New heart valve trial aims to improve Second-Time valve replacements
NCT ID NCT07524595
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This trial is for people whose surgically implanted aortic heart valve has stopped working properly. It compares two types of replacement valves placed through a tube in the leg (TAVI): a newer self-expanding valve (Hydra) versus standard balloon-expandable valves (Sapien or MyVal). The goal is to see which valve allows better blood flow through the heart. About 111 participants will be randomly assigned to receive one of the valve types.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Hydra THV Series (self-expanding valve) and Sapien/MyVal THV Series (balloon-expandable valves)
What this could lead to
If successful, this trial could show that the Hydra valve provides better blood flow than current balloon-expandable valves for patients needing a second valve replacement.
What could go wrong
This is a relatively small, early-stage trial (111 patients) comparing devices, not testing a new cure. Results may not apply to all patients, and there are standard risks of TAVI procedures like bleeding or valve issues.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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University of Galway
Galway, Ireland
Contact Phone: •••-•••-•••• Email: •••••@•••••