Arterial disorder

This trial investigates whether non-surgical gum treatment can improve early signs of blood vessel dysfunction in people with periodontitis who have no known heart disease. Sixty participants will receive one of two types of deep cleaning procedures. Researchers will measure chan…

This phase 2b trial tests a weekly oral tablet called ecnoglutide (VRB-101) for weight loss in 206 adults with obesity or overweight plus weight-related health problems. Participants receive either the drug or a placebo for several weeks. The main goal is to see how much body wei…

This study tests a device called the Hypotension Prediction Index (HPI) that warns doctors when a patient's blood pressure is about to drop dangerously low after surgery. 210 adults having elective surgery under general anesthesia will be randomly assigned to either standard moni…

This study looks at whether the medication Entresto (sacubitril/valsartan) helps Japanese patients with essential hypertension achieve blood pressure targets recommended by Japanese guidelines. Researchers will analyze electronic medical records from a large database, focusing on…

This trial tests whether a structured support program can help people with coronary artery disease maintain regular exercise after completing cardiac rehabilitation. Participants receive group counseling calls, personal phone check-ins, and introductions to community exercise pro…

This study tests a program where people with slightly high blood pressure use a home monitor and get support from a community health worker. The goal is to see if this helps keep blood pressure from rising to dangerous levels. About 600 adults from 20 health centers are taking pa…

This trial tests whether a short, structured counseling method called BATHE can help people with high blood pressure stick to their treatment plan. Adults with hypertension are randomly assigned to receive either the BATHE interview during clinic visits or standard advice on medi…

This study tested a generic version of the blood pressure drug nifedipine against the brand-name version in 50 adults with mild-to-moderate high blood pressure in Colombia. The goal was to see if the generic pill controls blood pressure just as well after 8 weeks. Participants ha…

This study tests whether a very low blood pressure target (below 120 mmHg) can prevent major heart problems in people who have had a stroke or mini-stroke. About 4,300 participants are randomly assigned to either intensive or standard blood pressure control and followed for about…

This phase 2 trial tests whether short-term consumption of concentrated beetroot juice, which is rich in inorganic nitrate, can improve blood flow to the heart and legs, and enhance walking performance in people with peripheral arterial disease (PAD). PAD causes leg pain during e…

This study compares two treatments for a severe type of stroke caused by a blockage in a major artery at the base of the brain. Some patients will get a clot-busting drug through a vein followed by a procedure to remove the clot, while others will have the clot removal procedure …

This trial tests a device called Tigertriever 13 to treat distal ischemic strokes, where a blood clot blocks a small artery deep in the brain. About 168 patients with disabling symptoms will receive either the device or standard medical care within 24 hours of stroke onset. The g…

This study tested whether a drug called GM-CSF can improve symptoms and blood flow in people with peripheral artery disease (PAD), a condition where plaque narrows leg arteries, causing pain and limiting walking. 151 participants received either GM-CSF or a placebo for two 3-week…

This study tested a special sheath (the Protrieve Sheath) placed in a large vein to catch any blood clots that might break loose during a procedure to remove deep vein clots (DVT). The goal was to prevent those clots from reaching the lungs and causing a pulmonary embolism. The s…

This study tests whether tadalafil, a drug often used for erectile dysfunction, can help people with group 2 pulmonary hypertension (high blood pressure in the lungs). About 48 participants will take tadalafil or a placebo for 12 weeks. Researchers will measure how far they can w…

This trial tests a new device that uses sound waves to break up calcium deposits in the heart's arteries, which can harden and narrow them. The study includes adults with coronary artery calcification who are eligible for a procedure to open blocked arteries. The goal is to see i…

This trial tests a device called the Symphony Thrombectomy System in people with acute pulmonary embolism, a condition where blood clots block arteries in the lungs. The device is designed to restore blood flow by suctioning out or breaking up the clots. The study will check how …

This study tested a drug called pelacarsen in 422 Black/African American and Hispanic patients with high Lp(a) levels and existing heart disease. Lp(a) is a genetic risk factor for heart attacks and strokes. The goal was to see if pelacarsen could safely lower Lp(a) levels over 1…

This trial compares two medications, ephedrine and phenylephrine, used to treat sudden low blood pressure during carotid surgery. The main question is whether one drug better preserves oxygen levels in the brain during the procedure. The study involves adults undergoing planned c…

This trial asks whether one way of setting a breathing machine is better than another for children born with a hole in the heart who are having surgery to close it. The hole lets extra blood flow to the lungs, which can make them stiff and harder to inflate. During surgery, a mac…

This trial is evaluating a new device called the Bifurcated Multilayer Flow Modulator (BMFM) for treating abdominal aortic aneurysms that involve the iliac arteries. The device is designed to be implanted inside the blood vessel to help stabilize the aneurysm and prevent it from …

This trial tests three different laser trabeculoplasty methods—selective, micropulse, and pattern—in people with open-angle glaucoma who are already using eye drops to lower pressure. Each participant receives one 360-degree laser session, and the main goal is to see if the metho…

This study tests a new stenting technique called double kissing nano-culotte for people with complex blockages in heart arteries. The procedure uses two stents with minimal overlap to keep arteries open. Researchers will track 12 patients for heart attacks, repeat procedures, or …

This pilot study tests a new laser device for treating open-angle glaucoma and ocular hypertension. The device uses a laser through the sclera (the white of the eye) to lower eye pressure, avoiding the need for a lens to touch the cornea. Researchers will check how safe the proce…

This study tested a special stent designed to open severely narrowed brain arteries in 194 people with symptomatic intracranial atherosclerosis. The goal was to see if the stent is safe and effective at keeping arteries open for at least 12 months. Researchers measured how often …

This trial tests an automated system that monitors blood pressure and delivers medications to keep it stable during spinal anesthesia for cesarean sections. The system aims to prevent low blood pressure, which can cause side effects for both mother and baby. The study includes wo…

This Phase 3 trial tested a once-daily pill called baxdrostat in 218 adults with resistant hypertension—high blood pressure that stays high despite taking three or more medications. Participants received either baxdrostat or a placebo for 12 weeks. The main goal was to see if bax…

This trial tests an automated system that monitors blood pressure continuously and automatically delivers two medications to prevent low blood pressure during cesarean sections under spinal anesthesia. The system is compared to the standard manual approach of giving bolus doses. …

This study tests whether the drug APX-115 can prevent kidney injury caused by contrast dye used in heart procedures. About 230 adults with kidney disease will receive either the drug or a placebo before and after their procedure. The goal is to see if the drug reduces kidney dama…

This trial tests whether a new device called SynFlow 3.0 can safely support the heart during high-risk angioplasty (a procedure to open blocked coronary arteries) as well as the standard VA-ECMO device. About 222 people with severe coronary artery disease and a weakened heart (ej…

This study tested whether community health workers can help Black postpartum patients who had preeclampsia or other pregnancy complications. 61 participants were split into two groups: one received usual care, the other also got support from a community health worker. The goal wa…

This large study is testing whether a lower blood pressure target can reduce major heart problems like heart attacks, strokes, and heart failure in people with type 2 diabetes. About 9,500 participants with high blood pressure and high cardiovascular risk are being randomly assig…

This clinical trial is testing whether two experimental oral medications, AD-224A and AD-224B, can safely lower blood pressure in people with essential hypertension (high blood pressure with no known cause). About 254 participants will take one of the drugs or a placebo once dail…

This study tested a new device that uses sound waves to break up calcium deposits in leg arteries of people with peripheral artery disease. Thirty-five participants received the treatment to see if it was safe and could open blocked arteries. The goal was to improve blood flow wi…

This trial tests whether specially made cookies containing pumpkin seeds and walnuts can improve cholesterol levels in adults with atherosclerosis. For six weeks, one group eats a daily cookie while the other receives usual care alone. Researchers measure changes in LDL and HDL c…

This trial tests whether a procedure called renal denervation — which uses ultrasound to calm overactive nerves around the kidneys — can lower blood pressure and reduce anxiety in people with uncontrolled hypertension. Sixty adults aged 30 to 70 with high blood pressure and eleva…

This trial investigates whether a 10-week Zumba-based exercise program can help lower blood pressure in adults with hypertension. Participants will either join three 50-minute Zumba sessions per week or maintain their usual lifestyle. Researchers will also measure changes in body…

This phase 2 trial tests whether vericiguat, a drug already used for heart failure, can improve blood vessel function in people with vasospastic angina—a type of chest pain caused by spasms in the heart's small arteries, not by blockages. About 57 adults with frequent angina symp…

This trial investigates whether a single injection of selatogrel can quickly prevent platelets from clumping together in people with stable coronary artery disease. Researchers are also checking how fast the drug works, how long it lasts, and whether injecting it in the thigh or …

This trial tests whether a six-session behavioral program that combines standard hypertension self-management with climate change awareness and heatwave preparedness can improve quality of life, reduce psychological distress, and lower blood pressure in adults with high blood pre…

This trial tests whether empagliflozin, a drug already used for diabetes and heart failure, can prevent the heart muscle from thickening or developing fibrosis in people with moderate aortic stenosis. Participants will receive either empagliflozin or standard care for six months,…

This trial tests whether a single drop of timolol maleate, given just before Nd:YAG laser capsulotomy, can prevent a short-term rise in eye pressure. The study includes adults who developed clouding of the lens capsule months after cataract surgery. Half receive the timolol drop;…

This trial tests whether a special compression device called NewMan can reduce bleeding and bruising after a shoulder artery procedure compared to a standard pressure bandage. The study involves 229 adults with blocked leg arteries who need a catheter inserted through the arm. Do…

This trial tests whether providing health education materials and a home blood pressure monitor can help Somali community members in the Greater Mankato area better identify, manage, and prevent high blood pressure. Participants receive simple tools and guidance on diet, exercise…

This study collects follow-up data from about 300 people who have already received a stent-graft to repair an abdominal aortic aneurysm (AAA). The goal is to assess how safe, effective, and durable the repair is over time. Participants had an AAA larger than 4 cm or one growing r…

This study tests whether a procedure to reopen a major blocked artery in the brain can help people who had a severe stroke 24 to 72 hours earlier. About 224 participants will either get the procedure plus standard care or standard care alone. The goal is to see if the procedure i…

This trial tests whether the gas xenon can reduce heart muscle damage during coronary artery bypass surgery compared to two standard anesthetics: sevoflurane and propofol. About 500 adults with coronary artery disease scheduled for elective bypass surgery will be randomly assigne…

This pilot study tests a new type of stent—a drug-coated, spur-shaped device—as a primary treatment for in-stent restenosis, where a previously placed coronary artery narrows again. The trial enrolls up to 9 adults with this condition to see if the device is safe in the short ter…

This study tests whether teaching people with high blood pressure about the Mediterranean diet can help lower their blood pressure and improve their quality of life. About 70 adults with hypertension will either receive diet education or standard care, and their progress is track…

This study tests whether an artificial intelligence system called optima4BP can improve blood pressure control in people with hypertension. The AI analyzes a patient's medications and recommends the best drug adjustments—adding, removing, replacing, or changing doses. Researchers…

This pilot study explores whether an eight-week mindfulness course or a short guided forest bathing program can lower stress and blood pressure in women over 60 who are already taking medication for hypertension. Sixty women are split into three groups: one learns mindfulness, on…

This study tests whether taking date cider vinegar daily, alone or combined with 5:2 intermittent fasting, can improve cholesterol and other metabolic measures in adults with prediabetes and mild to moderate high cholesterol or blood pressure. Participants are randomly assigned t…

This study is testing a special balloon catheter coated with the drug paclitaxel to treat blocked arteries in the legs, a condition called peripheral artery disease. The balloon is inflated inside the artery to open it up, and the drug helps prevent the artery from narrowing agai…

This phase 3 trial tests whether adding Sacubitril/Allisartan to amlodipine can lower blood pressure more effectively than amlodipine alone in people with essential hypertension. Participants are adults aged 18–75 whose blood pressure remains high despite taking amlodipine. The s…

This study looks at the long-term safety and effectiveness of bimatoprost SR, a tiny implant placed in the eye that slowly releases medication to lower eye pressure. It includes people with open-angle glaucoma or ocular hypertension who have already used bimatoprost SR in earlier…

This trial tests whether a prehabilitation program — including exercise, education, and breathing techniques — helps people recover faster after planned heart surgery. The study enrolls adults scheduled for surgery for coronary artery disease, valve problems, or other heart condi…

This phase 3 trial tests whether adding amlodipine to Sacubitril/Allisartan can lower blood pressure more effectively than Sacubitril/Allisartan alone in people with essential hypertension. Participants whose blood pressure remains high after four weeks on Sacubitril/Allisartan a…

This study tests a new device that uses sound waves (lithotripsy) to break up hard calcium deposits in leg arteries, a condition called peripheral artery disease. About 75 adults with moderate to severe symptoms will receive the treatment. The goal is to see if the device safely …

This study looks at a modified surgical technique for children with primary congenital glaucoma, a condition that causes high eye pressure and can lead to blindness if untreated. The surgery combines two procedures to create a better drainage channel for fluid inside the eye. Res…

This phase 2 trial tests whether a new combination pill, QR12000, can lower blood pressure more effectively than existing medications in people with moderate to severe essential hypertension. Participants are randomly assigned to receive either QR12000, one of its components, or …

This trial tests two techniques for treating severely calcified coronary arteries before placing a stent. One uses a super high-pressure balloon to crack the calcium; the other uses intravascular lithotripsy, which sends shockwaves through the artery wall. The study includes 80 a…

This study investigates whether a 12-week moderate aerobic exercise program can improve brain function, cardiovascular health, and cognition in sedentary adults aged 45-65 with borderline or stage 1 hypertension. Participants are randomly assigned to either aerobic exercise or a …

This trial investigates whether a structured exercise program can improve fitness and lower risk factors for heart disease, stroke, and type 2 diabetes in Latina women who have had breast cancer. Participants are randomly assigned to either an 8-month progressive exercise program…

This trial evaluates a device called the TORUS Stent Graft, a mesh tube placed inside the leg artery to keep it open in people with peripheral artery disease (PAD). The study includes about 188 adults with blockages in the thigh or behind-the-knee arteries. The goal is to see if …

This study tests whether a new generic tablet containing selexipag works the same as the brand-name drug Uptravi. Healthy adults aged 18 to 55 take a single dose of each version under fed conditions, and researchers compare how much drug gets into the bloodstream. The goal is to …

This study tests two strategies in low-income seniors with chronic conditions like heart disease, diabetes, or kidney disease. One group gets free preventive medications (no copayment), and another receives personalized education on medication use and lifestyle. The goal is to se…

This study tests whether a 3-month community program combining nutrition education, cooking classes, and exercise can improve health outcomes for people with Cardiovascular Kidney Metabolic (CKM) syndrome—a cluster of conditions including diabetes, high blood pressure, high chole…

This trial is testing a new stent called Renzan to treat blockages in the leg arteries (superficial femoral or popliteal arteries). The study includes about 135 people with moderate to severe peripheral artery disease. Researchers want to see if the stent is safe and effective at…

This pilot study tests whether the DASH diet, lifestyle advice, or a combination of both can lower blood pressure in adults with prehypertension—a condition where blood pressure is higher than normal but not yet in the high blood pressure range. Researchers randomly assigned 32 p…

This study tested whether using a heart MRI to find scar tissue can help decide which people with mild-to-moderate heart failure should get a defibrillator (ICD) to prevent sudden cardiac death. About 449 adults with a weakened heart pump (ejection fraction 36-50%) and scar tissu…

This study tests whether a 12-week vinyasa (flow) yoga program done at home via Zoom can improve heart health in people with high blood pressure. Thirty adults with elevated blood pressure will be split into two groups: one does yoga three times a week, the other continues their …

This study investigates whether eccentric cycling—where the pedals resist the rider's effort, similar to walking downhill—can improve exercise capacity in people with heart or lung conditions. Unlike normal cycling, eccentric cycling demands less oxygen, which may allow patients …

This study tests whether a simple foot exercise called the soleus pushup can improve cholesterol, blood sugar, and hormone levels in people with thyroid problems, high blood pressure, or diabetes. Participants will perform the exercise, and researchers will measure changes in blo…

This study tests whether infusing cold saline directly into the brain during emergency clot removal can improve recovery after a severe stroke. About 258 adults aged 18 to 80 with a large-vessel blockage in the front part of the brain will be randomly assigned to receive either s…

This trial investigates whether a daily dose of olive leaf extract (atherolive) can help control blood pressure and improve cholesterol levels in adults with hypertension. Participants are randomly assigned to receive either the extract or a placebo for three months. The study ai…

This study investigates whether 12 weeks of moderate aerobic exercise can improve heart health, metabolism, and menopause symptoms in postmenopausal women who have two or more chronic conditions like high blood pressure and high cholesterol. Participants will exercise three times…

This trial compares two ways to insert a catheter into the heart during a heart attack: through the wrist (conventional) or through the hand (distal). The goal is to see which method is faster and causes fewer complications, such as blocking the wrist artery. About 550 heart atta…

This study tests a nurse-led program designed to help elderly patients (age 60+) adopt healthier behaviors after undergoing a heart stent procedure (PCI). The program provides information, motivation, and practical skills through in-person sessions, phone calls, and hands-on trai…

This clinical trial is testing a new medication called HGP2102 for people with essential hypertension, or high blood pressure. The study compares HGP2102 to a control drug to see how well it lowers blood pressure over a full 24-hour period. Participants are adults with high blood…

This study investigates whether a structured, personalized exercise plan—tracked with a smartwatch and supported by regular phone check-ins—can help control blood sugar, blood pressure, and weight gain in pregnant women with gestational diabetes, chronic hypertension, or obesity.…

This study tests whether having a pharmacist call both patients with heart disease and their doctors can increase the use of high-intensity statins—powerful cholesterol-lowering drugs that prevent future heart problems. The trial includes adults aged 18 to 75 with atherosclerotic…

This study tests a device called the Penumbra System with Thunderbolt Aspiration Tubing to remove blood clots in people having a severe stroke caused by a blockage in a large brain artery. The goal is to see if the device can safely and effectively restore blood flow within 8 hou…

This study tests whether a web-based coaching program called CardioFit can help people with coronary artery disease become more physically active. Participants use a secure website to create personalized exercise plans with guidance from an online coach. The trial compares Cardio…

This study tests whether an automated phone system that calls smokers with coronary heart disease after hospital discharge can help them quit. Participants receive calls at several time points over six months, checking on their smoking and offering support. The goal is to see if …

This trial tests a special stent graft system designed to repair a complex type of abdominal aortic aneurysm that involves the arteries to the kidneys and gut. The device is placed inside the aorta using a minimally invasive procedure, aiming to seal the aneurysm while keeping bl…

This trial tests a package of services called TASKPEN, which combines HIV care with screening and treatment for high blood pressure, diabetes, and tobacco use. It involves over 5,700 adults living with HIV in Lusaka, Zambia. The goal is to see if this integrated approach helps mo…

This phase 2 trial investigates whether metformin, a standard diabetes medication, can improve lung blood pressure and exercise ability in people with heart failure with preserved ejection fraction (HFpEF) and pulmonary hypertension. Participants take metformin or a placebo for 1…

This study tested whether a drug-coated balloon can stabilize fatty plaques in heart arteries that are at risk of rupturing and causing a heart attack. Researchers treated 45 patients with a recent heart condition, using a special balloon to deliver medication directly to the pla…

This study tests whether a 10-week program of balance and multicomponent exercises can improve muscle strength, flexibility, balance, and endurance in adults over 50 who have high blood pressure. Participants will do exercises like sit-to-stand, bicep curls, and walking tests. Th…

This study looked at how well a mechanical device works to remove blood clots from the brain during a stroke. Researchers followed 230 adults who had a stroke within the previous 8 hours and received the procedure. The goal was to see if the treatment helps patients recover and r…

This trial tests whether a new 3D-imaging method called vFFR works as well as the standard pressure-wire technique (FFR) to guide treatment for narrowed heart arteries. About 2,200 adults with stable chest pain or a recent non-emergency heart attack will be randomly assigned to o…

This study tested whether sending personalized text messages about lifestyle changes could improve heart health in 700 people who had a stent placed for coronary artery disease. Half received 4 texts per week for 24 weeks, while the other half got standard care. Researchers measu…

This study tests whether motivational interviewing—a supportive, goal-oriented counseling approach—can help people who have had a heart stent adopt and maintain healthier habits. Participants receive one-on-one coaching sessions and reminder texts over three months, while researc…

This study tests whether giving doctors a reminder and providing patients with a one-page handout can help women who had gestational diabetes or high blood pressure during pregnancy get a primary care visit within six months of delivery. The goal is to prevent future diabetes and…

This trial tests a special pacemaker called the BackBeat Moderato that can adjust its pacing to help control high blood pressure. Researchers will turn the device on and off for short periods in 28 people who already have the pacemaker implanted, measuring how their blood pressur…

This study tests a newly designed device to hold arterial pressure monitoring lines in place after coronary artery bypass surgery. The goal is to see if it keeps readings more accurate and stable than standard tape, especially when patients move. Sixty adults undergoing bypass su…

This study tested whether a team of specialists—an endocrinologist, diabetes educator, and dietician—could help people with type 2 diabetes and heart disease control their blood sugar better than standard care. 169 patients were split into two groups: one received usual care from…

This phase 3 study tests whether the drug AGSAVI can lower blood pressure in people with essential hypertension that is not well controlled by the drug AGLS. About 318 adults with high blood pressure will receive either AGSAVI or AGLS, and their sitting blood pressure will be mea…

This study followed 48 people who received the Nellix system, a device that seals abdominal aortic aneurysms from the inside using stents and polymer-filled bags. Researchers tracked how well the device worked right after the procedure and for up to 5 years. The goal was to see i…

This completed study tested whether a 6-week cardiac rehabilitation program (aerobic and resistance exercises) could improve heart disease risk, blood pressure, and arthritis activity in 40 people with both rheumatoid arthritis and high blood pressure. Participants were randomly …

This trial investigates whether bosentan, a drug that blocks endothelin and relaxes blood vessels, can help people who suddenly lose vision from giant cell arteritis (Horton's disease). Standard steroid treatment often fails to restore sight once blindness occurs. The study enrol…

This study investigates whether delivering a clot-dissolving drug directly into the lung arteries via a thin tube (catheter) can improve outcomes for people with a serious type of pulmonary embolism (a blood clot in the lung). Participants have intermediate-high risk clots, meani…

This study tested a device called the PQ Bypass System in 78 people with severe peripheral artery disease (blocked leg arteries). The device is designed to create a bypass inside the artery using small tubes (stent grafts) placed through a needle puncture, avoiding the need for t…

This study tested whether briefly stopping blood flow to the aorta before surgery (called ischemic pre-conditioning) could reduce complications in people undergoing open repair of a thoracoabdominal aortic aneurysm. 65 patients were randomly assigned to receive either the pre-con…

This study tested whether a special balloon procedure, called direct ischemic post-conditioning, can reduce brain injury in people who just had a stroke from a large blocked artery. Sixty patients were randomly assigned to get either standard clot removal alone or clot removal pl…

This study follows about 1,100 Japanese adults with high blood pressure who are prescribed Entresto tablets. Researchers track side effects like low blood pressure, high potassium, and kidney issues over 52 weeks. The goal is to see how safe and effective Entresto is in everyday …

This study tested whether giving low-income adults with high blood pressure free fruits and vegetables for 6 months could help lower their blood pressure. 104 participants from West Dallas, Texas received the produce prescription program. Researchers measured blood pressure chang…

This completed study tested whether eating more fruits and vegetables or taking sodium bicarbonate (baking soda) tablets can slow the progression of chronic kidney disease and reduce heart risks in people with high blood pressure and kidney damage. 108 non-diabetic adults with st…

This study tested whether reducing dietary acid with fruits and vegetables or sodium bicarbonate (baking soda) can slow chronic kidney disease in people with high blood pressure. 153 participants were followed for 5 years to measure kidney function and heart risk markers. The goa…

This study tested whether a natural hormone called DHEA can improve exercise ability in adults with COPD and high blood pressure in the lungs. 51 participants took either a low or high dose of DHEA or a placebo daily for one year. The main goal was to see if DHEA helped them walk…

This study looked at whether giving extra help to clinics (called practice facilitation) improves how well they follow a program to help patients take their blood pressure medicine. The study included 652 Latino adults with uncontrolled high blood pressure who were not taking the…

This study tested whether doing a simple handgrip squeezing exercise three times a week for 24 weeks could lower blood pressure in people with hypertension. 139 adults with controlled high blood pressure took part. The goal was to see if this easy exercise could help manage blood…

This study looked at whether eating a plant-based diet for 12 weeks could lower blood pressure and change gut bacteria in 102 kidney transplant recipients. Participants either followed a plant-based diet or their usual diet. The goal was to see if this diet could help manage hear…

This study tested whether a daily dose of the hormone DHEA can help adults with COPD who also have high blood pressure in their lungs. Sixty participants took either DHEA or a placebo for one year. Researchers measured how far they could walk in six minutes and checked heart and …

This study tested whether a newer stent (Supera) works better than a standard stent for people with blocked arteries in the leg. About 300 patients received one of the two stents. The goal was to see which stent kept the artery open longer and reduced the need for another procedu…

This study looked at 100 people with severe leg artery disease (including some with diabetes) who needed bypass surgery above the knee. Doctors compared using a man-made tube (Dacron or PTFE) versus the patient's own leg vein to reroute blood flow. The goal was to see which metho…

This study tested whether blood thinners (DOACs) work better than aspirin to prevent valve damage and serious heart problems after a less invasive aortic valve replacement (TAVI). 360 patients aged 65-80 were randomly assigned to take either a DOAC or aspirin daily. The main goal…

This study tested whether breathing air with low and then high oxygen before heart bypass surgery could help protect the heart from damage. 120 adults scheduled for bypass surgery took part. The approach is drug-free and aims to reduce complications after surgery.

This study tested a surgical technique called femoral tripod eversion for people with blocked leg arteries. 37 patients were followed for two years to check safety and effectiveness. The procedure aims to clear blockages without using synthetic materials. Early results suggest it…

This early study tested whether injections of cells from donated placentas are safe for people with blocked leg arteries and diabetic foot ulcers. Fifteen adults with diabetes received one of several doses. The main goal was to check for side effects and find the safest dose. Thi…

This study tested a device designed to catch and remove debris that can break loose during transcatheter aortic valve replacement (TAVR), a procedure to replace a narrowed heart valve. The device uses two filters placed in arteries leading to the brain. The trial involved 260 peo…

This phase 2 trial tested whether adding the experimental drug lorundrostat to standard SGLT2 inhibitor therapy can lower blood pressure in adults with chronic kidney disease and albuminuria (protein in urine). Sixty participants received either lorundrostat or a placebo for four…

This study tested whether a half-dose blood thinner (ticagrelor) taken alone after heart stent placement works as well as the standard two-drug therapy in East-Asian patients with chronic coronary syndrome. Sixty participants were randomly assigned to one of three treatment group…

This study looked at whether a progressive resistance training program could help older adults with sarcopenia (age-related muscle loss) control their high blood pressure. 77 sedentary adults aged 60 and older participated. The goal was to see if building muscle strength could be…

This study looked at whether bosentan (Tracleer) can reduce the thickness of lung artery walls in people with a type of high blood pressure in the lungs (pulmonary arterial hypertension, or PAH). Eleven adults with PAH took bosentan for 6 months. Researchers measured artery wall …

This study tested a telehealth program for 30 veterans who misuse alcohol and have high blood pressure or other heart risks. The program included four video therapy sessions to reduce drinking, a coaching call to plan heart-healthy steps, and daily text messages for a month. The …

This study tested a new device called Firesorb, a temporary scaffold that slowly releases medicine to keep heart arteries open and then dissolves over time. Researchers compared it to a standard permanent stent in 430 people with coronary artery disease. The goal was to see if th…

This pilot study tested whether varenicline (Chantix) helps smokers with coronary heart disease quit better than the standard nicotine patch. Fifty motivated smokers who had a heart-related event were randomly assigned to one of the two treatments for 12 weeks. The main goal was …

This study looked at whether bread made from watermelon rind could improve heart health in 120 adults with mild to moderate heart issues. Participants were between 35 and 65 years old and had conditions like high blood pressure, unhealthy cholesterol levels, or pre-diabetes. The …

This study followed 650 low-risk patients with severe aortic valve narrowing who received a less invasive valve replacement called TAVI. Researchers tracked deaths, strokes, and return hospital visits for heart problems. The goal was to see how well TAVI works in everyday practic…

This study looked at whether practicing tai chi—a slow, gentle exercise with deep breathing—could lower blood pressure and improve thinking skills in older adults with high blood pressure. Nineteen participants tried a single session and then a 12-week online tai chi program. Res…

This study looked at 108 people whose heart stents had narrowed again after being placed. Doctors tested three different devices: two types of drug-coated balloons and one new stent. The goal was to see which one works best to keep the artery open and prevent future heart problem…

This study tested a new device called the Vertex Pulmonary Embolectomy System in 10 people with pulmonary embolism (blood clots in the lungs). The device is threaded through a blood vessel to remove clots and relieve strain on the right side of the heart. Researchers measured cha…

This study looked at whether using half the usual dose of heparin during heart surgery (bypass or valve replacement) could reduce bleeding afterward. Heparin is a blood thinner used to prevent clots during surgery, but it can increase bleeding. The study involved 238 adults and c…

This Phase 3 trial tested whether adding cilostazol to rosuvastatin helps people with peripheral artery disease (PAD) more than rosuvastatin alone. PAD narrows leg arteries, causing pain and trouble walking. The study enrolled 260 adults who took either the combo or a placebo for…

This study tested a device called the Nellix system to repair a bulging blood vessel (aneurysm) in the belly without open surgery. 98 people with large or growing aneurysms took part. The goal was to see if the device is safe and works well at keeping the aneurysm from bursting o…

This study tested whether eating yam gruel daily for 12 weeks could improve cholesterol levels in 72 people who had a heart stent placed. Participants either received standard care alone or standard care plus yam gruel as a partial dinner replacement. Researchers measured cholest…

This study looked at how well the AURYON atherectomy device works for people with peripheral artery disease (PAD), where leg arteries become blocked. The device uses a laser to vaporize plaque and restore blood flow. Researchers followed 102 patients to see if the procedure was s…

This study compared two treatments for advanced open-angle glaucoma: a gentle laser (subthreshold diode laser) and a surgical procedure (trabeculotomy). 80 adults with severe glaucoma that was not controlled by maximum medications took part. The goal was to see which treatment be…

This completed Phase 2 trial tested whether a single daily polypill (containing a statin, aspirin, and a blood thinner) could improve medication adherence in 140 patients who had a heart attack and received a stent. The study compared the polypill to usual care with separate pill…

This study tested two different methods of pacing the left side of the heart in people with severe heart failure. The goal was to see if pacing from inside the heart (endocardial) works better than the usual method from outside (epicardial). Only 6 adults took part, and the main …

This study looked at whether a DASH-style diet (modified for diabetes) combined with lower salt intake can lower blood pressure in adults with type 2 diabetes and high blood pressure. 105 participants ate specially prepared meals for 5-week periods. The goal was to find a practic…

This study tested a new way to manage high blood pressure and heart disease risk in people living with HIV in Botswana. Over 4,600 adults on HIV treatment took part. The goal was to see if adding heart health checks and treatment to regular HIV clinic visits helps more people con…

This phase 2 trial tested a drug called orticumab in 77 adults with moderate-to-severe psoriasis who also had cardiometabolic risks (like obesity and high cholesterol). The goal was to see if orticumab could safely reduce skin plaques and inflammation linked to heart disease. Par…

This completed study compared two intravenous blood pressure medications, labetalol and hydralazine, in 132 pregnant women with severe preeclampsia. The goal was to see which drug more effectively lowered blood pressure to safe levels. Results could help doctors in the local sett…

This early study tested a single injection of HM2002, a circular RNA, given directly into the heart muscle during bypass surgery. Only 3 people with heart failure took part. The main goal was to check safety, not to prove it works. The study is complete, but results are not yet a…

This completed Phase 3 trial tested whether a single pill combining ezetimibe, rosuvastatin, and amlodipine can safely lower both cholesterol and blood pressure in 163 Korean adults with hypertension and high cholesterol. Participants took the combination pill or a control for 8 …

This study looked at whether dapagliflozin, a diabetes medication, can improve how the heart uses sugar and blood flow in people with type 2 diabetes and stable coronary artery disease. 25 adults took either the drug or a placebo for 4 weeks. The goal was to see if the drug helps…

This study tested a comprehensive intelligent system (CHESS) to help manage high blood pressure in primary care clinics. Over 1,600 people took part, and the system aimed to lower blood pressure over 12 months. The approach used technology to support doctors and patients in bette…

This study tested a new way to care for people who inject drugs and have hepatitis C. Along with standard hepatitis C treatment, participants were offered HIV prevention medication and buprenorphine for opioid use disorder. The goal was to see if this combined approach could cure…

This study tested a device that uses sound waves to break up calcium buildup in the arteries below the knee in 250 people with peripheral artery disease (PAD). The goal was to safely restore blood flow and avoid serious complications like amputation. Results showed the procedure …

This study tested whether the drug rituximab, given with steroids, works better than steroids alone for people with a rare disease called microscopic polyangiitis that inflames small blood vessels. Only 8 patients took part, and the goal was to see if the combination could preven…

This study tested the drug spironolactone in 15 adults with chronic right-sided heart failure. The goal was to see if it is safe and can improve heart function and reduce stress on the heart. Participants took either the drug or a placebo to compare effects.

This pilot study tested whether colchicine, an anti-inflammatory drug, can slow the buildup of calcium in the aortic valve. 24 adults with mild-to-moderate aortic stenosis were randomly assigned to take colchicine or a placebo for 6 months. The study measured changes in valve cal…

This pilot study tested a hybrid rehabilitation program for people with peripheral arterial disease (PAD), a condition that causes leg pain and limits walking. The program combines a few on-site supervised sessions with a home-based walking plan to make it easier for patients to …

This study tested whether a breathing muscle training device could improve blood flow in the hearts of people with coronary artery disease. Forty participants used the device daily for six weeks. Researchers compared high-intensity versus low-intensity training to see if it incre…

This completed trial tested whether combining a gentle brain stimulation technique called tDCS with intensive rehabilitation can improve hand function in children with hemiplegic cerebral palsy caused by perinatal stroke. 89 children participated, and the study measured changes i…

This study tested two ways to treat blocked leg arteries in 47 people with leg pain when walking. One group had a special device to remove plaque (atherectomy) followed by a drug-coated balloon, while the other had standard balloon angioplasty followed by the same drug-coated bal…

This study tested whether colchicine, a drug used for gout, can reduce inflammation in the arteries of people with diabetes who recently had a heart attack or stroke. Researchers used a special PET scan to measure inflammation in the blood vessels. 115 participants were randomly …

This study looked at whether a 12-week course of glecaprevir/pibrentasivir can safely cure hepatitis C in heart transplant patients who got the virus from infected donors. Fifty adults on the transplant waitlist were enrolled, and those who received a hepatitis C-positive heart w…

This study tested an experimental drug called zilebesiran in 36 Japanese adults with mild to moderate high blood pressure. The goal was to see if it is safe and helps lower blood pressure over 6 months. Participants received either the drug or a placebo, and researchers monitored…

This study tested a device that uses ultrasound to calm overactive nerves in the kidneys, which can drive high blood pressure. Researchers enrolled 44 people with stage 3 chronic kidney disease and uncontrolled hypertension. Half received the real procedure, half a sham, to see i…

This study tested two different blood pressure targets during cesarean section in 390 women with preeclampsia. One group kept blood pressure above 80% of their starting level, the other above 90%. The goal was to see which target led to better newborn outcomes, measured by umbili…

This study tested whether taking two drugs (DWC202206 and DWC202207) together is safe and effective for people with both high blood pressure and high cholesterol. 214 adults aged 19 to 80 took part. The goal was to see if the combination lowered blood pressure and LDL ("bad") cho…

This study tested a new drug called SLx-2101 in 26 adults with moderate to severe high blood pressure. Participants took the pill once daily for up to 12 days to see how well it lowers blood pressure and if it is safe. The goal is to find the right dose for future studies.

This completed Phase 4 trial tested a single pill containing three medicines (telmisartan, amlodipine, and rosuvastatin) in 252 Korean adults with both high blood pressure and high cholesterol. Participants took either the triple pill or a two-drug pill for 8 weeks. The study mea…

This study looked at over 5,500 heart patients in Korea who had a drug-coated stent and took two blood thinners for about a year. After that, they were given either clopidogrel or aspirin alone for up to two more years. The goal was to see which drug better prevents heart attacks…

This study tested whether a structured phone call teaching patients about home blood pressure monitoring would increase the number of people who bring their blood pressure logs to doctor visits. 170 adults with uncontrolled high blood pressure took part. The goal was to see if th…

This study tested two different drug-coated stents (everolimus-eluting vs. sirolimus-eluting) in 1,466 people with narrowed heart arteries. It also compared taking the blood thinner clopidogrel for 6 months versus 12 months after stenting. The goal was to see which stent and whic…

This study tested the drug trametinib in 25 people aged 12 to 60 with complicated arteriovenous malformations (AVMs), which are abnormal blood vessel tangles that can cause pain, bleeding, and heart problems. The goal was to see if the drug could shrink the malformations and impr…

This study tested a drug called olezarsen in 154 adults with high triglycerides (a type of blood fat) and either heart disease or very high triglycerides. Participants received injections of the drug or a placebo for up to 12 months. The main goal was to see if the drug could low…

This study compared two different artificial heart valves (Sapien and Myval) used in a procedure called TAVI to replace a narrowed aortic valve. Over 1,000 patients were randomly assigned to receive one of the two valves. The goal was to see which valve led to fewer major heart p…

This early-stage study tested a single injection of ART101 in 40 healthy adults to see if it is safe and how the body processes it. Participants received either the drug or a placebo. The goal is to gather initial safety data before testing in people with high blood pressure.

This study looked at two ways to treat heart attack patients who have multiple blocked arteries. One group had all blockages fixed in a single procedure, while the other group had the main blockage fixed first and the others in a separate procedure later. The goal was to see if t…

This study tests whether a software tool called AutocathFFR can accurately measure the severity of coronary artery blockages from standard 2D angiogram images, compared to the gold-standard invasive FFR measurement. The software uses machine learning to analyze images taken durin…

This study looked at whether using different blood test cutoffs for men and women can better diagnose heart attacks. Current tests use the same cutoff for both sexes, which may miss heart attacks in women and over-diagnose them in men. Researchers tested new sex-specific cutoffs …

This study tests whether a bedside ultrasound measurement called 'bubble time' can help diagnose pulmonary embolism (a blood clot in the lungs). Researchers will measure bubble time in 250 emergency department patients with suspected embolism and compare it to standard CT scans. …

This study is testing whether measuring a protein called copeptin in the blood, alongside the standard troponin test, can help doctors quickly rule out a heart attack in people arriving at the emergency room with chest pain. Participants with chest pain that started within the la…

This trial tests whether a new device, placed gently in the ear canal, can accurately measure pressure inside the skull without surgery. The device works by detecting tiny changes in inner-ear activity that reflect pressure shifts in the brain. It will be compared to the standard…

This trial tests an AI software called Vital-PICASO that analyzes vital signs like blood pressure, heart rate, and oxygen levels to predict whether a hospital patient will experience hypotension (dangerously low blood pressure) within the next 24 hours. Researchers will review me…

This study tests whether a new device that records chest vibrations from a distance can detect heart and lung diseases. Researchers will compare the vibration patterns of people with known cardiac or pulmonary conditions to those of healthy volunteers. If the technique works, it …

This study tested a new imaging method to detect inflammation in fatty plaques that cause strokes. It involved 3 men who had a recent stroke and were scheduled for surgery to remove a plaque in their neck artery. The goal was to see if a special PET scan tracer could highlight in…

This early study tests a new radioactive dye, F-18 rhodamine 6G, to see if it can produce clearer PET scans of the heart. The dye is injected and then images are taken to measure blood flow in the heart muscle. The trial includes both healthy volunteers and people with stable cor…

This trial checks whether a wrist-worn blood pressure monitor (Model: RIV-B10) can measure blood pressure as accurately as the traditional arm cuff and mercury device. About 158 adults aged 18 and older with wrist sizes between 13 and 21 cm will have their blood pressure taken wi…

This study explores whether a cardiac MRI can safely and effectively gather the same heart pressure and flow measurements normally obtained through right heart catheterization, a more invasive procedure. Researchers will attempt to perform the catheterization inside the MRI machi…

This study looks at whether measuring the optic nerve sheath (the lining around the nerve connecting the eye to the brain) combined with blood tests for angiogenic factors can better diagnose severe pre-eclampsia in pregnant women. Pre-eclampsia is a serious condition that can ha…

This trial evaluates an artificial intelligence algorithm, AutoAS, that analyzes ultrasound images of the heart to detect aortic stenosis — a narrowing of the heart's main valve. Researchers will collect images from adults scheduled for a standard echocardiogram and test how well…

This study looks at whether the ratio of two common blood test results (APTT and fibrinogen) can help diagnose pulmonary embolism, a serious condition where a blood clot blocks an artery in the lung. Researchers will compare this ratio in 1,000 patients who are suspected of havin…

This study compares cardiac MRI to the standard right heart catheterization for monitoring people with pulmonary arterial hypertension (PAH), a condition that strains the heart. Researchers want to see if the non-invasive MRI can reliably detect when a patient's condition is wors…

This study tests whether a new device called VicorderCS can measure blood pressure accurately. The device uses a standard arm cuff and is designed to be faster and more portable than older models. Researchers will compare its readings to those taken with a traditional stethoscope…

This study looked at 105 people to find the best blood test values for diagnosing primary hyperaldosteronism, a condition where the adrenal glands make too much aldosterone hormone, causing high blood pressure. Researchers measured aldosterone and renin levels using advanced lab …

This study tested an AI tool called VeriSee GLC that analyzes color images of the back of the eye to find signs of glaucoma. Researchers looked at 773 adults' existing eye images to see how well the AI could identify people who might have glaucoma, comparing its results to a pane…

This study tests whether a simpler device called pOpmètre can accurately measure arterial stiffness in children aged 4 to 8. Arterial stiffness is an important sign of heart and blood vessel health. The standard device, Sphygmocor, is harder to use in children. If pOpmètre works …

This study compares a new ultra-high-resolution CT scanner (UHR-CT) to the standard invasive coronary angiography for detecting significant blockages in the heart's arteries. It focuses on patients with severe calcium buildup or stents, where regular CT scans often fall short. Th…

This study tested how well a small, portable device (LumiraDx) measures blood clotting (INR) compared to standard lab tests. Researchers collected blood from 420 adults, some taking warfarin and some not, using both a fingerstick and a vein draw. The goal was to see if the device…

This study uses a non-invasive ultrasound called transcranial Doppler (TCD) to measure blood flow in the brains of pregnant women with preeclampsia. Researchers will compare 50 women with preeclampsia to 50 healthy pregnant women to see if TCD can detect early signs of serious co…

This study tested a new rapid D-dimer blood test (LumiraDx) in 679 people with symptoms of deep vein thrombosis or pulmonary embolism. The test uses a small blood sample from a finger prick or vein to quickly measure D-dimer levels, which can help rule out dangerous blood clots. …

This study looked at 15 patients with a rare heart condition called wild-type transthyretin amyloid cardiomyopathy (ATTRwt) who also had signs of aortic stenosis. Researchers used dobutamine stress echocardiography—a test that uses a drug to make the heart pump harder while imagi…

This study looked at whether a ratio of two blood cell types (monocytes and large platelets) can help diagnose acute pulmonary embolism, a serious blood clot in the lungs. Researchers analyzed blood samples from 53 patients who had a CT scan to confirm or rule out the clot. The g…

This study tested whether a high-resolution eye scan called SD-OCT can diagnose glaucoma more accurately than standard methods. Researchers compared 109 people with and without glaucoma using the scan. The goal was to see if this technology could catch the disease earlier, before…

This study tested whether a special ultrasound score (called VEXUS) can predict acute kidney injury in women with severe preeclampsia when they are admitted to the hospital. Researchers examined 70 women using Doppler ultrasound to check blood flow in key veins. The goal was to s…

This study tested a device called ShuntCheck, which uses a mild heat sensor on the skin to see if a brain shunt is flowing properly. Researchers enrolled 12 adults with pseudotumor cerebri who had a shunt placed and were feeling well. The goal was to see if the device could corre…

This study tested whether a computerized stethoscope that uses artificial intelligence (AI) can accurately detect two common heart valve conditions: aortic stenosis and mitral regurgitation. Researchers at Mayo Clinic recorded heart sounds from 400 adults and compared the AI's an…

This study tested a computer program called Heuron CTA that looks at brain CT scans to find large blockages in blood vessels. Researchers compared the software's results to diagnoses made by medical experts using scans from 270 adults. If accurate, this tool could help doctors di…

This study tests a program called Tu'Washindi, designed by and for young women in Kenya. It combines support clubs and community sessions to help girls ages 15-24 reduce intimate partner violence and consistently use HIV prevention pills (PrEP). About 1,562 participants will be f…

This trial tests a program called TEAM, designed to help people at high risk for stroke lower their risk factors. The program involves nurses and peer educator pairs working with patients and their care partners through one-on-one and group sessions. The goal is to see if this ap…

This trial tests whether screening for chronic kidney disease (CKD) in trusted community settings, like churches, can identify people with early kidney damage who don't yet have symptoms. Participants are adults aged 18-70 without known kidney disease who attend community health …

This study tests whether taking a daily vitamin D supplement (4000 IU) can lower the chance of preeclampsia returning in pregnant women who have had it before. Researchers will randomly assign 146 women to receive either vitamin D or a placebo from enrollment until 36 weeks of pr…

This study tests a specially designed set of infection-prevention steps (a 'bundle') for people undergoing coronary artery bypass graft (CABG) surgery. The goal is to see if this bundle reduces surgical wound infections, both superficial and deep. The trial includes 200 participa…

This trial tests whether a 12-week program led by a heart health educator can lower cholesterol and improve heart health in spouses, siblings, and children of people hospitalized with coronary heart disease. Participants work with an educator to create a personal plan for smoking…

This study looked at whether giving low-dose blood pressure medication to people with high-normal blood pressure and other risk factors could prevent them from developing full-blown hypertension, diabetes, or heart problems. 690 participants aged 50-79 were given either telmisart…

This completed study tested a 24-month program that combined face-to-face counseling with digital tools to help families prevent and manage type 2 diabetes and high blood pressure. Over 1,200 adults and their children from Albania, Bulgaria, Greece, and Spain took part. The progr…

This study tested whether making a small opening in the lining around the heart (called a left posterior pericardiotomy) can prevent new atrial fibrillation after coronary artery bypass surgery. 270 adults having bypass surgery were randomly assigned to get this extra cut or not.…

This pilot study tested whether ready-to-eat meals based on the DASH diet could help lower blood pressure and reduce heart disease risk. Twenty adults ate the prepackaged meals daily for 4 weeks while researchers monitored their blood pressure and weight. The goal was to see if a…

This study tested whether colchicine, an anti-inflammatory drug used for gout, can prevent new-onset atrial fibrillation and the need for a permanent pacemaker in people undergoing transcatheter aortic valve replacement (TAVI). About 120 older adults with severe aortic stenosis w…

This study looked at 1168 adults who had a heart catheterization through the wrist. It compared two methods to stop bleeding and prevent a common complication called radial artery occlusion: manual compression (hand pressure) and a pneumatic device that gradually releases pressur…

This large observational study followed over 135,000 Chinese women aged 40-70 to see if eating soy food reduces the risk of heart attacks and fatal heart disease. Researchers tracked participants' soy intake and heart health over time. The study aims to provide clues about diet a…

This study tests whether Emotional Freedom Techniques (EFT) — a therapy that combines tapping on specific body points with focused thoughts — can help people recovering from coronary artery bypass surgery. Researchers will compare 33 patients who receive EFT plus standard care ag…

This study tests whether a walking program that uses FitBit tracking and personalized coaching can help people who recently had a leg amputation due to diabetes or peripheral artery disease become more physically active. Participants will use a FitBit to monitor their steps and r…

This study looked at whether a 10-week supervised aerobic exercise program can help people with pulmonary hypertension (high blood pressure in the lungs) become more active and feel better. About 97 participants, including healthy volunteers and patients, took part. Patients were…

This study looks at whether low-resistance exercise (like light strength training) can safely help people with pulmonary arterial hypertension (PAH) feel better and be less frail. About 20 adults with stable PAH will try the program. Researchers will track safety, how well people…

This study tested two types of nerve blocks (SAP and PECS II) to see if they could reduce pain after coronary artery bypass grafting. 243 adults received one of the blocks or standard care. Researchers measured pain scores, opioid use, and recovery times. The goal was to find a b…

This trial tests whether adding a double nerve block (femoral and sciatic) before general anesthesia can reduce pain and morphine use after femoropopliteal bypass surgery in people with peripheral arterial disease. The block, using levobupivacaine and clonidine, may also widen bl…

This study tests whether giving a nerve block (stellate ganglion block) before coronary artery bypass grafting (CABG) can reduce the chance of developing atrial fibrillation, a common irregular heartbeat after surgery. About 60 adults having CABG will be randomly assigned to rece…

This pilot trial tests a technique called cryoanalgesia, which uses extreme cold to temporarily freeze nerves in the chest during heart surgery. The goal is to block pain signals, potentially reducing the need for opioid painkillers and improving recovery. The study enrolls adult…

This study compared two ways to control pain after minimally invasive heart bypass surgery: a newer erector spinae plane block (ESPB) versus the standard paravertebral block (PVB). 140 patients received one of the two blocks using the numbing drug ropivacaine. The goal was to see…

This trial investigates whether wearing AI-powered active noise-cancelling headphones during rotational atherectomy — a heart procedure that generates loud drilling noise — can reduce patient anxiety and improve heart rate stability. One hundred adults with severe coronary artery…

This study tests whether a medicated skin patch called SP-103 can reduce pain and disability in people with moderate to severe acute lower back pain. Participants wear the patch for 12 hours daily over 28 days. The trial compares the active patch to a placebo patch to see if it t…

This study tested whether a slow, rhythmic breathing technique called resonant breathing can help lower blood pressure, heart rate, and stress in adults with mild hypertension. Fifty adults aged 30-65 with stage I hypertension and no serious health issues practiced this breathing…

This study tested whether listening to music during wound dressing changes can reduce pain in people with severe arteritis (stage 5 or 6). Twenty-five patients were asked to listen to music during their daily wound care. The main goal was to see if pain levels were lower on a 0-1…

This trial tests whether giving a continuous infusion of phenylephrine (a drug that raises blood pressure) can prevent shivering after spinal anesthesia in women having a C-section. About 108 non-laboring women will be randomly assigned to receive either the phenylephrine infusio…

This study tested whether regular phone calls from a nurse after coronary artery bypass surgery could help patients manage symptoms and take better care of themselves at home. 72 patients were split into two groups: one received standard care, and the other got scheduled phone co…

This study tested a device called the Hypotension Prediction Index (HPI) to see if it can reduce low blood pressure during planned C-sections. Low blood pressure after spinal anesthesia can harm both mother and baby. The device alerts doctors before blood pressure drops, so they …

This study tests whether wearing virtual reality glasses during femoral sheath removal — a routine step after a heart catheterization — can lower pain, anxiety, and changes in vital signs. About 60 adults undergoing this procedure will be randomly assigned to either use VR glasse…

This pilot study tested whether adding a 16-week meditation program to standard cardiac rehabilitation helps people with coronary artery disease feel less stressed and anxious. Forty participants were split into two groups: one did meditation plus rehab, the other did rehab alone…

This study tested whether giving the pain medicine sufentanil as a continuous drip during heart surgery helps patients wake up and leave the ICU sooner compared to giving it as single shots. 65 adults having planned heart surgery took part. The goal was to see if the drip method …

This phase 2 trial tests whether daily injections of unacylated ghrelin, a natural hormone, can improve walking ability in people aged 55 and older with peripheral artery disease (PAD). Participants receive either the hormone or a placebo for four months. The study measures chang…

This study tested whether soaking your legs in hot water after a 30-minute walk can lower blood pressure better than exercise or heat alone. Twenty adults with slightly high blood pressure completed four different sessions: walking plus a lukewarm bath, walking plus a hot bath, h…

This study tested two drugs, dexmedetomidine and nitroglycerin, to see which one better reduces bleeding during functional endoscopic sinus surgery (FESS). 66 adults having elective FESS were randomly assigned to receive one of the drugs to lower blood pressure and improve the su…

This study tested whether one-on-one sessions with a trained nurse could help people with resistant hypertension better handle side effects like sexual problems and bladder control issues caused by their blood pressure medications. The goal was to see if this education helps pati…

This study looked at whether Emotional Freedom Technique (EFT), a therapy that involves tapping on specific body points, can reduce pain, pain-related beliefs, and anxiety in people recovering from coronary artery bypass graft (CABG) surgery. Researchers enrolled 66 adults and me…

This study tested two non-drug therapies—graded motor imagery (mental rehearsal) and mirror therapy (using a mirror to trick the brain)—in 44 chronic stroke patients aged 45 to 65. The goal was to see which better reduces muscle spasticity and improves independence. Both therapie…

This study tested whether watching a short video before coronary bypass surgery could reduce confusion (delirium) in the ICU and speed up recovery. 220 adults were randomly assigned to either watch the video or receive standard care. The video explained the surgery, ICU environme…

This study compared two types of nerve blocks—erector spinae plane block and paravertebral block—for pain control after open kidney surgery. 72 adults were randomly assigned to one of the two blocks. Researchers measured pain scores, opioid use, and vital signs during the first 2…

This study tested whether giving vascular surgery patients access to a website with educational videos could reduce their anxiety before the operation. 250 patients were split into two groups: one got the videos, the other did not. Researchers measured anxiety using a simple 0-to…

This pilot study tested a remotely delivered self-management program called TEAM-Red for depressed young African American women who also have risk factors for high blood pressure. 83 women participated in group video sessions over 12 weeks, with researchers tracking changes in de…

This study looked at whether amlodipine, a blood pressure medicine, can help people with stable angina (chest pain) who already have stents but still have narrowed arteries. About 211 participants took amlodipine or no calcium-channel blocker for 9 months. The main goal was to se…

This study looked at whether giving a sedative called dexmedetomidine before placing a breathing tube can prevent sudden rises in blood pressure and heart rate in patients with controlled high blood pressure. 70 adults having planned surgery under general anesthesia took part. Th…

This study tested whether adding mindfulness-based stress reduction (MBSR) to aerobic exercise helps heart patients who recently had a stent procedure. 150 participants were split into two groups: one did only aerobic training, the other added daily mindfulness sessions. Research…

This completed study looked at 670 African American adults to understand how genetics, lifestyle, and social factors like stress and neighborhood affect heart disease risk. Researchers collected blood samples, medical tests, and surveys to find links between ancestry-related DNA …

This completed study looked at how inflammation might connect heart disease and diabetes. Researchers used PET scans and blood tests to measure inflammation in 150 adults, including healthy volunteers. The goal was to better understand these links, not to test a new treatment.

This completed study looked at how much radiation people receive during heart CT scans (CCTA) in everyday hospital practice. Researchers enrolled 66 adults who needed a heart CT and recorded the radiation dose used, along with any dose-saving techniques. The goal was to understan…

This study looked at the genes and lifestyle of over 7,400 people in Nigeria to understand why some develop type 2 diabetes. Researchers compared people with and without diabetes to find genetic differences. The goal is to learn more about diabetes causes in African populations a…

This study measured how common pulmonary hypertension (high blood pressure in the lungs) is in adults with sickle cell anemia. Nearly 1,000 participants had heart ultrasounds and blood tests, then were contacted by phone for up to 3 years to track their health. The goal was to un…

This study looked at how blood vessel stiffness affects organs like the heart, brain, kidneys, and gut in people with Williams Syndrome (WS) or supravalvular aortic stenosis (SVAS). Researchers compared 159 participants (ages 3–85) with these conditions to healthy volunteers over…

This study looks at whether a protein in the blood, called soluble CD95 ligand, plays a role in ANCA-associated vasculitis, a rare group of diseases that cause inflammation of blood vessels. Researchers will collect blood and urine samples from 48 adults with the condition and tr…

This study is observing 66 pregnant women at high risk for preeclampsia to see if changes in their platelets (blood cells involved in clotting) can predict pregnancy complications. Researchers will collect blood samples before and after starting daily low-dose aspirin. The goal i…

This study aims to measure how common glaucoma is among people aged 50 and older in the Bangkoknoi district of Bangkok, Thailand. Researchers will examine about 1,470 volunteers using standard eye tests and advanced imaging to detect signs of glaucoma and gather normal eye measur…

This study looks at how false or misleading health information found online affects the way people with chronic illnesses like diabetes and high blood pressure take their medications and make treatment decisions. Researchers will survey 300 adults who use social media at least on…

This study is testing a chatbot platform called PROMBot that lets people with hypertension report their blood pressure and other health information via text messages. The goal is to see if the chatbot is easy and enjoyable to use, and whether it can help patients stay engaged in …

This study looked at how stretchy the skin and blood vessels are in people with Williams syndrome, a genetic condition that can cause heart problems. Researchers measured skin and pulse speed in 43 participants aged 5 to 70. The goal was to learn how these tissues change over tim…

This study looks at how scar tissue (fibrosis) forms in the heart in conditions like aortic stenosis, heart damage from chemotherapy, and carcinoid syndrome. Researchers will use special PET scans to see active scarring early. About 180 adults will take part to help improve detec…

This study tests whether using the wrist (radial artery) instead of the groin (femoral artery) as a second access point during a minimally invasive heart valve replacement (TAVI) reduces bleeding and other complications. About 542 patients will be randomly assigned to one of the …

This study follows 500 heart bypass patients for 10 years to see if taking two blood thinners (ticagrelor plus aspirin) for one year after surgery reduces the risk of heart attacks, strokes, or death compared to taking just one. Participants will be contacted by phone to report t…

This study collected DNA, tissue, and medical history from 305 people with Williams syndrome or supravalvar aortic stenosis (SVAS), as well as their family members and healthy volunteers. The goal was to create a resource for future research to understand why symptoms vary so muc…

This study compares two methods of placing a breathing tube during general anesthesia without using opioid painkillers. The goal is to see which method—fiberoptic or direct laryngoscopy—causes less change in heart rate and blood pressure. Researchers will study 90 adults aged 18 …

This study is testing whether measuring residual blood volume and excess fluid during hemodialysis can predict the risk of intradialytic hypotension—a sudden drop in blood pressure that can cause dizziness, nausea, or fainting. Researchers will follow 60 adults with chronic kidne…

This study compares two drug combinations (ketamine-lidocaine vs ketamine-fentanyl) used to put patients to sleep before heart bypass surgery. The goal is to see which combination better maintains blood flow to the brain during the procedure. The study includes 40 adults with cor…

This study looks at people with a rare inherited condition that causes extremely high cholesterol and early heart disease. Researchers used special tests to measure artery hardening before it becomes life-threatening. The goal was to gather information to help develop future trea…

This study looked at the safety of the blood thinner rivaroxaban in 1500 Japanese patients with peripheral arterial disease (PAD) who had surgery to improve blood flow in their legs. Researchers used existing health records to track bleeding events and heart-related deaths. No ne…

This study tested how well blood pressure cuffs work on the upper arm, forearm, thigh, and lower leg compared to a standard arterial line. Researchers measured 84 adults during planned surgery. The goal was to see if other sites give accurate readings when the upper arm can't be …

This study tests whether nurses using an AI tool can plan care as well as doctors for common problems like high blood pressure, diabetes, fever, and shortness of breath. About 672 adults in rural and semi-urban India will see both a nurse with AI and a doctor, and their visits wi…

This study tests whether a mild electrical current applied to the scalp (tDCS) can increase blood flow to the brain in people with Moyamoya disease or hardened brain arteries. Researchers will measure changes in blood flow using MRI and check if thinking skills improve. The study…

This study looked at 63 women having laparoscopic hysterectomy to see if two different anesthetics (sevoflurane and desflurane) affect pressure inside the head differently. The researchers measured the optic nerve sheath diameter using ultrasound as a non-invasive way to check br…

This study aims to improve how doctors test for autonomic failure, a condition where the body's automatic functions like blood pressure control don't work properly. Researchers will use advanced imaging, sweat tests, and skin biopsies in up to 89 adults with Parkinson's disease, …

This study looks at how people with coronary artery disease (CAD) respond to arm versus leg exercise. Researchers will measure blood vessel stiffness, muscle oxygen levels, and energy use during both types of exercise. The goal is to better understand exercise limitations in CAD …

This completed Phase 1 study looked at 27 people with and without pulmonary hypertension to learn more about how blood vessel problems contribute to the disease. Researchers used heart catheterization, imaging, and blood tests to find biomarkers and understand disease mechanisms.…

This study looked at data from over 1,600 African Americans aged 30-55 with severe high blood pressure. Researchers examined genetic, behavioral, and social factors to find out why this group is more affected by hypertension. No new participants were enrolled; the goal was to lea…

This study investigates whether fibromuscular dysplasia (FMD), a condition that causes abnormal growth in artery walls, is more common in people who have had a spontaneous coronary artery dissection (SCAD) — a tear in a heart artery that can cause a heart attack, often in young w…

This study looks at whether the 'circle method' — a way to measure the aortic valve — can help doctors choose the right size replacement valve for people with bicuspid aortic valves who are getting a TAVI procedure. Researchers will review past cases to see if patients whose valv…

This study looks at whether substances produced by gut bacteria, called TMAO, can help predict high blood pressure during pregnancy. Researchers will track 200 pregnant women by collecting blood and urine samples throughout their pregnancies. The goal is to find early warning sig…

This trial investigates whether genetic variations in the CES1 gene influence how the body responds to the blood thinners clopidogrel and aspirin. Healthy Amish adults will take clopidogrel for a week, then a single dose of aspirin, with blood tests measuring platelet function be…

This study tests a small, wearable ECG patch that uses artificial intelligence to monitor heart rhythms in patients recovering from cardiac surgery. Participants wear the patch for up to a week after leaving the intensive care unit. The goal is to see if the device can reliably t…

Severe aortic stenosis narrows the heart's aortic valve, and current guidelines recommend waiting until symptoms appear before replacing it. But MRI scans show that up to half of patients already have heart scarring by then, which doesn't fully reverse after surgery. This study w…

This study tested whether taking a synbiotic (a mix of probiotics and prebiotics) for 30 days could improve gut bacteria, weight, and heart health in 47 healthy adults aged 18-60. Participants were randomly assigned to receive the supplement or a placebo. The goal was to gather i…

This trial tests whether an Apple Watch paired with a special app can accurately measure how far people with pulmonary arterial hypertension (PAH) can walk in six minutes — both in the clinic and at home. Researchers want to see if daily home-based walk tests can detect changes i…

This study tracks thousands of heart-surgery patients to identify factors that may increase the risk of postoperative delirium — a state of sudden confusion. Researchers are examining whether medications like statins and beta blockers, the use of a heart-lung machine, or the leng…

This study surveys 3,000 people with coronary heart disease who are about to start cardiac rehabilitation for the first time. Participants choose from 15 common questions about rehab—covering its purpose, methods, benefits, risks, and cost—or write their own. The goal is to under…

This trial investigates whether a short stay at high altitude (up to 3,545 meters) is safe for people with asymptomatic moderate or severe aortic stenosis. Participants will undergo heart tests—including ECG, echocardiography, and exercise stress tests—both at low altitude and af…

This study investigates whether systemic ozone therapy, used for conditions like chronic pain and osteoarthritis, damages the corneal endothelium—the eye's inner layer that keeps the cornea clear. Researchers will compare 48 patients receiving ozone therapy with 48 healthy matche…

This study looked at how sleep, body clocks, and daily habits affect nighttime blood pressure in Black adults. Researchers monitored 30 participants in a lab for a week to measure blood pressure changes. The goal is to find better ways to treat high blood pressure by targeting sl…

This study analyzes data from over 3 million patients in China's Chest Pain Center registry to understand how people with acute chest pain are diagnosed and treated in real hospitals. It focuses on conditions like heart attacks, unstable angina, aortic dissection, and pulmonary e…

This study tests a two-year educational program for medical and physician assistant students in rural areas. The curriculum includes classroom sessions, simulations, and community rotations to improve teamwork skills. Researchers measure changes in knowledge, attitudes, and team …

This study investigates whether women who had high blood pressure during pregnancy (hypertensive disorders) show differences in brain health in midlife compared to those with normal pregnancies. Participants undergo MRI scans, blood tests, cognitive assessments, and sleep monitor…

This study compares two ways to access blocked leg arteries during a procedure to restore blood flow: through the arm (brachial artery) or the groin (femoral artery). The goal is to see which approach leads to fewer complications, such as bleeding or artery damage. Participants a…

This study investigates whether a blood test measuring how platelets clump under high shear forces can distinguish a first acute coronary syndrome from a recurrent one. Researchers will enroll 97 adults with unstable angina or early heart attack. The goal is to see if this test o…

This study looks at whether a substance in the blood called suPAR can help predict serious health events in people with severe aortic stenosis or regurgitation. Researchers will measure suPAR levels and track participants for two years to see if higher levels are linked to death,…

This study looks at health records of nearly 150,000 people who had knee replacement surgery to see if real-world data can reproduce the findings of a previous clinical trial (RECORD3). The researchers compare two blood thinners, rivaroxaban and enoxaparin, to see which better pr…

This study looks at two medicines, alirocumab and inclisiran, that help lower bad cholesterol (LDL-C) in people with heart disease. Researchers will use real-world data from about 124 patients to see which drug reduces cholesterol more over time. The goal is to understand how the…

This study is not testing a new treatment. Instead, researchers are checking whether information from healthcare claims (like insurance records) can produce the same results as a famous clinical trial called RECORD1. They are looking at data from over 89,000 people who had hip re…

This study will collect routine data from 100 adult ICU patients to build a machine learning model that predicts low blood pressure (hypotension) up to 30 minutes before it happens. The model uses non-invasive vital signs, heart rate, medication records, and fluid balance. No tre…

This study looks at how often chronic kidney disease (CKD) is diagnosed in adults with high blood pressure who have early signs of kidney trouble but no prior CKD diagnosis. Researchers will review medical records and follow patients over time to see how many are formally diagnos…

This study examines the best time to start blood thinners in women who have had severe bleeding after childbirth. Researchers are looking at whether starting blood thinners within 24 hours or later affects the risk of blood clots or further bleeding. The goal is to find a balance…

This study uses French national health data to compare the risk of major heart problems—like heart attack, stroke, and death—in people with Takayasu arteritis versus similar people without the disease. It also looks at how steroid use may affect these risks. The goal is to better…

This study investigates how a high-salt diet versus a low-salt diet influences blood pressure and the immune system in middle-aged adults. Participants follow each diet for one week while their blood pressure and inflammatory markers are measured. The goal is to understand why so…

This study tests whether a tool called the HEART score can accurately predict the risk of serious heart problems in people who come to the emergency room with chest pain. The HEART score uses medical history, EKG results, age, risk factors, and a blood test to classify patients a…

This study looks at whether cardiac autonomic neuropathy (nerve damage that affects heart rate control) changes the heart's electrical recovery time (QT interval) in people having coronary artery bypass surgery. Researchers will test nerve function before surgery and measure hear…

This study looks at whether the neck-to-waist ratio can help identify patients with high blood pressure and a specific type of heart attack. Researchers measured body shapes of 238 adults arriving at the emergency room with chest pain. The goal is to see if simple body measuremen…

This completed pilot study tested a 6-week web-based program called Mind Your Heart in 37 adults who were university employees. The program combined DASH diet education with mindful eating training to improve eating habits and health measures like blood pressure and cholesterol. …

This study examined bleeding inside the heart muscle (intramyocardial hemorrhage) in 60 patients who had a severe type of heart attack called STEMI. Researchers compared two treatment strategies: giving clot-busting drugs followed by a procedure to open the artery, versus going s…

This study looked at how moderate aerobic exercise affects blood pressure in people with hypertension living in cold regions. Researchers measured changes in blood pressure, heart rate variability, and stress-related markers after 16 weeks of exercise. The goal was to understand …

This study looked at 110 adults having nose surgery (septoplasty) to see if different blood pressure targets during surgery affect kidney injury. Patients were split into two groups: one with a lower blood pressure target (50-57 mmHg) and one with a higher target (58-65 mmHg). Ki…

This study looked at whether a special ultrasound check (called VExUS) can help doctors set the ideal dry weight for people on hemodialysis. The idea is that by spotting hidden fluid buildup, doctors can safely remove more fluid during dialysis to better control blood pressure. T…

This study aims to identify short-term triggers of acute ischemic stroke caused by large vessel occlusion, a severe type of stroke. Researchers will ask 302 patients about their exposure to potential triggers—such as infection, mood changes, smoking, alcohol, diarrhea, and extrem…

This study looked at how two types of drug-coated heart stents (Orsiro and Resolute Integrity) heal inside the arteries of 50 people with stable heart disease. Researchers used a special camera to check the healing 4 months after the stents were placed. The goal was to see if one…

This study looked at 100 people with coronary artery disease who had a heart procedure through the wrist. Half got a short sheath and half got a long sheath. The goal was to see which one leads to fewer blockages in the radial artery. Researchers used ultrasound to check for bloc…

This completed study looked at 172 patients who received either a new-generation biological aortic valve or a traditional one during heart surgery. Researchers tracked survival and valve function over five years to see how the newer valves compare. The goal is to provide real-wor…

This completed study analyzed microRNAs in carotid artery plaques from 30 patients who had surgery to remove them. Researchers compared plaques from people who had already had a stroke (symptomatic) with those who had not (asymptomatic) to see if certain microRNAs are linked to s…

This study follows 200 adults who have elective coronary bypass or heart valve surgery to see how their physical abilities, lung function, and muscle strength change after the operation. Researchers measure walking speed, balance, handgrip strength, and breathing tests before and…

This study looks at whether special pacing signals from a pacemaker can improve heart function and lower blood pressure in people who need a pacemaker and also have high blood pressure. Researchers will measure heart pressure and volume using a thin catheter inside the heart. The…

This study looks at whether the position of a pacemaker lead in the right ventricle can improve how well the BackBeat Moderato system controls blood pressure. Five people with hypertension who already have a pacemaker will have their heart pressures and volumes measured with the …

This study follows 150 people with bicuspid aortic stenosis—a narrowed heart valve present from birth—who receive a transcatheter aortic valve replacement (TAVI) using the Evolut Pro or Evolut R XL device. Researchers will measure how well the valve works over time, including blo…

This completed study looked at whether four easy-to-use nutrition scoring tools (GNRI, MNA-SF, PNI, and NAF) can predict serious lung complications after heart surgery in 217 patients aged 60 and older. Researchers tracked problems like pneumonia, blood clots in the lungs, and ne…

This completed study observed over 4,500 adults with atherosclerotic cardiovascular disease who had never had a heart attack or stroke. Researchers compared those taking alirocumab (a cholesterol-lowering drug) to those not on similar therapy, using real-world data to see if the …

This study looked at whether using concept maps—diagrams that show how ideas connect—helps third-year medical students learn and remember information better. 26 students were split into three groups: one with no concept map, one with a map made by the teacher, and one where stude…

This study tested whether a new 3D ultrasound technique can predict how well patients with pulmonary hypertension will do. Researchers followed 150 patients for six months, collecting heart images and tracking deaths and hospitalizations. The goal was to see if this non-invasive …

This study tests whether pharmacists using a generative AI tool (ChatGPT) can provide more accurate and complete medication counseling compared to standard practice. The trial involves 136 adults with chronic conditions like diabetes, high blood pressure, or asthma who are pickin…

This study tested whether screening high-risk patients for hidden peripheral arterial disease using a simple ankle blood pressure test is cost-effective. Over 600 patients were involved, and researchers compared different screening and counseling strategies. The goal was to see i…

This study looked at whether a quick bedside test (Hemochron Jr) gives the same results as standard lab tests for measuring blood clotting in people having planned heart bypass surgery. Twenty patients were tested before and after being placed on a heart-lung machine. The goal wa…

This study tested a skin sensor that measures carbon dioxide (CO2) levels continuously during exercise, comparing it to standard blood tests. Researchers included 140 healthy volunteers and people with lung or heart conditions. The goal was to see if the sensor could accurately t…

This study tested a simple flowchart to help doctors monitor and manage heart conduction problems after transcatheter aortic valve replacement (TAVR). The goal was to see if this approach could safely reduce the need for intensive care and permanent pacemakers. Researchers follow…

This study tested whether the Corsano CardioWatch 287-2, a smartwatch that measures blood pressure using light sensors, can accurately track blood pressure changes in people starting or adjusting their blood pressure medication. Eighty adults with uncontrolled high blood pressure…

This study looked at how doing isometric (static) exercises with a cuff that limits blood flow affects blood pressure and heart function. Twenty-one healthy young adults did exercises under three conditions: no cuff, a wide rigid cuff, and a narrow elastic band. The goal was to s…

This study reviewed the records of 150 adults who had surgery to clear blood clots from the lung arteries. Researchers wanted to see who developed kidney injury within two days after surgery and what factors raised that risk. They looked at things like how long the patient was on…

This completed study observed 528 adults who had heart surgery and were admitted to the intensive care unit (ICU). Researchers tracked deaths, serious complications like stroke or infection, and patient details to identify risk factors. The goal is to use this information to impr…

This completed study reviewed the medical records of 210 people with aortitis (inflammation of the aorta) or retroperitoneal fibrosis (scar tissue in the abdomen). The goal was to find patterns in symptoms, lab tests, and imaging that could help doctors tell different types of th…

This study looked at 75 older adults with suspected normal pressure hydrocephalus, a condition that can cause a reversible form of dementia. Researchers used a combination of fluid infusion tests and special MRI scans to better understand how brain fluid and pressure interact. Th…

This study looked at small molecules called microRNA in the blood and in plaques removed from the carotid arteries of 14 adults during surgery. The goal was to find new biomarkers that could help understand or track carotid artery disease. The study did not test any treatment, bu…

This study tested a new strategy for collecting patient-reported outcome measures (PROMs) to make them more relevant and less burdensome. Researchers compared usual PROMs with an enhanced version in 200 English- and Spanish-speaking patients. The goal was to see if the new approa…

This study tested whether specially designed educational videos, sent through a mobile messaging app, could help people with coronary heart disease improve their fitness and heart health knowledge during a 12-week home-based cardiac rehabilitation program. Twenty-one participants…

This study looked at 49 adults aged 30-65 who had a first heart attack about 4 months earlier. Researchers used brain scans to see if changes in the brain's blood vessels or structure are linked to memory or thinking problems. The goal is to better understand these issues and hel…

This study looked at damage to the protective lining of blood vessels during heart bypass surgery. Researchers measured a substance called syndecan-1 in the blood of 147 patients to see when and why this damage happens. The goal was to understand how surgery affects the body and …

This study looked at how a diabetes medicine called ertugliflozin affects fat tissue around the heart. Researchers took fat samples from 61 adults with type 2 diabetes and heart disease during heart surgery. They tested the fat in a lab to see if the drug improved how the fat cel…

This study looked back at records of 200 adults who had heart valve surgery to see if treating gum disease beforehand lowered their risk of infection or death after the operation. Researchers checked dental X-rays and medical charts from 2015 to 2024. The goal is to understand if…

This study looked at whether applying extra breathing pressure (PEEP) during laparoscopic gallbladder surgery changes the size of the optic nerve sheath, which can indicate brain pressure. Researchers measured the nerve sheath with ultrasound at three points during surgery in 34 …

This study looked at 150 Caribbean Hispanic adults with heart disease or stroke risk who take the blood thinner clopidogrel. Researchers wanted to see if certain gene variants affect how well the drug works. The goal is to understand why some people get less benefit and to pave t…

This completed study looked at 1000 people who had a coronary stent placed to see if a score based on insulin resistance could predict whether the stent would narrow again (restenosis). Researchers measured insulin resistance using routine blood tests and checked for restenosis w…

This study looks at whether bacteria living on heart valves can be detected in the blood. Researchers collected blood, valve tissue, and other samples from 100 patients having aortic valve replacement. The goal is to see if a simple blood test could guide treatment and predict co…

This study tested a new way for doctors to discuss CPR with older, seriously ill patients and their families. Instead of the usual conversation, doctors followed a step-by-step guide that focused on the patient's values and explained why CPR might not help. The goal was to see if…

This completed study looked at how rising temperatures affect people with chronic conditions like heart disease, diabetes, and depression. Researchers in Germany and Italy surveyed 176 patients to see what symptoms they experienced during heat and what protective steps they took.…

This study tested whether a special type of CT scan (dual energy CT) can help doctors better understand and predict the severity of pulmonary hypertension, a condition of high blood pressure in the lungs. Researchers looked at lung images from 60 adults already diagnosed with the…

This study looked at MRI scans from 72 people with two common types of small vessel disease in the brain: hypertensive arteriopathy and cerebral amyloid angiopathy. Researchers focused on tiny fluid-filled spaces in a part of the brain called the dentate nucleus. The goal was to …

This early-phase study in 17 healthy male volunteers examines how a natural sugar modification on the heart hormone ANP changes its effects on blood pressure and fluid balance. Participants receive intravenous infusions of both the sugar-modified and unmodified forms of the hormo…

This study looked at how a sedative called dexmedetomidine affects heart function during off-pump coronary artery bypass surgery. Researchers used ultrasound to measure heart pumping ability in 36 patients with coronary artery disease. The goal was to see if this medication helps…

This study looked at how eye pressure changes when breath-hold divers hold their breath. Forty divers had their eye pressure, oxygen levels, heart rate, and blood pressure measured before, during, and after holding their breath. The goal was to understand these changes and how th…

This study looked at how certain heart devices change a blood-clotting protein called von Willebrand factor. Researchers studied 500 adults with heart failure or aortic stenosis who received a mechanical heart pump or a valve replacement. The goal was to understand when these pro…

This study looked at 70 people who had a tissue heart valve replacement. It compared two common blood-thinning treatments (high-dose aspirin alone vs warfarin plus low-dose aspirin) to see which one better prevented tiny blood clots from traveling to the brain. Researchers used u…

This early-stage trial tested two experimental oral drugs, HL1113-R1 and HL1113-R2, in 35 healthy adults to see if they are safe and how the body processes them. The drugs are being developed for high blood pressure and type 2 diabetes. Participants took the drugs alone and toget…

This study looked at whether having COVID-19 makes people more likely to develop a pulmonary embolism (a blood clot in the lungs). Researchers reviewed medical records of 347 patients who had a CT scan of their lungs. They compared those who tested positive for COVID-19 with thos…

This study tracked 555 adults hospitalized with acute coronary syndrome (a serious heart condition) to see how quickly they called for help and what factors influenced their recovery. Researchers focused on delays in calling an ambulance and how those delays affected short- and l…

This pilot study looked at whether adding genetic risk information to standard heart disease counseling or health coaching helps people make healthier choices. 31 adults at risk for heart disease participated. The goal was to see if this approach is practical and can improve diet…

This early-stage study tested a new drug (HL1113) in 37 healthy adults to see how the body processes it. The drug combines two existing medicines for high blood pressure and type 2 diabetes. Participants took the drug in different ways to compare safety and drug levels. The resul…

This study looked at 81 patients who had coronary artery bypass surgery to find out what factors affect how long they need a breathing tube afterward. Researchers checked things that happened before, during, and after surgery. The goal was to better understand what influences rec…

This study tracked 300 patients with severe aortic stenosis who had a minimally invasive heart valve replacement (TAVI) to see how long they stayed in the hospital and why some stayed longer than 3 days. The goal was to find out what factors, like needing a blood transfusion or a…

This study looked at whether CT scans can help doctors choose the right size for the Perceval sutureless heart valve. The valve is used to replace a leaky aortic valve. Researchers studied 50 patients to see if CT-based sizing leads to good early results after surgery, like prope…

This study followed 326 people newly diagnosed with glaucoma or high eye pressure to see how many got worse over 2 to 4 years of standard monitoring in hospital eye clinics. Researchers measured the rate of disease progression and looked for factors that might predict worsening. …

This study looked at 125 African American adults with high blood pressure to understand what helps them stick to their treatment and stay resilient. Researchers measured blood pressure, quality of life, and self-management behaviors over 6 months. The goal is to find new ways to …

This study looked at how using high-flow nasal oxygen during laryngeal surgery affects the heart and blood vessels. Twenty relatively healthy adults were monitored for changes in heart function compared to standard breathing support. The goal was to understand potential risks, no…

This study looked at over 3,300 people having a heart procedure through the wrist artery. Doctors tested different types of introducers (the tube used to access the artery) to see if a smaller size or a special coating could lower the risk of problems like artery blockage or spas…

This study tested a new way to help women with heart risks like high blood pressure or diabetes get better care after giving birth. Researchers interviewed new moms to understand what makes it hard to attend follow-up visits, then designed a coordinated care system. They tested i…

This study looked at whether using a heart ultrasound probe (TEE) during low-risk coronary artery bypass surgery should be done routinely or only when needed. Researchers enrolled 40 patients and checked if it was possible to randomly assign them to one of two groups. The goal is…

This study looked at whether young men and women respond differently to a simple handgrip exercise for lowering blood pressure. Twenty-nine healthy adults did handgrip training at home for 4 weeks, while researchers measured blood pressure and blood vessel function. The goal is t…

This study looked at whether special ultrasound measurements of the baby's kidney and placenta can help predict health problems in newborns. Researchers compared 114 pregnant women with and without preeclampsia. The goal was to see if these scans could warn doctors about complica…

This study compared two ways to reach the heart's arteries through the wrist during a heart catheterization. The goal was to see if a newer method (distal radial access) causes fewer blockages in the wrist artery than the standard method. 350 adults from three hospitals took part…

This study looked at 405 patients who had a minimally invasive procedure to fix an abdominal aortic aneurysm. Researchers reviewed medical records to see how often complications occurred and which imaging test—ultrasound or CT scan—was better at finding them. The goal was to impr…

This completed study followed over 7,200 heart patients in Tunisia to see how well they stick to their heart medications after a heart attack or procedure. Researchers simply observed and recorded data without giving any new treatment. The goal is to understand real-world medicat…

This completed study looked at how sleep apnea and other health problems like diabetes and high blood pressure affect pain after root canal treatment. 78 adults were divided into three groups: those with sleep apnea, those with diabetes or high blood pressure, and healthy people.…

This study looked at whether indocyanine green angiography (ICGA), a dye-based imaging test, can help doctors assess blood flow in the face after a rare but serious complication from hyaluronic acid filler injections. Researchers reviewed medical records and images from 19 patien…

This study looked at how melatonin, a hormone known for sleep and as an antioxidant, changes during pregnancy. Researchers measured melatonin and its main byproduct in the blood of 60 women across each trimester. The goal was to gather basic information to help design larger stud…

This completed registry followed 300 patients with abdominal aortic aneurysm who were treated with the Nellix® Endovascular Sealing System across 30 international centers. The goal was to see how well the device performs in everyday medical practice, measuring safety and effectiv…

This completed study used artificial intelligence to analyze electrocardiograms (ECGs) and chest X-rays from over 116,000 adults. The goal was to see if combining these routine tests could predict which patients would develop moderate or severe heart valve regurgitation. The rese…

This study checked if certain blood markers can predict serious heart events like heart attack or death within a year after a stent procedure. Researchers measured two types of cells related to blood vessel health in 170 adults scheduled for a stent. The goal was to see if these …

This study measured levels of an inflammatory protein called HMGB1 in 74 children with congenital heart disease and pulmonary hypertension. Researchers compared these levels to those in children with heart disease alone and healthy controls. The goal was to see if inflammation pl…

This study compared two common sedation drugs, propofol and dexmedetomidine, in 65 older adults undergoing a less invasive heart valve replacement called TAVR. The goal was to see which drug leads to better kidney function, less confusion, and fewer complications after the proced…

This study tested a special nursing program that teaches pregnant women with preeclampsia about climate-related health risks, like heat and pollution. 104 women took part, with half receiving the program plus usual care and half receiving usual care alone. The goal was to see if …

This study tested whether a family history app can help doctors collect and use information about patients' family health risks. Over 600 adults aged 30-69 took part. The goal was to see if the app leads to better screening and genetic referrals for conditions like cancer, heart …

This study tested how well an Apple Watch measures heart and fitness data compared to standard medical equipment. About 50 adults with heart conditions or athletes wore the watch during exercise. The goal was to see if smartwatches can reliably help monitor heart disease.

This study looked at whether a special MRI scan (4D Flow) can accurately measure blood flow to the lungs in people with both congenital heart disease and pulmonary hypertension. The standard test for this is a heart catheterization, which is invasive and uncomfortable. The study …

This study tested how easy and acceptable the P-STEP mobile app is for people with chronic conditions like asthma, COPD, heart disease, or diabetes. 178 adults in Leicester, UK used the app for 12 weeks to track their walking and get air quality updates. The main goal was to meas…

This study looked at how two different ways of doing resistance exercise (short vs long sets) affect the heart and blood vessels of postmenopausal women, both with and without high blood pressure. Sixty women participated, and researchers measured things like blood pressure, hear…

This study tested a special MRI that uses inhaled xenon gas to take detailed pictures of lung function in people with pulmonary arterial hypertension (PAH). Ten adults with PAH had four scans over 18 weeks to see how their lungs processed the gas. The goal was to find new ways to…

This study compared two non-invasive blood pressure methods—a finger sensor and a standard arm cuff—against the most accurate method, an arterial line, in 80 patients having non-cardiac surgery. The goal was to see which non-invasive method agrees more closely with the arterial l…

This study looked at how spinal cord epidural stimulation affects bladder, bowel, and blood pressure control in 61 adults with spinal cord injury. Researchers monitored participants in a lab and at home to understand autonomic dysreflexia and test stimulation as a therapy. The go…

This observational study followed 198 adults aged 50–85 with giant cell arteritis or polymyalgia rheumatica to understand how common treatments (glucocorticoids and interleukin-6 inhibitors) affect diabetes risk. Researchers tracked blood sugar levels and other markers over time.…

This study looked at how changing a patient's position during major abdominal cancer surgery affects their heart function and vital signs. Researchers used a non-invasive esophageal Doppler monitor to measure cardiac output in 80 patients undergoing either laparoscopic or open su…

This study looked at whether measuring carbon dioxide in a patient's breath at rest (PETCO2) can help predict lung and heart complications after major vascular surgery. Researchers studied 91 older adults who were scheduled for aortobifemoral bypass surgery. The goal was to see i…

This completed Phase 4 trial looked at how evolocumab (Repatha), a cholesterol-lowering drug, affects markers of inflammation and blood clotting in 41 people with type 2 diabetes and heart disease. Participants received either evolocumab or a placebo injection every 4 weeks for 1…

This study looked at 150 people with coronary artery disease who had bypass surgery, comparing those with and without diabetes. Researchers measured the fat around the heart (epicardial fat) and checked how it relates to death and heart problems after surgery. They also tested if…

This study looked at 26 people with peripheral arterial disease (PAD) to see how arm exercise changes oxygen levels in their leg muscles. Participants used an arm ergometer while a sensor measured calf oxygen saturation. The goal was to understand why arm training can improve leg…

This study looked at 70 adults having open heart surgery (aortic valve or bypass). It compared a newer, smaller heart-lung machine to the standard one. The goal was to see which method better protects the body's tissues and the brain during surgery. Results will help doctors choo…