New combo tackles tough ovarian cancer: early trial sees immune clues

NCT ID NCT05053750

First seen Nov 01, 2025 · Last updated Jun 12, 2026 · Updated 33 times

Summary

This early-phase pilot study tested whether adding zoledronic acid to standard chemotherapy (paclitaxel and bevacizumab) could change immune cells called macrophages in women with platinum-resistant ovarian, fallopian tube, or primary peritoneal cancer. Only 14 women who had already tried 1-2 other treatments for recurrence took part. The main goal was to measure immune cell counts, not to cure or control the disease directly.

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Contacts and locations

Locations

  • M D Anderson Cancer Center

    Houston, Texas, 77030, United States

Conditions

Explore the condition pages connected to this study.