Arterial disorder

This phase 2 trial tested an experimental biologic called KER-012 in 113 adults with pulmonary arterial hypertension (PAH), a serious lung condition that makes it hard to breathe. Participants received either KER-012 or a placebo as a shot every 4 weeks, on top of their usual PAH…

This study tested whether a 14-day course of hydrochlorothiazide (a water pill) could prevent high blood pressure from returning after delivery in women with preeclampsia or gestational hypertension. Over 450 women were planned, but the trial was stopped early. The main goals wer…

This study tested whether a 6-month program of nurse-led phone calls could help women with uncontrolled high blood pressure take their medication as prescribed. The program included 7 phone calls to address barriers to medication adherence. Only 14 women enrolled before the study…

This study compared two antiplatelet drug regimens after transcatheter aortic valve implantation (TAVI) for aortic stenosis. One group received ticagrelor alone, the other received aspirin plus clopidogrel. The goal was to see which caused fewer serious complications like bleedin…

This trial tests a special pacemaker called the Moderato System in people who need a pacemaker and have high blood pressure that is hard to control with medication. The device is implanted like a regular pacemaker and may help lower blood pressure by adjusting the heart's pacing.…

This study looked at whether the drug riociguat could improve right heart size and function in people with two types of pulmonary hypertension (PAH and CTEPH). It planned to enroll 30 adults, but was terminated early, so results are limited. The goal was to use echocardiograms to…

This trial tests a special pacemaker-like device, the Moderato System, designed to lower blood pressure in people who have resistant hypertension and already need a dual-chamber pacemaker. Participants are randomly assigned to have the device's blood-pressure-lowering feature tur…

This study follows 197 people who previously had a procedure called TCAR to treat carotid artery disease. Researchers will check for strokes, deaths, and whether the artery narrows again over 2 to 5 years. The goal is to see how well the treatment holds up over time.

This early study tested a new cell therapy called LUCAR-G79 in just 3 adults with severe autoimmune diseases that did not respond to standard treatments. The therapy uses specially engineered immune cells to target and potentially calm the overactive immune system. The main goals…

This trial tests whether performing balloon aortic valvuloplasty without the blood thinner heparin reduces serious bleeding and blood vessel complications. About 94 adults with severe, symptomatic aortic stenosis will be randomly assigned to receive either heparin or a placebo du…

This study tests whether injections of cells from donated human placentas can help heal foot ulcers in people with diabetes. The trial includes patients with and without peripheral artery disease, a common complication that slows healing. Participants receive either the cell trea…

This study tests whether using a special tube (EZ-Blocker) to collapse one lung during heart bypass surgery can reduce fluid buildup and the need for chest drains. The trial includes adults having planned coronary artery bypass surgery that uses the internal thoracic artery. The …

This study looked at how different amounts of potassium supplements affect blood pressure in adults with high blood pressure. Researchers aimed to find the best potassium level to help lower blood pressure. The study was stopped early and included 25 participants.

This Phase 3 trial tested the drug sotatercept in 321 people newly diagnosed with intermediate- or high-risk pulmonary arterial hypertension (PAH). Participants received either sotatercept or a placebo added to their usual PAH therapy. The goal was to see if sotatercept could del…

This study looked at two ways to manage older patients (80+) who had a mild type of heart attack (NSTEMI). One group got routine angiography (an invasive look at the heart's arteries), while the other group first had a non-invasive imaging test (SPECT or stress echo) and only got…

This study looked at the long-term safety of an inhaled drug called treprostinil in people who have both pulmonary hypertension (high blood pressure in the lungs) and COPD. It included 41 adults who had already completed a previous study. The trial was terminated early, and the m…

This study tested an experimental drug called AMAG-423 (Digoxin Immune Fab) in pregnant women with severe preeclampsia, a dangerous condition of high blood pressure during pregnancy. The goal was to see if the drug could reduce serious health problems in babies, such as bleeding …

This study tested whether giving a clot-busting drug (tenecteplase or alteplase) within 4.5 hours of an eye stroke could restore vision. Eye stroke, or central retinal artery occlusion, is a blockage in the eye's main artery that often causes permanent vision loss. The trial aime…

This study compared two different doses of epinephrine (0.5 vs 1.0 mcg/kg) given to children in the intensive care unit for life-threatening low blood pressure. The goal was to see which dose raised blood pressure more effectively. Only 15 children were enrolled before the study …

This study tested two different combinations of eye drops to lower eye pressure in people with open-angle glaucoma or ocular hypertension. The goal was to see which combination worked better over 90 days. The study was stopped early and included 28 participants.

This study looked at whether taking high doses of statins for two weeks before carotid artery surgery could prevent memory and thinking problems after the operation. It included 31 adults with severe carotid artery narrowing. The study was stopped early, so the results are limite…

This study tested whether taking the blood thinner rivaroxaban for 7 days after heart catheterization via the wrist could prevent the wrist artery from becoming blocked. About 930 adults were planned, but the trial was stopped early. The main goal was to see if the artery stayed …

This study tested whether personalizing blood-thinning drugs based on a patient's genetics and risk factors could reduce bleeding after a heart attack. It enrolled 39 patients who had already been on standard dual therapy for a year. The trial was terminated early, so the finding…

This study compared two drugs, obinutuzumab and rituximab, for treating a rare autoimmune disease that inflames blood vessels (ANCA-associated vasculitis). The goal was to see if obinutuzumab could help more patients achieve remission and clear disease markers. However, the trial…

This study looked at whether long-term treatment with vitamin C+E and statins could reduce artery spasms and plaque buildup in people with variant angina, a type of chest pain. The trial planned to enroll 320 adults aged 30 and older, but it was terminated early. The main goal wa…

This study tested whether hydroxychloroquine, a drug used for lupus and arthritis, could help control ANCA vasculitis—a group of autoimmune diseases that cause blood vessel inflammation. Adults with mild disease activity were randomly assigned to receive hydroxychloroquine or a p…

This study tested a drug called CardiolRx in 90 hospitalized COVID-19 patients who also had heart disease or risk factors like diabetes or high blood pressure. The goal was to see if the drug could lower the chance of death, needing intensive care, or having heart problems. The t…

This phase 3 trial tested a new drug, abelacimab, against a standard blood thinner (dalteparin) to prevent dangerous blood clots from returning in people with gastrointestinal or genitourinary cancers. The study enrolled 417 adults with advanced cancer and a recent clot. It was t…

This study looked at a hybrid approach for treating multiple blocked heart arteries: a minimally invasive bypass for the main artery plus stents for others. Only 6 people took part before the study was stopped early. The goal was to see if this combination is safe and effective i…

This study tested whether taking people with severe stroke symptoms directly to the angio-suite for clot removal, instead of first doing a CT or MRI scan, leads to better recovery at 3 months. About 120 adults aged 18-85 with severe stroke were randomly assigned to either direct …

This study tested whether adding anakinra, an anti-inflammatory drug, to standard steroid treatment could lower relapse rates in people with giant cell arteritis, a blood vessel disease. The trial planned to include 70 adults over 50 but was stopped early with only 30 participant…

This study looked at the long-term safety and effectiveness of the STREAMLINE® Surgical System in people with open-angle glaucoma. It included 17 patients who had already taken part in an earlier trial of the same device. The goal was to see if the device continued to safely lowe…

This study looked at the long-term safety and effects of a procedure called renal denervation in 9 patients with resistant hypertension (high blood pressure that doesn't respond to multiple medications). The procedure uses a device to disrupt certain nerves in the kidney arteries…

This study tested a special balloon that uses sound waves (shockwaves) to crack open hard calcium blockages in the leg arteries of people with critical limb ischemia, a condition where poor blood flow can lead to pain, wounds, or even amputation. The goal was to see if the balloo…

This study tested a new way to manage blood pressure in new mothers with severe postpartum preeclampsia. Participants received standard blood pressure medications, but one group had personalized blood pressure targets based on real-time brain monitoring. The goal was to keep bloo…

This study looked at whether using a combination of weight-loss medications could help people with obesity lose weight and improve the health of their blood vessels. It involved 128 adults aged 40-75 who were obese and had at least one heart risk factor. The study was stopped ear…

This study tested a new blood thinner, abelacimab, against the standard drug apixaban in about 1,150 people with cancer who had a blood clot. The goal was to see which drug better prevented new clots and caused less bleeding. The study was stopped early, but the results may still…

This study looked at whether screening people for high platelet reactivity (a condition where blood clots easily) before leg artery procedures could improve outcomes. It involved 31 adults with peripheral artery disease who were scheduled for angioplasty or stenting. The trial wa…

This study looked at the long-term safety of the drug LTP001 in people with pulmonary arterial hypertension (PAH), a serious lung condition. It was an open-label extension for patients who had completed a previous study. However, the study was terminated early, and no one reached…

This study tested whether kidney transplant recipients with high blood pressure could better control their condition by monitoring their blood pressure at home, compared to standard clinic visits. The trial planned to enroll many participants but was stopped early after only 21 p…

This study tested the drug riociguat in people with early pulmonary vascular disease, a condition where blood vessels in the lungs narrow, making the heart work harder. The trial included 35 adults with connective tissue disease or an inherited form. Participants received either …

This pilot study tested three common blood pressure medications—amlodipine, chlorthalidone, and losartan—in 36 young adults aged 18-40 with hypertension. Participants took the drugs at home and monitored their blood pressure regularly. The goal was to see which drug works best an…

This study tested an experimental drug called LTP001 in 47 people with pulmonary arterial hypertension (PAH), a condition where high blood pressure damages the arteries in the lungs. The goal was to see if LTP001 could improve blood flow and exercise ability. However, the trial w…

This early study tested a new procedure called SESAME that uses a wire threaded through blood vessels to slice away excess heart muscle in people with hypertrophic cardiomyopathy. Only one adult participated before the study was terminated. The goal was to see if the technique co…

This study tested a smartphone-based program to help stroke survivors with high blood pressure lower their risk of another stroke. The program involved tracking blood pressure and getting tailored reminders. The study was terminated early, so results are limited.

This study tested a device called Leaflex™ Performer, which is threaded through a blood vessel to the heart to score and loosen calcium buildup on stiff aortic valves. It was designed for people with severe aortic stenosis who cannot have standard valve surgery or replacement. Ho…

This study tested an experimental drug called REGN5381 in 34 adults with uncontrolled hypertension (high blood pressure despite taking one or more blood pressure medications). The drug is a monoclonal antibody designed to activate NPR1 receptors, which may help lower blood pressu…

This study tested a special contact lens that slowly releases the glaucoma drug latanoprost, aiming to replace daily eye drops. Only one person enrolled before the study was stopped early. The goal was to check safety and whether the lens could lower eye pressure, but no conclusi…

This study tested a gene therapy called VM202 to help heal chronic foot ulcers in people with diabetes and poor leg circulation. The treatment was given as injections into the calf muscle. The study was stopped early after enrolling only 44 participants, so results are limited.

This study looked at how well the BIOFREEDOM stent works in everyday medical practice for people with narrowed heart arteries. Researchers planned to track 218 patients to see rates of death, heart attack, or need for repeat procedures. The study was stopped early, so results are…

This study looked at whether a procedure to remove large blood clots from the brain could help people who had a severe stroke. It included 335 adults with a large stroke who could be treated within 7 hours. The goal was to see if the procedure reduced disability compared to stand…

This study tested whether giving lithium carbonate before carotid artery surgery could reduce brain damage and confusion after the operation. The trial planned to include 107 adults undergoing elective carotid surgery, but it was terminated early. The goal was to see if lithium c…

This was a very early Phase 1 study testing a single injection of ART101 in people with high blood pressure. The trial was stopped after only 1 participant was enrolled, so no meaningful results are available. The goal was to check safety and how the drug moves through the body.

This trial tested a stent-retriever device to remove blood clots from the lungs in people with acute pulmonary embolism. Only one participant was enrolled before the study was terminated. The goal was to see if the device could reduce heart strain and avoid major complications wi…

This study tested a new type of stent (BiOSS LIM C) designed for blockages at the left main coronary artery fork. The trial enrolled 130 people with severe blockages. Unfortunately, the new stent did not work as well as the standard stent, and the study was stopped early.

This was a very early (Phase 1) study testing a drug called HS135 in obese patients who have both pulmonary hypertension and a type of heart failure called HFpEF. The trial was terminated after enrolling only 4 people, so we have no useful information on whether HS135 is safe or …

This study tested a drug called KBP-5074 in 652 adults with moderate-to-severe chronic kidney disease and high blood pressure that was not controlled by at least two other medications. Participants received either KBP-5074 or a placebo daily for up to 52 weeks to see if the drug …

This study tests new methods to measure pressure, blood flow, and blockage size in heart arteries. Researchers want to see if these measurements can better identify which blockages are serious enough to cause heart damage. The study involves people with known or suspected coronar…

This Phase II study tested a radioactive tracer called 68GaNOTA-Anti-MMR-VHH2 to see if it can light up certain immune cells (macrophages) on PET scans. The trial included 29 people with head and neck cancer, lymphoma, atherosclerosis, or sarcoidosis. The goal was to see if the t…

This study looked at whether a special CT scan called FFR-CT can help emergency room doctors better diagnose coronary artery disease in patients with chest pain. The plan was to compare treatment decisions made with and without the FFR-CT results. However, the study was stopped e…

This study tested a new stress echocardiography method using regadenoson and atropine to diagnose coronary artery disease. It involved 45 adults scheduled for cardiac catheterization. The goal was to see if this faster, radiation-free approach could accurately detect significant …

This study explored whether a special type of MRI using inhaled xenon gas could detect changes in the small blood vessels of the lungs in people with pulmonary hypertension. The goal was to see if this imaging method could track disease progression or response to treatment. Howev…

This study looked at whether measuring the speed of pulse waves in arteries, combined with machine learning, could improve prediction of significant coronary artery disease in people with chest pain or shortness of breath. Researchers planned to enroll 156 patients undergoing a h…

This study tested a special PET scan tracer to see if it can find fresh blood clots in people with pulmonary embolism (PE) or deep vein thrombosis (DVT). Six adults with confirmed clots received the tracer within 72 hours of diagnosis. The goal was to compare the PET images with …

This study aimed to see if the CONNEQT Pulse blood pressure monitor gives accurate readings in pregnant women, including those with high blood pressure or pre-eclampsia. Researchers compared it to a standard blood pressure cuff in 41 pregnant volunteers. The study was stopped ear…

This study compared a newer PET heart scan (using XTR004) with a standard SPECT scan to see which gives doctors more confidence in diagnosing borderline blocked arteries. It involved 17 adults with suspected stable heart disease and 30-90% blockages seen on a prior CT scan. The g…

This study looked at whether intensive treatment for gum disease (periodontitis) could prevent dementia in older adults who already have mild cognitive impairment and narrowed neck arteries. Participants received either standard dental care or deep cleaning and root planing. The …

This study tested whether the cholesterol-lowering drug pravastatin could prevent preeclampsia in women who had a previous early preterm delivery due to the condition. The trial planned to enroll 1,550 women but was terminated early with only 102 participants. Because it stopped …

This study tested whether taking roxadustat before heart bypass surgery could prevent sudden kidney damage, a common complication. The trial enrolled 98 adults aged 18-80 with planned bypass surgery. The drug aims to help tissues handle low oxygen better. However, the study was t…

This study tested whether a drug called Polaramine can prevent dangerous drops in blood pressure when patients come off a heart-lung machine during aortic valve replacement. 18 adults took part. The goal was to see if the drug helps the body keep a stable blood pressure after sur…

This study tested whether injecting a long-acting numbing drug (liposomal bupivacaine) during leg artery surgery could lower the amount of narcotics patients need during and after the procedure. The trial planned to enroll adults having elective lower extremity revascularization,…

This study aimed to compare two blood pressure medications—oral nifedipine (a pill) and intravenous labetalol (given through a vein)—for treating dangerously high blood pressure in women who have just given birth. The goal was to see which drug lowers blood pressure faster. Howev…

This small pilot study tested whether placing critically ill patients with low blood pressure in a head-down tilt (Trendelenburg) position could improve organ function by reducing the need for fluids and blood-pressure-raising drugs. The study included 10 sedated, ventilated pati…

This study tested whether adding a video to standard discharge education helps patients who have had coronary artery bypass graft (CABG) surgery feel more satisfied and less anxious. 120 patients were randomly assigned to receive either standard education, a standard video, or a …

This study tested whether a device called Nanodropper, which makes smaller eye drops, works as well as standard eye drops for lowering eye pressure in people with glaucoma or ocular hypertension. The study enrolled 16 adults who already used a common glaucoma drop. The goal was t…

This study looked at whether a preservative-free eye gel called IRIDIUM® could help relieve dry eye symptoms in people with glaucoma or high eye pressure who were already using multiple eye drop medications. The goal was to see if the gel improved comfort and quality of life. The…

This study looked at whether slow, deep breathing for 10 minutes daily could help lower blood pressure in pregnant women with pregnancy-induced hypertension. Only 1 participant was enrolled before the study was terminated, so no meaningful conclusions can be drawn. The goal was t…

This study looked at whether measuring a natural clot-busting substance (t-PA) released from heart arteries could predict future heart attacks or death in people with mild to moderate coronary artery disease. Researchers gave a small dose of bradykinin into the heart artery durin…

This study looked at how the heart's pumping function recovers after a short, controlled blockage of a coronary artery using a balloon. Six adults with stable coronary artery disease undergoing angioplasty had a balloon inflated in their artery for 90 seconds. Researchers measure…

This study tested a new, non-invasive way to measure blood flow in the legs of people with peripheral artery disease (PAD). Researchers compared the new method to standard ultrasound in 29 patients scheduled for a procedure to open blocked leg arteries. The goal was to see if the…

This study looked at how two common pain relievers—celecoxib (a Coxib) and naproxen (an NSAID)—affect blood clotting in people with rheumatoid arthritis who also have heart disease or are at high risk for it. All participants took low-dose aspirin daily. The goal was to see if on…

This study aimed to see if a new device called the EyeCheck monitor can measure eye pressure as accurately as standard tools in people with glaucoma or suspected glaucoma. Twenty-two participants used the device during a clinic visit. The study was stopped early, so results are l…

This study aimed to see if a blood test measuring platelet function could predict neurological events like stroke in people undergoing carotid artery surgery. Researchers planned to enroll 650 patients but the study was terminated early. The test uses a device called Multiplate t…

This study tested whether starting with a low-cost coronary calcium scan (about $100) could safely avoid the need for a more expensive heart stress test (over $1,500) in people with chest pain. Researchers planned to enroll 48 adults aged 50 and older with suspected heart disease…

This study aimed to see if the heart-lung machine used during heart surgery changes blood flow in the gut. Researchers checked blood flow under the tongue as a way to measure gut health. The study was stopped early and included only 21 adults having aortic valve replacement. It w…

This study looked at using a special wire that measures blood pressure inside heart arteries (called FFR) to help doctors decide which blockages to treat with stents. It included 438 people with two or more blockages in the same artery. The study was stopped early, so the results…

This study was a large registry that planned to follow 180,000 patients in Germany with aortic valve problems (leaky or narrowed valves). The goal was to compare newer, less invasive treatments like TAVI with standard open-heart surgery to see which works best and for whom. Resea…

This study looked at whether using a VQ scan (which doesn't use kidney-harming dye) instead of a CT scan can prevent acute kidney injury in emergency patients being checked for lung clots. About 253 adults at risk for kidney problems were enrolled. The trial was terminated early,…

This study tested whether using a special image-guidance system (AxiEM Stealth) helps doctors place a brain drain more accurately at the bedside compared to the usual freehand method. The drain is needed to relieve pressure in the brain. The study included 31 adults who needed th…

This study tested a new blood pressure device called ModPG3 on 7 newborns and infants to see if it meets international accuracy standards. The device uses two methods to measure blood pressure during cuff inflation and deflation. The trial was terminated early, so results are lim…

This study tested whether a 16-week program of yoga and lifestyle changes could affect gene activity (micro RNA) and heart disease risk factors in 16 adults with coronary artery disease. Participants had either undergone a heart procedure or had non-obstructive heart disease with…

This study tested whether a device that uses near-infrared light (NIRS) can measure blood flow in the remaining leg after a below-knee amputation better than the standard method (TcPO2). Researchers planned to include 50 patients in two groups: those with a permanent prosthetic l…

This study tested whether fentanyl, a painkiller used during heart stent procedures, reduces the effectiveness of ticagrelor, a blood thinner given to prevent clots. Researchers compared crushed versus whole ticagrelor pills in 45 patients. The trial was stopped early, so results…

This study looked at whether a non-invasive cycling test, combined with a muscle oxygen monitor (NIRS), could detect a condition called flow limitation in the iliac artery (FLIA) in endurance athletes. FLIA can cause leg pain and limit performance, and early detection is difficul…

This study looked at whether adding a special imaging test (Cytocam-IDF) to standard monitoring during major vascular surgery could help patients leave the hospital sooner. The trial was planned for more participants but was stopped early after only 22 people took part. Because i…

This study aimed to see if a new urine test can accurately tell whether people with type 2 diabetes are taking their medications as prescribed. Researchers planned to compare the urine test results with standard methods like questionnaires and pharmacy records in 90 participants.…

This study looked at why erythropoietin (EPO), a drug used to treat anemia, can raise blood pressure in people with chronic kidney disease. Researchers planned to enroll 160 participants but stopped early with only 27. The goal was to measure changes in blood pressure and blood v…

This study tested two new algorithms (SureBP and StepBP) in a blood pressure device to see if they measure blood pressure accurately in adults and children ages 3 and up. The goal was to check if the device meets international accuracy standards. The study was terminated early, s…

This study tested a non-invasive blood pressure monitor (CNAP) against the standard invasive method (using a needle in the artery) in 20 pregnant women with placenta accreta undergoing scheduled C-sections. The goal was to see if the gentler method gives equally accurate readings…

This study aimed to find out how often infections happen after a procedure called TEVAR, which repairs the main artery in the chest. Researchers looked at data from 457 patients who had this surgery in the past five years. They measured infection rates, fever, and lab results to …

This study looked at whether blocking certain nerve signals can improve how the body uses insulin and reduce inflammation in people with obesity and high blood pressure. Ten participants took two drugs—moxonidine and amlodipine—to lower nerve activity. The goal was to see if this…