Arterial disorder

This large phase 3 trial tests whether newer blood thinner combinations (ticagrelor plus aspirin or rivaroxaban plus aspirin) are better than the standard clopidogrel plus aspirin at preventing stroke, brain bleeding, or death from blood vessel disease. Over 1,600 participants wi…

This study tests a drug called riociguat in children aged 6 to 18 who have pulmonary arterial hypertension (PAH), a condition where high blood pressure in the lungs makes it hard to breathe and move. The goal is to see if the drug is safe and how the body processes it at differen…

This study tests whether injecting botulinum toxin (Botox) into fat pads around the heart's veins during cardiac surgery can prevent atrial fibrillation (AFib), a common and serious complication. About 220 adults undergoing heart surgery will receive either Botox or a placebo inj…

This study tests a new drug called TS23, a monoclonal antibody designed to help break down blood clots in the lungs. It is for people with intermediate-risk pulmonary embolism, a serious condition where clots block blood flow. The trial compares different doses of TS23 against a …

This study tests two treatments for people with intermediate-high risk pulmonary embolism (a serious blood clot in the lungs). Half receive standard blood thinners, and the other half get blood thinners plus a special ultrasound device that helps dissolve the clot. Researchers wi…

This study tests whether a reduced dose of the clot-dissolving drug alteplase, given alongside standard blood thinners, can improve outcomes for people with intermediate-high-risk pulmonary embolism (a serious blood clot in the lungs). About 800 adults with confirmed acute pulmon…

This early study tests a new stent system designed to treat blockages at artery branch points in the heart. It involves 13 people with heart disease who need a procedure to open these blockages. The main goal is to see if the stent can be safely placed and work as intended.

This study is following 300 people with peripheral artery disease who received the MicroStent, a small mesh tube placed in leg arteries to improve blood flow. Researchers are tracking how well the arteries stay open over time and whether patients avoid major complications like am…

This trial tests two types of drug-coated balloon catheters to treat small, newly blocked heart arteries. About 180 adults with stable or unstable angina will be randomly assigned to receive one of the two devices during a standard angioplasty procedure. The goal is to see which …

This phase 3 study tests whether adding baxdrostat to the standard drug dapagliflozin can better slow chronic kidney disease (CKD) progression in adults with CKD and high blood pressure. About 2,500 participants will receive either the combination or dapagliflozin alone for 24 mo…

This study tests a new device called the DurAVR™ THV System, a replacement heart valve placed through a small tube in an artery, for people with severe aortic stenosis (a narrowed heart valve). The trial involves 150 participants and aims to see if the device is safe and works we…

This early study tests a new device called the DurAVR™ heart valve in 15 people aged 65 and older with severe aortic stenosis, a condition where the heart's aortic valve becomes narrowed. The valve is implanted through a catheter (TAVR) without open-heart surgery. The main goals …

This study tests a virtual clinic where pharmacists monitor blood pressure, adjust medications, and provide telehealth support to older adults (65+) with high blood pressure. The goal is to see if better blood pressure control can also help prevent cognitive decline. About 1,000 …

This study follows 284 people with blocked leg arteries (peripheral arterial disease) who are treated with a paclitaxel-coated balloon. The balloon is inflated inside the artery to open it and release a drug that helps prevent it from narrowing again. Researchers are tracking saf…

This study looks at how well Onyx drug-eluting stents work in everyday medical practice for people with coronary artery disease. Researchers will track 4,500 patients to see if these stents are safe and effective compared to other stents. The main focus is on preventing stent-rel…

This study tests whether inclisiran, a drug given as a shot every 6 months, can reduce plaque buildup in the heart's arteries when added to standard statin therapy. About 608 adults with mild artery blockages (less than 50%) and no prior heart events will be randomly assigned to …

This phase 2 trial tests whether adding the oral drug iptacopan to standard therapy (rituximab) helps people with active ANCA vasculitis achieve and maintain remission. About 84 adults with newly diagnosed or relapsed disease will receive either iptacopan or a placebo, plus stand…

This study tests a 12-week home-based digital program called eCardiacRehab for people who have had a heart procedure (PCI). The program includes video messages, modules, and tracking to support recovery. Researchers want to see if patients will use it regularly and find it accept…

This study tests whether taking 480 mg of magnesium glycinate daily for 12 weeks can lower blood pressure in adults with slightly high systolic blood pressure (130-159 mmHg). 120 participants will be randomly assigned to get the supplement or a placebo. The main goal is to see if…

This large study compared two treatments for severe aortic stenosis (a narrowed heart valve) in 1,746 patients at intermediate risk for surgery. One group got a less invasive procedure called TAVI (a new valve inserted through a tube in the artery), and the other had open-heart s…

This study looks at whether starting a cardiac rehabilitation programme soon after leaving the hospital helps people with coronary artery disease live longer and avoid hospital stays for heart problems. The programme includes counseling, education, and exercise sessions three tim…

This study looks at the long-term safety of an inhaled medication called seralutinib for people with pulmonary arterial hypertension (PAH), a serious condition where high blood pressure damages the arteries in the lungs. About 316 participants who finished a previous seralutinib …

This study tests two programs—mindfulness training and a heart-healthy diet plan—to help Black women caregivers lower their blood pressure and stress. About 90 participants will join weekly group sessions online for 8 weeks, with follow-up calls. The goal is to see if these appro…

This trial is testing a new heart valve called SAPIEN X4/X4S in over 1,200 people with severe aortic stenosis, a condition where the heart's aortic valve narrows. The valve is inserted through a catheter, avoiding open-heart surgery. Researchers are measuring how many patients di…

This large study looks at real-world data from 60,000 people with type 2 diabetes and obesity to compare four diabetes drugs—dulaglutide, semaglutide, tirzepatide, and sitagliptin—in preventing heart attacks, strokes, and death. Researchers are analyzing insurance claims to see w…

This study tests a special balloon coated with a drug to treat heart arteries that have narrowed again after a stent was placed. About 600 adults with this condition will be randomly assigned to receive either the drug-coated balloon or a standard balloon procedure. The goal is t…

This phase 2 trial tests an injectable drug called DII235 in 233 adults with high lipoprotein(a), a genetic condition that raises heart disease and stroke risk. Participants have heart disease or type 2 diabetes. The study compares different doses of DII235 against a placebo to s…

This early study tests a small, permanent device called the V-Wave Interatrial Shunt in 9 people with severe pulmonary arterial hypertension (PAH). The device is placed in the heart during a minimally invasive procedure to create a small opening between the upper chambers, which …

This study tests a special balloon coated with the drug paclitaxel to treat in-stent restenosis, where a previously placed stent in a heart artery narrows again. Twenty adults who have this condition will receive the balloon treatment or standard care. Researchers will check if t…

This large Phase 3 study tests an injectable drug called lepodisiran in about 17,300 adults with high levels of lipoprotein(a), a genetic risk factor for heart disease and stroke. Participants either already have heart disease or are at high risk for a first heart event. The goal…

This phase 3 trial is testing whether the drug retatrutide can lower the chance of serious heart problems (like heart attacks and strokes) and slow kidney disease in 10,000 overweight adults who already have heart or kidney disease. Participants receive either retatrutide or a pl…

This study tests whether home visits by female community health volunteers plus regular SMS messages can help adults in Pokhara, Nepal, better control high blood pressure, type 2 diabetes, and smoking. About 2100 participants are split into two groups: one gets the home visits an…

This early-stage study tests a new drug called ADX-850 in 28 people with mild to moderate high blood pressure. The drug uses siRNA technology to target genes involved in blood pressure regulation. The main goal is to check safety and how the drug moves through the body, with a se…

This early study tests a special scaffold that dissolves over time in 10 people with severe leg artery disease (critical limb-threatening ischemia). The scaffold is placed in arteries below the knee to help keep them open after balloon treatment. Researchers check safety and how …

This study tests a smartphone app called Liebria designed to help people manage high blood pressure. 328 adults with high blood pressure used the app at home to track and lower their readings. The goal is to see if the app can help control blood pressure and improve daily life.

This study planned to test whether giving a child their own stored umbilical cord blood is safe for treating perinatal arterial ischemic stroke. It was designed for children aged 6 weeks to 6 years with MRI-confirmed stroke. The trial was withdrawn before enrolling any participan…

This study tests a 6-month church-based program to help African Americans with uncontrolled high blood pressure. The program includes Bible study sessions led by the pastor and small group meetings focused on diet and exercise. A community health worker provides extra support if …

This study tests a new device that uses shock waves to break up calcium deposits in heart arteries before placing a stent. About 335 adults with coronary artery disease will receive this treatment at up to 55 US sites. The goal is to see if the device helps stents work better and…

This trial studies nearly 1,000 people with severe aortic stenosis and blocked coronary arteries who need both a valve replacement (TAVI) and artery stenting (PCI). Researchers want to see if doing the stenting before or after the valve replacement leads to fewer deaths, heart at…

This study tests a program where people with slightly high blood pressure use a home monitor and get support from a community health worker. The goal is to see if this helps keep blood pressure from rising to dangerous levels. About 600 adults from 20 health centers are taking pa…

This study tests whether adding an interleukin-6 receptor inhibitor (a drug that reduces inflammation) to standard emergency stroke treatment helps people recover better after a severe stroke caused by a large blood clot in the front part of the brain. About 692 adults who are el…

This study tests whether adding a specially trained doula, along with home blood pressure and weight monitoring, can improve blood pressure in women who had high blood pressure during pregnancy. About 454 women will be randomly assigned to usual care or the doula program. The goa…

This study follows 116 people with open-angle glaucoma who already have a MINIject implant in their eye. Researchers will track them for up to 5 years to see if any serious device-related problems occur. No new treatment is given—this is a safety check to see how well the implant…

This study compares two types of weight-loss surgery (gastric bypass and gastric banding) with an intensive diet and exercise program for controlling type 2 diabetes in moderately obese adults aged 25 to 55. The goal is to see which approach works best for improving diabetes and …

This study tests a special balloon catheter coated with the drug paclitaxel to treat narrowed or re-narrowed brain arteries. The balloon is inflated inside the artery to open it and release the drug, which may help prevent the artery from closing again. The trial includes 281 adu…

This study compares a new stent (Supera) to standard surgery for treating blockages in the leg's main artery. About 286 people with moderate to severe leg pain or sores will be randomly assigned to get either the stent or surgery. Researchers will check if the stent keeps the art…

This study tests whether a high-intensity statin and a low-dose anti-inflammatory drug (colchicine) can slow the buildup of artery plaque in people with a high genetic risk for heart disease. Researchers will use CT scans to measure changes in plaque over one year. The trial invo…

This trial tests whether a new device called OmniHeart 4.0 can safely support the heart during high-risk angioplasty, compared to the standard ECMO machine. About 254 patients will be randomly assigned to receive either the OmniHeart or ECMO. Researchers will track major heart an…

This study tests whether a new drug-coated balloon (Passeo-18 Lux) is as safe and effective as an existing one (IN.PACT Admiral) for opening blocked leg arteries in people with peripheral artery disease. About 302 participants with moderate to severe symptoms are randomly assigne…

This study tests whether Rhopressa eye drops can further lower eye pressure in people with glaucoma or high eye pressure who recently had laser surgery (SLT) in both eyes. About 70 adults will receive either Rhopressa or placebo drops daily for several weeks. The goal is to see i…

This large Phase 3 trial is testing whether a drug called inclisiran can reduce major heart problems like heart attacks and strokes in people who already have heart disease. About 17,000 participants are taking either inclisiran or a placebo, along with their usual cholesterol-lo…

This study tests a mobile app called HyperCoach that provides health coaching to help people with high blood pressure manage their condition. Thirty-seven adults with hypertension who are already on medication will use the app to track blood pressure, weight, and steps, and set p…

This study looks at the long-term safety of a drug called sotatercept for people with a specific type of pulmonary hypertension caused by heart failure with preserved ejection fraction. About 130 people who completed a prior study will receive sotatercept injections and be monito…

This study tests a next-generation heart valve (Navitor) in 333 people with severe aortic stenosis who are too high-risk for open-heart surgery. The goal is to see if the valve is safe and works well at 30 days, focusing on survival and reducing leaks around the valve. The valve …

This study tests a 3-month lifestyle program called the PILI Pasifika Program for Native Hawaiian and Pacific Islander adults who are overweight or have conditions like high blood pressure or diabetes. The program includes group lessons on healthy eating and physical activity, pl…

This study is testing the safety and right dose of a drug called selexipag in children aged 2 to 17 with pulmonary arterial hypertension (PAH), a serious condition where blood pressure in the lungs is too high. The goal is to find a dose that works like the adult version. The stu…

This phase 3 trial studies 1,200 people with severe coronary artery disease and a weak heart pump (ejection fraction 40% or less). Participants are randomly assigned to receive either guideline-directed medical therapy, bypass surgery, or stenting. The study tracks survival, hear…

This study tests whether adding selexipag to standard treatment can delay disease worsening in children aged 2 to 18 with pulmonary arterial hypertension (PAH). About 138 children will receive either selexipag or a placebo, plus their usual medications. The main goal is to see if…

This study tests a special stent device (GORE EXCLUDER) to treat thoracoabdominal and pararenal aortic aneurysms—bulges in the main artery that can rupture. About 102 people will receive the stent through a minimally invasive procedure. Researchers will check if the device is pla…

This phase 3 trial compares two doses of macitentan (75 mg vs 10 mg) in about 935 adults with pulmonary arterial hypertension. The goal is to see if the higher dose can delay serious events like hospitalization or death. Participants will be followed for several years.

This study tests whether using a special camera (OCT) inside the heart's arteries during a heart attack procedure leads to better outcomes than the standard X-ray method. About 3000 people having a heart attack will be randomly assigned to one of the two approaches. The goal is t…

This study looks at whether giving low-income people with diabetes or hypertension a monthly grocery card ($80 or $120) helps them control their disease and feel less stressed about food. About 4,450 adults in California are taking part. Researchers will check changes in blood su…

This study tests whether a natural supplement called nicotinamide riboside can improve artery stiffness and lower blood pressure in people with moderate to severe chronic kidney disease. About 118 adults aged 35-80 will take either the supplement or a placebo for 3 months. The go…

This study looks at whether providing medically tailored groceries can help people with type 2 diabetes and high blood pressure keep up healthy eating habits and control their blood sugar and blood pressure. About 80 adults who already took part in a meal delivery study will rece…

This study tests a special chimney graft technique for people with a type of aortic aneurysm that is hard to treat because it is close to the kidneys. The goal is to see if this method is safe and works well in everyday medical practice. About 150 adults will take part, and resea…

This study tests a nurse-led program that uses home monitoring devices to help older adults with conditions like heart failure, diabetes, and depression manage their health after leaving the hospital. The goal is to improve care coordination and reduce hospital readmissions. Abou…

This study tests whether a church-based program led by community health workers can help Black adults in Louisiana lower their risk of heart disease, high blood pressure, diabetes, and high cholesterol. About 812 participants from local churches will receive either a health worke…

This study tests whether sending primary care doctors a monthly report comparing their hypertension control rates to peers can improve patient care. About 93 doctors and their patients with high blood pressure are involved. The goal is to see if this feedback leads to more medica…

This study compares a new, less invasive shockwave device to standard surgery for treating severe calcium buildup in the main leg artery. The shockwave uses sound waves to break up the calcium, while surgery involves physically removing the blockage. Researchers want to see if th…

This study looks at whether giving people with PTSD a personalized mix of gut bacteria (called pharmabiotics) can help their mental health. The researchers will track changes in PTSD symptoms, anxiety, depression, and thinking skills over 14 days. The goal is to see if fixing the…

This study tests a program called PACE that combines nurse support, remote blood pressure monitoring, and help with social needs (like housing or food) to improve blood pressure control in Black patients. About 500 adults with uncontrolled high blood pressure will take part acros…

This study follows 600 Belgian adults with atherosclerotic cardiovascular disease who are prescribed inclisiran, a cholesterol-lowering injection, alongside their usual medications. Researchers will measure how much LDL cholesterol drops and how many patients reach their target l…

This study tests whether the antibiotic doxycycline can prevent or slow the enlargement of heart arteries in children with Kawasaki disease. About 26 children with already enlarged coronary arteries will receive doxycycline for three weeks. The goal is to see if the drug blocks a…

This phase 2b trial tests a weekly oral tablet called ecnoglutide (VRB-101) for weight loss in 206 adults with obesity or overweight plus weight-related health problems. Participants receive either the drug or a placebo for several weeks. The main goal is to see how much body wei…

This study tests an experimental drug called QCZ484, given as an injection under the skin every 6 months, for people with mild to moderate high blood pressure. About 385 adults aged 18 to 75 are taking part. The goal is to see if the drug safely lowers blood pressure compared to …

This study compares two types of TAVR devices (self-expanding vs. balloon-expandable) in over 1,100 people with severe aortic stenosis and a small aortic annulus. The goal is to see which device leads to fewer deaths, strokes, or hospitalizations, and which performs better over t…

This study tests whether monthly home visits from trained health agents can help people in poor, high-altitude communities in Peru better control their high blood pressure and diabetes. Over 1,000 participants will either receive these visits for a year or get usual care. The goa…

This study compares two strategies for placing stents in people with multiple blocked heart arteries. One group gets standard guidance using a pressure wire (FFR), while the other also uses an imaging catheter (OCT) to spot unstable plaques. The goal is to see if the combined app…

This study tests a special tube called a stent graft to repair damage in the upper part of the main artery from the heart (the ascending aorta). It is for people with bulges (aneurysms), tears (dissections), or other lesions that usually need open-heart surgery. The goal is to se…

This study tests whether a combination of high-dose statins, blood pressure medications (ACE inhibitors or ARBs), and low-dose aspirin can reduce the risk of death, heart attack, stroke, or hospitalization in women who have chest pain or shortness of breath but no major blockages…

This study compares two cholesterol-lowering strategies in adults aged 75 and older who have heart or blood vessel disease. One group aims for a very low LDL cholesterol target (below 55 mg/dL) using high-intensity statins, while the other receives standard moderate-intensity sta…

This Phase 3 trial tests a daily pill called orforglipron in 487 adults with high blood pressure who are also overweight or obese. The study measures how well the drug lowers blood pressure and body weight compared to a placebo. It is currently active but not recruiting.

This study tests whether inclisiran, a newer cholesterol-lowering drug, works better than standard treatments for Chinese patients with coronary heart disease. About 1,590 adults whose cholesterol is still high despite statins will receive either inclisiran or usual care. The mai…

This Phase 3 study tests an experimental once-daily pill called orforglipron in about 487 adults who have both high blood pressure and obesity or overweight. The main goal is to see if the drug lowers blood pressure more than a placebo. Researchers will also check for changes in …

This Phase 3 trial is testing a once-daily pill called orforglipron in nearly 1,000 people with high blood pressure who are also overweight or have obesity. The study compares the drug to a placebo to see if it safely lowers blood pressure. Participants may be untreated or on sta…

This study was designed to test a new surgical technique called transverse tibial bone transport in people with chronic limb-threatening ischemia (CLTI) who have no standard treatment options left. The procedure involves slowly moving a small piece of shinbone to stimulate new bl…

This early-phase study tests a single injection of ART101 in 16 adults with high blood pressure. The goal is to see if it is safe and how it affects blood pressure over 24 weeks. Participants receive either 600 mg or 800 mg of the drug and are closely monitored.

This study tests whether a drug-coated balloon is as safe and effective as a drug-eluting stent for people with large coronary artery disease. About 1,400 participants from multiple countries will be randomly assigned to one of the two treatments. The goal is to see which approac…

This study is testing the long-term safety and tolerability of an inhaled treprostinil powder (TPIP) in people with pulmonary arterial hypertension (PAH). About 91 participants who completed earlier TPIP studies will receive the drug for up to several years. Researchers will moni…

This study tests a health support program for 600 people with disabilities who also have chronic conditions like diabetes or obesity. The program includes weekly nutrition classes, three exercise sessions per week, and help managing chronic conditions. Researchers want to see if …

This study tests whether eye pressure-lowering medication can slow the progression of severe nearsightedness (high myopia) in adults. Researchers will measure changes in eye length and vision over time. The trial includes 152 participants aged 18 to 65 with worsening high myopia …

This study planned to test a special shockwave device that uses sound waves to crack calcium buildup in leg arteries before placing a stent. The goal was to improve stent fit and long-term blood flow in people with severe peripheral artery disease. However, the trial was withdraw…

This study looks at whether a special blood test (TEG-PM) can guide doctors in adjusting blood-thinning medications for people who have had leg artery surgery for peripheral artery disease. About 130 adults will have their blood tested before and up to 9 months after surgery, and…

This study follows 164 people with abdominal aortic aneurysm who receive the Ankura stent graft system, a device placed inside the aorta to reinforce the weakened area. Researchers will track major complications and treatment success over 12 months. The goal is to see how well th…

This study tests whether nurse-led health coaching can help adults with high blood pressure in Huayuan County, China, better manage their condition. About 78 participants will receive either standard care or additional coaching sessions over six months. The goal is to see if coac…

This study is following 147 people who have a bulge (aneurysm) or tear (dissection) in the main artery of the chest. All participants received the Ankura stent graft, a fabric-covered metal tube placed inside the artery to support it. Researchers are tracking how well the device …

This study looks at whether 10 weeks of regular exercise (on land or in water) can lower blood sugar and blood pressure in people aged 60 and older who have several health conditions like diabetes, high blood pressure, and arthritis. 63 volunteers will be split into two exercise …

This Phase 3 study tests a weekly injection called retatrutide in about 1,946 people with severe obesity (BMI ≥35) and established heart disease. The goal is to see if it helps with weight loss and improves heart-related health measures over 113 weeks compared to a placebo. Parti…

This study tests whether adding cabergoline to osilodrostat works better than osilodrostat alone for controlling Cushing's disease. About 50 adults with active Cushing's disease will receive either the combination or the single drug. The goal is to see if the combo can lower cort…

This study tests a new daily pill called QLS1410 in 260 adults whose high blood pressure remains high despite taking two or more medications. Participants will receive either QLS1410 or a placebo for 12 weeks. The main goal is to see if QLS1410 can lower systolic blood pressure m…

This trial tests a 12-month lifestyle medicine program for 1000 adults with obesity and related conditions like diabetes or high blood pressure. Participants get regular visits with a dietitian and a doctor, plus optional behavioral health support. The goal is to see if the progr…

This Phase 2 trial tests an inhaled drug called LAM-001 (sirolimus) in 85 adults who have pulmonary hypertension (high blood pressure in the lungs) along with interstitial lung disease (lung scarring). The study compares the drug to a placebo to see if it improves blood flow in t…

This study is testing a device that uses sound waves (intravascular lithotripsy) to break up hard calcium deposits in the heart arteries of women with coronary artery disease. The goal is to make it easier to place stents and improve outcomes. About 400 women are being followed t…

This study tests an implant called AGN-193408 SR that is placed inside the eye to lower pressure in people with open-angle glaucoma or ocular hypertension. About 100 participants will receive the implant, and some will also get standard eye drops for comparison. The goal is to se…

This study looks at whether switching to a plant-based diet can improve heart health and reduce inflammation in people who have had a kidney transplant. Twenty-five participants who are at least three months post-transplant will follow a plant-based diet for 16 weeks after a two-…

This study tests whether the drug APX-115 can prevent kidney injury caused by contrast dye used in heart procedures. About 230 adults with kidney disease will receive either the drug or a placebo before and after their procedure. The goal is to see if the drug reduces kidney dama…

This study tests whether a less invasive heart valve replacement (TAVR) is safe and effective for people with moderate aortic stenosis, a condition where the heart's aortic valve is partially blocked. About 650 participants will receive the TAVR device and be monitored for compli…

This study tests a new laser procedure called Direct Selective Laser Trabeculoplasty (DSLT) in 40 ethnic Chinese patients with glaucoma or high eye pressure. The laser aims to improve fluid drainage in the eye and reduce pressure. Researchers will check if the treatment is safe a…

This study compares two procedures for severe aortic valve stenosis: transcatheter aortic valve implantation (TAVI), a less invasive approach, and standard open-heart surgery. It will follow 4,000 high-risk patients for up to 24 months to see which method leads to fewer deaths, h…

This early-stage study by Pfizer tests a new drug called PF-07868489. First, it will be given to healthy volunteers to check safety and how the body processes it. Then, people with pulmonary arterial hypertension (PAH) will receive repeated doses over 24 weeks to see if it helps …

This study tests whether a weekly injection of CagriSema (a combination of two drugs) can reduce the risk of heart attacks, strokes, and other heart-related events in people with established cardiovascular disease. About 7,100 participants will receive either CagriSema or a place…

This early study is testing a device that uses ultrasound to ablate (calm) nerves in the pulmonary artery. The goal is to see if this procedure can improve quality of life for 50 people with heart failure and a specific type of pulmonary hypertension (Group 2). Participants will …

This study tests a device called TIVUS that uses ultrasound to calm overactive nerves in the kidneys, which can drive high blood pressure. It includes 25 adults with uncontrolled stage 2 hypertension who have not responded well to medication. The main goal is to see if the proced…

This study compares two ways to place stents in the left main coronary artery when there is a blockage at the opening of a branch. One method places a stent only in the blocked branch, while the other extends a stent from the main artery into the branch. Researchers will track 10…

This study looks at different methods to help patients with high cholesterol and heart disease get the right medicines to lower their cholesterol. About 300 adults at high risk will take part. The goal is to see which approach helps more people reach their target LDL cholesterol …

This study tests whether using a special imaging tool called OCT during stent placement leads to fewer heart problems over two years compared to standard methods. About 1,200 adults with blocked heart arteries that need complex stenting are taking part. The goal is to see if OCT …

This study tests whether whole-body electromyostimulation (WB-EMS), a technology that stimulates muscles with mild electrical pulses, can lower resting blood pressure and improve other heart risk factors in overweight adults aged 50+ with mild hypertension. Over 12 weeks, 28 part…

This study tests whether a probiotic called Limosilactobacillus fermentum CRL 1446 can improve health in 80 adults with heart disease risk factors like obesity, high blood pressure, and high cholesterol. Participants take either the probiotic or a placebo daily, and researchers m…

This study compares two ways to replace a narrowed heart valve in people with severe aortic stenosis who are at intermediate risk for surgery. About 1,400 participants will be randomly assigned to get either a less invasive TAVI procedure or open-heart surgery (SAVR). The main go…

This phase 3 trial tests two things at once in 2312 people with coronary artery disease: a new drug-coated stent (Angiolite) versus a standard stent, and a shorter course of blood thinners versus the usual longer course. The goal is to see if the new stent works as well and if sh…

This study tests whether adding culturally tailored heart-health education to medically tailored meal programs helps people with type 2 diabetes and high blood pressure eat better and improve their blood sugar and blood pressure. About 176 adults from low-income New York City nei…

This study was designed to test the safety and tolerability of a new drug called JK07 in people with heart failure and a specific type of high blood pressure in the lungs. It planned to enroll about 20 to 30 adults aged 18 to 85. However, the study was withdrawn before any partic…

This study tests a new eye drop called DE-117B in 345 Chinese adults with open-angle glaucoma or high eye pressure. The goal is to see if it safely lowers eye pressure better than an existing drug. Participants use the drops once daily for at least 4 weeks, with long-term follow-…

This study looks at whether automatically sending home blood pressure readings to doctors and getting automated advice through a patient portal can help people with high blood pressure lower their numbers better than just writing them down. About 1,300 adults with uncontrolled hy…

This study looks at how well new, custom-made and off-the-shelf stent-grafts work for repairing complex aortic aneurysms (bulges in the main artery). About 750 people with aneurysms in the abdomen, chest, or arch will be treated using a less invasive procedure through blood vesse…

This study is following 450 people with long blockages in their leg arteries who are treated with the DETOUR System, a device that creates a bypass inside the artery. The goal is to see how well it works and how safe it is in everyday medical practice. Participants are chosen by …

This study tests whether a nurse-led smoking cessation program with free drugs and follow-up at healthy life centers helps heart patients quit smoking better than just giving them written information. About 221 daily smokers hospitalized for a heart event will be split into two g…

This study tests a community-based program to help Black and Latino adults with diabetes, prediabetes, high blood pressure, or obesity. Participants receive lifestyle coaching, help connecting to health and social services, and digital skills training. The goal is to see if this …

This study tests whether a less invasive procedure called TAVR (replacing the aortic valve through a tube in an artery) is as safe and effective as open-heart surgery for people with severe aortic stenosis who are otherwise healthy enough for surgery. About 2,200 participants wil…

This study tests a mobile health system called mGlide that helps patients with uncontrolled high blood pressure monitor their BP at home and automatically share readings with their healthcare team. The system alerts doctors when BP goes off track, allowing for timely medication a…

This study tests a new stenting technique called double kissing nano-culotte for people with complex blockages in heart arteries. The procedure uses two stents with minimal overlap to keep arteries open. Researchers will track 12 patients for heart attacks, repeat procedures, or …

This Phase 2 trial tests an experimental eye drop called BL1107 against a standard treatment (timolol) in 252 adults with glaucoma or high eye pressure. Participants use the drops twice daily for 28 days. The study measures changes in vision and eye pressure to see if BL1107 is s…

This Phase 3 trial tests whether a daily pill called AZD0780 can safely lower LDL (bad) cholesterol in adults with heart disease or at high risk. About 3,100 participants will receive either AZD0780 or a placebo for 52 weeks, and neither they nor their doctors will know which the…

This study tests a new device called the Navitor TAVI system to replace a stiff, narrowed heart valve without open-heart surgery. It includes 1,500 people with severe aortic stenosis who are at low or intermediate risk for surgery. The goal is to see if the device is safe and eff…

This study tests whether showing people their own coronary CT scans can motivate them to lower their LDL cholesterol and reduce side effects from statins. 273 adults with non-obstructive coronary artery disease will be followed for 12 months. The goal is to see if visual feedback…

This study compares two treatments for complex blockages in the leg's main artery: one avoids stents by using a drug-coated balloon, the other uses a stent. About 120 people with peripheral arterial disease will be randomly assigned to one approach. The goal is to see which keeps…

This study tested a new device called the ACURATE neo2, which replaces a narrowed heart valve without open-heart surgery. About 1,900 people with severe aortic stenosis received either the new device or a standard one. The goal was to see if the new device is safe and works as we…

This early study is testing a new device called the DurAVR™ THV System, which is a replacement heart valve placed through a small tube in the leg (TAVI procedure). The study includes 40 people with severe aortic stenosis or a failed surgical valve. The main goal is to see if the …

This study is testing a less invasive procedure called TAVR to replace the aortic valve in 150 people who have a bicuspid aortic valve (a valve with two flaps instead of three) and severe narrowing. The goal is to see if it is safe and works well for people who are at low risk fo…

This study tests a minimally invasive heart bypass surgery for people with blockages in multiple coronary arteries. Instead of opening the chest fully, surgeons work through a small incision on the left side. The goal is to see if this approach is safe and effective, with fewer c…

This study looks at the best way to stop tocilizumab in people with giant cell arteritis, a type of blood vessel inflammation. About 120 participants will either stop the drug suddenly or taper it slowly over time. The goal is to see which approach leads to fewer relapses and all…

This study tests a device that uses radiofrequency energy to calm overactive kidney nerves, which can drive high blood pressure. About 1,900 adults with uncontrolled hypertension will receive the procedure and be followed for years. The goal is to see if this approach safely and …

This study is testing a less invasive procedure using stent-grafts to treat various types of aortic disease, including aneurysms and dissections. It involves 170 participants who are considered too high-risk for traditional open surgery. The goal is to see if this endovascular ap…

This phase 3 trial tests whether a monthly injection of pelacarsen can reduce major heart problems like heart attacks and strokes in people with high levels of Lp(a), a genetic risk factor. Over 8,000 participants with existing heart disease are being followed for several years. …

This study tests a device that uses ultrasound to burn nerves around the kidney arteries, aiming to lower blood pressure in people with autosomal dominant polycystic kidney disease (ADPKD) whose blood pressure remains high despite medication. 44 participants will be randomly assi…

This study tests whether a bedside device called Quantra can help doctors decide when to give blood transfusions during complex heart surgery. The device measures how well a patient's blood clots in real time. Researchers hope this will reduce the number of blood products (like r…

This study tests a new laser-based device that breaks up calcium deposits in the heart's arteries before placing a stent. About 426 adults with coronary artery disease will receive the treatment. The goal is to see if the device safely improves stent delivery and reduces complica…

This study compares two ways to decide which blocked arteries to stent in heart attack patients who have multiple blockages. One method uses standard X-ray images; the other uses a computer analysis of those images to measure blood flow. About 1,800 patients will be randomly assi…

This study tests an inhaled drug called frespaciguat (MK-5475) in 129 adults who have high blood pressure in their lungs caused by COPD. The main goal is to see if the drug helps people walk farther in 6 minutes after 24 weeks compared to a placebo. Participants take one daily in…

This study looks at whether a procedure called endovascular treatment (EVT) can help people who have had a mild stroke caused by a blocked large artery in the brain. About 300 participants will either receive EVT plus standard medical care or standard care alone. The goal is to s…

This study looks at two treatment options for people who have both a leaky heart valve (ischemic mitral regurgitation) and blocked heart arteries. One option is open-heart surgery to fix the valve and bypass the blockages at the same time. The other is a less invasive procedure t…

This large phase 3 study tests a new cholesterol-lowering injection called inclisiran in over 16,000 people who have already had a heart attack, stroke, or artery surgery. The goal is to see if it safely reduces the risk of future heart attacks, strokes, or the need for emergency…

This phase 3 trial tests a procedure called renal denervation, where a small amount of alcohol is injected around the kidney nerves to calm overactive signals that raise blood pressure. 142 people with uncontrolled hypertension will either get the real procedure or a sham (fake) …

This study tests a smartphone app called MED-AD that sends reminders and tracks medication use for people with heart disease, high blood pressure, or high cholesterol. About 1,000 adults in Oman will be randomly assigned to use the app, receive daily text reminders, or get usual …

This study tested whether injections of cells from donated placentas could improve blood flow and help heal foot ulcers in people with diabetes and blocked leg arteries. The trial planned to enroll about 24 adults with hard-to-heal foot sores. However, the study was withdrawn bef…

This trial tests a nurse-led health program for women aged 45 to 64 in Hong Kong. The program uses a 5-step approach (ask, advice, assess, assist, arrange) to help women manage conditions like high blood pressure, anxiety, and menopause symptoms. Researchers will compare the prog…

This study is testing a new surgical heart valve (Model 400) in over 1,300 people with aortic valve disease. The valve is designed to replace the damaged aortic valve and improve blood flow. Researchers are checking how safe the valve is and how well it works over one year, looki…

This early-stage trial is testing a single biodegradable implant placed in the eye to lower pressure in people with open-angle glaucoma or ocular hypertension. The implant slowly releases medication over time and then dissolves. The study includes 12 adults and focuses on safety,…

This study tests whether the drug eplerenone works better than amlodipine for controlling high blood pressure in Black adults who carry a specific gene variant (LSD1 risk allele). About 300 participants will follow a controlled diet and take escalating doses of one of the two dru…

This study tests a new drug-coated heart stent (VIVO ISAR) against a standard one (XIENCE Skypoint) in 40 people with coronary artery disease. Each patient receives both stents in different blocked arteries, and doctors use a special camera to check healing after one month. The g…

This pilot study tests whether checking blood pressure at home and talking to a pharmacist weekly by phone can help manage uncontrolled hypertension after an emergency department visit. Twenty-four participants will be split into two groups: one receives the home monitoring and t…

This study looks at how the timing of meals and sleep patterns influence blood sugar, heart health, and weight loss in adults with type 2 diabetes, obesity, or high blood pressure. Researchers will provide nutritional guidance and track changes in weight, lab results, and body me…

This Phase 3 trial compares two drugs—methotrexate and tocilizumab—for treating giant cell arteritis, a condition that causes inflammation in large arteries. Both drugs are given alongside a tapering course of prednisone. The goal is to see if methotrexate, a cheaper and easier-t…

This study looks at how safe and effective the Avalus Ultra artificial heart valve is for people with aortic valve disease. About 190 participants will be followed for one year after surgery to check for problems like blood clots or valve failure, and to see how well the valve wo…

This Phase 3 trial is testing an oral drug called MK-0616 (enlicitide decanoate) in about 14,550 people at high risk for heart problems. The drug aims to lower cholesterol and reduce the chance of major events like heart attacks, strokes, and emergency artery procedures. Particip…

This study tests a newer drug-coated stent (Resolute Onyx) against an older one (Resolute Integrity) in 550 people with blocked heart arteries in China. The goal is to see if the new stent works better at keeping arteries open after angioplasty. Participants receive one of the tw…

This study tests a device that uses ultrasound to disrupt overactive nerves in the kidneys, which can drive high blood pressure. About 282 adults with hypertension will either get the real procedure or a sham (fake) procedure. The goal is to see if this treatment safely lowers bl…

This study tests whether a Mediterranean diet combined with intermittent fasting can reduce liver scarring (fibrosis) better than the weight-loss medication naltrexone/bupropion. About 70 adults with overweight or obesity and heart or metabolic risks (like type 2 diabetes or high…

This study looks at the long-term safety of relacorilant, a drug for people with Cushing syndrome. It includes 125 adults who previously completed a relacorilant study and may benefit from continued treatment. Researchers will track side effects over time to see if the drug is sa…

This study is testing a new device called the ChEVAS System for people with complex abdominal aortic aneurysms (bulges in the main blood vessel near the kidneys). The device is placed inside the blood vessel using a catheter, avoiding open surgery. Only 13 people are enrolled, an…

This study tests a special stent coated with a drug called zotarolimus to treat people with blocked heart arteries. The stent is placed during a procedure to open the artery and slowly releases medication to prevent re-blockage. About 591 participants in China are being followed …

This study is testing a device that uses radiofrequency energy to calm overactive kidney nerves, which can drive high blood pressure. It includes 1,000 people whose blood pressure stays high despite taking three or more medications, or who can't tolerate those drugs. Researchers …

This study tests whether advanced CT imaging can help doctors plan better coronary bypass surgery for 200 people with heart disease. Participants get a CT scan before and after surgery to measure blood flow changes. The goal is to improve surgical decisions and reduce chest pain,…

This study aimed to compare a new type of heart stent that slowly dissolves over time (MeRes100) with standard permanent metal stents in people with coronary artery disease. The trial was planned to include about 2,000 participants worldwide, but it was withdrawn before enrolling…

This study tests whether a very low blood pressure target (below 120 mmHg) can prevent major heart problems in people who have had a stroke or mini-stroke. About 4,300 participants are randomly assigned to either intensive or standard blood pressure control and followed for about…

This study tests a device called Paradise™ that uses ultrasound to calm overactive nerves in the kidneys, which can drive high blood pressure. Researchers will compare the device to a sham (fake) procedure in 154 adults with hypertension who are already taking two blood pressure …

This study is testing a newer version of a heart valve device, called the SAPIEN 3 Ultra, in 200 people with severe aortic stenosis (a narrowed heart valve). The valve is implanted through a tube in an artery, avoiding open-heart surgery. Researchers are checking how well the val…

This study tests whether giving people free boxes of fruits and vegetables along with nutrition education can improve health in three Mississippi counties with high rates of diabetes, obesity, and poverty. About 300 adults with high blood sugar or obesity will receive produce and…

This study tests a temporary heart pump called Impella ECP in 100 adults undergoing high-risk angioplasty. The pump helps maintain blood flow during the procedure. Researchers are checking if the device is safe and works as intended, with follow-up for 30 days after the procedure…

This study is testing a small mechanical heart valve (15mm) in 20 children who need their aortic valve replaced due to disease or damage. The valve is designed to last and is monitored for safety and function over 5 years. Children will need lifelong blood-thinning medication to …

This study compares taking two blood thinners for just 1 month versus the standard 12 months after getting a heart stent. It involves over 3,700 patients with acute coronary syndrome. The goal is to see if the shorter regimen reduces bleeding risks without increasing heart proble…

This study compares two ways to help stroke survivors control their blood pressure using telehealth. About 86 participants will receive either enhanced remote monitoring or standard care. The goal is to see which approach better helps people reach a safe blood pressure target and…

This study tests whether using intravascular ultrasound (IVUS) to guide a specific stenting technique (DK crush) leads to fewer heart problems than standard angiography guidance. About 556 adults with complex coronary bifurcation lesions will be randomly assigned to one of the tw…

This study tests a new heart valve called the NAVITOR, placed using a thin tube (catheter) without open-heart surgery. It includes 434 people with severe aortic stenosis who are at intermediate or low risk for surgery. The main goals are to check for leaks around the valve at 30 …

This study looks at whether eating oats for 6 weeks can improve cholesterol, blood pressure, and gut health in people who are overweight or have high cholesterol. Participants will follow a low-gluten diet rich in either oats or rice. Researchers will measure blood fats, inflamma…

This Phase 3 trial is testing whether a monthly injection of ziltivekimab can reduce the risk of heart attacks and strokes in 6,200 people who already have heart disease, chronic kidney disease, and signs of inflammation. Participants receive either the drug or a placebo for up t…

This study tests a daily pill (obicetrapib plus ezetimibe) to see if it can reduce fatty plaque buildup in the arteries of 300 adults with heart disease. Participants must already be on cholesterol-lowering therapy but still have high LDL cholesterol and measurable plaque. The tr…

This study tests whether adding an external support device to vein grafts during heart bypass surgery helps keep them open over time. Researchers will compare patients who receive the support with those who don't, tracking graft function and symptoms like chest pain. The goal is …

This early study is testing a new balloon-expandable heart valve device (TAVI) in 8 people with severe aortic stenosis who are at increased surgical risk. The goal is to see if the device can be safely delivered and perform as intended. Because this is a first-in-human study with…

This study looks at the long-term safety of an inhaled drug called GB002 for people with pulmonary arterial hypertension (PAH), a serious lung condition. It includes 74 patients who already completed a previous GB002 study. Researchers will track side effects and measure how far …

This study tests a new drug, Oxacom®, in 200 adults with pulmonary arterial hypertension (PAH), a serious lung condition that makes it hard to breathe. The drug is given in different doses to see if it can lower pressure in the lung's blood vessels better than a placebo. The goal…

This study follows 116 people who received an experimental gene-editing therapy for heart disease or high cholesterol. Researchers will monitor them for 15 years to track any side effects and how well the treatment controls cholesterol levels. The goal is to understand the long-t…

This study tests whether teaching kidney transplant recipients to eat a whole-food plant-based diet can improve their blood pressure, blood sugar, and weight, and reduce hospital visits and infections. About 49 adults who had a kidney transplant in the past 2–12 months and have h…

This study compares using a manual clot-removal catheter (Export) before standard balloon angioplasty versus angioplasty alone in 300 heart attack patients with completely blocked arteries. The goal is to see if removing the clot first improves blood flow and reduces in-hospital …

This study tests a new app called COACH that helps patients and their doctors work together to control high blood pressure. The app connects home blood pressure readings to the patient's medical record and sends reminders based on behavioral science. About 550 adults with high bl…

This study tests a device called the Cleaner Pro Thrombectomy System, which is threaded through a blood vessel to suction out clots in the lungs of people with acute pulmonary embolism. The trial aims to see if the device safely reduces heart strain and avoids major complications…

This study tests two methods to increase referrals to a centralized pharmacy service for managing statin therapy in patients with or at high risk for heart disease. One method sends reminders to doctors during office visits, and the other sends electronic messages outside of visi…

This study tests a video-based healthy lifestyle program for adults aged 50 to 74 who are overweight and have conditions like prediabetes, type 2 diabetes, or high blood pressure. Participants use a tablet, scale, and activity tracker at home, and some get extra support from a co…

This was a very early (Phase 1) study that planned to give a mixture of cold saline, minocycline, and magnesium directly into the brain's arteries right after a stroke procedure to reopen blocked vessels. The goal was to see if this cocktail could safely protect brain tissue and …

This study tests a new device called the MicroStent, a small mesh tube placed in leg arteries below the knee to keep them open. It involves 177 adults with severe peripheral artery disease who have pain at rest or non-healing sores. Half get the stent plus standard balloon treatm…

This study compares three common heart medications (nicorandil, diltiazem, and isosorbide mononitrate) to see which best prevents the narrowing or failure of radial artery grafts used in coronary artery bypass surgery. About 150 adults who recently had bypass surgery will take on…

This study is a patient registry that follows 300 adults with pulmonary arterial hypertension (PAH) who are starting or recently started Orenitram. Researchers will track how well patients tolerate the drug and how it affects their daily function and symptoms over 78 weeks. The g…

This study tests a special balloon designed to open up hardened leg arteries in people with peripheral artery disease. About 58 participants with moderate to severe calcium buildup will receive the balloon treatment. Researchers will check if the balloon successfully widens the a…

This study looks at whether game-like features and social rewards can help overweight veterans with high blood pressure become more physically active. About 725 veterans will take part in a 9-month program where they either compete or cooperate to increase their daily steps. The …

This study tests whether having more frequent checkups with an obstetric provider or a study nurse during the first year after childbirth can help women with high blood pressure or diabetes manage their health better. One hundred women with Medicaid insurance who had these condit…

This study tests a new inhaled drug called L606 (liposomal treprostinil) in 28 adults with pulmonary arterial hypertension or PH-ILD. The goal is to see if it is safe and tolerable when taken twice daily, both short-term and over a year. Participants either switch from another in…

This study looked at 800 adults who had a stroke from a large blood clot in the brain. It compared a new device called the NeVa Stent Retriever to standard devices used to remove the clot. The goal was to see if the new device could restore blood flow better and with fewer side e…

This large study is testing whether a lower blood pressure target can reduce major heart problems like heart attacks, strokes, and heart failure in people with type 2 diabetes. About 9,500 participants with high blood pressure and high cardiovascular risk are being randomly assig…

This study tests whether evogliptin, a drug originally for diabetes, can slow calcium buildup in the aortic valve of people with mild-to-moderate aortic stenosis. About 580 adults will take either the drug or a placebo daily for two years. The main goal is to see if the drug redu…

This study compares two types of TAVI valves (Edwards and CoreValve Evolut) in 102 people with small, failing surgical aortic valves. The goal is to see which valve leads to fewer problems like high pressure or leakage after the procedure. Results could guide doctors in choosing …

This study compares two ways to replace a narrowed heart valve in elderly patients (65+) who have a small valve opening. One method is less invasive (TAVR, through a tube in an artery), the other is open-heart surgery. The goal is to see which approach gives better blood flow and…

This early study tests a new freezing treatment for people who recently had a heart attack or unstable chest pain. The treatment uses a special balloon to freeze high-risk plaque in the heart's arteries that could rupture and cause another heart attack. The goal is to stabilize t…

This study tests whether giving stroke patients extra tests—like checking for hidden heart problems, artery stiffness, and leg circulation—can lower their chance of having another stroke or heart attack. About 600 people in Stockholm will get this expanded check-up and a personal…

This study follows 255 Chinese patients who received the INSPIRIS RESILIA aortic valve to see how safe and well it works over several years. Researchers track problems like valve failure, blood clots, bleeding, and the need for another surgery. The goal is to confirm the valve's …

This study looks at whether opening a completely blocked heart artery with a procedure called PCI, on top of taking standard heart medications, helps people live longer and feel better compared to medications alone. About 2000 adults with stable heart disease and symptoms like ch…

This study tests a six-month mobile app-based cardiac rehabilitation program for people with coronary heart disease. The goal is to see if using the app at home can improve quality of life, self-care, medication adherence, and mental health. About 126 adults who own a smartphone …

This study tests if a smartphone app called OptiZ can help people with high blood pressure get better control of their condition. Participants use the app to track their blood pressure, medication, and side effects, and share reports with their doctor for personalized dose adjust…

This study tests whether a drug called Angiotensin II can help control blood pressure during liver transplant surgery, reducing the need for other strong blood pressure medicines. It involves 50 adults with severe liver disease who are receiving a liver from a deceased donor. The…

This phase 3 trial tests an inhaled drug called seralutinib for people with pulmonary hypertension (high blood pressure in the lungs) caused by interstitial lung disease (lung scarring). About 480 adults will receive either seralutinib or a placebo for 24 weeks, followed by a lon…

This study looks at whether treating patients at home for conditions like infections, heart failure, diabetes, and COPD can lead to better health outcomes and satisfaction compared to traditional hospital stays. Nearly 10,000 adults will receive hospital-level care at home, inclu…

This study offers voluntary screening for newborns in North Carolina to detect a wide range of rare health conditions early. Using a small blood sample already collected at birth, the program tests for dozens of disorders, including spinal muscular atrophy, cystic fibrosis, and m…

This study checks if a Withings smart scale can accurately spot signs of high blood pressure by looking at body measurements like weight and heart rate. Researchers compared the scale's results to a standard blood pressure cuff in 2,500 adults. The goal is to see if the scale wor…

This study looks at whether a new computer program called IMPULSE can better detect pulmonary hypertension (high blood pressure in the lungs) using standard heart ultrasound. About 200 adults with unexplained breathlessness or risk factors will be checked. The goal is to see if t…

This study looks at whether a detailed full-body scan called FDG PET/CT can find hidden cancers in people aged 50 and older who have had an unexplained blood clot. About 1,276 participants will get either the scan or standard cancer checks. The goal is to see if the scan catches …

This study tests a new, gentle device called Boppli that continuously measures blood pressure in newborn babies in the NICU. Researchers will compare it to the standard blood pressure cuff to see if it works better at finding high blood pressure. The study includes 30 infants at …

This study is developing an artificial intelligence tool that can detect hidden plaque in arteries by analyzing photos of the retina (the back of the eye). About 884 adults without known heart disease will have eye photos taken and compared with ultrasound scans of their neck and…

This study looks at whether certain blood markers can identify people without significant coronary artery disease, avoiding the need for more invasive tests. Researchers will enroll 1000 adults referred for a CT scan of the heart. The goal is to see if these biomarkers can accura…

This study tests a new urine test called CercaTest™ Red to predict preeclampsia in pregnant women who show signs of the condition. Preeclampsia is a serious complication involving high blood pressure and organ damage. The test is designed to be used at the point of care, giving q…

This study compares a new AI-based method of analyzing CT scans of the heart to standard care for people with symptoms that might be coronary artery disease. The goal is to see if the AI approach helps doctors diagnose the condition more accurately, control risk factors like chol…

This study looks at people with Long COVID who have new chest pain but no blocked arteries. It tests whether a special heart function test can guide treatment to improve symptoms and quality of life. 108 participants will be randomly assigned to either treatment guided by the tes…

This study looks at CT scans of the heart from 22,000 people who had chest pain. Researchers want to see if certain features of plaque (fatty deposits) in the heart arteries can help predict who will later have a heart attack, stroke, or die from heart disease. The goal is to imp…

This study is testing whether a special home blood pressure monitor that can detect atrial fibrillation (AFib) helps diagnose the condition faster in older adults with high blood pressure. About 1,900 participants aged 60 and older will take daily blood pressure readings and answ…

This study is developing an artificial intelligence system to analyze CT scans of the heart. The goal is to automatically detect and measure dangerous plaque that can cause heart attacks. Researchers will compare the AI's findings with detailed imaging tests and track patient out…

This study looks at two new methods to tell apart blockages in large versus tiny heart arteries. About 68 adults with known or suspected coronary artery disease will get a PET scan and a heart catheterization. Researchers will compare the new measurements with standard tests to s…

This pilot study is testing whether a special ultrasound scope (EBUS) can diagnose acute pulmonary embolism (a blood clot in the lung) in critically ill patients in the ICU. These patients often cannot undergo standard CT scans because they are too unstable or have kidney problem…

This large UK study (EVAREST) aims to improve how doctors interpret stress echocardiograms for diagnosing coronary artery disease. Researchers will collect blood samples and analyze echocardiogram images from up to 23,000 patients to find new biomarkers that make diagnosis more a…

This study aimed to see if a handheld device called CPMX3 could safely estimate brain pressure in children by measuring pressure in a forehead vein. It planned to compare these readings with standard invasive measurements in children aged 8 to 21 who already had brain pressure mo…

This study tests a new PET heart scan that uses 100 times less radiation than current methods. Researchers will scan 200 adults with known or suspected heart artery disease to see if the ultra-low dose still produces clear images. The goal is to make heart imaging safer while kee…

This study enrolls 800 patients having heart attacks to test an artificial intelligence model that reads standard 12-lead ECGs. The AI aims to detect which artery is blocked and how severely blood flow is reduced, at the moment of a heart catheterization. If accurate, this could …

This study looks at whether helping communities switch to cleaner cookstoves can lower indoor air pollution and prevent high blood pressure. About 1,280 households in Nigeria will take part. Some families get extra support to use the new stoves, while others just receive informat…

This study tests whether a music-inspired community campaign, called Music4Health, can help lower blood pressure and improve stroke awareness among 1,412 youth (ages 14-24) and their caregivers (ages 40+) in Nigeria. Participants will take part in listening sessions and activitie…

This study will test a telehealth group prenatal care program called Centering HER in 72 low-income, predominantly Black pregnant women in Kansas who are at moderate or high risk for preeclampsia. Participants will receive routine care plus seven doula-led virtual group sessions,…

This study tests whether a culturally tailored, skills-based program delivered by community health workers can help Latinx and Vietnamese families in Santa Ana, CA, improve their heart health and prevent high blood pressure. About 483 participants will receive either the special …

This study tests whether using a special heart CT scan to guide intensive treatment can reduce major heart problems like heart attacks and strokes compared to standard care. About 15,000 high-risk adults aged 40-75 in rural China will take part. The goal is to see if this persona…

This large Phase 3 study tests whether inclisiran, a twice-yearly injection, can prevent major heart problems like heart attacks, strokes, and heart-related death in people at high risk who have not yet had such an event. Over 14,000 participants are receiving either inclisiran o…

This study tests whether using a smartphone app and a home blood pressure monitor can help prevent heart disease in women who had high blood pressure during pregnancy. 120 women who gave birth at Northwestern Memorial Hospital will use these digital tools for 12 months after deli…

This study tests a community-based program called Thriving Hearts across ten North Carolina counties. Pregnant individuals at risk for hypertensive disorders receive a care kit with a home blood pressure monitor and stress management tools, plus extra support from healthcare prov…

This study tests whether providing fresh meals, health coaching, and education to high-risk pregnant women can reduce the chance of developing gestational diabetes, high blood pressure, or preeclampsia. 69 women in Milwaukee are randomly assigned to either receive the program or …

This study tests a program called Tu'Washindi, designed by and for young women in Kenya. It combines support clubs and community sessions to help girls ages 15-24 reduce intimate partner violence and consistently use HIV prevention pills (PrEP). About 1,562 participants will be f…

This study tests whether a non-invasive electrical stimulation device placed on the skin over the spine can help veterans with spinal cord injury improve blood pressure, exercise capacity, and body temperature regulation. Twenty veterans with injuries between the neck and upper b…

This study tests a new exercise program for people with coronary artery disease who have had heart surgery or a stent. The program combines high-intensity interval training with Nordic walking (walking with poles). Researchers want to see if it is safe, enjoyable, and better at i…

This study tests whether a smartphone-based stress management program can help Black men with hypertension lower their blood pressure and feel less stressed. About 135 participants will either use a culturally tailored app (m-CBSMi) or take a standard online stress course. Resear…

This study tests whether adding two ultrasound-guided nerve blocks to standard pain relief can lower opioid use and pain after coronary artery bypass grafting. 88 adults having elective bypass surgery will be randomly assigned to receive either the nerve blocks plus standard medi…

This study tests whether taking extra salt (5 grams per day in capsules) can improve symptoms and quality of life in older adults (65+) who experience dizziness and falls due to orthostatic hypotension. The trial involves 42 participants and lasts 12 months, focusing on whether s…

This study tests whether an 8-week mindfulness meditation program (MBSR) can reduce anxiety and depression in heart patients who have completed cardiac rehab. About 74 participants will either take the meditation course or continue with standard rehab. Researchers will measure ch…

This study tests whether applying shockwave therapy to the calf muscles can improve blood flow and reduce pain in people with peripheral artery disease. About 138 adults with stable leg pain when walking will receive the treatment. The goal is to see if it helps them walk longer …

This study looks at whether a program that combines physical activity with support from a peer is acceptable and practical for women living with both HIV and high blood pressure. About 50 women aged 40 and older will take part. The goal is to see if women stick with the program a…

This study looks at whether progressive muscle relaxation and finger grip exercises can lower stress, anxiety, and fatigue while improving sleep in pregnant women with preeclampsia. About 90 women will be split into three groups: one doing relaxation exercises, one doing finger g…

This study tests whether using a far red light device on the legs for 10 minutes twice a day can improve walking distance in people with peripheral artery disease (PAD). The trial involves 32 adults aged 50 and older with PAD. Participants use the light at home for four months, a…

This study tests whether wearing inflatable leg cuffs (intermittent pneumatic compression) for six months can improve walking distance in people with peripheral artery disease (PAD). Some participants also combine the cuffs with walking exercise. The goal is to see if the cuffs h…

This study tests whether allopurinol, a common gout medication, can improve heart function in African American veterans with resistant hypertension. Participants take allopurinol for 8 weeks, and researchers measure changes in heart function, exercise ability, and quality of life…

This study tests whether a virtual reality (VR) wellness program can help Black women with high blood pressure reduce stress and improve heart health. Sixty Black women in South Florida will either use a five-week VR program or receive standard educational materials. Researchers …

This trial tests a 6-week program called Ready for Recovery that helps people prepare for aortic aneurysm surgery. The program includes education, healthy habits, stress reduction, and social support. Ten adults having elective surgery will participate to see if the program is fe…

This study tests a nurse-led education program designed to help women in cardiac rehab address sexual concerns after a heart event. Sixty-six women will be randomly assigned to either the program or usual care. The goal is to see if the program improves sexual function, mood, and…

This study compares two types of heart bypass surgery for people with blocked arteries: a minimally invasive approach using small incisions between the ribs versus the traditional method that opens the breastbone. Researchers want to see if the less invasive surgery leads to bett…

This study tests whether 10 weeks of supervised exercise training can improve heart function, oxygen use, and quality of life in people with heart failure and pulmonary hypertension. Forty participants will do three sessions per week at a cardiac rehab clinic. The goal is to see …

This study tests whether exercise delivered through immersive virtual reality can improve physical performance, muscle strength, fatigue, and quality of life in 32 adults with idiopathic pulmonary arterial hypertension. Participants will do virtual reality exercises and be measur…

This study tests whether whole-body aerobic training (like brisk walking) or isolated leg training (with weights) better improves symptoms and quality of life in people with pulmonary arterial hypertension (PAH). About 45 participants with PAH will be assigned to one of the two e…

This early study tests whether a combination of arginine, tetrahydrobiopterin, and vitamin C can boost nitric oxide levels in the blood and help people with peripheral artery disease walk longer without pain. Ten participants will take the therapy and be monitored for changes in …

This study is testing a device called the Neovasc Reducer in 400 people with chronic stable angina who have not found relief from standard treatments. The device is implanted to improve blood flow and reduce chest pain. Researchers will track symptom improvement and any serious s…

This study tests whether a smartphone-based mindfulness training program can reduce stress and improve cardiovascular health in stressed adults aged 45 and older who are at risk for heart disease. About 106 participants will either use the app for 28 days or continue their usual …

This pilot study tests whether a simple 'Talk Test' can safely and effectively prescribe exercise for heart patients recovering at home after bypass surgery or stent placement. Forty participants will be randomly assigned to get exercise instructions based on either the Talk Test…

This study looks for biological markers in the blood and tissue of adults with Marfan syndrome that could signal when an aortic aneurysm is dangerous enough to require surgery. Researchers will compare three groups of Marfan patients: those without aortic aneurysms, those with st…

This study looks at how different levels of pressure from a breathing machine (called PEEP) affect the heart's pumping ability in 28 adults having heart surgery. Doctors will use special imaging and monitors to measure heart function at four different pressure settings. The goal …

This trial investigates whether measuring high-sensitive troponin, a protein released during heart injury, can predict heart complications in people undergoing surgery to open a narrowed carotid artery. About 527 participants will have their troponin levels checked before and aft…

This study follows 2,000 people in China who received the SYNERGY stent to open blocked heart arteries. Researchers are collecting real-world data on safety and major heart events after the procedure. The goal is to see how well the stent performs in everyday medical practice.

This study follows 250 male endurance athletes who were part of an earlier study to see how their heart arteries have changed over time. Researchers will use CT scans and AI to examine plaque buildup and determine if it is stable and harmless or likely to cause heart attacks. The…

This study collects blood and other samples from people with sickle cell disease and healthy volunteers to help researchers understand how inflammation affects blood vessels. Up to 2,000 adults aged 18 and older will take part. The samples will be used in lab tests to support fut…

This study tests whether combining standard monitoring tools with new light-based sensors can better detect a dangerous narrowing of the aorta in newborns. Infants under one month old with suspected aortic arch obstruction will be monitored using resonance Raman spectroscopy, pul…

This study examines health data from about 800,000 Korean adults to see how often conditions like obesity, type 2 diabetes, heart disease, chronic kidney disease, and fatty liver occur together. Researchers will analyze national survey and insurance records from 2013 to 2023. No …

This study tests whether changing how combination blood pressure pills appear in the electronic health record can encourage doctors to prescribe them more often. Over 12,000 patients will be included, and researchers will track whether a simple label like "(PREFERRED)" makes a di…

This study compares two ways of delivering a health and wellness program to people with chronic conditions like diabetes and high blood pressure. One group gets a kit with a tablet and home monitors for blood pressure and blood sugar; the other gets standard phone calls. The goal…

This study looks at whether personalized digital messages can help 12,000 adults with uncontrolled high blood pressure stick to their treatment plan. The messages are tailored using artificial intelligence to encourage doctor visits, medication adherence, and home blood pressure …

This study follows over 3,400 adults who have had a heart stent procedure to understand how continuity of care, health literacy, and medication adherence influence their long-term health. Researchers will track hospital readmissions, medication use, and patient-reported outcomes …

This study looks at how high blood pressure changes the heart's structure in people who work rotating shifts in the Arctic. Researchers will track 550 workers over a year using heart ultrasounds and blood tests. The goal is to understand why some develop heart failure, not to tes…

This study is building a large gene bank by collecting blood samples and health information from nearly 10,000 people who have had heart catheterization or cardiac CT scans. The goal is to identify genetic and other factors that contribute to coronary artery disease. Participants…

This study observes 60 adults undergoing open pancreatic surgery to see if low blood pressure during the operation is linked to higher lactate levels afterward. Lactate is a marker of how well tissues are getting oxygen. The goal is to find patterns that could help doctors adjust…

This study looks at whether an ultrasound measurement of a large vein near the heart (the inferior vena cava) can predict when a patient's blood pressure will drop dangerously during hip replacement surgery. Researchers will measure this vein's flexibility before cement is used t…

This study aims to improve how doctors test for autonomic failure, a condition where the body's automatic functions like blood pressure control don't work properly. Researchers will use advanced imaging, sweat tests, and skin biopsies in up to 89 adults with Parkinson's disease, …

This study tests a wearable device that continuously measures lactate levels in the fluid just under the skin. Researchers want to see if it matches standard blood tests in patients recovering from heart bypass or valve surgery. If it works, the device could make recovery more co…

This long-running study follows nearly 100,000 French women, mostly teachers, since 1990 to understand what factors influence their risk of cancer, heart disease, diabetes, and other major illnesses. Participants fill out questionnaires every few years about their lifestyle, medi…

This observational study tracks 5,000 people taking common blood thinners (like rivaroxaban or apixaban) or antiplatelet drugs (like aspirin). Researchers regularly measure drug levels in the blood to see how they relate to clots or bleeding events. The goal is to find the best d…

This study aimed to see if a personalized exercise app (Gingko Active) could improve physical function in adults aged 45 and older better than a standard exercise booklet. The trial was withdrawn before any participants enrolled, so no results are available. The app was designed …

This study tests a training program that teaches doctors how to better talk with, listen to, and involve patients in their own care. About 180 doctors and their patients with high blood pressure will take part. The main goal is to see if the training is practical and acceptable, …

This study looks at 90 people who recently had a heart attack and have other artery narrowings that may or may not be dangerous. Researchers will use two types of scans—optical coherence tomography (OCT) and magnetic resonance angiography (MRA)—to see if they can tell which narro…

This study tests a new way to find unstable plaques in the heart arteries of people who come to the emergency room with chest pain but are not having a heart attack. Researchers use a simple calcium scan to group patients by risk, then follow up with special PET scans to see if p…

This study tracks 120 adults with heart disease and at least two other long-term illnesses to see how often dangerous drug interactions happen. Researchers check medications, including over-the-counter and herbal products, and follow participants for a year. The goal is to unders…

This study compares a new X-ray system (Azurion R4.0) to an older version during heart procedures like angiography. The goal is to see if the new system lowers the radiation dose patients receive while still allowing doctors to work effectively. About 824 adults from several coun…

This study is sequencing the genes of 1665 people aged 45 to 65 to learn how genetic changes relate to health, especially heart disease. Participants provide blood samples and undergo heart tests. The goal is to improve methods for interpreting genetic data and understand how res…

This study looks at how blood flow in the feet changes during a 12-week heart and blood vessel rehab program for people with narrowed arteries. Researchers will track 80 adults with conditions like peripheral artery disease or coronary artery disease. The goal is to better unders…

This study looks at how a common glaucoma eye drop (latanoprost with preservatives) changes the natural bacteria living on the eye's surface. Researchers will compare the eye bacteria of 45 newly diagnosed glaucoma patients before and after at least 6 months of treatment. The goa…

This study looks at health records of nearly 150,000 people who had knee replacement surgery to see if real-world data can reproduce the findings of a previous clinical trial (RECORD3). The researchers compare two blood thinners, rivaroxaban and enoxaparin, to see which better pr…

This study aims to create a tool that predicts which patients with inflammatory rheumatic diseases (like rheumatoid arthritis, vasculitis, or polymyalgia rheumatica) will develop serious side effects from long-term steroid use. Researchers will collect routine medical data—such a…

This study is not testing a new treatment. Instead, researchers are checking whether information from healthcare claims (like insurance records) can produce the same results as a famous clinical trial called RECORD1. They are looking at data from over 89,000 people who had hip re…

This study looks at whether telling people they have a high genetic risk for heart disease helps them make healthier choices. About 200 adults without heart disease will be followed for one year. Researchers will compare heart health scores between those who learn their genetic r…

This study collects tissue samples from 1,000 people having heart valve surgery to find genetic causes of calcific aortic valve disease. Researchers will compare normal and diseased tissue to understand why the disease develops. Participants must be at least 20 years old and have…

This study was designed to see if a device called AirGlove, which applies heat, could improve blood flow in the legs of people with peripheral arterial disease (PAD). It planned to include healthy volunteers and people with PAD who experience leg pain when walking. However, the s…

This study reviewed medical records of 1000 people who received a special balloon treatment (drug-coated balloon angioplasty) for blocked heart arteries between 2009 and 2015. Researchers tracked major heart problems like death, heart attacks, or need for repeat procedures for up…

This study looks at why some children and teens feel short of breath or have trouble exercising after their first blood clot in the leg (deep vein thrombosis) or lung (pulmonary embolism). Researchers will measure exercise capacity and breathing using special tests. The goal is t…

This study combines data from over 2,500 people with treated and controlled high blood pressure to understand why some still die from heart attacks, strokes, or kidney failure. Researchers are looking beyond blood pressure numbers to find other factors that might predict these fa…

This study looks at how eating mostly ultra-processed foods (like packaged snacks) compared to less-processed foods (like whole fruits and vegetables) affects blood pressure and other heart health markers. About 79 overweight adults will follow special diets to see the difference…

This study is enrolling 15,000 adults who are already scheduled for a coronary CT angiography (CCTA) scan. Researchers will analyze the scan images along with participants' health outcomes over time. The goal is to see if detailed information from the scans can help doctors more …

This study examines how different hospital treatments—sedation, temperature control, and blood pressure management—after a cardiac arrest impact kidney function. Researchers will follow 3500 adults who were resuscitated from a heart attack outside the hospital. The goal is to und…

This observational study follows about 198 patients in Spain who are already taking inclisiran (Leqvio) for high cholesterol linked to heart disease or a genetic condition. Researchers will check if patients reach their LDL cholesterol goals after 6 and 12 months. The goal is to …

This study looks at whether adding a stress CT scan that checks blood flow to the heart muscle helps doctors decide the best treatment for people with known or suspected heart disease. About 2000 adults will be followed to see if this extra test reduces the need for more tests an…

This study looks at whether using a mobile health app (called Penelope) is a cost-effective way to manage high blood pressure disorders during pregnancy. About 250 pregnant women at risk for conditions like preeclampsia will either use the app or track their health on paper. Rese…

This study looks at whether a new care plan can help more people with pulmonary embolism (a blood clot in the lungs) go home from the emergency room instead of being admitted to the hospital. Researchers are working with 14 hospital ERs in Michigan to track changes in how often l…

This study was designed to use a special PET scan to measure brain inflammation in people with asymptomatic carotid artery disease (narrowing of neck arteries without symptoms). It aimed to compare inflammation levels between those with high-grade and low-grade narrowing. However…

This study is tracking over 1,200 adults in Kazakhstan who have high blood pressure to see how many also have signs of chronic kidney disease (CKD). Researchers will measure things like protein in urine and kidney function. The goal is to understand how often CKD goes undiagnosed…

This study looks at two medicines, alirocumab and inclisiran, that help lower bad cholesterol (LDL-C) in people with heart disease. Researchers will use real-world data from about 124 patients to see which drug reduces cholesterol more over time. The goal is to understand how the…

This study tests a web-based tool called gp-multitool.de that helps general practitioners follow guidelines for older patients with multiple chronic conditions. About 659 patients from GP practices in Germany are taking part. The tool lets patients fill out questionnaires online …

This study aims to help adults aged 40 and older in Upper Manhattan get better eye care. It will offer free eye screenings at local health centers and senior centers, and provide support like scheduling appointments and transportation. The goal is to see if this extra help leads …

This study looks at 320 people with complex coronary artery disease who need a stent. It compares using a special camera (OCT) versus standard X-ray (angiography) to guide the stent placement. The goal is to see which method leads to better blood flow after the procedure.

This study looks at skin cells (fibroblasts) from people with Marfan syndrome and other genetic conditions that cause thoracic aortic aneurysms (a bulging of the main artery in the chest). Researchers want to find out how these cells behave differently and what genes or proteins …

This study follows up with people who took part in the CREST-2 trial to see how well treatments for carotid artery narrowing work over the long term. It includes about 2,480 participants who had either surgery, stenting, or intensive medical management. The main goal is to track …

This study looks at whether low blood pressure during major noncardiac surgery harms organs like the heart and kidneys. Researchers are using a non-invasive brain monitor to see if a personalized blood pressure target can be set. 650 patients at cardiovascular risk are being obse…

This study looks at how serious combat injuries affect the long-term health of U.S. military members. Researchers will measure heart function, sleep quality, and stress-related body signals in 200 injured service members. The goal is to understand links between injury severity, s…

This study looks at whether special imaging features from scans can help predict serious outcomes like amputation or death in people with peripheral artery disease (PAD) after they have had a procedure to open blocked leg arteries. Researchers will analyze 200 patients' scans to …

This study tests whether a remotely delivered resistance training program is practical and helpful for Black women aged 30-64 who are overweight, have prediabetes or diabetes, or have high blood pressure. About 37 women will participate from home using their own devices. The goal…

This study collects data from 1,200 patients undergoing surgery for aortic dissection, a life-threatening tear in the heart's main artery. Researchers will track death rates, strokes, and other complications to identify the safest surgical strategies. The goal is to improve outco…

This study follows 500 people with peripheral artery disease (PAD) who undergo a procedure to open blocked leg arteries. Researchers check blood and heart ultrasound before and after the procedure to find hidden heart injury. The goal is to see if certain markers can predict futu…

This study aimed to see if music therapy and mindfulness meditation could help people who had coronary artery bypass surgery improve their blood pressure, heart rate, anxiety, and depression. It planned to enroll 48 adults who had the surgery and were stable. However, the study w…

This study looks at whether a special MRI scan can detect early scarring in the heart muscle of people with leaky heart valves. The goal is to find a way to predict when the heart might start to fail, so doctors can decide on surgery sooner. About 316 adults with moderate to seve…

This study follows 200 adults with high blood pressure and gum disease to see how gum health affects blood pressure and cholesterol levels over 6 to 12 months. Researchers will measure triglycerides and LDL cholesterol to understand the link. The goal is to learn whether treating…

This study tests whether a swallowable camera capsule, controlled by magnets from outside the body, can safely and effectively examine the stomach and esophagus in 30 people preparing for weight loss surgery. Participants swallow the capsule after fasting, and a surgeon guides it…

This study is looking at whether an artificial intelligence tool can help doctors decide which heart surgery patients might benefit from a drug called ulinastatin. Ulinastatin is used to reduce inflammation after surgery, but it doesn't work for everyone. Researchers will analyze…

This study looks at 45 people having carotid artery surgery to see if special brain scans can predict improvements in thinking and memory. Researchers will use PET/CT scans to measure inflammation in the brain and MRI to examine plaque in the carotid artery. The goal is to find i…

This study tracks over 1,700 heart patients who had hip or knee replacement surgery. Researchers want to see how often bleeding or blood clots happen in the months after surgery. The goal is to find better ways to prevent these complications.

This study is creating a statewide collection of blood samples and medical information from people with various brain blood vessel diseases, such as stroke and dementia. The goal is to build a resource that scientists can use in future research to better understand and potentiall…

This study tests whether a tablet-based decision support system helps frontline health workers in India and Nepal provide better antenatal care. About 1,320 pregnant women will take part. The tool guides workers to check blood pressure, blood sugar, urine protein, and hemoglobin,…

This study uses data from over 30,000 Swedish adults to see if using snus (including newer white nicotine pouches) is linked to heart disease, metabolic problems, and poor mental health, independent of smoking. Researchers will compare current, former, and never-users using advan…

This study looks at how high-protein drinks affect certain blood cells (monocytes and platelets) that may play a role in heart disease. Ten healthy adults will drink either a low-protein, high-protein, or leucine-added meal, and researchers will check their blood for changes in c…

This study follows 2000 people who received the AFX2 system, a device to repair abdominal aortic aneurysms. Researchers will track complications like rupture, need for further procedures, and death over 5 to 10 years. The goal is to see how well the device performs in real-world …

This study looks at whether brothers, sisters, and children of people who have had an abdominal aortic aneurysm are more likely to develop one themselves. Researchers will analyze health records from nearly one million people in Sweden. The goal is to better understand how family…

This study looks at whether a 2-minute step test can accurately measure exercise ability in people with pulmonary hypertension, compared to the standard 6-minute walk test. Researchers will enroll 35 adults with the condition and measure oxygen use, heart rate, and breathlessness…

This study looks at whether two simple, non-invasive tests can predict when a patient's blood pressure will drop dangerously during shoulder surgery performed in the 'beach chair' position (sitting upright). The tests are a finger sensor that measures blood flow and an ultrasound…

This study looks at how a common heart valve procedure called TAVI changes the gut microbiome in older adults with aortic stenosis. Researchers will collect blood and stool samples before and three months after TAVI to measure bacterial byproducts and diversity. The goal is to se…

This study will enroll 210 adults aged 65 and older with early aortic stenosis (a heart valve narrowing) to see if an artificial intelligence tool can better predict how fast the disease worsens. Participants will have standard echocardiograms, and researchers will compare the AI…

This study tests a 10-week educational program called HomeStyles-China, designed to help Chinese American adults improve their diet, increase physical activity, and reduce risk factors for heart disease and diabetes. Researchers will enroll 400 participants and measure changes in…

This study aims to find genetic markers that may increase the risk of a pulmonary embolism (a blood clot in the lung) after hip or knee replacement surgery. Researchers will collect blood samples from 100 adults who have had a clot after such surgery and analyze their DNA. The go…

This study looks at whether giving extra support to community health centers helps them screen patients for non-medical needs like food or housing and refer them to community resources. Twenty health centers will be randomly assigned to get this support or not. The goal is to see…

This study looks at 80 women having breast cancer surgery to see if using a mix of two numbing medicines (levobupivacaine and lidocaine) for a nerve block causes more changes in blood pressure and heart rate than using just one (levobupivacaine alone). The goal is to find which a…

This study looks at how a special heart device (BackBeat CNT) affects nerve activity in 15 people with high blood pressure who already have the device implanted. Researchers measure nerve signals and blood pressure with and without the device turned on. The goal is to understand …

This study is closely watching heart and lung changes in extremely low birth weight babies (under 1000 grams) during their first week of life. Researchers want to understand why some preemies develop low blood pressure and related complications. By using standard and new monitori…

This study looks at whether a pre-surgery test called FFR can predict how well arterial bypass grafts work six months after coronary artery bypass grafting (CABG). About 120 patients with multi-vessel heart disease will have an FFR test during their diagnostic angiogram. Six mont…

This study is a large international registry that will collect data from up to 130,000 people who have had a heart attack or unstable chest pain. Researchers will track treatments, outcomes, and safety to understand what works best in real-world care. No new drugs or devices are …

This study tests whether adding automatic reminders to echocardiogram (heart ultrasound) reports can increase the number of patients with heart valve disease who see a cardiologist within six months. Researchers will randomly assign 300 patients' reports to receive no prompt, a p…

This study follows 50 adults who had surgery for coarctation of the aorta (a narrowed main artery). Researchers want to see if exercise-induced high blood pressure causes hidden damage to the heart, arteries, or kidneys. Participants will do a stress test, heart ultrasound, and b…

This study looks at 60 adults with resistant hypertension—high blood pressure that doesn't improve even with multiple medications. Researchers measure artery stiffness using a simple, non-invasive test to see if it can help identify patients who aren't taking their drugs as presc…

This study will observe 200,000 Chinese adults with heart disease to see how their heart and lung function changes over 5 years. Participants will take a special exercise test to measure their fitness. Researchers hope to find better ways to predict future heart problems like hea…

This study looks at whether a specific type of heart stent (zotarolimus-eluting) can be expanded more than usual to treat tricky blockages. Researchers will use a special camera (OCT) to check the stent's size and safety in 30 adults with coronary artery disease. The goal is to s…

This study was designed to compare a newer pacing method (left bundle branch area pacing) with the standard method (right ventricular pacing) in patients who developed heart block after TAVR valve replacement. The goal was to see which method better preserves heart function and r…

This study looks at 40 people who recently had a heart attack and had one blockage treated. Researchers will use special pressure wires and optical imaging to examine other blockages that were not treated. The goal is to see how many of these leftover blockages are actually dange…

This study looks at whether a special heart scan (CTCA) can help find hidden heart disease in people who come to the hospital with chest pain but are not having a heart attack. About 3,170 adults with slightly elevated troponin levels (a sign of heart stress) will get the scan to…

This study looks at how common kidney injury is in newborns in intensive care and what factors increase the risk. Researchers will review medical records of about 4,000 babies from hospitals around the world. The goal is to better understand short- and long-term kidney health, bu…

This study involves 3,600 people who have had a heart stent placed. Researchers want to see if a special cholesterol test (VAP) can help predict when the artery narrows again. Participants provide a blood sample from routine care, and no extra blood draws are needed. The goal is …

This study looks at how certain blood components and heart imaging patterns might help predict the worsening of aortic stenosis, a common heart valve condition in older adults. Researchers will study 65 people with mild or moderate aortic stenosis and compare them to healthy cont…

This study tests whether a Learning Health System (LHS) can improve care for people with high blood pressure, diabetes, and kidney disease in Thai primary care clinics. The LHS uses electronic health records to help healthcare teams identify patients who need more active manageme…

This study follows 770 people who had aortic aneurysm repair using branched stent grafts. Researchers will check kidney function and other organ health over two years to see how different stent designs affect outcomes. The goal is to learn which approaches work best for preservin…

This study looks at whether a coordinated emergency system, like those used for trauma, can help more severe stroke patients get a clot removal procedure called mechanical thrombectomy. Researchers will compare data from before and after the system is put in place across Alabama.…

This study is a large registry that collects medical data and tissue samples from 30,000 people with heart disease and healthy volunteers. Researchers will analyze this information to better understand risk factors, treatments, and outcomes for various heart conditions. The goal …

This study looks at how arm crank exercise (like pedaling with your arms) changes blood flow in people with peripheral artery disease (PAD) compared to healthy adults. Researchers will measure blood vessel function and oxygen levels in the calf before and after exercise. The goal…

This study follows 2,600 adults with coronary heart disease and depression who received a stent. Researchers track major heart problems like heart attacks or death over one year to find what predicts these events. The goal is to better understand the link between depression and h…

This study looks at how exercise affects gut bacteria and blood pressure in African Americans, who face higher rates of hypertension. Researchers will measure changes in blood pressure and gut microbes in 36 sedentary adults aged 30-50. The goal is to understand if exercise impro…

This study looks at over 1,000 South African children ages 5 to 9 to understand why some develop early signs of high blood pressure and heart problems. Researchers will measure blood pressure, body fat, and fitness, and test blood for early warning markers. The goal is to find wa…

This study reviews past clinical trials to see if people with high blood pressure who get it under control with medication actually live longer or have fewer heart-related deaths. Researchers will analyze data from 100 adults who achieved their blood pressure targets. The goal is…

This study tests a new classroom setup where traditional desks are replaced with standing desks, fitballs, and wall boards to get kids moving more. Researchers will track 500 students in Spain to see if this reduces sitting time and improves thinking, fitness, and well-being. The…

This study was designed to see if a test using acetylcholine could predict whether people with congenital heart disease and high blood pressure in the lungs would develop worsening high blood pressure after surgery to close a heart shunt. The test would have measured how well the…

This study looks at whether a heart valve replacement procedure called TAVI can be safely performed in hospitals that do not have on-site cardiac surgery backup. It involves 657 patients with severe aortic stenosis who are at high risk for surgery. The same experienced doctors pe…

This study is collecting data from 400 people with abdominal aortic aneurysms to improve how doctors predict aneurysm growth. The goal is to create more personalized monitoring plans. Participants will have regular check-ups and imaging tests to track changes over time.

This study looks at how stenting a narrowed aorta (coarctation) changes the heart's workload. Researchers use a special catheter to measure pressure and volume inside the heart before and after stent placement. The goal is to understand if stenting fully improves heart function. …

The ORACLE study is testing a new way to evaluate people with possible angina (chest pain) within one day of their doctor's referral. Participants fill out a digital health questionnaire at home, then have an ECG and a blood test for heart damage markers. The goal is to see if th…

This study tests whether using game-like rewards and personal coaching can encourage older adults to walk more after leaving the hospital. About 350 people aged 50 and older with conditions like high blood pressure or heart failure will wear a Fitbit to track their steps. The goa…

This study looks at whether a computer model can predict when stents placed in the leg arteries might break or fail. Researchers will follow 30 adults who receive a stent for blocked leg arteries. The goal is to see if the model can help doctors choose the best treatment and avoi…

This study tests whether ultrasound of the lungs and a major vein (vena cava) can accurately measure fluid status in women with mild preeclampsia after they receive spinal anesthesia for delivery. Researchers will compare ultrasound findings to traditional methods in 62 participa…

This study is looking for the genetic causes of bicuspid aortic valve disease, a common heart condition where the aortic valve has two flaps instead of three. Researchers will analyze DNA from 11,000 participants, including patients and their relatives, to find gene changes linke…

This study gathers genetic and health information from over 6,400 people with bicuspid aortic valve, a common heart defect. Researchers aim to find the genes responsible for the condition and why some patients later develop serious aortic disease. No treatment is given; the goal …

This study examines whether a common gene variation (CYP2C19) influences the long-term risk of serious heart and blood vessel events, such as heart attacks, strokes, and limb problems, in people with vascular disease. Researchers will analyze genetic and health data from 13,000 p…

This study screened over 16,600 adults aged 45-70 with at least one risk factor (like high blood pressure or smoking) but no known heart disease. Researchers used ultrasound and simple blood and urine tests to find hidden signs of atherosclerosis, pre-diabetes, and kidney disease…

This study follows 200 people who had a heart valve replacement (TAVI) to see how often they experience heart rhythm problems in the weeks after the procedure. Participants wear a portable ECG monitor for up to 4 weeks after leaving the hospital. The goal is to learn how common t…

This study tests whether wearing a portable heart monitor for up to three months before a TAVI procedure can detect silent arrhythmias in people with severe aortic stenosis. The goal is to see if catching these hidden rhythm issues early can lead to treatments that improve outcom…

This study follows 2000 people with dilated cardiomyopathy (a weakened, enlarged heart) over several years to learn how genetics and heart scarring affect the disease. Participants give blood for genetic testing and have heart MRI scans. The goal is to improve diagnosis and pave …

This study planned to compare virtual clinic visits (using video calls on tablets) with in-person visits for people with vascular diseases. Doctors would classify patients as low, moderate, or high risk for treatment after each visit type. The goal was to see if virtual visits co…

This study was designed to measure estrogen and testosterone levels in men with liver cirrhosis who also have low blood pressure, compared to those with cirrhosis but normal blood pressure. The goal was to understand why low blood pressure occurs in cirrhosis. However, the study …

This study planned to use a machine learning algorithm to estimate blood potassium levels from a single-lead ECG in hospitalized patients. It was designed as a retrospective analysis of existing data from a home hospital program. However, the study was withdrawn before enrolling …

This study watches 50 people with chronic lymphocytic leukemia (CLL) who are starting a type of drug called a BTK inhibitor. These drugs can cause high blood pressure and irregular heartbeats. Participants will use a wearable device at home to track their heart rhythm and blood p…

This study compares two methods to detect reduced blood flow to the brain during carotid artery surgery: asking awake patients to move their hand versus using a near-infrared spectroscopy (NIRS) headband. The trial involves 160 people with narrowed carotid arteries. The goal is t…

This study aimed to see if a non-invasive finger cuff monitor could track heart function in people with a pulmonary embolism (a blood clot in the lung). The device measures stroke volume and cardiac output continuously, which might help doctors detect early signs of heart failure…

This study was designed to see if breathing in nitric oxide gas could improve blood flow in the lungs of people with a serious pulmonary embolism (a blood clot in the lung). The plan was to measure heart and lung pressures in 20 patients at UCLA. However, the study was withdrawn …

This study aimed to see if a computer could learn to predict how long a patient would stay in a home hospital program. Researchers planned to use data from past patients to train the computer. However, the study was withdrawn before any patients were enrolled, so no results are a…