Large intestine disorder

This phase 3 trial tests two different ways of using radiation before chemotherapy in people with stage III rectal cancer. One group gets a short course of radiation, the other gets standard chemoradiation, both followed by chemotherapy. The goal is to see if either approach can …

This phase 2 trial is testing whether a short course of radiation followed by a powerful three-drug chemotherapy regimen (FOLFOXIRI) can completely eliminate tumors in people with locally advanced rectal cancer before they undergo surgery. The study enrolls adults aged 18 to 70 w…

This study looks at whether a combination of radiation and chemotherapy can cure low rectal cancer, allowing patients to avoid surgery. About 108 people with early-stage rectal tumors near the anus will receive this treatment. The main goal is to see if the cancer stays under con…

This study tests a new vaccine called Shigella4V2 to see if it can protect people from shigellosis, a severe diarrheal disease. About 120 healthy adults will receive either the vaccine or a placebo and then be exposed to the bacteria in a controlled setting. The goal is to see if…

This study tests a two-dose vaccine designed to prevent diarrhea from two common types of Shigella bacteria in 8,000 children aged 6 months to 5 years in Bangladesh. Half the children get the vaccine, half get a placebo, and researchers track who gets sick over time. The goal is …

This study tests three drugs—durvalumab (an immunotherapy), olaparib (a DNA repair blocker), and cediranib (a blood vessel growth blocker)—in different combinations for people with advanced solid tumors, especially ovarian cancer. The phase 1 part finds safe doses, and the phase …

This study tests an oral drug called TAK-279 (Zasocitinib) in 207 adults with moderate-to-severe ulcerative colitis. Participants take either the drug or a placebo for 12 weeks, then everyone gets the drug for up to a year. The goal is to see if TAK-279 reduces bowel inflammation…

This study offers continued access to the cancer drug ruxolitinib (sometimes combined with other therapies) for people with pancreatic, colorectal, breast, or lung cancer who were already benefiting and stable in a prior Incyte-sponsored trial. Only 10 participants are enrolled, …

This study compares the real-world effectiveness of mirikizumab against standard biologic therapies for adults with ulcerative colitis or Crohn's disease. Researchers will track whether mirikizumab reduces the need for extra medical care, like emergency visits or treatment change…

This early-phase trial is testing whether adding a new targeted drug called adagrasib to two existing cancer drugs (cetuximab and irinotecan) is safe and tolerable for people with advanced colorectal cancer that has a specific genetic change called KRAS G12C. The study will enrol…

This study looks at whether giving an extra dose of the antibiotic cefoxitin during appendix removal surgery can better prevent infections compared to the usual single dose before surgery. Researchers will measure antibiotic levels in blood, fat, and appendix tissue from 46 parti…

This phase 2 trial is testing whether adding the immunotherapy drug durvalumab to the usual chemotherapy and radiation treatment can help people with locally advanced anal cancer stay cancer-free longer. The study includes about 180 adults with stage IIB–IIIC anal cancer. Partici…

This study tests a treatment made from healthy donor stool (MTP-101-C) for cancer patients whose skin or gut side effects from immunotherapy don't get better with steroids. About 30 participants will take the oral capsules to see if the therapy is safe and can calm these side eff…

This early-stage trial tests a personalized treatment for people with metastatic solid cancers that have KRAS mutations. Doctors take a patient's own white blood cells, genetically modify them to recognize and attack KRAS-mutated cancer cells, and return them to the patient along…

This phase II trial is testing whether a combination of talimogene laherparepvec (a modified herpes virus that infects and kills cancer cells) and nivolumab (an immunotherapy drug) can shrink tumors in people with rare skin cancers or lymphomas that haven't responded to standard …

This study tests a new drug, APL-5125, in adults with advanced solid tumors like colorectal, pancreatic, and ovarian cancer. The goal is to see if the drug is safe and can shrink or control tumors. About 100 participants will receive the drug in two phases to find the best dose a…

This early-stage study is testing a new drug, AB801, alone or with other treatments, in about 91 people with advanced cancers (like lung, colon, or breast cancer) that have not responded to standard therapies. The main goal is to check the drug's safety and find the best dose for…

This phase 2 trial is testing whether adding PET-guided radiation and an immunotherapy drug called cadonilimab to standard chemotherapy can shrink tumors better than chemotherapy alone in people with colorectal cancer that has spread to the lining of the abdomen. The study will e…

This trial tests whether giving zinc supplements before and after colonic surgery in children can help protect the gut lining and reduce inflammation. Children aged 1 month to 18 years undergoing colonic surgery with anastomosis will be randomly assigned to receive either routine…

This study tests whether two drugs, fruquintinib and tislelizumab, can control leftover cancer cells in people with colorectal cancer who have completed chemotherapy but still show signs of minimal residual disease (MRD) on a blood test. About 20 adults with stable disease will r…

This early-phase study tests an experimental drug called M9140 in 12 Chinese patients with advanced colorectal cancer that has not responded to standard treatments. The drug works like a guided missile, delivering chemotherapy directly to cancer cells that carry a specific marker…

This study tests a new drug called SHR-8068 combined with other cancer treatments for people with colorectal cancer. The goal is to see if the combination is safe and helps shrink tumors or slow cancer growth. About 200 adults aged 18 to 75 will take part, and they must provide t…

This study tests whether adding new cancer drugs to standard chemotherapy and bevacizumab can better control metastatic microsatellite-stable colorectal cancer. About 61 adults with this advanced cancer will receive different treatment combinations. The goal is to find safer, mor…

This trial is testing an experimental drug called XNW27011 in people with advanced solid tumors, such as pancreatic, lung, ovarian, colorectal, biliary tract, stomach, or gastroesophageal junction cancer, that have not responded to or are not eligible for standard treatments. XNW…

This phase 2 trial tests a new approach for people with locally advanced rectal cancer. Participants first receive a short course of radiation, followed by a combination of immunotherapy (sintilimab and IL-2) and chemotherapy (CAPOX). The goal is to see if this treatment can make…

This early-phase trial tests whether giving two standard chemotherapy drugs (5FU and oxaliplatin) directly into the abdominal cavity is safe for people with colorectal cancer that has spread only to the peritoneal lining. About 24 adults will receive the drugs through a catheter …

This trial asks whether a newer, simpler technique called cold snare polypectomy (CSP) causes less damage to blood vessels under colon polyps than the traditional hot snare method. It involves adults with non-cancerous colon polyps sized 10-19 mm. The study compares the presence …

This study tests whether frozen capsules containing processed stool from healthy donors can help people with mild-to-moderate active ulcerative colitis. Participants will take either the real capsules or a placebo for 12 weeks. The goal is to see if the treatment can bring the di…

This phase II trial is testing whether a blood test that looks for tumor DNA (ctDNA) can help doctors choose between two standard drugs—regorafenib or TAS-102—for people with advanced colorectal cancer that has stopped responding to other treatments. The study will enroll 100 par…

This study tests two different doses of TEV-48574 (duvakitug) given as a shot every 4 weeks to adults with moderate to severe ulcerative colitis or Crohn's disease. Participants who completed a previous 14-week study can join. The goal is to see if the drug can keep the disease u…

This early-phase trial is testing a new drug called enzelkitug, alone or with standard immunotherapies, in people with advanced solid tumors that have not responded to other treatments. The main goals are to check safety, find the right dose, and see if the drug shrinks tumors. A…

This study is testing a minimally invasive weight loss procedure called endoscopic sleeve gastroplasty (ESG) in 12 people who have both obesity and ulcerative colitis and are planning or have had colon removal surgery. The procedure uses a suturing device to reduce stomach size b…

This study explores whether regular aerobic exercise, specifically walking about 300 minutes per week, can change certain biomarkers in the blood that are linked to cancer risk. Participants are adults who have completed all cancer therapy and have either clonal hematopoiesis (a …

This phase 3 trial is testing whether adding the immunotherapy drug nivolumab to standard chemotherapy (carboplatin and paclitaxel) helps people with metastatic anal cancer live longer without their disease getting worse. About 205 adults with inoperable or recurrent anal cancer …

This early-phase trial tests an experimental antibody called GEN1042, given alone or with the cancer drug pembrolizumab (and sometimes chemotherapy), in people with advanced solid tumors like lung, colon, melanoma, head and neck, or pancreatic cancer. The main goals are to check …

This early-phase trial is testing whether a light-activated treatment, called photodynamic therapy (PDT), combined with vitamin D3, can safely treat high-grade anal dysplasia and very early anal cancer. Participants receive a photosensitizing drug that makes abnormal cells sensit…

This phase 3 trial is testing whether adding the immunotherapy drug atezolizumab to standard chemotherapy can help prevent cancer from coming back in people with stage III colon cancer that has a specific DNA repair defect (dMMR). About 712 participants will receive either chemo …

This early-phase trial tests a new combination therapy for people with colorectal cancer who have minimal residual disease (MRD) — tiny amounts of cancer left after treatment. The approach uses specially engineered immune cells from cord blood (TROP2-CAR-NK cells) plus a targeted…

This phase II trial tests whether adding cabozantinib to the immunotherapy drug nivolumab can prevent mucosal melanoma from returning after surgery. About 101 patients with resected mucosal melanoma will receive either nivolumab alone or nivolumab plus cabozantinib. The study aim…

This study compares two approved drugs, risankizumab and vedolizumab, in about 530 adults with moderate to severe ulcerative colitis who have not tried targeted therapies before. Participants will receive one of the two drugs for about a year. The main goal is to see which drug b…

This phase III trial tests whether adding the immunotherapy drug nivolumab after standard combined modality therapy (chemo and radiation) can improve outcomes for patients with high-risk stage IIB-IIIC anal cancer. About 344 participants will receive nivolumab or a placebo. The m…

This study tests whether giving two immunotherapy drugs (nivolumab and ipilimumab) along with a short course of radiation can completely eliminate advanced rectal cancer before surgery. About 31 adults with a specific genetic type (MSI-H/dMMR) of stage II or III rectal cancer wil…

This early-phase trial is testing whether adding an experimental drug called ZEN003694 to two approved cancer drugs (cetuximab and encorafenib) can help patients with a specific type of advanced colorectal cancer that has not responded to prior treatments. The study involves 30 a…

This study is testing three long-acting antibodies, alone or in combination, in 645 people with ulcerative colitis. The goal is to see if they are safe and can improve bowel inflammation over 48 weeks. Participants are joining from a previous study and may have already seen some …

This trial is testing whether a combination of chemotherapy drugs (liposomal irinotecan and capecitabine) plus radiation, given before surgery, can help people with locally advanced rectal cancer. The treatment plan is personalized based on a genetic marker (UGT1A1) that affects …

This trial is testing whether combining two standard drugs—fruquintinib and TAS-102—can help people with metastatic colorectal cancer that has stopped responding to at least two prior chemotherapy regimens. The study will measure how long patients live without the disease getting…

This study tests an oral medication called tofacitinib in children aged 2 to 17 with moderate to severe ulcerative colitis, a chronic bowel disease causing inflammation and bleeding. The goal is to see if the drug can bring the disease into remission (no symptoms and healed gut l…

This trial is testing whether a more focused radiation field, combined with chemotherapy and an immunotherapy drug called camrelizumab, can improve outcomes for people with a certain type of locally advanced rectal cancer. The study will compare this new approach to a standard tr…

This phase 2 trial tests whether combining two immunotherapy drugs (durvalumab and tremelimumab) with or without radiation therapy can shrink tumors in people with metastatic colorectal or non-small cell lung cancer. About 110 participants will receive the drugs alone or with hig…

This study tests whether adding two targeted drugs (encorafenib and cetuximab) to standard immunotherapy (pembrolizumab) works better than immunotherapy alone for people with a specific genetic type of advanced colorectal cancer. About 107 participants with untreated, metastatic …

This study tests two immunotherapy drugs, nivolumab and ipilimumab, in people with anal cancer that has spread and not responded to prior treatment. The goal is to see if these drugs can shrink tumors or slow cancer growth. About 143 adults with advanced squamous cell carcinoma o…

This trial explores whether stem cells taken from a patient's own bone marrow during surgery can help treat fistulas—abnormal tunnels under the skin—caused by Crohn's disease. The stem cells are prepared quickly in the operating room and injected into the fistula tract. Researche…

This early-phase trial is testing a new way of giving radiation therapy (ultra-fractionated, short course) along with standard chemotherapy for people with locally advanced rectal cancer. The goal is to see if this combination can shrink the tumor enough to avoid surgery. The stu…

This phase 3 trial tests whether a new targeted drug (MRTX849) combined with cetuximab works better than standard chemotherapy for people with advanced colorectal cancer that has a specific KRAS G12C mutation. About 461 participants whose cancer worsened after first-line treatmen…

This early-stage study tests an oral drug called LY3410738 in people with advanced solid tumors (like bile duct cancer, cartilage cancer, or brain tumors) that have specific IDH1 or IDH2 mutations. The main goal is to find a safe dose and see if the drug can shrink tumors. About …

This trial tests an experimental drug called ST316, alone or with other cancer drugs, in people with advanced solid tumors that have not responded to standard treatments. The study focuses on tumors that may have abnormalities in a cell signaling pathway called WNT/β-catenin. The…

This study tests a new drug, SX-682, alone and with the immunotherapy nivolumab, in people with a specific type of advanced colorectal cancer that has spread or cannot be removed. The cancer must have a RAS mutation and be microsatellite stable (MSS), which often makes it harder …

This study tests whether an experimental drug called D-2570 can help people with moderately to severely active ulcerative colitis achieve remission. About 120 adults will receive either D-2570 or a placebo daily for 12 weeks. The main goal is to see if more people on D-2570 reach…

This study tests whether transplanting a person's own fecal bacteria into the bowel before ileostomy reversal can improve bowel and anal function after rectal cancer surgery. Participants receive four weekly enemas made from their own stool. The goal is to reduce symptoms like le…

This study tests two drugs, panitumumab and trametinib, in people with stage IV colorectal cancer that no longer responds to standard treatments. The goal is to see if these drugs can shrink tumors or slow cancer growth. About 59 participants will receive either panitumumab alone…

This phase 3 trial tests whether adding bevacizumab (a drug that starves tumors by blocking new blood vessels) to standard maintenance chemotherapy helps people with metastatic colorectal cancer stay progression-free longer. About 400 adults whose disease is controlled after 4–6 …

This phase 2 trial studies whether combining chemotherapy with surgery to remove lung tumors works better than either treatment alone for patients with colorectal cancer that has spread only to the lungs. About 40 participants will be grouped by risk level to see if the combinati…

This phase 2 trial is testing whether a combination of four drugs—BMS-986340, nivolumab, trifluridine/tipiracil, and bevacizumab—can help control advanced colorectal cancer that has not responded to standard treatments. The study is for people with a specific type called microsat…

This trial compares changing the dressing on a PICC line (a type of central catheter) every week versus every two weeks in people with colon or pancreas cancer receiving chemotherapy. The goal is to see if less frequent changes are just as safe, with no increase in skin injuries,…

This trial tests a new drug called BAY 1895344 (elimusertib) combined with standard chemotherapy (FOLFIRI) in people with advanced or metastatic stomach or colorectal cancer. The goal is to find the safest dose and see if the combination can shrink tumors. Participants receive th…

This phase 1 trial tests a new method of delivering chemotherapy for people with cancers that have spread to the lining of the abdomen (peritoneal carcinomatosis) from gastrointestinal cancers like colorectal, stomach, or pancreatic cancer. The drug, nanoliposomal irinotecan (Oni…

This trial investigates whether combining two drugs—galunisertib and capecitabine—can help people with advanced colorectal cancer that has spread to the lining of the abdomen (peritoneal metastases) and no longer responds to standard chemotherapy. The study has two parts: first, …

This trial tests a digital tool that helps doctors and patients manage cancer risks linked to hereditary syndromes like BRCA-related breast/ovarian cancer and Lynch syndrome. The tool provides personalized recommendations during primary care visits. Researchers compare care gaps,…

This study tests a therapy called CEA CAR-T, which uses a patient's own immune cells modified to recognize and attack cancer cells that carry a protein called CEA. It is for adults aged 18-75 with advanced or recurrent solid tumors (such as lung, colorectal, liver, pancreatic, ga…

This early-phase trial tests an experimental immunotherapy called ELI-002 7P in people with pancreatic or other solid tumors that have specific KRAS or NRAS gene mutations. The treatment aims to train the immune system to attack cancer cells. About 158 participants will receive t…

This trial tests whether giving chemotherapy before or after radiation therapy works better for people with locally advanced rectal cancer that has a high risk of coming back. Participants receive the same drugs (capecitabine and oxaliplatin) but in a different order. The goal is…

This phase 2 trial tests whether a modified virus (VV1) combined with the immunotherapy drug cemiplimab can shrink tumors in people with colorectal cancer, head and neck squamous cell carcinoma, or melanoma that has stopped responding to checkpoint inhibitor treatment. The virus …

This phase 2 trial is testing whether adding two drugs—a PCSK9 inhibitor and a PD-1 inhibitor—to standard chemoradiotherapy can help shrink tumors in patients with locally advanced rectal cancer that has a specific genetic profile (pMMR/MSS). The study involves 30 participants an…

This study tests whether adding an immunotherapy drug (tislelizumab) to standard chemoradiation before surgery can improve outcomes for people with locally advanced rectal cancer. About 100 participants will receive the combination treatment, and researchers will measure how many…

This study tests whether adding two drugs—adebrelimab (an immunotherapy) and apatinib (a targeted therapy)—to standard chemoradiotherapy before surgery can improve outcomes for people with locally advanced or low-lying rectal cancer. The goal is to shrink the tumor enough to allo…

This clinical trial is testing whether combining two drugs—capecitabine (a chemotherapy pill) and lenvatinib (a targeted therapy)—can shrink tumors in people with advanced colorectal cancer that has stopped responding to standard treatments. The study enrolls adults aged 19 and o…

This study tests whether adding two targeted drugs (encorafenib and cetuximab) after standard surgery and chemotherapy can lower the chance of cancer coming back in people with a specific genetic type of stage II/III colon cancer (BRAF V600E). Participants either receive the drug…

This Phase 2 trial tests a combination of pembrolizumab (Keytruda) and quavonlimab against other drug combos in 302 people with stage IV colorectal cancer that has a specific genetic feature (MSI-H or dMMR). The goal is to see if the new combo shrinks tumors better and for longer…

This study tests a new drug called ARV-806 in adults with advanced solid tumors that have a specific KRAS G12D mutation. The drug aims to break down the mutated protein that helps tumors grow. The trial has two parts: first, finding a safe dose in small groups, then testing that …

This study tests a combination of two oral drugs, D-1553 and IN10018, in people with advanced solid tumors that have a specific genetic change called KRAS G12C. The goal is to find the best dose and see if the combination can shrink tumors or slow their growth. About 140 adults w…

This Phase III trial tests whether a modified short-course radiation that spares nearby lymph nodes, combined with chemotherapy (CAPOX) and the immunotherapy drug tislelizumab, works better than standard radiation plus chemotherapy for people with a certain type of rectal cancer …

This study compares a standard seton (a thread used to drain and heal fistulas) with one coated in Glubran, a surgical glue with antimicrobial and healing properties. The trial includes adults with high or complex anal fistulas, a painful condition that can cause infection and in…

This trial compares two surgical techniques for women with full-thickness rectal prolapse: a modified rectosacrouteropexy and the standard Wells rectopexy. The goal is to see which method leads to fewer recurrences, fewer complications, and better pelvic floor function. Thirty-si…

This trial investigates whether less invasive treatments can save the rectum in people with early-stage rectal cancer. Participants receive either standard surgery (removing part of the rectum) or one of two organ-sparing approaches: short-course radiotherapy or chemoradiation (c…

This study tests a combination of two drugs, neratinib and valproate, in people with advanced solid tumors that have not responded to standard treatments. The first part finds the safest dose, and the second part focuses on cancers with a RAS mutation, like certain colon and panc…

This phase II trial is testing whether adding an experimental immunotherapy drug (retlirafusp alfa) to short-course radiation and standard chemotherapy can completely eliminate locally advanced rectal cancer before surgery. The study plans to enroll 44 adults aged 18-70 with stag…

This study tests whether following the Norwegian dietary guidelines—including healthy foods, cooking classes, and physical activity—can improve survival and reduce cancer recurrence in 503 people who had colorectal cancer. Participants are guided by nutritionists and given food d…

This trial tests a new drug called Cadonilimab in 28 people with advanced colorectal cancer that has not responded to standard immunotherapy. The drug is a bispecific antibody that targets two immune checkpoints (PD-1 and CTLA-4) to potentially reactivate the immune system agains…

This trial tests an experimental drug called TRK-950 in combination with several standard anti-cancer treatments for people with advanced solid tumors, including colorectal, bladder, ovarian, and other cancers. The main goal is to find safe doses and understand side effects. Part…

This trial investigates whether using a special dye called indocyanine green (ICG) during surgery helps improve outcomes for people with stage III colorectal cancer. The dye makes lymph nodes and cancer tissue glow under a special camera, helping surgeons see and remove more of t…

This phase 2 trial is testing a combination of three drugs—ATRA (a vitamin A derivative), bevacizumab (a blood vessel growth blocker), and atezolizumab (an immunotherapy)—in 22 people with advanced colorectal cancer that has not responded to prior treatments. The goal is to see i…

This study tests two immunotherapy drugs, durvalumab and monalizumab, in about 383 adults with advanced solid tumors, including colorectal cancer. The goal is to see if the combination is safe and can shrink tumors. Some participants also receive standard chemotherapy or other ta…

This study tests a drug called mirvetuximab soravtansine in Japanese patients with advanced ovarian cancer or other solid tumors that have a specific protein (folate receptor alpha). The drug is designed to target and kill cancer cells while sparing healthy ones. The trial has tw…

This study tests two drugs—regorafenib (a chemotherapy pill) and pembrolizumab (an immunotherapy)—in people with metastatic colorectal cancer who have already tried several other treatments. The goal is to see if the combination is safe and can slow tumor growth. About 73 partici…

This phase 2 trial tests whether adding an experimental drug called onvansertib to standard chemotherapy and bevacizumab can shrink tumors better than chemo alone in people with advanced colorectal cancer that has a KRAS or NRAS mutation. About 110 participants who have not had p…

This study tests whether giving vedolizumab every 4 weeks instead of every 8 weeks can help Japanese patients with moderate to severe ulcerative colitis or Crohn's disease whose symptoms returned during standard treatment. About 56 participants will receive the drug intravenously…

This phase 3 trial tests whether taking a low-dose aspirin (100 mg) daily for three years can prevent colon cancer from coming back after surgery. It includes 264 people with stage II or III colon cancer who have a specific mutation in the PI3K gene. Participants are randomly ass…

This study tests whether a combination of two targeted drugs (encorafenib and cetuximab), given alone or with chemotherapy, works better than standard chemotherapy for people with a specific genetic form of advanced colorectal cancer (BRAF V600E mutation) that has spread and hasn…

This study tests whether combining two immunotherapy drugs (nivolumab and ipilimumab) with radiation therapy can control or shrink tumors in people with colorectal or pancreatic cancer that has specific genetic features (MSS or MSI-high). About 84 adults with advanced disease are…

This study is testing whether a short-term, low-calorie diet called a fasting mimicking diet (FMD) can help patients recover better after surgery for colorectal cancer. The diet is given in cycles after the operation and is designed to be easier to follow than complete fasting. R…

This study looks at whether taking a common ulcerative colitis medication (5-ASA) at a specific time of day—morning or evening—can better reduce hidden inflammation. Thirty-two adults with inactive UC will try both timing schedules over three months. Researchers will measure infl…

This early-phase study tests a new oral drug called E7386 in about 60 adults with advanced solid tumors (like desmoid tumors) that have not responded to other treatments. The main goals are to find the safest dose and check for side effects. Researchers will also watch for any tu…

This study tests whether a combination of chemotherapy (FOLFOX) and a short course of radiation can eliminate advanced rectal cancer without needing surgery. 12 adults with locally advanced rectal cancer are being watched closely after treatment to see if the cancer fully respond…

This phase 2 trial tests two drugs, regorafenib and lorigerlimab, in people with high-risk colorectal cancer who have no visible tumors but still have cancer DNA in their blood after standard treatment. The goal is to see if the combination can clear these hidden cancer cells and…

This phase 2 study tests a personalized immune cell therapy called tumor-infiltrating lymphocytes (TIL) in 20 people with advanced solid cancers (like stomach, colon, or pancreatic cancer) that have not responded to standard treatments. Patients first receive chemotherapy to prep…

This study looks at how well a new robotic surgical system works for removing colon or rectal tumors. About 60 adults who need surgery for benign or malignant colorectal conditions will take part. The goal is to see if the system is safe and can complete the surgery without switc…

This phase II trial tests whether delivering chemotherapy directly into the liver (hepatic arterial infusion) along with standard IV chemo can shrink inoperable liver tumors from colorectal cancer enough to allow surgical removal. The study involves 64 participants whose cancer h…

This study tests four different tools—coaching, education, text messages, and health coaching—to help cancer survivors improve their diet, physical activity, and weight. About 350 adults who have completed treatment for several cancer types will use these tools for up to 48 weeks…

This study tests whether giving two immunotherapy drugs (IBI310 and sintilimab) before surgery can eliminate or shrink tumors in people with a specific genetic type of colon cancer (MSI-H/dMMR). About 453 adults with stage IIB or III colon cancer that can be surgically removed wi…

This early phase trial tests a biological product mix designed to train the immune system to recognize and kill CEA-positive rectal cancer cells. The study involves 20 participants with early-stage rectal cancer (Stage 0 to IIA) who have not yet developed symptoms or metastasis. …

This phase 3 trial tests two different doses of an investigational drug called telisotuzumab adizutecan in about 74 adults with metastatic colorectal cancer that has stopped responding to standard treatments and whose tumors have a specific protein (c-Met). The drug is given by I…

This study tests a more intense chemotherapy regimen (mFOLFOXIRI) plus the drug bevacizumab against a standard regimen (mFOLFOX-6) plus bevacizumab as a first treatment for people with advanced colorectal cancer that cannot be removed by surgery. The trial includes 528 participan…

This study looks at whether giving chemotherapy both before and after surgery (perioperative) is better than only after surgery for people with advanced colon cancer. About 738 participants will be randomly assigned to one of two groups. The goal is to see if the perioperative ap…

This phase 2 pilot study is testing whether giving two immunotherapy drugs, botensilimab and balstilimab, before surgery can shrink tumors in people with colorectal cancer. The trial includes 26 participants across three groups, with some receiving more doses and one group having…

This study looks at the long-term safety of filgotinib, a drug for ulcerative colitis, in over 1,100 adults who already took part in a filgotinib trial. The main goal is to track side effects and lab test changes over time. Participants must have completed a prior filgotinib stud…

This study tests a treatment plan to avoid major surgery for early-stage rectal cancer. Patients first receive chemotherapy, then a small surgery to remove the tumor, followed by radiation and more chemo. The goal is to see if this approach can cure the cancer while keeping the r…

This study tests whether combining two drugs (nivolumab and regorafenib) with short-course radiation can shrink tumors in people with stage II or III rectal cancer. About 72 participants will receive the drugs before and after radiation, followed by surgery or a watch-and-wait ap…

This early-stage trial is testing a combination of pelareorep (a reovirus) and atezolizumab (an immunotherapy) along with standard chemotherapies in people with advanced anal or pancreatic cancers. The study aims to find safe doses, look for biomarkers that predict response, and …

This phase 2 trial is testing two different sequences of the drugs panitumumab and regorafenib in 214 patients with advanced colorectal cancer that no longer responds to standard treatments. The goal is to see which order of these drugs helps patients live longer. Participants mu…

This study tests a new drug called BMX-001 added to standard radiation and chemotherapy for people newly diagnosed with anal cancer. The goal is to see if BMX-001 can reduce severe side effects like rectal bleeding and skin problems while still fighting the cancer. About 24 adult…

This study tests a new immunotherapy drug, HX008, against standard chemotherapy for people with a specific type of advanced colorectal cancer (MSI-H/dMMR). The goal is to see if HX008 can delay cancer growth better than chemotherapy. About 190 adults with this genetic marker will…

This early-phase study tests a new drug called RMC-6291 in adults with advanced cancers (lung, colon, pancreatic) that have a specific KRAS G12C mutation. The goal is to find the safest dose and see how well the drug works. About 222 participants will receive the drug by mouth, a…

This study tests whether giving a single dose of radiation directly to the tumor area during surgery is feasible for people with advanced or recurrent rectal cancer. About 31 participants will be randomly assigned to receive standard surgery, surgery plus a standard radiation dos…

This study tests two drug combinations for people with advanced colorectal cancer that has a specific genetic change called KRAS G12C. In one group, patients who haven't had treatment yet will receive the drugs IBI351 and cetuximab β plus chemotherapy (FOLFIRI). In another group,…

This early-phase study tests an investigational drug called telisotuzumab adizutecan in about 30 Chinese adults with advanced colorectal cancer that cannot be removed by surgery. The main goals are to check safety and how the drug moves through the body. Participants receive diff…

This trial is for people with colorectal cancer that has spread to a few spots in the body but cannot be fully removed by surgery alone. After 3-4 months of standard chemotherapy, participants either continue chemotherapy alone or also receive local ablative therapy—such as surge…

This early-phase study tests a new treatment called WD-01, which uses a patient's own immune cells modified to target a protein (GCC) found on colorectal cancer cells. The goal is to see if it is safe and can shrink tumors in people with metastatic colorectal cancer who have alre…

This early-phase trial tests a new universal CAR-T cell therapy (REVO-UWD-01) in 30 adults with metastatic colorectal cancer that has spread. The treatment targets a protein called GCC found on cancer cells. The main goals are to find the safest dose and check for side effects, w…

This study tests whether a gel made from a patient's own blood (platelet-rich plasma) can help close perianal fistulas—abnormal tunnels that form near the anus. One hundred adults with this condition will receive the gel during a procedure, and doctors will check if the fistula h…

This study looks at whether using just one medication (infliximab) under the skin works as well as using it together with another immune-suppressing drug for people with Crohn's disease or ulcerative colitis. About 420 adults who have already started infliximab will be followed f…

This phase 3 trial compares two treatment approaches for high-risk rectal cancer. The experimental group gets a short course of radiation (5 days) followed by several months of chemotherapy before surgery. The standard group receives longer chemoradiotherapy followed by surgery a…

This early-stage trial tests a new drug called ALTB-268, a monoclonal antibody, in 24 healthy volunteers. The main goal is to check safety and how the body processes the drug. If it passes safety checks, it may later be tested in people with ulcerative colitis to see if it can co…

This study tests whether giving a higher, targeted radiation dose to the main tumor and nearby lymph nodes can improve outcomes for people with locally advanced rectal cancer. About 128 adults whose cancer has not spread beyond the pelvis will receive either standard radiation or…

This trial tests a nurse-led health program for women aged 45 to 64 in Hong Kong. The program uses a 5-step approach (ask, advice, assess, assist, arrange) to help women manage conditions like high blood pressure, anxiety, and menopause symptoms. Researchers will compare the prog…

This study tests a temporary device called Colovac that is placed inside the bowel after colon cancer surgery to protect the surgical connection. The goal is to see if it can help patients avoid needing a temporary stoma bag. About 108 adults with colon cancer will take part, and…

This study tests whether a bioelectric wound dressing can reduce infections after colon surgery better than the usual antiseptic skin prep. About 20 adults having elective colon surgery will be enrolled. Researchers will measure bacteria levels in skin samples to compare the two …

This study compares a newer, less invasive surgery (reduced-port laparoscopy) to standard laparoscopic surgery for people with colon or upper rectal cancer. The goal is to see if the newer approach is as safe and effective, while possibly causing less pain and faster recovery. 50…

This early-phase trial tests whether adding a personalized immune treatment to standard chemotherapy can prevent cancer recurrence in colorectal cancer patients who have minimal residual disease (MRD) after surgery. Ten adults aged 18-80 with stage II (high-risk) or stage III col…

This study tests whether adding high-dose vitamin D3 to standard anti-TNF therapy can improve symptoms and reduce inflammation in people with active Crohn's disease or ulcerative colitis. About 100 adults starting anti-TNF treatment will receive either vitamin D3 or a placebo for…

This pilot study tests a new rectal applicator for delivering radiation therapy to elderly patients with inoperable rectal cancer. The treatment combines external beam radiation with three sessions of internal radiation (brachytherapy) using the new device. The study aims to see …

This study tests a support program for teens aged 16-17.5 with Crohn's disease or ulcerative colitis as they move from pediatric to adult healthcare. The program includes personalized assessments, a transition navigator, and virtual skill-building sessions. Researchers will measu…

This study tests a low dose of the immunotherapy drug nivolumab, alone or with chemotherapy, in people with advanced colorectal or stomach cancers that have a specific genetic feature (MSI/dMMR). The goal is to see if this approach can shrink tumors before surgery or control the …

This study looks at whether the probiotic VSL#3 can change how bile acids work in people with Crohn's disease or ulcerative colitis. About 79 participants will take two sachets of VSL#3 daily for six weeks. Researchers will measure bile acid levels in blood and stool to see if th…

This study tests a new robotic surgery method for removing rectal tumors. The approach uses a single-port robot to improve flexibility and visibility during the operation. Researchers will study 20 patients with benign or early-stage rectal tumors to see if the procedure is safe …

This phase 2 trial is testing whether low doses of the immunotherapy drugs nivolumab or pembrolizumab can shrink tumors in people with a specific genetic type of colorectal cancer (MSI/dMMR) before they have surgery. The study involves 30 participants with stage II-III disease wh…

This study aimed to test whether injecting stem cells from a donor's bone marrow into the pouch (a surgically created internal reservoir) could safely treat pouchitis that hadn't improved with antibiotics or other drugs. The trial was planned for 12 adults aged 18-75 in the U.S.,…

This study looks at how well a combination of three drugs—capecitabine, oxaliplatin, and bevacizumab—works as a first treatment for elderly patients (70 and older) with metastatic colorectal cancer that cannot be removed by surgery. The goal is to see if this approach can delay c…

This study tests whether a fecal transplant (FMT) can safely and effectively treat recurrent C. difficile infections in children, including those with inflammatory bowel disease (IBD). Researchers will give FMT to 250 children aged 3-21 and track whether the infection comes back.…

This study aimed to test whether injecting donor stem cells directly into fistulas could safely help heal them in people with Crohn's disease who have an ileal pouch. The trial was withdrawn before any participants were enrolled, so no results are available. The approach was expe…

This study tests a new surgical technique called transanal total mesorectal excision (taTME) for rectal cancer. Instead of operating from the abdomen, surgeons work from the anus upward, which may make it easier to remove the tumor completely. The trial includes 100 adults with e…

This early-phase study tests whether adding Akkermansia probiotics to standard immunotherapy and chemotherapy can safely help patients with advanced colorectal cancer that hasn't responded to prior treatments. The trial enrolls 22 adults whose tumors are MSS/pMMR type, which typi…

This phase 2 trial tests whether adding the experimental drug galunisertib to standard chemoradiation can improve outcomes for people with locally advanced rectal cancer. About 50 participants will receive the combination over 8 weeks, followed by surgery. Researchers will also s…

This study tests whether giving either short-course radiation or long-course chemoradiation, followed by a strong chemotherapy cocktail (mFOLFOXIRI), can shrink low rectal tumors enough to avoid radical surgery. About 66 adults with stage T2-4a rectal cancer whose tumor is within…

This early-phase trial tests a new drug called AI-061, which combines two immune-boosting antibodies (anti-PD-1 and anti-CTLA-4) into one treatment. The study will enroll 18 adults with advanced solid tumors that have spread or cannot be removed. The main goals are to find a safe…

This study tests a new treatment approach for people with advanced colorectal cancer that has spread to the liver, lungs, or abdomen and cannot be removed with surgery. The treatment combines a short course of radiation with immunotherapy (tislelizumab), chemotherapy (CAPOX), and…

This was a phase 2 study planned to test a new drug called NGM707 combined with the immunotherapy pembrolizumab in people with advanced or metastatic solid tumors, specifically colorectal cancer. The goal was to see if the combination could shrink tumors and to check for side eff…

This phase II trial tests whether adding tocotrienol, a form of vitamin E, to standard chemotherapy and bevacizumab can improve treatment and reduce side effects in people with metastatic colorectal cancer. About 83 participants will be randomly assigned to receive either tocotri…

This study tests a new drug called Hemay005 for people with moderate to severe ulcerative colitis, a chronic gut condition. About 92 participants will receive either a low dose, high dose, or a placebo for 12 weeks. The goal is to see if the drug can reduce symptoms like diarrhea…

This study tests a new drug called 9-ING-41, given alone or with chemotherapy, in adults with cancers that have not responded to standard treatments. The goal is to see if the drug is safe and can help control the disease. About 350 people with various advanced cancers, including…

This early-phase study tests two experimental immunotherapy drugs — botensilimab and balstilimab — alone and together in people with advanced solid tumors that have stopped responding to standard treatments. The main goals are to check safety, find the right dose, and look for ea…

This phase 2 trial is testing a combination of two drugs, cabozantinib and nivolumab, in 48 people with advanced colorectal cancer that has not responded to standard treatments. The goal is to see if the combination can shrink or stabilize tumors. All participants have a type of …

This study tests whether giving a probiotic called Lactobacillus plantarum after surgery for a burst appendix can reduce inflammation, pain, and hospital stay. Researchers will measure white blood cell counts and pain levels in 50 adults. The goal is to see if probiotics help con…

This study is observing 300 adults with metastatic colorectal cancer who are receiving a combination of two drugs (fluoropyrimidine and bevacizumab). The goal is to measure how long patients live and how long the cancer stays under control. The study is not testing a new treatmen…

This early-stage trial tests a personalized cell therapy for people with advanced colorectal, pancreatic, or lung cancers that have a specific KRAS G12V mutation. The treatment involves taking a patient's own immune T cells, engineering them to recognize and attack cancer cells, …

This early-phase study tests a new drug called ERAS-601, alone or with other cancer treatments, in adults with advanced solid tumors that have not responded to standard therapies. The main goals are to find safe doses and check for side effects. About 90 participants will take pa…

This study tests a combination of three drugs—fruquintinib, an immunotherapy, and an oral chemo—in people with advanced colorectal cancer that has stopped responding to standard treatments. The goal is to see if this mix can shrink tumors and extend life. About 106 participants w…

This study tests whether giving chemotherapy before and after surgery (plus heated chemo directly into the abdomen) helps people with colorectal cancer that has spread to the lining of the abdomen live longer. About 358 adults with resectable disease are randomly assigned to eith…

This study tests a new drug called JDQ443, alone or with other treatments, for people with advanced solid tumors that have a specific genetic change called KRAS G12C. The goal is to find the safest dose and see if the drug can shrink tumors. About 344 adults whose cancer has not …

This study tests an oral enzyme called SYN-004 in adults who have received a stem cell transplant and need intravenous antibiotics for fever. The enzyme is designed to break down antibiotics in the gut, protecting the natural bacteria there. Researchers will check safety, whether…

This study compares two minimally invasive treatments—microwave ablation and stereotactic body radiation therapy—for colorectal cancer that has spread to the liver. About 100 patients with 1 to 3 liver tumors that cannot be surgically removed will be randomly assigned to one of t…

This study tests a new drug (JAB-21822) combined with cetuximab in people with advanced colorectal, small intestine, or appendiceal cancers that have a specific KRAS G12C mutation. Participants must have already tried at least one standard treatment. The goal is to see if the com…

This early-stage study tests the safety of tucatinib in about 25 Chinese patients with advanced HER2+ breast, stomach, or colorectal cancer that has worsened after standard treatments. Researchers will monitor side effects and how the drug moves through the body. The goal is to s…

This study tests whether low-dose aspirin can help prevent colorectal cancer from coming back in patients whose tumors have certain genetic changes (in the PI3K pathway). Over 600 patients who had surgery for stage II or III colon or rectal cancer are randomly assigned to take as…

This study planned to test two drugs, regorafenib and lorigerlimab, given before surgery to people with colorectal cancer that had spread only to their lungs. The goal was to see if the combination was safe and could help shrink tumors. However, the trial was withdrawn before any…

This Phase I trial tests a combination of two oral drugs, defactinib and VS-6766, in people with advanced solid tumors such as non-small cell lung cancer, low-grade serous ovarian cancer, and pancreatic cancer. The study aims to find the safest dose and evaluate how well the drug…

This study compares giving 3 rounds of chemotherapy before surgery versus the standard approach of surgery followed by 8 rounds of chemo for people with locally advanced colon cancer. The goal is to see if the pre-surgery chemo works just as well and may allow some patients to sk…

This study tests two immunotherapy drugs, AK119 and AK112, alone or with chemotherapy, in 170 people with a common type of colorectal cancer (pMMR/MSS). The goal is to see if these combinations shrink tumors and are safe. The trial is active but not recruiting new participants.

This study tests whether using a computer dashboard to guide infliximab dosing is more effective and safer than standard dosing for people with Crohn's disease or ulcerative colitis. About 124 participants will receive either dashboard-guided or standard treatment, with the goal …

This phase III trial tests whether adding high-dose vitamin D3 to standard chemotherapy and bevacizumab helps people with metastatic colorectal cancer. About 455 patients who have not had prior treatment for their advanced disease are taking part. The goal is to see if the vitami…

This early-phase study tests a new drug called E7386 in about 70 people with advanced solid tumors, including colorectal cancer. The main goal is to check safety and find the right dose. Participants have tumors that no longer respond to standard treatments.

This Phase 3 trial tests whether a short course of radiotherapy followed by the immunotherapy drug camrelizumab plus chemotherapy works better than standard long-term chemoradiation for locally advanced rectal cancer. About 230 patients will be randomly assigned to one of the two…

This early-stage trial is testing whether a combination of two drugs, naporafenib and trametinib, can shrink or control advanced solid tumors that have a specific genetic change called RAS Q61X. About 86 people whose cancer has not responded to standard treatments will receive th…

This study looks at whether closing the pelvic floor with stitches after removing rectal cancer can stop the bowel from getting blocked. About 516 people having keyhole surgery for mid-low rectal cancer will be randomly assigned to get the closure or not. The main goal is to see …

This study tests whether a drug called QBECO, given as a self-injection before and after liver surgery, can lower the chance of colorectal cancer coming back or spreading. About 115 adults with colorectal cancer that has spread to the liver will take part. They will inject the dr…

This study looks at whether a 6-month exercise program (a mix of aerobic and resistance training) can improve fitness and reduce the risk of cancer coming back in patients who had surgery for colorectal cancer that spread to the liver. About 66 participants will be split into thr…

This study tests a digital health system that reminds people with inflammatory bowel disease (IBD) to take their medication and lets them report symptoms. About 123 adults starting a new oral or injectable treatment will use the system or get standard care for 12 months. The goal…

This Phase 2 trial tests a combination of three drugs—Tislelizumab, Fruquintinib, and Metronidazole—in 33 adults with advanced colorectal cancer that has not responded to earlier treatments. The goal is to see if this mix can slow cancer growth and improve survival. Participants …

This study compares two ways of preparing the bowel before left-sided colorectal cancer surgery: standard mechanical bowel prep alone versus mechanical prep plus oral antibiotics (rifaximin and metronidazole). The goal is to see if adding antibiotics reduces surgical site infecti…

This study tests a new way for cancer doctors and primary care doctors to work together to help cancer survivors manage other health problems like high blood pressure, diabetes, and high cholesterol. About 800 adults with certain cancers and at least one of these conditions will …

This phase 3 trial tests whether adding the immunotherapy drug sintilimab to standard chemotherapy and bevacizumab helps people with a specific type of advanced colorectal cancer (RAS-mutant, MSS) live longer without their cancer growing. About 446 adults who have not had prior t…

This early-phase study tests an experimental drug called MCLA-129, a bispecific antibody that targets two cancer-related proteins (EGFR and c-MET). It is for people with advanced non-small cell lung cancer, gastric cancer, esophageal cancer, head and neck cancer, or colorectal ca…

This study tests an experimental drug called AZD5305, a PARP inhibitor, either alone or combined with other cancer drugs in people with advanced solid tumors (like ovarian, breast, pancreatic, and lung cancers). The goal is to see if the treatment is safe and can shrink tumors. A…

This phase II study aimed to test two immunotherapy drugs (tiragolumab and atezolizumab) combined with targeted radiation in people with microsatellite stable (MSS) metastatic colorectal cancer, a type that typically doesn't respond to immunotherapy. The trial was withdrawn befor…

This pilot study aimed to see if adjusting the dose of the chemotherapy drug 5-FU based on its concentration in the blood could improve treatment for metastatic colorectal cancer. The study was withdrawn before enrolling any participants. It was designed for adults with metastati…

This study looks at whether starting chemotherapy 10 to 14 days after surgery for stage III colon cancer is better than waiting the usual 2 weeks or more. About 300 patients are taking part to see if earlier treatment improves survival and lowers the chance of cancer coming back.…

This study tests a new robotic tool called the EndoR Surgical System for removing early-stage colorectal lesions. The goal is to see if it can make the procedure safer and more effective than current methods. Six adults aged 18 to 85 with superficial colorectal lesions will take …

This study compares two treatments for colorectal cancer that has spread to the liver: surgical removal of tumors versus a less invasive needle ablation procedure guided by 3D imaging. 230 patients are randomly assigned to one of the two treatments. The goal is to see if ablation…

This Phase 2 trial tests a shorter course of radiation followed by FOLFOX chemotherapy before surgery for locally advanced rectal cancer. About 364 participants will be randomly assigned to either this new regimen or standard chemoradiation. The goal is to see if the shorter appr…

This study tests whether giving chemotherapy before surgery (instead of after) helps people with locally advanced colon cancer live longer without the cancer returning. About 708 adults aged 18 to 70 with non-spreading colon cancer are taking part. The goal is to see if early che…

This study aimed to see if adding the targeted drug inavolisib to standard chemotherapy and bevacizumab could help people with a specific genetic form of advanced colorectal cancer (PIK3CA-mutated). It was designed for adults who had not yet received treatment for metastatic dise…

This study looks at standardizing the surgical process for patients with advanced or recurrent rectal cancer that has spread to nearby organs. The procedure, called pelvic exenteration, removes the tumor along with affected structures. The goal is to improve teamwork among surgeo…

This study tests an experimental drug called WTX-330 in 100 adults with advanced solid tumors or non-Hodgkin lymphoma that have not responded to standard treatments. The trial has two parts: first, finding the safest dose and schedule, then expanding to see how well the drug work…

This study compares two ways of giving chemotherapy directly into the belly after surgery to remove visible cancer from the lining of the abdomen. The cancer comes from the appendix, colon, or rectum. About 292 adults will be randomly assigned to receive either early post-operati…

This study tests a combination of two drugs—TG4001 (a biologic that targets HPV) and avelumab (an immunotherapy)—in people with advanced HPV-16 cancers that cannot be removed by surgery or cured by radiation. The trial has two phases: first, to find a safe dose, and second, to se…

This small pilot study is testing two immunotherapy drugs, botensilimab and balstilimab, in 16 people with advanced colorectal cancer that has not spread to the liver. Participants receive the drugs in 6-week cycles, and if the cancer progresses, standard chemotherapy is added. T…

This study planned to test whether a living donor liver transplant, after standard chemotherapy, could help people with colorectal cancer that spread to the liver and could not be surgically removed. It aimed to enroll 25 donor-recipient pairs. However, the study was withdrawn be…

This study tests whether using a blood test for circulating tumor DNA (ctDNA) can help doctors decide if patients with stage II or III colon cancer need stronger chemotherapy after surgery. The trial compares standard chemo with a more intense regimen (FOLFOXIRI) and an additiona…

This study tests a two-year follow-up program for 200 adults with hereditary cancer syndromes like BRCA or Lynch syndrome. Participants get personalized care plans and regular check-ins with a genetics doctor to help them follow cancer prevention and screening guidelines. The goa…

This early-phase study tests an experimental oral drug (GSK4418959) in adults with advanced solid tumors that have specific genetic changes (dMMR or MSI-H). The drug works by blocking a protein (WRN) that these tumors need to survive. The study aims to see if the drug, alone or w…

This study tests a new drug called HCB101 given together with other cancer treatments for people with advanced solid tumors that have not responded well to prior therapy. About 500 adults will take part to find the safest dose and see if the combination can shrink tumors. The goa…

This study compares two types of robotic surgery for high rectal and sigmoid colon cancer: one that removes the tumor through the anus (NOSES-IV) and the traditional method. The goal is to see which approach leads to fewer complications, less pain, and a shorter hospital stay. Ab…

This Phase 3 trial tests whether adding anlotinib (a daily pill) to standard chemotherapy can help people with a certain type of advanced colorectal cancer live longer without the disease getting worse. About 748 participants with RAS/BRAF wild-type cancer that has spread will re…

This study tests a new approach for people with locally advanced rectal cancer that has a common genetic profile (MSS/pMMR). Instead of standard radiation before surgery, participants receive a combination of chemotherapy (mFOLFOX6) and an immunotherapy drug (PD-1 antibody). The …

This phase 1 trial tests a vaccine (p53MVA) that trains the immune system to attack cancer cells with a p53 mutation, given together with the immunotherapy drug pembrolizumab (Keytruda). The study includes 11 people with advanced solid tumors like lung, head and neck, liver, kidn…

This trial tests a modified stapling technique (MST) against the standard method in 450 adults having minimally invasive rectal cancer surgery. The goal is to see if MST reduces the chance of anastomotic leaks, a serious complication. Participants will be randomly assigned to one…

This pilot study tests whether a plant-based resistant starch, tailored to each child's gut bacteria, can improve gut health in 80 children with Crohn's disease or ulcerative colitis. Participants will take the starch or a placebo for a period, and researchers will measure change…

This study looks at whether using an antibiotic solution to wash the surgical area during laparoscopic appendix removal can lower the chance of wound infections in children with a burst appendix. About 200 children aged 18 or younger will take part. The goal is to find a better w…

This study tests whether a plant-based starch, tailored to each child's needs, can help restore a healthier gut microbiome in children with inflammatory bowel disease (Crohn's or colitis). About 100 children with mild disease or in remission will receive the starch for 6 months. …

This early-stage study tests whether delivering a patient's own stem cells directly into the artery that supplies the colon is safe for people with moderate to severe ulcerative colitis. Twenty adults who have not responded to at least two standard treatments will receive one dos…

This phase 2 trial tests Aquamin, a mineral supplement made from red marine algae, in 40 people with mild ulcerative colitis or those in remission. Researchers want to see if it improves symptoms, reduces inflammation, and helps maintain remission. Participants take 4 capsules da…

This phase II trial tests how well chemoradiation (using fluorouracil, leucovorin, and oxaliplatin) works before surgery for stage II or III rectal cancer. The study looks at different time intervals between chemoradiation and surgery to see which timing leads to the best tumor s…

This study tests whether adding extra stitches around the surgical connection in laparoscopic low rectal cancer surgery can reduce the risk of dangerous leaks. About 300 adults with low rectal cancer will be assigned to either standard surgery or surgery with reinforced stitching…

This study tests whether transplanting healthy donor stool into the gut can help people with ulcerative colitis, a chronic bowel disease. About 150 adults with active or steroid-dependent disease will receive either real fecal transplants or a sham procedure. The goal is to see i…

This study tests whether MitoQ, a supplement that protects cell batteries (mitochondria), can help people with moderate ulcerative colitis (UC) flare-ups. About 79 adults will take either MitoQ or a placebo daily for 24 weeks, alongside standard steroid treatment. The goal is to …

This early-stage trial tests a new drug called DECOY20, which is designed to wake up the immune system to fight cancer. It is being tested alone or with another drug (tislelizumab) in 120 adults with advanced solid tumors like liver, lung, or colorectal cancer. The main goals are…

This study compares two chemotherapy treatments, FOLFOX-6 and CAPOX, in 248 adults aged 20-70 with metastatic colorectal cancer that has spread after surgery. The goal is to see which regimen better controls the disease and causes fewer side effects like liver problems or severe …

This study tests whether adding a special bacterial strain (CMTS0515) to a standard fecal transplant can better relieve gut symptoms caused by radiation therapy for cancer. Sixty adults who completed radiation for abdominal or pelvic cancer will receive either the enhanced or sta…

This study tests a specially selected probiotic (LR607) in 300 people with mild-to-moderate ulcerative colitis, a form of inflammatory bowel disease. The probiotic is designed to boost a natural gut pathway (NOD2) that helps control inflammation. The goal is to see if adding LR60…

This study looks at whether a gluten-free diet can help people with primary sclerosing cholangitis (PSC) and inflammatory bowel disease (IBD). Researchers will track changes in symptoms, gut bacteria, and lab results in 60 adults over time. The goal is to see if avoiding gluten c…

This study tests whether giving a probiotic (Saccharomyces boulardii) along with a common antibiotic can protect the gut bacteria of children aged 4 to 12 being treated for ear or sinus infections. The goal is to see if it reduces antibiotic-associated diarrhea and limits the spr…

This study aimed to test whether MitoQ, a dietary supplement with antioxidant properties, could help control inflammation in children aged 6–17 with mild-to-moderate ulcerative colitis. Participants would have taken MitoQ or a placebo daily for 24 weeks alongside their usual medi…

This early-phase trial tests a new approach to treat advanced solid tumors by giving patients a large dose of their own immune cells that are specially selected to attack cancer. The cells are taken from the tumor, multiplied in the lab, and then infused back. Some patients also …

This study tests an oral drug called selpercatinib (LOXO-292) in children with advanced solid or brain tumors that have a specific RET gene change. The trial has two parts: first finding a safe dose, then measuring how many children's tumors shrink. About 36 children whose cancer…

This early-stage trial is testing a new drug called KFA115, either by itself or combined with the immunotherapy Keytruda (pembrolizumab), in 126 people with advanced cancers like lung, skin, kidney, and others. The main goal is to check safety and find the best dose. It is not ye…

This study is for people with a certain genetic type of advanced colorectal cancer (BRAF V600E) who previously benefited from a specific drug combination (encorafenib plus cetuximab). Researchers want to see if giving these drugs again, guided by a blood test that looks for cance…

This phase 2 trial tests whether adding the immunotherapy drug nivolumab (Opdivo) to standard chemoradiation and chemotherapy can improve outcomes for people with locally advanced rectal cancer. About 29 participants who have not had prior treatment will receive chemoradiation, t…

This phase 3 study tests whether a combination of trifluridine/tipiracil (a chemotherapy pill) and bevacizumab (a targeted therapy) works better than the current standard of capecitabine plus bevacizumab for people with metastatic colorectal cancer who are not healthy enough for …

This phase 2 trial is testing the immunotherapy drug pembrolizumab (Keytruda) in 25 adults with a specific type of advanced colorectal cancer (dMMR) that cannot be surgically removed. The goal is to see if the drug can shrink the tumors enough to make surgery possible. Treatment …

This study tests whether adding hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) to standard steroid drugs helps people with severe ulcerative colitis get better faster. About 44 adults with acute severe colitis will be randomly assigned to receive eithe…

This study compares different ways to collect anal cell samples and different HPV tests to see which combination best predicts high-grade anal dysplasia, a pre-cancerous condition. Researchers are enrolling men who have sex with men, including those with and without HIV. The goal…

This phase 1 trial is testing a new imaging tracer called 68Ga-FAPI-46 to see where it collects in normal and cancerous tissues. About 30 people with various solid tumors or blood cancers will receive the tracer and then undergo a PET/CT scan. The goal is to understand how the tr…

This early-phase trial tests a radioactive imaging agent called Technetium-99m HYNIC-FAPI in 15 people with metastatic lung, pancreas, breast, or colorectal cancer. The goal is to see how well it highlights tumors on SPECT/CT scans. Researchers will measure where the agent goes i…

This study is testing a new blood test called LUNAR-2 that looks for DNA from colorectal cancer in the bloodstream. It involves over 44,000 average-risk adults aged 45-84 who are already scheduled for a screening colonoscopy. The goal is to see how well this blood test can detect…

This study tests whether combining spectral CT scans with a genetic test (MSI) can more accurately predict if colorectal cancer has spread to nearby lymph nodes. Researchers will compare the imaging results with actual tissue samples from surgery or biopsy. The goal is to improve…

This study tests whether an artificial intelligence (AI) system can accurately identify the type of colon polyps during a colonoscopy, compared to standard visual inspection by the doctor. Over 1,700 adults having a colonoscopy will be randomly assigned to either AI-assisted or s…

This study looks at whether stool-based tests (like the FIT test and Cologuard) can accurately detect colorectal cancer and precancerous polyps in adults with cystic fibrosis. Researchers will compare these non-invasive tests to the standard colonoscopy in 350 participants. The g…

This study tests whether sending a colorectal cancer screening test directly to people's homes, without needing to order it first, increases the number of people who get screened. It involves 64,000 adults aged 50-74 in France. The goal is to see if this simple change leads to mo…

This study tests a computer program that analyzes colonoscopy images to help doctors decide if a growth (polyp) is an adenoma (pre-cancerous) or not. The software gives a probability score for each lesion. The trial involves 1,178 adults and compares the software's results to lab…

This study checks if a new stool test can better tell the difference between inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) compared to current tests. About 300 adults and teens will give a stool sample and have a colonoscopy as part of their regular care. If…

This study tests a new radioactive tracer called 18F-alphavbeta6-binding-peptide to see if it can safely and clearly show cancers in the breast, colon, lung, or pancreas. About 27 adults with these cancers will get the tracer and have a PET scan. The goal is to find out if this m…

This study looks at whether a blood test that detects tumor DNA can help decide which people with diverticulitis need a colonoscopy to check for colorectal cancer. Currently, almost everyone with diverticulitis is advised to get a colonoscopy, but many are unnecessary. The resear…

This study looks at whether CT scans can be used instead of colonoscopies to screen for colon cancer. Researchers will compare how well each method finds polyps and cancer in 600 adults aged 50-70. If CT scans work just as well, it could offer a faster and less invasive screening…

This study tests a special probe that checks blood flow in ulcers left after colon polyp removal. The goal is to see if using this probe to guide treatment can prevent delayed bleeding, especially in patients taking blood thinners or with large polyps. About 180 high-risk adults …

This study looks at whether taking aspirin in different patterns can help prevent colorectal cancer in people who have had colon polyps (adenomas). Aspirin may block certain enzymes that help cancer cells grow. The trial enrolled 81 adults with a history of colon polyps and measu…

This study tests whether sending text reminders to patients who are overdue for colorectal cancer screening helps them follow through and get a colonoscopy or stool test. About 3,888 adults with a scheduled primary care visit will take part. The goal is to make it easier for peop…

This study compares time-restricted eating (eating only between 12pm-8pm) to daily calorie restriction for weight loss and colorectal cancer risk reduction in 193 obese adults aged 45-70. Participants follow their assigned diet for 6 months, then a maintenance phase for another 6…

This study looks at whether taking low-dose aspirin can lower the risk of colorectal cancer in people who have already had precancerous polyps removed. Researchers measure changes in certain stem cell markers in the colon and other substances in the blood and urine. The goal is t…

This phase II trial tests whether riluzole, a drug used for ALS, can prevent nerve damage caused by oxaliplatin chemotherapy in people with stage II/III colorectal cancer. About 80 participants will receive either riluzole or a placebo during their chemo. The study is currently s…

This study tests whether a mobile health tool called mPATH™-Cloud can help more people get screened for colorectal cancer. Over 1,000 patients from a community health center in North Carolina who are overdue for screening will either receive usual care or get a link to the tool, …

This large pilot study in Norway is comparing two common colorectal cancer screening methods—flexible sigmoidoscopy (a one-time scope exam) and biennial fecal immunochemical testing (a stool test)—to see which works best for the general population. Over 140,000 men and women aged…

This large study is testing whether a screening procedure called flexible sigmoidoscopy can lower the number of colorectal cancer cases and deaths. About 100,000 men and women aged 50-64 in Norway are taking part. The study also looks at adding a stool blood test and how screenin…

This study tests whether taking two drugs, eflornithine and sulindac, together can lower the chance of new high-risk growths or a second colon cancer in people who have already had stage 0 to III colon or rectal cancer. About 350 participants who are cancer-free after surgery wil…

This study tests ways to help more people complete a colonoscopy after an abnormal stool-based colorectal cancer screening test. The researchers will use team-based best practices in clinics and a patient app with enhanced instructions and navigation. About 2,000 adults who speak…

This study tests whether wearing cold gloves during chemotherapy can prevent peripheral neuropathy (nerve damage causing numbness, tingling, or pain) in colon cancer patients. Forty adults with stage III colon cancer who are about to start a common chemo regimen (CAPOX) will be r…

This phase II/III trial tests whether duloxetine, a drug used for depression and pain, can prevent the nerve damage (pain, tingling, numbness) caused by oxaliplatin chemotherapy in stage II-III colorectal cancer patients. About 220 participants will receive either duloxetine or a…

This study tests a program called CARES-REACH that trains healthcare providers and uses electronic medical record tools to increase colorectal cancer screening rates in rural clinics. Researchers are working with 49 staff and providers from two healthcare systems. The goal is to …

This study tests whether a personalized exercise program, guided by video-based movement analysis, can help people with chemotherapy-induced peripheral neuropathy (CIPN) — a common side effect causing numbness, tingling, and balance problems. The trial enrolls adults with breast,…

This phase II trial tests whether time-restricted eating (intermittent fasting) can reduce side effects from radiation or chemoradiation in people with prostate, cervical, or rectal cancers. About 49 participants will either follow a time-restricted eating plan or receive standar…

This phase 2 study tests whether acupuncture can improve memory, focus, and thinking problems (often called 'chemo brain') in people who have had breast, colorectal, prostate, or gynecological cancer. About 48 participants will receive either real acupuncture or sham (fake) acupu…

This study tests the DISCO app, designed to help cancer patients talk with their doctors about treatment costs. About 254 adults newly diagnosed with breast, prostate, lung, or colorectal cancer will use the app to become more confident in asking cost-related questions. The goal …

This study tests a personalized self-management program to help cancer survivors on immune checkpoint inhibitors better handle side effects and reduce anxiety or depression. About 400 adults with breast, colon, lung, skin, or rectal cancer who recently started immunotherapy will …

This study tests whether a tailored exercise program and nutritional guidance can reduce peripheral neuropathy (nerve damage) and fatigue in people with colorectal cancer receiving chemotherapy. Participants follow a supervised exercise routine and monthly nutrition check-ins dur…

This pilot study investigates whether a liquid food product made from fermented mushroom extracts (AndoSanTM) can reduce fatigue in people who have had colorectal cancer. Participants with persistent moderate-to-severe fatigue will take the supplement for six weeks. Researchers w…

This trial tests whether removing the urinary catheter immediately after colorectal cancer surgery (before anesthesia wears off) is as safe and effective as removing it the next day. The goal is to lower the risk of urinary tract infections and help patients recover faster. About…

This trial tests whether watching an educational video before a surgical consultation helps colorectal cancer patients feel less anxious and more informed. About 100 adults scheduled for curative-intent colon or rectal surgery will be randomly assigned to either watch the video b…

This study tests whether using telemedicine and remote monitoring can help people with advanced digestive cancers manage chemotherapy side effects at home, reducing the need for emergency room visits and hospital stays. About 750 patients and their caregivers will receive enhance…

This study compares the effects of soy soft pretzels and wheat pretzels on inflammation in 30 men with obesity. Researchers want to see if the natural chemicals in soy can reduce chronic inflammation, which is linked to health problems like cancer. Participants will eat either so…

This study looks at 70 children aged 7 to 12 having appendix surgery. It compares two ultrasound-guided pain blocks to see which one reduces the need for extra pain medicine and improves recovery. The goal is to find a safer, more effective way to manage pain after surgery.

This study tests whether transanal irrigation (using water to flush the bowel) can improve quality of life and reduce bowel symptoms in 66 rectal cancer survivors who have low anterior resection syndrome (LARS). Participants learn the technique through an online platform with vir…

This study aimed to compare personalized nursing care (including counseling, temperature monitoring, and recovery guidance) with standard nursing for people having laparoscopic colorectal cancer surgery. The goal was to see if the personalized approach could reduce anxiety, preve…

This Phase 3 trial tests a drug called M701, given as an injection into the belly, to see if it can reduce the need for draining fluid in people with malignant ascites from advanced stomach, colorectal, or ovarian cancer. About 312 participants will either receive M701 plus drain…

This study tests whether a therapy program that combines in-person sessions with a smartphone app can help cancer patients feel more flexible in dealing with difficult thoughts and emotions. About 120 adults with breast, lung, or colorectal cancer will be randomly assigned to one…

This study tests a program that lets cancer patients receive care at home while undergoing chemotherapy or radiation. It includes remote monitoring and home visits to reduce the need for hospital stays or emergency room visits. The goal is to see if this approach improves quality…

This study tests whether online group counseling can help people who have a permanent colostomy due to colorectal cancer adjust better and improve their psychological well-being and resilience. About 48 adults will be randomly assigned to receive the counseling or not. The goal i…

This study tests whether a personalized care plan, based on a geriatric assessment, can reduce severe side effects in older adults (65+) starting chemotherapy for common cancers. Participants are randomly assigned to receive the assessment-driven plan plus usual care, or usual ca…

This study tests whether talking to an exercise specialist over the phone can help breast and colorectal cancer survivors become more active. Many people become less active after cancer treatment, and this program aims to change that. The trial includes 120 participants who recen…

This phase III trial is testing whether a telehealth self-management program can improve care coordination and quality of life for survivors of non-small cell lung cancer or colorectal cancer. About 403 participants who finished treatment 4 months ago will receive coaching sessio…

This study tests whether listening to jazz or reggae music can reduce chronic pain in people with IBS, Crohn's disease, or colitis. Researchers will compare two groups: one listens to mindful jazz, the other to reggae, over four weeks. The goal is to find a safe, non-addictive wa…

This study looks at whether adding a palliative care team early, before surgery, helps cancer patients manage symptoms like pain, fatigue, and anxiety. About 236 adults having certain abdominal cancer surgeries will either get usual care or usual care plus palliative support. The…

This study tests whether personalized exercise coaching can reduce fatigue and improve quality of life in children with inflammatory bowel disease (IBD). Seventy children will be split into two groups based on their current exercise habits and will follow a 24-week program with a…

This study looks at whether health education from nurses can improve quality of life and reduce anxiety and depression in people who have had digestive surgery and now have an ostomy. About 70 adults with permanent or long-term ostomies will take part in workshops and follow-up s…

This study follows over 64,000 adults who grew up on farms to see if early exposure to pesticides and other agricultural factors is linked to cancer. Participants fill out an online questionnaire and may provide biological samples. Researchers will track their health over many ye…

This study looks at whether taking extra random biopsies during a colonoscopy helps find precancerous growths in people with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. About 1,600 participants will be randomly assigned to one of two biopsy…

This study is testing whether regular screening for prostate, lung, colorectal, and ovarian cancers can reduce deaths from these diseases. About 154,900 men and women aged 55-74 were randomly assigned to either get screened or receive usual care. Researchers are tracking cancer c…

This study is creating a registry of 500 adults with functional GI disorders like IBS and chronic constipation. Researchers will collect medical data, diet and lifestyle questionnaires, and biological samples to explore genetic, microbial, and environmental factors. The goal is t…

This study is testing whether a ketone supplement called beta-hydroxybutyrate (BHB) is safe and tolerable for people scheduled for a colonoscopy or flexible sigmoidoscopy as part of their standard care. Participants will take a drink containing R-1,3-butanediol three times daily …

This pilot study tests whether daily, at-home stimulation of a nerve in the ear can change brain activity in people with inflammatory bowel disease (IBD) who are in remission. Fifteen adults with Crohn's disease or ulcerative colitis will use a small device for 28 days and underg…

This study follows 116 people with recurrent rectal cancer to understand how their treatment affects their quality of life and well-being. Participants fill out questionnaires every 3 months about their symptoms, daily activities, and overall health. The goal is to learn what mat…

This study tests whether a standard nutrition screening tool, called PYMS, can accurately identify children with Crohn's disease or ulcerative colitis who are at risk of malnutrition. Researchers will use the tool on 2,000 children aged 4–18 with IBD in outpatient and inpatient c…

This study tests two different drug combinations in people with advanced colorectal, pancreatic, or leiomyosarcoma cancers that have not responded to standard treatments. Participants receive either olaparib plus durvalumab or cediranib plus durvalumab. The main goal is to unders…

This study follows 565 people with stage I-III colon or rectal cancer to understand how treatment affects their finances and quality of life. Participants complete surveys about costs and financial well-being over 12 months. The goal is to help doctors better support patients fac…

This pilot study is testing whether regular MRI scans and blood tests can accurately track how rectal cancer responds to pre-surgery treatment. The goal is to develop a way to predict complete remission without needing surgery. Forty adults with locally advanced rectal cancer wil…

This study follows people with colorectal cancer that has spread to the lining of the abdomen (peritoneal metastasis) or with pseudomyxoma peritonei, a rare tumor of the abdominal cavity. Participants undergo cytoreductive surgery to remove all visible tumors, followed by intrape…

This phase II trial, called MATCH, is testing whether treating cancer based on the genetic makeup of a patient's tumor works better than standard treatments. Over 6,400 adults with advanced solid tumors, lymphomas, or multiple myeloma that have not responded to prior therapy are …

This trial is testing an investigational imaging device that uses shortwave infrared light to help surgeons see important structures like nerves, ureters, and bile ducts during surgery. The study involves adults aged 18 and older who are undergoing certain surgical procedures, su…

This study compares two strategies to increase colon and liver cancer screening among 30,300 veterans. One approach directly reaches out to veterans to schedule tests, while the other helps healthcare providers fix system issues. Researchers will track screening rates over 12 mon…

This study follows people treated for anal cancer with radiotherapy to see how their sexual quality of life changes over time. Participants complete questionnaires during treatment, three months later, and two years after diagnosis. The goal is to understand the long-term impact …

This study tested whether routine screening for four cancers (prostate, lung, colorectal, and ovarian) can lower the number of people who die from these diseases. Over 154,000 adults aged 55–74 joined the trial. Researchers compared cancer deaths between those who got screened an…

This study is testing whether a machine learning model can predict the extent of ulcerative colitis (UC) in the colon using only symptoms, physical signs, and lab results — before a colonoscopy is done. Researchers will analyze data from 1,500 people with UC to build and validate…

This study is testing whether a simple stool test can predict if the gut lining is healing in people with moderate-to-severe ulcerative colitis who are starting biologic therapy for the first time. Researchers will measure levels of a protein called calprotectin in stool samples …

This study is testing whether a blood test that looks for tumor DNA (ctDNA) can help doctors choose the right amount of chemotherapy for people with stage III colorectal cancer. About 2,450 participants will be split into groups based on their ctDNA results: those with negative c…

This research study looks at how certain cancers (head and neck, esophagus, and anal canal) change at the genetic and immune level when patients receive chemotherapy or immunotherapy. About 39 people with advanced cancer will provide blood samples and tumor tissue over time. The …

This study looks at tumor samples from over 3,000 people with advanced cancers to find specific biomarkers—unique features of each cancer. The goal is to help doctors choose the most promising targeted therapy or clinical trial for each patient. Participants are adults with vario…

This registry tracks adults with metastatic colorectal cancer who are starting their first systemic therapy. Researchers will collect information on the treatments doctors choose, how well they work, and patients' quality of life. The goal is to understand what happens in everyda…

This study tests a new device that takes detailed images of the lower gut during a standard colonoscopy. About 250 adults aged 45 to 75 will have the probe used during their procedure. The goal is to see if the device works well for real-time imaging.

This study looks at how chronic noncommunicable diseases like inflammatory bowel disease and breast cancer impact a person's ability to work. Researchers will follow 200 working-age adults for 12 months, collecting data on health, work performance, and well-being. The goal is to …

This study looks at how common muscle loss (sarcopenia) is in people with gastrointestinal cancer. Researchers will use a short questionnaire to screen patients before and during treatment. Those flagged as at risk will get extra nutritional support. The goal is to see if early d…

This study uses an online survey to learn what gay and bisexual men in the U.S. know about anal cancer risk and prevention. Participants answer questions about their awareness of screening options and their experiences with care. The goal is to identify gaps in knowledge and acce…

This study looks at whether a fermented wheat germ supplement can help the immune system fight cancer better when taken with standard immunotherapy drugs. About 100 adults with advanced solid tumors (like lung, colon, or melanoma) will take the supplement alongside their usual tr…

This study aims to identify which of four French-validated questionnaires is most suitable for assessing sexual function in women who have had surgery for rectal or recto-sigmoid cancer. Researchers will ask 50 women to complete all four questionnaires and rank their preferences.…

This study tests whether offering a blood test (cell free DNA) alongside standard stool tests and colonoscopy increases colorectal cancer screening rates among people who are not up-to-date with screening. The trial enrolls 340 adults aged 45-75 at a health center serving low-inc…

This study looks at whether two blood markers, zonulin and LBP, can help detect liver damage in people with both ulcerative colitis (UC) and fatty liver disease. Researchers will measure these markers and use a special ultrasound to check liver stiffness in 100 adults with UC who…

This long-running study follows nearly 100,000 French women, mostly teachers, since 1990 to understand what factors influence their risk of cancer, heart disease, diabetes, and other major illnesses. Participants fill out questionnaires every few years about their lifestyle, medi…

This study tests new ways to help rural primary care clinics provide better follow-up care for cancer survivors. Researchers will give clinics telementoring, quality improvement coaching, and an obesity management toolkit. The goal is to see if these tools help clinics follow nat…

This study was designed to see how accurately patients report their own medication and healthcare use in diaries compared to official health insurance records. It planned to include people with diabetes, arthritis, kidney disease, or prostate cancer. However, the study was withdr…

This study looks at how diet, genetics, and gut bacteria work together to cause digestive problems like IBS, IBD, and celiac disease. Researchers will follow about 4,000 adults with and without these conditions to find patterns. The goal is to understand why some people get sick …

This study looks at whether a special home care program helps people with a new stoma (a surgical opening on the belly) recover better after colorectal cancer surgery. About 98 adults who had a stoma created will get extra support and teaching to manage their stoma at home. The g…

This study planned to look back at MRI scans of people with rectal cancer to see if the images could predict how aggressive the cancer is and how well it responds to treatment. The goal was to create a computer model to help doctors make better decisions. However, the study was w…

This study aimed to see if a blood test for cancer DNA (ctDNA) could help doctors decide which patients with stage 2 or 3 rectal cancer could safely avoid surgery and just be watched closely. It also looked at using the test to catch any cancer coming back early. However, the tri…

This study looks at whether having close contact with pets can help keep your gut healthy while taking antibiotics and lower the risk of a serious infection called C. difficile. Researchers will follow 200 adults getting dental implants who need antibiotics, checking their gut ba…

This study looks at how frailty—a state of weakness and reduced physical function—affects the risk of severe side effects from chemotherapy in people aged 70 and older with cancer. Researchers will assess 160 patients using various tests for frailty, muscle loss, and overall heal…

This study examines if the amount of a bacteria called Fusobacterium nucleatum in colon cancer tumors is linked to how well patients respond to targeted therapies like cetuximab or panitumumab. Researchers will analyze stored tumor samples from 500 patients with metastatic colore…

This study looks at how the drug infliximab behaves in the body of people hospitalized with severe ulcerative colitis. Researchers measure drug levels in blood, stool, and colon tissue, along with changes in proteins and genes. The goal is to better understand how the drug works,…

This study looks at whether telling people over 45 their genetic risk for colorectal cancer helps them decide to get their first colonoscopy. Researchers will track how many people schedule a colonoscopy after learning their risk, and compare findings like polyps between risk gro…

This study tests a new way of organizing care for people aged 70 and older who have cancer (breast, lung, colorectal, or prostate) plus at least one other serious health condition. The GERONTE program brings all their doctors and nurses together using a shared digital care plan. …

This study screens adults interested in fecal microbiota transplant (FMT) for Clostridium difficile infection. Researchers will collect medical information and run basic health tests to create a database of potential participants. The goal is to make it faster and easier to enrol…

This study tests whether AI-generated messages can change how cancer survivors think about alcohol and cancer risk. About 850 adults who have had certain cancers and currently drink alcohol will view different messages. Researchers will measure changes in their beliefs about canc…

This study is a long-term follow-up for 400 people who previously received A2 Bio gene therapy for various solid tumors, including colorectal, lung, pancreatic, and ovarian cancers. No new treatment is given; instead, researchers will track participants over time to check for del…

This study tests a special camera that measures oxygen levels in the bowel during colorectal surgery. Surgeons will use it to see if low oxygen areas predict leaks after the procedure. About 52 adults having laparoscopic colorectal surgery will take part. The goal is to see if th…

This research study collects tissue, blood, and other samples from 2,400 people diagnosed with breast, colon, kidney, liver, multiple myeloma, or prostate cancer at a young age. The goal is to identify genetic changes that may explain why these cancers occur early, especially in …

This study looks at survival rates for people with cancers like melanoma, breast, colon, and lung cancer using data from Russian cancer registries. It includes 100,000 people of any age. The goal is to understand survival trends to help improve cancer care, not to test a new trea…

This study reviews medical records from 300 cancer patients to see if the makeup of a tumor's surroundings (the tumor microenvironment) is linked to how well antibody-based therapies work. Researchers will analyze tissue samples and blood markers from patients with seven types of…

This study compares open D3 surgery with laparoscopic CME surgery for right-sided colon cancer in 128 patients. The goal is to see if laparoscopic surgery leads to less pain, fewer complications, and faster recovery, while still being as effective at removing cancer. Researchers …

This study analyzes data from over 45,000 people diagnosed with colon or ovarian cancer in England between 2016 and 2017. Researchers are looking for differences in how quickly people are diagnosed and what treatments they receive, based on their socioeconomic status. The goal is…

This study follows 72 women with pelvic cancers (anal, cervical, endometrial, rectal, vaginal, or vulvar) who are receiving radiation therapy. Researchers will use pelvic exams and surveys to measure changes in vaginal health, sexual function, and quality of life over two years. …

This study looks back at the experiences of 37 people with colorectal cancer treated at a single hospital. Researchers are tracking how long patients survive after diagnosis. No new treatments are being tested; the goal is to learn from real-world outcomes.

This study looks at whether changes in tumor DNA found in the blood (ctDNA) can predict if chemotherapy is working in people with advanced colorectal cancer that no longer responds to standard treatments. About 103 participants will give blood samples and have regular scans to tr…

This study looks at whether a simple blood test can find tiny bits of cancer DNA left in the body after surgery for colorectal cancer. The goal is to identify patients at high risk of the cancer coming back, so doctors can adjust follow-up care. Over 3,000 people with stage I-III…

This study tests a computer tool that uses maps and location data to help infection preventionists find and stop hospital-acquired infections faster. About 25 infection prevention staff will use the tool and report how easy it is to use and whether it helps them respond more quic…

This study looks at 64 patients with colorectal cancer that spread to the liver and was surgically removed. Researchers are analyzing tumor samples to see how different immune cells and growth patterns relate to survival and cancer recurrence. The goal is to better understand why…

This study tests whether a two-week plant-based Mediterranean diet can change gut bacteria and reduce inflammation in people who have had colon polyps removed. Thirty participants will eat high-fiber meals delivered to their homes, and researchers will track changes in blood and …

This study is for people with gastrointestinal cancer that has spread to the lining of the abdomen. Researchers will collect tumor tissue and blood samples to create a custom blood test that looks for cancer DNA. The goal is to see if this test can help doctors monitor the cancer…

This study looks at 50 patients with peritonitis caused by a burst diverticulum in the colon. Researchers will measure 92 inflammatory proteins in abdominal fluid and blood, and analyze tissue and bacteria changes. The goal is to better understand why some people develop this lif…

This study looks at how well a stoma works and how it affects quality of life in people with colorectal cancer. Researchers will compare those who had a stoma created as an emergency procedure with those who had it planned ahead of time. About 700 participants will answer a quest…

This study looks at whether a blood test that detects tumor DNA can accurately identify patients who still have cancer after local removal of early-stage colorectal cancer. Currently, many patients undergo additional surgery even though about 85% are already cured by the initial …

This study enrolls 4,000 people with breast, ovarian, or colorectal cancer to test a comprehensive genetic panel. The panel looks for inherited cancer risks and tumor mutations that may affect drug sensitivity. Researchers aim to validate these genetic findings to potentially gui…

This study tests whether a simple blood test that looks for tumor DNA can detect colorectal cancer coming back earlier than standard CT scans. About 359 people who had surgery for stage II or III colorectal cancer will be randomly assigned to either the blood test plus frequent P…

This study looks at genetic and molecular markers in tissue and stool samples from people with colon cancer, colon polyps, and healthy controls. Researchers aim to understand how these markers differ and how they relate to cancer development. The study involves 582 participants a…

This study looks at how small changes in CT scan settings affect measurements of colorectal cancer tumors that have spread to the liver. About 169 adults with these tumors will get an extra CT scan. The goal is to see if tumor measurements stay reliable even when scan details var…

This study compares two surgical methods for emergency colon removal: laparoscopic (keyhole) and open surgery. Researchers want to see which approach leads to fewer complications and better long-term survival. The trial involves 192 adults who need emergency colon surgery, exclud…

This study is testing a special thermal probe that measures temperature changes in the lining of the colon during a routine colonoscopy. The goal is to see if the probe can detect inflammation in people with inflammatory bowel disease (IBD), including Crohn's disease and ulcerati…

This study was designed to test whether a special fluorescent dye and advanced cameras could help surgeons see colorectal cancer cells more clearly during operations. The goal was to remove all cancer cells and reduce the chance of the cancer coming back. However, the study was w…

This study looks at whether a quick, 8-item screening tool called G8 can help predict survival and severe side effects from treatment in elderly patients (70 years and older) with metastatic colorectal cancer. The goal is to find a simple way to identify which older patients are …

This study looks at how a person's genes and medical history might help predict nerve damage caused by chemotherapy. Researchers will follow 300 people with certain cancers who are scheduled for specific chemo drugs. The goal is to find patterns that could help prevent or reduce …

This study looks at how to improve colorectal cancer screening in rural clinics in Indiana. Clinics will mail FIT kits, send reminders, and use patient navigators to help people aged 45-75 get screened. The goal is to see which strategies work best to increase screening rates and…

This study analyzes tumor genes from 757 patients with advanced colorectal cancer to find markers that predict how well they respond to two different chemotherapy combinations. Participants receive either mFOLFOX6 plus bevacizumab or mFOLFOX6 plus panitumumab. The goal is not to …

This study examines DNA from over 21,000 cancer patients in New York to find gene changes linked to several cancers, including breast, colon, and lung. Researchers will compare these genes to those from healthy people to spot differences. The goal is to generate ideas for future …

This study involves 320 adults with advanced rectal cancer who received standard chemoradiotherapy and surgery. Researchers are building a computer model that uses MRI scans and patient data to predict whether the cancer has completely disappeared after treatment. The goal is to …

This study looks at whether helping people aged 40-49 with a family history of colon cancer make informed choices about screening leads to more colonoscopies. Participants either get standard care (direct referral for colonoscopy) or a shared decision-making session where they ca…

This study looks at whether a detailed blood test can help doctors see how well treatment is working and predict if cancer will come back in people with colorectal cancer that has spread to the liver or lungs (up to 5 spots). The test checks for tumor DNA, RNA, proteins, and othe…

This study looks at 400 adults with acute appendicitis to figure out who can be treated with antibiotics alone and who needs surgery. Researchers will track lab results, imaging, and symptoms to see which approach works best for each patient. The goal is to help doctors choose th…

This pilot study is looking at whether dental erosion (loss of tooth enamel) could be a non-invasive biomarker for esophagogastric cancer and other cancers. Researchers will survey 174 participants (cancer patients and healthy volunteers) about diet, habits, and GERD symptoms, an…

This study collects tumor tissue, blood, and saliva from 2500 people with various solid cancers to analyze their genetic makeup. The goal is to understand why some tumors become resistant to targeted therapies. Samples may also be grown in special mice to study how genetics affec…

This study aimed to see if two advanced imaging modes, TXI and RDI, built into standard colonoscopy equipment, could make removing large colon polyps faster and safer. The trial was planned for adults with polyps 20 mm or larger, but it was withdrawn before any participants were …

This study looks at whether continuous heart rate variability (HRV) monitoring can predict how well patients with inflammatory bowel disease (IBD) respond to biologic therapies like infliximab or vedolizumab. Researchers will track HRV in 100 patients starting treatment and compa…

This study looks at people aged 45-74 who had a positive fecal immunochemical test (FIT) but a normal colonoscopy. Even with a clear colonoscopy, these individuals may still have a higher risk of colorectal cancer. The trial will compare two follow-up options after two years: ano…

This study is a national registry collecting data from 1500 people with familial adenomatous polyposis (FAP) and related conditions across 28 Italian centers. It aims to better understand how these diseases progress, how they are currently managed, and what factors influence outc…

This study planned to test if a 7-week program of aerobic and resistance exercise is feasible for people with locally advanced rectal cancer undergoing short-course radiotherapy. It aimed to recruit 30 patients and track how many joined, attended sessions, and stayed in the study…

This observational study looks back at 700 patients from 15 hospitals in 2 countries to compare local treatments like surgery and radiation for brain metastases that spread from colorectal cancer. Researchers will track how long patients live and how long it takes for brain tumor…

This study aims to understand how inflammatory bowel disease (IBD) affects patients' quality of life. Researchers will survey 385 adults with Crohn's disease or ulcerative colitis about their symptoms, emotional well-being, and social support. The goal is to identify factors that…

This study aimed to see if giving patients a simple pamphlet with a social norm message (showing how their clinic's screening rate compares to others) could increase the number of people completing a take-home colorectal cancer screening test (FIT). The plan was to enroll adults …

This study tests a new payment model for cancer care in Hawaii. Instead of paying for each service separately, doctors get a single payment for an episode of care, with bonuses for meeting quality goals. The study includes 7 oncologists and looks at how this affects care quality,…

This study follows 189 adults hospitalized with acute severe ulcerative colitis to track their treatments and outcomes. Researchers will collect detailed medical data to identify factors that predict whether a patient needs stronger medications or emergency surgery. The goal is t…

This study is collecting blood, stool, and urine samples from 1,000 people with Inflammatory Bowel Disease (IBD). Researchers will store these samples along with medical information to learn more about the disease and find ways to improve patient outcomes. The study does not invo…

This study tests a digital toolkit called eNav, which includes a website and text message reminders, to help people aged 45–75 get screened for colorectal cancer. The toolkit provides information, motivation, and easy ways to request a screening test. Researchers will compare scr…

This study looks at whether watching an online genetics video, with or without phone counseling from a genetic counselor, can reduce the stress women feel about their cancer risk. It involves 5,200 women aged 30 or older who have had triple-negative breast cancer and still have a…

This study aimed to create a web-based decision aid for people invited to cancer screening in Sweden. The tool would provide clear information about the benefits and harms of screening, helping individuals decide based on knowledge rather than fear. The study was withdrawn before…

This study looks at how bacteria living in the gut and diet might influence colorectal cancer risk in people with Lynch syndrome and other inherited colon conditions. Researchers will collect stool samples, colon biopsies, and diet questionnaires from 77 participants during routi…

This trial tests a dye mixture called Luminomark, which is injected into the colon wall near a tumor during a colonoscopy. The dye glows under a special camera during surgery, helping surgeons see exactly where to cut. The study involves 30 adults with early-stage colorectal canc…

This study follows over 96,000 Seventh-day Adventists in the U.S. and Canada to see how diet and lifestyle choices relate to breast, colorectal, and prostate cancer. Researchers are focusing on intakes of meat, soy, and dairy. Because it is observational, it can show patterns but…

This observational study is following up to 500,000 adults with chronic gastrointestinal diseases like Crohn's disease, ulcerative colitis, and eosinophilic GI disease. Researchers will collect data from electronic health records and patient reports to understand how these condit…

This study looks back at 193 people with stomach, appendix, or colon cancer who had surgery with or without heated chemotherapy (HIPEC). Researchers want to see if HIPEC affects how quickly the bowels start working again after surgery and whether it leads to more complications. T…

This long-running study at Johns Hopkins aims to identify the genetic and environmental factors that cause inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. Researchers are enrolling 2,500 participants — including patients, their family members, …

This study aimed to find out if certain genes that affect bleeding can cause a false positive result on a stool test used to screen for colon cancer. Researchers planned to compare genetic markers in people who had a high test result but a normal colonoscopy with those who had no…

This study looks at 266 adults with advanced rectal cancer who had radiation therapy followed by surgery. It compares standard chemoradiotherapy or short-course radiotherapy with a newer approach called total neoadjuvant treatment (TNT). The goal is to see which method leads to f…

This study aims to better understand inflammatory bowel disease (IBD) by collecting tissue samples from 1,100 people undergoing endoscopy or bowel surgery. Researchers will analyze gene activity, proteins, and gut microbes to learn what causes the disease. The study includes both…

This study is testing a blood test that looks for tiny bits of cancer DNA in the blood after colorectal cancer surgery. The goal is to see if this test can predict whether the cancer will return. Over 1,000 people with stage II or III colorectal cancer will be followed for up to …

This study collects blood and saliva samples from people with cancer and their relatives to build a DNA bank. Researchers hope to better understand how cancer runs in families. About 992 participants are expected to join. The samples will be stored and analyzed later for genetic …

This study tests a program called Potlako+ that combines community education, support for healthcare providers, and patient navigation to help people with cancer symptoms get diagnosed and treated faster. About 874 participants in Botswana will be split into two groups: one recei…

This study aimed to see if changing how cancer patients think about their illness could improve their quality of life and treatment outcomes. Researchers planned to follow newly diagnosed patients and give some a short mindset training. However, the study was withdrawn before any…