Arterial disorder

This trial investigates whether a procedure to remove a blood clot from the basilar artery—a major vessel at the back of the brain—can improve recovery in people with severe stroke. Participants are adults aged 18 to 80 who have a large area of brain damage and can be treated wit…

This study tests whether a nurse-led, community-based program can help lower blood pressure in adults aged 25 and older with uncontrolled hypertension in Monrovia, Liberia. Trained community health nurses provide medication and lifestyle counseling at mobile clinics in high-traff…

This pilot study tests a new catheter device designed to deliver clot-dissolving medication directly to blood clots in the lungs of adults with intermediate-risk pulmonary embolism. The goal is to see if the device can be used safely and as intended. All 20 participants will rece…

This Europe-wide study will follow 400 people with severe leg artery disease (chronic limb-threatening ischemia) to see if a new dissolvable, drug-coated scaffold can keep leg arteries open better than standard treatments. The scaffold releases medication to prevent re-blockage a…

This study will follow 250 people with chronic limb-threatening ischemia (CLTI) across Europe to see how well orbital atherectomy works in real life. The procedure uses a tiny spinning tool to gently remove hard calcium from leg arteries, making it easier for balloons or stents t…

This trial tests whether using a balloon guide catheter along with a filter can better protect the brain during carotid artery stenting. People with narrowed neck arteries (carotid stenosis) who need stenting are randomly assigned to get either the balloon-plus-filter combo or a …

This study tests whether combining two medications, empagliflozin and finerenone, can lower blood pressure in adults with obesity and stage 1 hypertension. Participants take the drugs or a placebo daily for 12 weeks. The trial also measures effects on kidney function, inflammatio…

This study tests whether using a temporary heart pump (CorVad) during a procedure to open blocked arteries (PCI) can improve outcomes for people with complex coronary artery disease and a very weak heart (ejection fraction below 35%). Half of the 452 participants will receive the…

This trial tests whether a single daily pill that combines treatments for high blood pressure, high cholesterol, and type 2 diabetes can lower the risk of heart disease and dementia. The study involves over 8,000 adults aged 50 to 75 in China who have all three conditions. Partic…

This study tests two blood-thinning strategies in people with severe aortic regurgitation who have had a new heart valve placed without open surgery. Participants receive either daily aspirin for a year or warfarin for six months followed by aspirin. The goal is to see which appr…

This study tests whether adding an 8-week online mindfulness program, called Mindfulness in Motion, to usual care helps people with high blood pressure improve their blood pressure, weight, stress, sleep, and well-being. Participants will be randomly assigned to either the mindfu…

This study tests an experimental drug called REGN22530 in people with primary open angle glaucoma or ocular hypertension. The drug is designed to block a protein in the eye that causes fluid buildup and high pressure. Researchers are checking for side effects, how the drug moves …

This trial compares a new temporary heart pump called VentriCure with standard ECMO support in people with coronary artery disease undergoing high-risk angioplasty. The study includes 220 patients whose hearts are weak or who have severe heart failure. The goal is to see if Ventr…

This phase 3 trial tests whether a new drug called HCP1803-4 can safely lower blood pressure in adults with essential hypertension. Participants are randomly assigned to receive either the new drug or a control drug. The study measures changes in sitting blood pressure over time …

This study tests the safety of a new medicine called sotatercept for adults in India with pulmonary arterial hypertension (PAH), a condition where blood vessels in the lungs become narrow, making breathing hard. About 30 people will receive sotatercept along with their usual trea…

This study tests a stent (Carotid WALLSTENT) used with a special brain protection system (ENROUTE NPS) in 60 Chinese patients with narrowed carotid arteries. The goal is to see if the combination can be safely delivered to prevent strokes. Patients must have significant artery na…

This study explores whether applying mild electrical stimulation to the spinal cord through the skin can improve blood pressure control in people with spinal cord injury. Participants will undergo tilt-table tests to measure immediate effects, plus 20 stimulation sessions to see …

This phase 3 trial tests whether a new emergency stroke unit, equipped with a hybrid CT and X-ray machine (NeuAngio-CT), can speed up clot removal in people having a severe stroke. About 232 adults aged 18-60 with acute ischemic stroke will be randomly assigned to either the new …

This early-stage study tests whether it is safe to take nitroglycerin spray (used for chest pain) together with an experimental drug called nurandociguat (designed to help kidneys) in 36 adults with stable coronary artery disease. Both drugs widen blood vessels, so the main conce…

This trial tests whether a newer anesthetic drug, ciprofol, causes fewer dangerous drops in blood pressure during anesthesia than the standard drug propofol in frail patients aged 60 and older having major abdominal surgery. Participants are randomly assigned to receive one of th…

This study tests a 6-month program where patients work with a pharmacist and their primary care doctor to make shared decisions about medications and lifestyle. The goal is to see if this team-based approach improves heart and kidney health scores and medication adherence. The st…

This study tests whether a blood test measuring the sFlt-1/PlGF ratio can help doctors decide the best time to deliver babies in women with severe early-onset preeclampsia. The trial will include 386 pregnant women between 30 and 34 weeks of gestation. Half will have delivery tim…

This trial will compare three drugs—dopamine, norepinephrine, and epinephrine—to see which works best for people experiencing a pulmonary hypertensive crisis, a life-threatening spike in blood pressure in the lungs. The study will enroll 75 adults with pulmonary arterial hyperten…

This study tests whether a 12-week tele-pulmonary rehabilitation program, done at home via an app with a physiotherapist, helps people with chronic lung diseases start and stick with rehab better than going to a center. 90 patients will be randomly assigned to either remote rehab…

This pilot study tests a new device that uses radiofrequency energy to calm overactive kidney nerves, which can drive high blood pressure. Twenty adults with untreated mild hypertension will either get the real procedure or a sham (fake) one. The main goal is to see if the real t…

This pilot study tests whether a connected blood pressure monitor, supervised daily by a healthcare assistant, helps patients with blood cancers like CLL or lymphoma stick to home monitoring. The goal is to catch and manage high blood pressure early, a common side effect of BTK i…

This study tests whether a low dose of colchicine, a common anti-inflammatory drug, can slow down blood vessel hardening and bone problems in people with stage 3 chronic kidney disease. About 60 adults will take colchicine or receive usual care for 12 months. The goal is to see i…

This study will test a device called EkoSonic in 30 Chinese patients with acute pulmonary embolism (blood clots in the lungs). The device uses ultrasound to help break up clots while delivering clot-busting medicine. The main goal is to see if it improves heart function within 48…

This study tests whether mazdutide, a weekly injection that helps with weight loss, can slow the buildup of fatty plaque in the heart arteries of 116 overweight or obese adults with coronary heart disease. Participants will receive either the drug or a placebo for 52 weeks, and d…

This study tests a mobile app called TansiyoRitim for people with high blood pressure. The app provides educational videos, texts, and reminders to help users control their blood pressure, take their medication as prescribed, and feel more confident in managing their condition. R…

This phase 2 trial tests a dietary supplement called 2-HOBA in 12 adults with pulmonary arterial hypertension (PAH), a condition where high blood pressure in the lungs strains the heart. Participants take the supplement three times daily for 12 weeks. The study checks if 2-HOBA i…

This Phase 3 trial tests whether adding baxdrostat (Baxfendy) to standard care can improve heart structure and function in 286 adults with high blood pressure and thickened heart walls. Participants take either baxdrostat or a placebo daily for 12 months, with heart scans and reg…

This study will follow 5,000 adults with carotid artery disease who receive a treatment called TCAR using the ENROUTE system. The goal is to see how safe and effective the device is in real-world settings, especially for groups not well-studied before. Researchers will track majo…

This trial investigates whether a diet rich in polyphenols—including daily cocoa and extra fruits and vegetables—can reduce oxidative stress and improve blood vessel function in pregnant women. Researchers will randomly assign 60 pregnant women to receive dietary counseling and c…

This study tests whether pharmacists can encourage doctors and patients to switch to a single pill that combines multiple blood pressure medicines. About 720 adults with high blood pressure will take part. The goal is to see if this approach helps lower blood pressure more effect…

This trial tests whether a specialized scoring balloon, called Naviscore, can better prepare calcified coronary arteries before placing a drug-eluting stent. Hardened plaques often prevent stents from expanding fully, raising risks of re-narrowing or clots. About 200 adults with …

This study tests the safety and tolerability of sotatercept in Japanese children aged 1 to 18 with pulmonary arterial hypertension (PAH), a condition where blood vessels in the lungs narrow, making the heart work harder. Participants receive sotatercept injections every three wee…

This study will test whether measuring blood pressure at home and having weekly phone meetings with a pharmacist can help control high blood pressure. About 420 adults from two emergency department clinics will take part. Half will use the home monitoring and telehealth program f…

This study tests NeoMayor, a smartphone app that gives personalized advice on exercise, diet, sleep, and mood to improve heart health. Researchers will enroll 240 adults aged 55 to 75 in Chile who are at risk for heart problems. Participants use the app for 4 months, and some als…

This Phase 2 trial tests whether a fixed-dose combination of leucine, sildenafil, and metformin (NS-0200) can lower blood pressure in adults aged 18 to 75 with hypertension. About 150 participants receive one of two doses of the combination or a placebo for 12 weeks. The main goa…

This study tests whether a 12-week program of moderate aerobic exercise and inspiratory muscle training can improve breathing, exercise capacity, and quality of life in people with pulmonary hypertension caused by lung disease. Participants will walk on a treadmill and use a brea…

This study looks at whether icosapent ethyl, a purified fish oil medication, can reduce inflammation and improve heart structure in people with coronary artery disease. Researchers will follow 420 patients for one year, comparing those who receive standard care plus icosapent eth…

This study looks at how a special balloon called the OPN balloon is used to open severely hardened or blocked heart arteries. Researchers will track 300 adults who need this procedure to see how well it works and what problems might happen. The goal is to learn the best ways to u…

This early-stage study tests a new drug called HJB647 in Japanese adults with elevated blood pressure or mild-to-moderate hypertension. The main goal is to check safety and how the drug moves through the body. About 74 participants will receive either HJB647 or a placebo, with do…

This study looks at people with a rare lung condition called CTEPH who have done well after a procedure (balloon angioplasty) and are taking a drug called riociguat. The goal is to see if stopping the drug is as safe as continuing it. About 150 participants will be randomly assig…

This study looks at whether low doses of two older blood pressure drugs, spironolactone and chlorthalidone, can safely lower blood pressure in people with moderate to advanced chronic kidney disease (CKD). About 160 U.S. Veterans with CKD and high blood pressure will take the dru…

This study tests whether a 12-week program of healthy eating, supervised exercise, and wellness coaching can lower blood pressure and improve kidney health in adults with advanced chronic kidney disease. Participants are randomly assigned to either the lifestyle program or routin…

This early study tests a small ring placed in the eye that slowly releases the drug bimatoprost to lower eye pressure in people with glaucoma or ocular hypertension. The ring is implanted during a quick surgery and may work for up to 3 years. The trial includes 24 adults and comp…

This study compares two types of blood thinners—antiplatelet drugs (like aspirin) and anticoagulants (like warfarin)—in 1100 people who have a torn neck artery causing a stroke or mini-stroke. The goal is to see which strategy better prevents another stroke, major bleeding, or de…

This study compares a moderate statin (pitavastatin) combined with ezetimibe against high-intensity statins (atorvastatin or rosuvastatin) in patients aged 75+ with coronary artery disease who need a stent. The goal is to see if the combo is just as good at preventing heart attac…

This study looks at a special stent (a small mesh tube) coated with a drug called sirolimus, used to open blocked heart arteries. Researchers will follow 300 adults who received this stent during a standard heart procedure to see how safe and effective it is over 5 years. The mai…

This study tests whether adding extra ultrafiltration (a gentle fluid-removal procedure) for 4 or 8 weeks can safely reduce excess fluid in people on hemodialysis. The goal is to lower high blood pressure and relieve symptoms like congestion. About 120 adults with end-stage kidne…

This study tests whether a mobile health program—combining home blood pressure monitoring with virtual coaching—can help midlife women control high blood pressure after having had a hypertensive disorder of pregnancy (like preeclampsia). About 50 women who had such a pregnancy 10…

This study looks at whether eating all meals within an 8-hour window earlier in the day can improve heart health in adults aged 60 and older who have high blood pressure and often skip breakfast. Over 12 weeks, participants will either follow this eating schedule or stick to thei…

This Phase 3 trial tests aprocitentan, a drug already approved in some countries, for people with resistant hypertension—high blood pressure that stays high despite taking three or more medications. About 382 adults will receive either the drug or a placebo for 8 weeks. The main …

This study tests whether a short, controlled clamping of the aorta before aneurysm surgery can prevent acute kidney injury. About 206 patients will be randomly assigned to receive this preconditioning or standard care. The goal is to see if this simple procedure lowers the risk o…

This study looks at a device called ShortCut that splits old heart valve leaflets before placing a new valve inside it. The goal is to keep the arteries open and prevent blockages. About 150 people with aortic stenosis who are at risk for this complication will take part. Researc…

This study tests whether using a computer simulation (virtual stenting) before placing stents in heart arteries can lead to better outcomes than the usual method guided by X-ray images alone. About 1,472 adults with coronary artery disease will be randomly assigned to either the …

This trial tests a special balloon coated with a drug (paclitaxel) to treat blockages in the leg arteries caused by cholesterol buildup. The balloon is inflated to open the artery and release the drug to help keep it open. The study will include 200 people and check if the balloo…

This study is checking the long-term safety of a daily pill called IKT-001 for people with pulmonary arterial hypertension (PAH), a serious lung condition. About 484 adults who have already completed an earlier IKT-001 study will take the drug for an extended period. Researchers …

This study tests whether a mobile app (MOM-HD) can help pregnant women with high blood pressure or diabetes monitor their blood pressure and blood sugar at home. About 864 women in Nepal will either use the app plus standard care or standard care alone. The goal is to see if home…

This study tests whether a care model led by rural doctors and supported by telemedicine can reduce strokes, heart failure, and heart-related deaths in adults aged 65 and older who are at high risk of stroke in rural China. About 2,500 participants from 39 village clinics will be…

This study tests a liquid herbal supplement called DBPS in 198 adults with prehypertension (blood pressure slightly above normal). Participants will take the supplement or a placebo daily for 4 weeks. The goal is to see if the supplement can lower blood pressure and help prevent …

This pilot study in Colombia will test whether a nursing program that tailors education and counseling to each patient's needs can help people with high blood pressure or type 2 diabetes stick to their medications and achieve better disease control. About 100 to 200 adults alread…

This trial tests a new type of stent that dissolves over time for children under 9 with narrowed arteries in or near the heart. The stent opens the vessel and then gradually disappears, allowing the artery to grow naturally. The study will enroll 45 children and follow them for 5…

This study gives 400 adults with diabetes or high blood pressure free home-delivered produce boxes and vouchers for 6 months, plus nutrition education and self-management classes. The goal is to see if this helps them eat more fruits and vegetables, feel less food insecure, and i…

This study compares two drugs, vasopressin and norepinephrine, given during and after surgery to remove chronic blood clots from the lungs. The goal is to see which drug better controls blood pressure in the lungs without harming the rest of the body. About 90 adults scheduled fo…

This study will follow up to 250 adults who receive the KONECT RESILIA device, which replaces both the aortic valve and the ascending aorta in one surgery. The goal is to see how safe and effective the device is in real-world use. Participants must have a diseased aortic valve an…

This study tests whether customizing ventilator settings during heart bypass surgery can lower the risk of lung complications like pneumonia or respiratory failure. Researchers will compare a standard approach with one that adjusts settings based on lung mechanics. Eighty adults …

This study tests whether a wearable monitoring system (ECG patch, temperature patch, and pulse oximeter) can reduce major heart complications in hospitalized patients with heart disease. About 1500 adults will be monitored either with standard care (vital signs every 4-8 hours) o…

This study tests a step-by-step treatment plan for people with a narrowed aortic valve who also have leaky mitral or tricuspid valves. After a minimally invasive procedure to fix the aortic valve, doctors will check if the other valves still leak badly. If so, additional procedur…

This early study tests a new device called the GORE Multibranch Arch Endoprosthesis for people with aortic arch conditions like aneurysms or dissections. The device is placed inside the blood vessel to repair the damaged area. The study will enroll 20 participants and follow them…

This study compares two supervised treadmill exercise programs for people recovering from coronary artery disease or a heart procedure. One group does high-intensity interval training (HIIT) — short, hard efforts with rest periods — while the other does moderate-intensity continu…

This early-stage trial tests a drug called CSL300 (clazakizumab) in 24 Chinese adults with end-stage kidney disease who are on dialysis. The drug is an antibody that blocks interleukin-6, a protein involved in inflammation. The main goal is to see how the drug moves through the b…

This study will compare three approaches before gastric bypass surgery for severe obesity: taking the medication tirzepatide for 60 days, following a ketogenic diet for 4 weeks, or receiving standard care. The goal is to see which method leads to the most weight loss one year aft…

This study looks at whether a long-acting injectable HIV prevention drug (cabotegravir) can be delivered fairly and effectively in NHS sexual health clinics. Researchers will follow 200 people taking the drug for 12 months, along with 20 healthcare professionals, to see how well …

This study tests whether adding a Chinese herbal medicine called Qidan Xiaoke Granules to standard heart drugs can reduce major heart problems like heart attacks or repeat procedures in people who have had a stent placed. About 164 adults with coronary artery disease will take th…

This study looks at whether a common heart valve procedure called TAVI is safe when done in hospitals that don't have heart surgery available on-site. About 600 people with severe aortic stenosis will be randomly assigned to have TAVI either with or without surgical backup. The g…

This study will compare a newer, less invasive heart procedure called hybrid revascularization to standard coronary artery bypass grafting (CABG) in over 1,000 people with multiple blocked heart arteries. The hybrid approach combines a small incision to graft a key artery with st…

This Phase 3 trial tests a new eye drop, DNN.31.19.026, against a standard treatment (Cosopt) for people with high eye pressure or open-angle glaucoma. About 336 adults will use the drops twice daily for 56 days. The main goal is to see if the new drop lowers eye pressure better …

This study looks at whether doing a balloon angioplasty or placing a stent right after removing a blood clot from the brain can help people who have a stroke caused by a hardened artery. About 420 adults will be in the study. The goal is to see if this extra step improves recover…

This study will test if a smart pill bottle cap, called FORTISKAP™, helps people with serious lung diseases like pulmonary fibrosis, sarcoidosis, and pulmonary hypertension take their oral medications more consistently. About 100 participants will either use the smart cap or rece…

This study compares two cholesterol-lowering strategies in 6,000 Chinese patients with very high-risk heart disease. One group aims for ultra-low LDL cholesterol below 1.0 mmol/L, while the other targets a moderate level of 1.0-1.39 mmol/L. Researchers will track heart attacks, s…

This Phase 3 study tests VI-0106, an extended-release form of tacrolimus, in 300 people with pulmonary arterial hypertension (PAH) who still have trouble with daily activities despite taking standard PAH medications. Participants will receive either the drug or a placebo for 24 w…

This study tests a stent-graft that doctors modify before use to treat complex aortic aneurysms. It involves 20 high-risk patients who cannot have standard open surgery. The goal is to see if the device is safe and prevents aneurysm growth or rupture.

This study compares two approaches for people with heart failure and narrowed heart arteries: a stent procedure plus guideline-directed medications versus medications alone. About 1,150 participants will be followed for at least two years to see which group has fewer major heart …

This study tests whether Baduanjin, a gentle traditional Chinese exercise, helps people recover after heart bypass or stent surgery. Researchers will track 310 adults for up to a year to see if it lowers the risk of heart attacks, chest pain, or the need for more procedures. The …

This phase 3 study tests the long-term safety of an inhaled drug called treprostinil palmitil for people with pulmonary hypertension caused by interstitial lung disease. About 344 adults who completed an earlier trial will take the drug for up to 2 years. Researchers will track s…

This study tests a drug called 2-HOBA in 20 adults with salt-sensitive high blood pressure. The drug aims to calm overactive immune cells that may worsen blood pressure when salt is eaten. Researchers will measure blood pressure changes and blood vessel health after taking 2-HOBA…

This early-stage study tests a new tablet called HS-10522 in healthy Chinese adults and those with mild hypertension. The main goal is to check safety and how the drug moves through the body. 88 participants will receive either the drug or a placebo to compare side effects and dr…

This study tests whether combining a Bluetooth blood pressure monitor with regular support from a community health worker can help Black women control high blood pressure after pregnancy. About 404 women will be randomly assigned to either this extra support or standard care. The…

This pilot study tests two ways of running a temporary heart pump (Impella CP) during a high-risk procedure to open blocked heart arteries in patients with weakened heart muscle. Fifty patients will be randomly assigned to either an automatic mode that adjusts flow or a fixed low…

This study tests a procedure called renal denervation, which uses a catheter to calm overactive nerves in the kidneys, in 1,000 people with both resistant hypertension and multivessel coronary artery disease. Participants will undergo the procedure during a planned heart stent op…

This phase 2 trial tests whether adding tiprelestat (elafin) to standard care improves blood flow in the lungs for people with pulmonary arterial hypertension (PAH). About 90 adults with moderate to severe PAH will receive either a daily injection of tiprelestat or a placebo for …

This study tests whether giving a clot-busting drug called tenecteplase before a mechanical clot removal procedure helps people with large ischemic strokes recover better than the procedure alone. About 486 adults with large-vessel occlusion strokes will be randomly assigned to o…

This study will look at how well a drug called ARNi (sacubitril/valsartan) lowers blood pressure in 500 adults with hypertension in the United Arab Emirates. Researchers will compare it to standard treatments like ACE inhibitors and calcium channel blockers. The goal is to see if…

This study tests whether a new wire-free imaging method called μFR can help doctors decide which blocked heart arteries need stents after a heart attack. About 350 patients with multiple blocked arteries will be randomly assigned to standard care or μFR-guided treatment. The goal…

This study tests whether a tablet-based brain training program and/or a powerful cholesterol-lowering drug (PCSK9 inhibitor) can improve thinking and memory in 420 adults aged 55-80 with narrowed brain arteries. Participants will be split into four groups, combining or not combin…

This study will test whether taking ginger supplements for two months can lower inflammation and oxidative stress in people with coronary artery disease. Fifty adults with confirmed heart disease will be randomly assigned to receive either ginger extract or a placebo. Researchers…

This study looks at whether giving people with high blood pressure and food insecurity $100 a month for fruits and vegetables can improve their health. It focuses on Native Hawaiian and Pacific Islander adults in Hawaii. Some participants will also get one-on-one help from a comm…

This study tests whether keeping elderly patients on their side for 15 minutes after spinal anesthesia, instead of lying on their back, can prevent blood pressure drops. Researchers will enroll 70 high-risk patients aged 65 and older having leg surgery. The approach aims to keep …

This pilot study tests a special pacemaker-like device called Moderato Plus in 20 people with high blood pressure and a type of heart failure where the heart pumps normally but is too stiff (HFpEF). The device delivers Cardiac Neuromodulation Therapy to help control blood pressur…

This study looks at whether taking royal jelly and propolis (natural bee products) for two months can lower inflammation and improve heart health in 50 adults with coronary artery disease. Participants will be randomly assigned to receive the supplements or a placebo, and researc…

This study compares two ways to remove blood clots from the brain during a stroke. About 500 adults who have a stroke from a large blocked artery will be randomly assigned to one of two standard techniques: a cyclic 'plunger' method or a steady suction method. The goal is to see …

This small pilot study will test a program where nurses and general practitioners help breast cancer survivors who also have heart disease make healthy lifestyle changes. The program includes exercise, diet changes, quitting smoking, and stress-reducing activities like yoga. The …

This study tests a new approach for women with chest pain who don't have blocked arteries. Doctors will use special tests to find the exact cause of the pain, then give each woman a personalized treatment plan. The goal is to see if this tailored approach improves symptoms and qu…

This study compares 1 month versus the standard 6 months of dual antiplatelet therapy (two blood thinners) in people who had a balloon procedure for small coronary artery disease. About 1,484 adults with stable angina or silent ischemia will be randomly assigned to either short o…

This study tests whether two heart failure medications, dapagliflozin and spironolactone, can help the heart recover better after aortic valve replacement. About 445 adults with severe aortic stenosis will take one or both drugs daily for 12 months. The goal is to see if these me…

This study tests whether the drug vericiguat can prevent serious heart and organ problems in people undergoing heart surgery. About 600 high-risk patients will receive either vericiguat plus standard care or standard care alone. The goal is to see if vericiguat reduces early comp…

This study tests whether adding alirocumab (a cholesterol-lowering injection) to standard statin therapy can reduce bleeding inside fatty plaques in the carotid artery. About 280 people with a recent mini-stroke or stroke due to a 50-69% blocked neck artery will receive either al…

This study tests whether the drug propranolol can prevent heart injury after breast cancer surgery in women who also have high blood pressure or angina. One hundred participants will either receive propranolol before surgery or standard care. Researchers will measure heart stress…

This study tests a new laser treatment called DSLT for people with high eye pressure or open-angle glaucoma who have already had a similar laser (SLT). The DSLT laser does not touch the eye, which may make it faster and more comfortable. Researchers want to see how well it lowers…

This study will test whether an artificial intelligence (AI) system can help community doctors better manage patients who have high blood pressure along with diabetes or high cholesterol. About 6,800 adults will be split into two groups: one where doctors use the AI tool to guide…

This study tests whether adding Vitamin C, Omega-3 fatty acids, lignin, and lactulose to standard care can improve recovery in 108 adults after coronary artery bypass grafting (CABG). Participants will take the supplements daily for 10 weeks starting 15 days after surgery. The go…

This study looks at whether setting a pacemaker to a personalized rate of 75 beats per minute, instead of the usual 50-60, can improve heart function and blood flow to the brain in people with high blood pressure and a slow heart rate. About 70 patients aged 65 and older will be …

This pilot study checks if a bigger trial on low-dose aspirin for people with early, symptom-free coronary artery disease can be done. It will enroll 48 adults with signs of artery narrowing but no symptoms. The main goal is to see if doctors can recruit enough patients and if pa…

This study tests a traditional Chinese medicine mixture (red ginseng, notoginseng, and rhubarb) to help people recover from a hypertensive brain bleed without surgery. About 902 participants will receive either the herbal mix or a placebo for 28 days, alongside standard care. The…

This study compares a drug-coated balloon (DCB) to a drug-eluting stent (DES) for treating new blockages in heart arteries. About 1,548 adults with stable or unstable angina, old heart attacks, or silent ischemia will be randomly assigned to one of the two treatments. The main go…

This study compares two standard procedures—minimally invasive TAVR and open-heart surgery (SAVR)—for replacing a diseased aortic valve in people with a bicuspid aortic valve. About 1,200 participants aged 50 and older with severe aortic stenosis will be randomly assigned to one …

This study tests a non-invasive device that uses gentle electrical stimulation on the brain to see if it can safely lower blood pressure in people with mild hypertension. Sixty adults aged 30-65 with mild high blood pressure will receive either real or sham stimulation for 20 min…

This pilot study is testing whether a Bifidobacterium probiotic supplement can help lower blood pressure in 30 middle-aged Chinese adults with untreated hypertension. Participants will take the probiotic for 12 weeks, and researchers will monitor their blood pressure and other he…

This study tests a program called Moxie that sends weekly mail and a mobile app to help people with chronic heart, kidney, or diabetes conditions manage their health after a hospital stay. The goal is to see if it reduces the chance of going back to the hospital. About 9000 adult…

This study is for adults aged 40 and older who have two or more chronic conditions like high blood pressure, diabetes, or depression. Researchers are testing a program that includes a digital decision-support system for doctors, telemedicine for specialist advice, and a mobile ap…

This study tests whether an early, aggressive approach—using a catheter to open and stent high-risk plaques seen on a CT scan—plus medication is better than medication alone for preventing heart problems. About 2,500 people with coronary artery disease will be randomly assigned t…

This study tests a non-invasive device called the Hypotension Prediction Index (HPI) in 60 elderly patients (ages 65-90) undergoing shoulder surgery in a beach chair position. The device predicts when blood pressure might drop dangerously low, allowing doctors to intervene early.…

This study tests whether the drug finerenone can help people with heart failure who have had a heart valve replacement (TAVI). About 2,800 older adults will be randomly assigned to receive finerenone or a placebo. The goal is to see if the drug lowers the chance of death or worse…

This study tests whether using a balloon guide catheter during carotid artery stenting can prevent small particles from traveling to the brain and causing strokes. About 126 people with narrowed neck arteries will be randomly assigned to receive the balloon protection or standard…

This early study tests a new device that combines a balloon with sound waves to treat blocked arteries in the legs, a condition called peripheral artery disease (PAD). The device is designed to crack hard plaque and widen the artery. The study will include 30 people with moderate…

This study looks at how safe and effective the SAPIEN 3 heart valve is for people with a certain type of bicuspid aortic valve stenosis (Type-0). About 170 people in China will be observed after the procedure to track serious problems like death, stroke, or rehospitalization. The…

This study will test whether a low-sodium salt substitute, which contains potassium chloride, is safe for adults with high blood pressure who are on medication. About 607 participants in Bangladesh will replace regular salt with the substitute for a period. Researchers will monit…

This phase 1/2 trial tests whether a patient's own stem cells, taken from belly fat and grown in a lab, can heal leg ulcers caused by severe peripheral artery disease. 40 participants will either receive stem cell injections and a special cell-containing dressing, or standard hyd…

This study tests a new, non-drug treatment for high blood pressure called high-intensity transcranial alternating current stimulation (Hi-tACS). It uses gentle electrical currents on the scalp to stimulate the brain. The trial will include 50 adults with primary hypertension to s…

This study tests whether drinking a specially designed milk every day for a year can reduce the chance of stents narrowing again and prevent further heart problems in people who have had a first heart attack. About 140 adults who recently had a stent placed will be randomly assig…

This study compares a new heart valve implant (Myval) to standard medication in 778 people aged 65+ with moderate aortic stenosis. The goal is to see if the implant reduces death, stroke, heart failure, and improves quality of life over 2 years. Participants will be randomly assi…

This study will track 100 people with severe aortic stenosis who receive the Hydra THV heart valve through a less invasive procedure (TAVR). The goal is to see how well the valve works and how safe it is in everyday practice. Participants will be followed for short- and mid-term …

This study compares a new stent that releases sirolimus and ascorbic acid (vitamin C) to a standard everolimus-releasing stent in over 2,000 people with coronary artery disease. The goal is to see if the new stent is as good at preventing heart-related complications like death, h…

This study tests whether covered stents are better than bare metal stents for people with narrowed kidney arteries caused by atherosclerosis. About 150 participants will be randomly assigned to one stent type and followed for 12 months to see changes in kidney function and blood …

This phase II trial tests whether adding bosentan to standard steroid treatment helps people with giant cell arteritis (GCA) avoid relapses and reduce steroid use. About 40 adults with GCA will receive either bosentan plus steroids or steroids alone for 3 months, then be followed…

This trial tests whether the Adacolumn device, which filters certain white blood cells from the blood, can reduce brain swelling in people who have had a severe stroke. Ten patients will receive the treatment within 24 hours of their stroke. The goal is to see if it prevents wors…

This small pilot study will test a pharmacist-led program to control high blood pressure and cholesterol in 10 people aged 50-75 who carry the APOE ε4 gene, a major risk factor for Alzheimer's. Participants will take specific medications for six months to see if managing these he…

This study tests whether a device that temporarily restricts blood flow to the arms (remote ischemic conditioning) can help lower blood pressure in people with hypertension who moved to high-altitude areas. 184 adults will either continue their usual medication or add the device …

This trial tests a new stent called SILANCE for people with idiopathic intracranial hypertension (IIH), a condition where high pressure inside the skull causes severe headaches, ringing in the ears, and vision problems. The stent is placed in a narrowed vein in the brain to impro…

This study tests whether people with giant cell arteritis (GCA) can safely take steroids for only 8 weeks instead of the usual 26 weeks when also using the drug tocilizumab. About 178 participants will be randomly assigned to one of two treatment lengths. The goal is to see if th…

This study tests whether TA-65, a dietary supplement that activates telomerase, can improve small blood vessel function in healthy older adults and people with coronary artery disease. Researchers will measure blood vessel responses and blood pressure in 180 participants. The goa…

This study tests whether using a 21-question tool to understand a person's daily habits, then giving tailored advice, can lower blood pressure more than routine counseling. Researchers will compare two groups of adults with hypertension over three months. The goal is to see if pe…

This pilot study tests whether midodrine, a drug that raises blood pressure, can help heart failure patients with low blood pressure tolerate standard heart medications. About 56 hospitalized adults with weak heart pumps and low blood pressure will receive midodrine or usual care…

This study looks at people with narrowed kidney arteries and high blood pressure. It uses a special pressure measurement (FFR) to decide who gets a stent and who gets only medication. The goal is to see which approach better protects kidney function and controls blood pressure ov…

The ROOT study is testing a personalized nutrition program for pregnant women. Participants receive standard prenatal care plus customized diet and lifestyle plans based on their genes and nutrient levels. The goal is to see if this approach can lower the chances of preterm birth…

This early-stage study tests a single injection of a new drug, IBI3016, in 30 Chinese adults with mild to moderate hypertension who are not currently on blood pressure medication. The main goal is to check safety and how the drug moves through the body, with a secondary look at i…

This study tests if using only drug-coated balloons is as safe and effective as stenting for treating blocked heart arteries at branch points. About 272 people with chronic coronary syndrome will be randomly assigned to one of the two treatments. Researchers will track deaths, he…

This study tests whether a clinical decision support tool, embedded in electronic medical records, helps doctors prescribe more effective blood pressure medications. About 168 adults with uncontrolled hypertension will be enrolled. The main goal is to see if the tool leads to low…

This study tests whether a minimally invasive procedure called endovascular treatment can help people who have a progressive stroke caused by a blockage in the main artery at the back of the brain. The procedure uses a catheter to remove or open the clot. The trial will include 2…

This study looks at how long people should take a combination of two blood thinners (ticagrelor and aspirin) after coronary artery bypass surgery to keep the new vein grafts open. 300 patients will be randomly assigned to take the combination for 3, 6, or 12 months, then switch t…

This study tests whether a medicine given as a nose spray before a heart stent procedure can reduce heart muscle injury or heart attack. About 1800 adults scheduled for elective stent placement will receive either the medicine or a placebo spray. Researchers will measure heart da…

This study compares two surgical techniques for coronary artery bypass grafting (CABG). One uses only arteries (total arterial grafting), while the other uses a mix of artery and vein grafts (conventional mixed grafting). The goal is to see which approach keeps grafts open longer…

This study tests whether giving a drug called tirofiban directly into the artery right after a clot is removed can help people recover better from a severe stroke. About 344 adults who had a large-vessel blockage stroke will be randomly assigned to receive the drug or not. The ma…

This study tests whether a drug-coated balloon (DCB) is as safe and effective as a drug-eluting stent (DES) for treating large blockages in heart arteries. About 2,492 patients will be randomly assigned to receive either a balloon or a stent, guided by advanced imaging. The goal …

This trial compares two latest-generation heart valves (SAPIEN 3 Ultra Resilia and Evolut FX) in 200 patients with severe aortic stenosis. Participants will be randomly assigned to receive one valve during a standard procedure and followed for one year. The goal is to see which v…

This study tests a 3-month behavioral coaching program for 232 adults with coronary heart disease who sit a lot. The program includes face-to-face and phone sessions to help them reduce sitting time and increase physical activity. Researchers will measure changes using activity t…

This study will test if using artificial intelligence to find calcium buildup in heart arteries from chest CT scans people already had can improve cholesterol treatment. Researchers will notify patients and their doctors about the finding, aiming to start or strengthen cholestero…

This study will give 150 children and teens with high blood pressure, high cholesterol, or obesity a free debit card to buy fruits and vegetables, plus virtual nutrition classes. The goal is to see if this program helps improve their heart health over 6 to 12 months. Participants…

This study tests whether using only ultrasound (echocardiography) to guide a minimally invasive heart valve replacement is as effective as the standard method that combines X-ray and ultrasound. The goal is to reduce kidney injury from contrast dye and lower radiation exposure. A…

This study tests whether a drug-coated balloon is as good as or better than a drug-eluting stent for people with multiple blocked heart arteries. About 892 adults with stable heart disease or recent heart attack will be randomly assigned to one of the two treatments. The goal is …

This pilot study tests whether giving semaglutide (Ozempic) to 100 stroke patients who had a clot-removal procedure can improve recovery. Patients are randomly assigned to receive weekly injections for 12 weeks or no drug. The main goal is to see if a larger, definitive trial is …

This study looks at whether a program called HEARTS can help people who have both high blood pressure and diabetes get better care. About 1,440 adults in Guatemala will take part, and clinics will either use the HEARTS program or continue their usual care. The program includes tr…

This trial tests a hybrid exercise program (HyBEST) for people with coronary artery disease. It combines supervised sessions at a center with home workouts using a wearable tracker. The goal is to see if this approach improves exercise capacity, body composition, and quality of l…

This pilot study will test whether training hair stylists to check blood pressure, combined with home monitoring, health coaching, and pharmacist support, can help Black and Hispanic women lower their blood pressure. About 144 women who visit participating salons will be randomly…

This study tests whether a low-dose anti-inflammatory drug called colchicine can help people with severe leg artery disease (chronic limb-threatening ischemia) avoid amputation or death. About 200 adults who recently had a procedure to restore leg blood flow will take either colc…

This study compares two drug-coated balloons for treating narrowed or blocked arteries in the leg. The experimental balloon uses sirolimus, a drug that stops cells from growing and blocking the artery again, while the standard balloon uses paclitaxel. About 478 people with leg ar…

This study will test whether sending reminders by text, email, or secure patient portal messages helps people with heart disease or diabetes refill their statin prescriptions. About 22,000 adults who have not refilled their statin in the last 3 months will receive one of these me…

This registry will follow 200 people with severe aortic valve stenosis who receive a non-invasive ultrasound therapy called Valvosoft. The treatment uses focused sound waves to soften calcium buildup on the valve without surgery. Researchers will track safety and effectiveness fo…

This Phase 3 trial tests a new injectable drug, ongericimab, in about 4,800 people who recently had a stroke due to narrowed arteries. The goal is to see if lowering LDL cholesterol more than current standard care can prevent future strokes, heart attacks, or death from heart dis…

This study tests whether a 12-month digital program with health coaching and a wearable device can reduce scarring in the heart muscle caused by high blood pressure. Researchers will enroll 200 adults aged 40-70 with early signs of heart thickening. The goal is to see if lifestyl…

This study tests a new way of managing care for older adults (ages 60-74) who have both high blood pressure and type 2 diabetes. About 960 people from rural community health centers will either receive the new integrated care package or continue with standard care. The goal is to…

This study tests whether the drug butylphthalide can reduce brain swelling in people who have had a severe stroke and undergone a procedure to reopen a blocked artery. About 100 adults will receive either the drug or a placebo for up to 14 days. Researchers will measure changes i…

This study tests whether shining a specific red laser light on the wrist (over the radial artery) can improve blood pressure and blood vessel function in people with hypertension who are already taking the medication losartan. Eighty adults will be randomly assigned to receive ei…

This study tests whether a smartphone app powered by artificial intelligence can help adults recover after heart surgery. 500 patients will either use the app plus standard care or standard care alone. The app gives personalized advice on medications, spotting complications early…

This study tests a new method for closing the breastbone after coronary artery bypass graft (CABG) surgery using special knotless barbed sutures and a skin adhesive. Researchers will compare 401 adults who receive this new closure to past patients who had standard closure. The go…

This study tests whether cooling the head (using a special cap) during emergency stroke treatment can reduce the amount of brain tissue that dies. About 182 adults having a major stroke and undergoing a clot-removal procedure will be randomly assigned to receive either standard c…

This trial is for people whose surgically implanted aortic heart valve has stopped working properly. It compares two types of replacement valves placed through a tube in the leg (TAVI): a newer self-expanding valve (Hydra) versus standard balloon-expandable valves (Sapien or MyVa…

This study tests whether a short digital education program can improve self-care and health literacy in people with high blood pressure. 166 adults aged 50 and older will attend two 15-20 minute sessions covering healthy habits and digital health tools. Researchers will compare t…

This study tests a drug called YN001 in 456 adults with coronary atherosclerosis (plaque buildup in heart arteries). Participants receive weekly injections of YN001 or a placebo for 13 weeks. The main goal is to see if YN001 reduces plaque volume in the arteries, as measured by a…

This study tests whether using a blood-pressure cuff device (called chronic remote ischemic conditioning) along with mindfulness audio sessions can improve blood flow to the heart in people with coronary artery disease who couldn't have all blockages opened. About 480 adults with…

This study tests a new device called the Shockwave C2 Aero, which uses sound waves to break up calcium deposits in heart arteries before placing a stent. About 200 people with coronary artery disease will be enrolled across 8 U.S. sites. The goal is to see if the device works saf…

This study tests a device that uses sound waves (lithotripsy) to break up calcium buildup in the carotid arteries—the main arteries in the neck—before placing a stent to keep them open. The goal is to see if this approach reduces complications like stroke, heart attack, or death …

This study tests whether the drug telaglenastat, taken twice daily for 12 weeks, can safely lower blood pressure in the lungs and improve heart and lung function in adults with pulmonary hypertension. About 28 participants will receive the drug on top of their usual care. The mai…

This study looks at whether a common heart valve replacement (TAVI) can be performed safely in hospitals that do not have a cardiac surgery team on-site. Currently, TAVI is only done in hospitals with heart surgery backup, which can cause long wait times. The trial will randomly …

This study tests a new device that uses sound waves (lithotripsy) to break up hard calcium deposits in the carotid arteries of the neck before placing a stent. About 185 people with heavily calcified carotid arteries will be enrolled. The main goal is to see if the procedure is s…

This study tests whether a drug called a PCSK9 inhibitor (Tafolecimab) can slow the progression of mild to moderate calcific aortic stenosis, a condition where the heart valve narrows and hardens. Researchers will give the drug to half of 160 participants and compare changes in v…

This study tests whether canagliflozin, a diabetes drug, can reduce dangerous brain swelling and bleeding in people who have had a severe stroke and are receiving clot-removal therapy. About 150 adults will be randomly assigned to take the drug for 14 days or receive standard car…

This pilot study tests a simple method to reduce wound complications after groin vascular surgery. Surgeons will inject a blue dye into the skin around the surgical wound to make any lymphatic leaks visible, then repair them immediately. The study will enroll 60 adults and track …

This registry will follow 500 adults with severe aortic stenosis who receive a SAPIEN 3 Ultra Resilia heart valve through a minimally invasive procedure. Researchers will track how well the valve works and how safe it is over 10 years. The goal is to see if this newer valve desig…

This registry will follow 2000 people with complex coronary artery disease who receive the Inspiron EVO drug-eluting stent. The stent is designed to be easier to deliver and stronger than standard stents. Researchers will track how well the stent works and whether it reduces hear…

This study tests a program to help people with HIV who also have high blood pressure stick to their medication. Participants will get educational materials, a home blood pressure monitor, and regular check-ins with a nurse. The goal is to see if this approach is practical and hel…

This phase 2 trial tests whether secukinumab, a drug that blocks IL-17A, can help people with active severe Takayasu arteritis achieve remission and stop taking steroids. About 52 participants will receive either secukinumab injections or standard care (like TNF inhibitors). The …

This study looks at whether people with atrial fibrillation who have had a successful heart ablation and also have a heart stent can safely stop taking blood thinners. Participants who maintain a normal heart rhythm for at least a year after ablation will either continue blood th…

This study tests whether a daily black seed extract supplement (Nisatol®) can help lower blood pressure in women with borderline high readings or a specific nighttime blood pressure pattern. 106 women will take either the supplement or a placebo for 12 weeks. Researchers will mea…

This study compares two approaches for people who have had a stroke or mini-stroke due to a blocked brain artery that hasn't opened on its own. One group gets a procedure to reopen the artery plus medication, while the other gets medication alone. The goal is to see which approac…

This study tests a drug called sotatercept in 40 adults with congenital heart disease and Eisenmenger syndrome, a serious condition where blood flow in the lungs is blocked. The drug is given as a shot every three weeks for 24 weeks. The goal is to see if it safely lowers pressur…

This study tests a 3-week online lifestyle program for adults aged 60-75 with high blood pressure. The program focuses on healthy eating, exercise, stress management, sleep, social support, and avoiding risky substances. Researchers will measure changes in blood pressure, quality…

This study tests a new radioactive tracer called 18F-FAPI-74 that may help detect scar tissue (fibrosis) in the heart and lungs earlier than current methods. Researchers will compare this new PET/CT scan to standard imaging in 210 adults with conditions like lung disease or heart…

This study tests whether an artificial intelligence system called AngioAI+ can accurately diagnose two types of coronary artery disease using standard angiogram images. The research involves 620 adults with suspected coronary artery disease who are already scheduled for an angiog…

This study explores whether an additional CT scan of the heart, taken right after a standard scan for lung clots, can effectively detect blood clots in the left atrial appendage (LAA) in people with atrial fibrillation. Currently, detecting these clots requires a more involved pr…

This study looks at whether comparing a patient's previous pulmonary artery pressure (PAP) reading with one taken during an ER visit can help doctors quickly identify a pulmonary embolism (a blood clot in the lung). Researchers will review records of 80 adults who come to the ER …

This study will test a new type of PET/CT scanner, called Long-Axial Field-of-View (LAFOV), to see if it can provide clearer images of blood vessel inflammation in people with large vessel vasculitis (LVV). The scanner is more sensitive and can image the whole body faster, potent…

This study will test whether a deep learning-based image reconstruction method can improve the quality of coronary CT scans. Researchers will look at existing scans from 200 patients who had a CT angiogram for suspected heart disease. Two radiologists will rate the images on a sc…

This pilot study will test whether breathing controlled amounts of carbon dioxide (CO2) can help doctors see blood flow in the heart using MRI, without needing standard contrast dyes. Thirty adults with known or suspected coronary artery disease will take part. The goal is to che…

This pilot study tests whether a computer-controlled device that delivers precise gas mixtures can safely help identify coronary artery disease in people without known heart problems. Eighty healthy adults aged 45 and older will breathe different gas concentrations while their vi…

This study looks at whether a special heart scan (CZT-SPECT) can better predict heart attacks, strokes, and heart failure in people with chronic kidney disease. Current tests often miss heart problems in these patients. The study will follow 283 participants for two years to see …

This study tests whether a simple, 1-minute electrocardiogram (ECG) analyzed by artificial intelligence can accurately detect significant blockages in the heart's arteries. Researchers will compare the AI's predictions against standard imaging tests in 400 adults. If successful, …

This study looks at whether measuring the collapsibility of the internal jugular vein in the neck using ultrasound can predict low blood pressure after general anesthesia. Researchers will measure the vein in 42 adults before gallbladder surgery and track blood pressure changes r…

This study is testing whether a simple, 1-minute heart recording (ECG) analyzed by a computer can help detect pulmonary embolism, a serious blood clot in the lungs. Researchers will enroll 500 adults who need to be checked for this condition. The goal is to see if this quick, non…

This study will test a new, non-invasive bedside scan (3D-EIT) to see if it can accurately diagnose and monitor pulmonary embolism (blood clots in the lungs) without using radiation. About 115 adults with and without clots will participate. The goal is to provide a safer, easier …

This study tests advanced CT scans to find dangerous blockages in heart arteries without needing to insert a tube into the heart. About 142 adults with moderate blockages will get two types of CT scans, and results will be compared to the standard invasive test. The goal is to se…

This study tests a new, contactless camera technology that measures heart rate, blood pressure, and heart disease risk from a short video of your face. Researchers will compare these readings to standard medical tests in 300 adults aged 30 and older in Jakarta. If accurate, this …

This early-phase trial tests whether a fluorescent dye called LUMISIGHT (pegulicianine) can light up inflammation in artery plaques removed during surgery. Inflammation is a key driver of heart attacks, but current imaging can't see it clearly. Researchers will compare the dye to…

This study is testing a new wrist device that uses light to measure blood pressure without needing a traditional arm cuff. Researchers will compare its readings to standard methods in 200 adults aged 22 to 59 over one week. The goal is to see if the device is accurate and safe en…

This study will enroll 5000 adults to see if a one-minute, single-lead ECG, analyzed by machine learning, can detect heart conditions like high blood pressure, heart failure, and diabetes. Participants will have their ECG recorded twice and compared with full medical exams. The g…

This study explores whether a low-dose CT scan without contrast dye can accurately detect pulmonary embolism (blood clots in the lungs). Researchers will enroll 750 adults suspected of having a clot and add two very low-radiation CT scans to their standard dye-based scan. The goa…

This study looks at how quickly the optic nerve sheath shrinks after starting steroids in people with giant cell arteritis, a condition that can cause blindness. Researchers will use eye ultrasounds and blood tests over two months in 60 newly diagnosed patients. The goal is to fi…

This study looks at whether blood clots in the lungs (pulmonary embolism) are often missed in people hospitalized with acute heart failure. About 740 patients across multiple hospitals will take part. In half the hospitals, doctors will follow their usual approach; in the other h…

This study will test a computer algorithm called ECGio that analyzes electrocardiograms (ECGs) to see if it can accurately detect significant coronary artery disease (blockages in heart arteries). Researchers will compare ECGio's results to standard imaging tests like angiograms …

This study is testing a new digital stethoscope that listens for subtle changes in heart sounds to detect coronary artery disease and valve problems earlier. Researchers will record heart sounds from 500 adults who are already scheduled for heart scans or echocardiograms. The goa…

This study tests whether washing the surgical wound and the new prosthetic graft with a hypochlorous acid solution at the end of surgery can prevent infections. Participants are adults having open surgery to insert a synthetic bypass graft for narrowed or blocked arteries. The st…

This study tests a personalized support program called PTBCARE+ for pregnant individuals at high risk of delivering early. The program includes a stress reduction toolkit, a website/app, care coordination, and optional massage. Researchers will compare stress levels and birth out…

This study will test whether a 12-week Transcendental Meditation (TM) program can improve stress, mood, and blood pressure in post-menopausal women at risk for hypertension. Sixty women aged 50-80 with mildly elevated blood pressure and stress will be randomly assigned to TM or a…

This study looks at how to make HIV prevention pills (PrEP) easier for young people to get and keep using. Researchers will follow 1000 current or eligible PrEP users in Alabama and Botswana for 2 years. They will also create and test a decision-support toolkit to help patients a…

This study looks at whether pregnant women at high risk for preeclampsia can safely stop taking daily aspirin at 24-28 weeks instead of continuing until 36 weeks. Over 15,000 women across Europe and Africa will be randomly assigned to stop or continue aspirin. The goal is to see …

This study tests whether adding a traditional Chinese medicine formula called Bu Yang Huanwu Decoction (in capsule form) to standard treatment can prevent leg pain at rest or foot ulcers in people with diabetic lower extremity vascular disease. About 300 adults aged 18 to 70 with…

This study tests a special silver-coated mesh placed during emergency abdominal surgery to see if it can prevent surgical site infections and incisional hernias. About 110 adults having urgent open abdominal surgery will take part. Researchers will track infection and hernia rate…

This study tests whether notifying obstetric clinicians when a pregnant patient is at high risk for preeclampsia increases the use of low-dose aspirin, which can help prevent the condition. Researchers will compare clinics that receive these alerts to those that continue usual ca…

This study tests whether taking progesterone early in pregnancy can prevent preeclampsia, a condition that causes high blood pressure and organ damage. Over 600 low-risk pregnant women will either receive nightly vaginal progesterone or standard care. Researchers will track who d…

This study tests whether placing soft foam dressings on the skin before heart surgery can prevent pressure injuries (bedsores). About 80 adults having long heart surgeries will be enrolled. Researchers will check for new skin injuries after surgery and track how severe they are. …

This study tests whether a single dose of cold atmospheric plasma applied to the wound during groin surgery can prevent healing complications in 214 high-risk patients with peripheral artery disease. Half will get the real plasma device, half a sham device. Researchers will track…

This study looks at whether giving patients and their doctors a polygenic risk score — a genetic test that estimates future risk of coronary heart disease — helps more people start taking statins to prevent heart problems. Researchers will enroll 200 adults aged 40-69 without pri…

This study tests whether taking a low dose of colchicine (0.5 mg) every day for two years after coronary artery bypass grafting (CABG) can prevent the new blood vessel grafts from failing. About 622 adults who just had bypass surgery will be randomly assigned to get either colchi…

This study tests whether a numbing injection around a nerve cluster in the neck, given just before heart bypass surgery, can prevent a common complication called atrial fibrillation (irregular heartbeat) in the first week after surgery. About 450 adults scheduled for bypass will …

This study tests whether using portable air cleaners and other indoor air quality measures can lower the risk of heart disease in older adults (ages 55-79) living in Montana, where wildfires are common. Participants will use air cleaning devices at home, and researchers will trac…

This study tests a new way to help young people (ages 13-24) stick with PrEP, a medication that prevents HIV. Participants get PrEP delivered to a community spot (like home or a mobile van) and use a smartphone app for reminders and support. The goal is to see if this combo impro…

This trial tests whether two heart medications, metoprolol and amiodarone, can prevent new-onset atrial fibrillation (AFib) in people who develop minor rhythm issues after transcatheter aortic valve replacement (TAVR). About 198 participants will be randomly assigned to one of th…

This study looks at whether a diet rich in whole white potatoes can improve blood sugar control and blood pressure in adults aged 50-70 who are at risk for type 2 diabetes. Participants will eat either a potato-rich healthy diet or a typical Western diet for 12 weeks. Researchers…

This study tests whether taking 2,000 IU of vitamin D daily during pregnancy can prevent preeclampsia, eclampsia, and HELLP syndrome in about 2,000 pregnant women in Uganda. Half the women will receive vitamin D and half a placebo, and researchers will track outcomes up to six we…

This pilot study explores whether non-drug strategies like virtual reality or relaxing soundscapes can reduce anxiety and pain in adults undergoing scheduled coronary angiography or angioplasty. Participants will be assigned to listen to calming sounds, experience a virtual reali…

This study looks at whether 12 virtual health coaching sessions over 16 weeks can help people with heart disease (like heart failure or a heart attack) improve their health, reduce stress, and lower the chance of going back to the hospital. About 70 adults will take part, and the…

This study tests whether injecting a local anesthetic near the stellate ganglion in the neck, guided by ultrasound, can improve how patients feel after heart surgery. The block temporarily calms part of the nervous system, which may reduce pain, improve sleep, and lower the risk …

This study tests whether applying heat to the legs for 90 minutes each day at home can improve walking distance and leg function in adults over 50 with peripheral artery disease (PAD). Participants are randomly assigned to receive either active heat therapy or a sham (low-heat) v…

This study tests whether wearing eye masks and/or earplugs at night can improve sleep quality and reduce delirium in 128 patients recovering from coronary artery bypass surgery. Participants will be randomly assigned to use these aids on the first three nights after surgery. Rese…

This study tests whether a common water pill (furosemide) can help women with severe preeclampsia recover faster after childbirth and leave the hospital sooner. About 186 women will receive either furosemide or a placebo starting 12 hours after delivery. The goal is to see if the…

This study tests whether a short, supervised handgrip exercise program is practical and enjoyable for older adults (65+) with high blood pressure. Thirty participants will do handgrip exercises twice a week for 4 weeks. Researchers will check if the program is easy to stick with …

This study tests whether injecting a long-acting numbing medicine (bupivacaine) through chest tubes can safely reduce pain and lower the need for strong painkillers after heart bypass surgery. Sixty adults will receive either the numbing medicine or a saltwater placebo whenever t…

This study tests whether eptinezumab, a drug used for migraines, can reduce the number of headache days in adults with idiopathic intracranial hypertension (IIH), a condition where high fluid pressure around the brain causes severe headaches. About 96 women aged 18-55 with chroni…

This study tests whether using mild electrical pulses on the diaphragm and belly muscles can improve breathing, heart function, and exercise ability in people who recently had a heart artery-opening procedure (angioplasty). 42 adults will receive either standard rehab plus this s…

This study tests whether a virtual reality (VR) program that combines special sounds, lights, and real-time body feedback can lower stress and improve heart health markers in 40 adults visiting a cardiology clinic. Participants will be randomly assigned to VR, a non-VR relaxation…

This small pilot study will test a brief online mindfulness program (B-MORE) in 20 adults with high blood pressure and chronic stress. Participants attend two 60-minute virtual group sessions to learn stress management techniques. The study aims to see if the program is feasible …

This study compares two blood pressure medications, amlodipine and a purer version called levamlodipine, to see which causes less ankle swelling in post-menopausal women. About 344 women aged 50-79 with mild to moderate high blood pressure will take a daily pill for 18 weeks. Doc…

This study tests whether using the Replexa+ device twice daily for 3 months can improve blood flow in the lower legs and feet of veterans with peripheral artery disease (PAD) and peripheral neuropathy. Ten participants will have their blood flow measured before and after treatmen…

This study compares three pain management approaches for 120 adults undergoing coronary artery bypass surgery: standard painkillers alone, standard plus a parasternal nerve block, or standard plus both parasternal and adductor canal blocks. The goal is to see if adding these nerv…

This study tests whether low-intensity focused ultrasound (LIFU) applied to a nerve cluster in the neck can improve sleep quality and heart rate control in people recovering from heart surgery. 200 participants will receive either real or sham ultrasound daily for 3-7 days after …

This study tests whether adding the drug dexmedetomidine during carotid artery surgery helps keep blood pressure more stable. About 44 adults having this surgery will be randomly assigned to receive either standard anesthesia alone or standard anesthesia plus dexmedetomidine. The…

This study tests whether a simple self-acupressure routine can help lower blood pressure and reduce stress in people with high blood pressure. Seventy-two adults with primary hypertension will be split into three groups: real acupressure, sham (fake) acupressure, or usual care. T…

This study tests whether a 24-week recreational team handball program can improve walking ability and overall health in 60 men aged 60-80 with peripheral artery disease (PAD) and leg pain when walking. Participants will be randomly assigned to either the handball program or usual…

This study compares two types of exercise—elliptical training and Swiss ball aerobics—to see which better helps people recover after heart bypass surgery (CABG). Researchers will measure improvements in walking ability, heart rate, shortness of breath, and quality of life. The st…

This study tests whether one session of laser acupuncture can lower blood pressure in people with hypertension who are on hemodialysis. Researchers will measure blood pressure changes in 60 adults aged 18-65. The goal is to find a non-drug way to help manage blood pressure during…

This study tests whether adding a special breathing exercise device (IMT Threshold) to standard rehab can help people recover faster after coronary artery bypass graft surgery. The goal is to reduce time in the hospital and prevent serious breathing complications like pneumonia. …

This study tests whether a structured nursing program—including education, emotional support, and follow-up calls—can help heart bypass patients and their caregivers adapt better during recovery at home. About 40 adults who recently had heart surgery and their primary caregivers …

This study looks at how a cannabis-based drug (Dronabinol) affects blood pressure and heart function. Researchers will measure blood pressure, heart rate, and nerve activity in 50 healthy adults aged 21-40 who use cannabis occasionally. The goal is to see if cannabis can help man…

This study will test whether a single dose of beetroot juice can improve blood pressure and heart rate recovery after light cycling in adults with type 2 diabetes. About 20 participants aged 40-65 will receive either beetroot juice or a placebo in random order. The goal is to see…

This study tests if a new flexible cable (SuperCable) is better than standard steel wire for closing the breastbone after heart surgery. About 86 adults will be randomly assigned to one method. The goal is to see if SuperCable leads to faster bone healing, less pain, and shorter …

This study tests whether a 16-week home exercise program can improve daily function in 30 adults with pulmonary hypertension linked to interstitial lung disease. Participants will receive daily texts or emails with aerobic and strength exercises. Researchers will measure changes …

This study tests a device called Nanodropper that attaches to eye drop bottles and makes each drop smaller. Many glaucoma patients have trouble getting drops into their eyes or use too much, wasting medication. The trial will see if the device helps patients finish their bottles …

This study tests whether foot massage or kinesio taping can help older adults (65+) move better and feel less afraid of movement after heart surgery. Sixty participants will receive one of the two treatments daily for a week. Researchers will measure mobility, pain, and fear of m…

This study tests a hybrid cardiac rehabilitation program for people with peripheral artery disease (PAD), a condition that reduces blood flow to the legs and causes pain while walking. The program combines in-person supervised exercise sessions with home-based telerehabilitation …

This study looks at whether beetroot juice can quickly lower blood pressure in pregnant women with pre-eclampsia, a serious condition causing high blood pressure. Researchers will give beetroot juice or a placebo to 60 pregnant women and measure changes in blood pressure, blood m…

This study tests if laser acupuncture can improve arterial stiffness in people with cardiorenal metabolic syndrome (CRMS), a condition linking heart, kidney, and metabolic diseases. 35 adults with at least two of these conditions will receive laser acupuncture on their legs for 1…

This study looks at whether a back massage with mentholated ointment (like Vicks) can lower pain and anxiety in people who just had coronary bypass surgery. 120 adults will be split into three groups: one gets a back massage with mentholated ointment, one gets a back massage with…

This study looks at whether people with a moderate-risk blood clot in the lungs can be safely treated at home instead of staying in the hospital. About 568 adults will be randomly assigned to either go home early or receive standard hospital care. The goal is to see if home treat…

This study looks at whether a supplement called Neurofast® can help people who have both anxiety and heart problems. 80 adults aged 18-70 will take the supplement or no extra treatment for 12 weeks. Researchers will measure changes in anxiety, heart rate, and blood pressure.

This study tests whether a personalized AI-generated video, delivered by a nurse avatar, can improve recovery for people after coronary artery bypass surgery. About 128 patients will either get standard discharge instructions or the AI video plus standard care. Researchers will m…

This small pilot study will test two common blood pressure medicines—nicardipine and sodium nitroprusside—in 12 patients with acute respiratory failure and high blood pressure. Researchers will use a special imaging technique called electrical impedance tomography to see how thes…

This study explores whether measuring how a woman's pupils react to light before spinal anesthesia can predict dangerous drops in blood pressure during planned cesarean sections. Researchers will observe 200 healthy pregnant women and track their pupil responses and blood pressur…

This study tests whether a large language model (LLM) — a type of AI — can help village doctors make better care plans for patients with type 2 diabetes and high blood pressure. About 20 rural doctors will review standardized patient cases, with half receiving AI-assisted decisio…

This study uses advanced 4D MRI scans to measure blood flow and heart function in adults with heart disease or cancer. Researchers aim to see if these detailed images can help predict how these diseases will progress. The study involves 1,000 participants who are already schedule…

This study screens adults aged 18 and older in suburban and peri-urban areas of Faisalabad, Pakistan, for four major noncommunicable diseases: diabetes, hypertension, obesity, and high cholesterol. Participants who are found to have these conditions are referred to doctors for st…

This study follows 3,000 adults in Qatar—both citizens and long-term residents—to track how cardiometabolic conditions like diabetes and heart disease develop over time. Participants are grouped by blood sugar status (normal, pre-diabetes, or diabetes) and monitored for major car…

This study gathers data from 392 adults with heart failure who need a right heart catheterization. Researchers will use the data to train a machine learning model for a non-invasive device that estimates heart pressure. The goal is to help doctors monitor and treat heart failure …

This study follows 25,000 people referred to a specialized heart clinic with symptoms like chest pain or shortness of breath. Researchers will track which heart conditions are actually diagnosed and how patients are evaluated. The goal is to improve diagnostic accuracy and unders…

This study looks at why people with end-stage kidney disease on dialysis often develop high blood pressure in the lungs (pulmonary hypertension). Fluid buildup can make this condition seem worse than it is. Researchers will first correct fluid levels, then use heart ultrasound an…

This study will follow 5,500 first-time pregnant women to see if blood tests and eye scans can predict complications like preeclampsia, fetal growth restriction, and gestational diabetes. Researchers will collect samples and images at different points during pregnancy and compare…

This study will follow 100 adults whose high blood pressure remains high despite taking at least two medications. Over three months, researchers will track changes in blood pressure and other health markers to find patterns that could help identify which patients might respond be…

This study will check blood pressure and ask about health habits in 500 adults who attend free public health screenings in Croatia. Researchers want to see how many people have high blood pressure, how many know they have it, and how many are taking medicine for it. No treatments…

This study will interview 15 people from ethnic minority backgrounds in the UK who have heart disease. The goal is to understand their views on the diet and lifestyle advice they get from doctors, and whether it fits their cultural and religious customs. Researchers hope to learn…

This study will test whether using ultrasound to guide how a patient's head is tilted can improve blood flow to the brain. Researchers will measure brain pressure and blood flow in 30 ICU patients as they are moved from lying flat to a 30-degree angle. The goal is to find a perso…

This study checks whether an Apple Watch Series 9 can accurately measure key health indicators—like oxygen levels and exercise capacity—in adults with heart conditions such as congenital heart disease, heart failure, or coronary artery disease. Participants wear the smartwatch du…

This study tests a decision aid for people who have had a first blood clot and must decide whether to stop or continue blood thinners after at least 3 months of treatment. The aid provides balanced information on risks and benefits and helps clarify personal values. Researchers w…

This study is creating a large collection of blood samples and medical information from 1000 adults with or suspected of having pulmonary hypertension (PH). Researchers hope this resource will help them find new ways to diagnose and treat PH. Participants will provide a blood sam…

This study will look at 60 adults with a type of high blood pressure in the lungs (pre-capillary pulmonary hypertension) to see if measurements from a CT scan match those from a standard invasive heart catheter test. If the CT scan proves reliable, it could offer a safer, less in…

This study looks at whether a hospital rehab and prosthetic training program helps people who lost a leg due to diabetes or blood vessel disease use their artificial limb regularly. Researchers will review past patient records and follow new patients for up to 6 months after they…

This trial tests whether remifentanil or esmolol is better at preventing dangerous pressure spikes in the brain when a breathing tube is inserted. Patients with unruptured brain aneurysms scheduled for coil embolization will receive one of the two drugs before intubation. Researc…

This observational study will follow 2,352 adults with coronary heart disease to see how factors like blood sugar, sleep, and heart imaging relate to thinking and memory problems. Participants will take memory tests and undergo scans and blood work during a hospital stay. The goa…

This study looks at how the sedative dexmedetomidine affects the smallest blood vessels in people with septic shock, a life-threatening condition caused by severe infection. Researchers will measure blood flow in the tongue's tiny vessels and other key blood pressure indicators b…

This study tests whether it is possible to run a larger trial comparing two ways of using a breathing machine (ventilator) in critically ill heart patients who need help breathing. The two modes are volume-controlled (delivers a set amount of air each breath) and pressure-control…

This study surveys doctors who use Concerto Versa detachable coils to treat various blood vessel conditions like aneurysms and varicose veins. About 30 patients will be included, and doctors report how well the coils work and any problems within 72 hours. The goal is to collect e…

This study will collect data from 624 patients in respiratory intermediate care units (RICUs) across Catalonia to build a model that predicts 30-day survival. Researchers will also test an artificial intelligence approach and create a quick app for doctors. The goal is to better …

This pilot study will use special PET/CT scans to see how the experimental drug sotatercept affects blood vessel remodeling in the lungs and heart of people with pulmonary arterial hypertension (PAH). About 15 adults with PAH will receive sotatercept and have imaging at the start…

This study will use a special scan to look for B cells (a type of immune cell) in the blood vessels of 30 people with giant cell arteritis, a serious disease that can cause blindness or stroke. Current treatments rely on steroids, which have harsh side effects. If the scan works,…

This study looks at 150 adults having coronary bypass surgery to find out how often hidden heart injury occurs. Researchers use a sensitive blood test (troponin) and heart MRI to detect damage that standard tests might miss. The goal is to improve diagnosis and long-term care aft…

This observational study at a French hospital will ask 20 heart rehab patients and their care teams about what stops them from getting or offering psychological and social support. The goal is to understand these barriers so that hospitals can better help patients return to work …

This study looks at whether mindfulness-based stress reduction can help Black teenage girls who have been involved with the justice system and their parents or caregivers. About 90 participants will report on stress, PTSD symptoms, and other outcomes before and after the program.…

This study will follow 600 adults having off-pump heart bypass surgery to see how often memory and thinking problems occur afterward. Participants take a simple thinking test before and after surgery. The goal is to understand what factors might increase the risk of these problem…

This study is creating a decision aid for people with a rare heart condition called right anomalous aortic origin of a coronary artery (R-AAOCA). The condition raises the risk of sudden cardiac death, but the best management—surgery or careful observation—isn't clear. The aid wil…

This study will observe 110 adults having planned heart bypass surgery. Researchers will record settings on the breathing machine during surgery and check if patients develop lung complications like pneumonia or need a breathing tube for too long. No new treatments are given—the …

This study aims to see if a quicker MRI scan can produce images of blood vessel walls that are just as good as the standard, longer scan. Researchers will enroll 15 adults who already need a vessel wall MRI as part of their care. The faster scan will be compared to the regular on…

This observational study will look at how exercise changes blood flow in the legs of people with or at risk for peripheral arterial disease (PAD). About 85 participants will walk for 6 minutes and have their ankle-brachial index (ABI) measured before and after. The goal is to see…

This study looks at whether placing patients face-down (prone) soon after heart surgery can improve how well the right side of the heart works. The idea is that this position helps open up collapsed parts of the lungs, making it easier for the heart to pump blood. About 80 adults…

This study will test two new non-invasive devices (HEMI and SPG-NINOX) that measure small blood vessel function in 165 adults. Participants include healthy volunteers and people with high blood pressure, type 2 diabetes, or chronic kidney disease. The goal is to see if these devi…

This study looks back at medical records of 850 patients aged 80 and older who had a heart stent procedure at a UK hospital over seven years. Researchers will describe the patients' health, age, and frailty, and track complications like heart attack, stroke, or death up to one ye…

This study will examine how the heart-lung machine used during cardiac surgery changes platelet function and metabolism. Researchers will take blood samples from 100 adult heart surgery patients at several time points. The goal is to link these platelet changes to post-surgery in…

This study looks at whether allied-health professionals (like pharmacists or nurses) can help recruit and follow women who had preeclampsia during pregnancy. Participants will check their blood pressure at home and work with a research pharmacist for 12 months. The goal is to see…

This study will create a computer tool to predict which older adults are at high risk for serious problems after heart or blood vessel surgery. It will also test if special programs before and during surgery can help prevent confusion, heart issues, and death. About 1,200 people …

This study will follow 500 people with severe aortic stenosis who need a heart valve replacement. Researchers want to see if a dedicated Heart Valve Unit—a team of heart specialists working together—can reduce confusion, delirium, and memory problems that sometimes happen after t…

This study tests two strategies for removing an external ventricular drain (a tube that drains fluid from the brain) in 170 adults who had a brain bleed. One method clamps the drain shut as soon as it's safe, while the other gradually raises the drain over time. The goal is to se…

This study looks at how blood test results change after delivery in people with severe preeclampsia. Participants are randomly assigned to receive magnesium for either 12 or 24 hours after birth. The goal is to see if a shorter treatment is safe and effective, and to understand h…

This registry will follow 400 people with complex aortic aneurysms who are treated with GORE devices that help keep blood flowing to vital organs. The goal is to see how well the devices work and how safe they are in everyday medical practice. Participants must need at least one …

This study looks at whether a routine blood test (RDW) can help doctors quickly identify how well the heart and lungs are working together in people with a sudden lung clot (pulmonary embolism). Researchers will measure RDW and compare it to an ultrasound measure of heart-lung co…

This study will compare two common types of heart valves used in TAVI (a procedure to replace a narrowed aortic valve) to see which one sends fewer tiny particles to the brain during the procedure. 80 adults with severe aortic stenosis will be randomly assigned to receive either …

This study looks at how people with slightly high blood pressure react to salt. Participants will eat both high-salt and low-salt meals to see if their blood pressure changes. The goal is to find out who is salt-sensitive and who is not. No new treatments are tested—just careful …

This study will follow 600 adults who have had a stent placed or bypass surgery for coronary artery disease. Researchers will collect medical information, blood samples, and traditional Chinese medicine symptoms over 12 months. Using artificial intelligence, they aim to create a …

This study will follow 1,000 adults having a routine diagnostic endoscopy (camera test of the stomach or colon) with propofol sedation. Researchers want to find out which patients are more likely to have a dangerous drop in blood pressure or oxygen levels during the procedure. Th…

This study tests two different computer alerts designed to encourage doctors to refer heart patients to cardiac rehab. About 7,000 adults who had heart surgery or a stent in the past year will take part. The goal is to see if these simple reminders increase the number of people w…

This study aims to find out how often people with FLNA gene mutations develop emphysema, a type of lung disease. Researchers will use chest CT scans, blood tests, and lung function tests in 70 participants. The goal is to confirm if FLNA changes are a cause of unexplained emphyse…

This study adapts and tests a Spanish version of eTIPS, an early home-based therapy program for infants at risk of unilateral cerebral palsy after perinatal stroke. The program involves parent-delivered activities integrated into daily routines. The study will enroll 20 families …

This study compares how much radiation doctors are exposed to during heart procedures (PCI) when using the left distal wrist versus the right wrist for artery access. About 748 patients scheduled for PCI will take part. The goal is to see if the left wrist approach reduces radiat…

This study will follow 5,500 people in China who receive new heart valve devices (replacement or repair) for conditions like aortic stenosis or mitral regurgitation. Researchers will track safety issues such as stroke, bleeding, and device function over time. The goal is to see h…

This study looks at whether a new province-wide electronic health record system (called Connect Care) improves outcomes for adults with chronic diseases like diabetes, heart failure, or kidney disease. Researchers will compare hospital readmission and death rates before and after…

This study looks at two common anesthetics used during carotid artery surgery to see which one better protects the brain from small areas of damage. About 160 adults having planned carotid surgery will get either an intravenous or inhaled anesthetic. Researchers will compare brai…

This study looks at how metabolic health (measured by a simple blood test) relates to artery stiffness and daily blood pressure changes in 800 adults. Researchers will use routine tests and non-invasive measurements to find better ways to identify people at higher risk for heart …

This study will use heart scans and blood tests to check for early signs of heart disease in 650 adult survivors of childhood cancer. The goal is to better understand who is at highest risk due to past cancer treatments like radiation or chemotherapy. Results will be compared to …

This study looks at 1,300 people with moderate-risk pulmonary embolism (blood clots in the lungs) to compare three treatments: blood thinners, clot-busting drugs, and mechanical clot removal. Researchers will track deaths, heart recovery, bleeding risks, and quality of life over …

This study will measure eye pressure in one person with mild keratoconus before and one month after corneal cross linking. The goal is to see how the treatment changes eye pressure using a special device called Corvis CT. This is an observational study, not a treatment trial.

This study looks at 1,000 adults who had planned heart bypass surgery. Researchers will review existing hospital records to see if changes in routine blood tests (like inflammation and kidney markers) in the first hours after surgery can identify patients at higher risk for compl…

This pilot study tests whether a larger trial comparing two methods of harvesting the left internal mammary artery (LIMA) for heart bypass surgery is feasible. About 35 adults having planned bypass surgery will be randomly assigned to either the skeletonized method (isolating the…

This study tests whether using a CT scan to plan a heart stent procedure (PCI) makes it faster, safer, and more effective than the usual approach. About 200 adults with coronary artery disease will either get CT-guided planning or standard care. Researchers will compare procedure…

This early-stage trial will test a new tablet that combines two common drugs—one for type 2 diabetes and one for high blood pressure—in healthy volunteers. The goal is to see if the single pill works the same in the body as taking the two drugs separately. Thirty-six healthy adul…

This study compares three methods of measuring pulse wave velocity, a key indicator of artery stiffness that helps predict heart risk. Researchers will enroll 350 adults with high or uncontrolled blood pressure. Participants will have measurements taken with a neck-and-groin sens…

This study will examine 250 adults with chest pain but no major blockages in their heart arteries (a condition called INOCA). Researchers will collect cells from the heart's blood vessels during a standard angiogram and track symptoms, activity, and function over one year using q…

This early-stage study will test a new experimental drug called AD-231 in 60 healthy adults. The goal is to see how safe the drug is and how the body processes it, not to treat any disease. Participants will receive a single dose of the drug and have their blood levels measured o…

This study will follow 1000 adults in China with severe coronary artery disease who are too high-risk for bypass surgery and need complex angioplasty. Researchers will collect data on their health, procedures, and outcomes for one year to see what factors affect survival and comp…

This study follows 2,500 adults in Mexico aged 18 to 65 who do not yet have type 2 diabetes or high blood pressure. Over five years, researchers will track their health through yearly check-ups, blood tests, and lifestyle questionnaires. The goal is to identify what factors incre…

This study will test whether a special ultrasound score, called OTUS, can accurately track disease activity in people with Takayasu arteritis, a rare condition that causes inflammation of the large arteries. Researchers will follow 100 patients with active disease, performing ult…

This observational study will track 87 people who are already scheduled to receive treatment with the Recana Thrombectomy Catheter System for blocked veins in their legs. The goal is to see how safe the device is and how well it works at clearing the blockages during the procedur…

This observational study in Mexico will follow 30 adults already taking tirzepatide for conditions like diabetes or obesity. Researchers will use MRI scans of the knees, CT scans of the heart, and body composition tests to see how the drug affects cartilage, heart fat, and overal…

This study compares two methods of accessing the brachial artery in the arm for treating blocked leg arteries: a needle poke through the skin (percutaneous) versus a small cut (open). About 246 adults will be randomly assigned to one method. The goal is to see which approach caus…

This study will collect information on 1,200 emergency intubations across multiple hospitals in Taiwan. Researchers will track how often the tube is placed correctly on the first try and how often serious problems like low oxygen, low blood pressure, or cardiac arrest occur. The …

This study looks at how a long-acting injectable HIV prevention drug (CAB-LA) and hormonal birth control methods (like the shot or implant) affect each other in women. About 105 women who already use CAB-LA or no HIV prevention will join groups based on their contraceptive choice…

This study looks at 50 adults with acute pulmonary embolism (a blood clot in the lungs) to compare different methods used to diagnose and predict outcomes. Researchers will analyze clinical scores, lab tests, and CT scans from patients in various hospital departments. The goal is…

This study watches babies under 3 months old who are having surgery to fix a narrowed heart artery. Doctors will check if a special monitor that measures blood flow matches other standard checks. No extra treatments or changes to care are involved.

This study in Côte d'Ivoire tests whether giving mothers a cash reward for breastfeeding until their child is 24 months old increases breastfeeding rates and improves child and maternal health. About 1,040 mothers will either receive the cash incentive or just educational materia…

This observational study will follow 3000 patients with severely calcified coronary arteries who undergo a procedure to open the blockages (PCI). Researchers will track outcomes like heart attacks and repeat procedures over time. The goal is to learn which techniques work best in…

This study will use AI-guided CT scans to look for signs of heart disease in 100 former high-intensity athletes, like NFL alumni or Division I players, aged 30 and older. The goal is to find out how common coronary artery disease is in this group and understand the types of plaqu…

This study compares three ways of teaching midwifery students about preeclampsia and eclampsia: a digital game, a simulation, and traditional lectures. The goal is to see which method boosts knowledge, motivation, and attitude the most. 120 fourth-year midwifery students will tak…

This study will create and test a new questionnaire to measure quality of life in Chinese patients with pulmonary arterial hypertension (PAH), a serious lung condition. Researchers will work with 300 adults to ensure the tool is accurate and useful for doctors and health policy. …

This study aims to find early signs of diseases like heart disease, diabetes, and cancer by analyzing blood samples over time. Researchers will collect health data and blood from 15,000 adults aged 40-70 to create personalized health baselines using artificial intelligence. The g…

This study watches 100 adults with severe pulmonary embolism (blood clots in the lungs) during a procedure to remove the clots. The goal is to learn when and why heart or breathing problems happen during the procedure, so doctors can better prevent them and improve patient safety…

This study looks at whether adding a special heart function test (coronary function testing) to the standard artery-opening procedure (angioplasty) can better relieve chest pain and improve quality of life. About 450 adults with a significant blockage in a major heart artery will…

This study will measure the thickness of the carotid artery wall in 100 adults on hemodialysis. The goal is to see how traditional heart risk factors (like high blood pressure and diabetes) and dialysis-specific factors (like treatment length) relate to artery thickness. No new t…

This study will follow up to 12,750 stroke patients in Germany to learn how care is given from the moment symptoms start through hospital treatment, rehab, and long-term recovery. It includes both adults and children with ischemic stroke or brain bleeding. The goal is to collect …

This study will measure how eye pressure changes after common laser vision correction surgeries like PRK, LASIK, and femtosecond laser. Researchers will compare two measurement methods—Corvis CT and the standard applanation tonometer—in 50 people aged 19 to 35 with mild to modera…

This pilot study will test whether a women-focused education program, called Cardiac College for Women, helps women with heart disease learn more about their condition and feel better. About 50 women in cardiac rehab across Canada will either get the program plus usual care or us…

This study will follow 1,000 children under 18 who have had a stroke to see which treatments work best in everyday hospitals. Researchers will check their recovery, brain scans, and daily life over 6 months. The goal is to learn what helps children recover the most after a stroke…

Stanford University is enrolling 50 adults aged 18–64 to collect vital signs using a blood pressure cuff, EKG, and PPG. The goal is to use this data to develop a noninvasive, continuous blood pressure monitoring device that could replace traditional cuffs. This is an observationa…

This study will look at how consistently nearly 6,000 adults in Italy take three newer cholesterol-lowering drugs (inclisiran, evolocumab, and alirocumab) over the long term. Researchers will analyze prescription records to measure adherence and persistence in everyday medical pr…

This study from the University of Oxford will follow 360 pregnant women to see if hormone levels and ultrasound images from the first 8 weeks can predict pre-eclampsia. Pre-eclampsia is a dangerous complication that affects many pregnancies worldwide. The goal is to find early wa…

This study observes 600 people with aortic stenosis who cannot have a standard TAVI procedure through the leg artery. Instead, doctors will use other access points, like the chest or neck, to replace the heart valve. The goal is to track safety and success rates of these alternat…

This study tests whether giving primary care doctors detailed feedback on how well they follow treatment guidelines can improve care for patients with high blood pressure and type 2 diabetes. Researchers will enroll 324 healthcare providers in Nepal, Mozambique, Tanzania, and Chi…

This study looks at 70 children and teens with juvenile lupus to check for early signs of heart disease using an ultrasound of the neck artery. Researchers will see if things like cholesterol, blood pressure, and lupus activity are linked to artery thickness. No treatment is give…

Severe preeclampsia is a dangerous pregnancy complication that can cause high blood pressure, harming both mother and baby. This observational study will follow 350 women to identify factors that make blood pressure control with the drug labetalol fail. By understanding these fac…

This study looks at whether placing a catheter in a neck vein changes pressure inside the skull. Researchers will use ultrasound to measure the optic nerve sheath and carotid artery in 61 adults under general anesthesia. The goal is to understand short-term effects, not to test a…

This study looks back at medical records of 105 people who had a minimally invasive surgery called BEVAR to treat complex aortic aneurysms. Researchers want to see if two types of stent grafts (TUVA BX and iCover) are safe and work well. No new treatments are given; the study jus…

This study tests whether evolocumab, a drug that lowers 'bad' cholesterol, changes the cells in the wall of an abdominal aortic aneurysm. About 44 people scheduled for aneurysm repair will receive either the drug or a placebo before surgery. Researchers will then compare the tiss…

This observational study will test whether a 1-3 minute AI-powered facial scan can accurately measure vital signs like heart rate and blood pressure, as well as estimate blood sugar, cholesterol, and mental health status. Researchers will compare the scan results with standard me…

This study will test a new type of CT scan (photon counting CT) to see if it can give doctors a clearer picture of the fatty deposits (plaques) inside heart arteries. The goal is to find out if these detailed images can help predict who might have a heart attack or other serious …

This study looks at whether people who have had a ruptured brain aneurysm also have an abdominal aortic aneurysm (a bulge in the main belly artery) that they don't know about. About 233 participants will get a painless belly ultrasound to check. The goal is to see how common this…

This study looks at whether a cardiopulmonary exercise test (CPET) can help predict serious heart problems in people with coronary heart disease. Researchers will review medical records from 15,000 patients and track their health over time. The goal is to see if CPET results are …

This study follows 60 adults with pulmonary hypertension (high blood pressure in the lungs) for 2 years. Researchers will measure breathing problems during sleep and heart rate changes to see how they relate to the disease. No new treatment is given; participants continue their u…

This study tests a mobile health program called SAMU to help adults in Uganda who have HIV, high blood pressure, and mental health issues like depression or anxiety. About 1,500 participants will use their phones for mental health screening and get connected to care. The goal is …

The MISTIC study will examine 1000 adults to see if early, symptom-free artery disease is linked to thinking and memory problems. Participants will get non-invasive imaging of their arteries and cognitive tests. This is an observational study, not a treatment trial, aiming to imp…

This study will examine 108 adults aged 30-65 to see if a gene called Klotho, certain mouth bacteria, and viruses are linked to gum disease and acute coronary syndrome (a type of heart attack). Researchers will measure gum health and collect samples to look for these markers. The…

This study will follow 1,800 people who had a stent placed in their heart arteries using a special camera (OCT). Researchers want to see if new measurements from routine angiograms can better predict future heart problems like heart attacks or chest pain. The goal is to improve h…

This study looks at how ups and downs in blood sugar affect diabetic patients admitted to the coronary care unit. Researchers will track 120 adults with diabetes and heart disease to see if glucose variability increases the risk of death or major heart problems like heart attack …

This study looks at whether advanced heart pressure wave analysis can predict how well patients recover after a TAVR procedure for severe aortic stenosis. Researchers will measure pressure waves during the procedure and track quality of life and heart complications over one year …

This study looks at 212 heart disease patients who take antiplatelet drugs and have sudden upper stomach bleeding. It compares having an endoscopy within 12 hours versus waiting 12-24 hours to see which timing is safer and more effective. The goal is to find the best approach to …

This study works with 35 primary care clinics to help them screen patients for physical inactivity and refer them to community-based exercise programs. The goal is to see if this approach can be smoothly integrated into routine care and whether it leads to better health outcomes …

This study will check children under 18 with chronic liver disease for hidden heart problems. Doctors will use simple tests like ECG and ultrasound to look for issues such as abnormal heart rhythms or weakened heart muscle. The goal is to better understand how liver disease affec…

This study aims to understand how fat around the belly and heart relates to inflammation and early signs of heart disease, diabetes, and fatty liver. Researchers will enroll 400 adults without known heart or liver disease. Participants will undergo non-invasive tests like ultraso…

This study tests whether giving people with heart or lung conditions real-time air pollution data helps them exercise outdoors more safely. 80 participants will use a smartphone platform that tracks their walking and local air quality. The goal is to see if this approach reduces …

This study looks at 40 mothers and their 6-month-old babies to see if mindfulness training during pregnancy helps them handle stress better together. Researchers will measure heart rate and stress responses during a short separation-and-reunion task. They will then check if these…

This study will check if an ultrasound of the internal jugular vein in the neck can predict a sudden drop in blood pressure during spinal anesthesia for C-section in women with preeclampsia. Researchers will measure the vein's collapsibility before surgery and track blood pressur…

This observational study will follow 100,000 elderly Chinese adults (age 65+) to see how metabolic conditions like diabetes, high blood pressure, and high cholesterol impact the development and progression of chronic kidney disease (CKD). Participants will provide blood and urine…

This study looks at how changes in the cells lining blood vessels relate to lung resistance in people with pulmonary artery hypertension (PAH). Researchers will measure certain blood markers and lung pressure in 6 adults with PAH. The goal is to better understand the disease, not…

This study will follow 600 people who need either bypass surgery (CABG) or a stent (PCI) to open blocked heart arteries. Researchers will test memory and thinking skills before the procedure and again at 1 month, 1 year, and 2 years after. The goal is to see if one approach leads…