New hope for kids with heart valve disease: mini mechanical valve under study

NCT ID NCT03924661

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is testing a small mechanical heart valve (15mm) in 20 children who need their aortic valve replaced due to disease or damage. The valve is designed to last and is monitored for safety and function over 5 years. Children will need lifelong blood-thinning medication to prevent clots, so this is a disease management approach, not a cure.

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Conditions

The condition(s) this trial relates to.

Aortic Valve Disease aortic valve disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Children's Healthcare of Atlanta

    Atlanta, Georgia, 30322, United States

  • Children's Hospital Los Angeles (USC)

    Los Angeles, California, 90027, United States

  • Children's Medical Center Dallas

    Dallas, Texas, 75235, United States

  • Cincinnati Children's Hospital

    Cincinnati, Ohio, 45229, United States

  • Dell Children's Medical Center

    Austin, Texas, 78723, United States

  • Deutsches Herzzentrum München des Freistaates Bayern

    München, Bavaria, 80636, Germany

  • Herzzentrum Leipzig GmbH

    Leipzig, Saxony, 04289, Germany

  • Medizinische Hochschule Hannover

    Hanover, Germany

  • Sana - Herzchirurgische Klinik Stuttgart GmbH

    Stuttgart, Baden-Wurttemberg, 70174, Germany

  • Sutter Medical Center, Sacramento

    Sacramento, California, 95816, United States

  • University of Mississippi Medical Center

    Jackson, Mississippi, 39216, United States

  • Valley Children's Hospital

    Madera, California, 93636, United States

  • Variety Children's Hospital

    Miami, Florida, 33155, United States

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