Immunotherapy shot targets Pre-Cancer mouth spots

NCT ID NCT05327270

First seen Jan 07, 2026 · Last updated Apr 25, 2026 · Updated 14 times

Summary

This early-stage study tests whether injecting the immunotherapy drug nivolumab directly into high-risk oral premalignant lesions (abnormal spots in the mouth that could become cancer) is safe and can shrink or eliminate them. 18 adults with such lesions are receiving the injections. The goal is to prevent progression to head and neck cancer.

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Contacts and locations

Locations

  • M D Anderson Cancer Center

    Houston, Texas, 77030, United States

Conditions

Explore the condition pages connected to this study.