Heart valve showdown: which TAVI valve sends fewer particles to the brain?

NCT ID NCT07614100

Not yet recruiting Knowledge-focused Sponsor: Ivan Zeljkovic Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study will compare two common types of heart valves used in TAVI (a procedure to replace a narrowed aortic valve) to see which one sends fewer tiny particles to the brain during the procedure. 80 adults with severe aortic stenosis will be randomly assigned to receive either a balloon-expandable or a self-expanding valve. Researchers will use ultrasound to monitor brain particles before, during, and after the procedure to understand how valve choice affects stroke risk.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Balloon-expandable or self-expanding transcatheter aortic valve
What this could lead to: If it works, this could help doctors choose the valve type that reduces tiny brain particles during TAVI, possibly lowering stroke risk.
What could go wrong: This is a small, early-stage study that only measures microemboli, not actual strokes. The results may not change practice or apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

aortic valve stenosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AORTIC STENOSIS

Contacts and locations

Locations

Sisters of Charity Hospital Zagreb

Zagreb, 10000, Croatia
UH Dubrava

Zagreb, 10000, Croatia

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