Catheter-Directed Clot-Busting may offer safer option for dangerous blood clots in the lungs

This study investigates whether delivering a clot-dissolving drug directly into the lung arteries via a thin tube (catheter) can improve outcomes for people with a serious type of pulmonary embolism (a blood clot in the lung). Participants have intermediate-high risk clots, meaning they are at increased risk of complications but not in shock. Half receive the catheter treatment plus standard blood thinners, and half receive standard blood thinners alone. The study tracks deaths, clot recurrence, and heart or breathing collapse within the first week, along with longer-term recovery and quality of life.