M.d. Anderson Cancer Center

This study tests a combination of two drugs, zanzalintinib and cemiplimab, in people with a rare and fast-growing thyroid cancer called anaplastic thyroid cancer that has a specific gene type (BRAF wild-type). The goal is to see if this treatment can extend survival by about 4 mo…

This study tests a drug called sacituzumab tirumotecan in 20 people with advanced anal or rectal cancer that has spread or cannot be removed and has not responded to prior treatments. The main goal is to see if the drug is safe and what side effects it causes. This is an early-ph…

This early-phase study tests a new treatment for people with advanced breast cancer that has stopped responding to standard therapies. It combines specially engineered immune cells (TRICK-NK) with a targeted drug (T-Dxd) to try to control the disease. The study will enroll about …

This early-phase study tests two drugs, blinatumomab and revumenib, given together to adults with a rare and aggressive form of acute lymphoblastic leukemia (ALL) that has a specific genetic change called KMT2A rearrangement. The main goal is to find a safe dose and understand si…

This early-phase study tests a new drug called REC-617 in 15 people with a rare type of soft tissue cancer (leiomyosarcoma) that has spread or cannot be removed and has lost a key protein called RB1. The main goal is to check the drug's safety and see if it can help control the c…

This study tests whether adding nivolumab to standard chemotherapy (AVD) can better control early-stage Hodgkin lymphoma in patients aged 2 to 21. The treatment is given to 15 participants to see if it is safe and effective. The goal is to improve outcomes while reducing long-ter…

This early-phase study tests two drugs together—navlimetostat and pumitamig—in people with advanced non-small cell lung cancer that has a specific genetic change (MTAP-deficient). The main goal is to find a safe dose and see if the combination helps shrink tumors. About 17 adults…

This early-phase study tests a new treatment called LNK001 for people with advanced or spreading clear cell kidney cancer. The therapy uses specially designed immune cells (CAR T cells) that target two markers on cancer cells to try to attack the tumor more safely. The study will…

This study tests a combination of chemotherapy (FLAG-Ida) plus two targeted drugs (venetoclax and asciminib) in 30 adults aged 18-70 with advanced chronic myeloid leukemia or a related acute leukemia. The first part checks safety, and the second part sees if the combo helps contr…

This study tests whether combining dasatinib with ropeginterferon can better control chronic myeloid leukemia in its early phase. About 40 adults newly diagnosed with CML will receive the drug pair to see if it improves disease control and reduces side effects. The goal is to man…

This early-phase trial tests a new treatment for people with certain blood cancers that have not responded to standard therapy. The treatment uses specially engineered natural killer (NK) cells from donated cord blood, designed to better target cancer cells and resist tumor defen…

This early-phase study tests a new treatment for people with widespread or multiple precancerous patches in the mouth. The treatment uses specially engineered immune cells (NK cells) from donated cord blood, designed to target and destroy abnormal cells. The main goal is to check…

This study tests a new treatment called CD70.CAR NK cells for people with diffuse large B-cell lymphoma or Hodgkin lymphoma that did not respond to or came back quickly after initial therapy. The treatment uses specially designed immune cells from a donor to find and attack cance…

This early-phase study tests a new treatment for a rare and serious condition where melanoma spreads to the lining of the brain or spinal cord. Up to 8 adults will receive their own specially trained immune cells injected directly into the spinal fluid. The main goal is to check …

This early-phase study tests a new drug called PLM-102 in 12 adults whose acute myeloid leukemia (AML) has come back or not responded to standard treatments. The main goals are to find the highest safe dose and to monitor side effects. Participants must have relapsed or refractor…

This early-phase study tests a combination of three drugs (avutometinib, defactinib, and everolimus) in people with recurrent endometrial cancer that has specific genetic changes in the RAS pathway. The main goal is to find a safe dose and understand side effects. About 31 partic…

This study tests whether the drug sacituzumab tirumotecan can control advanced or spreading SMARCB1-deficient renal medullary carcinoma, a rare and aggressive kidney cancer. It is for 20 people whose cancer has worsened after at least one prior treatment. The main goal is to chec…

This study tests whether a new combination of two drugs (blinatumomab given as a shot under the skin and olverembatinib taken by mouth) can help control a specific type of leukemia called Ph-positive ALL. The trial will enroll 60 adults with newly diagnosed or returning leukemia.…

This study tests a drug called mosunetuzumab in 30 adults with chronic lymphocytic leukemia (CLL) who still have traces of the disease after standard treatment. The drug is designed to help the immune system find and destroy remaining cancer cells. The goal is to see if it can sa…

This study looks at whether using the Provox ActiValve voice prosthesis as a first-choice device can lower the number of replacements needed each year in people who have had their voice box removed (total laryngectomy) and a tracheoesophageal puncture (TEP). About 48 adults who a…

This study tests a new combination of two drugs (BGB-16673 and sonrotoclax) in 40 people with untreated chronic lymphocytic leukemia (CLL). The goal is to see if this time-limited treatment can safely control the disease. Participants will receive the drugs for a set period, not …

This study tests a combination of three drugs (cemiplimab, fianlimab, and ipilimumab) given before surgery to people with advanced melanoma that can be removed. The goal is to see if the drugs are safe and help shrink tumors. About 20 adults with stage III or limited stage IV mel…

This early-stage trial tests a combination of two drugs, olutasidenib and ziftomenib, in adults with a certain type of acute myeloid leukemia (AML) that has not responded to treatment or has returned. The study has two parts: first, to find the safest dose, and second, to see if …

This study tests an oral chemotherapy drug, cladribine, combined with two other drugs (low-dose cytarabine and venetoclax) in people with acute myeloid leukemia (AML). The first part finds the safest dose; the second part checks if that dose helps control the disease. About 58 ad…

This study tests a new treatment for people with aggressive T-cell blood cancers, like certain leukemias and lymphomas. It uses specially engineered natural killer (NK) cells from donated cord blood, designed to target and destroy cancer cells. Participants will receive chemother…

This study tests whether combining three drugs (cladribine, ruxolitinib, and venetoclax) can control a rare, aggressive leukemia called T-PLL that has come back or not responded to prior treatment. The trial will enroll 36 adults and focus on safety and how well the drug combo wo…

This early-phase trial tests a virus called DNX-2401 that is designed to infect and destroy cancer cells in people with stage IV melanoma that has spread to the brain or other parts of the body. The main goal is to find the safest dose and number of injections. About 50 adults wi…

This study tests a drug called imetelstat in 30 adults with certain blood cancers (MDS/MPN). The goal is to see if it can help control the disease. The main focus is on safety and side effects. The study is not yet open for participants.

This pilot study tests whether the drug infliximab can safely reverse insulin dependence in people who developed diabetes after taking checkpoint inhibitor cancer therapy. About 14 participants will receive the drug and be monitored for side effects and changes in their need for …

This study tests a drug called zanzalintinib in 16 adults with recurrent or metastatic olfactory neuroblastoma, a rare cancer of the nasal cavity. The goal is to see if the drug can help control the disease and to check its safety. Participants must not have had similar drugs bef…

This early-phase study tests a combination of two drugs, izalontamab brengitecan and adagrasib, in 18 adults with advanced KRAS G12C-mutant non-small cell lung cancer that has not responded to other treatments. The main goal is to see if the combination is safe and works better t…

This early-phase study tests whether drug combinations tailored to each patient's tumor characteristics can help control metastatic colorectal cancer. About 100 adults with a specific type of colorectal cancer will receive personalized therapies. The main goal is to check safety …

This early-phase trial tests a new way to treat recurrent glioblastoma, an aggressive brain cancer. Doctors will deliver specially engineered natural killer (NK) cells directly into the brain tumor area. The NK cells are designed to better recognize and attack cancer cells while …

This early-phase study tests a combination of four drugs (pazopanib, trabectedin, ipilimumab, and nivolumab) in 18 children and young adults (ages 1-30) whose soft tissue sarcoma has come back. The main goal is to see if the treatment is safe and to find the best dose. This is no…

This study tests whether a drug called blinatumomab, given as a simple injection under the skin, can control small amounts of leftover leukemia cells (called measurable residual disease, or MRD) in adults with B-cell acute lymphoblastic leukemia. The goal is to prevent the cancer…

This early-phase study tests a new treatment for stomach cancer that has spread to the lining of the abdomen. Ten adults will receive specially engineered immune cells (NK cells) directly into the belly area. The goal is to find a safe dose and see if these cells can help control…

This early-phase trial tests a combination of four drugs (venetoclax, dexamethasone, bortezomib, and daratumumab) in 18 adolescents and young adults aged 12 to 30 whose T-cell acute lymphoblastic leukemia or lymphoma has returned or not responded to prior treatment. The main goal…

This study tests a combination of two drugs (AZA and APG1252) in 52 adults with high-risk acute myeloid leukemia (AML). The goal is to see if the combo is safe and can help control the disease. Participants include those whose cancer returned or didn't respond to prior treatment,…

This study aims to see if a contrast agent called gadopiclenol can improve MRI detection of leptomeningeal disease (LMD), a rare spread of cancer to the brain and spinal cord lining. About 40 adults with solid tumors who have unclear MRI results will receive the agent and be moni…

This study tests a special microscope that takes very clear, detailed pictures of cervical tissue samples right in the clinic. About 400 women aged 25 to 49 in Mozambique and Brazil who need a cervical biopsy or LEEP procedure will take part. The goal is to see if this microscope…

This study tests if drawing blood directly from veins inside the brain is a safe and effective way to diagnose high-grade glioma, a type of brain cancer. Twenty adults with suspected or confirmed glioma will participate. The goal is to see if this method can provide the same deta…

This study tests whether psilocybin, a natural psychedelic, can prevent or reduce nerve damage caused by chemotherapy in people with breast, colorectal, or head and neck cancer. About 83 participants will receive psilocybin, a placebo, or standard care before starting chemo. The …

This study tests a smartphone app designed to help women with inherited cancer gene mutations (like BRCA or Lynch syndrome) stick to recommended cancer screening schedules. The goal is to catch cancer early or prevent it. Researchers will enroll 80 women and track how safe and he…

This pilot study tests whether performing lymphatic reconstruction at the same time as lymph node removal surgery can prevent lymphedema (chronic swelling) in melanoma patients. Twenty adults undergoing lymph node removal for melanoma will receive the procedure and be monitored f…

This study looks at whether breathing in isopropyl alcohol (rubbing alcohol) can help lower nausea in people with cancer. About 112 patients who rate their nausea as at least 4 out of 10 will take part. The goal is to find a quick, drug-free way to ease nausea without using anti-…

This study tests if a program that delivers healthy food and teaches cooking skills is helpful for parents of children who have finished cancer treatment. The study will include 21 parents of children aged 5-12 who completed cancer therapy within the last five years. Researchers …

This study tests a virtual group lifestyle program for women with stable HR+/HER2- metastatic breast cancer. The goal is to see how much support helps them stick with healthy habits like diet and exercise. About 100 women will take part, and researchers will track safety and any …

This study tests a program called COPE (Creating Opportunities for Personal Empowerment) to see if it helps women with breast cancer feel more in control and supported during their first round of treatment. About 40 women will either receive the COPE program or standard care. The…

This study will give 50 women a Fitbit to wear before and after DIEP flap breast reconstruction surgery. The device tracks steps, heart rate, and sleep, and participants will answer short questionnaires about their recovery. The goal is to learn how patients recover so doctors ca…

This study looks at whether a special catheter called TriNav can give clearer CT images of liver tumors compared to standard catheters. The goal is to see if it helps doctors better plan a type of radiation treatment called Y90. About 20 adults with liver tumors that cannot be re…

This study will talk to 120 people in Texas who have breast, colorectal, lung, or prostate cancer. Researchers want to learn what makes it easier or harder to get cancer treatment on time. They will consider different types of insurance and cancer stages. The goal is to find ways…

This study looks at how cancer patients view their doctor's compassion, communication, and professionalism when the doctor uses an electronic health record (EHR) during the visit. About 88 adults with cancer will watch videos or fill out questionnaires. The goal is to understand …

This study focuses on increasing the number of minority patients in prostate cancer clinical trials. Researchers will test ways to remove barriers for patients, doctors, and the hospital system. About 60 prostate cancer patients at Lyndon B. Johnson Hospital will take part. The g…

This study talks to 20 pancreatic cancer patients to learn why people from different backgrounds, incomes, or locations may not join clinical trials as often. Researchers hope to find better ways to inform and support all patients so that future research is fair and helpful for e…

This study looks at whether intermittent fasting (a pattern of eating only during certain hours) is safe and doable for 20 people at high risk for pancreatic cancer. Researchers will also check if fasting changes certain body markers linked to metabolism, inflammation, and gut he…

This study looks at whether making an audio recording of your clinic visit helps you remember what the doctor said and share it with family or caregivers who weren't there. About 200 adults with advanced cancer at MD Anderson will be asked to record their visit and later report i…

This study aims to understand how migration history and social factors affect the quality of life of Black immigrant men from Sub-Saharan Africa and the Caribbean who have been diagnosed with prostate cancer. Researchers will interview 40 men to learn about their experiences and …

This study looks at whether blood tests and imaging scans can show if early-stage triple-negative breast cancer has fully responded to chemotherapy before surgery. About 200 people will receive standard chemo plus immunotherapy, and researchers will check if these tests can accur…

This study looks at how cancer care is provided in oncology and supportive care clinics. Researchers will collect feedback from 200 adults with advanced solid tumors to better understand and improve care delivery. The goal is to help doctors learn from patient experiences, not to…

This study tests a program that helps people with certain genetic mutations (like BRCA) talk to their relatives about genetic testing and make informed choices. About 2,100 participants will either get standard care or the program plus free genetic counseling. The goal is to see …

This early-phase study looks at how the drug cabozantinib changes the immune environment in bone for people with kidney cancer that has spread to the bone. Researchers want to understand these changes to prevent bone problems and improve treatment. The study will enroll 16 partic…

This early-stage study tests whether a magnetic tracer and a fluorescent dye can safely help doctors find lymph nodes where stomach cancer may have spread. About 20 adults with early stomach cancer will receive the injection before surgery. The goal is to see if this method is sa…

This study looks at what helps or hinders prostate cancer patients from completing genetic testing. Researchers will develop and test a decision support tool to educate patients and help them decide about testing. The goal is to increase testing rates, which can guide treatment a…

This study looks at why some people have ongoing loose stools after surgery for colon cancer. Researchers will use a new device to check for bile acid problems and bacterial overgrowth in the small intestine. The goal is to better understand these symptoms and how they affect qua…

This study will collect medical data and samples from 300 cancer patients who have a serious fungal infection called mucormycosis, or are at risk for it. The goal is to learn more about the disease and find better ways to diagnose and treat it. Participants will undergo standard …

This study looks at the stress and unmet needs of people caring for someone with gynecologic cancer. It will follow 250 patients and their caregivers for 6 months to see how caregiver distress affects both the caregiver and the patient. The goal is to find better ways to support …