Stress echo could unmask hidden heart valve disease in amyloidosis patients
NCT ID NCT06372301
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at 15 patients with a rare heart condition called wild-type transthyretin amyloid cardiomyopathy (ATTRwt) who also had signs of aortic stenosis. Researchers used dobutamine stress echocardiography—a test that uses a drug to make the heart pump harder while imaging it—to see if it could accurately measure the severity of the valve narrowing. The goal was to compare this non-invasive method with the standard invasive measurement to improve diagnosis and avoid unnecessary procedures.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Dobutamine (a heart-stimulating drug used during stress echocardiography)
- What this could lead to
- If successful, this could provide a reliable, non-invasive way to diagnose severe aortic stenosis in patients with ATTR amyloidosis, reducing the need for invasive procedures.
- What could go wrong
- This is a small, completed study with only 15 participants, so results may not apply to everyone. The test may still be less accurate than the gold-standard invasive measurement.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for AORTIC STENOSIS are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Department of Cardiology, Aarhus University Hospital
Aarhus, 8200, Denmark
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a daily pill keep a rare heart disease in check for the long haul?
- AI ultrasound could unmask silent heart disease in seniors
- Heart valve fix without the hospital stay? trial tests Same-Day discharge
- Can a wearable monitor prevent heart emergencies after valve replacement?
- Mountain air or heart risk? trial asks if high altitude is safe for aortic stenosis patients.
- Blood test could predict clot risk after heart valve surgery