Heart attack prevention hope for rare cholesterol disorder
NCT ID NCT06832371
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tracks 73 adults with homozygous familial hypercholesterolemia (HoFH), a rare genetic disorder causing extremely high cholesterol and early heart disease. Researchers will compare major cardiovascular events (like heart attacks and strokes) during the first three years of lomitapide treatment to the three years before starting the drug. The goal is to see if this approved cholesterol-lowering medication reduces serious heart problems.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
lomitapide
What this could lead to
If successful, this study could confirm that lomitapide reduces heart attacks and strokes in people with this rare genetic condition.
What could go wrong
This is an observational study, not a controlled trial, so results may be influenced by other factors. The small size (73 patients) limits how broadly findings can be applied.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for DYSLIPIDEMIA are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Locations
-
A.O.U. Città della Salute e della Scienza di Torino - Ospedale Molinette
Torino, Torino, 10126, Italy
-
ARNAS Garibaldi
Catania, Italy, Italy
-
Arcispedale Sant'Anna - Università degli Studi di Ferrara
Ferrara, Emilia-Romagna, 44124, Italy
-
CHRU Lille - Centre Hospitalier Universitaire de Lille
Lille, France
-
CNR Gabriele Monasterio - Centro di Aferesi, Pisa
Pisa, Tuscany, 56124, Italy
-
Centre Hospitalier Universitaire de Lyon (CHU Lyon)
Lyon, France
-
DIMI - Dipartimento di Medicina Interna, Università di Genova
Genova, GE, 16132, Italy
-
Hammersmith Hospital - Imperial College Healthcare NHS Trust
London, England, W12 0HS, United Kingdom
-
Harefield Hospital - Royal Brompton & Harefield NHS Foundation Trust
Harefield, England, United Kingdom
-
Hôpital La Pitié Salpêtrière - Groupe Hospitalier "La Pitié Salpêtrière - Charles Foix"
Paris, France
-
Hôpital de la Conception - Assistance Publique Hôpitaux de Marseille (AP-HM)
Marseille, France
-
METROPOLITAN HOSPITAL, Piraeus
Piraeus, Greece
-
Manchester University Hospital - NHS Foundation Trust
Manchester, England, United Kingdom
-
Ospedale Bassini - ASST Nord Milano
Milan, Lombardy, 20092, Italy
-
Ospedale Borgo Trento - A.O.U. Integrata Verona
Verona, Veneto, 37126, Italy
-
Ospedale Civile di Baggiovara - A.O.U. di Modena
Modena, Emilia-Romagna, 41124, Italy
-
Ospedale San Luigi Gonzaga
Orbassano, Torino, 10043, Italy
-
Ospedale Sant'Anna e San Sebastiano
Caserta, Campania, 81100, Italy
-
Ospedale regionale generale "F. Miulli"
Bari, Italy
-
Policlinico Federico II di Napoli
Naples, Campania, 80131, Italy
-
Policlinico Paolo Giaccone - Università degli Studi di Palermo
Palermo, Sicily, 90127, Italy
-
Policlinico Sant'Orsola - Università di Bologna
Bologna, Emilia-Romagna, 40138, Italy
-
Policlinico Umberto I - Sapienza Università di Roma
Rome, Lazio, 00161, Italy
-
Policlinico di Catanzaro - A.O.U. Mater Domini
Catanzaro, Calabria, 88100, Italy
-
Policlinico di Padova - A.O.U. di Padova
Padova, Veneto, 35128, Italy
-
Queen Elizabeth Hospital Birmingham (QEII - Birmingham)
Birmingham, England, United Kingdom
-
Radboud University Medical Centre
Nijmegen, Netherlands
-
Rotterdam Erasmus Medical Center
Rotterdam, Netherlands
-
Strasbourg University Hospital (CHU Strasbourg)
Strasbourg, France
-
University General Hospital of Ioannina
Ioannina, Greece