Big data vs. clinical trials: can insurance records match gold-standard results?
NCT ID NCT07599384
First seen Jun 27, 2026 · Last updated Jul 10, 2026 · Updated 1 time
Summary
This study looks at health records of nearly 150,000 people who had knee replacement surgery to see if real-world data can reproduce the findings of a previous clinical trial (RECORD3). The researchers compare two blood thinners, rivaroxaban and enoxaparin, to see which better prevents blood clots. The goal is not to test a new drug, but to learn whether large databases can reliably mimic controlled trials.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- What this could lead to
- If successful, this could show that analyzing large healthcare databases can reliably reproduce results from controlled trials, potentially speeding up medical research.
- What could go wrong
- This is an observational study using existing data, not a new treatment test. Results may not perfectly match the original trial due to differences in patient populations or data quality.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for DEEP VEIN THROMBOSIS are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Brigham and Women's Hospital
Boston, Massachusetts, 02120, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Simple 5-Step nursing plan could slash deadly clot risk after hip surgery
- Timing of blood thinners after childbirth bleeding may prevent clots without causing more harm
- New fingerstick test for blood thinner monitoring put to the test
- Can insurance records replace clinical trials? huge study puts it to the test
- New Clot-Busting device could ease Long-Term leg pain
- New Finger-Prick test could speed up blood clot diagnosis