New drug shows promise for rare, destructive blood vessel disorder

NCT ID NCT04258046

First seen May 02, 2026 · Last updated May 08, 2026 · Updated 2 times

Summary

This study tested the drug trametinib in 25 people aged 12 to 60 with complicated arteriovenous malformations (AVMs)—abnormal blood vessel tangles that can cause bleeding, pain, and heart problems. The goal was to see if the drug could shrink the malformations and improve symptoms. Participants took trametinib by mouth, and doctors monitored their response using scans and quality-of-life measures.

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Contacts and locations

Locations

  • Pediatric Dermatology Clinic at Stanford Children's Hospital

    Palo Alto, California, 94304, United States

Conditions

Explore the condition pages connected to this study.