M.d. Anderson Cancer Center

This study tests whether eating prebiotic-rich foods can improve how well immunotherapy works in people with advanced melanoma that cannot be removed by surgery. About 75 adults starting standard immunotherapy will follow a special diet for several weeks. Researchers will check i…

This study tests whether ultra low doses of radiation can control skin lesions in people with mycosis fungoides, a type of lymphoma. About 50 participants will receive targeted radiation to their skin spots. The goal is to see if this gentler approach works as well as standard do…

This study tests whether combining three drugs—tretinoin, arsenic trioxide, and gemtuzumab ozogamicin—works better than standard treatment for adults newly diagnosed with acute promyelocytic leukemia (APL). About 151 participants will receive the drug combination. The goal is to …

This study tests whether giving two immunotherapy drugs (tiragolumab and atezolizumab) before and after standard surgery and chemoradiation can better control advanced oral cancer. It includes 29 adults with newly diagnosed stage 3-4 oral cavity squamous cell carcinoma that has a…

This study tests whether two drugs, pembrolizumab and lenvatinib, can shrink brain tumors in people with breast cancer, lung cancer, or other solid tumors that have spread to the brain. About 104 participants will receive the combination therapy. The main goal is to see how many …

This early-stage trial tests whether a specially engineered herpes virus (G207) is safe for children whose cerebellar brain tumors have come back or not responded to standard treatments. The virus is injected directly into the tumor, and a small dose of radiation is given to help…

This study tests whether giving two drugs (cemiplimab and cetuximab) before salvage surgery can help control recurrent oral cavity squamous cell carcinoma. It involves 17 adults whose cancer has returned at least 3 months after prior treatment. The main goals are to check safety …

This study tests a drug called asciminib in 40 adults with chronic myeloid leukemia (CML) whose first treatment did not work well or caused side effects. The goal is to see if asciminib can lower the amount of leukemia cells in the blood to very low levels within 12 months. Parti…

This study tests whether combining two drugs, axicabtagene ciloleucel and glofitamab, can help control large B cell lymphoma in patients whose cancer returned or didn't respond to initial treatment. About 40 adults will receive this combination as a second-line therapy. The main …

This study tests whether adding the chemotherapy drug bendamustine to standard care can prevent graft-versus-host disease (GVHD) in people with blood cancers who receive a stem cell transplant. About 25 participants will get bendamustine with or without another drug, cyclophospha…

This study tests whether adding special cells from donated cord blood to a standard drug (ruxolitinib) can better control severe graft-versus-host disease (GVHD) that hasn't responded to steroids. GVHD is a serious complication where donor immune cells attack the patient's body a…

This early-phase trial tests a combination of two drugs, gemcitabine and nab-sirolimus, in people with advanced leiomyosarcoma or soft-tissue sarcoma that has a specific genetic change (TSC1 or TSC2 mutation). The main goal is to find a safe dose and see how well the body tolerat…

This study tests a two-drug combination—CPX-351 (a stronger form of standard chemo) and quizartinib (a targeted pill)—in people with acute myeloid leukemia (AML) or high-risk myelodysplastic syndrome (MDS). The goal is to find the safest dose and see if the combo can control the …

This study tests a combination of two drugs, enasidenib and azacitidine, in people whose acute myeloid leukemia (AML) has returned or not responded to prior treatment and who have a specific IDH2 gene mutation. The goal is to see if the combination can shrink or control the cance…

This study tests whether adding an experimental drug called CTX-009 to standard chemotherapy and immunotherapy can help control advanced bile duct cancer. About 50 adults with cancer that cannot be removed by surgery or has spread will receive the combination. The main goal is to…

This study is testing a combination of two drugs, azacitidine and quizartinib, for adults with certain blood and bone marrow cancers (like MDS and CMML) that have specific FLT3 or CBL genetic mutations. The goal is to find the safest and most effective dose and to see how well th…

This study tests a combination of drugs (venetoclax, cladribine, low-dose cytarabine, and azacitidine) for adults aged 50 and older with untreated acute myeloid leukemia (AML). The goal is to see if this approach can achieve complete remission. Participants receive an initial tre…

This study is for people with newly diagnosed multiple myeloma who have already had a stem cell transplant. It tests whether adding a targeted drug (belantamab mafodotin) to standard lenalidomide maintenance can clear any remaining cancer cells that are still detectable (MRD-posi…

This early-stage study tests a new drug called HC-7366 in 18 adults with acute myeloid leukemia (AML) that has returned or not responded to treatment. The main goal is to find a safe dose and understand side effects. Researchers will also watch for any signs that the drug helps c…

This study is for people with acute myeloid leukemia (AML) that has a specific genetic change called an IDH1 mutation. It tests a combination of three drugs: decitabine, venetoclax, and olutasidenib. The goal is to find a safe dose and see if the combination helps control the dis…

This study tests whether combining olutasidenib with other targeted drugs is safe and tolerable for people whose blood cancer (like AML or MDS) has returned or not responded to treatment. Participants must have both an IDH1 mutation and another mutation in a signaling pathway gen…

This study tests whether combining two drugs, dostarlimab and LB-100, can help control ovarian clear cell carcinoma, a rare and hard-to-treat cancer. About 21 adults aged 18-75 with recurrent clear cell ovarian, peritoneal, or fallopian tube cancer will receive the treatment. The…

This early-stage trial tests the safety and effectiveness of pembrolizumab, an immunotherapy drug, in people with thymoma or thymic carcinoma that cannot be surgically removed. The drug helps the immune system attack cancer cells. About 37 participants will receive the treatment …

This study tests a drug called canakinumab in people with low- or intermediate-risk myelodysplastic syndromes (MDS) or chronic myelomonocytic leukemia (CMML). The drug is an antibody that may slow cancer growth. About 76 adults will receive injections to see if it improves blood …

This study tests whether giving methylnaltrexone for two weeks before surgery is safe for people with oral cavity squamous cell carcinoma. About 25 adults with early to advanced cancer that can be removed by surgery will take the drug. The main goal is to check for side effects a…

This study tests whether combining two antiviral drugs, baloxavir and oseltamivir, works better than oseltamivir alone for severe flu in people who have had a stem cell transplant or have blood cancer. About 60 participants will be followed for 30 days to see if the combo reduces…

This study tests whether combining zanzalintinib and pembrolizumab can help control certain types of advanced soft-tissue sarcoma that have spread. About 20 adults with specific sarcoma subtypes will receive the drug combination. The main goal is to check safety and side effects,…

This study tests a treatment called Y-90 radioembolization given before liver surgery for people with colorectal cancer that has spread to the liver. The goal is to shrink tumors on the right side of the liver and help the left side grow larger so surgery can be safer and more ef…

This early-stage trial tests a modified cold virus (DNX-2401) that is designed to target and kill brain cancer cells. The virus is loaded into donor stem cells and injected into the artery that feeds the tumor. The study includes 36 adults with recurrent high-grade glioma and aim…

This study is for people with stage IV cancer that has started to grow in only a few places (oligoprogression). It tests whether adding local treatments like radiation, surgery, or other procedures to all growing spots can help control the disease better than switching to a new s…

This study tests whether adding metal-detoxifying drugs to standard chemotherapy can improve outcomes for people with certain types of acute myeloid leukemia (AML). Researchers believe that lowering metal levels in the blood and bone marrow may help control the disease or make ch…

This early-stage study is testing whether adding the drug talazoparib to radiation therapy is safe and effective for people whose gynecologic cancers (like ovarian, endometrial, or cervical) have come back. The goal is to find the best dose that limits side effects while potentia…

This study tests a new treatment for people with blood cancers that have come back or not responded to standard therapy. It uses specially engineered natural killer (NK) cells from donated cord blood, designed to target a protein called CD5 on cancer cells. Up to 64 participants …

This early-phase trial tests a new treatment for glioblastoma, an aggressive brain cancer that has returned after standard therapy. The treatment uses natural killer (NK) immune cells from donated cord blood that have been genetically modified to resist signals that normally shut…

This study tests whether adding the drug venetoclax to standard chemotherapy (FLAG-IDA) can better treat acute myeloid leukemia (AML) that is newly diagnosed or has returned. About 116 adults with AML or high-risk MDS will receive the combination. The goal is to find the best dos…

This early-phase trial is testing a new type of high-dose radiation called HYDRA for people with laryngeal (voice box) cancer. The main goal is to find the highest safe dose and check for side effects. About 11 adults with early-stage squamous cell carcinoma of the larynx will re…

This study tests whether giving very low doses of radiation before or after chemotherapy-free targeted therapy can help control mantle cell lymphoma that has returned or stopped responding to treatment. About 80 adults with this type of lymphoma will receive ultra low dose radiat…

This study tests a new treatment called KSQ-004EX for people with advanced solid tumors that have not responded to standard therapies. The treatment uses a patient's own immune cells, which are collected, genetically modified to be stronger, and then infused back. The goal is to …

This early-phase trial tests a combination of specially engineered immune cells (TROP2-CAR-NK cells) and a targeted drug (cetuximab) in adults with colorectal cancer that has minimal residual disease—meaning small amounts of cancer remain after treatment. The main goal is to find…

This early-phase study tests whether adding healthy donor natural killer (NK) cells to the usual drugs azacitidine and venetoclax can better control acute myeloid leukemia (AML). About 32 adults with AML that has returned or not responded to treatment will receive the combination…

This study tests a combination of three drugs—pirtobrutinib, venetoclax, and obinutuzumab—in people with chronic lymphocytic leukemia (CLL) or Richter transformation (RT) who haven't had treatment before. The goal is to see if this time-limited therapy is safe and effective at co…

This early-phase study tests whether adding the HIV drug nelfinavir to standard chemotherapy (cisplatin) and radiation can safely treat locally advanced vulvar cancer that cannot be surgically removed. About 25 adults with stage II–IVA vulvar cancer will receive different doses o…

This study is for older or frail adults with newly diagnosed diffuse large B-cell lymphoma (DLBCL) who cannot receive standard strong chemotherapy. It tests adding a drug called epcoritamab to a gentler chemo regimen (R-miniCVP) to see if it helps control the cancer. About 40 par…

This study tests a new drug combination for people with follicular lymphoma whose cancer has returned or not responded to prior treatment. About 60 adults will receive valemetostat along with rituximab and lenalidomide. The goal is to find the safest dose and see how well the com…

This study tests whether adding olutasidenib to standard chemotherapy can better control certain blood cancers (MDS, CMML, or MPN) in people with an IDH1 gene mutation. About 45 adults with high-risk disease will receive the combination and be monitored for safety and response. T…

This study tests whether combining two drugs, tucatinib and T-DM1, can control HER2-positive solid tumors that have spread to the brain. About 30 adults with this condition will receive the treatment to see if it shrinks or stops tumor growth. The main goal is to check safety and…

This study looks at whether a flexible MRI coil can accurately detect aggressive prostate cancers without needing a probe inside the body. About 258 men with intermediate- or high-risk prostate cancer will get an MRI before surgery. The goal is to see if this less invasive approa…

This study looks at whether a special MRI scan can help doctors predict a serious side effect called osteoradionecrosis (bone death) in people with head and neck cancer who are getting radiation therapy. About 1,400 participants will have MRI scans before, during, and after treat…

This early-phase study tests a new imaging agent called 18F-4FN for PET scans. It aims to safely detect inflammation in patients with endocrine tumors who are on immunotherapy. The agent works by reacting with high-energy molecules produced by inflammatory cells, making inflamed …

This study tests whether contrast-enhanced mammography (CEM) can find breast cancers that standard mammography might miss in women with dense breasts. About 1,000 women aged 30-75 with dense breasts will get both types of mammograms. The goal is to see if CEM improves early detec…

This early-phase study tests a special imaging agent, hyperpolarized carbon C 13 pyruvate, to see if it helps doctors diagnose glioma, a type of brain tumor, more accurately. About 13 adults with brain tumors will receive the agent before an advanced MRI scan. The goal is to impr…

This study is testing a new point-of-care HPV test that requires less equipment than current tests, which could make screening more available. Researchers will compare the new test's accuracy to standard lab tests in 600 adults with a cervix. If successful, this could help more p…

This study looks at a two-step surgery to prevent ovarian cancer in women with high-risk gene mutations (like BRCA1/2). Instead of removing both ovaries and fallopian tubes at once, the first step removes only the fallopian tubes, and the ovaries are removed later. The goal is to…

This study tests whether a special yoga program can improve physical function, fatigue, sleep, mood, and quality of life for people with lung or esophageal cancer who are getting radiation therapy, and also for their family caregivers. About 400 patient-caregiver pairs will take …

This study tests whether adding cryoablation (freezing cancer cells with special needles) to standard radiation therapy provides better pain relief for people with cancer that has spread to their bones. About 40 adults with various advanced cancers (like prostate, kidney, or mela…

This study looks at whether a special geriatric care program can help older adults (65+) who have finished treatment for early-stage breast cancer feel better and have a higher quality of life. Participants will receive a full health check and survivorship visits. The goal is to …

This study tests whether combining a nerve pain medication (duloxetine) with neurofeedback brain training works better than either treatment alone for chemotherapy-induced nerve damage. About 380 adults with nerve pain from cancer treatment will participate. The goal is to reduce…

This study looks at how well certain medications (haloperidol, chlorpromazine, valproic acid) or a placebo can calm agitated delirium in cancer patients who are in the hospital. The goal is to find better ways to reduce distress and suffering from delirium. About 42 adults with a…

This study tests two surgical techniques—TMR and RPNI—alone or together to reduce long-term pain and phantom limb pain in cancer patients who have had an amputation. About 45 adults will be randomly assigned to one of three surgery groups. The goal is to see which approach works …

This early-phase study tests whether a non-invasive brain stimulation technique called rTMS can help people with impulse control disorders who struggle with overeating. Researchers will enroll 30 adults aged 21 to 60 with a BMI over 30. The main goal is to check safety and see if…

This early-phase study is testing whether a minimally-invasive procedure using special light-activated nails can stabilize pelvic bone tumors and improve patients' ability to function. About 50 adults with cancer that has spread to the pelvis will receive the procedure. The main …

This study looks at whether women aged 60 and older with early-stage, low-risk breast cancer can safely skip hormone therapy after lumpectomy and just receive radiation. The goal is to see if this approach maintains good disease control while improving quality of life by avoiding…

This study looks at how safe and helpful a procedure called portal vein stenting is for people with gastrointestinal cancer who have a narrowed portal vein. Researchers will track how long the stent keeps the vein open and how it affects patients' overall health, nutrition, and q…

This study looks at whether a simple fitness test before major cancer surgery can help predict how well a patient will recover. Researchers will measure energy use during exercise in 200 adults with abdominal or pelvic cancer. The goal is to see if this test can identify patients…

This study compares two types of 3D mammography (wide-angle vs. narrow-angle) to see which one makes breast masses and distortions easier to see. About 100 women getting routine screening mammograms will participate. The goal is to improve breast cancer detection, not to test a n…

This study tests whether an 8-week program of text messages sent to your phone can help you sit less and be more active. About 200 adults who sit for more than 6 hours a day will take part. They will wear a Fitbit to track their movement and receive texts with tips and encouragem…

This study builds a database of 1,000 breast cancer survivors aged 50 or younger who have dense breast tissue. Participants will get routine MRI scans alongside their regular mammograms. Researchers hope to learn whether MRI helps find new cancers earlier in dense tissue, which i…

This study reviews medical records from 600 lung cancer patients who had lung surgery between 2004 and 2019. Researchers want to see if the use of robotic surgery has led to more atypical segmentectomies, a type of partial lung removal. The goal is to understand trends in surgica…

This study is for 1,000 people with oral cancer or precancerous mouth lesions. Researchers will collect tissue samples and ask about symptoms before, during, and after treatment. The goal is to find markers that can predict how well a person will respond to therapies like surgery…

This study tests a method called 'Teaching the Teachers' to see if it helps spread liver cancer diagnosis guidelines. Experts are taught the guidelines first, then they teach other doctors. The goal is to see if this approach increases how often the guidelines are used by radiolo…

This study looks at how different ways of presenting medical information influence the treatment choices of people with advanced cancer. Researchers will enroll 400 adults with advanced solid tumors or aggressive lymphoma who have already tried at least two cancer therapies. The …

This study looks at why people with head and neck cancer do or don't follow through with swallowing exercises after radiation. Researchers will use blood tests to check immune proteins and questionnaires to understand patients' feelings, pain, and support. The goal is to find way…

This study looks at how often women experience posttraumatic stress disorder (PTSD) after undergoing gynecologic brachytherapy, a type of internal radiation for cancer. Researchers want to find better ways to make the removal of the treatment implants more comfortable and less di…

This study tracks memory and thinking changes in 100 adults with blood cancers who receive whole brain radiation. Researchers will test cognitive skills and quality of life over time to better understand the side effects of this treatment. The goal is to learn, not to test a new …

This study tests whether a CPAP machine (which gently pushes air into the lungs) can reduce tumor movement during lung cancer radiation therapy better than the standard deep-breath-hold technique. About 30 people receiving stereotactic body radiation therapy (SBRT) will participa…

This study is testing a new screening tool called SOCS-OTS to see if it correctly identifies cancer survivors who need occupational therapy (OT). Researchers will compare the tool's results with a standard screening method already used at MD Anderson Cancer Center. About 80 adult…

This study looks at abnormal cells in the lungs of people who developed bronchiolitis obliterans syndrome after a stem cell or lung transplant. Researchers want to learn if these cells can help spot the disease earlier in future patients. The study involves 15 participants and us…

This study looks at how people with two early blood conditions—MGUS and smoldering myeloma—feel day to day. Researchers will ask 400 participants to fill out short questionnaires about their quality of life. The goal is to learn what symptoms and worries are most common, so docto…

This study follows 100 men with low- or very low-risk prostate cancer who choose active surveillance (monitoring instead of immediate treatment). Researchers will track disease progression over 5 years using remote symptom monitoring and build a tissue and data bank to help under…

This study tests whether an abbreviated food tracking app called MySnackTracker works as well as traditional full-intake food tracking. Researchers will compare how satisfied and consistent 90 participants are with each method. The goal is to see if a simpler approach can make di…

This study looks at work-related stress in surgeons and musicians. Researchers will use wearable brain monitors, saliva tests, and questionnaires to measure stress. The goal is to learn how high-pressure jobs affect the body and mind. About 20 adults will take part.

This study reviews the medical charts of up to 3,000 people with chronic myeloid leukemia (CML) who received standard tyrosine kinase inhibitor drugs (like imatinib, dasatinib, or nilotinib) outside of a clinical trial. The goal is to learn how these patients respond to treatment…