M.d. Anderson Cancer Center

This study compares two radiation treatments for people whose cancer has spread to the brain (non-melanoma). One method, stereotactic radiosurgery, delivers a strong, focused beam to each tumor. The other, whole brain radiation, treats the entire brain with lower doses over sever…

This study tests whether special immune cells called veto cells can help donor stem cells grow in patients with blood cancers after a transplant, without causing severe graft-versus-host disease (GVHD). About 16 patients aged 12-75 will receive these cells alongside standard chem…

This study tests a combination of two drugs—SX-682 and nivolumab—in people with a specific type of advanced colorectal cancer that has spread or cannot be removed. The cancer must have a RAS mutation and be microsatellite stable (MSS), which often makes it harder to treat. The go…

This study tests a drug called acalabrutinib in people with mantle cell lymphoma who had severe side effects from the similar drug ibrutinib. The goal is to see if acalabrutinib can still shrink or control the cancer without causing the same intolerable side effects. Nine partici…

This study looks at whether a precise type of radiation, called stereotactic radiosurgery, can prevent brain tumors from coming back after surgery. About 132 people with up to 3 brain metastases will either receive this radiation or be watched closely. The goal is to see if the r…

This early-stage study tests a drug called NBTXR3 that makes radiation more effective at killing lung cancer cells. It is for people whose lung cancer has returned after previous radiation and cannot be removed with surgery. The goal is to find the safest dose and see if it can h…

This early-stage trial tested the safety and best dose of three drugs—daratumumab, ixazomib, and dexamethasone—in 21 people with AL amyloidosis, a rare disease where abnormal proteins build up in organs. The goal was to find the safest combination to stop the growth of harmful ce…

This early-phase study tested a new approach for people with advanced melanoma that has spread. Doctors took immune cells (T-cells) from patients, modified them in the lab to resist a tumor-blocking signal (TGF-beta), and returned them along with a drug (IL-2) to boost their acti…

This study tests a drug called talazoparib in people with advanced cancers that have not responded to standard treatments. The drug works by blocking an enzyme that helps cancer cells survive, especially in tumors with changes in BRCA or related genes. The goal is to see if the d…

This study tests whether giving the drug selpercatinib before surgery can shrink thyroid cancers with a specific genetic change (RET alteration). About 30 people with advanced or recurrent thyroid cancer will receive the drug and then have surgery. The goal is to see if the drug …

This study tests whether using MRI scans to plan radiation therapy can safely lower the dose for people with low-risk HPV-positive throat cancer. The goal is to keep the cancer under control while reducing swallowing problems and the need for feeding tubes. About 90 adults with e…

This study tests a combination of two drugs, ibrutinib and rituximab, in people with mantle cell lymphoma that has returned or not responded to treatment, as well as in older patients newly diagnosed with the disease. The goal is to see how well the drugs work together to shrink …

This early-phase study tests a combination of two immunotherapy drugs (tiragolumab and atezolizumab) plus a special type of radiation (RadScopal) in people with advanced solid tumors that have spread. The main goal is to check safety and side effects. Only 7 participants are enro…

This study tests a combination of two drugs, zanubrutinib and rituximab, in 60 adults with untreated chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma. The goal is to see if the combo can control the disease and allow patients to stop treatment for at least 6 month…

This study tests whether adding an immunotherapy drug (nivolumab) to precise, high-dose radiation (SABR) can better prevent lung cancer from coming back or spreading, compared to radiation alone. About 140 adults with early-stage non-small cell lung cancer or a single recurrence …

This early-stage trial tests a new treatment called IVS-3001, which uses a patient's own immune cells (CAR-T cells) that are modified to recognize and attack a protein called HLA-G found on some solid tumors. The study includes 31 adults with advanced solid tumors that have not r…

This early-stage study tests whether injecting the immunotherapy drug nivolumab directly into high-risk oral premalignant lesions (abnormal spots in the mouth that could become cancer) is safe and can shrink or eliminate them. 18 adults with such lesions are receiving the injecti…

This study compares radiation therapy alone to radiation combined with rituximab (a drug that helps the immune system attack cancer) in people with early-stage (I or II) follicular lymphoma. The goal is to see if adding rituximab keeps the cancer from growing or coming back longe…

This study tests a combination of two chemotherapy drugs (gemcitabine and docetaxel) plus hydroxychloroquine, a drug usually used for malaria, in people whose osteosarcoma has returned or stopped responding to standard treatments. The goal is to find the safest dose of hydroxychl…

This study tested a treatment that combines two chemotherapy drugs (cisplatin and docetaxel) with an immunotherapy drug (pembrolizumab) in 28 patients with stage II or III laryngeal cancer. The goal was to see if this approach could control the cancer and allow patients to keep t…

This study looks at whether an integrative oncology program—including diet advice, physical activity, stress management, and social support—can improve cancer-related outcomes and quality of life in women with stage II or III breast cancer who are receiving radiation therapy. Abo…

This study tests a combination of three chemotherapy drugs (docetaxel, cisplatin, and fluorouracil) as a first treatment for people with advanced nasal cavity or sinus cancer that hasn't spread to other parts of the body. The goal is to shrink tumors enough to avoid or reduce the…

This study tests a combination of three drugs (acalabrutinib, lenalidomide, and rituximab) in 60 people with untreated stage III-IV follicular lymphoma. The goal is to see if the combination can shrink or eliminate tumors and keep the disease under control. Participants must have…

This study tests a powerful chemotherapy regimen (Hyper-CVAD) combined with the targeted drug ponatinib in people with a specific type of acute lymphoblastic leukemia (ALL) that has a genetic change called the Philadelphia chromosome. The goal is to see if this combination can ke…

This early-phase study tests whether a new cell therapy called KSQ-001EX is safe for people with advanced solid tumors, including melanoma, lung cancer, and head & neck cancers. The treatment uses a patient's own immune cells (tumor-infiltrating lymphocytes) that are genetically …

This study tests whether a shorter, higher-dose radiation schedule (hypofractionated) works as well as the standard longer schedule for men with prostate cancer who have had surgery. About 186 men will take part. The goal is to see if the shorter treatment causes fewer side effec…

This study aimed to see if the drug glofitamab could stop large B-cell lymphoma from coming back in patients who were in remission but still had tiny traces of cancer (minimal residual disease). The trial was withdrawn before enrolling any participants, so no results are availabl…

This study was designed to test a combination of two drugs, regorafenib and lorigerlimab, in people whose rectal cancer had come back or was growing after initial treatment. The goal was to see if the combination was safe and effective. However, the trial was withdrawn before any…

This study tests whether combining two drugs, dasatinib and venetoclax, can better control early chronic phase chronic myeloid leukemia (CML). About 155 adults with newly diagnosed CML (within 12 months) who have had little or no prior treatment are participating. The goal is to …

This study was designed to test a combination of two drugs (regorafenib and lorigerlimab) given before surgery to people with a certain type of colorectal cancer that had spread only to the lungs. The goal was to see if the treatment was safe and could help shrink tumors. However…

This study tests whether adding targeted radiation to standard drug therapy can better control cancer that has spread to a few places in the body (oligometastatic disease). About 380 adults with solid tumors and up to 5 metastatic spots will be randomly assigned to receive either…

This study tests whether adding elotuzumab to standard lenalidomide maintenance therapy can help keep multiple myeloma from returning after a stem cell transplant. About 113 people who recently had a transplant using their own stem cells will receive the drug combination. The goa…

This study tests whether adding the immunotherapy drug atezolizumab to standard chemotherapy helps people with advanced anaplastic or poorly differentiated thyroid cancer live longer. About 50 adults with cancer that cannot be removed by surgery or has spread will receive differe…

This study tests a combination of two drugs, acalabrutinib and rituximab, in people aged 65 and older with newly diagnosed mantle cell lymphoma. The goal is to see if the combo can control the cancer while causing fewer severe side effects. About 53 participants will receive the …

This early-phase study tests a DNA vaccine made from patients' own cancer cells to help their immune system attack lymphoplasmacytic lymphoma, a rare blood cancer. Nine participants with asymptomatic disease received the vaccine to find the safest dose and check for side effects.…

This early-stage trial studies the safety of giving the immunotherapy drug pembrolizumab after radiation therapy for people with malignant pleural mesothelioma, a rare cancer of the lung lining. The study enrolled 24 adults whose cancer was confirmed by biopsy. The main goal is t…

This study tests whether giving a mix of targeted drugs before and with standard chemotherapy can better control a fast-growing lymphoma called DLBCL. About 62 adults with newly diagnosed disease will receive the combination. The goal is to see if more patients achieve complete r…

This study tests a combination of three drugs (ixazomib, gemcitabine, and doxorubicin) in people with advanced bladder cancer that has spread or cannot be removed by surgery. The goal is to find the safest dose and see if the treatment can shrink tumors. About 57 adults will take…

This study tests whether using home devices to monitor dehydration risk can reduce hospitalizations and emergency room visits in head and neck cancer patients. About 427 participants will either use the CYCORE sensor system plus standard care, or standard care alone. The goal is …

This study tests whether the drug regorafenib can help control gastrointestinal stromal tumors (GIST) that have specific gene changes (KIT exon 17, 18, or 14, or SDHB deficiency) and have stopped responding to the first treatment, imatinib. About 3 adults with advanced GIST will …

This study tests a combination of chemotherapy (gemcitabine, nab-paclitaxel) and two immunotherapy drugs (durvalumab, oleclumab) given before surgery to people with pancreatic cancer that can be removed. The goal is to shrink the tumor and improve the body's immune response. Abou…

This study tests a combination of drugs (olaparib, durvalumab, carboplatin, etoposide) and radiation for people with extensive-stage small cell lung cancer that hasn't been treated yet. The goal is to see if this mix is safe and works better than standard care. About 63 adults wi…

This study tests whether shining special lights in the mouth can help spot early signs of oral cancer. About 338 people at higher risk for mouth cancer (such as those with white or red patches, heavy tobacco use, or certain conditions) will have their mouth tissues examined with …

This study tests a special mammogram that uses a dye injected into the blood to make breast tissue and blood vessels clearer. The goal is to see if this method finds cancer better than standard mammograms in women with suspicious breast changes. About 100 women aged 25-85 who nee…

This study tests a new 3D MRI method to see if it can find prostate cancer better than standard MRI, without needing a special coil inside the body. About 33 men with untreated, intermediate- or high-risk prostate cancer will be scanned before surgery. The goal is to improve how …

This study is testing whether a special contrast agent, called hyperpolarized 13-C pyruvate, can help MRI scanners find prostate cancer more clearly. About 130 men with prostate cancer will receive this contrast before an MRI. The goal is to see if this method improves detection …

This study tests if acupuncture can prevent dry mouth in 435 head and neck cancer patients receiving radiation. Participants get one of two acupuncture approaches to see which works better. The goal is to reduce dry mouth and improve quality of life.

This study tests a program called Tu Salud Si Cuenta! that helps Latino families adopt healthier habits like eating more fruits and vegetables and being more physically active. Around 600 participants join with a family member. The goal is to see if the program leads to lasting h…

This study tests different programs to help people at high risk for cancer—such as those with BRCA or Lynch syndrome, or cancer survivors—increase their physical activity and eat healthier. The goal is to see which approach works best for reducing cancer risk. About 337 participa…

This study tests whether a drug called anamorelin, combined with physical activity and nutritional counseling, can reduce severe fatigue in people with advanced solid tumors that have spread or come back. About 129 participants will receive the combination for several weeks. The …

This study looks at whether a single session of radiation therapy can improve symptoms like pain and bleeding in women with advanced gynecologic cancer that has spread. The goal is to see if one treatment works as well as the standard multiple sessions for improving quality of li…

This study looks at whether massage therapy can reduce nerve problems caused by chemotherapy, such as pain, numbness, and tingling. About 90 people who had breast or digestive system cancer and finished chemo at least 6 months ago will receive massage sessions. The goal is to see…

This study compares two numbing medicines, EXPAREL and lidocaine, in 80 adults with malignant pleural neoplasm (a type of lung cancer). Patients receive one of the two during a procedure that takes a lung sample and places a tube to drain fluid. The goal is to see which medicine …

This study compares two relaxation programs (including stretching and relaxation techniques) to see if they improve physical and emotional well-being in women with breast cancer undergoing radiation therapy. About 681 women with early-stage breast cancer will participate. Some wi…

This study tests whether a meditation-based mind-body program can improve quality of life for adolescents and young adults (ages 18-39) recently diagnosed with lymphoma. Participants learn meditation techniques to help lower distress, anxiety, and depressive symptoms. The goal is…

This study looks at whether exercise and weight management can help reduce fatigue in people who have chronic lymphocytic leukemia (CLL). About 30 adults aged 18-85 with CLL will take part. Participants will be randomly assigned to start the program right away or after a waiting …

This study looks at a fast way to find depression in women with ovarian, peritoneal, or fallopian tube cancer. It compares a special support program to regular care to see which helps improve quality of life more. About 409 women on active treatment take part. The goal is to bett…

This study tests a procedure called cordotomy, where a needle is guided by CT scans to the spinal cord to reduce severe pain in people with advanced cancer. The goal is to see if it can lower pain that hasn't been controlled by other treatments. The study involves 27 adults with …

This study looks at whether teaching cancer survivors who have heart failure about exercise and diet can help them change their lifestyle. About 85 people with mild to moderate heart failure that got worse after chemotherapy will take part. The goal is to see if they can stick wi…

This study tests whether adding exercise, supportive counseling, and a stimulant drug (methylphenidate) can reduce severe fatigue in prostate cancer patients receiving radiation and hormone therapy. 175 participants will try different combinations of these treatments. The goal is…

This study looks at how different treatments for recurrent rectal cancer impact patients' quality of life and well-being. About 116 participants with cancer that has returned in the pelvis will fill out surveys over time. The goal is to understand the relationship between treatme…

This study aims to create an educational guide to help people understand and decide about Multi-Cancer Early Detection (MCED) blood tests. About 150 adults without a cancer history will take part. The goal is to support informed decision-making, not to test the blood test itself.

This study looks at how day-to-day stress, social support, and healthy habits like exercise and diet affect Black prostate cancer survivors and their partners. About 200 couples will use a smartphone app to report their feelings and activities throughout the day. The goal is to u…

This study looks at whether a commercial genetic test, called the Molecular Functional Portrait, can quickly provide useful information for treating lymphoma. About 111 adults with a type of lymphoma called diffuse large B-cell lymphoma will take part. The main goal is to see if …

This study compares two breathing strategies used during robotic bronchoscopy (a lung biopsy procedure) to see which one better prevents atelectasis (partial lung collapse). About 62 adults with suspicious lung nodules will take part. The goal is to find the safer, more effective…

This early-phase study tests whether adding zoledronic acid to standard chemotherapy and a targeted therapy can help women with ovarian cancer that has stopped responding to platinum-based treatment. The main goal is to see how the drug combo affects immune cells called macrophag…

This study surveys 100 cancer patients at a pain clinic to learn how they use cannabis and CBD, how often, and why. The goal is to understand patient habits and where they get information, not to test a treatment. Results may help guide future research and education.

This study looks at whether a lifestyle program can help African American prostate cancer survivors and their partners improve quality of life, diet, and physical activity. About 6 survivors with early-stage prostate cancer and their spouses or romantic partners will take part. T…

This study looks at how a single dose of antibiotics given before melanoma surgery changes the bacteria in your gut. Researchers want to see if these changes might affect how well the body responds to surgery. The trial involves 20 adults with early-stage melanoma who are having …

This study uses EEG (brain wave testing) to find out if patients in their final days of life who appear unresponsive can still hear or feel. Researchers will measure brain activity when sounds or words are played. The goal is to help families and doctors better understand what dy…

This study tests whether a less invasive ultrasound-guided needle biopsy can accurately tell if breast cancer has been completely eliminated by chemotherapy, compared to standard surgery. About 43 women with aggressive breast cancer types (triple negative or HER2-positive) who ha…