomen will take part. T…

This study looks at how the COVID-19 pandemic changed out-of-pocket costs, lost wages, and economic strain for 600 breast cancer patients having surgery. Researchers want to understand the financial challenges these patients face, especially those who also had breast reconstructi…

This study is a registry that gathers information from 250 people with lung cancer or cancer that has spread to the lungs. Participants will have their tumors treated with a robotic scope inserted through the mouth to burn the tumor. The goal is to learn how well this procedure w…

This study is testing whether a specially designed video game can help young people (ages 15-39) who have had a stem cell transplant for leukemia or lymphoma improve their health habits. Researchers will gather feedback from 40 participants to see if the game is easy and enjoyabl…

This study is following over 2,300 people across the US to better understand chronic pancreatitis, a painful long-term condition of the pancreas. Researchers will track participants' symptoms and disease changes over time to identify what causes the disease and how it progresses.…

This study looks at how sleep and physical activity change for blood cancer patients and their caregivers after a stem cell transplant. Researchers will ask 66 patient-caregiver pairs to fill out questionnaires about sleep, mood, fatigue, and quality of life. The goal is to under…

This study is testing a special type of MRI scan to see if it can better measure how colorectal cancer liver tumors respond to chemotherapy. About 70 people with liver metastases that have not been treated yet will get the scan before and after chemo. The goal is to improve how d…

This study looks at whether joining a support community can improve emotional well-being and reduce feelings of isolation for people with neuroendocrine cervical cancer (NECC). About 40 participants will fill out questionnaires about their health and feelings. The goal is to unde…

This study looks at whether a decision-making tool helps women newly diagnosed with early-stage breast cancer decide if they want preventive mastectomy on their healthy breast. About 15 participants will use the tool and rate how clear and balanced it is. The goal is to see if th…

This study is collecting information from 2000 bladder cancer patients who have had their bladder removed (radical cystectomy). Researchers want to understand how patients recover by tracking symptoms and outcomes reported by patients and doctors. The goal is to use this informat…

This study looks at whether measuring a patient's energy reserve (fitness) before major cancer surgery can help predict how well they recover. Researchers will test 200 adults with abdominal or pelvic cancer using a special exercise test to measure gas exchange. The goal is to de…

This study is testing a new software that uses fMRI scans to create detailed maps of important brain areas, like those controlling language and movement, in people with brain tumors. The goal is to help surgeons plan safer and more precise tumor removal. The study will involve up…

This study follows 100 people who were diagnosed with mycosis fungoides or lymphomatoid papulosis before age 20. Researchers will check their health over time and ask about long-term outcomes. The goal is to learn more about how these rare skin conditions affect patients as they …

This study collects information from 125 people with von Hippel-Lindau (vHL) disease to track how the disease progresses, what treatments they receive, and how it affects their quality of life. No new treatments are tested; instead, researchers gather data to better understand th…

This study interviews cancer care providers, patients, and caregivers to learn their thoughts and feelings about receiving hospital-level care at home. The goal is to understand what people know and believe about home hospital care, so that future programs can be designed to bett…

This study looks at how the COVID-19 pandemic impacted the emotional, financial, and physical well-being of 600 adolescent and young adult cancer patients and survivors. Researchers want to understand their stress and health changes during the pandemic. The goal is to use this in…