M.d. Anderson Cancer Center

This study tested a new way to deliver radiation therapy for central lung tumors using MRI guidance. The goal was to see if it is safe and can control tumors better than standard CT-guided radiation. Only 3 people took part before the study was stopped early.

This study tested a combination of two drugs, venetoclax and azacitidine, in 34 adults with high-risk blood cancers (MDS or CMML) that returned or didn't respond to earlier treatment. The goal was to find the safest dose and see if the combo could shrink or control the cancer. Th…

This study tested a combination of two drugs, apalutamide and abiraterone, along with prednisone, in men whose prostate cancer had spread and stopped responding to standard hormone therapy. The goal was to see if this combination could slow cancer growth. Only 7 men took part bef…

This study tested a combination of two drugs, bintrafusp alfa and pimasertib, in people whose cancer had spread to the brain. The goal was to find the safest dose and see if the treatment could slow or stop the cancer from growing. The trial was stopped early after enrolling only…

This study tested whether adding the targeted drug inotuzumab ozogamicin before and after a stem cell transplant could help control leukemia and lymphoma. It included 15 people aged 12 to 75 with certain blood cancers. The study was stopped early, but researchers looked at safety…

This study tested whether the drug ofatumumab could control chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) that remains after chemotherapy. Only 4 people took part before the study was stopped early. The goal was to see if the drug could reduce or eliminat…

This early-phase trial aimed to test the safety of combining two drugs, adagrasib and olaparib, in people with advanced solid tumors that have a specific KRAS G12C mutation. The study focused on certain cancers like gynecological, breast, pancreatic, and a type of lung cancer. Ho…

This study tested a new drug combination for people with metastatic melanoma (skin cancer that has spread). The goal was to find a safe dose of an experimental drug (APX005M) injected directly into tumors, combined with an approved immunotherapy (pembrolizumab) given through the …

This study tested a new drug (BMS-986218) plus nivolumab and targeted radiation in people with advanced solid tumors that had spread. The goal was to see if this combination could help the immune system fight cancer better. Only 13 people took part before the study was stopped ea…

This study looked at whether removing liver tumors with surgery, along with chemotherapy, helps people with colorectal cancer that has spread to the liver and lungs live longer compared to chemotherapy alone. The trial was stopped early after enrolling only 29 participants. The r…

This study tested the drug erdafitinib in 11 men with advanced prostate cancer that had spread to the bones and stopped responding to hormone therapy. The goal was to see if erdafitinib could help control the cancer by blocking certain growth signals. Researchers also collected b…

This early-phase study tested a treatment using donated natural killer (NK) cells from cord blood, combined with chemotherapy, for children and young adults with solid tumors that returned or didn't respond to standard care. The goal was to find the safest dose and check for side…

This study tested a combination of two drugs, futibatinib and pembrolizumab, in people with a hard-to-treat type of advanced endometrial cancer called microsatellite stable (MSS). The goal was to see if the combo could shrink tumors or slow the cancer. The trial was stopped early…

This study tested two immunotherapy drugs, nivolumab and ipilimumab, in 10 people with a rare and aggressive kidney cancer called renal medullary carcinoma. The goal was to see if the combination could shrink tumors or stop them from growing. The trial was stopped early, but the …

This study looked at whether a less invasive surgery (conservative surgery) could safely treat women with early-stage, low-risk cervical cancer. The goal was to see if this approach causes fewer side effects and helps recovery. The study included 137 women with stage IA2 or IB1 c…

This study tested a combination of two drugs—ipilimumab (an approved immunotherapy) and MGN1703 (an experimental immune booster)—in people with advanced solid tumors that had stopped responding to standard treatments. The main goal was to find the safest dose of MGN1703 when give…

This early-phase study tested a drug called plinabulin combined with radiation and immunotherapy in 19 people with advanced cancers (like lung, bladder, or melanoma) that had stopped responding to standard immunotherapy. The goal was to see if the combo could shrink tumors or con…

This early-phase trial tested whether adding the experimental drug YL-13027 to standard chemotherapy (gemcitabine and nab-paclitaxel) is safe for people with advanced pancreatic cancer that no longer responds to treatment. Only 4 participants were enrolled before the study was st…

This phase 2 study tested a combination of two immunotherapy drugs (ipilimumab and nivolumab) plus radiation therapy in 37 patients with advanced HPV-positive throat cancer. The goal was to see if the treatment was safe and could shrink or eliminate tumors. The study was terminat…

This study tested a new treatment for head and neck cancer that has come back or spread. It combined a drug called NBTXR3 (activated by radiation) with the immunotherapy pembrolizumab. The goal was to see if this combination could shrink tumors and help patients live longer. The …

This study tested whether adding a new drug (ABL001) to standard CML therapy could help patients with small amounts of remaining leukemia. Only 7 people took part before the study was stopped early. The goal was to see if the combination could improve molecular responses and poss…

This study tested whether giving the immunotherapy drug pembrolizumab after radiation therapy could help people with a rare and aggressive thyroid cancer (anaplastic thyroid carcinoma) that had not yet spread beyond the neck. Only 6 people took part before the trial was stopped e…

This study tested two drugs, nab-paclitaxel and alpelisib, given before surgery to people with a fast-growing type of breast cancer (triple-negative) that didn't respond to standard chemo. The goal was to shrink tumors before surgery. Only 6 people took part before the study was …

This study tested a drug called vibecotamab in adults with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) whose cancer did not respond to or came back after standard treatments. The drug is a special antibody designed to help the immune system attack cancer cells.…

This study tested whether giving patients their own immune cells (lymphocytes) after chemotherapy and radiation could help restore their immune system. It included 19 adults with non-small cell lung cancer or esophageal cancer. The approach aimed to improve immune health, but the…

This study tested a combination of three drugs—magrolimab, azacitidine, and venetoclax—in 110 adults with acute myeloid leukemia (AML) that had come back or not responded to treatment. The goal was to find the best dose and see if the combination could control the disease. The tr…

This study tested a mix of targeted drugs (neratinib, pertuzumab, trastuzumab) and chemotherapy (paclitaxel) in people with advanced or inflammatory breast cancer. The goal was to find the best dose and see if the combination could shrink tumors before more chemo. The study was s…

This study tested a combination of the experimental drug magrolimab with cetuximab and either pembrolizumab or docetaxel in people with head and neck cancer that had come back or spread. Only 4 people enrolled before the trial was stopped early. The goal was to see if the combo c…

This early-stage study tested the safety of a drug called itacitinib in 8 adults who developed bronchiolitis obliterans syndrome (a type of lung scarring) after receiving a stem cell transplant from a donor. The goal was to see if the drug could help control the lung disease by b…

This study tested a combination of two drugs, venetoclax and azacitidine, for people with a high-risk type of bone marrow cancer called myelodysplastic syndrome (MDS) that either came back or didn't respond to treatment. The goal was to find the best dose and see how well it work…

This study tested the drug ponatinib in 51 adults with a fast-growing form of chronic myeloid leukemia (CML) who had little or no prior treatment. The goal was to see if ponatinib could control the disease by blocking a protein that drives leukemia growth. However, the drug can c…

This study tested whether adding the drug ponatinib to a standard chemotherapy regimen plus venetoclax could help people with relapsed or refractory T-cell acute lymphoblastic leukemia achieve remission. Only 4 participants were enrolled before the trial was stopped early. The go…

This study looked at adding a targeted drug called venetoclax to low-intensity chemotherapy for adults with acute lymphoblastic leukemia (ALL) that came back or didn't respond to treatment. The goal was to find the safest dose and see if the combination could help control the dis…

This study tested a drug called poziotinib in 93 people with advanced non-small cell lung cancer that had specific gene mutations (EGFR or HER2). The goal was to see if the drug could shrink tumors. The study was stopped early, but it aimed to provide a new treatment option for p…

This study tested a drug called ADCT-602 in 37 people with a type of blood cancer (B-cell acute lymphoblastic leukemia) that had returned or stopped responding to other treatments. The drug is a lab-made antibody that targets a protein (CD22) on cancer cells to stop them from gro…

This study tested a new drug (repotrectinib) alone or with another drug (fulvestrant) in 6 people with a specific advanced breast cancer called metastatic invasive lobular carcinoma. The goal was to see if the combination could control the cancer after prior treatments failed. Th…

This study looked at whether the drug belantamab mafodotin (Blenrep) could help prevent multiple myeloma from returning after a patient's own stem cell transplant. Only 6 people took part, and the study was stopped early. The main goals were to check safety and pain levels, not t…

This study tested whether combining two drugs, CB-103 and venetoclax, could help control T-cell acute lymphoblastic leukemia (T-ALL) in teens and young adults whose cancer had come back or not responded to treatment. Only 2 people enrolled before the trial was stopped early. The …

This early-stage study tested the drug pomalidomide in 15 people with Waldenstrom macroglobulinemia, a rare blood cancer, that had returned or stopped responding to prior treatments. The main goal was to find the safest dose and watch for side effects. Researchers also tracked ch…

This study tested a combination of two drugs, omacetaxine and venetoclax, in 24 adults with relapsed or treatment-resistant acute myeloid leukemia or myelodysplastic syndrome that had a specific genetic change called RUNX1. The goal was to find the best dose and see if the combo …

This study tested a combination of two drugs, venetoclax and decitabine, in people with acute myeloid leukemia (AML) or related blood cancers that were either newly diagnosed in older adults or had come back after treatment. The goal was to see how well the drugs worked together …

This study tested a combination of two drugs (copanlisib and fulvestrant) in people with advanced ovarian, endometrial, or breast cancers that are hormone receptor-positive and have certain gene changes. Only 7 people took part before the study was stopped early. The main goals w…

This early-phase study tested combinations of three drugs—bevacizumab, temsirolimus, and either valproic acid or cetuximab—in 154 people with advanced cancers or certain non-cancerous but progressive diseases. The main goal was to find the safest dose and see how well the drugs w…

This study tested whether adding pirtobrutinib to venetoclax could clear remaining cancer cells in people with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) who still had detectable disease after venetoclax alone. Only 3 adults took part before the trial …

This study tested a combination of two drugs, sitravatinib and nivolumab, in people with advanced kidney cancer that had spread and worsened after prior treatment. The goal was to see if the combination could shrink tumors or slow the disease. The study was stopped early after en…

This study tested whether a combination of daratumumab and pomalidomide could help control multiple myeloma that has returned after a stem cell transplant. The trial included 13 adults with relapsed disease. The goal was to see if this maintenance therapy could achieve complete r…

This early-phase study tested whether special PET scans using glutamine and FSPG can better detect tumors in people with advanced colorectal cancer. Six participants received these imaging agents, and researchers compared the results to standard CT or MRI scans. The study was ter…

This study tested whether a combination of levocarnitine (an amino acid) and vitamin B complex could lower high bilirubin levels caused by certain leukemia drugs. Only 10 adults with acute lymphoblastic leukemia took part. The trial was stopped early, so results are limited.

This study looked at the quality of life of women who were pregnant while being treated for breast cancer. Researchers used questionnaires to gather information from survivors who are now cancer-free. The goal was to understand their well-being after such a challenging experience…

This study gathered information from 499 penile cancer patients to better understand the disease, its risk factors, treatments, and outcomes. No new treatments were tested. The goal was to create a database to help doctors spot trends and improve future care.

This study looked at whether repeated MRI scans and blood tests can predict changes in thinking and memory after brain radiation. Nine adults with brain tumors who were scheduled for radiation took part. Researchers hoped to find better ways to monitor and adjust treatment, but t…

This study looked at whether a simple finger device (Vendys II) can measure blood vessel health in children and young adults (ages 6-26) getting a stem cell transplant. The device works by briefly stopping blood flow and then tracking how the finger warms back up. The study was s…

This study aimed to see if an oral (pill) form of the drug cladribine works as well as the standard IV (intravenous) form in people with certain blood cancers like leukemia. Only 3 people took part before the study was stopped early. The main goal was to check safety and how the …

This study aimed to help low-income pregnant women stop smoking and make their homes smoke-free. Smoking during pregnancy raises the risk of cancer and can lead to low birth weight and other health problems for the baby. The program offered support and referrals to services durin…