M.d. Anderson Cancer Center

This study looks at whether the Gardasil 9 vaccine can help prevent HPV infection in people who have had a stem cell transplant for blood cancer. About 48 adults will receive the vaccine as part of their usual post-transplant care. Researchers will measure antibody levels to see …

This study looks at whether a pneumonia vaccine (PCV20) works better as a single shot or a boosted series in 30 adults who have recovered from B-cell lymphoma and previously received anti-CD20 therapy. The goal is to see which approach is safer and more effective at preventing pn…

This study aimed to find a safe dose of a custom-made mRNA vaccine for people with a rare skin cancer called cutaneous angiosarcoma. The vaccine was designed to train the immune system to fight the cancer. However, the trial was withdrawn before any participants were enrolled, so…

This study tests whether giving two drugs (acalabrutinib and obinutuzumab) in cycles, rather than continuously, can keep chronic lymphocytic leukemia (CLL) under control. About 60 adults with untreated CLL who need therapy will receive the combination. The goal is to see if patie…

This study tests a combination of three drugs (cetuximab, LY3214996, and abemaciclib) in people with advanced colorectal cancer that has spread and no longer responds to standard therapy. The goal is to see if the combination can shrink tumors and improve survival. About 46 adult…

This study tests whether giving radiation therapy before surgery can shrink tumors in people with hormone receptor-positive, HER2-negative breast cancer. The goal is to make the tumor smaller so less healthy tissue needs to be removed during surgery. About 25 adults with residual…

This study tested a combination of three chemotherapy drugs (docetaxel, cisplatin, and fluorouracil) in 31 people with advanced nasal cavity or sinus cancer that had not been treated before. The goal was to see if this treatment could shrink tumors and keep the cancer from coming…

This study tests whether using heat (thermal ablation) followed by precise radiation (stereotactic radiosurgery) can better control cancer that has spread to the spine and is pressing on the spinal cord. About 60 adults with various solid tumors and moderate to severe spinal cord…

This study looks at whether using focused radiation (stereotactic radiosurgery) only on the brain tumors, instead of the whole brain, can help preserve thinking and memory in people with small cell lung cancer that has spread to the brain. About 55 participants will receive this …

This study tests whether giving immunotherapy drugs (nivolumab with or without ipilimumab) and radiation before surgery can help shrink tumors in people with two rare types of sarcoma. About 32 adults with these sarcomas that can be surgically removed will receive the treatment a…

This early-phase study tests whether giving immunotherapy drugs (nivolumab alone or with bevacizumab or ipilimumab) before surgery is safe for people with advanced kidney cancer that has spread. About 104 participants will receive one of these treatments before their tumor is rem…

This study tests a treatment called LN-145, which uses a patient's own immune cells taken from their tumor. The cells are grown in a lab and then given back to the patient to help kill cancer cells. The study includes adults with ovarian cancer, triple-negative breast cancer, ana…

This study tests a combination of two chemotherapy drugs (CPX-351 and gemtuzumab ozogamicin) in about 50 adults with acute myeloid leukemia (AML) that has returned or not responded to treatment, or with high-risk myelodysplastic syndrome (MDS). The goal is to see if the combo is …

This early-phase study tests a new drug called tegavivint, combined with decitabine, in adults with leukemia that has come back or not responded to standard treatments. The goal is to find the safest dose and see if the combination can help control the disease. Only 9 participant…

This early-stage trial tests a new treatment called IVS-3001, which uses a patient's own immune cells (T cells) engineered to recognize and attack a protein called HLA-G found on certain solid tumors. The study includes 31 adults with advanced cancers that have not responded to s…

This study tests whether a combination of two chemotherapy drugs, azacitidine and venetoclax, can help keep acute myeloid leukemia (AML) in remission and prevent it from returning. About 50 adults whose AML is in remission after initial treatment and who are not ready for a stem …

This study tests a new radiation approach for women with early-stage breast cancer. Instead of treating the whole breast, it targets only the area where the cancer was removed, using higher daily doses over a shorter time. The goal is to see if this method causes fewer side effec…

This study tests whether the drug bevacizumab (Avastin) can help control ovarian, fallopian tube, or primary peritoneal cancer that is still present after initial treatment and found during a second-look surgery. The trial enrolled 35 adults with advanced-stage cancer who had alr…

This study compares proton beam therapy (a newer, more targeted radiation) to standard intensity-modulated radiation therapy (IMRT) for people with esophageal cancer. Both are given along with chemotherapy. The goal is to see if proton therapy can control the cancer just as well …

This study tests a combination of targeted drugs (ibrutinib, rituximab, venetoclax) plus chemotherapy in 51 young patients newly diagnosed with mantle cell lymphoma. The goal is to see how well the treatment shrinks or eliminates cancer. Participants receive the drugs in a specif…

This study tested whether a combination of three drugs—everolimus, letrozole, and metformin—can help control advanced or recurrent endometrial cancer. The 62 participants had cancer that came back or spread and had limited prior treatments. The goal was to see how many patients h…

This study tests a drug called adavosertib, given alone or with olaparib, in women with ovarian, fallopian tube, or peritoneal cancer that has returned and stopped responding to PARP inhibitors. The goal is to see if these drugs can shrink tumors or stop them from growing. About …

This study tests whether giving two drugs—sacituzumab govitecan and pembrolizumab—before surgery can help control early-stage triple-negative breast cancer that did not respond well to initial chemotherapy and immunotherapy. About 27 adults with this specific type of breast cance…

This study compares radiation therapy alone versus radiation plus rituximab (a drug that helps the immune system attack cancer) for patients with early-stage (I or II) low-grade follicular lymphoma. The goal is to see if the combination keeps the cancer from progressing longer. A…

This study tests a personalized approach to radiation therapy for liver cancer patients whose tumors cannot be removed by surgery. By customizing the radiation dose for each person, researchers hope to improve tumor shrinkage while protecting healthy liver tissue. The trial invol…

This early-phase trial tests several new drug combinations in people with advanced solid tumors (like stomach, ovarian, or liver cancer) that have spread and stopped responding to standard treatments. The goal is to find the safest dose and see if the drugs can help control the c…

This early-phase study tested two immunotherapy drugs (durvalumab and tremelimumab) given before surgery to people with a serious type of bladder cancer that cannot be treated with standard chemotherapy. The main goal was to check safety and side effects. Researchers also looked …

This study looks at whether patient navigators (health coaches) can help more obese adults sign up for and attend weight management programs. About 171 participants will be assigned to either get navigator support or standard care. The goal is to see if this approach increases pr…

This study tests a type of radiation called hypofractionated proton beam therapy for men with early-stage prostate cancer that hasn't spread. The goal is to see if giving higher doses of radiation in fewer sessions can kill cancer cells while causing less damage to healthy tissue…

This study tests a combination of two chemotherapy drugs and two immunotherapy drugs given before surgery to people with pancreatic cancer that can be removed. The goal is to shrink the tumor and help the immune system fight the cancer, potentially improving outcomes. The trial i…

This early-phase study tests whether combining two drugs, amivantamab and tepotinib, can help control non-small cell lung cancer that has changes in the MET gene. The study includes about 3 adults with advanced lung cancer that cannot be removed by surgery. Researchers will monit…

This early-phase study tests whether giving patients with advanced melanoma their own genetically modified T-cells, followed by high-dose interleukin-2, is safe and feasible. The T-cells are altered in the lab to resist a protein that normally stops them from attacking tumors. Ab…

This study looks at what happens after surgery to remove kidney cancer that has spread to other parts of the body. About 86 people with kidney cancer will have the tumors removed, and then doctors will follow them to see how long they stay cancer-free. The goal is to learn if thi…

This early-phase study tests a new drug called Q702 combined with two standard chemotherapy drugs (azacitidine and venetoclax) in 17 adults whose acute myeloid leukemia has returned or not responded to prior treatments. The main goal is to check the safety and side effects of thi…

This study tests whether a pulmonary rehabilitation program can improve lung function in people with lung cancer who are not healthy enough for surgery. The goal is to help more patients become eligible for lung resection. Researchers will also check how participants recover afte…

This study looks at whether adding chemotherapy to surgery helps people with colorectal cancer that has spread only to their lungs. About 40 participants will be grouped by risk level and receive either surgery alone, chemotherapy alone, or both. The goal is to see which approach…

This study tests whether adding the immunotherapy drug durvalumab to standard chemotherapy helps people with bladder cancer that has spread to nearby lymph nodes. About 60 participants will receive either chemo alone or chemo plus durvalumab, followed by maintenance durvalumab fo…

This study tests whether combining two drugs, atezolizumab and bevacizumab, can shrink or slow the growth of rare solid tumors. About 133 adults with cancers like Merkel cell, nasopharyngeal, or mesothelioma will receive the treatment. The goal is to control the disease, not cure…

This early-phase study tests a DNA vaccine made from patients' own cancer cells to help their immune system attack lymphoplasmacytic lymphoma, a rare blood cancer. Nine participants with asymptomatic disease will receive the vaccine to find the safest dose and see if it boosts ca…

This study tests a treatment that uses a patient's own immune cells (T-cells) to fight advanced melanoma. Some patients also receive a dendritic cell vaccine to boost the immune response. The goal is to see if the combination helps T-cells last longer and shrink tumors better tha…

This study tests if tranexamic acid, a drug that helps blood clots stay stable, can reduce bleeding in patients having hemipelvectomy surgery for pelvic tumors. About 80 adults and children with pelvic tumors will take part. The goal is to see if the drug lowers the amount of blo…

This early-phase study tests a drug called palbociclib, given alone or with other medicines, in people whose leukemia has returned or stopped responding to standard treatments. The main goal is to find the safest dose and understand side effects. About 32 adults with acute myeloi…

This early-phase trial tests a new drug that targets a specific gene (EphA2) to slow tumor growth in people with advanced solid tumors that have spread or returned. The study involves 49 participants and focuses on finding the safest dose and understanding side effects. Researche…

This study tests a combination of targeted therapy (ibrutinib) and immunotherapy (rituximab) followed by strong chemotherapy in young patients with newly diagnosed mantle cell lymphoma, an aggressive blood cancer. The goal is to see if this approach improves response rates while …

This study tested whether a combination of two drugs, letrozole and everolimus, can help control advanced or recurrent endometrial cancer. 42 participants whose cancer had returned or worsened despite prior treatment were enrolled. The goal was to see if the tumors shrank or stop…

This study tested a combination of four chemotherapy drugs (5-FU, leucovorin, gemcitabine, and cisplatin) in 46 patients with advanced bladder cancer that had spread or could not be removed by surgery. The goal was to see how many patients' tumors shrank or disappeared. The treat…

This study tests whether the drugs bortezomib and rituximab can help control Waldenstrom's macroglobulinemia, a rare blood cancer. About 46 people who have not had prior treatment will receive the combination. The goal is to shrink the cancer and collect stem cells that could be …

This early-stage trial tests a new drug (DS3201) combined with an immunotherapy (ipilimumab) in adults with advanced prostate, bladder, or kidney cancer that has spread. The goal is to find the safest dose and see if the combination can help control the disease. About 65 particip…

This study tests whether adding evolocumab to the immunotherapy drug nivolumab can help control metastatic renal cell carcinoma that has not responded to prior treatments. Ten adults with clear-cell kidney cancer will receive the combination, and researchers will monitor safety a…

This study is testing a combination of two drugs, selumetinib and olaparib, in people with advanced or recurrent solid tumors (including breast, digestive, female/male genital, and thyroid cancers). The first part finds the safest dose, and the second part checks if that dose hel…

This study tests whether two immunotherapy drugs, oleclumab and durvalumab, can help people with sarcoma that has spread or come back. About 75 adults and teens with certain sarcoma types will receive these drugs to see if tumors shrink or stop growing. The goal is to find a new …

This study tests two drug combinations (olaparib plus either vistusertib or capivasertib) in people with recurrent endometrial, triple-negative breast, ovarian, or related cancers. The goal is to find the safest dose and see if the drugs can control tumor growth. About 159 partic…

This study tests whether adding targeted radiation to standard drug therapy can better control cancer that has spread to 1 to 5 spots in the body. About 380 adults with solid tumors will be randomly assigned to receive either standard therapy alone or standard therapy plus radiat…

This early-phase study tests the safety and best dose of two drugs, ceritinib and everolimus, given together to adults with advanced solid tumors or a specific type of lung cancer (ALK-positive NSCLC). The goal is to find the highest safe dose and see if the combination can shrin…

This study tests whether adding rituximab to ibrutinib helps people with chronic lymphocytic leukemia (CLL) that has returned after previous treatment. About 66 adults will receive either ibrutinib alone or ibrutinib plus rituximab. The goal is to see which approach keeps the can…

This early-phase study tested a new drug called UGN-201 in 10 people with bladder cancer who were scheduled to have their bladder removed. The main goal was to check the drug's safety and see if it caused any serious side effects or surgery delays. Researchers also looked for sig…

This study tests whether combining an immunotherapy drug (nivolumab) with two targeted drugs (either dabrafenib + trametinib or encorafenib + binimetinib) can shrink or control advanced melanoma that has spread to the brain or other organs. About 52 adults with a specific gene mu…

This study compares two FDA-approved drugs, cabozantinib and sunitinib, in people with a rare type of advanced kidney cancer called variant histology renal cell carcinoma. The goal is to see which drug is safer and more effective at slowing cancer growth. About 32 to 84 participa…

This study tests two drugs, venetoclax and acalabrutinib, given together to people with mantle cell lymphoma that came back or didn't respond to prior therapy. The goal is to see if the combination can shrink or eliminate cancer. About 32 adults will take part, and the main focus…

This early trial tests combining the targeted drug brigatinib with local treatments like surgery or radiation for people with advanced ALK-positive non-small cell lung cancer. The goal is to see if this approach is safe and helps control the cancer longer. About 35 participants w…

This study tests whether adding the immunotherapy drug pembrolizumab to standard hormone therapy can help prevent recurrence in people with a rare, aggressive type of breast cancer called inflammatory breast cancer. Participants had hormone receptor-positive cancer that did not f…

This study tested whether adding the targeted drug Tarceva to two standard chemotherapy drugs (cisplatin and docetaxel) could shrink tumors in people with head and neck cancer that had spread or come back. 50 adults with this advanced cancer took part. The goal was to see how wel…

This early-phase trial studies the safety and effectiveness of combining two immunotherapy drugs (ipilimumab and nivolumab) with radiation therapy for patients with stage II or III non-small cell lung cancer that cannot be removed by surgery. The goal is to see if this combinatio…

This study tests whether combining two immunotherapy drugs (nivolumab and ipilimumab) with or without a chemotherapy drug (azacitidine) can help people with myelodysplastic syndromes (MDS), a type of bone marrow cancer. About 99 adults with MDS who either haven't been treated or …

This early-phase study tests a drug called neratinib combined with one of three other drugs (everolimus, palbociclib, or trametinib) in people with advanced solid tumors that have not responded to standard treatments. The study focuses on tumors with specific gene changes (EGFR, …

This study tests whether using MRI scans to guide the placement of internal radiation (brachytherapy) can improve treatment for women with advanced HPV-related cervical or vaginal cancers. The approach aims to deliver a more precise dose to the tumor while sparing nearby organs. …

This study tests whether giving a higher radiation dose directly to the tumor, while keeping the standard dose to surrounding healthy tissue, can improve outcomes for people with stage II to IIIB non-small cell lung cancer. About 146 participants will receive either photon (IMRT)…

This study tests two drugs, panitumumab and trametinib, in people with stage IV colorectal cancer that no longer responds to standard treatments. The goal is to see if these drugs can shrink tumors or slow cancer growth. About 59 participants will receive either panitumumab alone…

This study tests whether a very low dose of radiation (4 Gy) can control slow-growing B-cell lymphoma in the eye socket. About 50 adults with stage I-IV indolent lymphoma or mantle cell lymphoma will receive this targeted treatment. The goal is to shrink or stop the cancer while …

This study was designed to test whether adding olutasidenib to standard chemotherapy (hypomethylating agents) could help control certain blood cancers with an IDH1 mutation, including myelodysplastic syndromes, chronic myelomonocytic leukemia, and advanced myeloproliferative neop…

This early-stage trial tests whether adding the immunotherapy drug pembrolizumab to standard chemoradiotherapy can help control advanced gastroesophageal cancer that cannot be surgically removed. The study enrolled 16 participants and aims to see if the combination can make the c…

This study tested whether proton beam therapy, sometimes combined with standard radiation, can control skull base chordoma—a rare tumor near the brain. Nineteen participants who had surgery received this precise radiation to try to prevent the tumor from coming back. Researchers …

This study tests a drug called cetuximab in 29 adults with advanced or metastatic chordoma, a rare bone cancer. The goal is to see if the drug can shrink tumors or slow the disease. Participants receive cetuximab and are monitored for side effects and tumor response.

This study tests whether a hormone-releasing IUD (Mirena) alone or combined with the drug everolimus can control or reverse early-stage endometrial cancer or its precancerous condition. About 102 women with complex atypical hyperplasia or low-grade endometrial cancer will receive…

This study tests a powerful mix of chemotherapy drugs plus a targeted pill (ponatinib) for people with a fast-growing leukemia called Philadelphia chromosome-positive ALL. The goal is to see if this combination can stop the cancer from coming back. About 88 adults with newly diag…

This study tests a combination of three drugs (acalabrutinib, lenalidomide, and rituximab) in 60 people with untreated stage III-IV follicular lymphoma. The goal is to see if the combo can shrink or eliminate tumors and keep the cancer under control. Participants must have measur…

This study tests whether adding special immune cells called veto cells can help donor stem cells grow safely after a transplant for blood cancers. The goal is to prevent graft-versus-host disease, where donor cells attack the patient's body. About 16 people aged 12 to 75 with var…

This study tests whether focused, high-dose radiation (SBRT) can control kidney cancer that has spread to a few spots in the body. The goal is to see if radiation alone can delay or avoid the need for strong drugs (systemic therapy). About 123 people with metastatic kidney cancer…

This study aimed to see if the drug TTI-101 could slow tumor growth in people with HPV-negative head and neck cancer before they had surgery. It was designed for patients with stage II to IV cancer that could be removed. However, the trial was withdrawn before enrolling any parti…

This study tests whether two drugs, fulvestrant and abemaciclib, can help control low-grade serous ovarian cancer in women with advanced disease. Up to 18 participants will receive the drugs before surgery to see if the cancer shrinks or stabilizes. The goal is to improve treatme…

This early study tests whether elotuzumab can help people with a specific type of myelofibrosis, a serious bone marrow disorder. The drug targets a protein on cancer cells to try to improve blood counts, shrink an enlarged spleen, and ease symptoms. The trial includes 15 adults w…

This study looks at whether a Mediterranean diet is safe and doable for 25 Hispanic or Black men with prostate cancer who get care at LBJ Hospital in Houston. The goal is to see if this diet can help manage the disease. Participants will follow the diet and be checked for side ef…

This study tests a new drug, SX-682, alone and with the immunotherapy nivolumab, in people with a specific type of advanced colorectal cancer that has spread or cannot be removed. The cancer must have a RAS mutation and be microsatellite stable (MSS), which often makes it harder …

This early-phase study tests a new treatment called OBX-115, which uses a patient's own tumor-fighting immune cells that have been modified to include a protein (IL15) to help them survive longer. These cells are given along with a drug called acetazolamide to adults with advance…

This study tests whether combining two drugs—obinutuzumab and CC-99282—can control follicular lymphoma in people with a high tumor burden who have not received treatment before. About 33 adults with stage II–IV disease will take part. The goal is to see if the combination is safe…

This study tests a drug called acalabrutinib in people with mantle cell lymphoma who had to stop taking ibrutinib because of bad side effects. The goal is to see if acalabrutinib can shrink or control the cancer without causing the same problems. Nine participants are enrolled, a…

This study tests whether giving the drug sunitinib before surgery can help control metastatic renal cell carcinoma (kidney cancer that has spread). About 50 participants with advanced kidney cancer who are eligible for surgery will receive sunitinib before their operation. Resear…

This study was designed to test a radioactive drug (177Lu-PSMA-617) in men with advanced prostate cancer that has spread to the bone marrow and caused low blood cell counts. The goal was to see if the treatment was safe and how it affected the cancer. However, the study was withd…

This study tests a combination of three drugs (atezolizumab, obinutuzumab, and venetoclax) in about 50 adults with chronic lymphocytic leukemia, small lymphocytic lymphoma, or Richter syndrome that has come back or not responded to prior treatment. The goal is to see if the combi…

This study tests whether a combination of four drugs (BMS-986340, nivolumab, trifluridine/tipiracil, and bevacizumab) can help control advanced colorectal cancer that has stopped responding to standard treatments. The trial includes 7 adults with a specific type of cancer called …

This study tested a combination of two chemotherapy drugs (cisplatin and docetaxel) plus an immunotherapy drug (pembrolizumab) in 28 patients with stage II or III laryngeal cancer. The goal was to see if this drug-only approach could control the cancer and avoid the need for surg…

This study looks at whether adding surgery or radiation to the targeted drug osimertinib helps people with advanced EGFR-mutant non-small cell lung cancer live longer without their cancer growing. About 173 participants will receive either osimertinib alone or osimertinib plus lo…

This study compares two treatments for lung tumors: microwave ablation (using heat to kill cancer cells) and surgical wedge resection (removing a small piece of lung). It includes adults with non-small cell lung cancer, sarcoma, or colorectal cancer that has spread to the lungs. …

This study tests a specific timing of chemotherapy drugs (busulfan and fludarabine) before a donor stem cell transplant, followed by cyclophosphamide after the transplant, to treat high-risk blood cancers like leukemia and lymphoma. The goal is to reduce the chance of the transpl…

This study tests whether adding elotuzumab to the standard maintenance drug lenalidomide can help prevent multiple myeloma from returning after a stem cell transplant. About 113 adults who recently had a transplant using their own stem cells will receive this combination therapy.…

This early-phase study tests whether combining two immunotherapy drugs, atezolizumab and tiragolumab, can help control cancers where the original tumor site is unknown. Four adults whose cancer has not responded to standard chemotherapy will receive the drug combination. The main…

This study looks at whether a very low dose of radiation, given before or after drug therapy, can help control mantle cell lymphoma that has returned or stopped responding to treatment. About 51 adults with this type of cancer will receive ultra low dose radiation, which aims to …

This study tests whether adding itacitinib to standard care can prevent graft-versus-host disease (GVHD) in people who receive a donor stem cell transplant for blood disorders. GVHD happens when donor cells attack the patient's body. The trial involves 31 adults aged 18 to 70 and…

This study tests whether adding ribociclib to the standard combination of everolimus and letrozole can better control advanced or recurrent endometrial cancer. About 90 participants will receive either two or three drugs to see which approach improves tumor shrinkage or stability…

This study tests a drug called XmAb20717 in 140 people with advanced rare cancers, such as certain mesotheliomas, lymphomas, and lung cancers. The goal is to see if the drug can shrink tumors and how safe it is. The trial is currently on hold.

This study looks at whether a focused, one-time radiation treatment called stereotactic radiosurgery (SRS) can control melanoma tumors that have spread to more than three spots in the brain while also protecting memory and thinking skills. About 49 adults with advanced melanoma a…

This study tests a combination of four drugs (ibrutinib, fludarabine, cyclophosphamide, and obinutuzumab) as the first treatment for people with chronic lymphocytic leukemia (CLL) who have a specific genetic marker (mutated IGHV gene). The goal is to see if this combo can achieve…

This early-phase trial tests a new approach for people with advanced bile duct cancer that has spread. It combines a special type of radiation (given in fewer, stronger doses) with an immunotherapy drug called bintrafusp alfa, which helps the immune system fight cancer. The goal …

This early-phase study tests whether a single, powerful dose of radiation aimed at the spine can safely treat cancer that has spread to the backbone and is pressing on the spinal cord. The treatment is for people who cannot have surgery and have not had radiation to that area bef…

This study tests whether combining three drugs—ciforadenant, ipilimumab, and nivolumab—can help control advanced kidney cancer that has spread. About 50 adults with stage IV clear cell renal cell carcinoma who have not had prior treatment will receive this combination. The main g…

This study tests a combination of two drugs, venetoclax and decitabine, in 20 adults with acute myeloid leukemia that has returned or not responded to prior treatment. The goal is to see if the combination can shrink or control the cancer. Participants will take the drugs by mout…

This study tests whether using MRI scans to plan radiation doses can control HPV-positive throat cancer as well as standard treatment, while reducing severe swallowing side effects. About 90 adults with early-stage cancer will receive radiation doses adjusted based on MRI images.…

This early-phase study aims to find the highest safe dose of a chemotherapy combination (gemcitabine and doxorubicin) when given with the targeted drug bortezomib. It includes up to 80 adults with advanced urothelial cancer or other solid tumors that cannot be removed by surgery.…

This study tests a combination of two drugs, ibrutinib and rituximab, in people with mantle cell lymphoma that has returned or not responded to treatment, as well as in older patients newly diagnosed with the disease. The goal is to see how well the drugs work together to shrink …

This study tests whether adding local treatments like surgery or radiation to immunotherapy (nivolumab and ipilimumab) helps people with stage IV non-small cell lung cancer live longer. About 339 participants will receive immunotherapy alone or with local therapy. The goal is to …

This study compares two types of radiation therapy for people with stage III-IVB oropharyngeal (throat) cancer. One uses protons (IMPT) and the other uses standard X-rays (IMRT). The goal is to see if proton therapy causes fewer severe side effects while still controlling the can…

This early-phase study tests a chemotherapy drug called paclitaxel, given directly into the abdomen, for people with advanced stomach cancer that has spread to the lining of the belly. The main goal is to find the safest dose and understand side effects. About 27 adults with this…

This study tests a combination of three drugs (pirtobrutinib, rituximab, and venetoclax) in 50 adults with untreated mantle cell lymphoma. The goal is to see how many patients achieve a complete response (cancer disappearance) after the therapy. Researchers will also monitor side…

This study tested the drug pembrolizumab in 71 people with advanced inflammatory or triple-negative breast cancer that had spread or returned. Participants had already responded to chemotherapy. The goal was to see if pembrolizumab could keep the cancer from growing for at least …

This study tests two drugs, regorafenib and lorigerlimab, in people with high-risk colorectal cancer who have tiny amounts of cancer DNA in their blood after finishing standard treatments. The goal is to see if this combination can safely clear those leftover cancer cells. The tr…

This study tests the drug vemurafenib in 24 people with advanced papillary thyroid cancer that has spread or cannot be easily removed. The drug blocks a specific gene mutation (BRAF) that fuels cancer growth. Researchers measure how much tumors shrink and how biomarkers change af…

This early-phase trial tested the drug pembrolizumab in 20 people with smoldering multiple myeloma, a slow-growing blood cancer at risk of becoming active. The goal was to see if the drug could shrink or control the cancer and delay progression. Participants received treatment fo…

This study tests a two-step treatment for men with an aggressive form of prostate cancer that has spread. First, patients receive chemotherapy plus an immunotherapy drug. Then, they take a maintenance drug (niraparib) either alone or with more immunotherapy. The goal is to see if…

This early-stage study tests the safety and best dose of a three-drug combination (daratumumab, ixazomib, and dexamethasone) for people with AL amyloidosis, a rare disease where abnormal proteins build up in organs. The trial includes 21 participants with newly diagnosed or retur…

This study tests whether a precise type of radiation called stereotactic radiosurgery, given after surgery to remove brain tumors, can prevent the tumors from coming back. About 132 patients with up to 3 brain metastases will be randomly assigned to receive either the radiation o…

This study is for people with advanced non-small cell lung cancer that has spread to the brain. It tests whether adding immunotherapy drugs (nivolumab with or without ipilimumab) to radiation therapy can better control the cancer. The goal is to find the safest and most effective…

This study tests a combination of two drugs, venetoclax and ASTX727, in people with high-risk myelodysplastic syndrome (MDS) or chronic myelomonocytic leukemia (CMML) who haven't had treatment yet. The goal is to find the best dose and see how well the drugs control the cancer by…

This early-phase study tests whether combining two drugs, DKN-01 and pembrolizumab, can help control advanced or recurrent endometrial cancer that cannot be cured with surgery or radiation. Eight adult women with this type of cancer will receive the combination. The main goals ar…

This study tests a combination of two drugs, pemetrexed and avelumab, in people with a specific type of advanced bladder cancer that lacks a protein called MTAP. The goal is to see if this treatment can shrink or control the cancer. About 18 participants who have already tried ch…

This study tests whether taking selpercatinib before surgery can shrink thyroid tumors that have a specific genetic change (RET alteration). About 30 people with advanced or recurrent thyroid cancer will receive the drug before their operation. The goal is to make surgery more ef…

This study compares two medications, infliximab and vedolizumab, to treat colon inflammation (colitis) caused by immune checkpoint inhibitor therapy in cancer patients. About 47 adults with genitourinary cancer, melanoma, or non-small cell lung cancer are participating. The goal …

This study looks at whether adding Juice Plus+ and Juice Plus+ Complete supplements to the diet can improve health markers in ovarian cancer patients who are in remission. About 75 participants will either take the supplements or receive dietary counseling alone. Researchers will…

This study was designed to test a new combination of two drugs (ASTX727 and ASTX029) for people with certain types of blood cancers (MDS or MDS/MPN) that have a specific gene mutation (RAS). The goal was to find a safe dose and see if the combination could control the disease. Ho…

This study tested a combination of two targeted drugs, venetoclax and ibrutinib, in 234 people with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). Some participants had already tried other treatments, while others had high-risk features and had not been t…

This study tests whether the drug isatuximab, given alone or with lenalidomide, can control high risk smoldering multiple myeloma and delay progression to active disease. About 61 participants will receive treatment and be monitored for response and side effects. The goal is to f…

This study compares two chemotherapy drug combinations in 128 people with advanced head and neck cancer that hasn't been treated yet. The goal is to find out which combination helps patients live longer without the cancer growing back. Researchers will also track side effects to …

This study tests whether adding immunotherapy drugs (atezolizumab and tiragolumab) to standard chemotherapy before surgery can better control esophageal or gastroesophageal cancer. About 43 adults with stage II or III cancer will receive the drug combination, then undergo surgery…

This early-phase trial tests whether giving targeted drugs based on a patient's specific genetic mutations can prevent acute myeloid leukemia (AML) from coming back. It enrolls people with AML who have signs of returning disease. The main goal is to check safety and side effects.

This study was designed to see if the drug glofitamab can stop large B-cell lymphoma from returning in patients who are in complete remission but still have tiny traces of the disease (called minimal residual disease). The trial planned to enroll adults who completed standard che…

This study tests a new way to treat adults with a specific type of leukemia (Ph+ ALL) that has come back or not responded to treatment. The approach combines low-intensity chemotherapy with two targeted drugs, ponatinib and blinatumomab, to kill cancer cells and boost the immune …

This early-phase study tests whether combining two drugs—sarilumab (Kevzara) and cemiplimab—can safely control non-small cell lung cancer with specific gene changes (EGFR or LKB1/STK11 mutations). About 56 adults with advanced disease will receive the combination. The main goal i…

This study tests the safety of adding an experimental drug (MPDL3280A) to standard chemotherapy and radiation for people with non-small cell lung cancer that cannot be removed by surgery. About 52 participants will receive the combination therapy at MD Anderson Cancer Center. The…

This study tests a mix of drugs (olaparib, durvalumab, carboplatin, etoposide) plus radiation in people with advanced small cell lung cancer that has spread. The goal is to see if this combination is safe and works better than standard treatment. About 63 participants will take p…

This study tests whether adding tocilizumab to standard immunotherapy (ipilimumab and nivolumab) can reduce severe side effects in people with advanced melanoma, lung cancer, or bladder cancer. About 35 participants will receive the combination to see if it is safer and still eff…

This study tests whether adding a special type of talk therapy (CBASP) to standard smoking cessation treatment helps depressed smokers quit and stay smoke-free. About 91 adults with depression who smoke at least 5 cigarettes daily will be randomly assigned to either the CBASP com…

This study tests two drug combinations for people with inflammatory breast cancer that has come back or spread. One group gets three drugs (atezolizumab, cobimetinib, and eribulin) and the other gets two (atezolizumab and eribulin). The goal is to see how well these treatments sh…

This early-phase trial tests a combination of three drugs (dasatinib, temsirolimus, and cyclophosphamide) in children and young adults with advanced solid tumors that have come back or not responded to standard treatments. The main goals are to find the safest dose and understand…

This study tested a combination of three drugs (sorafenib, carboplatin, and paclitaxel) in 48 adults with head and neck squamous cell cancer that had spread or returned. The goal was to see how well the treatment shrank tumors and delayed cancer growth. Participants received the …

This study tests a combination of two drugs—pembrolizumab (an immunotherapy) and romidepsin (a targeted therapy)—in people with a rare type of blood cancer called peripheral T-cell lymphoma that has returned or not responded to prior treatment. The goal is to see if the combo is …

This study tests whether a shorter, higher-dose radiation schedule (hypofractionated) works as well as the standard longer course for men with prostate cancer who have had their prostate removed. About 186 men will be randomly assigned to one of the two radiation plans. The main …

This early-phase study tests a new drug combination for people with advanced ALK-positive non-small cell lung cancer. The goal is to find the best dose of ensartinib when given with standard chemotherapy and a targeted antibody. About 12 participants will receive the treatment to…

This study tests whether adding the immunotherapy drug atezolizumab to standard chemotherapy can help people with advanced anaplastic or poorly differentiated thyroid cancer live longer. About 50 participants will receive different drug combinations based on their cancer's geneti…

This study tests two drugs together—trametinib and pembrolizumab—in people with advanced non-small cell lung cancer that has returned or spread. The goal is to see if the combination can shrink tumors or slow the cancer's growth. About 37 participants will receive the treatment, …

This early-phase study tests a drug called NBTXR3, which is activated by radiation, in people with pancreatic cancer that is locally advanced or borderline resectable. The goal is to find a safe dose and see if it helps control the disease. About 24 adults will receive the drug i…

This study tests whether the drug olaparib can help control aggressive variant prostate cancer when given after initial chemotherapy. About 96 men will receive cabazitaxel, carboplatin, and prednisone first, then either olaparib or observation. The goal is to see if olaparib exte…

This study tests a shorter, higher-dose radiation treatment given before surgery for soft tissue sarcoma of the arm, leg, or trunk. The goal is to see if this approach reduces wound complications after surgery while still controlling the cancer. About 122 adults with resectable s…

This study tests two drugs together for people with small cell lung cancer or other high-grade neuroendocrine cancers that have already been treated. Niraparib blocks a DNA repair protein in cancer cells, while dostarlimab helps the immune system attack the tumor. The goal is to …

This study tests whether a personalized behavior-based program helps people with early liver disease (fatty liver or scarring) manage their condition better than standard care. About 49 adults with risk factors like obesity or diabetes are taking part. The program focuses on life…

This study tested a drug called pembrolizumab in 157 people with rare cancers that had spread or couldn't be removed. The drug works by helping the body's immune system attack the cancer. The main goal was to see how many patients were alive and their cancer hadn't grown after 27…

This study looks at whether adding local treatments like surgery or radiation to standard chemotherapy or hormone therapy can help control breast cancer that has spread to 1-3 spots in the bones. It involves 35 patients with metastatic breast cancer limited to the skeleton. The g…

This study tests whether giving the immunotherapy drug cemiplimab before surgery can shrink tumors in people with stage II to IV head and neck skin cancer that can be surgically removed. About 44 participants will receive cemiplimab to boost their immune system against cancer cel…

This study tests whether adding an experimental vaccine (PDS0101) to standard chemoradiation is safe and effective for people with advanced cervical cancer. The vaccine helps the immune system target HPV-related tumor cells. About 22 adults with stage IB3 to IVA cervical cancer w…

This study tests whether a very low dose of radiation (4 Gy) can effectively treat gastric MALT lymphoma, a type of stomach cancer. About 25 adults with stage I to IV disease will receive this targeted therapy. The goal is to kill tumor cells and shrink tumors while causing fewer…

This study tests a two-part treatment plan for people with multiple myeloma that has come back or is not responding to therapy. First, patients receive daratumumab, bortezomib, and dexamethasone, then switch to daratumumab, ixazomib, and dexamethasone. The goal is to see if this …

This study tests whether combining two immunotherapy drugs, nivolumab and relatlimab, can shrink or control a rare and aggressive kidney cancer called renal medullary carcinoma (RMC) that has spread. About 30 adults with advanced RMC will receive the drug combination. The goal is…

This early-stage trial tests a drug called NBTXR3 that makes radiation more effective at killing cancer cells. It is for people with non-small cell lung cancer that has returned and cannot be removed with surgery. The study aims to find the safest dose and see if combining the dr…

This study tests whether adding telotristat ethyl to standard therapy can help control carcinoid syndrome and prevent heart damage in people with advanced neuroendocrine tumors. About 79 adults whose cancer has spread and who are already on stable somatostatin analog therapy will…

This early-phase study tests a new drug (valemetostat) combined with a standard targeted therapy (trastuzumab deruxtecan) in people with metastatic breast cancer that has low, ultra-low, or no HER2 protein. The goal is to find a safe dose and see if the combination shrinks tumors…

This study tests a combination of two targeted drugs (encorafenib and cetuximab) plus an immunotherapy (nivolumab) in people with a specific type of advanced colorectal cancer (BRAF V600E mutation) that is stable (not MSI-high). The goal is to see if this triple therapy can shrin…

This study tests whether giving a mix of targeted drugs (rituximab, lenalidomide, acalabrutinib, tafasitamab) before and with standard chemotherapy can better control a fast-growing lymphoma called DLBCL. About 62 adults with newly diagnosed disease will take part. The goal is to…

This study tests the safety and effectiveness of combining the immunotherapy drug avelumab with other treatments (utomilumab, anti-OX40 antibody, and radiation) in 173 adults with advanced solid tumors that have spread. The goal is to find the best doses and see if these combinat…

This study tests whether combining rituximab and pembrolizumab (with or without lenalidomide) can shrink tumors in people with follicular lymphoma or diffuse large B-cell lymphoma that has returned after prior treatment. About 53 adults whose cancer came back after at least one p…

This study tested two targeted drugs, dabrafenib and trametinib, given before and after surgery in 58 people with stage III melanoma that has a BRAF gene mutation. The goal was to shrink tumors before surgery and kill any remaining cancer cells afterward. The approach aims to imp…

This study tests whether the drug MGD019 can help control advanced cervical cancer that has spread or come back. About 47 adults with untreated, confirmed cervical cancer will receive the immunotherapy. The main goal is to see if it improves overall survival.

This study tests whether giving two drugs (atezolizumab and bevacizumab) before surgery can help prevent liver cancer from coming back. Sixteen adults with liver cancer that can be surgically removed will receive the drug combination. The goal is to see if the treatment can shrin…

This study tests whether two drugs, venetoclax and azacitidine, can help prevent leukemia from returning in 100 adults who have already had a stem cell transplant. Participants have high-risk acute myeloid leukemia (AML) or related blood cancers and are in remission after transpl…

This study tests whether a blood test that detects tumor DNA can help doctors choose the right treatment for people with advanced colorectal cancer that has not responded to prior therapies. About 100 participants will receive either standard care or treatment guided by the blood…

This study tests a combination of two drugs, dasatinib and venetoclax, in people with early chronic phase chronic myeloid leukemia (CML). The goal is to see if the combination can better control the disease by blocking enzymes that help cancer cells grow. About 155 participants w…

This study tests whether giving two immunotherapy drugs (nivolumab and ipilimumab) along with chemotherapy and radiation before surgery can help treat stomach cancer that can be surgically removed. The trial includes 32 adults with early-stage stomach or gastroesophageal junction…

This study tests whether the drug ixabepilone can help people with HER2-negative breast cancer who still have cancer after standard chemotherapy. About 116 participants will either receive ixabepilone or be observed. The goal is to see if the drug can reduce the risk of cancer co…

This study looks at whether giving radiation therapy to cancer patients whose disease has gotten worse after immunotherapy can help stop or slow the cancer's growth. About 230 adults with cancer that has spread or is in the blood will receive targeted radiation. The goal is to se…

This study tests whether adding the drug sunitinib to standard hormone therapy can better shrink or control high-risk prostate cancer before the prostate is removed. About 64 men with aggressive, localized prostate cancer will receive the combination treatment for a few months, t…

This study tests whether a one-time procedure called brachytherapy, where tiny radioactive seeds are placed directly into the prostate, can control intermediate risk prostate cancer without needing additional treatments. Three hundred men with specific tumor features (Gleason sco…

This study planned to test a combination of two drugs (regorafenib and lorigerlimab) given before surgery to people with a certain type of colorectal cancer that had spread only to the lungs. The goal was to see if the treatment was safe and could help shrink tumors before remova…

This early-phase trial tests whether transferring healthy gut bacteria from donor stool can help control pancreatic cancer. Ten patients scheduled for tumor-removal surgery will receive the transplant to see if it is safe and affects the disease. The study is currently suspended.

This study tests a drug called inotuzumab ozogamicin in 40 adults with B-cell acute lymphocytic leukemia who have minimal residual disease (small numbers of cancer cells left after treatment). The drug is an antibody that delivers a toxin directly to cancer cells. The goal is to …

This study tests whether infusions of cord blood stem cells can help control symptoms of COVID-19-related pneumonia and acute respiratory distress syndrome (ARDS). It involves 65 adults with moderate to critical illness, including those with cancer. The goal is to see if the stem…

This early-phase trial tests whether a shorter course of chemoradiation (2 weeks instead of 5) followed by standard chemotherapy is safe and effective for people with stomach cancer who will have surgery. About 25 participants will receive the shorter radiation along with chemo d…

This study aimed to test a new combination of two drugs (TTI-101 and pembrolizumab) for people with advanced head and neck cancer that had come back or spread. The goal was to see if the combo was safe and could shrink tumors. However, the study was withdrawn before any participa…

This study tests whether combining two or three drugs can shrink or control melanoma that has spread to the brain. About 29 adults with untreated brain metastases will receive bevacizumab and atezolizumab, with or without cobimetinib. The goal is to see if these combinations are …

This study is for people whose head and neck cancer has returned after previous radiation and who cannot have surgery. It compares two radiation techniques: a high-precision, short-course method (stereotactic body radiation therapy) and a standard longer-course method (intensity …

This study was designed to test a combination of two drugs, regorafenib and lorigerlimab, in people whose rectal cancer had come back or continued growing after standard treatment. The goal was to see if the combination was safe and could control the cancer. However, the trial wa…

This study tests whether giving radiation and chemotherapy at the same time can better control stage I or II nasal NK cell lymphoma. About 26 newly diagnosed adults are receiving this combination to see if it improves how long the disease stays away. The goal is to manage the can…

This early-phase study tests whether adding the immunotherapy drug durvalumab to standard chemotherapy (carboplatin and paclitaxel) can help control advanced ovarian, fallopian tube, or primary peritoneal cancer. About 18 women with stage III or IV cancer will receive the combina…

This study tests whether a fecal microbiota transplant (transferring healthy bacteria from stool) can help the immune system respond to anti-PD-1 drugs like pembrolizumab or nivolumab in people with advanced colorectal cancer who previously did not respond to these immunotherapie…

This early-phase study tests the safety and best dose of combining two types of drugs—an mTOR inhibitor (sirolimus, everolimus, or temsirolimus) and vorinostat—in people with advanced cancer that hasn't responded to standard treatments. The goal is to find a tolerable dose that m…

This study tests a new combination of three drugs (azacitidine, venetoclax, and pevonedistat) in adults with a difficult-to-treat form of acute myeloid leukemia (AML). The goal is to find the best dose and see how well the drugs work together to control the cancer. About 40 parti…

This study tests whether adding the drug venetoclax to a specific chemotherapy regimen before a donor stem cell transplant can help people with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) live longer without their cancer returning. About 116 adults aged 18 to 7…

This study looks at whether a program that focuses on parents and families can help African American families lose weight. Obesity often runs in families, so the program uses parents as the main leaders for change. The goal is to see if this approach can help families manage thei…

This study tests the immunotherapy drug nivolumab in 16 people with advanced solid tumors that have spread or can't be removed by surgery. Participants must have a specific genetic change (ARID1A mutation) and a protein marker (CXCL13) in their tumors. The goal is to see if nivol…

This study aimed to find safe doses of two experimental drugs (lisaftoclax and pelcitoclax) combined with standard FLAG chemotherapy for adults with T-cell acute lymphoblastic leukemia that returned or didn't respond to treatment. The trial was withdrawn before enrolling any part…

This early-phase study tests whether giving acalabrutinib and rituximab followed by brexucabtagene autoleucel (a CAR T-cell therapy) can help control high-risk mantle cell lymphoma in people who have not yet been treated. About 22 participants will receive the treatment, and rese…

This study tests a new drug, seclidemstat, combined with a standard drug, azacitidine, for people with myelodysplastic syndromes (MDS) or chronic myelomonocytic leukemia (CMML). The goal is to find the best dose and see if the combination can shrink or control the cancer. About 2…

This study compares two treatments for early-stage non-small cell lung cancer: targeted radiation alone versus radiation plus the immunotherapy drug nivolumab. About 140 adults with stage I-IIA or recurrent lung cancer will participate. The goal is to see if adding immunotherapy …

This study tests whether freezing some tumors (cryoablation) can help standard immunotherapy work better in people with metastatic cancer. About 15 participants will receive both treatments. The goal is to see if this combination shrinks more tumors and delays cancer growth.

This study tests whether adding abiraterone and prednisone to standard hormone therapy works better than hormone therapy alone for men whose prostate cancer has come back after surgery or radiation. About 310 men will receive either hormone therapy or hormone therapy plus abirate…

This study tests whether giving two immunotherapy drugs (tiragolumab and atezolizumab) before and after standard surgery and chemoradiation can help control advanced oral cancer. It includes 29 adults with newly diagnosed, stage 3-4 oral cavity squamous cell carcinoma that has a …

This study tests a new drug combination for people with a specific type of advanced lung cancer (EGFR-mutant non-small cell lung cancer). The two drugs, LY3295668 and osimertinib, work by blocking enzymes that help cancer cells grow. The goal is to find the safest dose and see if…

This study was designed to find a safe dose of revumenib when given with standard chemotherapy drugs to children and young adults with acute leukemia. It was planned for two phases: first to test safety, then to see if the combination helps control the disease. However, the trial…

This study tests a drug called AK104 (Cadonilimab) in 18 adults with a rare, aggressive cervical cancer that has returned or spread after standard chemotherapy. The goal is to see if the drug can stop the cancer from growing for at least 6 months. Participants receive the drug al…

This study looks at 180 people with kidney cancer that has spread. It compares six different ways to give two drugs (everolimus, bevacizumab, or pazopanib) one after the other. The goal is to see which sequence works best and is safest for controlling the cancer.

This study tests a combination of two drugs, lenvatinib and pembrolizumab, in 25 people with advanced anaplastic thyroid cancer that cannot be removed by surgery or has spread. Lenvatinib blocks enzymes that help cancer cells grow, while pembrolizumab helps the immune system atta…

This study tests a drug called talazoparib in 150 people with advanced cancers that have not responded to standard treatments. The drug works by blocking an enzyme that helps cancer cells repair themselves, which may cause them to die. The study focuses on patients whose tumors h…

This study tests whether the drug cemiplimab can control a specific type of colon cancer (dMMR) without needing surgery. About 50 adults with early-stage colon cancer that has not spread will receive the drug. The main goal is to see if the treatment is safe and effective at cont…

This study aimed to see if the drug ASTX727, alone or with donor immune cells, could help control blood cancers in people who already had a stem cell transplant. It was designed for adults aged 18-75 with certain high-risk blood cancers. However, the study was withdrawn before en…

This early-phase trial tested the drug olaparib in 15 people with newly diagnosed BRCA-mutant ovarian, fallopian tube, or peritoneal cancer before they had surgery. The goal was to see if taking olaparib for two cycles could shrink tumors or stop them from growing. Olaparib works…

This study tests whether adding the drug panitumumab to standard chemotherapy helps shrink tumors more effectively in people with a rare and aggressive type of breast cancer called triple-negative inflammatory breast cancer. About 42 participants will receive chemotherapy before …

This early-phase study tests whether adding a new drug called IM156 to standard chemotherapy (gemcitabine and nab-paclitaxel) is safe for people with advanced pancreatic cancer. About 19 adults with confirmed advanced disease are taking part. The main goal is to check for side ef…

This study looks at whether combining a nightly fasting period with the diabetes drug metformin can reduce breast cancer cell growth in women with early-stage invasive breast cancer or ductal carcinoma in situ (DCIS). About 120 participants will follow a fasting schedule and take…

This study tests whether adding an experimental drug (GSK2636771) to an approved immunotherapy (pembrolizumab) can help control metastatic melanoma in patients whose tumors have lost a gene called PTEN. Up to 41 adults with advanced melanoma that hasn't responded to prior treatme…

This study tests two treatment options for people with advanced kidney cancer that has spread and continued to grow after immunotherapy. One group gets a combination of two drugs (lenvatinib and everolimus), while the other gets a single drug (cabozantinib). The goal is to see wh…

This early-stage study tests a new antibody drug called Hu8F4 in 72 people with advanced blood cancers like leukemia and myelodysplastic syndrome. The main goals are to find the safest dose and check for side effects. Researchers hope the antibody can stop cancer cells from growi…

This early-phase trial tests an inhaled form of the immune-boosting drug aldesleukin (IL-2) in 70 people whose cancer has spread to the lungs. The goal is to find the safest and most effective dose, and to see if it can shrink tumors. Participants have cancers like melanoma, kidn…

This early-phase study tests whether injecting the cancer drug nivolumab directly into high-risk mouth lesions is safe and can shrink or eliminate them. About 18 adults with biopsy-proven oral premalignant lesions will receive the injections. The goal is to control these lesions …

This study is for adults with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) who have not yet had treatment. It tests a combination of two drugs: zanubrutinib (which blocks a protein that helps cancer cells grow) and rituximab (an antibody that helps the i…

This study tests a treatment for CMV infection that persists or returns after standard therapy in people who have had a stem cell transplant. The treatment uses specially selected white blood cells from donors who have been exposed to CMV. These cells are given to the patient to …

This study tests whether a diet rich in prebiotic foods can help the immune system better fight advanced melanoma that no longer responds to standard immunotherapy. Four adults with stage III or IV melanoma will eat a prebiotic-enriched diet while receiving a combination of two i…

This study tests a combination of three drugs (pemetrexed, etrumadenant, and zimberelimab) in 10 adults with advanced bladder cancer that has a specific genetic change called MTAP deficiency. All participants had prior immunotherapy that stopped working. The goal is to see if thi…

This study tests whether adding the drug ixazomib to standard chemotherapy (gemcitabine and doxorubicin) can shrink tumors or stop them from growing in people with a rare and aggressive kidney cancer called renal medullary carcinoma. About 30 patients with advanced or spreading d…

This study tests whether two drugs, lenvatinib and everolimus, can shrink or slow the growth of advanced carcinoid tumors that cannot be removed by surgery. About 36 adults with this rare cancer will receive the combination. The goal is to see how well the drugs control the disea…

This early-phase study tests whether combining two drugs, pembrolizumab and lenvatinib, can help control advanced pancreatic cancer that has not responded to prior treatment. Fifteen adults with metastatic pancreatic cancer will receive the combination. The goal is to see if the …

This study tests a combination of two drugs, azacitidine and quizartinib, in 30 adults with myelodysplastic syndromes or related blood cancers that have specific gene changes (FLT3 or CBL). The goal is to find the best dose and see how well the drugs control the disease. Particip…

This early-phase study tests whether a new treatment called KSQ-001EX is safe for people with advanced solid tumors like melanoma, lung cancer, or head and neck cancer. The treatment uses a patient's own immune cells (tumor-infiltrating lymphocytes) that are genetically modified …

This study aimed to see if the immune therapy BALSTILIMAB could clear lingering HPV virus in throat cancer patients who still had virus in their blood after completing standard treatment. The goal was to reduce the risk of cancer coming back. However, the trial was withdrawn befo…

This early-stage trial tests a new drug called adagrasib combined with two existing cancer drugs (cetuximab and irinotecan) in people with advanced colorectal cancer that has a specific genetic change called KRAS G12C. The main goal is to find a safe dose and check for side effec…

This study tests different combinations of approved drugs in 196 men with advanced prostate cancer that has spread and no longer responds to hormone therapy. The goal is to see which combinations work best to extend life and control the cancer. Participants receive standard hormo…

This early-phase trial tests the drug AL101 given before standard surgery in 14 people with a rare salivary gland cancer called adenoid cystic carcinoma that has a specific genetic change (NOTCH activation). The goal is to see if AL101 is safe and can help control the tumor befor…

This study tests a combination of two drugs, acalabrutinib and rituximab, in people aged 65 and older with newly diagnosed mantle cell lymphoma who haven't had treatment yet. Acalabrutinib blocks enzymes that help cancer grow, while rituximab targets and kills cancer cells. The g…

This early-phase study tests whether the drug regorafenib can help control gastrointestinal stromal tumors (GIST) that have specific genetic changes (KIT exon 17, 18, or 14 mutations, or SDHB deficiency) after imatinib has stopped working. Only 3 adults with measurable, unresecta…

This study tests a combination of two drugs, venetoclax and ASTX727, in adults with acute myeloid leukemia (AML) that has returned or not responded to treatment, as well as in older adults newly diagnosed with AML who cannot handle strong chemotherapy. The goal is to see if this …

This study tests whether a personalized cell therapy called liso-cel can stop large B-cell lymphoma from returning in patients who still have traces of cancer DNA after initial treatment. About 50 adults who are in remission but test positive for lymphoma DNA will receive their o…

This study tests whether giving three drugs (pembrolizumab, dabrafenib, and trametinib) before surgery can help people with a rare and aggressive thyroid cancer called anaplastic thyroid cancer that has a specific gene change (BRAF V600E). The goal is to shrink the tumor enough s…

This study tests a new treatment for older or medically frail adults with B-cell acute lymphoblastic leukemia (a fast-growing blood cancer). The treatment combines a targeted drug (blinatumomab, given as a shot under the skin) with low-intensity chemotherapy. The goal is to see i…

This study tests a drug called ibrutinib in 20 people with a slow-growing type of lymphoma that hasn't been treated yet. The goal is to see if the drug can stop the cancer from getting worse by blocking certain enzymes cancer cells need to grow. Participants must have no symptoms…

This early-phase study tests whether combining two immunotherapy drugs (tiragolumab and atezolizumab) with a special type of radiation (RadScopal) is safe and can help shrink tumors in people with advanced solid cancers that have not responded to standard treatments. The trial in…

This early-phase trial is testing two drugs, niraparib and copanlisib, together in people whose endometrial, ovarian, or related cancers have returned. The main goal is to find the safest dose and understand side effects. About 31 adults with specific cancer types are taking part…

This study tests whether adding hydroxychloroquine (a drug used for malaria) to standard chemotherapy can help control osteosarcoma that has returned or stopped responding to treatment. About 31 participants will receive the combination to find the best dose and see if it slows t…

This early-phase study tests the safety and best dose of combining two drugs (bevacizumab and temsirolimus) with one of three other cancer drugs for people with advanced cancer that hasn't responded to standard treatments. About 278 participants will receive one of the combinatio…

This early-phase study tests a portable device that creates electric fields to stop cancer cells from growing, combined with chemotherapy and a targeted drug. It is for people whose cancer has spread to the liver and is not responding to standard treatments. The goal is to find t…

This study tests whether combining lenalidomide and rituximab can help control chronic lymphocytic leukemia or small lymphocytic lymphoma. About 120 adults who either haven't been treated or have had prior therapy will receive the drug combination. The goal is to shrink or slow c…

This study tests whether proton beam therapy, sometimes combined with standard radiation, can control skull base chondrosarcoma—a rare tumor at the base of the skull. Fifteen adults who had surgery to remove as much tumor as possible will receive this targeted radiation. The main…

This study tests adding the targeted drug sorafenib to standard chemotherapy (busulfan and fludarabine) before a donor stem cell transplant in adults with acute myeloid leukemia that has returned or not responded to treatment. The goal is to find the safest dose of sorafenib and …

This study tests whether a home-based weight loss program, with or without resistance training, is practical and effective for endometrial cancer survivors. Fifteen participants who completed cancer treatment will follow a diet and exercise plan using a Fitbit and phone coaching.…

This study tests a combination of three drugs—ixazomib, gemcitabine, and doxorubicin—in people with advanced bladder cancer that has spread or cannot be removed by surgery. The goal is to find the safest dose and see if the combo can shrink tumors. About 57 adults will take part …

This study is for people with early HER2-positive or triple-negative breast cancer whose tumors completely disappeared after initial treatment before surgery. Researchers want to see if giving less therapy after surgery can still keep the cancer away while reducing side effects. …

This study tests a combination of three drugs—ALX148, rituximab, and lenalidomide—in people with B-cell non-Hodgkin lymphoma that has come back or not responded to prior treatment. The goal is to find the best dose and see how well the combo controls the cancer. About 47 adults w…

This early-phase study tests a special bacteria (Clostridium novyi-NT) injected directly into tumors, combined with the immunotherapy drug pembrolizumab, for people with advanced solid tumors that haven't responded to standard treatments. The goal is to find the safest dose and s…

This study tests a combination of three drugs (abiraterone, prednisone, and apalutamide) in 60 men whose prostate cancer has spread but who have not yet received hormone therapy. The goal is to see how long patients can stay on treatment and to measure cancer progression and side…

This study looked at whether adding the drug cidofovir to usual care helps people who develop painful bladder bleeding from the BK virus after a stem cell transplant. About 27 participants received either cidofovir or standard supportive care. The goal was to see if symptoms impr…

This study was designed to test the safety of a new drug called MT-0169 in people with acute leukemia that has come back or not responded to treatment. It was planned for patients aged 12 and older with specific types of leukemia. However, the trial was withdrawn before enrolling…

This study tests a drug called brentuximab vedotin in 79 people with rare skin lymphomas (ALCL, mycosis fungoides, or lymphomatoid papulosis) that have a marker called CD30. The goal is to see if the drug can shrink or control the cancer. Participants receive the drug every 3 wee…

This study tests a radioactive drug (177Lu rhPSMA-10.1) alone or with hormone therapy in men with high-risk prostate cancer before they have surgery. The goal is to see if the drug is safe and can shrink the tumor. Only 6 men are taking part in this early-phase trial.

This study tests a combination of two drugs (avelumab and M6620) in people with advanced solid tumors that have spread or can't be removed by surgery. The tumors must have specific DNA repair gene changes. The goal is to find the safest dose and see if the combo can shrink or con…

This study looks at whether varenicline (a prescription drug) or the nicotine patch helps people quit smoking more effectively, depending on their natural levels of emotion and attention. About 204 adult smokers who smoke at least 5 cigarettes daily will receive behavioral counse…

This study tests a combination of two drugs—tagraxofusp and decitabine—for people with chronic myelomonocytic leukemia (CMML) and related blood cancers. Tagraxofusp targets and kills cancer cells, while decitabine is a standard chemotherapy that stops cancer growth. The goal is t…

This study tests a combination of four drugs (brentuximab vedotin, pembrolizumab, doxorubicin, and dacarbazine) in 25 people with untreated advanced Hodgkin lymphoma. The goal is to see if this approach can control the disease while reducing side effects. Participants have stage …

This study tests whether taking apalutamide for 6 months before prostate removal surgery can reduce signs of aggressive cancer that often lead to radiation therapy afterward. It involves 45 men with intermediate-risk prostate cancer. The goal is to see if this approach can make s…

This study looks at whether a combined PET/MRI scan can more accurately measure the depth of cervical cancer and check for lymph node spread in 25 women with early-stage disease (IA1-IB3) who are scheduled for surgery. The goal is to improve how doctors determine the cancer stage…

This study tests contrast-enhanced mammography (CEM), a special X-ray that uses an injected dye to make breast tissue and blood vessels clearer. It aims to see if CEM can find breast cancer more accurately than standard mammograms and help doctors choose the best spots for biopsy…

This study tests a new 3D MRI method to improve prostate cancer imaging without using a special coil inside the body. About 33 men with untreated, intermediate- or high-risk prostate cancer will be scanned before surgery. The goal is to see if the new technique provides clearer i…

This study looks at whether combining PET/CT scans with a special dye can better detect cancer that has spread to lymph nodes in women with high-risk endometrial cancer. About 100 participants will get both imaging methods before surgery. The goal is to see if these techniques ca…

This study tests a new radioactive tracer called [18F]FluorThanatrace (FTT) used with PET/CT scans to improve breast cancer imaging. About 36 adults with known breast cancer will receive the tracer before standard surgery or biopsy. The goal is to see if FTT can help detect an en…

This study tests whether special imaging devices can better detect pre-cancerous or cancerous spots in the mouth compared to a standard visual exam. About 63 adults with suspicious mouth lesions or a history of oral cancer will be followed over time. The goal is to see if these a…

This study compares two imaging techniques—CT urography and intravenous urography—to see which works better for detecting urothelial tumors in people at risk of bladder cancer. About 133 participants will receive both scans as part of their routine care. The goal is to determine …

This study looks at whether a special type of mammogram (contrast-enhanced mammography) can more accurately predict breast cancer in women with suspicious calcium spots in the breast. About 59 women will be enrolled to compare this new imaging method with standard mammograms. The…

This study tests whether a low-radiation CT scan, enhanced with artificial intelligence software, can detect liver metastases as accurately as a standard CT scan. About 146 adults with colorectal cancer and known liver tumors will receive both types of scans. The goal is to see i…

This study tests a special contrast agent called hyperpolarized 13-C pyruvate during MRI scans to see if it can show prostate tumors more clearly than standard imaging. About 130 men with prostate cancer will be scanned at two hospitals. The goal is to improve how doctors find an…

This study compares two imaging methods—PET/MR and standard CECT scans—to see which better locates ovarian cancer tumors in 21 women with known or suspected ovarian cancer. The goal is to improve how doctors predict whether tumors can be fully removed by surgery and how patients …

This study is testing a new imaging tracer called 18F-FSPG to see if it can better find and diagnose liver cancer (hepatocellular carcinoma) before surgery or transplant. About 110 adults with liver tumors will receive the tracer and undergo a PET scan. The goal is to compare how…

This study tests whether using two contrast agents in MRI scans helps doctors find and identify liver lesions (both non-cancerous and cancerous) more accurately. About 100 adults with recent abdominal MRIs will receive two contrast dyes to see which combination gives clearer imag…

This small pilot study tests whether a special PET scan called Axumin can help doctors tell the difference between real tumor growth and treatment-related inflammation (pseudo-progression) in people with brain metastases who are on immunotherapy. The study enrolled 3 adults with …

This study looks at whether a special type of CT scan, called dual energy CT, can better detect carcinoid tumors in the digestive system. About 71 people with signs or confirmed carcinoid tumors will get this scan during a routine check-up. The goal is to see if this imaging meth…

This early-phase study tests how well a special PET-CT scan called FAZA can measure oxygen levels in solid tumors like breast, colorectal, and pancreatic cancers. About 25 participants will receive the FAZA tracer and undergo imaging to see if the results are consistent over time…

This study compares MRI and CT scans to see which better detects thymoma tumors and their spread in the chest. About 40 adults with newly diagnosed or recurring thymoma will get both scans before surgery. The goal is to find if MRI can replace CT, potentially offering a radiation…

This study tests whether a special whole-body MRI can accurately find cancer spread to bones or lymph nodes in men with high-risk prostate cancer. About 98 participants will get this MRI along with standard bone and CT scans. The goal is to see if the MRI is as good or better at …

This study tests whether special lights and cameras can help find early signs of mouth cancer in people at high risk. About 338 participants with precancerous spots or conditions like Fanconi anemia will have their mouths examined with fluorescence imaging, which makes abnormal c…

This study tests whether a modified MRI scan (called Dixon sequencing) can produce clearer images of prostate cancer than the standard MRI. Researchers will compare the two methods in 65 men who have prostate cancer and are scheduled for prostate removal. The goal is to see if th…

This study looks at how to increase HPV vaccination rates among young adults aged 18-26 in Texas. Researchers will test different ways to encourage college students who haven't had the vaccine to start and complete the series. The goal is to prevent HPV infections and related can…

This study looks at whether programs focused on parents or the whole family can help reduce obesity risk in African American families. Obesity often runs in families, so these programs aim to lower that risk and possibly prevent obesity-related cancers. About 120 parent-child pai…

This study tests whether giving whole brain radiation to people with small cell carcinoma of the bladder (a rare and aggressive cancer) can lower their risk of developing brain tumors. It includes 31 patients whose cancer responded well to chemotherapy. The main goal is to see ho…

This study looks at whether a lifestyle program focusing on diet and exercise can reduce breast cancer risk in normal-weight postmenopausal women who have excess body fat. The goal is to change body composition and lower inflammation. About 40 women will take part to see if the p…

This study tests if acupuncture can prevent dry mouth in 435 head and neck cancer patients getting radiation. Dry mouth is a common side effect that affects quality of life. Researchers compare different acupuncture methods to see which works best.

This study looks at whether eating a diet high in magnesium can help prevent low blood magnesium levels in ovarian cancer patients receiving carboplatin chemotherapy. About 26 women with previously untreated ovarian cancer will follow a magnesium-rich diet during their treatment.…

This pilot study looks at whether adding hunger training to a standard diabetes prevention program helps obese women at high risk for breast cancer lose weight and lower their cancer risk. About 51 participants will learn weight-loss strategies and how to recognize true hunger. T…

This study tests a program called Tu Salud Si Cuenta! that helps Latino families adopt healthier lifestyles. About 600 participants will receive guidance on eating more fruits and vegetables and increasing physical activity. The goal is to see if this approach can lead to lasting…

This study tests whether a program that includes diet advice, physical activity, stress management, mindfulness, sleep tips, and counseling can help prevent breast cancer in premenopausal women at higher risk. About 60 women will take part to see if the program is practical and w…

This study looks at whether a program called Tu Salud Si Cuenta can help Latino families eat healthier and be more active. About 80 adults will get home visits from a community health worker over 6 months. The goal is to see if this approach can help prevent cancer and improve qu…

This study looks at two types of surgery to prevent ovarian cancer in women aged 30-50 who have gene mutations that raise their risk. One surgery removes both the fallopian tubes and ovaries, while the other removes only the tubes first and delays removing the ovaries. The goal i…

This study tests a program to help people with BRCA+ or Lynch syndrome mutations lose weight and adopt healthier habits like better diet and more exercise. The goal is to lower their risk of developing cancer. About 384 participants and their family members will take part in the …

This study tests different programs to help people at high risk for cancer (such as those with BRCA or Lynch syndrome) or cancer survivors increase their physical activity and eat healthier. The goal is to see which programs work best to reduce cancer risk. About 337 participants…

This study looks at whether eating canned, pre-cooked beans can improve the balance of healthy bacteria in the gut and reduce the effects of obesity on colorectal cancer risk. About 70 adults who are overweight or have a history of colorectal cancer or precancerous polyps will pa…

This study tests whether injecting bone cement into the spine can prevent fractures in cancer patients receiving high-dose radiation for tumors that have spread to the spine. About 87 adults with solid tumors and spinal metastases are taking part. The goal is to see if this simpl…

This study tests whether using home sensors to monitor dehydration risk can reduce hospitalizations and emergency room visits in head and neck cancer patients. About 427 participants will either use the CYCORE sensor system plus standard care, or standard care alone. The goal is …

This study tests a surgical procedure called vascularized lymph node transfer to prevent lymphedema (arm swelling) in 30 breast cancer patients having breast reconstruction. The surgeon moves healthy lymph nodes from another body area to replace those removed during cancer treatm…

This study looks at three approaches to prevent ovarian cancer in women with BRCA1 or BRCA2 gene mutations: regular screening, removing both fallopian tubes and ovaries at once, or removing only the fallopian tubes first and the ovaries later. The two-step surgery aims to delay m…

This study tests a mindfulness program adapted for Latino cancer patients and their family caregivers. The goal is to see if it helps reduce stress and anxiety and improves mental well-being. About 68 patient-caregiver pairs will take part, and researchers will measure how well t…

This study tests whether manual therapy—gentle massage and stretching of the neck, throat, jaw, and mouth—can improve swallowing and movement in head and neck cancer survivors who have long-term swallowing problems due to tissue scarring (fibrosis). About 24 survivors who finishe…

This study looks at whether draining fluid from the chest every day helps people with advanced cancer breathe better compared to draining it only three times a week. About 257 adults with cancer-related fluid buildup around the lungs will have a small tube placed and be randomly …

This study tests whether a supervised, at-home resistance training program using a tablet is safe and helpful for people with advanced pancreatic cancer or those recovering from surgery. About 25 participants will do guided exercises during chemotherapy or after surgery. The goal…

This study tests an exercise program designed for Hispanic women who have had breast cancer. The goal is to find the best ways to help them become more physically active. Researchers will measure changes in exercise habits and look at certain health markers in the blood. The stud…

This study tests whether a meditation-based mind-body program can improve quality of life for adolescents and young adults (ages 18-39) recently diagnosed with lymphoma. Participants practice guided meditation and mindfulness techniques to help lower distress, anxiety, and depres…

This study looks at whether combining exercise, supportive counseling, and a stimulant drug (methylphenidate) can help reduce severe fatigue in prostate cancer patients who are receiving radiation and hormone therapy. About 175 adults with prostate cancer and daily fatigue will b…

This study tests whether an online mind-body program for couples can improve quality of life for people with brain tumors (glioma or metastatic brain cancer) and their partners. About 74 couples will take part. The program focuses on spiritual well-being, sleep, mood, and overall…

This pilot study tests whether a smartphone app can help current smokers quit. Researchers will track mood, activity, and satisfaction in 24 participants. The goal is to see if the app improves smoking abstinence and overall well-being.

This study tested whether a technique called neurofeedback can help reduce pain caused by radiation therapy in people with head and neck cancer. Neurofeedback uses a computer to show patients their own brain activity and teaches them how to change it to feel less pain. The study …

This study tests whether an 8-week program of text messages sent to your phone can help you sit less and move more. About 228 adults who sit for more than 6 hours a day will receive texts encouraging healthy habits. Their activity is tracked with a Fitbit to see if the messages m…

This study looks at whether a supervised exercise program can improve physical fitness in people with bone cancer before they have surgery. About 45 patients will take part, and the main goal is to see if the program is practical and safe. The researchers will also check if exerc…

This study looks at whether Scrambler therapy can safely reduce painful nerve damage caused by chemotherapy in adolescents and young adults (ages 15-39) who have finished active cancer treatment. Participants are randomly assigned to receive the therapy right away or after a wait…

This study tests whether a type of counseling called behavioral activation therapy, combined with nicotine patches or gum, helps people quit smoking more than standard support. It focuses on smokers who have low reward sensitivity, meaning they get less pleasure from everyday act…

This study looks at how well two drugs, haloperidol and lorazepam, can control severe agitation and confusion (delirium) in people with advanced cancer who are in palliative care. About 110 patients will be enrolled to compare different drug approaches. The goal is to improve com…

This study looks at whether adding a steroid drug called dexamethasone to a physical activity program can help reduce severe tiredness in people with advanced cancer. About 99 adults with fatigue lasting at least 2 weeks will take part. The goal is to see if the combination is pr…

This study looks at whether exercising the muscles used for coughing and swallowing can reduce the risk of pneumonia in people who had radiation for head and neck cancer. About 175 survivors are involved. The main goal is to see if stronger cough muscles help prevent food or sali…

This study looks at a fast way to spot depression in women with ovarian, peritoneal, or fallopian tube cancer. It compares a special support program to standard care to see which better improves quality of life. About 409 women on active cancer treatment took part.

This study compares two pain management approaches—neurofeedback (brain wave training) and a supportive care team—against standard care in 28 head and neck cancer patients at risk for opioid misuse. The goal is to see if these methods can lower pain and reduce the need for opioid…

This study tests a mobile lifestyle program for women with breast cancer who have unhealthy habits. The program offers coaching on diet, exercise, stress management, mindfulness, and sleep. Researchers want to see if it's practical and helps improve quality of life. About 30 wome…

This study looks at whether a drug called anamorelin can help improve appetite and prevent weight loss in people with advanced non-small cell lung cancer who have lost their appetite and are losing weight. About 25 participants will take either the drug or a placebo and share the…

This study tests if a program combining gentle yoga and Christian spirituality is practical and well-liked by inactive Black adults in Northeast Texas. About 50 participants will take part to see if the program helps improve their mood and overall wellbeing. The goal is to find a…

This study looks at whether a yoga program is practical and helpful for people with head and neck cancer who are getting radiation therapy, along with their family caregivers. About 236 couples will take part to see if yoga can improve quality of life, reduce fatigue, sleep probl…

This study tested whether simple breathing exercises and meditation could help healthcare workers at MD Anderson Cancer Center manage stress and improve lung health during the COVID-19 pandemic. About 100 workers participated. The main goals were to see if people would join the s…

This study looks at whether a single large dose of radiation is better than three smaller doses for treating spine tumors that have returned after earlier radiation. About 80 adults with cancer that spread to the spine will be randomly assigned to one of the two treatments. The g…

This study tests a program that combines mood management with health and wellness coaching to help pregnant smokers who are depressed quit smoking and stay smoke-free after their baby is born. About 26 participants will take part during pregnancy and after birth. The goal is to s…

This study looks at whether regular exercise and behavioral skills training can improve physical fitness and quality of life in people with pancreatic cancer who are getting chemotherapy or radiation before surgery. About 128 participants will take part at MD Anderson. The main g…

This study looks at whether adding yoga therapy to standard chemotherapy and radiation can improve the physical and emotional well-being of people with cervical cancer. About 40 patients with stage IB2 to IIIB cervical cancer will take part. The yoga program includes gentle exerc…

This study looks at whether adding a technology-based symptom monitoring program to regular palliative care (in-person and remote visits) can improve quality of life for people with advanced solid tumors who are also in phase 1 immunotherapy trials. About 119 participants will us…

This study tests whether a non-invasive technique called navigated repetitive transcranial magnetic stimulation (nrTMS) can help people with brain tumors recover movement after surgery. About 32 patients who recently had surgery for a brain tumor near the movement-control area of…

This study compares a new counseling approach called Acceptance and Commitment Therapy (ACT) with standard counseling to help people with head and neck, lung, breast, gastrointestinal, or genitourinary cancer stop smoking. About 51 adults who smoke at least one cigarette per day …

This study tests a highly targeted radiation treatment for people whose cancer has spread to the spine, causing pain. Researchers want to see if this approach is safe and effective at relieving pain. About 150 participants will receive the treatment and report their pain levels o…

This study tests a training program for family members caring for someone with a high-grade glioma. The goal is to help caregivers feel less stressed and more confident, and to improve the patient's symptoms and quality of life. About 124 pairs of caregivers and patients will tak…

This study looks at whether adding lorazepam to haloperidol can better reduce delirium (sudden confusion and agitation) in people with advanced cancer who are in a palliative care unit. About 93 participants will receive either haloperidol alone or with lorazepam, and their level…

This study compares two different methods for prescribing opioid pain medication to people with abdominal cancer after surgery. The goal is to find which method provides better pain control with fewer side effects. About 170 adults having certain types of abdominal surgery will t…

This study tests whether a drug called anamorelin, combined with physical activity and nutritional counseling, can reduce severe fatigue in people with advanced solid tumors that have spread or returned. About 129 participants with incurable cancers and high fatigue levels will r…

This study tests whether dexamethasone, a steroid medicine, can reduce shortness of breath in people with cancer. About 135 participants with moderate to severe breathing trouble will receive the drug or a placebo. The goal is to see if it improves breathing and quality of life o…

This study tests whether adding a short course of the steroid dexamethasone to a physical activity program can better reduce severe fatigue in people with advanced cancer. About 90 participants will be randomly assigned to receive either a high or low dose of dexamethasone along …

This study tests a special check-up and support program for adults 65 and older who have finished treatment for early-stage breast cancer. The goal is to improve their overall health and quality of life by addressing physical, mental, and emotional needs. Participants will comple…

This study tests whether giving a second numbing injection (quadratus lumborum block) after surgery for retroperitoneal sarcoma can reduce the need for opioid painkillers. About 113 patients will receive either one or two injections of liposomal bupivacaine. The goal is to see if…

This study tests a procedure called cordotomy for people with advanced cancer who have severe pain that is not controlled by usual treatments. A needle is guided by CT scans to the spinal cord to reduce pain signals. The goal is to see if this procedure can lower pain intensity a…

This pilot study tests a new way to help people with chemotherapy-induced nerve pain identify what matters most to them, shifting care from just treating the disease to caring for the whole person. About 33 adults with this condition will use a smartphone-based program to set per…

This study looks at whether a yoga program for head and neck cancer patients and their family caregivers can improve quality of life and reduce hospital visits during and after chemoradiation. About 415 patient-caregiver pairs will take part. The goal is to see if yoga is a helpf…

This study tests whether combining cognitive behavioral therapy with medications (methylphenidate, melatonin) and light therapy can improve sleep in cancer patients. About 68 adults with cancer and poor sleep (PSQI score 5 or higher) are participating. The goal is to reduce sleep…

This study tests a non-invasive therapy called neurofeedback training to help cancer patients learn to change their own brain waves and reduce pain from chemotherapy-related nerve damage. About 80 participants will be assigned to either receive neurofeedback or be in a control gr…

This study compares two ways to manage pain after liver cancer surgery: thoracic epidural analgesia and a four-quadrant nerve block. About 100 adults having open liver surgery at MD Anderson Cancer Center will be randomly assigned to one method. The goal is to see which approach …

This study looks at whether listening to a self-hypnosis audio before surgery can help women with gynecologic cancer feel less pain and recover faster. About 152 patients having surgery for cancers of the female reproductive system will be randomly assigned to either usual care o…

This study looks at how cancer patients feel about using marijuana products (THC or CBD) compared to standard pain treatments. Researchers want to understand if patients prefer adding marijuana to their pain plan over using opioids alone. The goal is to learn more about how these…

This study tests high-dose steroids (prednisone or methylprednisolone) to see if they can improve symptoms of nerve damage caused by past radiation treatment in head and neck cancer survivors. The trial involves 35 adults who are at least two years past radiation and have specifi…

This study looks at whether haloperidol, given alone or with chlorpromazine, can safely reduce severe agitation and confusion (delirium) in 70 adults with advanced cancer who are in a palliative care unit. The goal is to find the best way to calm patients without oversedating the…

This study tests an online program designed to help women with lung cancer feel more supported and less distressed during treatment. The program uses techniques like mindfulness and emotional processing to improve social well-being. About 70 women with stage I-IV non-small cell l…

This study looks at whether a regular exercise program is practical for women aged 65 and older who are receiving chemotherapy for early-stage breast cancer. Participants will be asked to walk and do arm exercises several times a week. The goal is to see if exercise can reduce th…

This study looks at whether people with throat cancer on one side of the neck can safely receive radiation to only that side, instead of both sides. The goal is to reduce side effects from unnecessary radiation. About 8 participants with early-stage HPV-related tonsil or tongue b…

This study tests whether a long-acting numbing medicine called EXPAREL can reduce pain better than the standard lidocaine in people with lung cancer who need a procedure to drain fluid from around the lungs. About 80 adults will be randomly assigned to receive one of the two medi…

This study looks at whether hypnosis can help women with early-stage breast cancer relax during surgery and reduce the need for general anesthesia. About 50 women will try hypnosedation, a technique that uses words and images to keep them calm and awake while numb. The goal is to…

This study tested whether a shorter course of higher-dose radiation (hypofractionated) works as well as standard radiation for early-stage breast cancer. About 300 women with ductal carcinoma in situ or early invasive breast cancer took part. The goal was to see if the shorter tr…

This study looks at whether an integrative oncology program—including diet advice, physical activity, stress management, social support, and reducing exposure to environmental toxins—can improve outcomes for women with stage II or III breast cancer who are receiving radiation the…

This study looks at whether a type of acupuncture that uses mild electrical pulses can help reduce chronic pain in women who have finished treatment for early-stage breast cancer. About 111 women who have had pain for at least 3 months after surgery will be randomly assigned to r…

This early-stage study tests the safety and best dose of radiation therapy for people with liver cancer who also have liver damage from cirrhosis, chemotherapy, or surgery. The goal is to find a dose that kills cancer cells without causing severe side effects. About 36 adults wit…

This study tests whether the drug ruxolitinib (Jakafi) can reduce severe fatigue in people with chronic lymphocytic leukemia (CLL) who do not yet need standard treatment. About 10 participants will take the drug and report their fatigue levels using a simple questionnaire. The go…

This study compares two relaxation programs involving stretching and relaxation techniques to see if they improve physical and emotional well-being in women with breast cancer undergoing radiation therapy. About 681 women with early-stage breast cancer will participate, with some…

This study looks at whether a couple-based yoga program can help improve quality of life for people with high-grade glioma (a type of brain tumor) and their partners. About 216 couples will take part in Hatha yoga sessions while the patient undergoes radiation therapy. The goal i…

This study is testing a supportive care program designed specifically for Black patients with advanced cancer. The program uses meditation and mind-body techniques adapted to be culturally relevant. Researchers will work with 170 patients and their caregivers to see if this appro…

This study looks at whether adding acupuncture to standard care can reduce pain and the need for painkillers after open abdominal surgery for colorectal or pancreatic cancer. About 70 people having these surgeries will either get acupuncture or usual care. The goal is to see if a…

This study tests whether an open labeled placebo—a pill with no active medicine that patients know is a placebo—can reduce fatigue in people with advanced cancer. About 100 participants will either receive the placebo or be placed on a waitlist. The goal is to see if simply takin…

This study looks at whether teaching cancer survivors with mild to moderate heart failure about exercise and diet can help them change their lifestyle and feel better. About 85 people will take part. The main goal is to see if people stick with the program, not to cure the condit…

This study looks at whether a yoga program can improve physical performance, quality of life, and reduce symptoms like fatigue and distress in cancer patients undergoing radiation therapy, as well as their partners. About 600 patients with lung, head and neck, or esophageal cance…

This study looks at whether cancer patients can use a self-guided meditation program at home to reduce anxiety and depression. About 35 patients will try techniques like deep breathing or gentle movement for two weeks. The goal is to see if this simple, low-cost approach is pract…

This study compares a 3-week radiation schedule to the standard 5-week schedule for women with invasive breast cancer who need radiation to the lymph nodes near the breast. The goal is to see if the shorter treatment works just as well to prevent cancer from coming back, while al…

This study looked at whether ginseng can help control fatigue and related symptoms like depression and anxiety in 165 adults with advanced solid tumors. Participants rated their fatigue levels before and after taking ginseng or a placebo for 29 days. The goal was to see if ginsen…

This study compares two radiation treatments for people whose non-melanoma cancer has spread to the brain with 4 to 15 tumors. One method, stereotactic radiosurgery, delivers a high dose only to the tumors, while the other treats the whole brain. The goal is to see which better c…

This study tests if a non-invasive treatment called repetitive transcranial magnetic stimulation (rTMS) can reduce nerve pain caused by oxaliplatin chemotherapy in people with stage I-IV cancer. rTMS uses magnetic pulses on the scalp to change brain activity. The trial includes 5…

This study looks at whether giving the painkiller hydromorphone slowly or quickly through an IV affects how well it controls cancer pain and how likely it is to be misused. About 84 hospitalized cancer patients with moderate to severe pain will receive both a slow and a fast infu…

This study looks at whether cognitive behavioral therapy (CBT) can help adults with acute myeloid leukemia or lymphoma who feel very tired from their cancer or treatment. Participants will attend up to 7 counseling sessions to learn skills to cope with fatigue, anxiety, and depre…

This study tests a program called Watchful Living for Black and Hispanic men with early-stage prostate cancer and their partners. The program includes coaching and nutrition sessions to improve quality of life, physical activity, and diet. The goal is to see if this approach help…

This study tests whether a yoga-based program designed for Black adults can help them sit less, move more, and feel better emotionally. About 251 participants who are not very active and sit for long hours will take part. The program is adapted to fit their culture and will be co…

This study tested whether dexamethasone, a steroid, can reduce common symptoms like fatigue, pain, nausea, and poor appetite in people with advanced cancer. About 132 adults with at least three moderate-to-severe symptoms took part. Researchers measured changes in fatigue and oth…

This study is testing a smartphone app designed to help people reduce or quit smoking. Participants use the app along with nicotine patches to see if the combination works. The study involves 56 adults who smoke at least 10 cigarettes a day. Researchers will collect feedback on h…

This small pilot study tests whether a closed loop spinal cord stimulator can reduce pain and improve quality of life for people with nerve damage caused by chemotherapy. Ten adults with chemotherapy-induced peripheral neuropathy in their legs will receive the device and be monit…

This small pilot study tests whether using a mobile app can help adults quit smoking. About 24 smokers from MD Anderson's Tobacco Treatment Program will use either a positive psychology app or a relaxation app alongside their usual care. The main goal is to see how well people st…

This study looks at whether weighted blankets can improve sleep in adults with blood cancers. Twenty participants will use the blankets, and researchers will track any side effects and changes in sleep quality. The goal is to see if this simple, non-drug approach is safe and help…

This study tests whether combining a stimulant drug (methylphenidate) with an exercise program can reduce severe fatigue in prostate cancer patients undergoing radiation and hormone therapy. About 200 participants will be assigned to drug plus exercise, drug alone, exercise alone…

This study looks at whether exercise and weight management can help reduce fatigue in people who have had chronic lymphocytic leukemia (CLL). About 30 adults aged 18-85 with CLL will take part. Participants will be randomly assigned to start the program right away or after a wait…

This study tests a precise type of radiation (proton beam) for women with early-stage breast cancer (stage 0 to II). The goal is to see if it keeps the breast looking good and causes fewer side effects than standard radiation. About 200 women will receive the treatment and be fol…

This study tests whether a medication called methylphenidate, combined with physical activity, can reduce severe fatigue in people with advanced cancer who are receiving immunotherapy. About 212 participants will be randomly assigned to receive either the drug or a placebo, plus …

This small pilot study tests whether a vibrating device placed on certain muscles can improve walking in young people (ages 6-39) who have nerve damage from chemotherapy. The study involves 15 participants and measures changes in step timing. The goal is to ease walking difficult…

This study looks at whether massage therapy can reduce nerve problems like pain, numbness, and tingling caused by chemotherapy in people with breast or digestive system cancers. About 90 participants will receive massage sessions to see if it improves symptoms and quality of life…

This study tests a treatment called neuromodulation to see if it can reduce nerve pain caused by chemotherapy. About 24 adults with nerve pain in their legs from certain chemo drugs will take part. Researchers will check for side effects and measure changes in pain and nerve func…

This study tests whether mirtazapine, a medication often used for depression, can improve appetite and reduce weight loss in people with advanced cancer. About 98 participants will receive either mirtazapine or a placebo for 29 days. Researchers will also check if it helps with s…

This study looks at whether starting a stress-reduction program before chemotherapy can improve mood, stress, and physical symptoms in women newly diagnosed with breast cancer. About 62 women with stage I-III breast cancer will take part. Researchers will track changes in symptom…

This study tests whether neurofeedback training—a non-invasive therapy that uses brain wave monitoring—can help people with chemotherapy-induced peripheral neuropathy (nerve pain, numbness, or tingling) learn to change their own brain activity to feel less pain and improve qualit…

This study compares a single session of palliative radiation therapy to the standard multiple sessions for people with gynecologic cancers that have spread. The goal is to see if one treatment can improve symptoms like pain and bleeding and boost quality of life just as well. Abo…

This study looks at whether a culturally tailored writing program can improve the well-being of Chinese immigrant women who had breast cancer (stages 0 to III). About 256 women who finished their main cancer treatment in the last 5 years will write about their experiences. The go…

This study tests whether coaching people with breast cancer on diaphragmatic breathing helps them take larger, more consistent breaths and feel less anxious during radiation therapy. About 40 adults with left-sided breast cancer or any breast cancer needing lymph node radiation w…

This study tests whether a supervised exercise program done via video calls during chemotherapy can improve outcomes for people with pancreatic cancer. About 58 patients who are scheduled for chemotherapy and then surgery will take part. The main goal is to see if the program is …

This early-phase study tests whether a liver cancer treatment called Y90 radioembolization can be safely done in a single session instead of the usual two-day process. The treatment uses tiny radioactive beads injected into the liver's blood supply to block tumor growth. Research…

This study tests if fast-acting opioids (fentanyl or morphine) can reduce shortness of breath during or after walking in 150 cancer patients who already take strong painkillers. Participants will take the drug or a placebo before a short walk test, and researchers will measure ch…

This study tests whether a special software (Morfeus) can help doctors more accurately confirm that liver tumors are fully destroyed during a procedure called ablation. About 107 people with liver tumors will be in the study. The software analyzes CT scans to guide the doctor, ai…

This study looks at diet, exercise, mood, and social support in women who have lived with ovarian cancer for at least seven years. Researchers want to understand what factors may help these long-term survivors. The study does not provide any treatment—it only collects information…

This study surveys over 1,200 cancer patients who previously took part in behavioral trials to learn how the COVID-19 pandemic impacted their quality of life, mental health, and daily routines. Participants fill out questionnaires about stress, sleep, diet, exercise, and social s…

This study aimed to see if a shorter, less expensive MRI scan (using only two types of images) could find prostate cancer as well as the standard longer scan. It was designed for men with confirmed prostate cancer who were planning surgery. However, the study was withdrawn before…

This study looks at whether a special health check-up for older adults (called a geriatric assessment) can help them and their caregivers talk more effectively with their doctors about age-related concerns. About 479 older cancer patients and their caregivers are taking part. The…

This study looks at how different breast cancer treatment decisions, like choosing between a lumpectomy or mastectomy, affect women's quality of life and emotional distress. Researchers followed 345 women with early-stage breast cancer and their partners to measure cancer-related…

This study aims to learn how patients feel about their decision to have groin lymph node surgery for penile cancer. Researchers will ask 20 adults who had the surgery at least 6 months ago to fill out questionnaires about regret and needs. The goal is to improve care and support …

This study looks at whether additional MRI scans and blood biomarker tests can help predict how head and neck tumors change during radiation therapy. Up to 100 people (80 with cancer and 20 healthy volunteers) will take part. The goal is to gather information, not to test a new t…

This study tests a decision-aid website that helps women with cancer understand their options for preserving fertility before starting treatment. About 130 women with breast, colorectal, or reproductive system cancers, lymphoma, or myeloma took part. The goal is to see if the web…

This study uses a brain wave test (EEG) to check if cancer patients who seem unresponsive in their last days can still hear or feel. Researchers will measure brain activity when sounds or words are played. The goal is to help families and doctors understand what patients may expe…

This study looks at what happens when older smokers (ages 50-80) who are at high risk for lung cancer switch from regular cigarettes to e-cigarettes. Researchers will track how many cigarettes they smoke and measure health markers like inflammation in their blood. The goal is to …

This study gathers feedback from 260 breast cancer patients who had lymph nodes removed. Researchers want to know how patients feel about using a perometer (a device that measures arm size) to screen for lymphedema, a common side effect causing arm swelling and pain. The goal is …

This study surveys 117 advanced cancer patients about whether they have discussed with family how to manage their social media accounts after death. The goal is to understand patient needs and reduce anxiety around digital legacy. Participants are adults with advanced cancer who …

This study looks at whether men with intermediate-risk prostate cancer can follow a Mediterranean diet before their surgery. Researchers want to see if this diet change is practical and well-tolerated. The goal is to gather information on how diet might affect health and cancer o…

This study looks at whether doing MRI scans in the same position used for radiation treatment can help doctors plan spinal radiation more accurately. About 21 adults with cancer that has spread to the spine will have two MRI scans—one with a special immobilization device and one …

This study uses surveys to understand how patients and doctors feel about using telemedicine (video visits) for radiation oncology care. About 200 adults who have had at least one telemedicine visit will share their satisfaction. The goal is to learn what works and what can be im…

This study looks at how cancer patients feel about receiving hospital-level care at home through the Care and Monitoring at Home program at MD Anderson. Researchers will ask about 40 patients about their quality of life to learn what works and what could be better. The goal is to…

This study looks at whether a genetic test on tumor samples can predict how well HER2-negative breast cancer will respond to standard treatments like chemotherapy or hormone therapy. About 1,100 people with stage I-III breast cancer are taking part. The goal is to see if this tes…

This study looks at whether the bacteria in your gut and what you eat can change how well your body responds to the flu vaccine. Researchers will collect stool and blood samples from 74 adults before and after they get their flu shot. The goal is to learn, not to test a new treat…

This study looks at how different treatments for recurrent rectal cancer affect patients' well-being and quality of life. About 116 people with rectal cancer that has come back in the pelvis will answer surveys every 6 months. The goal is to understand the link between treatment …

This study looks at why some adults with advanced cancer are afraid to take opioids for pain, even when prescribed. Researchers will survey 50 patients to understand how fear, anxiety, and depression affect pain relief and medication use. The goal is to learn more about these bar…

This study looks at genetic markers that may increase the risk of developing colorectal cancer at a young age (18-50). Researchers will compare data from 818 patients and their family members to find patterns in genes, treatments, and outcomes. The goal is to better identify who …

This study tests whether a special type of CT scan (DCE-CT) can help doctors see if targeted therapy drugs for advanced kidney cancer are working. About 120 adults with metastatic renal cell carcinoma will get these scans before and shortly after starting treatment. The goal is t…

This study looked at how smokers with different reading skills respond to various health messages about smoking risks. About 500 smokers listened to and read messages that were either fact-based or emotional, and either focused on the benefits of quitting or the harms of continui…

This study looks at whether a special video mentoring program (called ECHO) can help diagnostic imaging doctors feel more connected and work more efficiently. About 36 doctors from MD Anderson will take part in regular online team meetings. The goal is to see if this approach imp…

This study is creating a simple educational tool to help people understand and decide whether to take a new blood test that can screen for many types of cancer at once. About 150 adults without a history of cancer (except certain skin cancers) will take part. The goal is to suppo…

This study is creating a web-based program to help people with hereditary cancer mutations share their genetic test results with family members. The goal is to increase awareness among at-risk relatives so they can take steps to prevent cancer. The program is designed for patient…

This study looks at how well a symptom questionnaire works for teenagers aged 13-17 who have cancer. Researchers will interview teens to see if the survey is easy to use and accurately captures their symptoms. The goal is to improve the questionnaire so doctors can better underst…

This study looks at whether having naturally low testosterone levels might increase the risk of dementia, depression, or anxiety. Researchers will analyze genetic data from large biobanks to see if there is a cause-and-effect link. No treatments or medications are given—this is p…

This study looks at whether eating more fiber can change the bacteria in your gut and help your body respond better to the flu vaccine. Researchers will ask 31 adults to follow a special diet before getting their flu shot. They will check if people can stick to the diet and measu…

This study looks at whether a special type of breast scan, called molecular breast imaging, can help doctors predict how well chemotherapy is working in women with invasive breast cancer. About 96 women will get the scan before, during, and after treatment. The goal is to see if …

This early-phase study looks at how the immune system responds to leukemia tumors after low-dose radiation given as part of standard care. Ten adults with new or recurrent myeloid leukemia will have their immune responses measured. The goal is to learn whether adding immunotherap…

This study looks at how serious money problems are for people with advanced cancer. Researchers want to understand how high costs and debt affect patients' symptoms and daily life. About 141 participants will fill out a short survey about their financial well-being.

This study looks at whether watching an online genetics video, with or without phone counseling from a genetic counselor, can reduce the stress women feel about their cancer risk. It involves 5,200 women aged 30 or older who have had triple-negative breast cancer and still have a…

This study offers lung cancer screenings to smokers who want to quit. All participants receive smoking cessation counseling, and some may also get FDA-approved quit-smoking drugs. The goal is to see which type of counseling works best to help people stop smoking. About 630 to 126…

This study looks at whether it's possible for people with a new brain tumor (glioma) to track their daily steps using a Fitbit or pedometer while undergoing radiation therapy. The goal is to see if monitoring physical activity can help improve quality of life and ease symptoms. A…

This study looks at tiny cancer cells and DNA pieces floating in the blood of people with rectal cancer. Researchers want to see if these blood markers can tell us how the tumor responds to standard treatment. The study includes about 341 people with rectal cancer and healthy vol…

This study tracks 125 head and neck cancer patients after surgery to see how many develop long-term opioid use and what factors might increase that risk. Researchers will use questionnaires to measure pain, opioid misuse risk, and symptom burden. The goal is to better understand …

This early-phase trial studies how the drug adavosertib affects tumor DNA in 38 patients with advanced ovarian, fallopian tube, or primary peritoneal cancer before they undergo surgery. The goal is to learn how the drug changes cancer cell DNA and proteins, which may help doctors…

This study looks at how quickly a commercial genomic test (MF Portrait) can provide results for people with diffuse large B-cell lymphoma. Researchers want to see if test results are available within 7 days to help guide treatment decisions. The study involves 111 adults and is l…

This study surveys parents of children with cancer to learn about their attitudes and beliefs regarding the risks of using opioids for pain. Pain is common in pediatric cancer, and opioids are a key treatment, but parents often hesitate or underuse them. The goal is to fill a kno…

This study tests a computer app that shows personalized images of what breast reconstruction might look like after surgery. The goal is to help patients make more informed decisions and reduce confusion. About 35 adults planning mastectomy and immediate reconstruction at MD Ander…

This study measures how often cancer patients experience cachexia (unintentional weight loss and loss of appetite) and the emotional burden on both patients and their primary caregivers. Researchers will track 192 patients and their caregivers at an outpatient supportive care cli…

This study looks at whether chemotherapy slows tumor growth in people with a rare type of appendiceal cancer that has spread. About 30 participants will be observed with and without chemotherapy to compare tumor growth rates. The goal is to give doctors clearer guidance on whethe…

This study tests whether a special catheter (TriNav) helps deliver radiation more accurately to liver tumors. About 19 adults with liver cancer that cannot be removed by surgery will receive a test dose followed by the actual treatment. The goal is to see if the two doses match b…

This study looks at whether giving patients with advanced cancer a special question sheet helps them communicate better with their doctors. About 207 patients and their caregivers will try one of two information sheets. The goal is to see which sheet makes it easier for patients …

This study tests a lifestyle program for African American men who have finished prostate cancer treatment and their spouses or partners. The goal is to see if the program can improve quality of life, diet, physical activity, and partner support. Only 6 participants were enrolled,…

This study looks at how day-to-day stress, social support, and healthy habits like exercise and diet affect Black prostate cancer survivors and their partners. About 200 couples will use a smartphone app to report their activities and feelings throughout the day. The goal is to u…

This early-phase pilot study tested whether adding zoledronic acid to standard chemotherapy (paclitaxel and bevacizumab) could change immune cells called macrophages in women with platinum-resistant ovarian, fallopian tube, or primary peritoneal cancer. Only 14 women who had alre…

This study looks at whether certain genetic changes in tumors can help doctors know which patients with advanced bladder cancer will benefit from the immunotherapy drug nivolumab. Researchers are testing tumor samples for specific gene mutations and a protein called CXCL13. The g…

This study looks at symptoms reported by patients with oropharyngeal (throat) cancer after they finish radiation or chemoradiation therapy. Researchers want to learn which symptoms matter most to patients, so they can improve follow-up care. About 77 adults are taking part, all t…

This study looks at whether short educational videos can help people with inherited cancer gene mutations learn more about their condition. About 43 adults who carry mutations in genes like BRCA1 or BRCA2 will watch the videos and then take a quiz. The goal is to see if this simp…

This study looks at how financial stress (called financial toxicity) affects people recently diagnosed with cancer. Researchers will survey 625 English- or Spanish-speaking adults to understand what social, behavioral, and knowledge factors contribute to financial hardship. The g…

This study looks at whether a non-invasive brain-mapping tool called nTMS can help doctors plan radiation more safely for people with brain tumors near the movement-control area. About 22 adults who already had radiation for such tumors will be tested. The goal is to see if nTMS …

This study tests a new program to help head and neck cancer patients who feel depressed. The goal is to see if the program is practical and liked by patients, and if it improves their mood and helps them follow through with swallowing exercises and dental care. About 185 adults w…

This study tests whether reminder messages can encourage adults aged 40 to 80 who smoke or used to smoke to get screened for lung cancer. Researchers will ask participants how acceptable they find these reminders. The goal is to learn if this approach can help more people get scr…

This study looks at pelvic floor problems and quality of life in people who survived uterine cancer. Researchers will use questionnaires to gather information from about 310 survivors treated with surgery at MD Anderson between 2006 and 2017. The goal is to better understand how …

This study looks at whether special imaging scans (DCE-MRI and MBI) can predict how well chemotherapy works in people with triple negative breast cancer. About 96 participants will get these scans before, during, and after chemo to see if the scans can tell who is responding. The…

This study looks at the side effects of giving a second round of radiation to people whose brain tumors have come back after earlier radiation. The goal is to find the safest dose and method to kill tumor cells while limiting damage to healthy brain tissue. About 40 adults with r…

This study is testing whether a special MRI contrast agent, called hyperpolarized 13-C pyruvate, can help doctors see how aggressive ovarian cancer is. About 30 women at high risk for ovarian cancer will be scanned. The goal is to improve early detection, not to treat the disease…

This study is building a database of health information from 1,500 people with multiple endocrine neoplasia (MEN1 or MEN2) and their close relatives. Participants fill out health questionnaires to help researchers learn more about these rare genetic conditions. The goal is to gat…

This study tests whether a less invasive ultrasound-guided biopsy can accurately tell if breast cancer has been completely wiped out by chemotherapy, compared to standard surgery. Researchers will enroll 43 adults with triple-negative or HER2-positive breast cancer who have finis…

This study looks at how the COVID-19 pandemic impacted the quality of life of cancer patients who also have nerve pain (neuropathy). Researchers will compare patients who previously received a brain-training therapy called neurofeedback with those who did not. The goal is to lear…

This study tests a program called Harmony & Health that combines yoga with Christian spirituality. The goal is to see if it helps Black adults who are not very active get more exercise. About 100 participants will take part across multiple sites. The study focuses on whether the …

This study compares two breathing strategies used during robotic bronchoscopy to prevent atelectasis (partial lung collapse) in adults with suspicious lung nodules. About 62 participants will be randomly assigned to either the VESPA or LADS method. The goal is to see which approa…

This study is screening 1,000 HOPE clinic patients for liver fibrosis and cirrhosis using surveys, blood tests, and a special liver scan called fibroscan. The goal is to learn how to better prevent or find liver cancer early, which could improve survival. Participants must be at …

This study looks at whether eating a high-fiber diet can change the gut bacteria of people with advanced melanoma who are receiving standard immunotherapy. About 50 participants will be randomly assigned to either a high-fiber or a healthy control diet for a set period. The main …

This study looks at why some children with cancer may not get the occupational or physical therapy they need. Researchers will interview doctors, therapists, and hospital administrators to find out what helps or hinders access. The goal is to reduce unfair differences in care and…

This study uses special PET and MRI scans to measure oxygen levels, blood flow, and metabolism in high-grade glioma and cervical cancers. About 20 adults with newly diagnosed or recurrent tumors will undergo imaging before starting treatment. The goal is to better understand tumo…

This study surveys 182 high-risk patients and their caregivers to understand their attitudes and beliefs about being prescribed intranasal naloxone spray, a medication that reverses opioid overdoses. The goal is to find out what barriers exist to prescribing this life-saving spra…

This study follows women who have had pelvic exenteration—a surgery removing the lower colon, rectum, and bladder—for gynecologic cancers like cervical or endometrial cancer. Researchers compare different surgical techniques to see which lead to fewer complications and better qua…

This study was designed to test new nano-sized painkillers on nerve cells from the spinal cord of people undergoing spinal tumor surgery. The goal was to see how well these cells respond to pain signals and treatments. However, the study was withdrawn before any participants were…

This study uses questionnaires and interviews to learn what Hispanic patients and primary care doctors know and think about non-alcoholic fatty liver disease (NAFLD). It aims to uncover cultural factors that may affect diagnosis and care. No treatments or medications are tested—o…

This study looks at whether a website and a genetic family navigator can help more relatives of people with hereditary cancer get genetic testing. About 205 participants will use the online hub and work with a navigator to learn about their cancer risk. The goal is to see if this…

This study tests whether wearable devices like Fitbits and continuous glucose monitors can reliably track daily exercise in people with cancer or diabetes. About 35 adults who are not very active will wear these devices for a period of time. The goal is to see if people find them…

This study looks at whether electronic tools can effectively screen mental function in 100 patients scheduled for liver surgery. Participants will complete both a digital brain test (BrainCheck) and a traditional paper test. Researchers will compare completion rates, time, and ac…

This study looks at whether analyzing the genetic changes in a patient's tumor can help doctors pick a more effective treatment for cancer that has spread. Over 1,300 participants with metastatic cancer are randomly assigned to receive either a targeted therapy based on their tum…

This study explores whether adults at low risk for heart disease can reliably measure their own physical activity, fitness, and body size at home using simple tools like pedometers and tape measures. Researchers will compare home-collected data to standard clinic measurements. Th…

This study was designed to learn about complications in cancer patients who have a fever and low white blood cells (neutropenic fever) and might be able to receive hospital-level care at home instead of in the hospital. Researchers planned to review medical records of patients tr…

This study checks if a special scale can accurately measure muscle and fat in 50 head and neck cancer patients getting radiation therapy. The goal is to see if the scale can spot muscle loss early, helping doctors decide when to add nutrition support or a feeding tube. Participan…

This study aimed to watch how tumor DNA levels change in the blood of people with early breast cancer during and after treatment. It was designed to observe, not treat, and would have included men and women with stage I to III breast cancer. However, the study was withdrawn befor…

This study looks at how often people who have had their voice box removed (total laryngectomy) use a small device called a heat-moisture exchanger (HME) to help their lungs work better. Researchers will track 130 adults to see what personal and medical factors affect how regularl…

This study looks at why women might want to get their screening mammogram results during the same visit, instead of waiting. Researchers will survey female patients aged 30 and older at three breast imaging centers. The goal is to understand patient preferences and improve the ov…

This study looks at whether offering cervical cancer screening together with family planning services helps more women get screened. About 9,000 women aged 30-49 or those living with HIV in Mozambique will take part. The goal is to see if combining these services improves health …

This study looks at whether detailed nutritional assessments can help identify malnutrition in older adults with cancer. Researchers will follow 180 patients to see how nutrition status relates to survival over 6 months and 1 year. The goal is to improve screening and care for th…

This study asks cancer patients and their caregivers about their preference for waiting in an exam room versus a waiting room when they arrive at the clinic. The goal is to understand what makes the visit more comfortable. About 406 people with advanced cancer and their caregiver…

This study looks at whether giving breast cancer patients a 3D printed model of their breast helps them feel more confident about their surgery choices. About 20 women will either get the 3D model or standard scans. Researchers will measure how sure patients feel about their deci…

This study looks at how patients at MD Anderson Cancer Center perceive their doctor's empathy during the COVID-19 pandemic. It compares in-person visits where doctors wear protective gear (PPE) to video calls where doctors do not wear PPE. About 107 English-speaking adults will s…

This study aims to find out why some people are more likely to develop bladder cancer by looking at their genes and lifestyle choices, like smoking. Researchers will compare about 6,000 people with bladder cancer to healthy individuals. The goal is to understand how differences i…

This study gathers medical information from 450 head and neck cancer patients who received or will receive proton therapy. Researchers will analyze outcomes and side effects to help doctors improve treatment for future patients. The study does not test a new treatment but collect…

This study looks at how seizures change over time in people with low grade glioma (a type of brain tumor). Researchers want to see if seizure patterns can help detect tumor changes earlier. About 100 adults with brain tumors and a history of seizures will be followed. The goal is…

This study tests whether a group education program can help medically underserved women and racial/ethnic minorities with BRCA 1 or 2 mutations follow recommended cancer screening and risk-reducing procedures. About 30 participants will take part. The goal is to see if this appro…

This study looks at how women aged 65 and older with early-stage breast cancer make decisions about chemotherapy. Researchers will interview patients and doctors to understand what information they need. The goal is to create a simple tool that helps patients and doctors weigh th…

This study looks at why some people who have had cancer surgery are afraid to take the painkillers (opioids) their doctor prescribes. Researchers will talk to 50 adults about their concerns and barriers. The goal is to better understand these fears so doctors can help patients ma…

This study tests whether a special PET scan called 18F-FSPG can help doctors see how well chemotherapy and radiation are working in patients with esophageal cancer. Nine adults with untreated, locally advanced esophageal cancer will receive the scan before and during treatment. T…

This study surveys 100 cancer patients at a pain clinic to learn how they use cannabis and CBD, how often, and why. The goal is to understand patient habits and where they get information, not to test a treatment. Results will help guide future research and education.

This study aimed to test new drug combinations for people with pancreatic cancer that could be removed by surgery or had spread locally. It was designed to compare standard chemotherapy with experimental treatments. However, the study was withdrawn before any participants were en…

This study surveys women aged 18-45 who have had gynecological or breast cancer to learn how they think about having children after treatment. Researchers will use the survey results to better understand fertility concerns and help future patients make informed decisions about ca…

This study looks at why some African American women don't exercise often and tests a program where women learn to support each other's exercise habits. About 80 sedentary African American women aged 18-65 will take part. The goal is to see if this peer-support approach increases …

This study looks at how a single dose of antibiotics given before melanoma surgery changes the bacteria in your gut. Researchers want to see if these changes affect how well the body responds to surgery and cancer treatment. The study involves 20 adults with early-stage melanoma …

This study looks at small molecules called microRNAs in the blood of people with sepsis, a severe infection. Researchers want to see if changes in these molecules can help predict who will survive. The study includes 150 adults, some with sepsis and some without, to compare their…

This study looks at side effects and overall well-being in people who have had melanoma and are now getting immunotherapy to prevent the cancer from coming back. Researchers will track side effects and ask participants about their quality of life, depression, and fatigue for up t…

This study looks at whether improving sleep can help overweight or obese African American adults who don't get enough exercise become more active. About 28 people will try a sleep program either before or after a physical activity program. The goal is to see if this approach is p…

This study was designed to understand sleep disturbances in adults with gastrointestinal cancers before and after surgery. Participants would have filled out a daily sleep questionnaire and worn a FitBit while in the hospital. However, the study was withdrawn before enrolling any…

This pilot study looks at whether adding physical activity to a quit-smoking program helps African American adults stop smoking. About 45 participants will try an exercise-based approach during their quit attempt. The main goal is to see if the program is practical and to underst…

This study looks at whether cancer patients and their doctors have similar expectations about how well patients will move and care for themselves after short-term inpatient rehabilitation. About 133 adults with cancer who can handle 3 hours of rehab daily are taking part. The goa…

This study looks at whether molecular testing can help predict the risk of endometrial cancer returning in patients with low-risk cancer who are scheduled for surgery. Researchers will also check if mapping lymph nodes can show whether the cancer has spread. The goal is to better…

This study looks at how the COVID-19 pandemic impacted the well-being and quality of life of over 13,000 cancer patients and survivors. Researchers used questionnaires to gather information on experiences like exposure, isolation, and financial disruptions. The goal is to underst…

This study looks at skin and soft tissue removed during breast implant surgery after mastectomy. Researchers want to see if the physical properties of the tissue can help predict complications like implant loss. The goal is to better understand risks and improve surgical outcomes…

This study tests whether a special imaging system (Lumicell) and 3D mammogram views can help surgeons see leftover cancer during breast-conserving surgery. The goal is to remove all cancer in one operation and avoid a second surgery. About 175 women with breast cancer will take p…