New drug cocktail before radiation shows promise against rectal cancer

NCT ID NCT04503694

First seen Mar 30, 2026 · Last updated May 12, 2026 · Updated 6 times

Summary

This study tests whether giving two drugs (nivolumab and regorafenib) before and after a short course of radiation can shrink tumors in people with stage II or III rectal cancer. About 72 participants will receive the treatment, then either have surgery or be closely watched if the cancer disappears. The goal is to see how many patients have no cancer left after treatment.

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Contacts and locations

Locations

  • AZ Groeninge

    Kortrijk, 8500, Belgium

  • CHR Namur

    Namur, 5000, Belgium

  • CHU Ambroise Paré

    Mons, 7000, Belgium

  • Chirec Delta

    Brussels, 1160, Belgium

  • Cliniques Universitaires Saint-Luc

    Brussels, 1200, Belgium

  • Grand Hopital de Charleroi

    Gilly, 6060, Belgium

  • Institut Jules Bordet

    Anderlecht, 1070, Belgium

  • UZ Gent

    Ghent, 9000, Belgium

  • UZAntwerpen

    Edegem, 2650, Belgium

Conditions

Explore the condition pages connected to this study.