M.d. Anderson Cancer Center

This early-phase trial tested a personalized vaccine made from each patient's own blood and bone marrow. The goal was to see if the vaccine is safe and can help the immune system attack cancer cells in people with smoldering multiple myeloma, a high-risk condition that often lead…

This study tested whether adding ready-made natural killer (NK) cells from a donor to a standard stem cell transplant could safely reduce the chance of cancer returning in people with high-risk myeloid cancers like acute myeloid leukemia, myelodysplastic syndrome, and chronic mye…

This early-phase trial tested a combination of three drugs (vemurafenib, cetuximab, and irinotecan) in 47 people with advanced solid tumors that have a specific BRAF V600 mutation and cannot be removed by surgery or have spread. The main goal was to find the safest dose of vemura…

This study tested a combination of three drugs (panitumumab, carboplatin, and paclitaxel) given before surgery to 43 women with a hard-to-treat type of breast cancer called triple-negative breast cancer. The goal was to see if this treatment could shrink tumors enough to reduce t…

This study tested a combination of two immunotherapy drugs (durvalumab and tremelimumab) plus a targeted therapy (selumetinib) in 40 people with advanced non-small cell lung cancer that had returned. The goal was to find the safest dose and see if the combination could shrink tum…

This study tested whether adding the targeted drug erlotinib to standard chemotherapy (docetaxel plus cisplatin or carboplatin) could improve tumor shrinkage before surgery in people with advanced head and neck cancer. About 55 adults with surgically removable tumors took part. T…

This study tested a new antibiotic combination (imipenem-relebactam) against standard antibiotics for treating fever caused by low white blood cells in 100 cancer patients. The goal was to see if the new drug works better at controlling infections. Results may help improve care f…

This study looked at whether taking daily aspirin and vitamin D, along with exercise and a low-fat diet, could help prevent colorectal cancer from returning in 16 patients who had no visible cancer but still had signs of cancer DNA in their blood. The goal was to see if these lif…

This early-phase trial tested two drugs, cabozantinib and pamiparib, in 44 adults with advanced solid tumors that had spread or stopped responding to standard treatments. The goal was to find the safest dose and understand side effects. The drugs work by blocking certain enzymes …

This study tested the drug pembrolizumab (Keytruda) in 15 people with high-risk precancerous mouth lesions. The goal was to see if the drug could prevent these lesions from turning into oral cancer. Participants were randomly assigned to receive the drug or just be watched. The s…

This early-phase trial tested a new drug called ALRN-6924 combined with the chemotherapy paclitaxel in 28 adults with advanced solid tumors that had spread or couldn't be removed by surgery, including a type of breast cancer. The main goal was to find the safest dose and check fo…

This study tested giving immunotherapy drugs (nivolumab alone or with ipilimumab) or immunotherapy plus chemotherapy before surgery for people with early-stage non-small cell lung cancer (stages I to IIIA). The goal was to see if these treatments could shrink or eliminate the tum…

This early-stage trial tested whether giving the immunotherapy drug pembrolizumab after radiation therapy is safe for people with pleural mesothelioma, a rare cancer of the lung lining. Twenty-five participants received the combination to check for severe side effects. The goal w…

This study tested a new drug called uproleselan added to standard chemotherapy for people with a specific type of leukemia (secondary AML that has been treated before). The goal was to find the best dose and see how well the combination works. 37 adults took part, and the study l…

This early-stage trial tested two drugs, vandetanib and everolimus, together in 151 people with advanced cancer that had spread or stopped responding to standard treatments. The goal was to find the safest dose and see if the combination could slow cancer growth by blocking key e…

This study tested whether adding a type of immunotherapy (pembrolizumab) to targeted radiation therapy could help control advanced non-small cell lung cancer. 124 patients with stage IV disease received the combination. The goal was to shrink tumors and delay cancer growth, not t…

This study tested a combination of three drugs (decitabine, venetoclax, and ponatinib) in 20 adults with Philadelphia chromosome-positive acute myeloid leukemia or chronic myelogenous leukemia that had worsened. The goal was to see how many patients achieved remission after two t…

This study tested whether adding radiation to an immunotherapy drug (pembrolizumab) could help people with non-Hodgkin lymphoma that returned or didn't respond to prior treatments. Seventeen adults with aggressive types of lymphoma received both treatments. The goal was to see if…

This study tested a drug called blinatumomab in 36 adults with B-cell acute lymphoblastic leukemia who were in remission but still had a small number of cancer cells (minimal residual disease). The drug helps the immune system attack these leftover cells to keep the cancer from c…

This study tested a combination of two immunotherapy drugs, low-dose ipilimumab and pembrolizumab, in 24 people with advanced melanoma that had spread to the brain. The goal was to see if the treatment could shrink or control brain tumors and improve survival. Participants receiv…

This early-phase trial tested two drugs—binimetinib and hydroxychloroquine—in 34 people with a specific type of advanced pancreatic cancer (KRAS-mutant) that had spread. The goal was to find the safest dose of hydroxychloroquine when used with binimetinib, and to see if the combi…

This study tested the drug dasatinib in 17 people with chronic lymphocytic leukemia (CLL) who had already tried other treatments. The goal was to see if the drug could shrink or control the cancer. Researchers also checked for side effects. The study did not aim to cure the disea…

This study tested the drug dasatinib in 68 adults with several types of blood and bone marrow disorders, including certain leukemias, myelofibrosis, and mastocytosis. The goal was to see if dasatinib could help control the disease and to check its safety. Participants took dasati…

This study tested a new treatment for people with CD30-positive Hodgkin or non-Hodgkin lymphomas that came back or didn't respond to standard therapy. The treatment combines a special antibody (AFM13) with immune cells called natural killer (NK) cells from donated umbilical cord …

This study tested whether combining oral azacitidine with pembrolizumab can help control advanced melanoma that has spread. It involved 24 adults whose melanoma either hadn't been treated with PD-1 drugs or had worsened after such treatment. The goal was to see how many patients'…

This early-phase trial tested a combination of two antibody drugs (utomilumab and cetuximab) plus chemotherapy (irinotecan) in 34 people with advanced colorectal cancer that had spread. The main goals were to find the safest dose and check if the treatment shrinks tumors. The stu…

This study tested a combination of chemotherapy (nab-paclitaxel) and immunotherapy (atezolizumab) given before surgery to women with triple-negative breast cancer. The goal was to shrink tumors and reduce the amount of breast tissue that needs to be removed. The trial involved 37…

This study tested a drug called guadecitabine combined with a donor white blood cell infusion for people whose acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) came back after a stem cell transplant. The goal was to see if this treatment could help control the cance…

This study tested two immunotherapy drugs, nivolumab and ipilimumab, in 29 people whose acute myeloid leukemia or myelodysplastic syndrome had come back or not responded after a donor stem cell transplant. The goal was to find the safest dose and see if the drugs could help the i…

This early-phase trial tested two experimental drug combinations in 37 people with advanced EGFR-mutant lung cancer that no longer responded to the targeted therapy osimertinib. The goal was to find safe, tolerable doses of alisertib or sapanisertib when given together with osime…

This study looked at whether giving the drug ibrutinib early to people with chronic lymphocytic leukemia (CLL) who have high-risk features but no symptoms is better than waiting until symptoms develop. 23 participants took ibrutinib for up to 24 months. The goal was to see how ma…

This study tested whether adding the immunotherapy drug atezolizumab to standard chemotherapy and radiation can help people with newly diagnosed glioblastoma, an aggressive brain cancer. About 60 participants received the combination to see if it is safe and improves survival. Th…

This study tested whether varenicline, a non-habit-forming drug, works better than nicotine patches and lozenges to help people quit smoking. Over 600 smokers participated, and the main goal was to see who could stay smoke-free for at least 7 days. The results help doctors choose…

This study tested a combination of enzalutamide (a hormone blocker) and paclitaxel (chemotherapy) given before surgery to 24 people with a specific type of triple-negative breast cancer that has androgen receptors. The goal was to see if this treatment could shrink tumors enough …

This study tested a combination of three immunotherapy drugs (BMS-986156, ipilimumab, and nivolumab) with or without precise radiation therapy in 51 people with advanced lung, chest, or liver cancer that had spread. The goal was to find the safest doses and see if the treatment h…

This study looked at whether adding a drug called axitinib to standard hormone therapy before surgery could help control prostate cancer that had spread to lymph nodes. Seventy-three men with previously untreated prostate cancer participated. The goal was to see if the combinatio…

This study tested two immunotherapy drugs, durvalumab and tremelimumab, in 100 people with ovarian, fallopian tube, or peritoneal cancer that came back or stopped responding to platinum chemotherapy. The goal was to see if giving both drugs together or one after the other works b…

This study tested a combination of two drugs, ruxolitinib and azacytidine, in 121 people with myelofibrosis or related blood cancers. The goal was to see if the combo could shrink tumors or improve blood counts. While the treatment aims to control the disease, patients may still …

This study tested the drug pegloticase in 10 cancer patients with high uric acid levels caused by tumor lysis syndrome, a complication where cancer cells break down quickly. The goal was to see if the drug could safely lower uric acid and protect kidney function. Results are not …

This study tested whether the drug dasatinib can control chronic myeloid leukemia (CML) in its early chronic phase. 150 adults with newly diagnosed CML took dasatinib, and researchers measured how many achieved a major molecular response (very low levels of cancer genes) after 12…

This early-phase study tested a combination of three chemotherapy drugs (CPX-351 and gemtuzumab ozogamicin) in children whose acute myeloid leukemia (AML) had come back or didn't respond to standard treatment. The main goals were to find the best dose and check for side effects. …

This study tested a drug called sintilimab in people with a rare cancer where doctors cannot find where the cancer started (cancer of unknown primary). The goal was to see if the drug could shrink tumors or stop them from growing. Ten patients who had already tried other treatmen…

This study tested a new formulation of two chemotherapy drugs (CPX-351) in 56 adults with newly diagnosed acute myeloid leukemia (AML) who were at high risk of not responding to standard treatment. The goal was to find the best dose and see how well it worked to stop cancer cells…

This early-phase study tested the safety and best dose of the drug olaparib when combined with high-dose chemotherapy for people with lymphomas that returned or didn't respond to treatment. The 50 participants received this combination before a stem cell transplant. The goal was …

This early-phase study tested a combination therapy in 15 people with colon cancer who had completed standard treatment but still had tiny amounts of cancer DNA in their blood (called minimal residual disease). The treatment used specially activated immune cells from donated umbi…

This early-phase trial tested the safety and best dose of the immunotherapy drug pembrolizumab when combined with chemotherapy and radiation for people with small cell lung cancer. The goal was to see if adding pembrolizumab helps the immune system fight the cancer more effective…

This study looked at whether adding a special scope test (EBUS-TBNA) after a standard PET/CT scan can more accurately stage early-stage non-small cell lung cancer. About 150 adults with stage I-IIA lung cancer who were being considered for precise radiation therapy took part. The…

This study looked at whether contrast-enhanced mammography (CEM) can find breast cancers that standard imaging might miss. 89 women with known or suspected breast cancer received CEM, which uses an iodine dye to make tumors and blood vessels stand out. The goal was to see if CEM …

This study tested whether the immunotherapy drug pembrolizumab could prevent lung cancer from coming back in 45 people with early-stage lung cancer or high-risk lung nodules. Participants received the drug and were monitored for tumor response and survival. The goal was to see if…

This study looked at whether giving an additional anesthetic nerve block after pancreatic surgery helps patients use fewer opioid painkillers. 136 adults having open pancreatic surgery for cancer were randomly assigned to receive either one nerve block or a repeat block. The main…

This study looked at whether giving a light electrical pulse to a specific spot on the wrist (called P6) during breast cancer surgery could help prevent nausea and vomiting after the operation. 188 women at high risk for post-operative nausea took part. The goal was to see if add…

This study tested whether a single, precise session of high-dose radiation (stereotactic body radiotherapy) can safely relieve pain and control tumor growth in people with cancer that has spread to the spine. 71 adults with up to two spine tumors participated. Researchers measure…

This study tested if playing an augmented reality game called SpellBound can help children with cancer feel less pain and need fewer opioids after surgery. 29 kids aged 5-15 who had never taken opioids before took part. The game was used alongside standard care to see if it impro…

This study tested whether doing simple positive activities, like helping with household chores or writing a thank-you letter, could improve quality of life for cancer patients from collectivist cultures (e.g., Latino, Asian American, African American). 75 patients and their careg…

This study tested what happens when smokers use cigarettes with very low nicotine while also having e-cigarettes with different nicotine levels. Researchers wanted to see how this affects how many cigarettes people smoke, their cravings, and withdrawal symptoms. The study include…

This study tested two new methods to measure pressure and stiffness inside solid tumors in 27 patients. One method uses a thin catheter to measure pressure directly, and the other uses sound waves like an ultrasound to check stiffness. The goal was to see if these measurements co…

This study looked at what stops Black men in faith-based communities from getting screened for prostate cancer. Researchers worked with 24 participants to gather information that will help create a prostate cancer education program designed for Black men in church settings. The g…

This study looked at 169 adult smokers to see if men and women have different experiences when switching from regular cigarettes to a standard research e-cigarette. Researchers measured how many cigarettes people smoked, how often they used the e-cigarette, and their nicotine lev…

This study looked at ways to make radiation treatment for spinal tumors more accurate. Researchers placed small markers in the body to track movement during treatment. They also tested whether giving slightly more radiation to the nearby esophagus could be safe and help control t…

This study tested two devices that help doctors place a breathing tube before surgery in 143 head and neck cancer patients with difficult airways. One device is a flexible scope, and the other combines that scope with a video laryngoscope. The goal was to see which method reduces…

This study tested a mobile app called JEEVA designed to help breast surgery patients before and up to 30 days after their operation. 60 patients used the app and rated how easy it was to use and how satisfied they were with it. The goal was to see if the app is a helpful tool for…

This study tested a tool called an oncology dashboard that shows a patient's cancer treatment information to them, their doctor, and their radiologist. The goal was to see if it helps patients understand their disease better and makes care more efficient. The study included 92 pe…

This early-phase study tested two doses of the drug erlotinib given before surgery to 48 people with head and neck cancer. The goal was to see how the drug changes certain markers in tumor tissue, not to cure the disease. Researchers compared standard and high doses to understand…

This study looked at whether adding a type of antibiotic called aminoglycosides helps cancer patients with sepsis (a severe infection) recover from dangerously low blood pressure. Researchers studied 232 adult cancer patients with sepsis. They compared those who received standard…